CN101000352B - Device for measuring liquid coagulating time - Google Patents
Device for measuring liquid coagulating time Download PDFInfo
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- CN101000352B CN101000352B CN200710000692XA CN200710000692A CN101000352B CN 101000352 B CN101000352 B CN 101000352B CN 200710000692X A CN200710000692X A CN 200710000692XA CN 200710000692 A CN200710000692 A CN 200710000692A CN 101000352 B CN101000352 B CN 101000352B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
- G01N11/16—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/2136—Viscosity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
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Abstract
A device used for measuring solidification time of liquid consists of sample measurement pool with measurement container and ball; liquid sample solidification-detection unit formed by support frame, measurement transducer, swinging unit and measurement circuit. It is prepared as fixing sample measurement pool on support frame of liquid solidification-detection unit.
Description
Technical field
The present invention relates to fine measuring instrument, specifically, is a kind of measurement mechanism of liquid coagulation time.
Background technology
At present, in the fine measuring instrument field, some have occurred and measured the instrument of blood viscosity.For example, No. the 200510064206.1st, the one Chinese patent application of Inst. of Mechanics, CAS, it discloses a kind of measuring instrument of real-time human body blood viscosity.This measuring instrument comprises pressure source, woven hose, micron tube, transparent capillary, demarcation liquid container, temperature conditioning unit, DATA REASONING and the processing unit of demarcation liquid, display module, control module or the like is housed.Though this quasi-instrument has the measuring accuracy height, advantage such as sampled sample is few, the structure more complicated of itself, and be not suitable for the measurement of liquid coagulation time.Up to now, the applicant does not find that still the measurement products of concrete, ripe liquid coagulation time occurs, and does not find bibliographical information yet on market.
Summary of the invention
The present invention has overcome above-mentioned shortcoming, has proposed a kind of measurement mechanism of brand-new liquid coagulation time.This device is particularly suitable for the measurement of the setting time of the big liquid of range of viscosities.
The present invention solves the technical scheme that its technical matters takes:
The measurement mechanism of liquid coagulation time of the present invention solidifies the test section by fluid sample measuring cell and liquid to be formed;
Described sample measurement pond comprises measuring vessel and ball;
Liquid solidifies the test section and comprises support, survey sensor, wig-wag, metering circuit and data processor;
The fluid sample measuring cell is fixed on liquid and solidifies on the support that detects part.
Described measuring vessel is slot type measuring vessel or tubular type measuring vessel.
The sample measurement pond partly is fixed on to solidify and detects on the support partly.Wig-wag can make the wallowing motion in support cycle and make the ball in the fluid sample measuring cell that is fixed in produce back and forth rolling; The signal time difference that is placed in that sensor on the rolling ball path detects cyclical signal that ball rolls simultaneously and measures fluid sample by metering circuit; Data processor is handled data; Liquid solidifies the variation that time difference signal is told in the test section, thereby confirms that fluid sample produces the time of solidifying after adding causes agent with fixed attention.
Solidifying to detect partly is used to make the sample measurement pond partly to swing and measure the rolling condition of ball wherein.The sensor of measuring the rolling condition of ball can adopt electro-optical pickoff or electromagnetic sensor.The sample measurement pond partly as adopt transparent material to make, sensor is placed on the path that ball rolls, when ball during through sensor, because ball causes that producing light changes photoelectric sensor can be produced and the relevant electric signal of ball motion; When using the metal ball, sensor also can use inductance type transducer or electromagnetic sensor.The same, when the metal ball rolls through sensor, sensor can be produced and the relevant electric signal of metal ball motion because the motion of metal ball causes inductance or electromagnetic change.When using the metal ball, the part of holding liquid can use non-transparent material to make.
After adding causes agent with fixed attention in the fluid sample measuring cell; Solidifying its viscosity through certain reaction time initiation fluid sample sharply increases, and the viscous resistance that ball rolls is pushed the speed and slowed down, and the signal time difference strengthens; After the time difference signal vary stable, fluid to be measured forms gluey coagulum; Or fluid to be measured solidifies the formation decorating film fully, and ball rolls and stops, and time difference signal disappears.
Solidify the test section and detect and tell these, thereby confirm that fluid to be measured produces the time of solidifying after adding causes agent with fixed attention along with viscosity changes the variation of the time difference signal that causes.
The computing formula of setting time is:
Sample setting time=T1+KT2
Wherein, TI begins to produce the time that increases variation to the fluid to be measured signal time difference after adding causes agent with fixed attention;
T2 begins to increase to the metastable time of the signal time difference fluid to be measured signal time difference, or to time that time difference signal disappears;
K is compensation coefficient, constant or function.
Advantage of the present invention is; Ball in the measurement mechanism owing in liquid, back and forth roll, therefore has good beating action during test; Can avoid measuring different viscosities different densities liquid and the inhomogeneous institute errors caused that the adding that causes agent with fixed attention produces, improve the accuracy of measuring.Thereby this device is particularly suitable for the measurement of the setting time of the big liquid of range of viscosities.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Fig. 2 is the structural representation of the measuring vessel of the embodiment of the invention 1.
Fig. 3 is the structural representation of the measuring vessel of the embodiment of the invention 2.
Fig. 4 is the vertical view in sample measurement of the present invention pond.It among the figure pair of sensors.
Fig. 5 is the vertical view in sample measurement of the present invention pond.Among the figure two pairs of sensors.
Description of reference numerals: 1. support; 2. wig-wag; 3. sample measurement pond; 4. varying-speed motor; 5. motor controller; 6. metering circuit; 7. data processor; 8. show output and keyboard; 9. sensor; 10. ball; 11. fluid to be measured.
Embodiment
Embodiment 1 comprises the measurement mechanism of slot type measuring vessel
As shown in Figure 1, this measurement mechanism solidifies the test section by sample measurement pond 3 and liquid to be formed.Sample measurement pond 3 comprises slot type measuring vessel (concrete structure of this container sees also Fig. 2) and ball 10.Ball 10 places in the slot type measuring vessel, and can roll therein.Fluid sample solidifies the test section to be made up of support 1, electro-optical pickoff 9, wig-wag 2, metering circuit 6, data processor 7, demonstration output and keyboard 8.Sample measurement pond 3 is fixed on liquid and solidifies on the support 1 of test section.Sample measurement pond part can be pulled down cleaning.
When measuring beginning, testing liquid 11 and ball 10 are joined in the sample measurement pond 3, and motor controller 5 is set.Start varying-speed motor 4, varying-speed motor 4 drives wig-wag 2 and does periodic swing.The regular swings of wig-wag 2 produce periodically back and forth the ball 10 in the sample measurement pond 3 and roll, the initial signal time difference that is placed in that sensor 9 on rolling ball 10 paths detects cyclical signal that ball rolls simultaneously and is measured fluid sample by metering circuit 6.Data processor 7, demonstration output and 8 pairs of data of keyboard are handled and input and output.After testing liquid 11 addings in sample measurement pond 3 cause agent with fixed attention; Solidifying its viscosity through certain reaction time initiation fluid sample sharply increases, and the viscous resistance that ball 10 rolls is pushed the speed and slowed down, and the signal time difference strengthens; After the time difference signal vary stable, fluid to be measured 11 forms gluey coagulum; Or fluid to be measured 11 solidifies the formation decorating film fully, and ball 10 rolls and stops, and time difference signal disappears.Solidify the test section and detect and tell these, thereby confirm that fluid to be measured 11 produces the time of solidifying after adding causes agent with fixed attention along with viscosity changes the variation of the time difference signal that causes.
As shown in Figure 4, electro-optical pickoff 9 is a pair of; And as shown in Figure 5, electro-optical pickoff 9 is two pairs.The situation of these two kinds of sensors of Fig. 4 and Fig. 5 can be selected a ground and used one of them.This is because liquid all has certain viscosity.When using two ball sensors, detect the ball that rolls and produce the signal time difference through two signals that face sensor mutually.Ball is rolled slow down, time difference signal also increases simultaneously; When using a sensor, same the ball roll signal that the tilting action of wig-wag and sensor go out has the signal time difference of a hysteresis because liquid has viscosity, and is the same, and the viscosity increase signal time difference also increases.Therefore the viscosity of the signal time difference and fluid to be measured is relevant fully and be directly proportional.
It is as shown in Figure 1 that embodiment 2 comprises the measurement mechanism of tubular type measuring vessel, and this measurement mechanism solidifies the test section by sample measurement pond 3 and liquid to be formed.Sample measurement pond 3 comprises tubular type measuring vessel (concrete structure of this container sees also Fig. 3) and ball 10.Ball 10 places in the tubular type measuring vessel, and can roll therein.Fluid sample solidifies the test section to be made up of support 1, electromagnetic sensor 9, wig-wag 2, metering circuit 6.Sample measuring cell 3 is fixed on liquid and solidifies on the support 1 of test section during use.Sample measurement pond part can be pulled down cleaning.
Present embodiment also can use pair of sensors 9 (as shown in Figure 4) as embodiment 1, also can use two pairs of sensors 9 (like Fig. 5 border).
More than the measurement mechanism of liquid coagulation time provided by the present invention has been carried out detailed introduction; Used concrete example among this paper principle of the present invention and embodiment are set forth, the explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof; Simultaneously, for one of ordinary skill in the art, according to thought of the present invention, the part that on embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.
Claims (4)
1. the measurement mechanism of a liquid coagulation time is characterized in that: solidify the test section by fluid sample measuring cell and liquid and form;
Described sample measurement pond comprises measuring vessel and ball;
Liquid solidifies the test section and comprises support, survey sensor, wig-wag, metering circuit and data processor;
The fluid sample measuring cell is fixed on liquid and solidifies on the support that detects part; Wig-wag can make the wallowing motion in support cycle and make the ball in the fluid sample measuring cell that is fixed in produce back and forth rolling; The signal time difference that is placed in that sensor on the rolling ball path detects cyclical signal that ball rolls simultaneously and measures fluid sample by metering circuit; Data processor is handled data; Liquid solidifies the variation that time difference signal is told in the test section, thereby confirms that fluid sample produces the time of solidifying after adding causes agent with fixed attention.
2. the measurement mechanism of liquid coagulation time according to claim 1, it is characterized in that: described measuring vessel is slot type measuring vessel or tubular type measuring vessel.
3. the measurement mechanism of liquid coagulation time according to claim 1, it is characterized in that: described sensor is electro-optical pickoff or electromagnetic sensor.
4. according to the measurement mechanism of claim 1 or 3 described liquid coagulation times, it is characterized in that: described sensor is a pair of or two pairs.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710000692XA CN101000352B (en) | 2007-01-17 | 2007-01-17 | Device for measuring liquid coagulating time |
| PCT/CN2007/000613 WO2008089604A1 (en) | 2007-01-17 | 2007-02-26 | A device for measuring liquid coagulation time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710000692XA CN101000352B (en) | 2007-01-17 | 2007-01-17 | Device for measuring liquid coagulating time |
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| Publication Number | Publication Date |
|---|---|
| CN101000352A CN101000352A (en) | 2007-07-18 |
| CN101000352B true CN101000352B (en) | 2012-03-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710000692XA Active CN101000352B (en) | 2007-01-17 | 2007-01-17 | Device for measuring liquid coagulating time |
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| CN (1) | CN101000352B (en) |
| WO (1) | WO2008089604A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106405120A (en) * | 2015-07-30 | 2017-02-15 | 希森美康株式会社 | Method for measuring clotting time, measurement device for clotting time, clotting time measuring reagent, and reagent kit and manufacturing usage thereof |
| CN106405119A (en) * | 2015-07-30 | 2017-02-15 | 希森美康株式会社 | Method for measuring clotting time, measurement device for clotting time, clotting time measuring reagent, and reagent kit |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103630699B (en) * | 2013-12-06 | 2015-04-15 | 北京中勤世帝生物技术有限公司 | Thrombus elasticity measuring device |
| CN109839349B (en) * | 2017-11-28 | 2021-12-07 | 北京碧澄生物科技有限公司 | Device and method for detecting liquid phase change |
| CN112881235B (en) * | 2019-11-29 | 2021-11-16 | 深圳市帝迈生物技术有限公司 | Sample analysis device and method for calculating solidification time |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4612801A (en) * | 1984-06-27 | 1986-09-23 | Antoine Girolami | Coagulometer and method of measuring of the time of coagulation of samples of fluid products |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635678A (en) * | 1969-06-13 | 1972-01-18 | Baxter Laboratories Inc | Clot-timing system and method |
| SU1168824A1 (en) * | 1984-03-27 | 1985-07-23 | Научно-Исследовательская Лаборатория Физико-Химической Механики Материалов И Технологических Процессов Главмоспромстройматериалов | Device for determining viscosity |
| DD236401A1 (en) * | 1985-04-22 | 1986-06-04 | Univ Rostock | GERINNUNGSZEITMESSGERAET |
| DE3523906A1 (en) * | 1985-07-04 | 1987-01-15 | Amelung Gmbh Heinrich | Method and device for measuring the coagulation time of liquids |
| CN86203106U (en) * | 1986-07-08 | 1987-02-18 | 上海科达测试仪器厂 | Rolling ball blood coagulation time assaying instrument |
| FR2634020B2 (en) * | 1987-12-30 | 1991-02-22 | Serbio | BOWL FOR BIOLOGICAL ANALYZER |
| CN2250523Y (en) * | 1995-07-26 | 1997-03-26 | 上海通用机电技术研究所 | Intelligent blood agglutination meter |
| FR2779827B1 (en) * | 1998-06-10 | 2000-08-11 | Junior Instruments | AUTOMATIC ANALYSIS APPARATUS FOR USE IN DETERMINING BLOOD COAGULATION TIME |
| CN1245252C (en) * | 2003-11-11 | 2006-03-15 | 石油大学(北京) | a stirring device |
| CN100549695C (en) * | 2004-04-13 | 2009-10-14 | 中国科学院力学研究所 | A kind of measuring instrument of real-time human body blood viscosity |
-
2007
- 2007-01-17 CN CN200710000692XA patent/CN101000352B/en active Active
- 2007-02-26 WO PCT/CN2007/000613 patent/WO2008089604A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4612801A (en) * | 1984-06-27 | 1986-09-23 | Antoine Girolami | Coagulometer and method of measuring of the time of coagulation of samples of fluid products |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106405120A (en) * | 2015-07-30 | 2017-02-15 | 希森美康株式会社 | Method for measuring clotting time, measurement device for clotting time, clotting time measuring reagent, and reagent kit and manufacturing usage thereof |
| CN106405119A (en) * | 2015-07-30 | 2017-02-15 | 希森美康株式会社 | Method for measuring clotting time, measurement device for clotting time, clotting time measuring reagent, and reagent kit |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008089604A1 (en) | 2008-07-31 |
| CN101000352A (en) | 2007-07-18 |
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Assignee: Beijing world emperor Scientific Instruments Inc Assignor: Li Gang Contract record no.: 2012990000397 Denomination of invention: Device for measuring liquid coagulating time Granted publication date: 20120307 License type: Exclusive License Open date: 20070718 Record date: 20120607 |
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Effective date of registration: 20130520 Address after: 102200, Changping District science and Technology Park, Beijing Road, No. 5, 4 B302 room Patentee after: BEIJING STEELLEX BIOLOGICAL TECHNOLOGY CO., LTD. Address before: 100085. Beijing world emperor Scientific Instruments Inc, No. 4, 1 Street, 25 East Road, Beijing, Haidian District Patentee before: Li Gang |
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Effective date of registration: 20150326 Address after: 102200, Changping District science and Technology Park, Beijing Road, No. 5, 4 B302 room Patentee after: BEIJING STEELLEX BIOLOGICAL TECHNOLOGY CO., LTD. Patentee after: TAIZHOU ZHONGQIN SHIDI BIOTECHNOLOGY CO., LTD. Address before: 102200, Changping District science and Technology Park, Beijing Road, No. 5, 4 B302 room Patentee before: BEIJING STEELLEX BIOLOGICAL TECHNOLOGY CO., LTD. |