CN109363802B - Axial spherical aberration progressive modulation type aspheric artificial lens - Google Patents
Axial spherical aberration progressive modulation type aspheric artificial lens Download PDFInfo
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Abstract
The invention discloses an axial spherical aberration progressive modulation type aspheric intraocular lens, which comprises an optical body (1), a first haptic (2) and a second haptic (3), wherein the optical body (1) has an aspheric surface with a non-constant characteristic equation. The optical main body is an optical area with axial spherical aberration progressive modulation, and can keep a certain positive spherical aberration (focal depth) under different pupil sizes, so that the visual quality is improved; meanwhile, high-order aberration can be considered, the method better adapts to slight intraocular lens deviation, the sensitivity of focal power and image quality to an implantation position is reduced, and the reduction of surgical reduction is reduced.
Description
Technical Field
The invention relates to the technical field of artificial lenses, in particular to an axial spherical aberration progressive modulation type aspheric artificial lens designed through a non-constant characterization equation.
Background
The natural lens in the eye, which is a colorless and transparent and very soft lens in the case of a newborn infant, becomes harder and becomes colored with increasing age under the influence of elements such as ultraviolet radiation, and when a person lives over fifty to sixty years old, about thirty percent of the natural lens becomes brownish yellow and turbid and becomes hard, not only loses its function of focusing, but is even completely invisible, and when this happens, the natural lens (i.e., cataractous lens) has to be replaced with an artificial lens to restore the vision of the eye of the cataract patient.
A typical intraocular lens is constructed of an optical lens that focuses light onto the optic nerve to enable it to see objects and a supporting arm that supports its optical zone, centered within the eye, to enable effective focusing. The first important point of early intraocular lens implantation is to help the cataract patients to recover from vision, and spherical intraocular lenses are the main. With the continuous development of scientific technology and the continuous improvement of vision demand in daily life of human beings, the requirements of patients on artificial lens implantation are not only 'visible' but also 'clear'. "see clearly" in optics is to be understood as meaning that the optical system has a high resolution, a good image quality and small wavefront aberrations (small deviations between the actual wavefront and the wavefront in the ideal, unbiased state). Researchers often use Zernike polynomials to quantitatively describe the optical wavefront aberrations of the human eye, where spherical aberration is the most dominant factor affecting the quality of the implanted eye image.
When the peripheral rays of the spherical lens pass through the positive spherical lens, the peripheral rays are refracted to a much greater degree than the central rays, namely, the peripheral power is large, the central power is small, the whole spherical lens presents positive spherical aberration and is difficult to control. The aspheric surface brings more freedom (including curvature radius, cone coefficient, high-order term and the like) to optical design, and the lens can present negative spherical aberration distribution by changing the shape of the edge of the lens and rearranging the convergence capacity of the central area and the edge area to light rays. The cornea of the human eye is known to have positive spherical aberration, and the aspheric artificial lens with negative spherical aberration balances the inherent positive spherical aberration of the human eye, so that the best imaging point can be obtained. Spherical intraocular lenses cannot be realized.
As the distribution of the corneal spherical aberration of the human eyes has difference and conforms to the normal distribution rule, the corneal spherical aberration value of most human eyes is about +0.27 mu m (measured under the condition of 6mm pupil size). Researchers began to design aspherical intraocular lens spherical aberration values of different spherical aberrations to be approximately between-0.27 um and 0um, as in patents US4504982, US5050981, AU2007247491, EP2189134, CA2590166, etc. All the artificial lenses with negative spherical aberration distribution can only ensure that the aim of reserving a certain positive spherical aberration is achieved at the pupil position of 6mm, and the reserved residual positive spherical aberration can not meet the requirement at the positions of small and medium pupils.
Disclosure of Invention
In view of the above problems in the prior art, the applicant of the present invention provides a design of an axial spherical aberration progressive modulation type aspherical intraocular lens. The optical body of the present invention has an aspheric surface with a non-constant characterization equation. The design can keep a certain positive spherical aberration (focal depth) under different pupil sizes, and the visual quality is improved; meanwhile, high-order aberration can be considered, the slight intraocular lens deviation is better adapted, the sensitivity of focal power and image quality to the implantation position is reduced, and the surgical reduction is reduced.
The technical scheme of the invention is as follows:
an axial spherical aberration progressive modulation type aspheric intraocular lens comprises an optical main body (1), a first supporting loop (2) and a second supporting loop (3), wherein the optical main body (1), the first supporting loop (2) and the second supporting loop (3) are of an integrated structure, are made of the same material and are integrally formed, the optical main body (1) is composed of two optical surfaces, one optical surface is a spherical surface, and the other surface is an aspheric surface with a non-constant representation equation;
the aspheric surface determining method comprises the following steps: establishing an arbitrary space rectangular coordinate system by taking the vertex of the optical surface as an origin O and the optical axis as a coordinate Z axis, wherein the abscissa X axis and the coordinate Y axis of the coordinate system are tangent to the optical surface, and the projection curve of the aspheric surface on the Y-Z plane has a non-constant characterization equation, which is as follows:
wherein z isn(yn) Is the expression of the projection curve of the aspheric surface on a two-dimensional coordinate system plane Y-Z, c is the reciprocal of the curvature radius of the basic spherical surface of the aspheric surface, YnIs the perpendicular distance of any point on the curve from the Z axis of the coordinate, AiIs a coefficient of a higher order term of an aspherical surface, QnA conic constant which is aspheric;
curve a, curve b, curve c … curve n represents a family of known different spherical aberration distributions ranging from 0um to-0.2 um, wherein each curve corresponds to a certain Q value and is different from each other, respectively Qa、Qb、Qc…QnThe series Q values can be summarized from the spherical aberration envelope as a function of y:
α, β, χ and δ are constants, QnIs defined by the spherical aberration envelope, by any four known points (y)a,Qa)、(yb,Qb)、(yc,Qc)、(yd,Qd) The system of equations is brought into solution,α, β, χ, δ are obtained, the system of equations is as follows:
the envelope curve of the axial progressive spherical aberration intersects with the curve family at the point A, B, C … N, and the abscissa of the points corresponds to different pupil diameters 2ya、2yb、2yc…2ynAnd n is an integer from 1 to plus infinity.
From the above aspheric equation family, an array (y) can be obtaineda，za)、(yb，zb)、(yc，zc)、…(yn，zn) All data points of the entire non-constant aspheric surface in the three-dimensional space can be obtained.
The diameter of the effective optical area of the optical main body (1) is 5.5-6.5 mm, and the central thickness of the lens is 0.65-1.25 mm; the thicknesses of the first support loop (2) and the second support loop (3) are 0.15-0.35 mm.
Inclined sawtooth grooves or raised frosts are arranged on the surfaces of the first supporting loop (2) and the second supporting loop (3); the roughness or the height of the oblique saw teeth of the frosting is more than 40 mu m.
The surfaces of the first supporting loop (2) and the second supporting loop (3) are provided with inclined sawtooth grooves or protrusion frosts, the width of each inclined sawtooth groove or protrusion frosts is 0.2-1.0 mm, and the included angle α between the inclined edge of each inclined sawtooth and the plane of the supporting loop is-20 degrees.
The optical main body (1) is made of hydrophobic polyacrylate with the refractive index of 1.48-1.55 and the dispersion coefficient of 40-55.
The optical main body (1), the first support loop (2) and the second support loop (3) act together to achieve the effect of stabilizing the intraocular lens at the position of the implanted eye and better play the role of gradually modulating the axial spherical aberration.
The invention also provides a preparation method of the axial spherical aberration progressive modulation type aspheric intraocular lens, which comprises the following steps:
(1) optical design: first, an envelope of the axially progressive spherical aberration distribution is determined. And fitting an axial spherical aberration progressive modulation spherical aberration distribution curve according to the corneal spherical aberration distribution curve of the human eye and the reserved residual spherical aberration values under different pupil diameters. As shown in fig. 4, the residual spherical aberration is 0um at the pupil diameter of 0-3 mm; at a pupil diameter of 3.5mm, the residual spherical aberration is +0.02 um; the residual spherical aberration is +0.035um below the pupil diameter of 4 mm; the residual spherical aberration is +0.07um at pupil diameter of 4.5mm, and +0.07um at pupil diameter of 5mm, 5.5mm, 6 mm. Thus, the optical main body (1) is ensured to be self-adaptive to the corneal spherical aberration distribution of the human eye under different pupil diameters, and a certain amount of residual positive spherical aberration is reserved after the optical main body is implanted into the eye. Secondly, the progressive spherical aberration modulation aspheric spherical aberration distribution is converted into a curve equation and coordinate points in a three-dimensional space. As shown in fig. 5, the fitted axial spherical aberration progressive modulation spherical aberration distribution curve is plotted in the form of an Envelope curve (geometrically, the Envelope curve (Envelope) of a certain curve family is a curve tangent to each line of the curve family at least at one point). Curve a, curve b, curve c … curve n represents a family of curves with different spherical aberration distributions, and the spherical aberration distribution ranges from 0um to-0.2 um. Wherein each curve corresponds to a certain Q value and is different from each other, and is Qa、Qb、Qc…QnThe series Q values can be summarized from the spherical aberration envelope as a function of y:
α, β, χ and δ are constants, QnIs defined by the spherical aberration envelope,from any four known points (y)a,Qa)、(yb,Qb)、(yc,Qc)、(yd,Qd) Substituting into the solution system of equations to obtain α, β, χ, δ, the system of equations is as follows:
the envelope curve of the axial progressive spherical aberration intersects with the curve family at the point A, B, C … N, and the abscissa of the points corresponds to different pupil diameters 2ya、2yb、2yc…2yn. n is an integer from 1 to plus infinity, an aspheric projection curve within the range of 0 mm-6 mm of the pupil diameter is infinitely micronized, and macroscopically, the aspheric projection curve does not have a constant characterization equation. At pupil diameter 2ynThe non-curved surface local characterization equation is as follows:
from the above aspheric equation family, the coordinate point (y) on the aspheric projection curve on the y-z plane can be obtaineda，za)、(yb，zb)、(yc，zc)、…(yn，zn) And the projection curve is rotationally symmetrical to obtain the aspheric surface distribution of the whole axial spherical aberration progressive modulation. Finally, an initial model is constructed in Zemax, and then optimized for the best expected effect.
(2) Turning and milling: lathing a base refractive lens: writing a lathe program according to the processing parameters of the front and rear optical surfaces of the optical design; turning the optical main body (1) by using a diamond single-point cutting technology; a milling machine program is programmed to mill the optical zone contours and haptic legs with frosted/jagged shapes.
(3) Polishing treatment: the method of low-temperature barrel polishing is adopted.
(4) And (3) testing and verifying: in the simulated eye system, MTF image quality was tested under different optical columns, and the effect of decentration of 0.5mm on image quality was analyzed.
The beneficial technical effects of the invention are as follows:
the aspheric surface of the optical area of the optical main body (1) has a non-constant characterization equation, the optical main body (1) forms an image when being implanted into an eye, and a certain spherical aberration is always kept above a pupil with 3mm different from the traditional design along with the change of the pupil size (mainly, the 3mm is transited to 6mm, and the spherical aberration of the human eye in the pupil diameter with 3mm is generally considered to be zero and is not considered).
The optical zone of the optical main body (1) not only modulates spherical aberration axially, but also eliminates partial high-order aberration such as clover aberration, longitudinal coma, horizontal coma and the like.
The optical area of the optical main body (1) of the invention forms images when being implanted into eyes, always keeps a certain focal depth under the pupil diameter of 3 mm-6 mm, and has better visual quality.
The optical main body (1) of the invention is imaged in the implanted eye, the optical power and the image quality have lower sensitivity to the implantation position, the optical main body better adapts to slight intraocular lens deviation,
after the artificial lens is implanted into human eyes, the postoperative reduction is reduced, and the artificial lens indications of the complex cataract surgery are widened.
Compared with the conventional aspheric surface design, the invention is suitable for wide range of corneal asphericity Q.
Drawings
FIG. 1 is a schematic structural view of example 1 of the present invention;
FIG. 2 is a schematic structural diagram of embodiment 2 of the present invention;
FIG. 3 is a schematic structural diagram according to embodiment 3 of the present invention;
fig. 4 is a schematic diagram of an axial spherical aberration progressive modulation type aspheric surface design according to embodiment 1 of the present invention;
FIG. 5 is a distribution curve of axial spherical aberration progressive modulation type aspheric spherical aberration in embodiment 1 of the present invention;
FIG. 6 is a power profile with pupil for example 1 of the present invention;
FIG. 7 is an optical Modulation Transfer Function (MTF) curve at 3mm diaphragm & eccentricity 0.5mm for example 1 of the present invention;
FIG. 8 is an optical Modulation Transfer Function (MTF) curve at 5mm diaphragm & eccentricity 0.5mm for example 1 of the present invention;
FIG. 9 is a graph of Contrast Sensitivity (CSF) at 5mm diaphragm & eccentricity 0.5mm for example 1 of the present invention;
FIG. 10 is a graph showing a comparison of spherical aberration distribution curves of examples 1, 2 and 3 of the present invention.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings and examples.
Example 1
As shown in FIG. 1, an aspherical intraocular lens of axial spherical aberration progressive modulation type, the intraocular lens comprising an optical body (1), a first haptic (2) and a second haptic (3), the optical body 1 having an aspherical surface of a non-constant characteristic equation at a pupil diameter 2ynThe local characterization equation of the aspheric surface is as follows:
at pupil diameter 2ya＝3mm、2yb＝3.5mm、2yc＝4mm、2yn6mm away, aspheric surface Qa、Qb、Qc、QnRespectively are-3.3, -6.2, -9.5 and-13.5,
the optical main body 1, the first supporting loop 2 and the second supporting loop 3 are of an integrated structure, are made of the same material and are integrally formed;
the surfaces of the first supporting loop 2 and the second supporting loop 3 are provided with inclined sawtooth grooves; the height of the oblique saw teeth is more than 40 μm.
The diameter of the effective optical area of the optical main body 1 is 6.0mm, and the central thickness of the lens is 0.67 mm; the thicknesses of the first support loop 2 and the second support loop 3 are both 0.15 mm;
the optical body 1 is made of a hydrophobic polyacrylate with a refractive index of 1.544 and an abbe number of 42.
The surfaces of the first supporting loop 2 and the second supporting loop 3 are provided with a plurality of inclined sawtooth grooves, the width of each inclined sawtooth groove is 0.2mm, and the included angle α between the inclined edge of each inclined sawtooth and the plane of the corresponding supporting loop is 20 degrees.
The design idea and the preparation method of the artificial lens are as follows:
(1) the design scheme is as follows: the axial spherical aberration progressive modulation type aspheric artificial lens is implanted with the residual spherical aberration of the eye maintained at +0.07um within the change range of the pupil diameter of 2 mm-6 mm;
(2) optical design: first, an envelope of the axially progressive spherical aberration distribution is determined. And fitting an axial spherical aberration progressive modulation spherical aberration distribution curve according to the corneal spherical aberration distribution curve of the human eye and the reserved residual spherical aberration values under different pupil diameters. As shown in fig. 4, the residual spherical aberration is 0um at the pupil diameter of 0-3 mm; at a pupil diameter of 3.5mm, the residual spherical aberration is +0.02 um; the residual spherical aberration is +0.035um at a pupil diameter of 4 mm; the residual spherical aberration is +0.07um under the pupil diameter of 4.5 mm; the residual spherical aberration is +0.07um under the pupil diameters of 5mm, 5.5mm and 6 mm. Thus, the optical main body (1) is ensured to be self-adaptive to the corneal spherical aberration distribution of the human eye under different pupil diameters, and a certain amount of residual positive spherical aberration is reserved after the optical main body is implanted into the eye. Secondly, the progressive spherical aberration modulation aspheric spherical aberration distribution is converted into a curve equation and coordinate points in a three-dimensional space. As shown in fig. 5, the fitted axial spherical aberration progressive modulation spherical aberration distribution curve is plotted in the form of an Envelope curve (geometrically, the Envelope curve (Envelope) of a certain curve family is a curve tangent to each line of the curve family at least at one point). Curve a, curve b, curve c … curve n represents different spherical differentialsThe spherical aberration distribution of the curve family of the cloth is from 0um to-0.2 um. Wherein each curve corresponds to a certain Q value and is different from each other, and is Qa、Qb、Qc…QnThe series Q values can be summarized from the spherical aberration envelope as an equation for y:
the envelope curve of the axial progressive spherical aberration intersects with the curve family at the point A, B, C … N, and the abscissa of the points corresponds to different pupil diameters 2ya、2yb、2yc…2yn. n is an integer from 1 to plus infinity, an aspheric projection curve within the range of 0 mm-6 mm of the pupil diameter is infinitely micronized, and macroscopically, the aspheric projection curve does not have a constant characterization equation. At pupil diameter 2ya、2yb、2yc…2ynThe local characterization equations of the non-curved surface are respectively as follows:
from the above aspheric equation family, the coordinate point (y) on the aspheric projection curve on the y-z plane can be obtaineda，za)、(yb，zb)、(yc，zc)、…(yn，zn) And the projection curve is rotationally symmetrical to obtain the aspheric surface distribution of the whole axial spherical aberration progressive modulation. Finally, an initial model is constructed in Zemax, and then optimized for the best expected effect.
(3) Lathing a base refractive lens: writing a lathe program according to the parameters of the designed optical zone; turning a wafer artificial lens by using a diamond single-point cutting technology; and programming a milling machine to mill the shape of the optical area and the ground loop feet.
(4) And finally, polishing to obtain the artificial lens with qualified optical surface.
(5) Analytical testing in eye model
Analysis and discussion of results:
the constant spherical aberration design of the axial progressive modulation type aspheric artificial lens effectively improves the tolerance of the focal power of the artificial lens to an implantation position. As can be seen from fig. 6, when the pupil radius is within the range of 0-1.5 mm, the change of the focal power of different designs is relatively slow, but the focal power curve of the axial progressive modulation type aspheric artificial lens is more gradual; in the range of pupil radius of 1.5-3 mm, the focal power of the axial progressive modulation type aspheric artificial lens is gradually changed from one stage to the next, and the focal power curves of the SN60WF design and the ZCB00 design are completely steep and obvious. It can be concluded that the eccentricity of the intraocular lens implantation has less influence on the focal power of the axially progressive modulated aspherical intraocular lens, and that the variation of the focal power of the axially progressive modulated aspherical intraocular lens is minimal at the same eccentricity, which helps the patient to achieve the best corrected vision.
The axial spherical aberration progressive design of the axial progressive modulation type aspheric artificial lens effectively improves the tolerance of the imaging quality of the retina of the artificial lens to an implantation position. As shown in fig. 7, the Modulation Transfer Function (MTF) curve of the axial progressive modulation type aspherical intraocular lens in the 3mm diaphragm & decentration 0.5mm state is significantly superior to the SN60WF design and the ZCB00 design. Meanwhile, in the state of a 5mm diaphragm & eccentricity 0.5mm, the Modulation Transfer Function (MTF) curve of the axial progressive modulation type aspheric artificial lens is superior to that of the SN60WF design and the ZCB00 design in the figure 8; the predicted implanted eye vision of the axially progressive modulated aspheric intraocular lens in the Contrast Sensitivity Function (CSF) curve (fig. 9) was 0.98, which is also superior to the predicted vision of SN60WF design of 0.85 and the predicted vision of ZCB00 design of 0.76.
Therefore, the axial progressive modulation type aspheric artificial lens overcomes the design defects of Alcon and AMO, and keeps constant positive spherical aberration in the range of large pupils (3-6 mm). The design effectively improves the visual quality of the implanted eye and reduces the sensitivity of the optical power and the image quality to the implanted position.
Example 2
As shown in figure 2, the axial spherical aberration progressive modulation type aspherical artificial lens comprises an optical body (1) and a first lensA haptic (2) and a second haptic (3), the optical body 1 having an aspherical surface of a non-constant characteristic equation at a pupil diameter 2ynThe non-curved surface local characterization equation is as follows:
at pupil diameter 2ya＝3mm、2yb＝3.5mm、2yc＝4mm、2yn6mm away, aspheric surface Qa、Qb、Qc、QnRespectively are-10.6, -20.2, -28.4 and-39.7
The optical main body 1, the first supporting loop 2 and the second supporting loop 3 are of an integrated structure, are made of the same material and are integrally formed;
the surfaces of the first supporting loop 2 and the second supporting loop 3 are provided with inclined sawtooth grooves; the height of the oblique saw teeth is more than 40 μm.
The diameter of the effective optical area of the optical main body 1 is 6.0mm, and the central thickness of the lens is 0.67 mm; the thicknesses of the first support loop 2 and the second support loop 3 are both 0.15 mm;
the optical body 1 is made of hydrophobic polyacrylate with a refractive index of 1.544 and an abbe number of 45.
The surfaces of the first supporting loop 2 and the second supporting loop 3 are provided with a plurality of inclined sawtooth grooves, the width of each inclined sawtooth groove is 0.2mm, and the included angle α between the inclined edge of each inclined sawtooth and the plane of the corresponding supporting loop is 20 degrees.
The preparation method of the artificial lens comprises the following steps:
(1) the design scheme is as follows: the axial spherical aberration progressive modulation type aspheric artificial lens is implanted with the residual spherical aberration of the eye maintained at +0.1um within the change range of the pupil diameter of 2 mm-6 mm;
(2) optical design: first, an envelope of the axially progressive spherical aberration distribution is determined. According to the corneal spherical aberration distribution curve of human eyes and under different pupil diametersAnd fitting a spherical aberration distribution curve of the axial spherical aberration progressive modulation. As shown in fig. 10, the residual spherical aberration is 0um at the pupil diameter of 0-3 mm; at a pupil diameter of 3.5mm, the residual spherical aberration is +0.025 um; the residual spherical aberration is +0.04um under the pupil diameter of 4 mm; the residual spherical aberration is +0.1um at pupil diameter of 4.5mm, and +0.1um at pupil diameter of 5mm, 5.5mm, 6 mm. Thus, the optical main body (1) is ensured to be self-adaptive to the corneal spherical aberration distribution of the human eye under different pupil diameters, and a certain amount of residual positive spherical aberration is reserved after the optical main body is implanted into the eye. Secondly, the progressive spherical aberration modulation aspheric spherical aberration distribution is converted into a curve equation and coordinate points in a three-dimensional space. As shown in fig. 5, the fitted axial spherical aberration progressive modulation spherical aberration distribution curve is plotted in the form of an Envelope curve (geometrically, the Envelope curve (Envelope) of a certain curve family is a curve tangent to each line of the curve family at least at one point). Curve a, curve b, curve c … curve n represents a family of curves with different spherical aberration distributions, and the spherical aberration distribution ranges from 0um to-0.2 um. Wherein each curve corresponds to a certain Q value and is different from each other, and is Qa、Qb、Qc…QnThe series Q values can be summarized from the spherical aberration envelope as an equation for y:
the envelope curve of the axial progressive spherical aberration intersects with the curve family at the point A, B, C … N, and the abscissa of the points corresponds to different pupil diameters 2ya、2yb、2yc…2yn. n is an integer from 1 to plus infinity, an aspheric projection curve within the range of 0 mm-6 mm of the pupil diameter is infinitely micronized, and macroscopically, the aspheric projection curve does not have a constant characterization equation. At pupil diameter of 2ynThe non-curved surface local characterization equation is as follows:
according to the aspheric equation family, the coordinate point on the aspheric projection curve on the y-z plane can be obtained(ya，za)、(yb，zb)、(yc，zc)、…(yn，zn) And the projection curve is rotationally symmetrical to obtain the aspheric surface distribution of the whole axial spherical aberration progressive modulation. Finally, an initial model is constructed in Zemax, and then optimized for the best expected effect.
(3) Lathing a base refractive lens: writing a lathe program according to the parameters of the designed optical zone; turning a wafer artificial lens by using a diamond single-point cutting technology; and programming a milling machine to mill the shape of the optical area and the ground loop feet.
(4) And finally, polishing to obtain the artificial lens with qualified optical surface.
(5) Analytical testing in eye model
Example 3
As shown in FIG. 3, an aspherical intraocular lens of axial spherical aberration progressive modulation type, the intraocular lens comprising an optical body (1), a first haptic (2) and a second haptic (3), the optical body 1 having an aspherical surface of a non-constant characteristic equation at a pupil diameter of 2ynThe non-curved surface local characterization equation is as follows:
at pupil diameter 2ya＝3.5mm、2yb＝4mm、2yc＝4.5mm、2ynAspheric surface Q at 6mma、Qb、Qc、QnRespectively-12.3, -21.3, -33.4 and-52.5.
The optical main body 1, the first supporting loop 2 and the second supporting loop 3 are of an integrated structure, are made of the same material and are integrally formed;
the surfaces of the first supporting loop 2 and the second supporting loop 3 are provided with inclined sawtooth grooves; the height of the oblique saw teeth is more than 40 μm.
The diameter of the effective optical area of the optical main body 1 is 6.0mm, and the central thickness of the lens is 0.67 mm; the thicknesses of the first support loop 2 and the second support loop 3 are both 0.15 mm;
the optical main body 1 is made of hydrophobic polyacrylate with the refractive index of 1.544 and the dispersion coefficient of 45-55.
The surfaces of the first supporting loop 2 and the second supporting loop 3 are provided with a plurality of inclined sawtooth grooves, the width of each inclined sawtooth groove is 0.2mm, and the included angle α between the inclined edge of each inclined sawtooth and the plane of the corresponding supporting loop is 20 degrees.
The preparation method of the artificial lens comprises the following steps:
(1) the design scheme is as follows: the axial spherical aberration progressive modulation type aspheric artificial lens is implanted with the residual spherical aberration of the eye maintained at +0.05um within the change range of the pupil diameter of 3 mm-6 mm;
(2) optical design: first, an envelope of the axially progressive spherical aberration distribution is determined. And fitting an axial spherical aberration progressive modulation spherical aberration distribution curve according to the corneal spherical aberration distribution curve of the human eye and the reserved residual spherical aberration values under different pupil diameters. As shown in fig. 10, the residual spherical aberration is 0um at the pupil diameter of 0-3 mm; at a pupil diameter of 3.5mm, the residual spherical aberration is +0.0125 um; the residual spherical aberration is +0.025um below the pupil diameter of 4 mm; the residual spherical aberration is +0.05um at pupil diameter of 4.5mm, and +0.05um at pupil diameter of 5mm, 5.5mm, 6 mm. Thus, the optical main body (1) is ensured to be self-adaptive to the corneal spherical aberration distribution of the human eye under different pupil diameters, and a certain amount of residual positive spherical aberration is reserved after the optical main body is implanted into the eye. Secondly, the progressive spherical aberration modulation aspheric spherical aberration distribution is converted into a curve equation and coordinate points in a three-dimensional space. As shown in fig. 5, the fitted axial spherical aberration progressive modulation spherical aberration distribution curve is plotted in the form of an Envelope curve (geometrically, the Envelope curve (Envelope) of a certain curve family is a curve tangent to each line of the curve family at least at one point). Curve a, curve b, curve c … curve n represents a family of curves with different spherical aberration distributions, and the spherical aberration distribution ranges from 0um to-0.2 um. Wherein each curve corresponds to a certain Q value and is different from each other, and is Qa、Qb、Qc…QnThe series Q values can be summarized from the spherical aberration envelope as an equation for y:
the envelope curve of the axial progressive spherical aberration intersects with the curve family at the point A, B, C … N, and the abscissa of the points corresponds to different pupil diameters 2ya、2yb、2yc…2yn. n is an integer from 1 to plus infinity, an aspheric projection curve within the range of 0 mm-6 mm of the pupil diameter is infinitely micronized, and macroscopically, the aspheric projection curve does not have a constant characterization equation. At pupil diameter of 2ynThe non-curved surface local characterization equation is as follows:
from the above aspheric equation family, the coordinate point (y) on the aspheric projection curve on the y-z plane can be obtaineda，za)、(yb，zb)、(yc，zc)、…(yn，zn) And the projection curve is rotationally symmetrical to obtain the aspheric surface distribution of the whole axial spherical aberration progressive modulation. Finally, an initial model is constructed in Zemax, and then optimized for the best expected effect.
(3) Lathing a base refractive lens: writing a lathe program according to the parameters of the designed optical zone; turning a wafer artificial lens by using a diamond single-point cutting technology; and programming a milling machine to mill the shape of the optical area and the ground loop feet.
(4) And finally, polishing to obtain the artificial lens with qualified optical surface.
(5) The test was analyzed in an eye model.
Claims (6)
1. An axial spherical aberration progressive modulation type aspheric intraocular lens comprises an optical main body (1), a first supporting loop (2) and a second supporting loop (3), wherein the optical main body (1), the first supporting loop (2) and the second supporting loop (3) are of an integrated structure, are made of the same material and are integrally formed, and the axial spherical aberration progressive modulation type aspheric intraocular lens is characterized in that the optical main body (1) consists of two optical surfaces, one optical surface is a spherical surface, and the other surface is an aspheric surface with a non-constant representation equation;
the aspheric surface determining method comprises the following steps: the method comprises the following steps of establishing an arbitrary space rectangular coordinate system by taking the vertex of an optical surface as an origin O and an optical axis as a coordinate Z axis, wherein the abscissa X axis and the coordinate Y axis of the coordinate system are tangent to the optical surface, and a projection curve of the aspheric surface on a Y-Z plane has a non-constant characterization equation, which is as follows:
wherein z isn(yn) Is the expression of the projection curve of the aspheric surface on a two-dimensional coordinate system plane Y-Z, c is the reciprocal of the curvature radius of the basic spherical surface of the aspheric surface, YnIs the perpendicular distance of any point on the curve from the Z axis of the coordinate, AiIs a coefficient of a higher order term of an aspherical surface, QnA conic constant which is aspheric;
curves a, b, c … Curve n represents a family of known different spherical aberration distributions ranging from 0 μm to-0.2 μm, each curve corresponding to a determined Q value and being different from each other, respectively Qa、Qb、Qc…QnThe series Q values are summarized from the spherical aberration envelope as a function of y:
α, β, χ and δ are constants, QnIs defined by the spherical aberration envelope, by any four known points (y)a,Qa)、(yb,Qb)、(yc,Qc)、(yd,Qd) Substituting the solution to the system of equations, α, β, χ, δ are obtained, the system of equations is as follows:
the envelope curve of the axial progressive spherical aberration intersects with the curve family at the point A, B, C … N, and the abscissa of the points corresponds to different pupil diameters 2ya、2yb、2yc…2ynN is an integer from 1 to plus infinity;
obtaining an array (y) according to the aspheric equation familya，za)、(yb，zb)、(yc，zc)、…(yn，zn) And obtaining all data points of the whole non-constant aspheric surface in the three-dimensional space.
2. The intraocular lens according to claim 1, characterized by a lenticular/meniscus lens sheet with a diameter of 5.5-6.5 mm and a central thickness of 0.65-1.25 mm in the effective optical zone of the optical body (1); the thicknesses of the first support loop (2) and the second support loop (3) are 0.15-0.35 mm.
3. Intraocular lens according to claim 1, characterized in that the first (2) and second (3) haptic surfaces are provided with oblique sawtooth grooves or raised frosts; the roughness or the height of the oblique saw teeth of the frosting is more than 40 mu m.
4. Intraocular lens according to claim 1, characterized in that the surface of the first and second haptics (2, 3) are provided with a bevel serration groove or protrusion frosting, and the width of the bevel serration groove or protrusion frosting is 0.2-1.0 mm, and the included angle α between the bevel edge of the bevel serration and the plane of the haptic is-20 °.
5. Intraocular lens according to claim 1, characterized in that the optical body (1) is made of hydrophobic polyacrylate with a refractive index of 1.48-1.55 and an abbe number of 40-55.
6. Intraocular lens according to claim 1, characterized in that the optical body (1), the first haptic (2) and the second haptic (3) cooperate to achieve stabilization of the intraocular lens in the eye position, and to better perform progressive modulation of axial spherical aberration.
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| CN112494175B (en) * | 2020-11-25 | 2024-09-24 | 杭州爱晶伦科技有限公司 | Posterior chamber type aspheric intraocular lens with lens |
| CN113040976B (en) * | 2021-03-04 | 2022-06-28 | 天津世纪康泰生物医学工程有限公司 | Ultrathin zero-spherical-aberration implantable myopia lens |
| CN113693779B (en) * | 2021-06-01 | 2023-03-14 | 天津世纪康泰生物医学工程有限公司 | Diffraction type multifocal intraocular lens with targeted light field distribution |
| CN113599021B (en) * | 2021-06-04 | 2024-04-16 | 天津世纪康泰生物医学工程有限公司 | Aspherical intraocular lens for resisting postoperative residual refractive error |
| CN113367840B (en) * | 2021-08-12 | 2021-12-10 | 微创视神医疗科技(上海)有限公司 | Intraocular lens and method of making same |
| CN114246707A (en) * | 2021-11-18 | 2022-03-29 | 天津世纪康泰生物医学工程有限公司 | Free-form surface focal depth expansion type artificial lens with vortex spherical aberration distribution |
| CN115486966B (en) * | 2022-09-14 | 2025-05-02 | 无锡蕾明视康科技有限公司 | A posterior chamber phakic intraocular lens and a preparation method thereof |
| CN117379225B (en) * | 2023-09-11 | 2024-05-28 | 无锡蕾明视康科技有限公司 | Toric astigmatic intraocular lens with reduced rotational sensitivity |
| JP7733277B1 (en) * | 2023-11-14 | 2025-09-02 | ホヤ メディカル シンガポール ピーティーイー エルティーディー | Aspheric intraocular lens, its design method, and its manufacturing method |
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| EP2739248B1 (en) * | 2011-08-04 | 2016-09-14 | BARRETT, Graham David | Extended depth of focus intraocular lenses |
| CN103211664B (en) * | 2012-01-19 | 2015-06-24 | 爱博诺德（北京）医疗科技有限公司 | Posterior chamber type artificial crystal |
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