CN100341477C - Film patch for shading sun and treating eye wrinkles - Google Patents

Abstract

The invention relates to a film for sun protection and treatment of eye wrinkles, which comprises: a backing layer for loading active components; a gel layer laid on the top of the backing layer; a gel layer covering the gel layer Anti-stick layer. The invention discloses a film for sun protection and treatment of eye wrinkles, which has the advantages of researching and inventing the eye film according to the physiological and pharmacological characteristics of the skin, acting on the skin in sequence, and opening the skin channel. Composed of drugs for skin barrier regulation and skin conditioning drugs to achieve the purpose of transdermal absorption, the effect of treating skin texture and wrinkles is remarkable. Because the skin around the eyes is delicate and sensitive, it is the main prone area of aging. This eye mask can play the role of decoration and sun protection.

Description

A film for sun protection and treatment of eye wrinkles

technical field

The invention relates to the field of medical cosmetology, in particular to a film for sun protection and treatment of eye wrinkles.

Background technique

According to a recent survey report on the skin condition of Asian women, nearly 50% of them are worried about the primary problem of their skin condition, which is "wrinkles". The skin around the eyes is the weakest in the human body. Because the distribution of sweat glands and sebum is less, the skin around the eyes is drier, so it is also the most prone to wrinkles. Eye wrinkles are divided into three types from shallow to deep: dry lines caused by lack of water in the stratum corneum; linear lines (commonly called crow's feet) caused by acanthine cell atrophy caused by lack of water in the stratum corneum; deep wrinkles. There are currently many methods for treating eye wrinkles. These treatments generally use water supplementation and Chinese medicine conditioning as the treatment principle. Due to skin barrier problems, Chinese medicine ingredients are difficult to absorb, and the curative effect is limited; the current mask technology has not considered and failed. Solve the problem of effective absorption of pharmaceutical ingredients. The treatment is not very targeted. At present, the whole face sheet mask is used as the design. The treatment mainly focuses on the treatment of pigmentation and other treatments, and there is no targeted treatment for specific parts such as wrinkles.

Contents of the invention

The object of the present invention is to provide a film for sun protection and treatment of eye wrinkles.

The purpose of the present invention is achieved by the following technical methods:

A sunscreen, eye wrinkle treatment patch comprising:

a backing layer for loading active components;

a gel layer applied on top of the backing layer;

A release layer covering the gel layer.

The gel layer contains polyvinyl alcohol PVA-124, silica gel, hyaluronic acid and water. The components contained in the gel layer are by weight percentage:

Polyvinyl alcohol PVA-124 10-20%

Hyaluronic Acid 20-30%

Silicone 15-25%

Water balance.

The backing layer is aluminum-containing polyethylene composite film.

The said backing layer is coated with individualized color pictures with three-dimensional figure decorations.

The anti-adhesive layer mentioned is a polyester film whose surface is treated with anti-adhesive silicone oil.

The film for sun protection and treatment of eye wrinkles includes a backing layer for loading active components, laid on the top of the backing layer, a gel layer containing polyvinyl alcohol PVA-124, silica gel, hyaluronic acid, water, covering Release layer made of silicone-treated polyester on top of the gel layer, removed before use.

(1) a preparation method of a diaphragm for sun protection and treatment of eye wrinkles, comprising the following steps:

(1) Glue making: take polyvinyl alcohol PVA-124 as the gel matrix to make a glue, add silica gel and hyaluronic acid, mix, and get a gel after cooling;

(2) Coating: the above-mentioned gel is evenly coated on the silicone-treated polyester release layer, and fully dried;

(3) Compression sealing: cover the backing film, seal it, and punch it into a suitable size to obtain a film for sun protection and eye wrinkles treatment.

(2) a preparation method of a diaphragm for sun protection and treatment of eye wrinkles, comprising the following steps:

(1) Glue making: take polyvinyl alcohol PVA-124 as the gel matrix to make a glue, add silica gel and hyaluronic acid, mix, and get a gel after cooling;

(2) Coating: the above-mentioned gel is evenly coated on the silicone-treated polyester release layer, and fully dried;

(3) Compression sealing: cover the backing film, the backing film is coated with personalized color pictures, with three-dimensional decorations, seal, punch and cut into a suitable size, that is, a diaphragm for sun protection and eye wrinkles treatment.

Animal experiment of the present invention

1. Experimental animals: 15kg Duroc yellow-coated piglets, fed with common feed and kept indoors out of direct sunlight.

2. Therapeutic drug: use polyvinyl alcohol PVA-124 to make gel matrix, drug: hyaluronic acid.

3. Treatment method: select the skin of the eyelid of the pig as the experimental area, and divide it into two groups, (1) the control group applies polyvinyl alcohol PVA-124 to make a gel. (2) Sunscreen containing polyvinyl alcohol PVA-124, silica gel, hyaluronic acid, film for treating eye wrinkles.

4. Detection method: Two weeks, one month, two months and three months after the sticking treatment, the skin appearance was observed, and biopsy specimens were taken, fixed in formalin, embedded in paraffin, sectioned, and stained with HE. Histological observation and statistical analysis: After HE staining, the changes of piglet skin epidermal cells and papillary dermis collagen tissue were observed under light microscope. The piglet normal skin group was used as the control group, image analysis was performed on slices of different periods in each group, the thickness of the epidermis was measured, and analysis of variance was used for analysis and comparison.

5. Results:

1. Morphological observation of skin tissue

In the treatment group, the collagen tissue in the papillary dermis layer was thickened to varying degrees, and some obvious collagen strips appeared, namely the so-called Grenz zone.

Table 1 Morphological changes of skin tissue after sticking treatment drug epidermis papillary dermis time cell arrangement Tightness Collagen fibers therapy group two weeks ± - ± January + ++ + two months + ++ + March + ++ ++ two weeks + - ± control group January - ± - two months - - - March - - ±

Note: - not obvious, irregular or disordered; + neat, tight, clear, obvious

2. Epidermis thickness measurement

The skin epidermis of the treatment group all thickened in one month, and tended to be stable in two months. The thickness of the epidermis of the three-month skin is significantly different from that of the normal skin, and the result of variance analysis shows that P<0.05.

Table 2 Measurement of epidermal layer thickness after skin treatment (unit: μm) 2 weeks after treatment 1 month after treatment February after treatment 3 months after treatment therapy group 58.1490 63.5767 69.8896 74,9768 control group 55.9344 56.0481 55.7666 55.7932

Table 3 Measurement of collagen layer thickness after skin treatment (unit: μm) 1 week after treatment 1 month after treatment February after treatment 3 months after treatment therapy group 11.987 15.981 18.629 21.523 control group 9.3211 9.2444 9.2956 9.4112

6. Description

1. The arrangement of epidermal cells directly affects the appearance and texture of the skin, the arrangement is neat, and the skin appears smooth and delicate. At the same time, the tightness of the cells is related to the moisturizing ability of the skin. The tight arrangement can effectively prevent the loss and evaporation of water in the skin and keep the skin smooth and elastic. The observation of epidermal cells in each treatment group found that by January and February, the cell arrangement was ideal, with good skin appearance and texture.

2. The proliferation and rearrangement of collagen fibers can increase the matrix in the dermis, improve the quality of elastic fibers, improve fine wrinkles, and dilute deep wrinkles, increasing the elasticity and luster of the skin. Observation of the collagen tissue in the treatment group revealed that there were collagen strips in the papillary dermis or thickening of the collagen tissue to varying degrees.

3. The thickness of the epidermis has a direct impact on the quality of the skin. If the epidermis is too thick, the skin will appear dull and dull. If the epidermis is too thin, the skin sensitivity will increase and allergies will easily occur. An appropriate thickness of the epidermis is a key factor for the skin to maintain its optimal condition. According to the measurement of the thickness of the epidermis, it was found that the thickness of the epidermis increased significantly at two months after the treatment.

Clinical research of the present invention

Clinical treatment grouping: outpatients with eye wrinkles were randomly divided into two groups. Group 1, sunscreen containing polyvinyl alcohol PVA-124, silica gel, hyaluronic acid, film for treating eye wrinkles; control group, polyvinyl alcohol + silica gel composite.

Clinical treatment methods: 1. According to the doctor's advice, apply to the wrinkles around the eyes for about 12 hours a day. Those with dermatitis, rash and allergies were removed from the experimental group. make another observation;

2 During the follow-up visit in two weeks, one month, two months and three months of treatment, fill in the curative effect observation form, including the doctor's objective examination and the patient's subjective curative effect form, and comprehensively count the curative effect.

Results: A total of 3 patients with rash and allergies were selected, and the curative effect statistics are as follows: as shown in Table 4

Table 4: Efficacy Statistics* observation time curative effect grade group 1 control group Evaluation (example) curative effect rate (%) evaluation (example) Curative rate (%) 2 weeks efficient Wrinkles are visibly improved 9 28.75% 0 2.5% Partial improvement of wrinkles 14 2 invalid wrinkle no change 57 71.25% 78 97.50% 1 month efficient Wrinkles are visibly improved 10 38.75% 0 1.25% Partial improvement of wrinkles twenty one 1 invalid wrinkle no change 45 61.25% 79 98.75% 2 months efficient Wrinkles are visibly improved twenty two 63.75% 0 1.25% Partial improvement of wrinkles 29 1 invalid wrinkle no change 29 36.25% 79 98.75% 3 months efficient Wrinkles are visibly improved 25 81.25% 0 1.25% Partial improvement of wrinkles 40 1 invalid wrinkle no change 15 18.75% 79 98.75% Total number of observers (example) N=80 N=80

* Statistical analysis: X ² test, treatment group and control group, P value <0.01

The invention discloses a film for sun protection and treatment of eye wrinkles, which has the advantages of researching and inventing the eye film according to the physiological and pharmacological characteristics of the skin, acting on the skin in sequence, and opening the skin channel. Composed of drugs for skin barrier regulation and skin conditioning drugs to achieve the purpose of transdermal absorption, the effect of treating skin texture and wrinkles is remarkable. Because the skin around the eyes is delicate and sensitive, it is the main prone area of aging. This eye mask can play the role of decoration and sun protection.

Description of drawings

Figure 1 shows a schematic structural view of a film for sun protection and treatment of eye wrinkles.

Among them: 1-anti-adhesive layer: 2-gel layer; 3-backing layer.

Detailed ways

The present invention will be further described below in conjunction with embodiment.

Example 1

Take 10g of polyvinyl alcohol PVA-124 as the gel matrix, add 45g of water to make a glue, add 15g of silica gel, 30g of hyaluronic acid, mix, and get a gel after cooling; spread the above gel evenly on the silicon The polyester anti-adhesive layer treated with ketone is fully dried; it is covered on the backing film of aluminum-containing polyethylene composite film, sealed, and punched into a suitable size to obtain a film for sun protection and treatment of eye wrinkles.

Example 2

Take 15g of polyvinyl alcohol PVA-124 as the gel matrix, add 40g of water to make a glue, add 25g of silica gel, 20g of hyaluronic acid, mix, and get a gel after cooling; spread the above gel evenly on the silicone The treated polyester anti-adhesive layer is fully dried; covered on the backing film of aluminum-containing polyethylene composite film, sealed, punched and cut into a suitable size to obtain a film for sun protection and treatment of eye wrinkles.

Example 3

Take 20g of polyvinyl alcohol PVA-124 as the gel matrix, add 35g of water to make a glue, add 20g of silica gel, 25g of hyaluronic acid, mix, and get a gel after cooling; spread the above gel evenly on the silicone treatment The polyester anti-adhesive layer is fully dried; it is covered on the backing film of aluminum-containing polyethylene composite film, sealed, punched and cut into a suitable size, and the film for sun protection and eye wrinkles can be obtained.

Example 4

Take 20g of polyvinyl alcohol PVA-124 as the gel matrix, add 35g of water to make a glue, add 20g of silica gel, 25g of hyaluronic acid, mix, and get a gel after cooling; spread the above gel evenly on the silicone treatment On the polyester anti-adhesive layer, fully dry; covered on the backing film of aluminum-containing polyethylene composite film, the backing film is coated with personalized color pictures, with three-dimensional graphics, sealed, punched and cut into a suitable size, that is, Get sun protection and patches for eye wrinkles.

Example 5

Take 15g of polyvinyl alcohol PVA-124 as the gel matrix, add 40g of water to make a glue, add 25g of silica gel, 20g of hyaluronic acid, mix, and get a gel after cooling; spread the above gel evenly on the silicone On the treated polyester anti-adhesive layer, fully dry; covered on the backing film of aluminum-containing polyethylene composite film, the backing film is coated with personalized color pictures, with three-dimensional graphics, sealed, punched into suitable size, Instant sun protection, film for treating eye wrinkles.

Example 6

Take 10g of polyvinyl alcohol PVA-124 as the gel matrix, add 45g of water to make a glue, add 15g of silica gel, 30g of hyaluronic acid, mix, and get a gel after cooling; spread the above gel evenly on the silicon On a ketone-treated polyester release layer, fully dry; covered on a backing film of aluminum-containing polyethylene composite film, the backing film is coated with personalized color pictures, with three-dimensional graphics, sealed, die-cut to suitable size , that is, a film for sun protection and treatment of eye wrinkles.

Claims (3)

1, a kind of sun-proof, the treatment eye wrinkle-removing diaphragm, comprising:

A backing layer that is used for load active component;

The gel layer on the backing layer top that is laid in;

An adherent layer that covers on the gel layer,

Described gel layer contains PVAC polyvinylalcohol-124, silica gel, hyaluronic acid, water,

It is characterized in that: said components is by weight percentage:

PVAC polyvinylalcohol-124 10-20%

Hyaluronic acid 20-30%

Silica gel 15-25%

Water surplus.

2, according to claim 1 sun-proof, the treatment eye wrinkle-removing diaphragm, it is characterized in that: backing layer is for containing the aluminumpolyethylene composite membrane.

3, the diaphragm of sun-proof, treatment eye wrinkle-removing according to claim 1 is characterized in that: the adherent layer of being addressed for the surface through the polyester film of silicone oil release treatment.

Images