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CN109247534A - A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet and preparation method thereof - Google Patents

A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet and preparation method thereof Download PDF

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Publication number
CN109247534A
CN109247534A CN201811010358.7A CN201811010358A CN109247534A CN 109247534 A CN109247534 A CN 109247534A CN 201811010358 A CN201811010358 A CN 201811010358A CN 109247534 A CN109247534 A CN 109247534A
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China
Prior art keywords
vegetables
fruits
powder
oral disnitegration
disnitegration tablet
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Inventor
刘峰
李克文
栾庆民
贾慧慧
秦孝发
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Baolingbao Biology Co Ltd
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Baolingbao Biology Co Ltd
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Priority to CN201811010358.7A priority Critical patent/CN109247534A/en
Publication of CN109247534A publication Critical patent/CN109247534A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01Instant products; Powders; Flakes; Granules
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/37Sugar alcohols
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention provides a kind of high stabilities and high dietary-fiber fruits and vegetables oral disnitegration tablet, it is made from the following raw materials in parts by weight: fruit vegetable powder 40%-60%, Sugarless poly-glucose 20%-30%, resistant dextrin 10%-15%, maltodextrin 5%-10%, sugar alcohol sweetener 5%-10%, wherein fruit vegetable powder is fruits and vegetables Ultramicro-powder.The present invention also provides a kind of methods for preparing high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet: fresh fruit of vegetables being sliced and is dried, it is ground into fruits and vegetables Ultramicro-powder, again with Sugarless poly-glucose, resistant dextrin, maltodextrin, maltitol by weight mixing, adhesive is added, it is granulated, 20-25 mesh is crossed, tabletting is dried.Fruits and vegetables oral disnitegration tablet provided by the invention, contain the up to total dietary fiber of 50%-65%, the oral disnitegration tablet prepared using common auxiliary material is superior in friability, hardness, disintegration time limited and stability, cool taste simultaneously, disintegration is rapid, the smell of fruits is very sweet, no bitter taste, sand type and soapy feeling.

Description

A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet and preparation method thereof
Technical field
The present invention relates to field of health care food, and in particular to a kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet And preparation method thereof.
Background technique
Dietary fiber is a kind of carbohydrate that cannot be digested, and can be divided into soluble dietary by dissolubility Fiber and insoluble diedairy fiber are the indispensable the seventh-largest nutrients of healthy diet, are keeping the strong of digestion Play important role in health.Dietary fiber can clean wall of digestive, enhance digestive function, while can dilute the cause in food Cancer substance and noxious material protect fragile alimentary canal, accelerate excretion of cholesterol, in prevent constipation, adjust intestinal flora, auxiliary With good effect in terms of inhibiting tumour, adjusting blood pressure and blood lipoid, obesity controlling.
Fruits and vegetables is the important sources of the daily required nutrient of the human bodies such as vitamin, minerals and dietary fiber, will Fresh fruits and vegetables are directly processed into fruit vegetable powder, are the new trends of garden stuff processing in recent years.Fruit vegetable powder is good with storage-stable, transports Defeated at low cost, the full of nutrition, unique advantages such as comprehensive utilization ratio is high, product category is abundant, can be used as the substitute of fresh fruit of vegetables, Meet the needs of such as infant, the elderly, gastrointestinal disease patient, geological prospecting personnel and space flight navigating officer's special population. Studies have shown that the fruits and vegetables handled using superfine communication technique, total dietary fiber are greatly promoted, this is because pulverizing Plant cell wall can be destroyed, more soluble dietary fibers are dissolved out.
Oral disnitegration tablet is a kind of novel solid quick releasing formulation researched and developed on the basis of dispersible tablet and chewable tablets in recent years, Without being delivered with water, saliva can make it, and fater disintegration is dissolved out in the oral cavity, is taken after can also putting disintegration in water, it has also become piece One of the hot spot of agent exploitation.Oral disnitegration tablet has convenient to take, fast, the liver small to esophagus and gastrointestinal tract mucosa irritation of absorption Dirty first pass effect is small, can play the features such as local targeted therapy effect, is applied to field of pharmaceutical preparations, but the prior art In do not occur also by the dosage form be applied to health food.The dosage form is in the preparation there are the following problems: need largely can not The disintegrating agent being utilized can be only achieved speed and collapse effect, and activity substance content is very low;It is for example hard to need to be added lubricant not soluble in water Fatty acid magnesium is taken as auxiliary material and is also easy to produce soapy feeling, sand type, poor taste;Its quality index, as hardness, disintegration time limited, Friability and stability etc. are difficult to control.
Summary of the invention
To solve the above-mentioned problems, on the one hand, the present invention provides a kind of high stabilities and high dietary-fiber fruits and vegetables oral cavity Disintegrated tablet is made from the following raw materials in parts by weight: fruit vegetable powder 40%-60%, Sugarless poly-glucose 20%-30%, resistant dextrin 10%-15%, maltodextrin 5%-10%, sugar alcohol sweetener 5%-10%, wherein fruit vegetable powder is fruits and vegetables Ultramicro-powder.
Further, fruits and vegetables Ultramicro-powder, Sugarless poly-glucose, resistant dextrin, maltodextrin, sugar alcohol sweetener partial size not More than 74 microns.
Further, the partial size of fruits and vegetables Ultramicro-powder is no more than 50 microns.Preferably, the partial size of fruits and vegetables Ultramicro-powder is no more than It is 30 microns, 10-25 microns more preferable.The partial size of ultra micro helps speed up disintegration rate, and dissolution faster, does not stay residue when taking, Mouthfeel is more preferable.Preferably, the content of fruits and vegetables Ultramicro-powder is 42%-52%.
Further, fruit vegetable powder is selected from one of apple powder, strawberry powder, kiwi fruit powder, blueberry powder or a variety of mixing. Preferably, wherein any two kinds and/or any three kinds and/or four kinds of mixing be can be.It in other implementations, can be with Other are selected to be rich in the fruits and vegetables of dietary fiber, but from the point of view of mouthfeel evaluation feedback, four kinds of fruits and vegetables tastes that the present invention selects are easier to Received by most of crowds.
Further, Sugarless poly-glucose content is 25%-29%, and the content of resistant dextrin is 11%-14%.Resistance paste Essence is low with the heat of Sugarless poly-glucose, and dissolubility is good, facilitates to promote disintegration rate while promoting dietary fiber content And mouthfeel.Experimental data shows that the content of especially resistant dextrin is 11%-14%, and the content of Sugarless poly-glucose is When 25%-29%, the disintegration effect and stability of obtained high dietary-fiber fruits and vegetables oral disnitegration tablet are more preferable.
Further, sugar alcohol sweetener is maltitol, and the dextrose equivalent value of maltodextrin is 10-25.Wherein, malt Sugar alcohol may make oral disnitegration tablet cool taste, and dextrose equivalent value (being commonly called as DE value) is the dissolubility of the maltodextrin of 10-25 Preferably, suitable addition maltitol and maltodextrin help to promote mouthfeel while reducing caloric intake.
On the other hand, the present invention also provides a kind of sides for preparing high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet Method, wherein fruits and vegetables oral disnitegration tablet is made from the following raw materials in parts by weight: fruit vegetable powder 40%-60%, Sugarless poly-glucose 20%-30%, resistant dextrin 10%-15%, maltodextrin 5%-10%, sugar alcohol sweetener 5%-10%, wherein fruit vegetable powder be Fruits and vegetables Ultramicro-powder;
Preparation method includes:
Fresh fruit of vegetables is sliced and is dried, is ground into fruits and vegetables Ultramicro-powder, then paste with Sugarless poly-glucose, resistant dextrin, malt Essence, maltitol are added adhesive, are granulated, cross 20-25 mesh, dry tabletting by weight mixing.
Further, fruits and vegetables Ultramicro-powder, Sugarless poly-glucose, resistant dextrin, maltodextrin, maltitol are by weight mixed Before even, 200-300 mesh is crossed.Preferably, before above-mentioned raw materials mix, it is ground into Ultramicro-powder.In one embodiment, fruits and vegetables are super Micro mist crosses 300 meshes, remaining raw material crosses 200 meshes;In another embodiment, 200 meshes are crossed before all raw materials mix.
Further, adhesive is 95% ethyl alcohol of 3-15 parts by weight.
Further, drying temperature is 40-50 DEG C, is dried to moisture≤3%.
A kind of high stability provided by the invention and high dietary-fiber fruits and vegetables oral disnitegration tablet, have the following beneficial effects:
1, with the total dietary fiber of high-content, after measured, the total diet of fruits and vegetables oral disnitegration tablet provided by the invention is fine Dimension hplc is 50%-65%, can be used as supplement of the health food for human body ordinary meal fiber.
2, common medicinal disintegrating agent is replaced with a large amount of fruit vegetable powders rich in dietary fiber and soluble dietary fiber, reached To utilization can be fully absorbed while being disintegrated effect, the active material utilization of traditional oral disintegrated tablet is substantially increased.
3, by disintegration effect measuring and stability contrast data it is found that fruits and vegetables oral disnitegration tablet provided by the invention is in friability The oral disnitegration tablet prepared using general auxiliary material is superior in degree, hardness, disintegration time limited and stability, more preferably, The content of resistant dextrin is 11%-14%, when Sugarless poly-glucose content is 25%-29%, the fruits and vegetables oral disnitegration tablet of preparation Disintegration effect and stability it is more preferable.
4, by pulverizing and crossing mesh before mixing, the partial size of ultra micro not only increases disintegration effect, more mentions raw material Mouthfeel is risen, mouthfeel experimental evaluation shows fruits and vegetables oral disnitegration tablet disintegration provided by the invention rapidly, cool taste, and fruity is dense It is strongly fragrant, no bitter taste, sand type and soapy feeling.
Specific embodiment
Below with reference to embodiment, technical scheme is described further.In the following description, it gives big Measure concrete details so as to provide a more thorough understanding of the present invention.However, aobvious and easy to those skilled in the art See, the present invention may not need one or more of these details and be carried out.In other examples, in order to avoid with this Invention is obscured, and some technical characteristics well known in the art are not described.
As without explaining separately, the raw material in specification embodiment is bought or is made by oneself by commercial sources, wherein fruit vegetable powder It is preferred that homemade fruits and vegetables Ultramicro-powder, is crushed by the micronizer of model HMB-700S and is made.
A kind of method for preparing high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet provided in this specification, specifically Steps are as follows:
(1) fresh fruit of vegetables is sliced, is dried to moisture≤5%, crush 10min with micronizer, cross 300 meshes, it is standby With;
(2) Sugarless poly-glucose, resistant dextrin, maltodextrin, maltitol micronizer are crushed into 10min, mistake 200 meshes, it is spare;
(3) proportion by above-mentioned spare micro mist by weight, weighs raw material, is uniformly mixed, and 3-15 parts by weight are added 95% ethyl alcohol is mixed and is granulated as adhesive;
(4) particle crosses 20-25 mesh, is dried to moisture≤3% in 40-50 DEG C, with tablet press machine direct tablet compressing.
In one embodiment, fruits and vegetables Ultramicro-powder crosses 300 meshes, remaining raw material crosses 200 meshes;In another embodiment party In formula, all raw materials cross 200 meshes before mixing.
The following example is all made of the above method and is made, therefore only lists raw material and its proportion in embodiments, specifically Preparation method repeats no more.
Embodiment 1
A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet, the raw material including following parts by weight: apple ultra micro Powder 50.3%, Sugarless poly-glucose 25.5%, resistant dextrin 13.2%, maltodextrin 5.7%, maltitol 5.3%.
Embodiment 2
A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet, the raw material including following parts by weight: strawberry ultra micro Powder 48.3%, Sugarless poly-glucose 25.5%, resistant dextrin 13.2%, maltodextrin 7.7%, maltitol 5.3%.
Embodiment 3
A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet, the raw material including following parts by weight: blueberry ultra micro Powder 45.3%, Sugarless poly-glucose 25.5%, resistant dextrin 13.2%, maltodextrin 7.7%, maltitol 8.3%.
Embodiment 4
A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet, the raw material including following parts by weight: Kiwi berry is super Micro mist 42.3%, Sugarless poly-glucose 27.5%, resistant dextrin 15.2%, maltodextrin 6.7%, maltitol 8.3%.
Embodiment 5-10
The raw material proportioning of the fruits and vegetables oral disnitegration tablet of embodiment 5-10 is shown in Table 1, wherein setting is adjusted in embodiment 7-10 The content of Sugarless poly-glucose and resistant dextrin is compared with embodiment 1-6.
The raw material proportioning of the fruits and vegetables oral disnitegration tablet of 1 embodiment 5-10 of table preparation
Comparative example 1
A kind of oral disnitegration tablet, the raw material including following parts by weight: apple powder 10%, microcrystalline cellulose 30%, hydroxypropyl are fine Dimension element 17%, crospovidone 15%, croscarmellose sodium 20%, lactose 5%, magnesium stearate 1%, aspartame 2%.
Above-mentioned raw materials are crossed into 80 meshes respectively, after being weighed by quality proportioning, is uniformly mixed, 95% second of 3 parts by weight is added Alcohol is mixed and is granulated, particle crosses 20 meshes, is dried to moisture≤3% in 45 DEG C, with tablet press machine direct tablet compressing as adhesive.
Comparative example 2
A kind of oral disnitegration tablet, the raw material including following parts by weight: strawberry powder 21%, microcrystalline cellulose 26%, hydroxypropyl are fine Dimension element 17%, crospovidone 12%, croscarmellose sodium 16%, lactose 5%, magnesium stearate 1%, aspartame 2%.
Above-mentioned raw materials are sieved with 100 mesh sieve respectively, after being weighed by quality proportioning, is uniformly mixed, 95% second of 3 parts by weight is added Alcohol is mixed and is granulated, particle crosses 25 meshes, is dried to moisture≤3% in 45 DEG C, with tablet press machine direct tablet compressing as adhesive.
Above-described embodiment and comparative example are made 500 respectively.In order to better understand the present invention, respectively from each embodiment and If taking dry plate in comparative example, its dietary fiber content, mouthfeel, friability, hardness, disintegration time limited and stability are detected, with this To illustrate beneficial effects of the present invention.Wherein, the average value of institute's measured data sampling notebook data, no longer separately says in detection method It is bright.
1, dietary fiber content detects
The detection method of total dietary fiber, referring to the second method in GB/T 22224-2008: enzymatic gravimetric method-liquid phase Chromatography.The total dietary fiber measured includes the soluble dietary that insoluble diedairy fiber, high molecule mass precipitate in ethanol Fiber and low molecule quality dissolve in the soluble resistant dextrin of ethyl alcohol.
2, friability is tested
The detection method of friability, referring to Chinese Pharmacopoeia tablet friability inspection technique: taking 10 oral disnitegration tablets to be put into crisp Broken degree instrument, with 25 revs/min of 4 clock of rotational speed, it is qualified product no more than 1% that the percentage for measuring loss of weight, which is friability,. Wherein, friability instrument used in this specification obtains II type of model CS-, is purchased from Tianjin Jing Tuo instrument Science and Technology Ltd..
3, hardness and disintegration time limited
The hardness tester progress Determination of Hardness of hardness detected using Tianjin optical instrument factory, replication 10, gained Average value according to hardness uses;The detection method of disintegration is surveyed referring to the lower regulation of Chinese Pharmacopoeia annex X A of version two in 2010 It is fixed.
The total dietary fiber of embodiment 1-10 and comparative example 1-2 and disintegration effect data are shown in Table 2.
2 total dietary fiber of table and disintegration effect
Total dietary fiber/% Friability/% Hardness/N Disintegration time limited/s
Embodiment 1 56.64 0.2 34 11
Embodiment 2 54.02 0.5 35 12
Embodiment 3 64.87 0.4 34 15
Embodiment 4 55.24 0.3 32 13
Embodiment 5 58.47 0.8 34 14
Embodiment 6 53.17 0.6 33 16
Embodiment 7 53.26 0.8 19 30
Embodiment 8 50.98 0.7 21 31
Embodiment 9 61.85 0.4 33 28
Embodiment 10 59.75 0.5 32 27
Comparative example 1 4.34 1.2 26 36
Comparative example 2 8.34 0.9 28 29
From the data in table 2, it can be seen that all in all, the total dietary fiber that embodiment measures is between 50%-65%, much Higher than the total dietary fiber of comparative example.It is found by the disintegration effect of comparative example 1-6 and embodiment 7-10, embodiment 7-10 is not so good as in hardness and on disintegration time limited the effect of embodiment 1-6 due to the changes of contents of Sugarless poly-glucose and resistant dextrin Fruit is good, thus, the content of resistant dextrin is 11%-14%, when Sugarless poly-glucose content is 25%-29%, preparation Fruits and vegetables oral disnitegration tablet more preferable, the too high or too low content of disintegration effect, have different degrees of influence to disintegration effect. Data can obtain in analytical table simultaneously, and relative to embodiment 7-10 and comparative example 1-2, the friability of embodiment 1-6 is respectively less than 1%, Hardness is all larger than 30N, and disintegration time limited is respectively less than 20s, has better friability, higher hardness and faster disintegration time limited, Meet the standard in Chinese Pharmacopoeia about disintegrating agent, also show fruits and vegetables oral disnitegration tablet prepared by the present invention, do not need using Conventional medicinal disintegrating agent can also reach disintegration effect well.
4, mouthfeel is tested
Mouthfeel experiment in this specification, is the Orally disintegrating by 100 healthy volunteers to embodiment and comparative example After piece progress mouth is tasted, then completed from several dimensions evaluations such as disintegration rate, sugariness, fragrance, sand type, soapy feeling, bitter taste.System Meter evaluation result can obtain, and the volunteer more than 95% thinks, the mouthfeel of the fruits and vegetables oral disnitegration tablet of embodiment preparation is very refrigerant Palatable, rapidly, sugariness is relatively low, and fruit aroma is strong, no bitter taste, sand type and soapy feeling for disintegration after being placed on tongue.Specifically It the results are shown in Table 3.
3 mouthfeel experimental evaluation of table comparison
5, stability experiment
10 progress stability tests are respectively taken from embodiment 1-10 and comparative example 1-2, it is therefore intended that monitor each example at 1 Month, 2 months, the extent of damage of total dietary fiber after 3 months.Wherein, acceleration environment is 40 DEG C of temperature, relative humidity 70%RH.Concrete outcome is shown in Table 4.
4 stability contrast of table
By the data of table 4 it is found that under acceleration conditions, total dietary fiber of the embodiment 1-6 after 3 months has lost 2% or so, accounting about 3.5%, and embodiment 7 and embodiment 8 have lost 10% or so, accounting about 20% and is implemented embodiment 9 Example 10 has lost 13% or so, and accounting about 22%, comparative example 1 has lost 4.11%, and accounting 94.7%, comparative example 2 has lost 5.46%, accounting 65.5%, it can be seen that, the stability of embodiment 1-6 is higher than the stability of embodiment 7-10, while obvious high In the stability of comparative example 1-2, all in all, embodiment has higher stability compared to comparative example.
The above description is only an example of the present application, is not intended to limit this application.For those skilled in the art For, various changes and changes are possible in this application.All any modifications made within the spirit and principles of the present application are equal Replacement, improvement etc., should be included within the scope of the claims of this application.

Claims (10)

1. a kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet, which is characterized in that by the raw material system of following parts by weight At: fruit vegetable powder 40%-60%, Sugarless poly-glucose 20%-30%, resistant dextrin 10%-15%, maltodextrin 5%-10%, Sugar alcohol sweetener 5%-10%, the fruit vegetable powder are fruits and vegetables Ultramicro-powder.
2. fruits and vegetables oral disnitegration tablet according to claim 1, which is characterized in that the fruits and vegetables Ultramicro-powder, the poly- grape of sugar-free Sugar, resistant dextrin, maltodextrin, sugar alcohol sweetener partial size be no more than 74 microns.
3. fruits and vegetables oral disnitegration tablet according to claim 2, which is characterized in that the partial size of the fruits and vegetables Ultramicro-powder is no more than 50 microns.
4. fruits and vegetables oral disnitegration tablet according to claim 1, which is characterized in that the fruit vegetable powder is selected from apple powder, strawberry One of powder, kiwi fruit powder, blueberry powder or a variety of mixing.
5. fruits and vegetables oral disnitegration tablet according to claim 1, which is characterized in that the Sugarless poly-glucose content is 25%-29%, the content of resistant dextrin are 11%-14%.
6. -5 any fruits and vegetables oral disnitegration tablet according to claim 1, which is characterized in that the sugar alcohol sweetener is malt Sugar alcohol, the dextrose equivalent value of the maltodextrin are 10-25.
7. a kind of method for preparing high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet, which is characterized in that
The fruits and vegetables oral disnitegration tablet, is made from the following raw materials in parts by weight: fruit vegetable powder 40%-60%, Sugarless poly-glucose 20%-30%, resistant dextrin 10%-15%, maltodextrin 5%-10%, sugar alcohol sweetener 5%-10%, the fruit vegetable powder are Fruits and vegetables Ultramicro-powder;
The described method includes:
Fresh fruit of vegetables is sliced and is dried, is ground into fruits and vegetables Ultramicro-powder, then with Sugarless poly-glucose, resistant dextrin, maltodextrin, wheat Adhesive is added by weight mixing in bud sugar alcohol, is granulated, and crosses 20-25 mesh, dries tabletting.
8. preparation method according to claim 7, which is characterized in that the fruits and vegetables Ultramicro-powder, Sugarless poly-glucose, resistance Before dextrin, maltodextrin, maltitol are by weight mixing, 200-300 mesh is crossed.
9. preparation method according to claim 7, which is characterized in that described adhesive is 95% second of 3-15 parts by weight Alcohol.
10. preparation method according to claim 7, which is characterized in that the drying temperature is 40-50 DEG C, is dried to water Divide≤3%.
CN201811010358.7A 2018-08-31 2018-08-31 A kind of high stability and high dietary-fiber fruits and vegetables oral disnitegration tablet and preparation method thereof Pending CN109247534A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113499364A (en) * 2021-08-24 2021-10-15 北京杏林药业有限责任公司 Preparation process of cortex magnoliae officinalis with ginger

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050100599A1 (en) * 2001-05-10 2005-05-12 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
CN101449755A (en) * 2007-12-07 2009-06-10 上海博程膳食纤维发展有限公司 Sugarless poly-glucose and production method thereof
US20100278930A1 (en) * 2007-12-28 2010-11-04 Sawai Pharmaceutical Co., Ltd. Oral cavity disintegrating tablet and method of producing the same
CN105248819A (en) * 2015-11-10 2016-01-20 苏州工业园区尚融科技有限公司 Maca dietary fiber sugar-free refreshing candy and preparation method thereof
CN106172795A (en) * 2016-06-16 2016-12-07 呼伦贝尔海乳乳业有限责任公司 A kind of functional milk tea powder resisting haze
CN106418337A (en) * 2016-12-12 2017-02-22 保龄宝生物股份有限公司 Fruit and vegetable meal replacement tablets with cool and refresh mouthfeel
CN106858438A (en) * 2017-02-21 2017-06-20 天津科大智慧生物科技有限公司 Fruits and vegetables elite diet nutritional powder and preparation method thereof
CN108208184A (en) * 2017-12-28 2018-06-29 保龄宝生物股份有限公司 A kind of production method of high-fine sugar-free type soybean peptide local flavor beverage

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050100599A1 (en) * 2001-05-10 2005-05-12 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
CN101449755A (en) * 2007-12-07 2009-06-10 上海博程膳食纤维发展有限公司 Sugarless poly-glucose and production method thereof
US20100278930A1 (en) * 2007-12-28 2010-11-04 Sawai Pharmaceutical Co., Ltd. Oral cavity disintegrating tablet and method of producing the same
CN105248819A (en) * 2015-11-10 2016-01-20 苏州工业园区尚融科技有限公司 Maca dietary fiber sugar-free refreshing candy and preparation method thereof
CN106172795A (en) * 2016-06-16 2016-12-07 呼伦贝尔海乳乳业有限责任公司 A kind of functional milk tea powder resisting haze
CN106418337A (en) * 2016-12-12 2017-02-22 保龄宝生物股份有限公司 Fruit and vegetable meal replacement tablets with cool and refresh mouthfeel
CN106858438A (en) * 2017-02-21 2017-06-20 天津科大智慧生物科技有限公司 Fruits and vegetables elite diet nutritional powder and preparation method thereof
CN108208184A (en) * 2017-12-28 2018-06-29 保龄宝生物股份有限公司 A kind of production method of high-fine sugar-free type soybean peptide local flavor beverage

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113499364A (en) * 2021-08-24 2021-10-15 北京杏林药业有限责任公司 Preparation process of cortex magnoliae officinalis with ginger

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