CN109512796A - Method for filling paracetamol capsules - Google Patents
Method for filling paracetamol capsules Download PDFInfo
- Publication number
- CN109512796A CN109512796A CN201811597065.3A CN201811597065A CN109512796A CN 109512796 A CN109512796 A CN 109512796A CN 201811597065 A CN201811597065 A CN 201811597065A CN 109512796 A CN109512796 A CN 109512796A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- oxycodone
- oxycodone hydrochloride
- paracetamol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 23
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 21
- 229960005489 paracetamol Drugs 0.000 title claims abstract description 18
- 238000011049 filling Methods 0.000 title abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 22
- BQNSLJQRJAJITR-UHFFFAOYSA-N 1,1,2-trichloro-1,2-difluoroethane Chemical compound FC(Cl)C(F)(Cl)Cl BQNSLJQRJAJITR-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960003617 oxycodone hydrochloride Drugs 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000007902 hard capsule Substances 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 238000007599 discharging Methods 0.000 claims abstract description 5
- 238000005303 weighing Methods 0.000 claims abstract description 4
- JLJIJKCIDZWTNY-PCHTVJFHSA-N C1=CC(OC)=C2C=3[C@@]45[C@@H](O2)C(=O)CC[C@@]4(O)[C@@H](CC13)N(C)CC5.C5(=CC=CC=C5)O.N Chemical compound C1=CC(OC)=C2C=3[C@@]45[C@@H](O2)C(=O)CC[C@@]4(O)[C@@H](CC13)N(C)CC5.C5(=CC=CC=C5)O.N JLJIJKCIDZWTNY-PCHTVJFHSA-N 0.000 claims description 11
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000005461 lubrication Methods 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 abstract description 6
- 239000008213 purified water Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract 2
- 238000005507 spraying Methods 0.000 abstract 2
- IKZDFQKVAYJUPL-RKXJKUSZSA-N C1=CC(OC)=C2C=3[C@@]45[C@@H](O2)C(=O)CC[C@@]4(O)[C@@H](CC13)N(C)CC5.NC5=C(C=CC=C5)O Chemical compound C1=CC(OC)=C2C=3[C@@]45[C@@H](O2)C(=O)CC[C@@]4(O)[C@@H](CC13)N(C)CC5.NC5=C(C=CC=C5)O IKZDFQKVAYJUPL-RKXJKUSZSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000011068 loading method Methods 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a method for filling an aminophenol oxycodone capsule, which comprises the steps of crushing a raw material acetaminophen medicament and screening the crushed raw material medicament through a screen; weighing 250-750 parts by weight of smashed and sieved acetaminophen, and adding the acetaminophen into a wet mixing granulator; weighing 2.5-7.5 parts of oxycodone hydrochloride, and adding 12.5-75 parts of purified water to completely dissolve the oxycodone hydrochloride; uniformly spraying an oxycodone hydrochloride aqueous solution into acetaminophen, adding 5-20 parts by weight of a flow aid and 25-75 parts by weight of a disintegrating agent into a wet mixing granulator, and fully and uniformly mixing the mixture with the materials and then discharging; drying; adding 5-20 mg of lubricant in parts by weight, and uniformly mixing; putting the obtained material into a full-automatic hard capsule filling machine to fill capsules. The problem of uneven mixing of oxycodone hydrochloride is solved by adding an appropriate amount of water to dissolve the oxycodone hydrochloride and spraying the oxycodone hydrochloride into other materials. The auxiliary materials used in the filling method can be uniformly mixed in the mixing process due to the characteristics of the materials.
Description
Technical field:
The invention belongs to technical field of medicine preparation, more particularly, to a kind of ammonia phenol oxycodone capsules fill method.
Background technique:
Ammonia phenol oxycodone capsules, indication be caused by a variety of causes, severe it is anxious, chronic ache.A small amount of systems
When standby, generally filled by hand using hard capsule dispenser.When mass production, semi-automatic or fully-automatic capsule filler is commonly used at present and is filled out
It fills.The capsule material of the above fill method production is uniform, content and weight aspect are less than normal without consistency, especially loading amount,
Loading amount shakiness phenomenon, not only influences production efficiency, also brings hidden danger to the product produced.
Summary of the invention:
The technical problems to be solved by the present invention are: provide it is a kind of can make the material of every capsule is uniform, content is consistent,
The consistent ammonia phenol oxycodone capsules fill method of weight.
In order to solve the above-mentioned technical problem, the present invention is achieved by the following technical solutions: a kind of ammonia phenol Oxycodone glue
Capsule fill method, includes the following steps,
S1, the sieve that paracetamol bulk pharmaceutical chemicals crushed to 20~80 mesh numbers；
S2, weigh in parts by weight 250~750 parts pulverize and sieve after paracetamol, be added wet-mixing
Granulator；
S3, the oxycodone hydrochloride for weighing 2.5~7.5 parts in parts by weight, and 12.5~75 parts are added in parts by weight
Purified water makes it completely dissolved；
S4, oxycodone hydrochloride aqueous solution is uniformly sprayed in paracetamol, then in parts by weight by 5~20 parts
Wet mixing pelletizer is added in glidant and 25~75 portions of disintegrating agents, discharging after being sufficiently mixed uniformly with above-mentioned material；
S5, it is then dried in micro-wave vacuum equipment；
S6, the sieve that material drying is crossed to 20~80 mesh numbers again, are then added the profit of 5~20mg in parts by weight
Lubrication prescription is uniformly mixed；
S7, resulting material is put into automatic hard capsule filler and fills capsule.
Preferably, the drying temperature in step S5 is 30 DEG C~60 DEG C.
Preferably, lubricant described in step S6 is magnesium stearate or talcum powder.
Preferably, the drying time in step S5 is 15~60min.
Compared with prior art, usefulness of the present invention is: since oxycodone hydrochloride dosage is smaller in prescription, tentatively
Test discovery directly mixes paracetamol and oxycodone hydrochloride, and since the two ratio differs greatly, oxycodone hydrochloride is difficult
To be uniformly mixed, uniformity of dosage units is caused to differ greatly, since oxycodone hydrochloride is soluble easily in water, so determining oxycodone hydrochloride
The method in unclassified stores is sprayed on after suitable water dissolution is added to solve the problems, such as that oxycodone hydrochloride mixing is non-uniform.Filling side
Auxiliary material used in method can be mixed uniformly in mixed process due to its substance self character.
Specific embodiment:
The present invention will be described in detail With reference to embodiment:
Embodiment one:
A kind of ammonia phenol oxycodone capsules fill method, includes the following steps, paracetamol bulk pharmaceutical chemicals crushed 30
The sieve of mesh number；Weigh in parts by weight 350mg parts pulverize and sieve after paracetamol, be added wet-mixing granulation
Machine；The oxycodone hydrochloride of 3.7mg is weighed in parts by weight, and the purified water that 24mg is added in parts by weight makes it completely dissolved；,
Oxycodone hydrochloride aqueous solution is uniformly sprayed in paracetamol, then in parts by weight by the glidant of 8mg and 45mg parts
Wet mixing pelletizer is added in disintegrating agent, discharging after being sufficiently mixed uniformly with above-mentioned material；Then in micro-wave vacuum equipment
In dried, drying time 28min, drying temperature be 42 DEG C；The sieve that material drying is crossed to 30 mesh numbers again, is then pressed
The lubricant of 10mg is added in parts by weight, and the lubricant is magnesium stearate, is then uniformly mixed；Resulting material is put into
Capsule is filled in automatic hard capsule filler.This method can make that the material of every capsule is uniform, content is consistent, weight one
It causes.
Embodiment two:
A kind of ammonia phenol oxycodone capsules fill method, includes the following steps, paracetamol bulk pharmaceutical chemicals crushed 30
The sieve of mesh number；Weigh in parts by weight 420mg parts pulverize and sieve after paracetamol, be added wet-mixing granulation
Machine；The oxycodone hydrochloride of 4.4mg is weighed in parts by weight, and the purified water that 28mg is added in parts by weight makes it completely dissolved；,
Oxycodone hydrochloride aqueous solution is uniformly sprayed in paracetamol, then in parts by weight by the glidant of 9mg and 54mg parts
Wet mixing pelletizer is added in disintegrating agent, discharging after being sufficiently mixed uniformly with above-mentioned material；Then in micro-wave vacuum equipment
In dried, drying time 35min, drying temperature be 45 DEG C；The sieve that material drying is crossed to 30 mesh numbers again, is then pressed
The lubricant of 15mg is added in parts by weight, and the lubricant is magnesium stearate, is then uniformly mixed；Resulting material is put into
Capsule is filled in automatic hard capsule filler.This method can make that the material of every capsule is uniform, content is consistent, weight one
It causes.
It is emphasized that: it is obvious to a person skilled in the art that the present invention is not limited to the above exemplary embodiments
Details can realize this in other specific forms and without departing from the spirit or essential characteristics of the present invention
Invention.Therefore, in all respects, the present embodiments are to be considered as illustrative and not restrictive, the present invention
Range be indicated by the appended claims rather than the foregoing description, it is intended that the meaning that the equivalent requirements of the claims will be fallen in
It is included within the present invention with all changes in range.
Claims (4)
1. a kind of ammonia phenol oxycodone capsules fill method, it is characterised in that: include the following steps,
S1, the sieve that paracetamol bulk pharmaceutical chemicals crushed to 20~80 mesh numbers；
S2, weigh in parts by weight 250~750 parts pulverize and sieve after paracetamol, be added wet-mixing granulation
Machine；
S3, the oxycodone hydrochloride for weighing 2.5~7.5 parts in parts by weight, and 12.5~75 parts of purifying is added in parts by weight
Water makes it completely dissolved；
S4, oxycodone hydrochloride aqueous solution is uniformly sprayed in paracetamol, then helps stream for 5~20 parts in parts by weight
Wet mixing pelletizer is added in agent and 25~75 portions of disintegrating agents, discharging after being sufficiently mixed uniformly with above-mentioned material；
S5, it is then dried in micro-wave vacuum equipment；
S6, the sieve that material drying is crossed to 20~80 mesh numbers again, are then added the lubrication of 5~20mg in parts by weight
Agent is uniformly mixed；
S7, resulting material is put into automatic hard capsule filler and fills capsule.
2. ammonia phenol oxycodone capsules fill method according to claim 1, it is characterised in that: the drying temperature in step S5
It is 30 DEG C~60 DEG C.
3. ammonia phenol oxycodone capsules fill method according to claim 1, it is characterised in that: lubrication described in step S6
Agent is magnesium stearate or talcum powder.
4. ammonia phenol oxycodone capsules fill method according to claim 1, it is characterised in that: the drying time in step S5
For 15~60min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811597065.3A CN109512796A (en) | 2018-12-26 | 2018-12-26 | Method for filling paracetamol capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811597065.3A CN109512796A (en) | 2018-12-26 | 2018-12-26 | Method for filling paracetamol capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109512796A true CN109512796A (en) | 2019-03-26 |
Family
ID=65796908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811597065.3A Pending CN109512796A (en) | 2018-12-26 | 2018-12-26 | Method for filling paracetamol capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109512796A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115656390A (en) * | 2022-12-08 | 2023-01-31 | 成都苑东生物制药股份有限公司 | Method for measuring content of paracetamol and oxycodone sustained release tablets |
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Application publication date: 20190326 |
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