CN108938508A - A kind of fig fruit extract and application thereof with sun-proof synergistic effect - Google Patents

Abstract

The present invention relates to a kind of fig fruit extracts and application thereof.The fig fruit extract makes an addition to the sun-proof building capability in sunscreen product with wide spectrum as natural plant raw material, can suitably reduce physical, chemically sun-screening agent dosage.The sunscreen product stability, safety are preferable, possess good concealing and highlight effect, and skin sense, smell are good, and irritation risk reduces, and have a vast market application prospect.

Description

A kind of fig fruit extract with sunscreen synergistic effect and application thereof

technical field

The invention relates to the technical field of cosmetics, in particular to a fig fruit extract with sunscreen synergistic effect and its application.

Background technique

Because the current sunscreen products on the market are dominated by physical and chemical sunscreens, their usage has many impacts on skin feel and safety. With people's pursuit of green safety concepts, it is a general trend to apply natural plant materials to sunscreen products. Plant-derived sunscreen ingredients mainly include alkaloids, fatty acids, steroids, polyphenols, polysaccharides, and polypeptides. When used alone, the sun protection factor (SPF) is low, so the ideal sunscreen effect cannot be achieved.

As a medicinal and edible fig, it is known as the "Guardian of Human Health in the 21st Century" because it is rich in fiber, polyphenols, vitamins, organic acids and other nutritional elements. Its research status is mainly aimed at fig leaves, focusing on the evaluation of antibacterial, anticancer, cytotoxicity and other medical fields. In cosmetics, it focuses on adding it to products as a fragrance modifier.

Paper Khan, H., Akhtar, N., & Ali, A. (2014). Effects of Cream Containing Ficuscarica L. Fruit Extract on Skin Parameters: In vivo Evaluation. Indian Journal Of Pharmaceutical Sciences, 76(6), 560-564. The effects of emulsions formulated with fig fruit extract on human skin parameters including skin melanin, erythema, epidermal hydration and sebum production were studied. The basic formula containing 4% fig fruit extract was used as a test reagent, and the basic formula was used as a control, which was applied to the cheek skin of random volunteers for 8 weeks. The test results show that the water-in-oil emulsion containing fig fruit extract in the formula can effectively reduce skin melanin content, reduce epidermal water loss, reduce oil secretion, and enhance skin hydration. It is not difficult to see from this that the few fig extracts used in the prior art of cosmetics have only studied their moisturizing and whitening effects; and no attention has been paid to the application of fig fruit extracts in cosmetics and its effect on sunscreens. Synergy, that is, its use in sun care products.

The patent application number 201711499544.7 discloses a new type of sunscreen synergistic composition. The composition includes comfrey extract, ginger root extract, bisabolol and polygallocatechin gallate acid, which has no sunscreen effect by itself, but can be added to conventional sunscreen agents to greatly increase the sunscreen index. This invention mainly screens the ingredients with synergistic effects in the composition and the optimal addition amount of the corresponding ingredients, and discusses the sunscreen synergistic effect of the composition in different substrates, but does not study the effect of fig fruit extract on different sunscreen agents. Synergistic effect of the formulation.

Therefore, in view of the above situation, applying fig fruit extract to sunscreen products to explore its synergistic effect on different sunscreen formulations will help reduce the amount of sunscreen added in cosmetic formulations, reduce the irritation of cosmetics to the skin, and achieve green safety. The concept of sun protection is very important.

The present invention is proposed under the above technical background. It is obviously different from the prior art. The present invention uses figs and fig fruit extracts for the preparation of sunscreen products, and unexpectedly finds that it has obvious synergistic effect on different types of sunscreen agents.

Contents of the invention

Aiming at market demands and deficiencies in the prior art, the present invention aims to add figs and fig fruit extract gradients to physical, chemical and physicochemical compound sunscreen formulations to develop their sunscreen synergistic effect.

The invention provides the use of fig in the preparation of sunscreen products.

Further, the present invention implements the use of different parts of fig in the preparation of sunscreen products.

Hereinafter, the technical solution of the present invention will be described by taking fig fruit as a representative, but it does not mean that other parts of fig fruit cannot reach the same or similar effects achieved by fig fruit. That is, extracts from other parts of the fig plant can achieve the same or similar effects as the fig fruit extract set forth below.

As a set of specific and exemplary embodiments, the present invention provides a use of fig fruit extract in the preparation of sunscreen products.

In the implementation process of the present invention, the following methods are used, including but not limited to: fig fruit extracts extracted according to published papers, patents, etc., which are legally known to the public; extracts; fig fruit extract obtained through legitimate commercial purchases.

The above various ways to obtain fig fruit extracts can achieve the same or similar technical effects in this group of embodiments.

The following takes the fig fruit extract obtained through commercial purchase as an example to illustrate the embodiment of this group.

The fig fruit extract obtained through the commercial purchase channel was purchased from Shaanxi Xi'an Health Raw Material Square, the product number is F6008, and the batch number is 201803001A.

During the implementation of the present invention, the above-mentioned commercially purchased fig fruit extracts were measured, including fig fruit total flavonoids, fig fruit total polysaccharides and fig fruit total polyphenols, and the contents of the three were 0.0064mg/mL and 1.46mg/mL respectively. mL and 0.0047mg/mL.

The fig fruit extract with the above content can achieve a certain technical effect for a certain technical problem in this group of embodiments; the fig fruit extract with other component contents can also obtain corresponding technical effects in other technical problems.

During the implementation of this group of embodiments, the fig fruit extract is used together with a sunscreen agent to prepare the above sunscreen product.

That is, the sunscreen product includes sunscreen and fig fruit extract.

The sunscreen is a physical sunscreen, a chemical sunscreen or a physicochemical compound sunscreen.

The physical sunscreens include but are not limited to titanium dioxide.

The chemical sunscreens include, but are not limited to, ethylhexyl methoxycinnamate.

The physical and chemical compound sunscreen is a mixture of physical sunscreen and chemical sunscreen;

The physicochemical compound sunscreen includes but not limited to ethylhexyl methoxycinnamate and titanium dioxide.

In some specific embodiments, the physical sunscreen includes titanium dioxide.

In other specific embodiments, said chemical sunscreen comprises ethylhexyl methoxycinnamate.

In still some specific embodiments, the physicochemical compound sunscreen is ethylhexyl methoxycinnamate and titanium dioxide.

In some more specific embodiments, the physical sunscreen agent is titanium dioxide, which accounts for 4%-25% by weight in sunscreen products, and the proportion of fig fruit extract in sunscreen products The weight percentage is 0.01%-1.13%.

In other more specific embodiments, the chemical sunscreen is ethylhexyl methoxycinnamate, and its weight percentage in sunscreen products is 4%-10%, and the fig fruit The weight percentage of the extract in the sunscreen product is 0.01%-1.11%.

In some more specific embodiments, the physicochemical compound sunscreen is ethylhexyl methoxycinnamate and titanium dioxide, and the weight percentage of titanium dioxide in the sunscreen product is 5%-25% %, the weight percentage of ethylhexyl methoxycinnamate in sunscreen products is 5%-10%, and the weight percentage of fig fruit extract in sunscreen products is 0.01%- 1.07%.

The sunscreen product may also include any additives conventionally used in the art.

Compared with prior art, the beneficial effect that the present invention obtains is:

(1) During the implementation of the present invention, it was unexpectedly found that mixing fig fruit extract and sunscreen agent in sunscreen products and controlling the weight percentage of fig fruit extract and sunscreen agent can effectively increase the sunscreen effect of sunscreen products.

(2) The use of fig fruit extract as a natural plant material in sunscreen products has antibacterial, antioxidative, antiaging, and whitening potentials, that is, it has the intuitive effect of concealing blemishes and does not need to add flavors, and can appropriately reduce physical and chemical sunscreens The dose can reduce the risk of cosmetic irritation caused by the increase in the use of sunscreen to a certain extent, and has broad market application prospects.

Detailed ways

The fig fruit extract (hereinafter referred to as fruit extract A) used in this paper is purchased from Shaanxi Xi'an Healthy Raw Materials Square (this extract is 10 kilograms of raw materials to extract 1 kilogram of products, without additives such as preservatives, soluble in water, and its fig fruit source is Polyflowers of the Moraceae fig). The instruments and reagents used in the present invention are shown in Table 1.

Table 1 Test equipment and reagents

1. Extract Solubility Test

1.1 Fat solubility test

Weigh 1.00g of fruit extract A into 10mL of absolute ethanol, stir evenly, a large amount of precipitation appears, and after standing for a while, the layers are separated.

1.2 Water solubility test

Weigh 1.00g of fruit extract A into 10mL of deionized water, add every 10mL of deionized water gradient, heat and stir at 70°C for 10min, and ultrasonicate for 5min (ultrasonic conditions are 28°C, 70% power), when the total amount of deionized water is added to When 60mL, it presents a clear, translucent, brown-yellow homogeneous solution with a special smell, and there are a small amount of small particles at the bottom of the standing beaker. When the fruit extract A was added to 6 g per 1 g of the glycerol compound solution in a gradient, the small particles at the bottom of the cup were almost completely dissolved.

In summary, it can be seen that 1.00 g of fruit extract A in the present invention can be completely dissolved in 60 mL of deionized water and 6 g of glycerin compound solution.

2. Preparation of Sunscreen Products

In order to exclude the possible interference of fig fruit extract itself with sunscreen ability, the highest concentration of fruit extract A was added to the formula without any sunscreen ingredients, which was set as a blank group. Table 2 is the components of the blank group.

Table 2 Blank group components

Sunscreen products were prepared by mixing different contents of fig fruit extracts with different components of sunscreens, and the following three groups of examples were obtained.

Example group 1

Table 3 Effects on Titanium Dioxide

Example group 2

Table 4 Effects on Ethylhexyl Methoxycinnamate

Example group 3

Table 5 Effects of Physicochemical Sunscreen Complex (Ethylhexyl Methoxycinnamate + Titanium Dioxide)

Comparative example group 1

Table 6 Effects on Benzophenone-3

Comparative example 2

Mentholatum New Clear Water Thin Sunscreen Lotion (SPF=25).

2.1 Preparation process

Above-mentioned blank group, embodiment group 1-3 and comparative example group 1 are prepared with following process:

(1) Weigh phase A and phase B respectively according to the formula and dosage, and heat to 85°C respectively;

(2) Pour phase A into phase B, homogenize at 5600r/min for 5min, add polysorbate-60, homogenize for 1min, cool to 40°C, add phenoxyethanol, 1,2 hexanediol, 300r/min Stir and cool down to 28°C, dispense into 10mL centrifuge tubes, and obtain sunscreen products.

2.2 SPF value test

At present, the domestic and foreign methods for testing the SPF index of sunscreen products include human body test method and in vitro instrument test method, both of which are restricted by different factors. However, the human body test method has disadvantages such as time-consuming, troublesome operation, high cost, large individual differences, and difficult selection of test groups. Compared with this, the in vitro instrumental test method is slightly better. Yan Shuxian and others verified the correlation between the SPF index of sunscreen cosmetics in vitro instrument test method and human test method. The results showed that the two had a good correlation (r=0.9616), and the SPF values measured by the two methods had no significant difference (0.40<P<0.50). Therefore, this test will use the in vitro instrument test method to evaluate the SPF index of the above samples. The SPF analyzer can automatically calculate the SPF value, Boots Star, MPF value and absorbance, and will fully display the UVA/UVB test value, which can be printed Test reports and graphs. The test environment is a constant temperature and humidity room, the temperature is controlled at (20±2)°C, and the relative humidity is (50±5)%.

2.2.1 Inspection of coating carrier

Before the formal measurement, according to the measurement steps, three groups of parallel tests were carried out on a sample using medical tape and polymethyl methacrylate (PMMA) plate to investigate the stability of the two carriers. The results show that the values measured using PMMA boards have smaller deviation than tape method, so the carrier used in the following experiments is PMMA boards.

2.2.2 Test steps

Coating samples: Take ² mg/cm of each sample in Example Group 1-3 and Comparative Example Group 1 with a special sampler on the PMMA plate, put on medical finger cots and smear evenly, no visible samples on the finger cots before and after smearing, All samples were coated by the same method, and each sample was subjected to 3 parallel tests. Place the smeared sample plate in a dark environment to form a film naturally for 20 minutes, to be tested.

Calibrate the instrument: Before the test, use the calibration filter that comes with the instrument to scan the 6 points on the edge and center of the PMMA empty plate under a 125W continuous xenon lamp light source for calibration to ensure the accuracy of the test.

Test samples: In the same way as calibrating the instrument, test each sample with the SPF-290s sun protection index analyzer. The instrument draws 6 light wavelengths MPF (Monochromatic Protection Factor, monochromatic light protection index) for each sample, and the relevant indicators of the sample are calculated by the supporting software of the instrument.

In order to minimize the measurement error, the samples obtained from the formula gradient test were placed in a dark environment at room temperature for 48 hours to ensure the stability of the paste or solution, and Table 7 was obtained.

Table 7 measured SPF value

Note: Through testing, the SPF value of the blank group is 0.67.

A0, B0 and C0 in the example group are compared with other examples in the corresponding example group. According to the measured SPF value of the blank group and Table 7, the following conclusions can be obtained:

(1) Fig fruit extract itself has no sunscreen effect;

(2) The sunscreen synergistic object of fig fruit extract is selective, and its synergistic effect is the best when the weight percentage of fig fruit extract and sunscreen agent in sunscreen products is within a certain range. The extract has a linear effect of sunscreen synergy to titanium dioxide or ethylhexyl methoxycinnamate, but has no linear effect of sunscreen synergy to benzophenone-3;

(3) Fig fruit extract has a linear synergistic effect on the linearly synergistic sunscreen combination (ethylhexyl methoxycinnamate + titanium dioxide), and its synergistic effect is greater than that of fig fruit extract and sunscreen agents in sunscreen products The effect is optimal when the weight percentage in a certain range.

3 Stability evaluation of sunscreen products

The present invention investigates the stability of the sunscreen products in Example Groups 1-3, Comparative Example Group 1 and Comparative Example 2. The samples obtained in Example Group 1-3, Comparative Example Group 1 and Comparative Example 2 were placed in normal temperature, normal temperature dark environment, light, thermal environment (45 ± 1 ° C air-tight air-tight oven), refrigerated at 4 ° C, frozen Under the seven conditions of environment (-15±1°C), alternating cold and heat (-15±1°C and 45±1°C for 24 hours), observe the characteristic changes after a period of time, and the results are shown in Table 8 and Table 9.

Table 8 28-day stability observation results of sunscreen products

Table 9 78-day stability observation results of sunscreen products

Note: "-" means there is no change compared with the initial state; "1" means there is a little floc; "2" means that the sweetness in the special smell is slightly weakened; "3" means that the color of the bottom is slightly darker than that of the upper layer; 1 and 3 Shake well to restore the original state.

The stability observation results of fig sunscreen products show that when fig extract is used in sunscreen products, the sunscreen products have good stability and no changes in floc, odor, color, etc. Similarly, the stability of Comparative Example 2 is also better. However, the stability of the sunscreen products in Comparative Example 1 was relatively poor, and problems such as a little flocs, slightly weakened sweetness in the special smell, or slightly darker bottom color than the upper layer appeared on 28 days and 78 days.

4 Safety evaluation of fig fruit extract

The safety of fig fruit extract was tested by erythrocyte hemolysis and coagulation test.

Red blood cell test (RBC) is one of the alternatives to the Draize test. It evaluates the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin exudation and deformation. The RBC test is mainly used in cosmetic products internationally. Eye irritation studies of chemicals such as raw materials and raw materials.

The reagent used in the invention is a compound solution of fig fruit extract, and the method used is a standard erythrocyte hemolysis and coagulation test method. As can be seen from Table 10, the extract solution is non-irritating and has good safety.

Table 10 fig fruit extract compound solution erythrocyte hemolysis test (RBC) result

5 Efficacy evaluation of sunscreen products

5.1 Test reagents

Randomly select A1, B4, C3, A0, B0 and C0 groups in the embodiment group 1-3, D1 group and the product of the comparative example 2 in the comparative example group 1.

5.2 Test method

Find 18 volunteers who meet the requirements for trial, take a blind test (anonymous), apply the product sample on the human skin (such as the inner arm, back of the hand, etc.), the overall feeling of the product, the specific absorption effect, and spread Corresponding evaluations were given on subjective aspects such as sex, moisturizing effect, fineness, gloss, viscosity, concealer, and freshness. The evaluation of each item adopts a scoring system: very good 9-10 points; good 7-8 points; general 5-6 points; poor 3-4 points; very poor 1-2 points.

5.3 Test data

The human test integrated people with different skin types, and their sensory evaluations are shown in Table 11:

Table 11 Product sensory evaluation table

Note: The sensory evaluation data in the table is the average value of the evaluation scores of 18 volunteers.

5.4 Test conclusion

The test shows that after adding fig fruit extract, the fineness and concealment scores of the cosmetics are all above 9 points, and the satisfaction is good; the spreadability and freshness are both 7-8 points, which is relatively satisfactory; the absorption effect, moisturizing effect, The glossiness and viscosity are both 8-10 points, and the selected people feel good about the target product overall, which is better than sunscreen products without fig fruit extract. Although Mentholatum's new clear water thin sunscreen lotion has a relatively high SPF value and good stability, its product efficacy is relatively weaker than that of the present invention.

To sum up, the sunscreen product of the present invention has passed the stability and safety tests and meets the requirements for cosmetics to be marketed, and the sunscreen product has a good concealing and brightening effect, good skin feel and smell, and has broad application prospects.

The above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention, simple modifications or equivalent replacements to the technical solution of the present invention by those of ordinary skill in the art will not depart from the essence of the technical solution of the present invention and range.

Claims (10)

1. Use of figs in the preparation of sunscreen products. 2. The use according to claim 1, characterized in that: the use of the fig fruit extract in the preparation of sunscreen products. 3. The use according to claim 2, characterized in that: the fig fruit extract comprises fig fruit total flavonoids, fig fruit total polysaccharides and fig fruit total polyphenols. 4. The use according to claim 2, characterized in that: the fig fruit extract and sunscreen are jointly used to prepare sunscreen products. 5. The use according to claim 4, characterized in that: the sunscreen is a physical sunscreen, a chemical sunscreen or a physicochemical compound sunscreen. 6. The use according to claim 5, characterized in that: the physical sunscreen is titanium dioxide. 7. The use according to claim 5, characterized in that: the chemical sunscreen is ethylhexyl methoxycinnamate. 8. The use according to claim 5, characterized in that: the physicochemical compound sunscreen is a mixture of titanium dioxide and ethylhexyl methoxycinnamate. 9. The use according to claim 6, characterized in that: wherein said fig fruit extract accounts for 0.01%-1.13% by weight in sunscreen products. 10. The use according to claim 7, characterized in that: wherein said fig fruit extract accounts for 0.01%-1.11% by weight in sunscreen products.