CN101377517A - Automatic analyzer - Google Patents

Abstract

The present invention can provide a cleaning mechanism that can be reliably inserted into the reaction container without reducing the suction performance of the cleaning liquid, without increasing the size of the reaction container and the device, and without being affected by the accuracy of the stop position of the reaction container. automatic analysis device. A positioning member is attached to a nozzle holder provided with a cleaning liquid suction nozzle to which a suction member is attached. The positioning member is located at a lower position than the suction member and can move up and down. When the cleaning mechanism descends, it approaches and inserts the reaction container before the suction member, so that the stop position of the reaction container deviates. Correct the insertion position of the suction unit if necessary.

Description

Automatic analysis device

technical field

The present invention relates to an automatic analyzer for analyzing biological samples such as blood and urine, and more particularly to an automatic analyzer equipped with a cleaning mechanism for cleaning.

Background technique

An automatic analyzer for qualitative and quantitative analysis of biological samples such as blood and urine, reacts the sample and reagents in a reaction container, and analyzes the components to be measured in the sample. The reaction container is formed of a material such as plastic or glass, and is usually cleaned and reused after one measurement is completed. The cleaning operation of the reaction container is usually carried out as follows: After moving the reaction container to a predetermined cleaning position, suck the reaction liquid (waste liquid after measurement) with a nozzle, repeat injection and suction with water and cleaning water for a predetermined number of times, and finally Attracts wash water. At this time, a suction member (cleaning sheet) shaped to follow the inner wall of the reaction container is often attached to the tip of the nozzle so that cleaning water does not remain in the reaction container after cleaning the reaction container. Patent Document 1 (Patent Document 1: Japanese Unexamined Patent Application Publication No. 10-062431) describes a technique in which the shape of the suction member is specified so as to reduce the absorption residue of washing water as much as possible.

As described in Patent Document 1, in order to reduce the absorption residue of cleaning water as little as possible, the general guideline is to make the gap (clearance) between the cleaning sheet and the inner wall of the reaction vessel as small as possible. On the other hand, the smaller the clearance, the higher the positioning accuracy of the reaction vessel in the cleaning position is required. In automatic analyzers, miniaturization of the reaction container and high speed of operation are required, such as miniaturization of the device, high-speed processing capacity, and micronization of specimens and samples. Therefore, in the case of simply reducing the clearance, there is a high possibility that the cleaning sheet collides with the reaction container and causes failure.

Contents of the invention

The object of the present invention is to provide the reliability of a cleaning mechanism that can reliably insert the reaction container without reducing the suction performance of the cleaning liquid, without increasing the size of the reaction container and the device, and without being affected by the accuracy of the stop position of the reaction container. High-precision automatic analysis device.

In order to achieve the above objects, the present invention is constituted as follows.

Equipped with: a reaction container for mixing a sample and a reagent; a reaction plate for setting and transporting the above reaction container to a cleaning position; a cleaning water suction nozzle for sucking the cleaning water of the above reaction container; and attaching to the cleaning water suction nozzle A suction member; and an automatic analysis device of a moving mechanism for moving the cleaning water suction nozzle, which is provided with a mechanism for inserting the cleaning water suction nozzle into the reaction container based on the position of the positioning guide provided on the reaction container. Mode, the control unit that controls the above-mentioned moving mechanism.

The specific example is as follows. At least include: a reaction container for mixing the sample and reagent; a reaction plate for setting and transporting the above reaction container to the cleaning position; a cleaning water suction nozzle for sucking and discharging the cleaning water injected into the above reaction container; The suction part at the tip of the water suction nozzle; the nozzle holder that holds the cleaning water suction nozzle; the arm for moving up and down connected to the nozzle holder; and the moving mechanism and motor such as the feed screw that moves the arm up and down In the automatic analysis device, a positioning member is installed on the nozzle holder of the cleaning liquid suction nozzle equipped with the suction member, and the positioning member is made to be located at a position lower than the suction member and can move up and down. A cone is provided on the shape of the front end of the positioning member, and when the cleaning mechanism descends, it approaches and inserts the reaction vessel before the suction member. When the stop position of the reaction vessel deviates, the insertion position of the suction member is corrected. to the exact location. In addition, in order to achieve the above object, according to the present invention, in the above-mentioned automatic analyzer, a convex (or concave) positioning guide pin (or tapered hole) is provided on the above-mentioned reaction container, and a concave hole is provided on the side of the positioning member. (or convex) tapered hole (or guide pin). The positioning part is made to be located at a lower position than the suction part and can move up and down. When the cleaning mechanism is descending, the convex part of the reaction vessel The concave part (or concave part) and the concave part (or convex part) of the positioning member are approached and inserted into the reaction container before the suction part, and the insertion position of the suction part is corrected to an accurate position when the stop position of the reaction container deviates.

According to the present invention, it is possible to reliably insert the suction member into the reaction container when cleaning the reaction container, and to correct the insertion position of the suction member to an accurate position when the stop position of the reaction container deviates. automatic analysis device.

Description of drawings

FIG. 1 is a diagram showing a state in which washing water is not sucked in an embodiment of the prior art.

Fig. 2 is a state diagram when washing water is sucked in an embodiment of the conventional art.

Fig. 3 is a state diagram of suction of washing water in the embodiment in which a cone is attached to the tip of the suction member.

Fig. 4 is a view in which a cone is installed at the inlet of the reaction vessel.

Fig. 5 is a diagram showing a state in which washing water is not sucked in the embodiment of the present invention.

Fig. 6 is a state diagram when washing water is sucked in the embodiment of the present invention.

Fig. 7 is a diagram showing a state in which washing water is not sucked in another embodiment of the present invention.

Fig. 8 is a state diagram when washing water is sucked in another embodiment of the present invention.

Explanation of symbols: 1—reaction container, 1a—cone on the inlet side of the reaction container, 1b—reaction container position A, 1c—reaction container position B, 1d—reaction container position C, 2—nozzle for cleaning water suction, 3—pumping Suction part, 3a—cone at front end of suction part, 4—nozzle holder, 5—arm, 6—feed screw, 7—motor, 8—spring for cushioning, 9—part A for positioning, 9a—shaft , 9b—spring, 9c—fixer, 10—nozzle holder, 11—movable part, 12—guiding pin for positioning, 13—part B for positioning, 13a—tapered hole.

Detailed ways

By adding positioning parts to the nozzle holder of the cleaning mechanism, the purpose of the present invention is achieved, that is, to provide a cleaning water suction device that does not reduce the suction performance of the cleaning liquid and does not increase the size of the reaction vessel and the device. A highly reliable automatic analysis device with a cleaning mechanism that reliably inserts the suction part into the reaction vessel.

[Example 1]

1 and 2 are schematic diagrams showing the structure of a conventional cleaning mechanism.

In FIG. 1 , a reaction vessel 1 is set on a reaction tray. The cleaning mechanism is composed of: a nozzle 2 for suction of cleaning water; a suction member 3 mounted on the front end of the nozzle 2 for suction of cleaning water; a nozzle holder 4 for holding the nozzle 2 for suction of cleaning water; The arm 5 to which the holder 4 is connected; the feed screw 6 and the motor 7 which move the arm 5 up and down; the spring 8 for buffering the cleaning suction nozzle; and the like. Fig. 1 shows the state of the cleaning mechanism and the reaction container when the cleaning water is not sucked. Fig. 2 is the state of the cleaning mechanism and the reaction container when the cleaning water is sucked. The arm 5 is lowered by means of the motor 7 and the feed screw 6. At the same time, the nozzle holder 4 connected to the arm 5 is set on the nozzle holder The cleaning water suction nozzle 2 and the suction member 3 on the member 4 are also lowered to be inserted into the reaction container 1 moved to a predetermined cleaning position, and the cleaning water in the reaction container 1 is sucked and discharged. The clearance between the suction member 3 and the inner wall of the reaction container 1 is small, and if the stop position of the reaction container deviates due to the accumulation of dimensional errors of the components, etc., the suction member 3 may come into contact with the inlet of the reaction container 1 and Jamming, failure to insert an alarm that stops the automatic analyzer. In order to prevent the suction part 3 from contacting the reaction vessel 1, it may be considered to install a cone 3a at the front end of the suction part 3 as shown in Figure 3, or to install a cone at the inlet side of the reaction vessel 1 as shown in Figure 4. 1a to correct the insertion position, and when the cone 3a is installed at the front end of the suction member 3 as shown in Figure 3, the clearance between the cone portion and the inner wall of the reaction vessel becomes large, and it is likely that the cleaning solution cannot be sucked. In addition, in the case where the cone 1a is installed on the inlet side of the reaction vessel 1 as shown in FIG. 4, since at least a distance of about 0.5 mm is required for the cone portion, it increases from 2.5 mm to 3.5 mm, that is, increases by about 1.4 times. Therefore, the distance between adjacent reaction vessels reaches the size of the set reaction plate must be increased, therefore, problems remain in the miniaturization of the reaction vessel and the miniaturization of the device.

Then, the operation of the first embodiment of the present invention that solves the above problems will be described with reference to FIGS. 5 , 6 , 7 , and 8 .

In FIG. 5 , the positioning parts are composed of a positioning member A9, a shaft 9a, a spring 9b, and a fixing member 9c, and are mounted on the nozzle holder 10 so as to be movable up and down. In addition, a movable member 11 is additionally provided at the connecting portion between the nozzle holder 10 and the arm 5 so that the nozzle holder 10 can move slightly laterally when the reaction vessel 1 and the positioning member A9 are guided to each other. The positional relationship between the positioning member A9 and the suction member 3 is the same as that of the adjacent reaction vessels 1 . In addition, the positioning member A9 in a state where water is not sucked is positioned lower than the suction member 3 . Fig. 6 is a state when washing water is sucked, and the arm 5, the nozzle holder 10, the nozzle 2 for washing water suction, and the suction member 3 are lowered similarly to the state of Fig. 2 . At this time, although the positioning member A9, the shaft 9a, the spring 9b, and the fixing member 9c also descend, the positioning member A9 approaches the reaction vessel 1 first because it is lower than the suction member 3. The positioning member A9 descends to the reaction vessel position B1c and the reaction vessel position C1d adjacent to the reaction vessel position A1b into which the suction member 3 is inserted. Since the front end of the positioning part A9 is a cone shape, the clearance between the inner wall of the reaction vessel 1 and the front end of the positioning part A9 can be made larger, so it is easy to enter the reaction vessel 1, and the positioning part A9 will draw the suction part 3 The insertion position is corrected to the exact position. At this time, the lateral movement of the nozzle holder 10 is assisted by the movable member 11 . Therefore, since the shape and size of the suction member 3 and the reaction container 1 are not changed, it is possible to provide a suction device that does not reduce the suction performance of the cleaning solution, and does not increase the size of the reaction container and the device, and the suction member can be reliably inserted into the reaction container. Automatic analyzer with high reliability of cleaning mechanism.

Fig. 7 and Fig. 8 are another embodiment of the scheme 1 of the present invention. In FIG. 7 , a convex (or concave) positioning guide pin 12 (or a tapered hole) is provided on the reaction vessel 1 . In addition, a concave (or convex) tapered hole 13a (or guide pin) that matches the positional relationship of the positioning guide pin 12 is provided on the positioning member B13, similarly to FIG. The positioning member B13 in the state is at a position lower than the suction member 3 . Fig. 8 is a state when washing water is sucked, and the arm 5, the nozzle holder 10, the nozzle 2 for washing water suction, and the suction member 3 are lowered in the same manner as in the state of Fig. 2 . At this time, although the positioning member B13, the shaft 9a, the spring 9b, and the fixing member 9c also descend, the positioning member B13 approaches the reaction vessel 1 first because it is lower than the suction member 3. The positioning member B13 descends to the positioning guide pin 12 adjacent to the reaction vessel position A1b into which the suction member 3 is inserted. At this time, the concave (or convex) tapered hole 13a (or guide pin) matched with the positional relationship of the convex (or concave) positioning guide pin 12 arranged on the reaction vessel 1 is inserted, Since the clearance between the guide pin 12 for positioning and the concave (or convex) tapered hole 13a of the component B13 for positioning can be made larger in the same way as the above-mentioned embodiment, it is easy to enter the reaction vessel 1 for positioning. The guide pin 12 and the positioning member B13 correct the insertion position of the suction member 3 to an accurate position. At this time, the lateral movement of the nozzle holder 10 is assisted by the movable member 11 . Therefore, since the shape and size of the suction member 3 and the reaction container 1 are not changed, it is possible to provide the suction performance without reducing the cleaning liquid, and the suction member 3 can be reliably inserted into the reaction chamber without increasing the size of the reaction container and the device. An automatic analyzer with high reliability of the cleaning mechanism of the container 1.

Claims (4)

1. automatic analysing apparatus possesses:

Reaction vessel with sample and reagent mix;

With above-mentioned reaction vessel setting and be transported to the reaction tray of cleaning positions;

Attract the rinse water of the rinse water of above-mentioned reaction vessel to attract ozzle;

Be installed in the pumping part on this rinse water attraction ozzle; And

The travel mechanism that makes this rinse water attract ozzle to move is characterized in that,

Possess control module, this control module is to control above-mentioned travel mechanism based on the position that is arranged on the locating guider on the above-mentioned reaction vessel with the mode that above-mentioned rinse water attracts ozzle to insert reaction vessel.

2. automatic analysing apparatus according to claim 1 is characterized in that,

Above-mentioned locating guider is pilot pin or bellmouth.

3. automatic analysing apparatus according to claim 2 is characterized in that,

Above-mentioned travel mechanism possesses bellmouth or the pilot pin chimeric with above-mentioned locating guider.

4. automatic analysing apparatus according to claim 3 is characterized in that,

The set bellmouth of above-mentioned travel mechanism or pilot pin also lean on the below than above-mentioned pumping part.

Images