CN109793496A - A device and application for measuring intraocular pressure combining sensor and SS-OCT technology - Google Patents
A device and application for measuring intraocular pressure combining sensor and SS-OCT technology Download PDFInfo
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- 230000004410 intraocular pressure Effects 0.000 title claims abstract description 36
- 238000005516 engineering process Methods 0.000 title claims description 8
- 210000004087 cornea Anatomy 0.000 claims abstract description 35
- 238000012014 optical coherence tomography Methods 0.000 claims abstract description 34
- 238000012360 testing method Methods 0.000 claims abstract description 34
- 210000005252 bulbus oculi Anatomy 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 2
- 238000011088 calibration curve Methods 0.000 claims description 2
- 229920006268 silicone film Polymers 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 abstract description 7
- 238000007796 conventional method Methods 0.000 abstract description 4
- 238000001514 detection method Methods 0.000 abstract description 4
- 239000003990 capacitor Substances 0.000 description 9
- 230000006872 improvement Effects 0.000 description 8
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
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- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
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- 238000012937 correction Methods 0.000 description 1
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Abstract
The invention discloses the device of a kind of combination sensor and SS-OCT technical testing intraocular pressure, the device includes sensor, optical coherence tomography devices and linear stage；The sensor is right against the top placement of test eyeball, and the test eyeball is placed in linear stage, and the linear stage drives test eyeball to be moved forward and backward, and adjusts the distance between sensor；The optical coherence tomography devices include scanning lens, when test, are adjusted on cornea to be measured to the focal length of scanning lens.Device designed by the present invention not only realizes lossless detection high intraocular pressure, and used sensor has very high sensitivity, it is able to detect cornea of the sening as an envoy to small power that deformation occurs compared to conventional method and obtains accurate cornea applanation area, it is more accurate compared to conventional method.
Description
Technical field
The invention belongs to medical image detection fields, and in particular to a kind of combination sensor and OCT technology test intraocular pressure
Device and application.
Background technique
High intraocular pressure (IOP) has proven to lead to one of Major Risk Factors of glaucoma.Treatment intraocular hypertension and
When especially receiving the patient of ophthalmologic operation, it is critically important to obtain accurate IOP for glaucoma patient.Currently, most reliable and extensive
The IOP measurement method of receiving is the applanation tonometry (GAT) that Goldmann is proposed.The basic principle of GAT depends on
Imbert-Fick law, wherein the power on flat cornea surface is equal to the true IOP(IOPT of anterior corneal surface) and flattening area
Product.Optical coherence tomography (OCT) be early development the 1990s one kind in real time, quickly, it is high-resolution, non-
Invasive new bio medical imaging technology.It is widely used in obtaining Noninvasive Real time Organization pathological image (example
Such as retina image-forming), spatial resolution is 1-15 μm, without radiation injury.OCT is in many basic research and clinical application
In played important function.It is phase-resolved that a kind of new dual-beam proposed by using frequency sweep OCT(SS-OCT) in the present invention
Doppler OCT systems and a kind of new method for obtaining exact image information.
Tonometry method based on GAT needs delicately to detect cornea of the sening as an envoy to small power that deformation occurs and obtains essence
True cornea applanation area, but so far, there are no in tonometry is tested while the method that solves both demands
Relevant report.
Summary of the invention
In view of the above-mentioned problems, the present invention proposes the device of a kind of combination sensor and SS-OCT technical testing intraocular pressure and answers
With.
It realizes above-mentioned technical purpose, reaches above-mentioned technical effect, the invention is realized by the following technical scheme:
A kind of device of combination sensor and SS-OCT technical testing intraocular pressure, the device include that sensor, optical coherence are disconnected
Layer scanning device and linear stage；The sensor is right against the top placement of test eyeball, and the test eyeball is placed
In linear stage, the linear stage drives test eyeball to be moved forward and backward, and adjusts the distance between sensor；Described
Optical coherence tomography devices include scanning lens, when test, are adjusted on cornea to be measured to the focal length of scanning lens.
As a further improvement of the present invention, the sensor is condenser type flexibility force snesor, including is set to top
With the electrode layer of bottom and be located in the middle compliance cavity room floor, the compliance cavity room floor is by using the side for being bonded in electrode layer
The area of space that the double faced adhesive tape of edge surrounds instills the ion that volume is less than chamber volume in the center of the compliance cavity room floor
Drop, under the action of external load, drop changes the size of sensor capacitance by changing with the contact area of electrode layer.
As a further improvement of the present invention, the sensor is also connected with impedance analyzer.
Using the method for the device to test intraocular pressure that the present invention is built, comprising the following steps:
Required power F when being driven plain using sensor measurement cornea；
SS-OCT device measuring applanation area S is used while cornea is driven plain；
Calculate IOP value, the i.e. ratio of F and S.
As a further improvement of the present invention, when measurement, the primary data that the sensor obtains is capacitance, later
Required power F when cornea is driven plain is obtained according to the linear relationship between the changing value of capacitor and the power for acting on sensor.
As a further improvement of the present invention, applanation area S obtained is the area after calibration, will by calibration curve
Practical contact area A obtained is calibrated.
As a further improvement of the present invention, what the SS-OCT equipment acquired is the contact between cornea and sensor
Image, the image obtain contact area A by the method that data are fitted.
It as a further improvement of the present invention, further include opaque in one layer of anterior corneal surface placement when acquiring contact image
Silica gel film layer.
Beneficial effects of the present invention: the present invention obtains being applied on cornea using the flexible force snesor based on drop
Power obtains contact area when cornea is flattened by sensor between sensor and cornea by SS-OCT, not only realizes lossless
Detection high intraocular pressure, and used sensor have very high sensitivity, be able to detect and send as an envoy to compared to conventional method
The cornea small power that deformation occurs and the accurate cornea applanation area of acquisition, it is more accurate compared to conventional method.
Detailed description of the invention
A kind of structural schematic diagram of embodiment of sensor that Fig. 1 is built for the present invention；
Fig. 2 is the SS-OCT device structure schematic diagram built；
Fig. 3 is intraocular pressure schematic structural diagram of testing device of the invention；
Fig. 4 is the sensitivity of sensor used in the measured present invention；
Fig. 5 is the relational graph in the sensor of invention between moving distance and capacitance variations；
Fig. 6 is the two-dimensional transversal scan image (B-scans) when SS-OCT equipment sensor obtained flattens cornea；
Fig. 7 (a) is the relational graph before corrected between moving distance and contact area, and Fig. 7 (b) is moving distance after amendment and flattens
Relational graph between area；
Relational graph of the Fig. 8 between the actually detected intraocular pressure IOP arrived and true intraocular pressure IOPT.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
A specific embodiment of the invention is described in further detail below.
(1) sensor manufactures
Sensor in the present invention is by up of three-layer: positioned at top and bottom electrode layer and be located in the middle compliance cavity room floor,
The electrode layer is made of transparent substrates and transparent electrode coating, and the compliance cavity room floor is by being arranged at conductive layer edge
Double faced adhesive tape be made into upper layer and lower layer electrode layer.The thickness of transparent substrates used in the present invention and transparent electrode coating
Respectively 125 μm and 100nm, electrode layer have high optical transparency (at visible wavelengths transmission coefficient be 80.9%) and
High conductivity (50 Ω-1).Used double faced adhesive tape (3M 468MP) with a thickness of 125 μm.
The manufacturing flow chart of the sensor as shown in Figure 1.In the first step, we use graphic design software
The design of (CorelDRAW X6) and laser-induced thermal etching instrument (VLS 2.30) and etched electrodes layer and double faced adhesive tape, double faced adhesive tape are designed as
Not closed annular, to provide the ventilation of Sensing chamber.Double faced adhesive tape is first aligned and pastes bottom electrode to form sensing chamber
Room.The ion drop that volume is 0.1 μ L is dripped by micropipette in the center of compliance cavity room floor later.Then by top electricity
Pole is aligned and pastes on double faced adhesive tape.Finally, connecting the line on corresponding electrode.Wherein dripped in compliance cavity room floor
The volume of the ion drop added is less than the volume of chamber from far away, and when effect of the sensor by power, drop occurs geometry and becomes
Shape can become larger in the contact area in Sensing chamber between solid-liquid, to change the capacitor of sensor.Therefore it can pass through biography
Sensor capacitor detected extrapolates the size for acting on sensor force.
(2) SS-OCT equipment is built
The SS-OCT equipment built in the present invention as shown in Figure 2 is mainly by swept light source (SSOCT-1050, Axsun
Technologies), reference arm and sample arm, and by dual balanced detection device (PDB471C, Thorlabs Inc.) and modulus
The data collection system of converter (ATS9351, Alazartech) composition.When being tested in the present invention, in used light source
Cardiac wave a length of 1060nm, bandwidth 110nm, obtain image with the sample frequency of 100 kHz in real time.Data collection system is established
In LabVIEW platform (National Instruments, TX, USA), for capturing image data.Finally, with MATLAB come
Image data is handled to obtain contact area (A).
The reference arm and sample arm includes multiple lens, collimator and the plane microscope group for changing the light direction of propagation
At wherein the lens in sample arm include the scanning lens for observing cornea.Eyeball is placed under scanning lens when test,
So that cornea is in the focal position of the lens in sample arm, observe OCT image display interface, the position of fine tuning pig eye make be in
The cornea image of existing complete display.
(3) intraocular pressure test device
Entire measuring system (Fig. 2) is divided into five parts: test eyeball, SS-OCT equipment, sensor, linear stage (LMS,
LTS300/M, Thorlabs Inc.) and dynamometer (M5-05, Mark-10).Wherein, the dynamometer and sensor phase
Even, the reliability for verificating sensor data obtained.The sensor is right against the top placement of test eyeball, institute
The test eyeball stated is placed in linear stage and is fixed using ring is inhaled, and the linear stage drives before and after test eyeball
It is mobile, adjust the distance between sensor.Physiological saline is injected into eyeball using the syringe with syringe needle when test, utilizes three
Lead to the IOPT for connecing syringe, pressure gage and syringe pump to monitor pig intraocular part.It is connect to focus light at sensor-cornea
It touches on interface without additionally adjusting, the present invention is using fixed sensor while in such a way that LMS controls test eyeball
Position is adjusted, when apexes contact of the sensor just with cornea, we are defined as initial contact location.In the control of LMS control
Under system, eyeball is mobile to sensor surface, and the resolution ratio of LMS is 1 μm, and mobile distance definition is moving distance (D).Each
Contact position is recorded the capacitor (C) of force snesor by impedance analyzer (WK 65120B), is applied to by dynamometer measurement
Power (F) on cornea, and the contact area on anterior corneal surface is observed by SS-OCT equipment, it is fitted and is calculated by data by MATLAB
Method is post-processed.It should be noted that we are soft in one layer of anterior corneal surface placement in order to enhance the intensity of cornea image signal
Soft opaque silicon glue film, used opaque silicon glue film with a thickness of 50 μm, be by graphite and silica gel (Ecoflex-
0030) it mixes, the graphite accounts for the 1.9% of total weight.
Analysis of experimental results:
(1) sensitivity of sensor
The sensitivity definition of sensor is S=δ (△ C/C0)/δ F, wherein C0It is capacitor when not applying pressure, △ C is electricity
The opposite variation held, F are consequently exerted at epibulbar power.We by change pig eye true intraocular pressure (IOPT) come study power and
Relationship between relative capacity variation.As shown in Figure 4.Act between the power of sensor and capacitance variations that there are highly linear passes
System.When moving distance is fixed, IOPT is bigger, keeps the cornea required power that flattens bigger, and the variation of capacitor is bigger.We compare
Compared with the sensitivity under three kinds of moving distances 0.2mm, 0.4mm and 0.6mm.In small power range 0N to 0.09N, our biography
Sensor sensitivity is 0.26 N-1。
(2) relationship between moving distance and capacitance variations
As shown in figure 5, with the increase of IOPT, the variation of capacitor increases under fixed moving distance.On the other hand, when
When IOPT is fixed, with the increase of moving distance, bigger power is needed to flatten cornea.Under the intraocular pressure of 25mmHg, work as cornea
When being depressed into 0.6mm, the variation of capacitor reaches maximum value (△ C/C0=0.0192).By these curves, it can be observed that I
Sensor can delicately detect 3mmHg IOPT variation.
(3) relationship between stroke distances and flat site
We have also investigated the relationships between moving distance during cornea applanation (D) and applanation area (S).By constant
The moving distance of IOPT, sensor are controlled by linear moving table, and can be seen by the image obtained by SS-OCT equipment
Observe the contact area (A) between cornea and sensor.Fig. 6 give when IOPT be 16mmHg when, moving distance be 0.2mm and
When 0.6mm, the contact image of sensor and cornea.What the coordinate by being fitted the contact portion of 15 B-scans was fitted
It is oval.
Fig. 7 (a) compares the relationship under each IOPT between contact area and moving distance (A-D curve).As can be seen that
A-D curve is highly linear, and is influenced by IOPT small.
But in the present invention, the part in our system for contacting cornea is soft and flexible.Therefore, from
The contact area that SS-OCT image obtains is likely larger than actual applanation area.Here calibration factor is applied to A-D song by us
Line.According to goldstandard, if IOP is 19mmHg, power needed for flattening 7.35mm2 is 0.0186N.In our measurement result
In, when power is 0.0185N, contact area is 14.81 mm2.Therefore, use 14.81/7.35 ≈ 2 as calibration factor, obtain
The relationship between moving displacement and applanation area is obtained, as shown in Figure 7 (b).
(4) IOP measured
According to previous analysis, the IOP for testing measurement can be by corresponding to the power of capacitor output divided by the applanation area of correction
To calculate.Fig. 5 compares the relationship of IOPT and the experiment IOP of measurement at the moving distance of 0.2mm, 0.4mm and 0.6mm.
As shown, IOPT shows similar trend with the relationship of the IOP of experiment measurement, and has when moving distance is 0.2mm
There is about 1 slope.This shows when moving distance is controlled within the scope of this, is surveyed using our sensor and SS-OCT
The IOP measured can reflect IOPT.When moving distance is 0.2mm, the average deviation of the IOP and IOPT that measure are 2%.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (8)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773335A (en) * | 2021-02-07 | 2021-05-11 | 苏州大学 | Sensor, imaging system and imaging method applied to optical coherent elastography |
| CN113827182A (en) * | 2021-09-26 | 2021-12-24 | 苏州大学 | Eyelid contact type intraocular pressure measuring device and measuring method thereof |
| CN113867006A (en) * | 2021-09-28 | 2021-12-31 | 电子科技大学 | A flexible multifunctional contact lens based on γ-Fe2O3@NiO magnetic oxide nanosheets |
| CN119375036A (en) * | 2024-12-26 | 2025-01-28 | 北京航空航天大学 | A biomechanical performance testing system for eyeball wall tissue |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112773335A (en) * | 2021-02-07 | 2021-05-11 | 苏州大学 | Sensor, imaging system and imaging method applied to optical coherent elastography |
| CN112773335B (en) * | 2021-02-07 | 2021-12-28 | 苏州大学 | Sensor, imaging system and imaging method applied to optical coherence elastography |
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| CN113867006A (en) * | 2021-09-28 | 2021-12-31 | 电子科技大学 | A flexible multifunctional contact lens based on γ-Fe2O3@NiO magnetic oxide nanosheets |
| CN119375036A (en) * | 2024-12-26 | 2025-01-28 | 北京航空航天大学 | A biomechanical performance testing system for eyeball wall tissue |
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