CN109453144A - With can bloating tendency low density web transmission slot long-acting controlled release composite membrane and its preparation method - Google Patents
With can bloating tendency low density web transmission slot long-acting controlled release composite membrane and its preparation method Download PDFInfo
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- CN109453144A CN109453144A CN201910007686.XA CN201910007686A CN109453144A CN 109453144 A CN109453144 A CN 109453144A CN 201910007686 A CN201910007686 A CN 201910007686A CN 109453144 A CN109453144 A CN 109453144A
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- composite membrane
- microgel
- low density
- bloating tendency
- layer
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- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- JBJWASZNUJCEKT-UHFFFAOYSA-M sodium;hydroxide;hydrate Chemical compound O.[OH-].[Na+] JBJWASZNUJCEKT-UHFFFAOYSA-M 0.000 description 1
- 229940100515 sorbitan Drugs 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to medical composite membrane technology fields, it is especially a kind of with can bloating tendency low density web transmission slot long-acting controlled release composite membrane and its preparation method, composite membrane includes composite membrane main body and the microchannel transfer layer that composite membrane bottom part body is arranged in, composite membrane main body is divided into low-density from inside to outside and wears net supporting structure layer, gel state pressure transmission control layer and limitation film pressure transmission control layer, preparation method includes that limitation film surface modifies processing procedure, the hydrophilic liquid processing procedure of microgel, microgel fluid viscosity is promoted and structure-reinforced processing procedure, matrix low density web supporting structure system journey, low density web supporting structure body immobilization processing procedure and pressure controlling slots encapsulation, simplify making step, and preparation efficiency is substantially improved, the dressing of production provides preferable ventilating performance, so that wound is in good cell growth healing environment；Since dressing is transparent, be conducive to directly observe wound healing situation, to control the treatment situation of wound.
Description
Technical field
The present invention relates to medical composite membrane technology field, it is especially a kind of with can bloating tendency low density web transmission slot length
Imitate controlled release composite membrane and its preparation method.
Background technique
Medicine controlled releasing is to keep constant blood concentration, medicine come quantitative outside release drug at the uniform velocity by clothing film
The function of object control release can be reached by film through control system, body diffusion system, and the Targeting delivery function of drug can
To implement by biology cognitive mechanism, through the means such as mechanism and external control.The composite membrane controlled release of existing drug containing auxiliary material
It is relatively difficult, it can not meet daily medical demand, and in known gel processing procedure, since the reaction to form gel is mixed
Solution state can be presented before carrying out polymerization reaction by closing solution, therefore need to be first contained in container and be carried out polymerization reaction to be formed
Gel mass, then gel mass is cut into the gel dressing with suitable thickness and size, processing procedure is cumbersome.
Summary of the invention
In order to overcome the shortcomings of that existing load medicine composite membrane controlled release is difficult, having the present invention provides one kind can be bloating tendency low close
Spend the long-acting controlled release composite membrane and its preparation method of net transmission slot.
The technical solution adopted by the present invention to solve the technical problems is: one kind has can bloating tendency low density web transmission slot
Long-acting controlled release composite membrane, including composite membrane main body and the microchannel transfer layer that composite membrane bottom part body is arranged in, composite membrane master
Body is divided into low-density from inside to outside and wears net supporting structure layer, gel state pressure transmission control layer and limitation film pressure transmission control
Preparative layer.
It according to another embodiment of the invention, further comprise that microchannel transfer layer bottom both ends are provided with aid in skin
Fixing layer.
According to another embodiment of the invention, further comprising uniformly can swelling inside gel state pressure transmission control layer
Pressure controls microgel.
It according to another embodiment of the invention, further comprise uniformly transmitting microchannel on the transfer layer of microchannel.
It according to another embodiment of the invention, further comprise that low-density wears uniformly distributed functive in net supporting structure layer.
According to another embodiment of the invention, further comprise following preparation step:
Step 1: limitation film surface modifies processing procedure: by limitation film surface that modification preparation is completed with can bloating tendency pressure control it is micro-
Gelinite is evenly dispersed to be fixed on the limitation film surface modified, first by can bloating tendency pressure control microgel water phase point
Scattered solution mixes slowly, and the time of stirring was at 6 hours or more, wherein limitation film surface system forms cationic surface layer through strong acid,
And can bloating tendency pressure control microgel surface then have anionic group, cationic density system penetrates strong acid treatment concentration
And the time controls, anionic group then through can bloating tendency pressure control microgel surface hydrolysis reach, can swelling
Property pressure control microgel pressure control range then regulated and controled using crosslink density, limitation film selects polyamine ester film, i.e., poly-
Amine ester limits film, and brushes through HCl gas, through hydrogen bond and Cloud Distribution, so that hydrochloric acid Molecular Adsorption is limited in Polyurethane
The amide group of film, and the surface of Polyurethane limitation film is made to form cation modification layer, such cation modification layer is significantly
Improve can bloating tendency pressure control microgel in the adsorption capacity and binding force of limitation film surface, and reached through charge rearrangement and being situated between
Electric potential relation, raising can bloating tendency pressure control microgel it is uniformly dispersed；
Step 2: the hydrophilic liquid processing procedure of microgel: be added in water can bloating tendency hydrogel, such as carbomer or the Asia of interlinkage type
Gram force hydrogel, and stir evenly to form that an aqueous dispersion liquid containing microgel is spare, and interlinkage type hydrogel, that is, microgel is true
It protects in water phase；
Step 3: microgel fluid viscosity is promoted and structure-reinforced processing procedure: make can bloating tendency pressure control microgel uniformly divide
It dissipates and is fixed on the limitation film surface modified, irradiate irradiation in processing procedure 1 ~ 15 minute after persistently carrying out UV ray, generation can be bloating tendency
Pressure controls microgel and interlinks with limitation the micro- of film surface, and the formation of micro- interlinkage is to provide junctional interfaces through UV ray irradiation
Strand diffusion motion reach；
Step 4: matrix low density web supporting structure system journey: polyvinyl alcohol and carboxymethyl cellulose are added in water, and mixes
After closing uniformly, because of physical interactive forces, it is spare that auxiliary forms uniform low density web supporting structure body pretreatment fluid；
Step 5: low density web supporting structure body immobilization processing procedure: being coated with the low density web supporting structure liquid solution of pre-coordination,
And stir evenly, complete preparation；
Step 6: microgel low density web bracket long-acting controlled release transport structures pressure controlling slots encapsulation: are set to a pressure
Between control layer and a microchannel transport layer, reach through multistage coating；
Step 7: the pressure controlling slots for being packaged with long-acting controlled release transport structures are overlying on substrate layer, can be furled after pasting
And cut, to be made there is long-acting controlled release to transmit medicated plaster.
The invention has the advantages that simplifying making step, and preparation efficiency is substantially improved, is suitble to factory's continuous and automatic
Manufacture, convenient for rapid, high volume production have various different-thickness plyability dressing；The dressing of production provide it is preferably ventilative,
Moisture-inhibiting, the intrusion of barrier bacterium and the characteristics such as control and absorption diffusate, so that wound is in good cell growth healing environment；
Since dressing is transparent, be conducive to directly observe wound healing situation, to control the treatment situation of wound.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is structural schematic diagram of the invention.
Fig. 2 is preparation flow chart of the invention.
Fig. 3 is the preparation flow chart of present invention limitation film pressure transmission control layer.
1. composite membrane main body in figure, 2. microchannel transfer layers, 3. low-density wear net supporting structure layer, and 4. gel state pressure pass
Defeated control layer, 5. limitation film pressure transmission control layers, 6. aid in skin fixing layers, 7. can swelling pressure control microgel, 8.
Transmit microchannel, 9. functives.
Specific embodiment
As shown in Figure 1, 2, it is a kind of with can bloating tendency low density web transmission slot long-acting controlled release composite membrane, including composite membrane
Main body 1 and the microchannel transfer layer 2 that 1 bottom of composite membrane main body is arranged in, composite membrane main body 1 are divided into low-density from inside to outside
Wear net supporting structure layer 3, gel state pressure transmission control layer 4 and limitation film pressure transmission control layer 5,2 bottom of microchannel transfer layer
Portion is provided with aid in skin fixing layer 6, inside gel state pressure transmission control layer 4 uniformly can swelling pressure control microgel 7,
Microchannel 8 is uniformly transmitted on microchannel transfer layer 2, low-density is worn uniformly distributed functive 9, functive 9 in net supporting structure layer 3 and divided
Cloth is in the intracorporal cell mass of film.
Its preparation method is the following steps are included: step 1: limitation film surface modifies processing procedure: the limitation film table that modification preparation is completed
Face with can the control of bloating tendency pressure microgel is evenly dispersed is fixed on the limitation film surface modified, bloating tendency can press first
The Aqueous dispersions solution of power control microgel mixes slowly at 35 DEG C, and the time of stirring was at 6 hours or more, it is therefore intended that makes
Can bloating tendency pressure control microgel can be fully dispersed and be irradiated through UV, the UV of 254nm, irradiation 30 preferably can be used
Minute, it is controllable can bloating tendency pressure control microgel it is bloating tendency.It limits film and selects polyamine ester film, is i.e. Polyurethane limits
Film, and brushed through HCl gas, through hydrogen bond and Cloud Distribution, so that hydrochloric acid Molecular Adsorption is in the acyl of Polyurethane limitation film
Amine groups, and the surface of Polyurethane limitation film is made to form cation modification layer, such cation modification layer greatly improves can be swollen
Lubricant nature pressure controls microgel in the adsorption capacity and binding force of limitation film surface, and closes through charge rearrangement and Jie up to current potential
System, raising can bloating tendency pressure control microgel it is uniformly dispersed.Can bloating tendency pressure control microgel system penetrate poly- first
Base acrylic chemistry sexual intercourse hammer is reached, and the ball that chemically interlinks has a plurality of negatively charged carbonic acid groups, through adjustment table
Face tension can make negatively charged carbonic acid group be distributed mainly on spherome surface, provide the sun formed with Polyurethane limitation film surface
Ion modification layer combines closely and improves bond strength, and different moles of carbonic acid group amount, which will affect, limits film surface with Polyurethane
Can bloating tendency pressure control microgel number, number will directly affect the pressure in limitation mould.In this way through limitation film table
Face modifies and regulates and controls bond strength, and carries out medicine controlled releasing through the sphere of releasable pressure.Can the control of bloating tendency pressure it is micro- solidifying
The ionic structure of colloid will affect associativity and pressure generates, and belong to crucial innovation controlling mechanism, and be easy to carry out industrialization design,
Generally in limitation film in addition to having no other modes from control through molecule transmitting and reciprocation, therefore importing in limitation film can
Regulate and control the unit of pressure, it is possible to provide the function of wisdom Drug controlled release belongs to innovative technology, can carry out microgel fluid viscosity and mention
It rises and structure-reinforced processing procedure；Step 2: the hydrophilic liquid processing procedure of microgel: in water be added can bloating tendency hydrogel, preferably make
With the carbomer or or mixtures thereof polymethacrylic acid hydrogel or polyacrylic acid hydrogel of interlinkage type.It is further preferred that using water
Gel mixture, wherein acrylic ratio is more than 10%.And it stirs and is formed uniformly an Aqueous dispersions containing microgel at 35 DEG C
Liquid is spare, and interlinkage type hydrogel, that is, microgel ensures in water phase；Step 3: microgel fluid viscosity promoted with it is structure-reinforced
Processing procedure: make can the control of bloating tendency pressure microgel is evenly dispersed is fixed on the limitation film surface modified, persistently carry out UV and penetrate
After line, irradiate processing procedure 1 ~ 15 minute and irradiate, basis of time can the bloating tendency control of bloating tendency pressure control microgel discharge ginseng
Number is related；Step 4: matrix low density web supporting structure system journey: being added polyvinyl alcohol and carboxymethyl cellulose in water,
And after mixing, because of physical interactive forces, it is spare that auxiliary forms uniform low density web supporting structure body pretreatment fluid；
Step 5: low density web supporting structure body immobilization processing procedure: it is coated with the low density web supporting structure liquid solution of pre-coordination, and is stirred
It mixes uniformly, completes preparation；Step 6: pressure controlling slots encapsulation: by microgel low density web bracket long-acting controlled release transport structures
It is set between a pressure control layer and a microchannel transport layer, reaches through multistage coating；Long-acting controlled release biography will be packaged with
The pressure controlling slots of defeated structural body are overlying on substrate layer, can be furled and be cut after pasting, and have long-acting controlled release transmission to be made
Medicated plaster.In known gel processing procedure, due to the meeting before carrying out polymerization reaction of the reaction mixture to form gel
Solution state is presented, therefore need to first be contained in progress polymerization reaction in container and be cut to form gel mass, then by gel mass
At the gel dressing with suitable thickness and size, however, in the present embodiment, via the promotion of microgel fluid viscosity and structure
Strengthening processing procedure makes reaction mixture be condensed into the lower high viscosity colloidal solution of mobility by the solution with high fluidity, such as
This one, can be directly with coating method in forming the colloid coating with required thickness on substrate, and colloid coating can Yu Jicai
Carry out cross-linking reaction, as irradiated processing procedure after UV ray, in this way, simplify have can bloating tendency pressure control microgel with it is low
The microgel low density web bracket long-acting controlled release transport structures fabrication steps of density net supporting structure body, and processing procedure is substantially improved
Efficiency is suitble to factory to manufacture in such a way that serialization is automatic, rapidly and in large quantities to produce answering with various different-thickness
The dressing of conjunction property；On the other hand, it is made have can bloating tendency pressure control microgel and low density web supporting structure body it
Microgel low density web bracket long-acting controlled release transport structures dressing provide preferably ventilative, moisture-inhibiting, the intrusion of barrier bacterium and
The characteristics such as control and absorption diffusate, so that wound is in good cell growth healing environment；Furthermore since dressing of the present invention is in
Transparence, therefore be conducive to directly observe wound healing situation, to control the treatment situation of wound.
Prepare the hydrophilic liquid processing procedure of microgel: by the carbomer of 30g, (German Merck company is manufactured, and product type is
Carbopol 941) it is dissolved in suitable water, and it is spare after mixing evenly, the average particle size distribution of the microgel is with 3 ~ 30 μ
M is preferable；Prepare functional covering liquid processing procedure: by the Arabic gum (Sigma Co., USA's manufacture) of 25g be dissolved in 100ml it
In distilled water, and it is placed on the containers for future use of 50 DEG C of water-bath, (is all then the U.S. by the methyl salicylate of 5g menthol, 5g
The manufacture of Sigma company) and the sorbitol ester (German Merck company manufacture) of 3g pour into together, water is added in the gelatin of 25g
In the distilled water of 60 DEG C of temperature, then water proof is heated and is stirred to dissolution, forms functional covering liquid；Prepare matrix low density web branch
Frame structural body processing procedure: by the polyvinyl alcohol (German Merck company manufactures) of 10g, and BRIJ35 neutrality interfacial agent 1 is added
Gram, Phospholipids is adjusted as the carboxymethyl cellulose of 1 gram of covering body structure regulator and 5g and 50ml water, and as structure
Agent dispersion with 5 grams of glycerol stir evenly, and be sufficiently mixed with 50ml functionality covering liquid, there is no special for the composition of the matrix
Limitation, as long as meeting functional component generates expected effect person, which includes: water, polyvinyl alcohol, ethylene contracting
Water D-sorbite stearic acid ester, carboxymethyl cellulose, and on a small quantity for example: menthol, methyl salicylate, tea tree ethereal oil etc. are easily waved
Volatile material, can also be added some Chinese medicines with effect when necessary, matrix made of the above composition allotment belong to it is aqueous, and
And made adjustments through glycerol, glycerol additive amount is no more than the 5% of total weight ratio.
Disperse existing matrix in the low density web bracket transport structures to generally comprise: water phase, oily phase, emulsifier with
Crosslinking agent, wherein emulsifier is selected from least one: lauryl sodium sulfate (auryl sodium sulfate), such as: poly-
Ethylene oxide Span-20, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitol acid anhydride list
Stearate, polyoxyethylene sorbitan tristearate anhydride, polyoxyethylene sorbitan monooleate, polyoxyethylene
Tween (Tween) class of sugar alcohol acid anhydride trioleate etc., such as: Span-20, sorbitan list palmitinic acid
Ester, sorbitan monostearate, sorbitan tristearate, sorbitan monooleate, sorbitan times
Sapn (Span) class, stearic acid and the oxygen sodium oxide molybdena or potassium hydroxide or hydrogen-oxygen of half oleate, sorbitan trioleate etc.
Change the monovalence soap that ammonium is formed；It is oily mutually selected from atoleine, silicone and phosphorus benzene bis-acid potassium isobutyl ester, phosphorus benzene bis-acid potassium diethylester,
Phosphorus benzene bis-acid potassium isopropyl ester, phosphorus benzene bis-acid potassium dibutyl ester, hexanedioic acid diethylester, sad diethylester, diethyl sebacate.Hydrophily
Substrate be made of hydrophilic tackness matrix, moisturizer, filler, water, wherein hydrophilic tackness matrix be selected from extremely
Few one kind: Sodium Polyacrylate, ammonium polyacrylate, polyacrylic acid monoethanol ammonium, polyacrylic acid diethanol ammonium, gathers polyacrylic acid potassium
Acrylic acid triethanol ammonium, sodium carboxymethylcellulose, carboxymethyl starch, tragcanth (Tragacanth), polyvinyl alcohol, poly- carboxylic second
Alkene, polyvinylpyrrolidone, polyacrylic acid, polyethylene glycol, Arabic gum, hydroxypropyl cellulose, hydroxyethyl cellulose, methylol
Cellulose, gelatin, agar (agar).Moisturizer is selected from least one: glycerol, mannitol, propylene glycol, sorbierite.Infiltration promotees
Ethyl alcohol, propylene glycol, aliphatic ester, dimethyl sulfoxide, oleic acid, linoleic acid, laruyl alcohol, azone, dodecyl sulphate are selected from into agent
Sodium, Tween 80 (polyoxyethylene sorbitan monooleate), urea, salicylic acid and N-Methyl pyrrolidone, N- ethyl pyrrole
Pyrrolidone, menthol, camphor, limonene and cineole (cajuputole).Lipophilic substrate is by lipophilic tackness base
Matter, filler composition, wherein lipophilic tackness matrix is to be selected from: rubber, natural rubber, rosin and resin etc..This is low close
Degree net bracket transport structures matrix can further be mixed with the functional cladding microcapsules for being coated with volatile component, volatile
Functional components content has volatile characteristic, specifically for example: menthol (menthol), methyl salicylate (methyl
Salicylate, scientific name are gaultherolin) and the plants such as sweet ginger, fennel ginger and cloves volatile oil, and functional cladding
Microcapsules are hardened by two kinds of different band charged colloids (such as: gelatin and Arabic gum) colloid and functional coats micro- glue
Capsule.
Test method: granularmetric analysis: laser particle instrument (Coulter Laser Particle Counter is used
LS230, USA), granularmetric analysis is carried out with the optical microscopy of band eyepiece micrometer；It is molten to be tested from rate: release paper is torn off into this hair
Bright composite membrane, then by composite membrane of the present invention be placed in it is molten from degree testing machine in carry out dissolving-separating test, this it is molten from degree testing machine in
It uses ethyl alcohol and water for eluat, and is tested with revolving speed 100rpm, the temperature of test is 25 DEG C and 37 DEG C two kinds, from progress
On-test, with 20 points, 30 points, 60 points, 90 points, 120 points, 150 points, 180 points, 210 points, 240 points, 270 points, 300 points, 330
Point, 360 points, the different times such as 390 points and 420 points be sampled, take out 5 milliliters every time, and detect with gas chromatograph & flame ion
It is molten from rate to survey device (Shimadzu GC-14A, Japan) measurement.
Described above to be merely exemplary for the purpose of the present invention, and not restrictive, those of ordinary skill in the art understand,
In the case where not departing from spirit and scope as defined in the appended claims, many modifications, variation or equivalent can be made, but all
It will fall within the scope of protection of the present invention.
Claims (6)
1. it is a kind of with can bloating tendency low density web transmission slot long-acting controlled release composite membrane, characterized in that including composite membrane main body
(1) and setting is in the microchannel transfer layer (2) of composite membrane main body (1) bottom, and composite membrane main body (1) is divided into low from inside to outside
Density wears net supporting structure layer (3), gel state pressure transmission control layer (4) and limitation film pressure transmission control layer (5).
2. it is according to claim 1 have can bloating tendency low density web transmission slot long-acting controlled release composite membrane, characterized in that
Microchannel transfer layer (2) bottom is provided with aid in skin fixing layer (6).
3. it is according to claim 1 have can bloating tendency low density web transmission slot long-acting controlled release composite membrane, characterized in that
The gel state pressure transmission control layer (4) is internal uniformly can swelling pressure control microgel (7).
4. it is according to claim 1 have can bloating tendency low density web transmission slot long-acting controlled release composite membrane, characterized in that
Microchannel (8) are uniformly transmitted on the microchannel transfer layer (2).
5. it is according to claim 1 have can bloating tendency low density web transmission slot long-acting controlled release composite membrane, characterized in that
The low-density wears functive (9) uniformly distributed in net supporting structure layer (3).
6. it is according to claim 1 have can bloating tendency low density web transmission slot long-acting controlled release composite membrane preparation method,
It is characterized in that, comprising the following steps:
Step 1: limitation film surface modifies processing procedure: by limitation film surface that modification preparation is completed with can bloating tendency pressure control it is micro-
Gelinite is evenly dispersed to be fixed on the limitation film surface modified, and closes through ionic bond junction, first can bloating tendency pressure
The Aqueous dispersions solution of control microgel mixes slowly, and the time of stirring was at 6 hours or more, wherein limitation film surface is to penetrate
Strong acid forms cationic surface layer, and can bloating tendency pressure control microgel surface then have anionic group, cationic is close
Degree is to penetrate strong acid treatment concentration and time to control, and anionic group then penetrates can bloating tendency pressure control microgel body surface
Face hydrolyzes to reach, can the pressure control range of bloating tendency pressure control microgel then regulated and controled using crosslink density；
Step 2: the hydrophilic liquid processing procedure of microgel: be added in water can bloating tendency hydrogel, such as carbomer or the Asia of interlinkage type
Gram force hydrogel, and stir evenly to form that an aqueous dispersion liquid containing microgel is spare, and interlinkage type hydrogel, that is, microgel is true
It protects in water phase；
Step 3: microgel fluid viscosity is promoted and structure-reinforced processing procedure: make can bloating tendency pressure control microgel uniformly divide
It dissipates and is fixed on the limitation film surface modified, irradiate irradiation in processing procedure 1 ~ 15 minute after persistently carrying out UV ray, generation can be bloating tendency
Pressure controls microgel and interlinks with limitation the micro- of film surface, and the formation of micro- interlinkage is to provide junctional interfaces through UV ray irradiation
Strand diffusion motion reach, can bloating tendency pressure control microgel there is the double bond that can interlink, irradiated through UV ray
Class provides strong interlinkage bond；
Step 4: matrix low density web supporting structure system journey: polyvinyl alcohol and carboxymethyl cellulose are added in water, and mixes
After closing uniformly, because of physical interactive forces, it is spare that auxiliary forms uniform low density web supporting structure body pretreatment fluid；
Step 5: low density web supporting structure body immobilization processing procedure: being coated with the low density web supporting structure liquid solution of pre-coordination,
And stir evenly, complete preparation；
Step 6: microgel low density web bracket long-acting controlled release transport structures pressure controlling slots encapsulation: are set to a pressure
Between control layer and a microchannel transport layer, reach through multistage coating；
Step 7: the pressure controlling slots for being packaged with long-acting controlled release transport structures are overlying on substrate layer, can be furled after pasting
And cut, to be made there is long-acting controlled release to transmit medicated plaster.
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