CN102119861B - Venous indwelling needle with hirudin anticoagulation pipe-sealing device - Google Patents
Venous indwelling needle with hirudin anticoagulation pipe-sealing device Download PDFInfo
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- CN102119861B CN102119861B CN201110027217A CN201110027217A CN102119861B CN 102119861 B CN102119861 B CN 102119861B CN 201110027217 A CN201110027217 A CN 201110027217A CN 201110027217 A CN201110027217 A CN 201110027217A CN 102119861 B CN102119861 B CN 102119861B
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Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a venous indwelling needle with a hirudin anticoagulation pipe-sealing device. The venous indwelling needle comprises a cannula which is led by a puncture needle and then inserted into a vein, a transparent tee joint which is connected with the rear end of the cannula and has a built-in isolating sealing plug, and a transfusion joint used for connecting a transfusion pipe or a blood-sampling pipe. The transparent tee joint is connected with the transfusion joint through an extension pipe. The transfusion joint is sealed by a sealing end cap. A crotch is formed on the end, which is connected with the extension pipe, of the transparent tee joint. The other end of the crotch is connected with a pipe-sealing device. The pipe-sealing device comprises a liquid-storing bag arranged in a support and a roller arranged between the two side walls of the support and used for pushing the liquid in the liquid-storing bag forward. By the invention, a pipe cavity of the indwelling needle can be filled with the pipe-sealing liquid. The pipe-sealing liquid in the pipe-sealing device can be hirudin diluent, which has good anticoagulant function and does not influence the indexes for the test of blood serum.
Description
Technical field
The invention belongs to technical field of medical instruments, particularly relate to a kind of venous detaining needle with hirudin anticoagulant blood pipe sealing device.
Background technology
In recent years, develop rapidly along with medical science applied, the venous detaining needle that can alleviate patient's repeated localised puncture misery has been widely used among the patient of critical patient's rescue transfusion, intravenous hyperalimentation and vein batch applications antibiotic or other medicines.Venous detaining needle comprises puncture needle and sleeve pipe.After the puncture needle band sleeve pipe and penetrated patient's vein, extract puncture needle, sleeve pipe stays in the body, and the outer end connects infusion set or blood-taking device again.Venous detaining needle not only can be used for conventional venous transfusion, and can be used for repeatedly taking a blood sample discontinuously, and the misery of both having avoided repeated localised puncture to cause to the patient has been protected patient's vein again, can also improve nurse's work efficiency simultaneously.
Because the sleeve pipe of venous detaining needle needs the long period to stay in the human vein, after each transfusion is finished, cause tube chamber to stop up for preventing that blood from refluxing to condense, all need to carry out tube sealing.Usually use common syringe that tube-sealing solution is injected now and carry out tube sealing in the remaining needle tube chamber." practical Chinese medicine magazine " 2010 the 26th 1 phases of volume, put down in writing in " application of venous detaining needle and nursing " literary composition that Zhang Jianrong, the Hou Sifang in the hospital of traditional Chinese hospital, Ninghe County, Tianjin delivers, the tube sealing maneuver is an important ring, usually adopt slowly injection malleation sealed-tube method, be that the limit is slowly injected the limit and withdrawed from syringe needle, guarantee that needle tip keeps malleation, avoid backflow of blood to the blood vessel pin, cause the blood coagulation plugging.Above-mentioned blood vessel pin promptly refers to the sleeve pipe of remaining needle.But this use ordinary syringe is carried out pipe sealing method, and to be the nurse push the dosage of tube-sealing solution according to oneself experience decision, the dosage control that does not have strict standard, be difficult to guarantee all to be full of tube-sealing solution in each remaining needle tube chamber, especially the sleeve pipe front end stretches into human body parts and is difficult to observe, if tube sealing does not thoroughly make backflow of blood to the sleeve pipe front end, caused the blood coagulation plugging not to be found again, agglomerative clot is poured in the human vein by liquid when infusing once more, can cause the generation of thrombosis.
" Chinese general family medicine " March in 2010, the 8th volume the 3rd phase 395-396 page or leaf was put down in writing heparin sodium diluent and normal saline that present clinical main tube-sealing solution commonly used is a variable concentrations in " effect of two kinds of tube sealing methods of venous detaining needle relatively ".Normal saline can prevent blood coagulation with the effect of keeping extracellular osmotic pressure, blood volume and water-electrolyte balance, blood circulation, and little to vascular stimulation, its malleation tube sealing is safe and reliable, and clinical practice is extensive than the heparin in sealing method.But the normal saline tube sealing time is shorter, and conventional normal saline needs 3-5 hour tube sealing once, has increased nurse's workload, also bothers patient and has a rest.And the normal saline tube sealing easily causes phlebitis, because normal saline using dosage once probably needs 10-30ml, and generally can only tube sealing 3-5h, the nursing staff need be through normal saline flushing pipeline commonly used, flushing line need puncture as the calparine cap of sealing end cap, because calparine cap just is easy to by germ contamination through repeatedly puncturing, flows into human body by transfusion and cause symptoms such as phlebitis.Part calparine cap poor quality is arranged in addition, and repeatedly puncture is passed through infusion pipeline with trickle medical grade rubber chip easily, directly enters human vas and causes bigger harm.
Therefore, clinically also often the result of use heparin sodium diluent that is better than normal saline carry out tube sealing.Heparin is a kind of acid mucopolysaccharide, all has stronger anticoagulation when using in vivo and in vitro, the dilution back is widely used in clinical as the remaining needle tube-sealing solution, use a small amount of Calciparine/sodium salt water sealing (sealing water) pipe, phlebitic incidence rate is starkly lower than the normal saline tube sealing, and tube sealing effect retention time is longer than the normal saline tube sealing.But the heparin sodium tube sealing still has inevitable shortcoming, because heparin sodium has certain side effect to cause anticoagulant easily, easily causes bleeding, dosage is difficult for shortcomings such as grasp, so for have, the patient of disturbances of blood coagulation, Ying Shenyong in order to avoid increase the weight of the state of an illness, adverse consequences occurs.The remaining needle operation of can drawing blood in addition avoids the patient by the misery of repeated localised puncture, but uses normal saline and the equal effect of heparin sodium undesirable.
The concrete condition of normal saline and heparin sodium is as follows:
Normal saline does not have pipe sealing effect or effect extreme difference for some especial patient.For example: high blood viscosity denseness patient, hyperlipidemia patient because self-blood compares thickness, are easy to stop up the situation of remaining needle.In case the situation that remaining needle blocks appears, the remaining needle that the nurse can only more renew usually, and puncture again causes patient's the financial burden that repetition is painful and increase is new, also influences nurse's work efficiency simultaneously.And the normal saline using dosage is big, easy dilute blood, and every index is on the low side when causing blood test, and in addition because the characteristics of normal saline make too early the condensing of blood easily, blood preparation can't carry out clinical blood count after solidifying and going bad.
Though heparin sodium has anticoagulation preferably, can remedy normal saline is applied on the especial patient, but heparin sodium has shortcoming of itself and very important limitation, shortcoming is an anticoagulant, shortcoming such as easily cause bleeding, dosage is difficult for grasp, thus for have, the patient of disturbances of blood coagulation, Ying Shenyong, in order to avoid increase the weight of the state of an illness, adverse consequences appears; Limitation shows as the experiment that can't detect projects such as hematology's routine blood test, whole blood test, hemorheology test, pharmacokinetic experiment, serum biochemistry, blood bank's test, blood sugar test, erythrocyte sedimentation rate experiment with the blood that contains heparin sodium, so the blood drawing of need puncturing again from other positions of patient during the above-mentioned project of general need check.In sum, as seen some especial patient promptly is not suitable for normal saline, also is not suitable for the heparin sodium tube sealing, but tube-sealing solution hirudin diluent provided by the invention just can solve the disadvantage of above-mentioned two kinds of traditional tube-sealing solutions.
The People's Republic of China's " Chinese pharmacopoeia version in 2010, first record " Hirudo (HIRUDO) ", this product is the dry all of Hirudinidae animal whitmania Whitmania pigra Whitman, Hirudo Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Whitmania wranulata Whitman, summer, Qiu Erji catch, scald extremely with boiling water, dry or the low humidity drying.Concoct: Hirudo is cleaned, cutting, drying.Scald Hirudo: get water purification trematodiasis section, water to little with Pulvis Talci according to the method for scalding and heave.Function with cure mainly: removing blood stasis, removing blood stasis stimulates the menstrual flow.Be used for the blood stasis amenorrhea, injury from falling down.
Foreign medical science blood transfusion and 1993 the 16th volumes of blood fascicle the 6th phase record Chinese Academy of Medical Sciences Blood Research Institute, Guo Juan summary Wang Hebi examines and revises " progress of lepirudin 023 ludon " Haycraft and found in the Hementaria officianalis extract anticoagulant substances is arranged in 1884.At the end of the fifties, Markwardt isolates pure product first, called after hirudin (Hirudin), and know that it is the special inhibitor of thrombin, be a kind of ideal anticoagulant, antithrombotic preparation.Learn its structure and amino acid sequence the beginning of the eighties.Loaded down with trivial details because of the natural hirudin extraction step, and raise the Hirudo difficulty, the Hirudo source is deficient, is difficult to obtain the pure product of q.s, and research and clinical practice are restricted.In recent years, the development of technique for gene engineering has remedied this defective, utilize chemosynthesis, cDNA library, PCR method to obtain gene clone, express and obtain lepirudin 023 ludon, thereby pharmacology, pharmacodynamics and the toxicity etc. of hirudin have more in depth been studied, a large amount of zooperies and clinic trial have been accelerated hirudin and have been applied to clinical process.
The structure of hirudin: natural hirudin is not contain polysaccharide, by the single chain protein that 65 or 66 amino acid residues are formed, and molecular weight about 7,000, be rich in dicarboxylic amino acid, no Arg, Met and Trp, there are three intramolecular disulfide bonds to be positioned at peptide chain N-end, molecular configuration is played Stabilization; The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged; The peptide chain middle part has one by Pro-Lys
47The special construction that-Pro forms, it plays a part certain in hirudin and thrombin interaction.
In 11 kinds of variants of hirudin, only variant I, II and III have anticoagulating active.
So far, all can obtain active lepirudin 023 ludon through escherichia coli or Yeast system expression, and be desulfurization acidic group hirudin, promptly 63 Tyr do not have sulphation.Reorganization has isomorphic map mutually with natural prodcuts.Further can produce multiple variant.
Along with the molecular biology develop rapidly, external at present existing tens companies develop lepirudin 023 ludon and the plain preparation of functional Hirudo, a large number of experiments show that recombinant products is similar to natural prodcuts, are effective anticoagulant and antithrombotic preparation.
The clinical indication of lepirudin 023 ludon can be summarized as follows: 1) surgery anticoagulant; 2) internal medicine anticoagulant; 3) adjuvant of thrombolytic drug; 4) anticoagulant of angioplasty; 5) anticoagulant etc. in the hemodialysis.On the experimentation basis, carrying out clinical bulge test (as subacute and chronic DIC) at present.
The architectural feature of hirudin:
The single chain protein that natural hirudin is made up of 65 amino acid residues, the about 7000D of molecular weight is rich in dicarboxylic amino acid, no Arg, Met, Trp, peptide chain N-end has 3 intramolecular disulfide bond (Cys6-Cys14; Cys16-Cys28; Cys22-Cys39), molecular configuration is played Stabilization.The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged, and is worked in the interaction of hirudin and thrombin by the special construction that a Pro-Lys47-Pro forms in the peptide chain middle part.
The chemical constitution of hirudin:
Hirudin on sale at present in market.
Summary of the invention
The present invention provides a kind of tube sealing effect that can guarantee in order to solve the variety of issue that exists in the prior art, can not need nurse's clinical manipulation easily to reach the pipe sealing purpose of malleation, need not the use amount that the nurse calculates tube-sealing solution, need not to screen patient's special circumstances selection tube-sealing solution, need not to prepare tube-sealing solution, need not the calparine cap of sterilizing before the use, can not enter blood, reduce the nurse job amount because of the calparine cap quality problems cause the medical grade rubber microgranule.Simple and safe operation, can also reduce patient's phlebitis risk, reduce malpractice, reduce doctor-patient dispute, stop because the improper need of tube sealing are changed the expense of remaining needle again, also have tube sealing time length and can artificially control the tube sealing time, do not influence the venous detaining needle with hirudin anticoagulant blood pipe sealing device of blood parameters again.
The technical scheme that the present invention takes for the technical problem that exists in the solution known technology is:
Venous detaining needle with hirudin anticoagulant blood pipe sealing device of the present invention comprises by the puncture needle guiding penetrating intravenous sleeve pipe, is connected the transparent threeway and the infusion connector that is used to be connected infusion pipeline or blood sampling pipeline of the built-in isolating seal plug of sleeve pipe rear end; Transparent threeway is connected with infusion connector by prolonging pipe, and infusion connector is by the sealing end caps; Transparent threeway forms bifurcated with prolonging the end that pipe is connected, and the other end of bifurcated connects pipe sealing device, and pipe sealing device comprises and is arranged on the interior liquid storing bag of support and is arranged on the roller that between the support two side liquid in the liquid storing bag is promoted forward.
Described pipe sealing device is connected with transparent threeway by connection tube; Form angle between an end that transparent threeway crotch is connected with the prolongation pipe and the end that is connected with connection tube less than 90 °.
The rear end of described connection tube forms the connecting portion that connects pipe sealing device, and the insertion section of pipe sealing device front end is connected in the connecting portion, and the rear end, insertion section is connected with liquid storing bag, and the inner cavity that forms in insertion section makes liquid storing bag and connection tube internal communication.
The compartment of terrain, wall upper end, the left and right sides of described support forms inclined-plane and depression, and the wheel shaft that roller central authorities are provided with is connected in the depression and along the inclined-plane and rolls forward.
The front end of described liquid storing bag stretches out from the front side wall of support, connects the insertion section; Stretch out from the rear wall of support the rear end of liquid storing bag, and the rear end is by the end cap sealing with sealing function.
The tube-sealing solution of splendid attire is the hirudin diluent in the described liquid storing bag.
The concentration of hirudin is 0.01mg/ml-50mg/ml in the described hirudin diluent.Preferred 0.01mg/ml-40mg/ml uses according to the about 1ml-15ml of different needs at every turn.
Described sleeve pipe is to adopt four polyvinyl fluoride materials to make, transparent threeway is to adopt medical material polythene material to make with the infusion connector that is used to be connected infusion pipeline or to take a blood sample pipeline, the puncture needle material is that medical stainless steel is made, the isolating seal plug is that medical butyl rubber plug is made, sealing end cap, roller, wheel shaft, end cap, liquid stopping block, hold needle handle, puncture needle handle, support are that medical plastic is made, liquid storing bag is made for the medical high polymer plastics.
Advantage and good effect that the present invention has are:
Venous detaining needle with hirudin anticoagulant blood pipe sealing device of the present invention is with pipe sealing device again on the venous detaining needle, need not to use in addition syringe, has saved resource, has made things convenient for nurse and patient's use simultaneously.Distance between per two depressions can guarantee that through calculating tube-sealing solution is full of the tube chamber of remaining needle, avoids backflow of blood and the blood coagulation plugging.Anticoagulant in the pipe sealing device is selected the hirudin diluent for use, compares with other tube-sealing solution, and hirudin has good anticoagulation, and is because dosage is small, without any side effects to human body.Pass through the careful required tube-sealing solution of calculating in addition and can guarantee that the hirudin diluent is full of need tube sealing place accurately, easily reach the pipe sealing effect of malleation, when the blood sampling check, can not influence the detection of anticoagulin in the blood again, suit repeatedly be used for tube sealing in discontinuity transfusion and the blood collection procedure.And the clinical manipulation that does not need the nurse easily reaches the pipe sealing purpose of malleation, need not the use amount that the nurse calculates tube-sealing solution, need not to screen patient's special circumstances selection tube-sealing solution, need not to prepare tube-sealing solution, need not the calparine cap of sterilizing before the use, can not enter blood, reduce the nurse job amount because of the calparine cap quality problems cause the medical grade rubber microgranule.Simple and safe operation can also reduce patient's phlebitis risk, reduces malpractice, reduces doctor-patient dispute, stops because the improper need of tube sealing are changed the expense of remaining needle again, also has tube sealing time length and can artificially control the tube sealing time.
Description of drawings
Fig. 1 is the structural representation with venous detaining needle of hirudin anticoagulant blood pipe sealing device of the present invention.
Critical piece symbol description in the accompanying drawing:
1: sleeve pipe 2: transparent threeway 3: isolating seal plug
4: prolong pipe 5: liquid stopping block 6: infusion connector
7: the first sealing end caps sealing in 8: the second end cap 9: connection tube
10: connecting portion 11: depression 12: inclined-plane
13: roller 14: wheel shaft 15: end cap
16: liquid storing bag 17: puncture needle 18: the puncture needle handle
19: hold needle handle 20: pipe sealing device 21: union joint
22: support
The specific embodiment
It is following that the present invention will be described in detail with reference to drawings and Examples.Parts same as the prior art have used identical symbol among the present invention.
Embodiment 1
Fig. 1 is the structural representation with venous detaining needle of hirudin anticoagulant blood pipe sealing device of the present invention.As shown in Figure 1, venous detaining needle with hirudin anticoagulant blood pipe sealing device of the present invention, comprise by puncture needle 17 guiding penetrating intravenous sleeve pipe 1, be connected the transparent threeway 2 and the infusion connector 6 that is used to be connected infusion pipeline or blood sampling pipeline of the built-in isolating seal plug 3 of sleeve pipe 1 rear end.
One end of transparent threeway 2 is connected with sleeve pipe 1, and an end is sealed by isolating seal plug 3, and the 3rd end is connected with infusion connector 6 by prolonging pipe 4.Prolong pipe 4 and be provided with liquid stopping block 5.Sleeve pipe 1 is socketed in outside the puncture needle 17, and stretch out from the front end of sleeve pipe 1 at the tip of puncture needle 17.The rear end of puncture needle 17 is provided with puncture needle handle 18, after sleeve pipe 1 enters vein for convenience, puncture needle 17 is extracted, and a side of puncture needle handle 18 is provided with holds needle handle 19.
Infusion connector 6 can adopt single lumen catheter, also can adopt double lumen tube.If the employing single lumen catheter, the free end of single lumen catheter is by the sealing end caps; If the employing double lumen tube, two kinds of different medicines of infusion simultaneously, the two ends of double lumen tube are respectively by the first sealing end cap 7 and second sealing end cap 8 (the being commonly called as calparine cap) sealing.
Transparent threeway 2 forms bifurcateds with the ends that prolongation pipe 4 is connected, and the other end of bifurcated connects the connection tube 9 that is connected with pipe sealing device 20.Transparent threeway crotch with prolong pipe 4 ends that are connected and with a end that connection tube 9 is connected between formation less than 90 ° angle.The rear end of connection tube 9 forms the connecting portion 10 that is connected with pipe sealing device 20.Pipe sealing device 20 comprises and is arranged on the liquid storing bag 16 in the support 22 and is arranged on the roller 13 that between support 22 two sides liquid in the liquid storing bag is promoted forward.The insertion section 21 of pipe sealing device 20 front ends is connected in the connecting portion 10, and 21 rear ends, insertion section are connected with liquid storing bag 16, and the insertion section 21 inner cavitys that form make liquid storing bag 16 and connection tube 9 internal communication.
The compartment of terrain, wall upper end, the left and right sides of support 22 forms inclined-plane 12 and caves in 11, and the wheel shafts 14 that roller 13 central authorities are provided with are connected in the depression 11 and 12 rollings forward along the inclined-plane.The front end of liquid storing bag 16 stretches out from the front side wall of support 22, connects insertion section 21; Stretch out from the rear wall of support 22 rear end of liquid storing bag 16, and the rear end is by end cap 15 sealings with sealing function.
Sleeve pipe 1 is to adopt four polyvinyl fluoride materials to make, transparent threeway 2 is to adopt medical material polythene material to make with the infusion connector 6 that is used to be connected infusion pipeline or to take a blood sample pipeline, puncture needle 17 materials are that medical stainless steel is made, isolating seal plug 3 is made for medical butyl rubber plug, sealing end cap 7,8, roller 13, wheel shaft 14, end cap 15, liquid stopping block 5, hold needle handle 19, puncture needle handle 18, support 22 are made for medical plastic, liquid storing bag 16 is made for the medical high polymer plastics.
The tube-sealing solution of splendid attire is the hirudin diluent in the above-mentioned liquid storing bag 16.The concentration of hirudin is 0.01mg/ml-50mg/ml in the hirudin diluent.Use according to the about 1ml-15ml of different needs at every turn.The concentration of hirudin can be selected 0.1mg/ml, 1mg/ml, 8mg/ml or 35mg/ml for use as required.
Embodiment 2
Comparative experiments
Hirudin concentration is: 0.01mg/ml～50mg/ml uses according to the about 1ml-15ml of different needs at every turn.
The relation of hirudin and thrombin is as follows:
The first, lepirudin 023 ludon and α-thrombin with etc. mole non-covalent combine form stabilized complex (its dissociation constant is very little, 0.8 * 10
-10Mol or 2.0 * 10
-14Mol).The whole protease hydrolysis functions of thrombin this moment are closed, so hirudin can not only prevent fibrinogenic consolidation, and the hemostasis that can block catalyzed by thrombin is reacted, the platelet response that brings out such as the activation and the thrombin of factor V, VIII and III, the thrombin that has prevented the activatory feedback of thrombinogen and caused generates, hirudin does not disturb the biosynthesis of thrombin simultaneously, and antithrombin (AT-III) is not also had influence.
The second, oxidized when hirudin, disulfide bond, or its C-end is shown that by depsipeptides (the C-end reduces by 7 or 22 aminoacid then to the inhibition loss of activity 90% or 100% of thrombin) hirudin is a reversibility to the inhibitory action of thrombin.
Hirudin has following characteristics in actual applications:
The first, the agent of gene recombinaton hirudin anticoagulant does not contain heavy metal ion, does not have Sulfated pure biological preparation, and is noiseless to test item, is applicable to detections such as biochemistry, immunology, hematology.Also be applicable to unit blood specimen collections such as medical research mechanism, blood station, health and epidemic prevention.
The second, the Tyr peptide chain structure of hirudin can suppress the thrombin specificity, but this effect is reversible, and when the reaction of Tyr peptide chain warp depsipeptides, after the hirudin forfeiture suppressed activity, blood preparation also can be done hemagglutination test again.
The 3rd, haemachrome hematocrit and leukocyte etc. all there are not influence, can not only be used for the research of Physiological Experiment and clotting mechanism, and on clinical medicine, also can be used as the anticoagulant when transfusing blood.
The 4th, can reduce surface activity of blood platelet to platelet, anticoagulant reduces platelet adhesion.Hirudin can suppress the adhesive attraction of platelet to silication glass, and this is not direct interaction to hematoblastic effect, and it does not disturb hematoblastic function.
The 5th, the blood coagulation resisting function of hirudin in different animals and blood plasma its anticoagulation that confirms different with heparin, it does not rely on anticoagulant factor, does not disturb the detection of anticoagulant factor yet, is not subjected to influence of platelet CA++ (PF4) and rich histidine protein or the like yet.It is safe, the most effective antithrombase anticoagulant in the known anticoagulative substance in the present world.
Claims (8)
1. venous detaining needle with hirudin anticoagulant blood pipe sealing device, comprise by puncture needle (17) guiding penetrating intravenous sleeve pipe (1), be connected the transparent threeway (2) and the infusion connector (6) that is used to be connected infusion pipeline or blood sampling pipeline of the built-in isolating seal plug (3) of sleeve pipe rear end; Transparent threeway (2) is connected with infusion connector (6) by prolonging pipe (4), and infusion connector is by the sealing end caps; It is characterized in that: the end that transparent threeway (2) is connected with prolongation pipe (4) forms bifurcated, the other end of bifurcated connects pipe sealing device (20), and pipe sealing device (20) comprises and is arranged on the liquid storing bag (16) in the support (22) and is arranged on the roller (13) that liquid between support (22) two side that liquid storing bag (16) is interior promotes forward.
2. the venous detaining needle with hirudin anticoagulant blood pipe sealing device according to claim 1 is characterized in that: pipe sealing device (20) is connected with transparent threeway (2) by connection tube (9); Transparent threeway crotch with prolong a end that pipe (4) is connected and with a end that connection tube (9) is connected between formation less than the angle of 90o.
3. the venous detaining needle with hirudin anticoagulant blood pipe sealing device according to claim 2, it is characterized in that: the rear end of connection tube (9) forms the connecting portion (10) that connects pipe sealing device, the insertion section (21) of pipe sealing device (20) front end is connected in the connecting portion (10), rear end, insertion section (21) is connected with liquid storing bag (16), the inner cavity that forms in insertion section (21) makes liquid storing bag and connection tube internal communication.
4. the venous detaining needle with hirudin anticoagulant blood pipe sealing device according to claim 2, it is characterized in that: the compartment of terrain, left and right sides wall upper end of support (22) forms inclined-plane (12) and depression (11), the wheel shaft (14) that roller (13) central authorities are provided be connected depression (11) interior and along the inclined-plane (12) roll forward.
5. the venous detaining needle with hirudin anticoagulant blood pipe sealing device according to claim 2 is characterized in that: the front end of liquid storing bag (16) stretches out from the front side wall of support (22), connects insertion section (21); Stretch out from the rear wall of support (22) rear end of liquid storing bag (16), and the rear end is sealed by the end cap with sealing function (15).
6. the venous detaining needle with hirudin anticoagulant blood pipe sealing device according to claim 2 is characterized in that: the tube-sealing solution of the interior splendid attire of liquid storing bag (16) is the hirudin diluent.
7. the venous detaining needle with hirudin anticoagulant blood pipe sealing device according to claim 6 is characterized in that: the concentration of hirudin is 0.01mg/ml-50mg/ml in the hirudin diluent.
8. the hirudin anticoagulant blood tube sealing external member of venous detaining needle according to claim 4, it is characterized in that: sleeve pipe (1) adopts four polyvinyl fluoride materials to make, transparent threeway (2) adopts medical material polythene material to make with the infusion connector (6) that is used to be connected infusion pipeline or to take a blood sample pipeline, puncture needle (17) adopts medical stainless steel to make, isolating seal plug (3), sealing-plug (10) is made for medical butyl rubber plug, sealing end cap (7,8), roller (13), wheel shaft (14), support (22) is made for medical plastic, and liquid storing bag (16) is made for the medical high polymer plastics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110027217A CN102119861B (en) | 2011-01-26 | 2011-01-26 | Venous indwelling needle with hirudin anticoagulation pipe-sealing device |
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|---|---|---|---|
| CN201110027217A CN102119861B (en) | 2011-01-26 | 2011-01-26 | Venous indwelling needle with hirudin anticoagulation pipe-sealing device |
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| CN102119861B true CN102119861B (en) | 2011-12-28 |
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| CN105879151A (en) * | 2014-08-21 | 2016-08-24 | 陈艳玲 | Fixed handle storage seal liquid type non-backflow disposal vein remaining needle |
| CN110473442B (en) * | 2019-08-01 | 2024-07-09 | 江苏省中医院 | Vein indwelling needle tube sealing operation training device |
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| US20030163096A1 (en) * | 2002-02-28 | 2003-08-28 | Becton, Dickinson And Company | Shieldable fluid collection set |
| CN1569268A (en) * | 2003-07-11 | 2005-01-26 | 上海康德莱企业发展集团有限公司 | Safety indwelled needle with wings for venous transfusion |
| TWI308874B (en) * | 2004-02-26 | 2009-04-21 | Nipro Corp | Safe indwelling needle |
| WO2006027923A1 (en) * | 2004-09-03 | 2006-03-16 | Terumo Kabushiki Kaisha | Indwelling needle assembly |
| CN201001901Y (en) * | 2006-08-08 | 2008-01-09 | 上海林华医疗器械有限公司 | Positive pressure needle-free connecting type indwelling needle |
| US20090036841A1 (en) * | 2007-08-01 | 2009-02-05 | Mckale James M | Coatings for blood and bone marrow-contacting devices |
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