CN101856531A - High-efficiency dry powder inhaler for medicament delivery and medicament delivery method thereof - Google Patents
High-efficiency dry powder inhaler for medicament delivery and medicament delivery method thereof Download PDFInfo
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- CN101856531A CN101856531A CN 201010210062 CN201010210062A CN101856531A CN 101856531 A CN101856531 A CN 101856531A CN 201010210062 CN201010210062 CN 201010210062 CN 201010210062 A CN201010210062 A CN 201010210062A CN 101856531 A CN101856531 A CN 101856531A
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- 229940112141 dry powder inhaler Drugs 0.000 title claims abstract description 54
- 238000002716 delivery method Methods 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 89
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims description 88
- 230000000694 effects Effects 0.000 claims description 44
- 239000008187 granular material Substances 0.000 claims description 43
- 239000011859 microparticle Substances 0.000 claims description 24
- 210000000214 mouth Anatomy 0.000 claims description 10
- 210000003928 nasal cavity Anatomy 0.000 claims description 10
- 230000002685 pulmonary effect Effects 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 240000007817 Olea europaea Species 0.000 claims description 9
- 210000000621 bronchi Anatomy 0.000 claims description 9
- 210000002345 respiratory system Anatomy 0.000 claims description 9
- 241000276425 Xiphophorus maculatus Species 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 8
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- 230000007812 deficiency Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a high-efficiency dry powder inhaler for medicament delivery and a medicament delivery method thereof, and relates to the technical field of medical equipment. The dry powder inhaler is characterized in that: a center island is arranged between a central groove of an upper cover body and a central groove of a lower cover body and the center island, the upper cover body and the lower cover body are compressed and connected into a whole to form a primary air inlet, a lower channel, a lower auxiliary air inlet, an air intake channel, a symmetrical channel, an upper auxiliary air inlet, an air duct, an upper channel and an air outlet, the front end of the center island arranged at the bottom of the air intake channel, the rear end of the center island arranged at the bottom of the air duct; and the lower channel, the symmetrical channel, the lower auxiliary air inlet, the upper auxiliary air inlet and the upper channel are communicated with one another. The method comprises the following steps of: putting a suction nozzle in the mouth; inhaling after an anther sac is put at the lower end of the main air inlet so as to make medicinal powder enter the lower channel after the medical powder passes through the main air inlet; scattering a gas-medicament mixture with the airflow of the lower auxiliary air inlet through the shearing and impact when the gas-medicament mixture reaches the front end of the center island; scattering the gas-medicament mixture with the airflow of the upper auxiliary air inlet again through the shearing and impact when the gas-medicament mixture reaches the rear section of the center island; scattering the gas-medicament mixture again when the gas-medicament mixture reaches the rear end of the center island, then mixing to form appropriate aerodynamic-size particles and sending the particles to the scheduled position of the patient. The dry powder inhaler of the invention is used for the patient to inhale the medicament.
Description
Technical field
The present invention is used for the high-efficiency dry powder inhaler and the medicament delivery method thereof of drug conveying, relates to technical field of medical instruments; Be specifically related to the technical field of medical instruments that main part adopts no activity single part to design.
Background technology
Diskus is that medicine directly is transferred to respiratory system, mucosal tissue by respiratory system and then effect on human body target tissue, reaches fast the effectively medical apparatus and instruments of the inhalation-type drug administration of treatment.Because direct, convenient, characteristics fast and efficiently that Diskus has, since the 1970's emerged, the inhaler of existing hundreds and thousands of kinds of different designs thinkings was used at field of medicaments.1., can't effectively control the particulate aerodynamic force size of suitable medicated powder but up to the present, its ubiquitous deficiency, defective and drawback are concluded and are:.Reasonably drug particles aerodynamic force size is the key that drug particles effectively is transferred.The drug particles aerodynamic force that pulmonary administration requires is of a size of the 0.5-5 micron, crosses conference and deposits to nasal cavity or throat and can't arrive the expection position, too small then can breathe out with expiration external.But micron-sized micropowder is very easily reunited, conventional Diskus can't be dispersed as granule between the 0.5-5 micron, that have suitable aerodynamic force size with the ultra-fine medicated powder of reuniting effectively, therefore can be deposited on positions such as nasal cavity, throat, bronchus because of granule is excessive, can't arrive default medicine-feeding parts such as deep lung.About about 10%, the drug conveying of this poor efficiency causes a large amount of wastes of pharmaceutical compositions to the pulmonary delivery efficient of most of products usually greatly in the market.2., because of due to the pulmonary function difference of individual patients, can't provide enough medicated powder dosage than weak person for pulmonary function.3., Diskus is made of multi-part (especially movable part), its flow resistance can't obtain stable control.Because of the gap of its each parts with cooperate, particularly gap and the matching problem between activity and fixed part is even more serious.This unsettled flow resistance has caused the air-flow of actual suction can't reach the stabilizing gas flow of designing requirement, causes the medicated powder dosage of actual suction inaccurate and unstable; Also exist complex operation simultaneously, use inconvenience, and the common fault that assembling procedure is numerous and diverse, manufacturing cost is higher.Professional knowledge based on the inventor reaches the excelsior unremitting pursue of cause with the working experience of enriching, on conscientiously and fully investigation, understanding, analysis, the above-mentioned existing known technology of summary basis, the spy takes " global design of inhaler main part no-movable part is fully broken up reunion medicated powder granule to utilize the air-flow multiple impact " key technology, and the high-efficiency dry powder inhaler and the medicament delivery method thereof that are used for drug conveying are provided.
Summary of the invention
The present invention takes " global design of inhaler main part no-movable part is fully broken up reunion medicated powder granule to utilize the air-flow multiple impact " key technology, and " high-efficiency dry powder inhaler that is used for drug conveying " new product and " medicament delivery method " thereof are provided.The new product of its " high-efficiency dry powder inhaler that is used for drug conveying ": be connected the as a whole primary air inlet that has constituted whole lower end place successively thereby place the central island compacting between the central recess by the central recess of upper cover body and lower cover, lower channel in the loading district, the following auxilairy air intake of described loading district and connection, mixed zone and the air intake duct that extends to central island thereof, the left-right symmetric passage that constitutes between mixed zone and central island, the mixed zone is by the last secondary inlet of upper end and the airway that extends to central island thereof, the upper channel in the suction nozzle and the gas outlet of upper end, the front end of central island and the rear end that place, airway bottom has constituted central island have also been constituted simultaneously at place, air intake duct bottom, the left-right symmetric passage is in the connection of central island front end place and extend to the rear end connection that two passage back segments extend to central island again, lower channel, the left-right symmetric passage, following auxilairy air intake, last secondary inlet, upper channel is connected.Its " medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying " is: suction nozzle is contained inlet, medicine bag places the primary air inlet lower end, active inspiration, reunion medicated powder granule in the medicine bag enters lower channel through primary air inlet, gas and the medicine mixture bump under the high velocity air generation high shear force state of central island front end and following auxilairy air intake, the medicated powder granule is broken up, continuation marches to back segment along central island, further broken up with secondary impact to the medicated powder granule under the high speed lateral airflow generation high shear force state of last auxilairy air intake, continue to march to the central island rear end and converge also mixed at high speed again, this intensive mixing effect of impact has played the effect that the medicated powder granule is further broken up for the third time, and finally break up drug microparticles into suitable aerodynamic force size, drug microparticles with suitable aerodynamic force size enters patient's oral cavity through upper channel with air-flow, and deposit to nasal cavity and bronchus, predetermined respiratory system position until pulmonary, be absorbed by the tissue mucosa, to reach therapeutic purposes.
The purpose that reaches by the present invention is: 1., take " global design of inhaler main part no-movable part ", make " high-efficiency dry powder inhaler that is used for drug conveying " new equipment of providing scientific and reasonable for structure, simply ingenious, be convenient to make, with low cost.2., provide with " high-efficiency dry powder inhaler that is used for drug conveying " and carry out " medicament delivery method ", make medicine in course of conveying by multiple impact and fully broken up, obtain " drug microparticles of suitable aerodynamic force size ".3., make " drug microparticles of suitable aerodynamic force size " can enter the patient oral cavity smoothly and deposit to nasal cavity and bronchus, until the predetermined respiratory system position of pulmonary, reach therapeutic purposes to be absorbed by the tissue mucosa.4., eliminating existing known technology actually awards dose also different drawbacks because the different individual variation of vital capacity is existing between each human body, make that no matter patient's vital capacity size all can obtain to reach the sufficient dose of therapeutic effect, thereby all can reach desired therapeutic effect.5., method is simple, convenient fast, directly quick-acting, effect stability is reliable, is convenient to wide popularization and application.
For achieving the above object, technical scheme provided by the invention is:
A kind of high-efficiency dry powder inhaler and medicament delivery method thereof that is used for drug conveying of patent application of the present invention, take " global design of inhaler main part no-movable part ", make the inhaler main part that constitutes " high-efficiency dry powder inhaler that is used for drug conveying " new product not have movable part, there is not the cooperation between parts clearance and the parts, all unfavorable conditions that prior art may occur have been eliminated, from structure fundamentally fully guaranteed can utilize the air-breathing air-flow of patient dexterously, and " utilizing the air-flow multiple impact reunion medicated powder granule fully to be dispersed as the medicated powder microparticle that is fit to the aerodynamic force size ", strengthen the speed and the effect of the smooth and easy patient's of the entering predetermined position of medicated powder microparticle effectively, reached the therapeutic purposes of optimum efficiency then.The present invention includes " high-efficiency dry powder inhaler that is used for drug conveying ", " medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying ".
A kind of high-efficiency dry powder inhaler that is used for drug conveying is: be connected the as a whole primary air inlet that has constituted described whole lower end place successively thereby place the central island compacting between the central recess by the central recess of upper cover body and lower cover, lower channel in the loading district, the following auxilairy air intake of described loading district and connection, mixed zone and the air intake duct that extends to described central island thereof, left passage that constitutes between described mixed zone and the described central island and right passage, described mixed zone is by the last secondary inlet of upper end and the airway that extends to described central island thereof, the upper channel in the suction nozzle and the gas outlet of upper end, the front end of described central island and the rear end that place, described airway bottom has constituted described central island have also been constituted simultaneously at the place, bottom of described air intake duct, the rear end that described left passage is connected at the front end place of described central island with described right passage and the back segment that extends to described two passages extends to described central island again is connected described lower channel, described left passage and described right passage, described auxilairy air intake down, the described secondary inlet that goes up, described upper channel is connected.
The described high-efficiency dry powder inhaler that is used for drug conveying, described upper cover body and lower cover be provided with overlook/or look up to the lower end that is the flat central recess of olive shape and be communicated with the lower channel groove and the upper end is communicated with upper channel groove and the whole lid shape structure that is similar to the traditional Chinese cake mold, described central island is olivary platy structure, and the total depth of the degree of depth sum of described upper cover body and the two flat central recess of lower cover equals the thickness of described central island.
The described high-efficiency dry powder inhaler that is used for drug conveying, the diameter of described primary air inlet, lower channel, following auxilairy air intake and the air intake duct of extension, left passage and right passage, the airway of going up secondary inlet and extension thereof, upper channel, gas outlet is the 0.5-50 millimeter, and the cross sectional shape of described lower channel, air intake duct, left passage and the right passage of auxilairy air intake extension down, the airway of going up the secondary inlet extension, upper channel is a kind of shape of selecting in rectangle, ellipse, rhombus, circle, triangle, pentagon, the hexagon.
The described high-efficiency dry powder inhaler that is used for drug conveying, the angle that is constituted between the airway that airway that the air intake duct that air intake duct that described left passage and right passage, left passage and following auxilairy air intake extend and right passage and following auxilairy air intake extend, left passage and last secondary inlet are extended and right passage and last secondary inlet are extended is 1-180 degree angle.
The described high-efficiency dry powder inhaler that is used for drug conveying, the end of described upper channel also is provided with the suction nozzle cover.
The described high-efficiency dry powder inhaler that is used for drug conveying, described upper cover body and lower cover all also can be selected to be provided with olive shape center half cavity and to be provided with the lower end in vertical mode on the inwall of described half cavity by described lid to be communicated with the lid shape structure that lower channel groove and upper end be communicated with the upper channel groove and to substitute.
The described high-efficiency dry powder inhaler that is used for drug conveying, described central island and mixed zone all also can be selected to be substituted by olivary stereo structure structure.
A kind of medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying, for the logic set forth and be convenient to deeply understand to of the present invention, the spy takes the mode of sequence number to narrate, and actual medicament delivery method of the present invention is successive and organically blend a process integral body.That is: 1., use the above high-efficiency dry powder inhaler that is used for drug conveying (hereinafter to be referred as inhaler); 2., remove the suction nozzle cover on the inhaler, the patient contains the suction nozzle of inhaler in the inlet, the medicine bag that contains medicated powder and open opening is placed the primary air inlet lower end of inhaler; 3., when patient's active inspiration, under the air-flow effect of patient's active inspiration, the reunion medicated powder granule in the medicine bag just enters the lower channel of inhaler along with sucking the air-flow primary air inlet through inhaler without stop; When 4., entering the front end place of powder mixes body central island in arriving the inhaler mixed zone of the air-flow of lower channel and medicated powder, still under the air-flow effect of described patient's active inspiration, just with the high velocity air generation high shear force state that enters by auxilairy air intake under the side under effect of impact, this effect of impact is dispersed as less medicated powder granule with reunion medicated powder granule; 5., the less medicated powder granule after breaing up continues along advancing in the mode that symmetry makes progress around the left passage and the right passage of central island, when advancing to the back segment place of left passage and right passage, be still under the air-flow effect of described patient's active inspiration, just make carry the particulate air-flow of less medicated powder once more with by lateral secondary impact effect of going up under the high speed lateral airflow generation high shear force state that auxilairy air intake enters inhaler, this effect of impact is further broken up drug particles; 6., the mode that still makes progress with symmetry in left passage and right passage of the mixture of drug particles of further being broken up and air-flow continues to advance, when advancing to the rear end of central island, just converge again and mixed at high speed, this intensive mixing effect of impact has also played the effect that the medicated powder granule is further broken up for the third time simultaneously, and finally breaks up the drug microparticles into suitable aerodynamic force size; 7., the drug microparticles with suitable aerodynamic force size enters patient's oral cavity with the upper channel of air-flow in the inhaler suction nozzle, and deposit to nasal cavity and bronchus, until the predetermined respiratory system position of pulmonary, tissue adherence by human body is absorbed, and reaches therapeutic purposes with this.
The described medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying, described medicine bag also can be substituted by cartridge case or recessed bubble, and the lower channel front end that is used for the high-efficiency dry powder inhaler of drug conveying also can be provided with the fixedly auxiliary device of medicine bag, cartridge case or recessed bubble.
Owing to adopted technical scheme provided by the present invention, make the present invention compare with existing known technology, obtained following beneficial effect:
1, as long as the present invention's vital capacity size of patient no matter patient's active inspiration, just can make reunion medicated powder granule in the medicine bag finish by primary air inlet and air-flow lower channel with competent dose and enter, and has eliminated the existing drawback of individual variation.
2, because the present invention is provided with lower channel, the down air intake duct that extends of auxilairy air intake, the front end of central island, but obtained agglomerated medicated powder granule at lower channel, the bump under the mutual junction generation high shear force state of the air intake duct that extends of auxilairy air intake, central island front end and finish and be dispersed as the particulate beneficial effect of less medicated powder down.
3, because the present invention is provided with left and right sides passage, goes up the airway of auxilairy air intake and extension thereof, obtained to make to be dispersed as less medicated powder granule and the secondary impact under the high shear force state to take place once more and finish the beneficial effect of further breaing up at left and right sides passage and the airway junction (being the back segment of left and right sides passage) that last auxilairy air intake extends.
4, because the present invention is provided with central island rear end, passage rear end, the left and right sides, upper channel front end, obtained to make the medicated powder granule further broken up in the central island rear end, the junction of passage rear end, the left and right sides, upper channel front end converges and mixed at high speed again, finishes the beneficial effect of further breaing up for the third time and finally breaing up to suitable aerodynamic force size drug microparticles simultaneously.
5, because the present invention is provided with upper channel and gas outlet, obtained to make the drug microparticles of suitable aerodynamic force size to enter the patient oral cavity and deposit to nasal cavity and bronchus, until the predetermined respiratory system position of pulmonary, be absorbed and reach the beneficial effect of treatment by the tissue adherence of human body.
6, because above each bar of the present invention is described, thus the beneficial effect that has obtained to take " global design of inhaler main part no-movable part is fully broken up reunion medicated powder granule to utilize the air-flow multiple impact " key technology and " high-efficiency dry powder inhaler that is used for drug conveying " new product and " medicament delivery method " thereof are provided.
7, because primary air inlet of the present invention, lower channel, the air intake duct of following auxilairy air intake and extension thereof, left side passage and right passage, the airway of last secondary inlet and extension thereof, upper channel, the diameter of gas outlet is the 0.5-50 millimeter, described lower channel, the air intake duct that following auxilairy air intake extends, left side passage and right passage, the airway that last secondary inlet is extended, the cross sectional shape of upper channel is the selection rectangle, oval, rhombus, circular, triangle, pentagon, a kind of shape in the hexagon, thus the beneficial effect that equivalent variation forms similar derived product obtained.
8, because the angle that is constituted between the airway that airway that the air intake duct that air intake duct that left passage of the present invention and right passage, left passage and following auxilairy air intake extend and right passage and following auxilairy air intake extend, left passage and last secondary inlet are extended and right passage and last secondary inlet are extended is 1-180 degree angle, obtained the beneficial effect that equivalent variation forms similar derived product equally.
9, since upper cover body of the present invention and lower cover all also can select to be provided with olive shape center half cavity and on the inwall of described half cavity, to be provided with the lower end to be communicated with the lid shape structure that lower channel groove and upper end be communicated with the upper channel groove and to substitute in vertical mode by described lid, and central island and mixed zone all also can select to be substituted by olivary stereo structure structure, obtained the beneficial effect that equivalent variation forms similar derived product equally.
10, also be provided with the suction nozzle cover owing to upper channel end of the present invention, thereby obtained to guarantee the beneficial effect of health.
11, because medicine bag of the present invention also can be alternative by cartridge case or recessed bubble, the front end of inhaler lower channel also can be provided with the fixedly auxiliary device of medicine bag, cartridge case or recessed bubble, thereby has obtained and can implement to suck and the beneficial effect of wide accommodation to various granule medicines.
12, the above described explanation of each bar of the present invention has fully realized " global design of inhaler main part no-movable part is fully broken up reunion medicated powder granule to utilize the air-flow multiple impact " general idea and the beneficial effect that general idea is implemented.
13, the above described explanation of each bar of the present invention, its design science is reasonable, simple and ingenious structure, method is simple, convenient fast, directly quick-acting, thus obtained to be easy to be made low, effect stability reliable, be convenient to the beneficial effect of wide popularization and application.
14,, thereby obtained to overcome the beneficial effect of existing known technology deficiency, defective and drawback because above each bar of the present invention is described.
Description of drawings
Fig. 1 is the schematic perspective view of " high-efficiency dry powder inhaler that is used for drug conveying " main body embodiment in the specific embodiment of the invention; The promptly subsidiary schematic perspective view that medicine bag is arranged.Dotted line among the figure is represented the situation of advancing of air-flow and air-flow and medicated powder blend of granules whose.
Fig. 2 is that the A-A of Fig. 1 is to generalized section.Dotted line among the figure is represented the situation of advancing of air-flow and air-flow and medicated powder blend of granules whose.
Fig. 3 is that the B-B of Fig. 1 is to generalized section.Not subsidiary medicine bag among this figure.
Fig. 4 is " high-efficiency dry powder inhaler that is used for drug conveying " in the specific embodiment of the invention embodiment schematic perspective view at Fig. 1 first-class variation in basis formation one of similar derived product; Not subsidiary medicine bag among this figure; Dotted line among the figure is represented the situation of advancing of air-flow and air-flow and medicated powder blend of granules whose.Similar derived product in Fig. 1 first-class variation in basis also can be a lot, do not embody one by one at this.
Label among the figure: 1, primary air inlet, 2, the loading district, 3, the mixed zone, 4, suction nozzle, 5, the gas outlet, 6, go up secondary inlet, 7, following auxilairy air intake, 8, medicine bag, 9, reunion medicated powder granule, 10, lower channel, 11, front end (being the front end of mixed zone), 12, left passage, 13, right passage, 14, back segment (being the back segment of gas channel), 15, rear end (being the rear end of mixed zone), 16, upper channel, 17, central island.
The specific embodiment one
Below in conjunction with Figure of description, the present invention is described in detail.Shown in Figure of description 1,2,3:
A kind of high-efficiency dry powder inhaler that is used for drug conveying, thereby place central island 17 compactings between the central recess by the central recess of upper cover body and lower cover and be connected the as a whole primary air inlet 1 that has constituted described whole lower end place successively, lower channel 10 in the loading district 2, described loading district 2 and the following auxilairy air intake 7 of 3 connections, mixed zone and the air intake duct that extends to described central island 17 thereof, the left passage 12 and the right passage 13 that constitute between described mixed zone 3 and the described central island 17, described mixed zone 3 is by the last secondary inlet 6 of upper end and the airway that extends to described central island 17 thereof, the upper channel 16 in the suction nozzle 4 and the gas outlet 5 of upper end, the front end 11 of described central island 17 and the rear end 15 that place, described airway bottom has constituted described central island 17 have also been constituted simultaneously at the place, bottom of described air intake duct, 15 places, rear end that described left passage 12 is connected at front end 11 places of described central island 17 with described right passage 13 and the back segment 14 that extends to described two passages extends to described central island 17 again are connected described lower channel 10, described left passage 12 and described right passage 13, described auxilairy air intake 7 down, the described secondary inlet 6 that goes up, described upper channel 16 is connected.
The described high-efficiency dry powder inhaler that is used for drug conveying, described upper cover body and lower cover be provided with overlook/or look up to the lower end that is the flat central recess of olive shape and be communicated with the lower channel groove and the upper end is communicated with upper channel groove and the whole lid shape structure that is similar to the traditional Chinese cake mold, described central island (17) is olivary platy structure, and the total depth of the degree of depth sum of described upper cover body and the two flat central recess of lower cover equals the thickness of described central island (17).
The described high-efficiency dry powder inhaler that is used for drug conveying, described primary air inlet 1, lower channel 10, following auxilairy air intake 7 and the air intake duct that extends thereof, left side passage 12 and right passage 13, last secondary inlet 6 and the airway that extends thereof, upper channel 16, the diameter of gas outlet 5 is the 0.5-50 millimeter, described lower channel 10, the air intake duct that following auxilairy air intake 7 extends, left side passage 12 and right passage 13, the airway that last secondary inlet 6 is extended, the cross sectional shape of upper channel 16 is the selection rectangle, oval, rhombus, circular, triangle, pentagon, a kind of shape in the hexagon.
The described high-efficiency dry powder inhaler that is used for drug conveying, the angle that is constituted between the airway that airway that the air intake duct that air intake duct that described left passage 12 and right passage 13, left passage 12 and following auxilairy air intake 7 extend and right passage 13 and following auxilairy air intake 7 extend, left passage 12 and last secondary inlet 6 are extended and right passage 13 and last secondary inlet 6 are extended is 1-180 degree angle.
The described high-efficiency dry powder inhaler that is used for drug conveying, the end of described upper channel 16 also is provided with the suction nozzle cover.
The described high-efficiency dry powder inhaler that is used for drug conveying, described upper cover body and lower cover all also can be selected to be provided with olive shape center half cavity and to be provided with the lower end in vertical mode on the inwall of described half cavity by described lid to be communicated with the lid shape structure that lower channel groove and upper end be communicated with the upper channel groove and to substitute.
The described high-efficiency dry powder inhaler that is used for drug conveying, described central island 17 and mixed zone 3 all also can be selected to be substituted by olivary stereo structure structure.
In above-mentioned implementation process: the diameter to described primary air inlet 1, lower channel 10, following auxilairy air intake 7 and the air intake duct, left passage 12 and the right passage 13 that extend, the airway of going up secondary inlet 6 and extension thereof, upper channel 16, gas outlet 5 is implemented with 0.5,1,5,10,15,20,25,30,35,40,45,50 millimeter respectively; Described lower channel 10, air intake duct, left passage 12 and the right passage 13 of auxilairy air intake 7 extensions down, the airway of going up secondary inlet 6 extensions, the cross sectional shape of upper channel 16 are implemented with rectangle, ellipse, rhombus, circle, triangle, pentagon, hexagon respectively; The angle that is constituted between the airway of the air intake duct that air intake duct that described left passage 12 and right passage 13, left passage 12 and following auxilairy air intake 7 are extended and right passage 13 and following auxilairy air intake 7 extend, left passage 12 and 6 extensions of last secondary inlet and the airway of right passage 13 and 6 extensions of last secondary inlet is spent angles with 15,10,20,30,50,75,100,120,140,160,180 respectively and is implemented; Described upper cover body and lower cover all also are communicated with structure that lower channel groove and upper end be communicated with the upper channel groove and substitute and implement being arranged to olive shape center half cavity and being provided with the lower end in vertical mode on the inwall of described half cavity; Described central island 17 is also implemented to be substituted by olivary stereo structure structure; All obtained the good result of expection.
The specific embodiment two
On the specific embodiment one basis, implement, shown in Figure of description 4: just to as described in upper cover body and lower cover all be arranged to olive shape center half cavity and as described in be provided with the lower end in vertical mode on the inwall of half cavity and be communicated with the structure that lower channel groove and upper end are communicated with the upper channel groove, also described central island 17 and mixed zone 3 all are arranged to olivary stereo structure structure simultaneously; Obtained the good result of expection equally.
The specific embodiment three
On the enforcement basis of the specific embodiment one, two, implement:
A kind of high-efficiency dry powder inhaler that is used for drug conveying comprises the inhaler agent structure, and in order to store medicine bag, cartridge case or recessed bubble and the adnexaes such as fixture, suction nozzle cover thereof of drug powder.
The inhaler agent structure comprises at least one primary air inlet, at least one auxilairy air intake, at least one mixed zone, at least one airflow channel structure and at least one gas outlet, and inside, mixed zone is provided with at least one central island structure.
Primary air inlet is used for being stored in the drug powder in importing medicine bag, cartridge case or the recessed bubble, importing inhaler main body under the autonomous air-breathing air-flow effect that produces of patient;
Auxilairy air intake is used for importing the autonomous air-breathing air-flow that produces of patient and forms turbulent flow, forms bump with the air-flow that is loaded with drug powder in the gas channel, thereby the drug powder of reuniting is broken up;
The central island structure of inside, mixed zone is divided into the gas channel of at least two forks in order to the air-flow that will be loaded with drug powder, and steering current forms the branch, and guiding branch intermingling bump, thereby the drug powder of reuniting is further broken up;
The drug powder that the gas outlet is used for breaing up imports in the patient oral cavity, deposits to human bodies such as nasal cavity, bronchus or pulmonary, thereby reaches therapeutic purposes.
The diameter of described primary air inlet, auxilairy air intake, each gas channel, gas outlet is the 0.5-50 millimeter, and the cross sectional shape of described primary air inlet, auxilairy air intake, each gas channel, gas outlet is for selecting a kind of shape in rectangle, ellipse, rhombus, circle, triangle, pentagon, the hexagon.The size and the cross sectional shape of the primary air inlet by selecting Diskus, auxilairy air intake, each gas channel, gas outlet, control reunion medicated powder granule breaks up degree, the aerodynamic force size of the medicated powder microparticle after breaing up and the speed that the medicated powder microparticle enters the patient oral cavity, optimize the particulate efficient of breaing up of medicated powder of reuniting, thereby reach the purpose of accurate control medicated powder microparticle deposition site.
Between described gas channel and the gas channel, between gas channel and the auxilairy air intake, the angle that constituted between gas channel and auxilairy air intake air intake duct, gas channel and the gas outlet of extending is 1-180 degree angle.By between the gas channel and gas channel of selecting Diskus, between gas channel and the auxilairy air intake, the angle that constituted between air intake duct, gas channel and the gas outlet of gas channel and auxilairy air intake extension, control reunion medicated powder granule breaks up degree, the aerodynamic force size of the medicated powder microparticle after breaing up and the speed that the medicated powder microparticle enters the patient oral cavity, optimize the particulate efficient of breaing up of medicated powder of reuniting, thereby reach the purpose of accurate control medicated powder microparticle deposition site.
The diameter of central island structure is the 0.5-50 millimeter in the described mixed zone, and the cross sectional shape of described central island is for selecting a kind of shape in rectangle, ellipse, rhombus, circle, triangle, pentagon, the hexagon.The size and the cross sectional shape of the central island structure by selecting Diskus, thereby the shape and the rum point of the gas channel of control fork, control reunion medicated powder granule break up degree and break up after the aerodynamic force size of medicated powder microparticle, optimize the particulate efficient of breaing up of medicated powder of reuniting, and then reach the purpose of accurate control medicated powder microparticle deposition site.
The front end setting of described air inlet can be provided with medicine bag, cartridge case or the adnexaes such as recessed bubble and fixture thereof in order to the storage drug powder, and the end of described gas outlet can be provided with adnexaes such as suction nozzle cover.
The described high-efficiency dry powder inhaler that is used for drug conveying is the medical Diskus of first kind of main part no-movable part in the world, can adopt single part or multipart design, wherein the design of single part has been eliminated the multi-part Diskus, especially contained the Diskus of movable part because the inhaler flow resistance that gap between the parts and matching problem are caused is unstable and then drug conveying the dosage inaccurate and unsettled disadvantage brought, and is cheap for manufacturing cost, easy and simple to handle, be easy to operation and maintenance.
According to the described high-efficiency dry powder inhaler that is used for drug conveying of claim 1, the efficient medical Diskus of this patent invention, can be by selecting the size and shape of primary air inlet, auxilairy air intake, each gas channel, gas outlet and central island structure, the overall flow resistance of control Diskus under specific suction pressure, thereby improve the particulate efficient of breaing up of medicated powder of reuniting, make the more weak patient of lung functions when using Diskus, also can access enough medicated powder dosage.
Based on the design principle of inhaler of the present invention, thereby quantity, increase that can be by increasing or reduce auxilairy air intake or the branch number that reduces gas channel be divided into air-flow more or less branch and increase or reduce the number of rum point, the mixed zone at central island place is changed over stereochemical structure etc. change and form the similar derivative product.
Under the prerequisite that keeps inhaler internal structure design principle of the present invention, the external shape of inhaler can be designed to different shapes such as pen type, whistle type, mobile phone type, but the change of this external shape does not influence breaing up of medicated powder and transfer efficiency.
A kind of medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying, 1., use the described high-efficiency dry powder inhaler (hereinafter to be referred as inhaler) that is used for drug conveying; 2., remove the suction nozzle cover on the inhaler, the patient contains the suction nozzle of inhaler in the inlet, medicine bag, cartridge case or the recessed bubble that contains medicated powder is placed the primary air inlet lower end of inhaler; 3., when patient's active inspiration, under the air-flow effect of patient's active inspiration, the reunion medicated powder granule in medicine bag, cartridge case or the recessed bubble just enters the lower channel of inhaler along with sucking air-flow through the primary air inlet of inhaler; When 4., entering the front end place of powder mixes body central island in arriving the inhaler mixed zone of the air-flow of lower channel and medicated powder, still under the air-flow effect of described patient's active inspiration, with the effect of impact under the high velocity air generation high shear force state that is entered by the side auxilairy air intake, this effect of impact is dispersed as less medicated powder granule with reunion medicated powder granule; 5., the less medicated powder granule after breaing up continues along advancing around the gas channel of central island, when advancing to the back segment place of gas channel, be still under the air-flow effect of described patient's active inspiration, make carry the particulate air-flow of less medicated powder once more with the high speed lateral airflow generation high shear force state that enters inhaler by lateral auxilairy air intake under the secondary impact effect, this effect of impact is further broken up drug particles; 6., the mixture of drug particles of further being broken up and air-flow is when advancing to the rear end of central island, again converge and mixed at high speed, this intensive mixing effect of impact has also played the effect that the medicated powder granule is further broken up for the third time simultaneously, and finally breaks up the drug microparticles into suitable aerodynamic force size; 7., the drug microparticles with suitable aerodynamic force size enters patient's oral cavity with the passage of air-flow in the inhaler suction nozzle, and deposit to nasal cavity, bronchus, until the predetermined respiratory system position of pulmonary, tissue adherence by human body is absorbed, and reaches therapeutic purposes with this.
The specific embodiment four
On the enforcement basis of the specific embodiment one, two, implement, emphasis is with reference to Figure of description 2,1., use the described high-efficiency dry powder inhaler (hereinafter to be referred as inhaler) that is used for drug conveying a kind of medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying, the mode of taking sequence number are to successively and the narration implemented of the procedure integral body that organically blends:; 2., remove the suction nozzle cover on the inhaler, the patient contains the suction nozzle 4 of inhaler in the inlet, the medicine bag 8 that contains medicated powder and open opening is placed primary air inlet 1 lower end of inhaler; 3., when patient's active inspiration, under the air-flow effect of patient's active inspiration, the reunion medicated powder granule 9 in the medicine bag 8 just enters the lower channel 10 of inhaler along with sucking the air-flow primary air inlet 1 through inhaler without stop; When 4., entering front end 11 places of powder mixes body central island 17 in arriving inhaler mixed zone 3 of the air-flow of lower channel 10 and medicated powder, still under the air-flow effect of described patient's active inspiration, just with the high velocity air generation high shear force state that enters by auxilairy air intake under the side 7 under effect of impact, this effect of impact is dispersed as less medicated powder granule with reunion medicated powder granule 9; 5., the less medicated powder granule after breaing up continues to advance in the mode that symmetry makes progress with right passage 13 along the left passage 12 around central island 17, when advancing to back segment 14 places of left passage 12 and right passage 13, be still under the air-flow effect of described patient's active inspiration, just make carry the particulate air-flow of less medicated powder once more with by lateral secondary impact effect of going up under the high speed lateral airflow generation high shear force state that auxilairy air intake 6 enters inhaler, this effect of impact is further broken up drug particles; 6., the mode that still makes progress with symmetry in left passage 12 and right passage 13 of the mixture of drug particles of further being broken up and air-flow continues to advance, when 15 places, rear end that advance to central island 17, just converge again and mixed at high speed, this intensive mixing effect of impact has also played the effect that the medicated powder granule is further broken up for the third time simultaneously, and finally breaks up the drug microparticles into suitable aerodynamic force size; 7., the drug microparticles with suitable aerodynamic force size enters patient's oral cavity with the upper channel 16 of air-flow in inhaler suction nozzle 4, and deposit to nasal cavity and bronchus, until the predetermined respiratory system position of pulmonary, tissue adherence by human body is absorbed, and reaches therapeutic purposes with this.
The described medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying, described medicine bag 8 also can be substituted by cartridge case or recessed bubble.
In above-mentioned specific implementation process, described medicine bag 8 is also substituted and implemented by cartridge case, recessed bubble respectively, obtained the good result of expection equally.
Being preferred embodiment of the present invention only below, is not that the present invention is done any pro forma restriction; The those of ordinary skill of all industry all can be implemented smoothly; But make the equivalent variations of differentiation not breaking away from technical solution of the present invention, be equivalent embodiment of the present invention, all still belong to technical scheme of the present invention.
Claims (9)
1. high-efficiency dry powder inhaler that is used for drug conveying, it is characterized in that: place central island (17) between the central recess by the central recess of upper cover body and lower cover thus compacting is connected the as a whole primary air inlet (1) that has constituted described whole lower end place successively, lower channel (10) in the loading district (2), described loading district (2) and the following auxilairy air intake (7) of connection, mixed zone (3) and the air intake duct that extends to described central island (17) thereof, the left passage (12) and the right passage (13) that constitute between described mixed zone (3) and the described central island (17), described mixed zone (3) is by the last secondary inlet (6) of upper end and the airway that extends to described central island (17) thereof, the upper channel (16) in the suction nozzle (4) and the gas outlet (5) of upper end, the front end (11) of described central island (17) and the rear end (15) that place, described airway bottom has constituted described central island (17) have also been constituted simultaneously at the place, bottom of described air intake duct, described left passage (12) and described right passage (13) locate to be connected described lower channel (10) in the rear end (15) that the front end (11) of described central island (17) is located to be connected and the back segment (14) that extends to described two passages extends to described central island (17) again, described left passage (12) and described right passage (13), described auxilairy air intake (7) down, the described secondary inlet (6) that goes up, described upper channel (16) is connected.
2. according to the described high-efficiency dry powder inhaler that is used for drug conveying of claim 1, it is characterized in that: described upper cover body and lower cover be provided with overlook/or look up to the lower end that is the flat central recess of olive shape and be communicated with the lower channel groove and the upper end is communicated with upper channel groove and the whole lid shape structure that is similar to the traditional Chinese cake mold, described central island (17) is olivary platy structure, and the total depth of the degree of depth sum of described upper cover body and the two flat central recess of lower cover equals the thickness of described central island (17).
3. according to the described high-efficiency dry powder inhaler that is used for drug conveying of claim 1, it is characterized in that: described primary air inlet (1), lower channel (10), following auxilairy air intake (7) and the air intake duct that extends thereof, left side passage (12) and right passage (13), last secondary inlet (6) and the airway that extends thereof, upper channel (16), the diameter of gas outlet (5) is the 0.5-50 millimeter, described lower channel (10), the air intake duct that following auxilairy air intake (7) extends, left side passage (12) and right passage (13), the airway that last secondary inlet (6) is extended, the cross sectional shape of upper channel (16) is the selection rectangle, oval, rhombus, circular, triangle, pentagon, a kind of shape in the hexagon.
4. according to the described high-efficiency dry powder inhaler that is used for drug conveying of claim 1, it is characterized in that: the angle that is constituted between the airway that airway that the air intake duct that air intake duct that described left passage (12) and right passage (13), left passage (12) and following auxilairy air intake (7) extend and right passage (13) and following auxilairy air intake (7) extend, left passage (12) and last secondary inlet (6) are extended and right passage (13) and last secondary inlet (6) are extended is 1-180 degree angle.
5. according to the described high-efficiency dry powder inhaler that is used for drug conveying of claim 1, it is characterized in that: the end of described upper channel (16) also is provided with the suction nozzle cover.
6. according to claim 1 or the 2 described high-efficiency dry powder inhalers that are used for drug conveying, it is characterized in that: described upper cover body and lower cover all also can be selected to be provided with olive shape center half cavity and to be provided with the lower end in vertical mode on the inwall of described half cavity by described lid to be communicated with the lid shape structure that lower channel groove and upper end be communicated with the upper channel groove and to substitute.
7. according to claim 1 or the 2 described high-efficiency dry powder inhalers that are used for drug conveying, it is characterized in that: described central island (17) and mixed zone (3) all also can be selected to be substituted by olivary stereo structure structure.
1., application rights requires the 1 described high-efficiency dry powder inhaler (hereinafter to be referred as inhaler) that is used for drug conveying 8. medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying is characterized in that:; 2., remove the suction nozzle cover on the inhaler, the patient contains the suction nozzle (4) of inhaler in the inlet, the medicine bag (8) that contains medicated powder and open opening is placed primary air inlet (1) lower end of inhaler; 3., when patient's active inspiration, under the air-flow effect of patient's active inspiration, the reunion medicated powder granule (9) in the medicine bag (8) just enters the lower channel (10) of inhaler along with sucking the air-flow primary air inlet through inhaler (1) without stop; 4., enter the front end (11) of powder mixes body central island (17) in arriving inhaler mixed zone (3) of the air-flow of lower channel (10) and medicated powder when locating, still under the air-flow effect of described patient's active inspiration, just with the high velocity air generation high shear force state that enters by auxilairy air intake under the side (7) under effect of impact, this effect of impact is dispersed as less medicated powder granule with reunion medicated powder granule (9); 5., the less medicated powder granule after breaing up continues to advance in the mode that symmetry makes progress with right passage (13) along the left passage (12) around central island (17), when the back segment (14) that advances to left passage (12) and right passage (13) when locating, be still under the air-flow effect of described patient's active inspiration, just make carry the particulate air-flow of less medicated powder once more with by lateral secondary impact effect of going up under the high speed lateral airflow generation high shear force state that auxilairy air intake (6) enters inhaler, this effect of impact is further broken up drug particles; 6., the mode that still makes progress with symmetry in left passage (12) and right passage (13) of the mixture of drug particles of further being broken up and air-flow continues to advance, when the rear end that advances to central island (17) (15) when locating, just converge again and mixed at high speed, this intensive mixing effect of impact has also played the effect that the medicated powder granule is further broken up for the third time simultaneously, and finally breaks up the drug microparticles into suitable aerodynamic force size; 7., the drug microparticles with suitable aerodynamic force size enters patient's oral cavity with the upper channel (16) of air-flow in inhaler suction nozzle (4), and deposit to nasal cavity and bronchus, until the predetermined respiratory system position of pulmonary, tissue adherence by human body is absorbed, and reaches therapeutic purposes with this.
9. the described according to Claim 8 medicament delivery method that is used for the high-efficiency dry powder inhaler of drug conveying, it is characterized in that: described medicine bag (8) also can be substituted by cartridge case or recessed bubble, and described lower channel (10) front end that is used for the high-efficiency dry powder inhaler of drug conveying also can be provided with the fixedly auxiliary device of medicine bag, cartridge case or recessed bubble.
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| CN 201010210062 CN101856531A (en) | 2010-06-22 | 2010-06-22 | High-efficiency dry powder inhaler for medicament delivery and medicament delivery method thereof |
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| CN 201010210062 CN101856531A (en) | 2010-06-22 | 2010-06-22 | High-efficiency dry powder inhaler for medicament delivery and medicament delivery method thereof |
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| US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
| JP2018501903A (en) * | 2015-01-14 | 2018-01-25 | レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Powder dispersion method and apparatus |
| CN109475712A (en) * | 2016-07-04 | 2019-03-15 | 艾尔弗雷德.冯舒克曼 | Equipment for the output of substances that can be discharged through the air |
| CN109568742A (en) * | 2019-01-14 | 2019-04-05 | 苏州艾莱科劢德电子科技有限公司 | A kind of flow velocity arrangement for detecting of Diskus |
| CN110064110A (en) * | 2019-05-29 | 2019-07-30 | 上海理工大学 | A kind of volume knob dry powder storage suction apparatus |
| US10682476B2 (en) | 2012-02-21 | 2020-06-16 | Respira Therapeutics, Inc. | Powder inhaler, system and methods |
| WO2023011015A1 (en) * | 2021-08-03 | 2023-02-09 | 上海秀新臣邦医药科技有限公司 | Single-dose disposable powder aerosol inhalation device |
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| CN110064110A (en) * | 2019-05-29 | 2019-07-30 | 上海理工大学 | A kind of volume knob dry powder storage suction apparatus |
| WO2023011015A1 (en) * | 2021-08-03 | 2023-02-09 | 上海秀新臣邦医药科技有限公司 | Single-dose disposable powder aerosol inhalation device |
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