CN1096694A - Tooth-strengthening chewing-gum and preparation method thereof - Google Patents
Tooth-strengthening chewing-gum and preparation method thereof Download PDFInfo
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- CN1096694A CN1096694A CN 93111461 CN93111461A CN1096694A CN 1096694 A CN1096694 A CN 1096694A CN 93111461 CN93111461 CN 93111461 CN 93111461 A CN93111461 A CN 93111461A CN 1096694 A CN1096694 A CN 1096694A
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- tooth
- chewing
- strengthening
- gum
- chinese medicine
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- 229940112822 chewing gum Drugs 0.000 title claims abstract description 13
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 13
- 238000005728 strengthening Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title description 4
- 239000003814 drug Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 13
- 210000000214 mouth Anatomy 0.000 claims abstract description 12
- 239000002671 adjuvant Substances 0.000 claims abstract description 10
- 229960000282 metronidazole Drugs 0.000 claims abstract description 9
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000003292 glue Substances 0.000 claims abstract description 7
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 4
- 241001046548 Anaerobium Species 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 241001504664 Crossocheilus latius Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 206010006326 Breath odour Diseases 0.000 abstract description 4
- 208000032139 Halitosis Diseases 0.000 abstract description 4
- 208000007565 gingivitis Diseases 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 3
- 208000002925 dental caries Diseases 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 208000025157 Oral disease Diseases 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 208000030194 mouth disease Diseases 0.000 abstract description 2
- 201000001245 periodontitis Diseases 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 235000001497 healthy food Nutrition 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000001055 chewing effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010061274 Malocclusion Diseases 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- -1 chlorhexidine salt Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000008242 dietary patterns Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Tooth-strengthening chewing-gum is to select that oral cavity anaerobium is had remarkable inhibiting Western medicine metronidazole or chlorhexidine salt and Chinese medicine Radix Zanthoxyli or Radix Zanthoxyli is active ingredient for use, adds the adjuvant of being made up of sugar, edible glue nurse etc. in right amount simultaneously, adopts certain method to be made.Clinic trial proof this product is obvious to alleviating oral inflammation, cleaning oral cavity, reduction dental plaque effect, especially residual root of teeth, missing tooth person, halitosis patient are acted on significantly, simultaneously dental caries also there is certain preventive and therapeutic effect, clinical prevention and the treatment that mainly is applicable to the oral disease (gingivitis, periodontitis, halitosis) of each stratum is a kind of popular novel healthy food at age.
Description
The invention provides a kind of tooth-strengthening chewing-gum and preparation method thereof.
Along with human living standard's raising, the softening of eating patterns, refine, acidification, people's masticatory function weakens day by day, jawbone, tooth
System degenerates day by day.And in this degenerative process, last mandibular bone, tooth are not that balanced synchronization is carried out, thereby produced the common dentognathic system of modern and carried out syndrome-malocclusion, gingivitis, periodontal disease, dental caries etc., become one of the highest disease of modern's sickness rate, especially with old man, children for very.For this class disease, still there is not ideal Drug therapy at present.At present the main method of tooth protection mostly is that the mechanicalness oral cavity is cleaned-brushed teeth, scaling, scrapes and control, transfer
Deng, these methods have tangible limitation, as brush teeth and hold time short and property at any time not, scaling, scrape method such as control at present can't be as a kind of general tooth protection method of socialization; Medicine tooth protection aspect, there once had periodontal health tablet, the peaceful solution of periodontal to be used for to be clinical, and the former is difficult to reach medicine concentration in the part, because of being the whole body administration, easily have side effects; The latter uses inconvenience.
The object of the invention is intended to tooth-strengthening chewing-gum that provides a kind of taking convenience at falling ill periodontal widely, popularizes easily and preparation method thereof, make people when chewing chewing gum, strengthen oral hygiene, the growth of dental plaque in the control oral cavity, particularly suppress anaerobe in intraoral breeding, thereby reach the purpose of cleaning oral cavity, alleviation oral inflammation and tooth protection, strong tooth.
Choosing side of the present invention medication takes into account 3 points: (1) is mainly anaerobic infection because of the infection in the oral cavity, thus selected that anaerobe is had unique inhibiting medicine, as metronidazole, chlorhexidine salt etc.; (2) the oral cavity dental caries is mainly due to the Streptococcus mutans, thus selected to have the Chinese medicine of unique anticaries action, as Radix Zanthoxyli, Cortex Magnoliae Officinalis, Flos Lonicerae etc.; (3) subjective symptoms behind the patient infection is exactly an inflammation pain, so selected the Chinese medicine of extensive use such as Radix Zanthoxyli etc., is used for analgesia.
Technical solution of the present invention is, with medicine for its active ingredient and be equipped with appropriate amount of auxiliary materials and be made, characteristic distributions according to anaerobe in the oral cavity, selected have remarkable inhibiting medicine to anaerobe, can be Western medicine such as metronidazole, chlorhexidine salt, also Chinese medicine such as Radix Zanthoxyli, people ground Taurus etc. are effective ingredient, are equipped with appropriate amount of auxiliary materials again, are made by certain method.According to the antibacterial onset concentration of medicine to anaerobe, simulation oral cavity drug release rate design drug dose, and by testing definite ratio range of the present invention repeatedly, in this ratio range, can guarantee saliva Chinese medicine concentration effectively (in Western medicine, greater than 2ug/ml), the side effect that can avoid the whole body administration to bring again (serve on 20 of this product, can not detect the existence of medicine in the blood), its ratio range is:
1～5 part of metronidazole or chlorhexidine salt (weight, down together)
1500～5000 parts of Radix Zanthoxyli or Radix Zanthoxyli
2500～4500 parts of adjuvants
Adjuvant of the present invention mainly plays a part to regulate product color and viscosity, and it basic composition is (weight %):
Sugar 68～78%
Edible glue nurse 22～32%
Flavorant 0～0.5%
Sugar can adopt sucrose or glucose, and the viewport sense needs to add an amount of glycerol and makes lubricant.
Manufacture method of the present invention is:
1, at first prepares the dense pure liquid (saturable) of Western medicine (metronidazole or chlorhexidine salt);
2, extract Chinese medicine (Radix Zanthoxyli or Radix Zanthoxyli) repeatedly to closely colourless with pure method, reclaim ethanol to rare extractum shape;
3, under heat-retaining condition, with the dense ethanol liquid of above-mentioned Western medicine, liquid glucose is a small amount of and the Chinese medicine extract stone roller closes;
4, adjuvant such as Icing Sugar, glue nurse and said mixture are ground even, extrusion molding, cooling, packing is product of the present invention.
Chinese medicine of the present invention except that Radix Zanthoxyli, Radix Zanthoxyli, also can adopt Cortex Magnoliae Officinalis, Flos Lonicerae etc.
The invention has the advantages that:
1, taking convenience.The popular food chewing gum of liking with people on the mouthfeel is as good as, and sweet fragrance is refrigerant tasty and refreshing, anti-chewing, and glad is popular acceptance.
2, curative effect is obvious.How tame this product is on probation through hospital clinical, and the total effective rate of prove its control periodontal disease, alleviating gingivitis is greater than 90%, and the total effective rate that reduces dental plaque index is greater than 94%.Compare with commercially available chewing gum and to have tangible cleaning oral cavity, eliminate the halitosis effect, clinical prevention and the treatment that mainly is applicable to the oral disease (gingivitis, periodontitis, halitosis) of each stratum at age.
3, medicine infiltrates in the glue nurse, can make oral cavity partial keep certain drug level by chewing slow release, guarantees lasting medicine.
4, the used dosage of medicine is little than oral dose, and it is big to play a role, and is safe and reliable.
Embodiment 1:
Prescription: 1 part of metronidazole, 1500 parts of Radix Zanthoxylis, 2500 parts of adjuvants.
Method for making: get 95% ethanol percolation Radix Zanthoxyli to closely colourless.Get 95% dissolve with ethanol metronidazole and become saturated solution.
To go up two liquid and mix, fling to most ethanol, and add a little liquid glucose (so that solution thickness be degree) slightly and fully grind even.
The thick liquid that above-mentioned stone roller is even, edible glue nurse, Icing Sugar fully grind in fireless cooker and close (the softening material of pot Wen Yineng is degree), add the flavorant extrusion molding, cooling, packing, and product meets food hygienic standard after testing.
Embodiment 2:
Prescription: 5 parts of metronidazoles, 5000 parts of Radix Zanthoxyli, 4500 parts of adjuvants, method for making is the same.
Claims (5)
1, a kind of sugar that comprises, the tooth-strengthening chewing-gum that adjuvants such as glue nurse are formed is characterized in that it comprises that also oral cavity anaerobium is had remarkable inhibiting Western medicine metronidazole or chlorhexidine salt and Chinese medicine Radix Zanthoxyli or people ground Taurus, it consists of (weight portion):
1～5 part of metronidazole or chlorhexidine salt
1500～5000 parts of Radix Zanthoxyli or people ground Taurus
2500～4500 parts of adjuvants
2, tooth-strengthening chewing-gum according to claim 1 is characterized in that used Chinese medicine is Cortex Magnoliae Officinalis, Flos Lonicerae.
3, key tooth chewing gum according to claim 1 and 2 is characterized in that adjuvant consists of (weight %)
Sugar 68～78% edible glue nurses 22～32%
Flavorant 0～0.5%
4, tooth-strengthening chewing-gum according to claim 3 is characterized in that the viewport sense need add an amount of glycerol.
5, a kind of manufacture method of tooth-strengthening chewing-gum is characterized in that:
(1), at first prepares the dense pure liquid of Western medicine;
(2), extract Chinese medicine repeatedly to closely colourless, reclaim ethanol to rare extractum shape with pure method;
(3), under heat-retaining condition, with the dense ethanol liquid of above-mentioned Western medicine, liquid glucose is a small amount of and the Chinese medicine extract stone roller closes;
(4), adjuvant and said mixture are ground even, extrusion molding, cooling, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93111461 CN1096694A (en) | 1993-06-23 | 1993-06-23 | Tooth-strengthening chewing-gum and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93111461 CN1096694A (en) | 1993-06-23 | 1993-06-23 | Tooth-strengthening chewing-gum and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1096694A true CN1096694A (en) | 1994-12-28 |
Family
ID=4989244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93111461 Pending CN1096694A (en) | 1993-06-23 | 1993-06-23 | Tooth-strengthening chewing-gum and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1096694A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7470442B2 (en) | 2005-12-02 | 2008-12-30 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| CN103583781A (en) * | 2013-11-01 | 2014-02-19 | 阳波 | Coffee-flavored metronidazole chewing gum |
| CN104918497A (en) * | 2012-10-26 | 2015-09-16 | 罗盖特兄弟公司 | Microalgal flour granules and process for preparation thereof |
| CN107149028A (en) * | 2017-04-17 | 2017-09-12 | 廖华勇 | Include the gum of micro tobacco flavor |
| CN109329587A (en) * | 2018-12-26 | 2019-02-15 | 湖北中博绿亚生物技术有限公司 | The food additives and preparation method thereof that dog cat eliminates bad breath |
| CN111557369A (en) * | 2020-05-29 | 2020-08-21 | 中南林业科技大学 | A kind of chewing gum for rapidly inhibiting Fusobacterium nucleatum and preparation method thereof |
-
1993
- 1993-06-23 CN CN 93111461 patent/CN1096694A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7592025B2 (en) | 2005-12-02 | 2009-09-22 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
| US7544377B2 (en) | 2005-12-02 | 2009-06-09 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
| US7470442B2 (en) | 2005-12-02 | 2008-12-30 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
| CN104918497A (en) * | 2012-10-26 | 2015-09-16 | 罗盖特兄弟公司 | Microalgal flour granules and process for preparation thereof |
| CN103583781A (en) * | 2013-11-01 | 2014-02-19 | 阳波 | Coffee-flavored metronidazole chewing gum |
| CN103583781B (en) * | 2013-11-01 | 2015-11-25 | 阳波 | Caf metronidazole chewing gum |
| CN107149028A (en) * | 2017-04-17 | 2017-09-12 | 廖华勇 | Include the gum of micro tobacco flavor |
| CN109329587A (en) * | 2018-12-26 | 2019-02-15 | 湖北中博绿亚生物技术有限公司 | The food additives and preparation method thereof that dog cat eliminates bad breath |
| CN111557369A (en) * | 2020-05-29 | 2020-08-21 | 中南林业科技大学 | A kind of chewing gum for rapidly inhibiting Fusobacterium nucleatum and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |