CN101077338B - Nano lanthanum carbonate and orally disintegrating tablet and preparation method - Google Patents

Abstract

The invention relates to a nanometer lanthanum carbonate orally disintegrating tablet and a preparation method thereof. The main drug and auxiliary materials are dried at 40-80°C for 2-4 hours by dry compression, passed through a 100-mesh sieve, and then compressed to obtain orally disintegrating tablets. Excipients include disintegrants, fillers, effervescent agents, glidants, lubricants, flavoring agents, etc. Wet tableting is to mix the main drug and some disintegrants, fillers, flavoring agents and binders, pass through a 30-60 mesh sieve, and dry at 40-90°C for 2-10 hours; then mix with the remaining The disintegrating agent, filler, flavoring agent, effervescent agent, glidant, and lubricant are mixed evenly, and compressed into tablets to obtain orally disintegrating tablets. The pressure of the above tablet making is 2-15Mpa, the obtained orally disintegrating tablet has a hardness of 2-5kg, and the disintegration time in vitro is 20-80 seconds. The nano-lanthanum carbonate orally disintegrating tablet fully considers the mechanism of drug action, can maximize the curative effect of the drug, reduce the dosage of the patient, and improve the compliance of the patient.

Description

Nano lanthanum carbonate orally disintegrating tablet and preparation method thereof

technical field

The invention belongs to the technical field of nanometer materials and the field of pharmaceutical science.

Background technique

Hyperphosphatemia is a complication of chronic renal failure, 80% of renal dialysis patients suffer from this disease. The disease may cause bone lesions, skin itching, and even skin ulcers, etc., and also cause damage to the cardiovascular system, and 50% of patients will die as a result. Phosphate binders are currently the mainstay of treatment for hyperphosphatemia.

Phosphate binders chelate phosphorus in food, preventing its absorption from the gastrointestinal tract. The first-generation phosphorus binders are aluminum salts, which can effectively reduce the serum phosphate level in patients with chronic renal failure, but long-term use can lead to dementia and osteomalacia, so its clinical application is limited. Calcium-containing phosphate binders (eg, calcium acetate, calcium carbonate) also reduce serum phosphorus levels in patients with hyperphosphatemia but increase the incidence of hypercalcemia and calcification, especially in patients taking vitamin D Outstanding, and the patient's compliance with such drugs is poor. Therefore, people hope to develop non-aluminum, calcium-type phosphorus binders. In 1998, Genzyme Generals and GelTex Yujia Pharmaceutical Company produced Renagel tablets, which is also a drug used to treat hyperphosphatemia in patients with end-stage renal disease undergoing hemodialysis. Renagel is a polymer resin that carries multiple amine groups that can be protonated in the small intestine to be positively charged. It combines with phosphate groups in the small intestine through ion exchange and hydrogen bonding to reduce blood phosphorus. But whether Renagel can effectively inhibit parathyroid hyperplasia and reduce high PTH, and whether it has any effect on blood calcium levels, the experimental data in this area are still limited.

Lanthanum (atomic number 57, atomic mass 159) is a rare element that has a strong affinity for oxygen donor atoms. Lanthanum salts can combine with carbon oxides and phosphate compounds to produce phosphoric acid that is less water-soluble and difficult to pass through biomembranes. Lanthanum molecule. As a non-calcium, non-aluminum phosphorus binder, lanthanum chloride, lanthanum carbonate, etc. have the same effect as traditional binders on reducing the phosphate level in the patient's serum, and will not lead to an increase in serum calcium and serious side effects , and better tolerance; it will become a new generation of drugs for the treatment of hyperphosphatemia. The lanthanum carbonate drug Fosrenl launched by the British Shilling Company is a chewable tablet that was launched in 2004. Among them, the particle size of the active ingredient lanthanum carbonate is the key to affect the curative effect of the drug, and Shilling Company did not involve the particle size of the lanthanum carbonate crystal. The existing lanthanum carbonate crystal particle size is large, so the specific surface area is small, resulting in low adsorption capacity.

Contents of the invention

In order to solve the deficiencies of the prior art, the present invention proposes a nano-lanthanum carbonate orally disintegrating tablet, a preparation method thereof and a preparation method of the nano-lanthanum carbonate.

The preparation method of nanometer lanthanum carbonate orally disintegrating tablet:

1). Preparation ingredients:

Lanthanum carbonate nanocrystals: 5-40 parts

Disintegrant: 10-70 parts

Filler: 15-60 parts

Flavoring agent: 0-5 parts

Effervescent agent: 0-5 parts

Glidant: 0-4 parts

Lubricant: 0-2 parts

Adhesive: 0.5-3 parts;

Orally disintegrating tablets of nano-lanthanum carbonate were prepared by two techniques of dry compression and wet compression. Dry compression is to dry the main drug and auxiliary materials at 40-80°C for 2-4 hours, pass through a 40-100 mesh sieve, and then compress to obtain orally disintegrating tablets. Excipients include disintegrants, fillers, effervescent agents, glidants, lubricants, flavoring agents, etc. Wet tableting is to mix the main drug and some disintegrants, fillers, flavoring agents and binders, pass through a 30-60 mesh sieve, and dry at 40-90°C for 2-10 hours; then mix with the remaining The disintegrating agent, filler, flavoring agent, effervescent agent, glidant, and lubricant are mixed evenly, and compressed into tablets to obtain orally disintegrating tablets. The pressure of the above tablet making is 2-15Mpa, the obtained orally disintegrating tablet has a hardness of 2-5kg, and the disintegration time in vitro is 20-80 seconds.

The disintegrating agent is cross-linked carboxymethylcellulose sodium (cCMC-Na), cross-linked carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LSHPC), cross-linked polyvinylpyrrolidone (PPVP ) or one of microcrystalline cellulose (MCC) and a combination of two or more of the above-mentioned polymers.

The disintegrating agent is one or more polymers of cross-linked carboxymethylcellulose sodium, cross-linked carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone or microcrystalline cellulose combination of things.

The filler is one or a combination of two or more polymers of mannitol, tetrabutanol, lactose, sucrose, xylitol or sorbitol.

The flavoring agent is one or more polymers of menthol, peppermint oil, licorice, citric acid, tartaric acid, cinnamon or essence.

Described effervescent agent is sodium bicarbonate.

The glidant is micronized silica gel.

Described lubricant is magnesium stearate or talcum powder.

The binder is one or a combination of two or more polymers of povidone, polyethylene glycol, pregelatinized starch, dextrin or methylcellulose.

The lanthanum carbonate nanocrystals can be selected from existing products, and of course the lanthanum carbonate nanocrystals prepared by the method we invented can also be used.

The nano lanthanum carbonate prepared by the present invention adopts following method to prepare:

1) Prepare 0.1-10wt% stabilizer solution and 0.01-0.9mol/L lanthanum compound solution, mix the two solutions evenly, let stand for 10-30 minutes, and prepare 0.01-1.2mol/L carbonate solution Add it to the above mixed solution, control the nucleation temperature at 5-30°C, stir and react for 5-20 minutes; then continue to react at 10-50°C and stir for 30min-4h, stop stirring, and add a concentration of 0.1-5wt% surface active agent solution, and then left for 10-60 minutes;

2) Centrifuge the product obtained above for 10-40 minutes, and wash it with distilled water 2-4 times; then burn the solid dry product in a muffle furnace for 1-5 hours, the temperature is controlled at 150-400 °C, and the heating rate is 5- 10℃/min;

The stabilizer is natural macromolecular gelatin, chitosan, alginate, collagen, starch, cellulose and derivatives thereof; or polyvinyl alcohol, polyhydroxybutyrate and copolymers, polyanhydrides, polyvinyl Synthetic organic macromolecules of pyrrolidone, polyoxyethylene, polyethylene glycol; or polyols of xylitol, sorbitol, mannitol, glycerol; or polysaccharides or monosaccharides of sucrose, lactose, glucose; one of them Or a mixture of two or more.

The lanthanum compound is lanthanum chloride, lanthanum nitrate, lanthanum sulfate, lanthanum acetate or lanthanum oxalate.

Described carbonate is sodium carbonate, potassium carbonate, ammonium carbonate, sodium bicarbonate, potassium bicarbonate or ammonium bicarbonate.

The surfactant is sodium dodecylsulfonate, Span 80, Span 60 or Tween 40.

The present invention is characterized in that:

1. Nanoscale lanthanum carbonate crystals can be prepared by the precipitation method, and the nucleation and crystal growth of the crystals can be controlled by adjusting the temperature.

2. Control the crystal size by adjusting the feeding method.

3. Control the scale and shape of lanthanum carbonate crystals by utilizing the adsorption, stabilization and space confinement effects of stabilizer molecules.

4. Adding surfactant can make crystal dispersion more uniform and prevent agglomeration.

Nano-lanthanum carbonate orally disintegrating tablets fully consider the mechanism of drug action, which can maximize the curative effect of the drug, reduce the dosage of the patient, and improve the compliance of the patient.

Description of drawings

Figure 1: Electron microscope scanning photo of nano-lanthanum carbonate;

Figure 2: Partial enlarged view of the scanning electron microscope photo of nano-lanthanum carbonate.

Detailed ways

Example 1

First prepare 1wt% gelatin solution, 0.3mol/L sodium carbonate solution, and 0.2mol/L lanthanum chloride solution for use, then take out 50ml of lanthanum chloride solution, add 20ml of gelatin solution, and stir to make it evenly mixed. Use an ice/water mixture water bath to control the temperature at 5°C, add 50ml of sodium carbonate solution, stir for 10 minutes, then raise the temperature at a rate of 3°C/min until it stops at 30°C, react at this temperature for 30 minutes, and then add 1 wt% of dodecyl Sodium alkyl sulfonate 0.2ml, and left for 20min. Put the turbid liquid into a centrifuge for separation for 30 minutes (3000r/min, the same below), take out the sediment, wash with water 3 times, and place the obtained sediment in a crucible. Put the crucible containing the product into a muffle furnace and heat it at a rate of 10°C/min until 400°C, bake it at this temperature for 1 hour, and then cool it down to room temperature naturally to obtain nano-lanthanum carbonate crystals. See Figure 1 and Figure 1. 2.

Example 2

First prepare 0.1wt% polyoxyethylene solution, 0.06mol/L potassium carbonate solution, and 0.04mol/L lanthanum nitrate solution for use, then take out 50ml of lanthanum nitrate solution, add 20ml of polyethylene glycol solution, and stir to make it evenly mixed. Use an ice/water mixture water bath to control the temperature at 10°C, add 50ml of potassium carbonate solution, stir for 15min, then raise the temperature at a rate of 5°C/min until it stops at 30°C, and react at this temperature for 50min, then add 0.2ml of 0.1wt% Span 80, and leave it for 40min. Put the obtained emulsion into a centrifuge for separation for 40 minutes, take out the sediment, wash it twice with water, and place the obtained sediment in a crucible. The crucible was put into a muffle furnace and fired at a heating rate of 5°C/min until 300°C, fired at this temperature for 0.5 hour, and then naturally cooled to room temperature to obtain nano-lanthanum carbonate crystals.

Example 3

First prepare 10wt% glycerol solution, 1.2mol/L ammonium bicarbonate solution, and 0.9mol/L lanthanum acetate solution for use, then take out 100ml lanthanum acetate solution, add 2ml glycerol solution, and stir to make it evenly mixed. Use an ice/water mixture water bath to control the temperature at 15°C, add 100ml of ammonium bicarbonate solution drop by drop, complete the addition in 20 minutes, stir and react for 5 minutes, then raise the temperature at a rate of 2°C/min until it stops at 25°C, and react at this temperature for 70 minutes , and then adding 0.5ml of Tween 40 with a concentration of 5wt%, and standing for 30min. Put the turbid liquid in a centrifuge for separation for 20 minutes, take out the sediment, wash it with water 4 times, and place the sediment in a crucible. The crucible containing the product was heated in a muffle furnace at a heating rate of 10°C/min until 250°C, baked at this temperature for 1 hour, and then cooled naturally to room temperature to obtain lanthanum carbonate nanocrystals.

Example 4

First prepare 2wt% lactose solution, 0.6mol/L sodium bicarbonate solution, and 0.4mol/L lanthanum sulfate solution for use, then take out 80ml of lanthanum carbonate solution, add 3ml of lactose solution, and stir to make it evenly mixed. Use an ice/water mixture water bath to control the temperature at 12°C, add 80ml of sodium bicarbonate solution, stir for 5 minutes, then raise the temperature at a rate of 3°C/min until it stops at 30°C, react at this temperature for 40 minutes, and then add 0.5ml of 1wt% Tween 40, and left for 30min. Put the turbid liquid in a centrifuge for separation for 20 minutes, take out the sediment, wash it with water 3 times, and place the obtained sediment in a crucible. The crucible containing the product was heated in a muffle furnace at a heating rate of 5°C/min until 150°C, baked at this temperature for 1 hour, and then cooled naturally to room temperature to obtain lanthanum carbonate nanocrystals.

Example 5

First prepare 1wt% polyoxyethylene solution, 2wt% polyvinyl alcohol, 0.015mol/L sodium bicarbonate solution, 0.01mol/L lanthanum sulfate solution for use, then take out 100ml lanthanum carbonate solution, add 3ml polyoxyethylene solution and 3ml Polyvinyl alcohol solution, stir to make it evenly mixed. Control the temperature with a water bath to 30°C, add 100ml of sodium bicarbonate solution, stir and react for 20 minutes, then raise the temperature at a rate of 3°C/min until it stops at 50°C, react at this temperature for 40 minutes, and then add 0.5ml of 1 wt% spitan Temperature 40, and place for 30min. Put the turbid liquid in a centrifuge for separation for 20 minutes, take out the sediment, wash it with water 3 times, and place the obtained sediment in a crucible. The crucible containing the product was heated in a muffle furnace at a heating rate of 5°C/min until 300°C, baked at this temperature for 1 hour, and then cooled naturally to room temperature to obtain lanthanum carbonate nanocrystals.

Example 6

First prepare 0.5wt% gelatin solution, 0.1wt% polyoxyethylene solution, 1wt% sorbitol, 0.6mol/L sodium carbonate solution, 0.4mol/L lanthanum chloride solution for use, then take out 50ml lanthanum chloride solution, add 20ml Gelatin, polyoxyethylene, sorbitol solution, stir to make it evenly mixed. Use an ice/water mixture water bath to control the temperature at 12°C, add 50ml of sodium carbonate solution, stir for 15 minutes, then raise the temperature at a rate of 3°C/min until it stops at 30°C, react at this temperature for 30 minutes, and then add 1wt% polyethylene Base pyrrolidone 0.1ml, and left for 20min. Put the turbid liquid into a centrifuge for separation for 30 minutes (3000r/min, the same below), take out the sediment, wash with water 3 times, and place the obtained sediment in a crucible. Put the crucible containing the product into a muffle furnace and heat it at a rate of 14°C/min until 400°C, bake it at this temperature for 1 hour, and then cool it naturally to room temperature to obtain nano-lanthanum carbonate crystals

Example 7

Get 12 parts of lanthanum carbonate nanocrystals and 38 parts of mannitol in the example 2 that above-mentioned make fully mix, then mix with 35 parts of microcrystalline cellulose, 3 parts of PPVP, 6 parts of LSHPC dried at 60 ℃ for 3 hours, and pass 100-mesh sieve, then add 1 part of sodium bicarbonate, 2 parts of micropowdered silica gel, 1.5 parts of magnesium stearate, 1 part of citric acid and 0.5 part of orange essence, mix well, and then compress the tablet under a pressure of 5Mpa to obtain oral disintegration solution piece. The tablet hardness is 3kg, and the in vitro disintegration time limit is 53s.

Example 8

Get 7 parts of lanthanum carbonate nanocrystals prepared above and fully mix them with 24 parts of xylitol and 15 parts of lactose, then mix them evenly with 28 parts of microcrystalline cellulose dried at 60°C for 3 hours, and 11 parts of LSHPC, and pass through an 80-mesh sieve , then add 5 parts of sodium bicarbonate, 3 parts of micropowder silica gel, 3 parts of talcum powder, 3 parts of citric acid and 1 part of licorice, mix well, and then compress under a pressure of 10Mpa to obtain orally disintegrating tablets. The tablet hardness is 5kg, and the in vitro disintegration time limit is 75s.

Example 9

Get 10 parts of above-mentioned prepared lanthanum carbonate nanocrystals and fully mix with 23 parts of tetrabutanol and 10 parts of lactose, then mix evenly with 36 parts of microcrystalline cellulose dried at 60° C. for 5 hours, and 14 parts of low-substituted hydroxypropyl cellulose, And pass through 80 mesh sieve, then add 2 parts of sodium bicarbonate, 2 parts of micropowder silica gel, 1 part of magnesium stearate, 1 part of citric acid and 1 part of licorice, mix well, and then compress under 7Mpa pressure to obtain oral disintegration solution piece. The tablet hardness is 4kg, and the in vitro disintegration time limit is 15s

Example 10

Get 19 parts of the lanthanum carbonate nanocrystals prepared above and fully mix them with 14 parts of mannitol, 5 parts of sorbitol, and 2 parts of sucrose, then mix them with 42 parts of microcrystalline cellulose dried at 60°C for 3 hours, 10 parts of croscarmellose Sodium cellulose cellulose (cCMC-Na), 2 parts of croscarmellose sodium starch (CMS-Na) were mixed evenly, and passed through a 100-mesh sieve, and then 1.5 parts of sodium bicarbonate, 2 parts of micropowdered silica gel, 0.5 part of stearin Magnesium acid, 1 part of citric acid and 1 part of menthol, and mixed uniformly, and then compressed under a pressure of 3Mpa to obtain orally disintegrating tablets. The tablet hardness is 3kg, and the in vitro disintegration time limit is 38s.

Example 11

Get 22 parts of the lanthanum carbonate nanocrystals prepared above and fully mix them with 25 parts of xylitol and 16 parts of lactose, then mix them evenly with 37 parts of microcrystalline cellulose dried at 60°C for 3 hours, pass through a 100-mesh sieve, and mix them evenly , and then compressed under a pressure of 10Mpa to obtain orally disintegrating tablets. The tablet hardness is 5kg, and the in vitro disintegration time limit is 83s.

Example 12

Get 16 parts of the lanthanum carbonate nanocrystals prepared above and fully mix them with 24 parts of xylitol and 21 parts of lactose, then mix them evenly with 26 parts of microcrystalline cellulose dried at 60°C for 4 hours, and 10 parts of LSHPC, and pass through an 80-mesh sieve , and then add 2 parts of micropowdered silica gel and 1 part of talc powder, mix well, and then compress the tablet under a pressure of 10Mpa to obtain an orally disintegrating tablet. The tablet hardness is 5kg, and the in vitro disintegration time limit is 46s.

Example 13

Get 20 parts of lanthanum carbonate (produced by Weihai Baidexin New Material Co., Ltd.), fully mix with 20 parts of xylitol and 24 parts of sucrose, then mix evenly with 34 parts of microcrystalline cellulose dried at 60°C for 5 hours, and pass through 80 mesh Sieve, then add 1 part of micropowder silica gel and 1 part of talc powder, mix well, and then compress the tablet under a pressure of 10 MPa to obtain an orally disintegrating tablet. The tablet hardness is 4kg, and the in vitro disintegration time limit is 59s.

Example 14

Get 10 parts of above-mentioned lanthanum carbonate nanocrystals and 10 parts of mannitol, 10 parts of microcrystalline cellulose, 1 part of sucrose, 3 parts of PPVP, 0.5 parts of citric acid and 5 parts of povidone ethanol-water solution (concentration is 10wt% ) were thoroughly mixed, passed through a 40-mesh sieve, and dried at 60°C for 4 hours; then mixed with 28 parts of microcrystalline cellulose dried at 60°C for 3 hours, 12 parts of LSHPC, 1 part of PPVP, 15 parts of mannitol, and 2 parts of lactose Mix well and pass through an 80-mesh sieve; then add 1 part of sodium bicarbonate, 2 parts of micropowdered silica gel, 2 parts of magnesium stearate, 1 part of citric acid and 1 part of menthol, mix well, and then press under a pressure of 5Mpa tablets to obtain orally disintegrating tablets. The tablet hardness is 3.5kg, and the in vitro disintegration time limit is 58s.

Example 15

Get 15 parts of above-mentioned lanthanum carbonate nanocrystals and 14 parts of mannitol, 12 parts of microcrystalline cellulose, 1 part of sucrose, 5 parts of LSHPC, 1 part of croscarmellose sodium starch (CMS-Na), 0.5 parts of citric acid Mix well with 1 part of PEG and 2 parts of dextrin (aqueous solution with a concentration of 25wt%), pass through a 40-mesh sieve, and dry at 50°C for 6 hours; then dry with 24 parts of microcrystalline cellulose, Mix 7 parts of LSHPC, 3 parts of PPVP, 10 parts of xylitol, and 2 parts of lactose evenly, and pass through a 100-mesh sieve; then add 0.5 parts of sodium bicarbonate, 1.5 parts of micronized silica gel, 1 part of magnesium stearate, 0.5 parts of citric acid and 0.5 pineapple flavor, and mixed evenly, then compressed under 4Mpa pressure to obtain orally disintegrating tablets. The tablet hardness is 3kg, and the in vitro disintegration time limit is 49s.

Example 16

Take 40 parts of lanthanum carbonate nanocrystals prepared above, mix well with 20 parts of mannitol, and 16 parts of microcrystalline cellulose, pass through a 40-mesh sieve, and dry at 60°C for 5 hours; then dry with 21 parts of 60°C for 3 hours microcrystalline cellulose, 3 parts of polyethylene glycol and passed through a 100-mesh sieve; mixed evenly, and then compressed under a pressure of 10Mpa to obtain an orally disintegrating tablet. The tablet hardness is 5kg, and the in vitro disintegration time limit is 80s.

Example 17

Get 6 parts of above-mentioned lanthanum carbonate nanocrystals and 5 parts of mannitol, 5 parts of sorbitol, 10 parts of microcrystalline cellulose, 8 parts of croscarmellose sodium, 5 parts of low-substituted hydroxypropyl cellulose, and 1 part of sucrose , 2 parts of PPVP, 0.5 citric acid and 3 parts of povidone ethanol-water solution (concentration is 10wt%) are fully mixed, passed through a 40-mesh sieve, and dried at 60°C for 3 hours; then dried with 20 parts of 60°C for 3 hours Microcrystalline cellulose, 9 parts of LSHPC, 1 part of PPVP, 15 parts of mannitol, and 1.5 parts of lactose were mixed evenly and passed through an 80-mesh sieve; then 1 part of sodium bicarbonate, 0.5 parts of micropowder silica gel, and 4 parts of magnesium stearate were added , 1.5 parts of citric acid and 1 part of menthol, and mix uniformly, then compress the tablet under a pressure of 5Mpa to obtain an orally disintegrating tablet. The tablet hardness is 3.5kg, and the in vitro disintegration time limit is 58s.

The present invention is not limited to the technology described in the embodiment, its description is illustrative, not restrictive, the authority of the present invention is defined by the claims, based on those skilled in the art can change and reorganize according to the present invention The technologies related to the present invention obtained by such methods are all within the protection scope of the present invention.

Claims (7)

1. A preparation method of nanometer lanthanum carbonate orally disintegrating tablet: 1). Preparation ingredients: Nano lanthanum carbonate: 5-40 parts Disintegrant: 10-70 parts Filler: 15-60 parts Flavoring agent: 0-5 parts Effervescent sodium bicarbonate: 0-5 parts Glidant micropowder silica gel: 0-4 parts Lubricants magnesium stearate or talc: 0-2 parts Adhesive: 0.5-3 parts; 2) The components are dried at 40-80°C for 2-4 hours, passed through a 40-100 mesh sieve, and then compressed into tablets to obtain orally disintegrating tablets; Described nano-lanthanum carbonate adopts following method to prepare: 1) Prepare 0.1-10wt% stabilizer solution and 0.01-0.9mol/L lanthanum compound solution, mix the two solutions evenly, let stand for 10-30 minutes, and prepare 0.01-1.2mol/L carbonate solution Add it to the above mixed solution, control the nucleation temperature at 5-30°C, stir and react for 5-20 minutes; then continue to react at 10-50°C and stir for 30min-4h, stop stirring, and add a concentration of 0.1-5wt% surface active agent solution, and then left for 10-60 minutes; Centrifuge the product obtained above for 10-40 minutes, and wash it with distilled water 2-4 times; then burn the solid dry product in a muffle furnace for 1-5 hours, the temperature is controlled at 150-400°C, and the heating rate is 5-10°C /min; The stabilizer is natural macromolecular gelatin, chitosan, alginate, collagen, starch or cellulose; or polyvinyl alcohol, polyhydroxybutyrate and copolymers, polyanhydrides, polyvinylpyrrolidone, polyoxygen Ethylene, polyethylene glycol; or polyols of xylitol, sorbitol, mannitol, and glycerin; or sucrose, lactose, glucose; one or more of them are used in combination. 2. the preparation method of nano-lanthanum carbonate orally disintegrating tablet as claimed in claim 1, it is characterized in that the pressure of the obtained nano-lanthanum carbonate orally disintegrating tablet is 2-15Mpa, and the gained orally disintegrating tablet hardness is 2～5kg, The in vitro disintegration time is 20-80 seconds. 3. the preparation method of nanometer lanthanum carbonate orally disintegrating tablet as claimed in claim 1 or 2, it is characterized in that described disintegrant is cross-linked sodium carboxymethyl cellulose, cross-linked sodium carboxymethyl starch, low A combination of one or two or more polymers replacing hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone or microcrystalline cellulose. 4. the preparation method of lanthanum carbonate nanocrystal orally disintegrating tablet as claimed in claim 1 is characterized in that described filler is a kind of of mannitol, tetrabutanol, lactose, sucrose, xylitol or sorbitol Or a combination of two or more polymers. 5. the preparation method of lanthanum carbonate nanocrystal orally disintegrating tablet as claimed in claim 1 or 2 is characterized in that described corrective agent is menthol, peppermint oil, licorice, citric acid, citric acid, tartaric acid, A combination of one or more polymers of cinnamon or essence. 6. the preparation method of nano-lanthanum carbonate orally disintegrating tablet as claimed in claim 1 or 2 is characterized in that described binding agent is povidone, polyethylene glycol, pregelatinized starch, dextrin or formazan A combination of one or two or more polymers based on cellulose. 7. the preparation method of nano-lanthanum carbonate orally disintegrating tablet as claimed in claim 1 or 2 is characterized in that described lanthanum compound is lanthanum chloride, lanthanum nitrate, lanthanum sulfate, lanthanum acetate or lanthanum oxalate; Carbonate It is sodium carbonate, potassium carbonate, ammonium carbonate, sodium bicarbonate, potassium bicarbonate or ammonium bicarbonate; the surfactant is sodium dodecyl sulfonate, Span 80, Span 60 or Tween 40.

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