CN102218182B - Vibrating dosing device for dry power dosing device - Google Patents
Vibrating dosing device for dry power dosing device Download PDFInfo
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- CN102218182B CN102218182B CN201110156770.1A CN201110156770A CN102218182B CN 102218182 B CN102218182 B CN 102218182B CN 201110156770 A CN201110156770 A CN 201110156770A CN 102218182 B CN102218182 B CN 102218182B
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- 239000002775 capsule Substances 0.000 claims description 51
- 238000001647 drug administration Methods 0.000 claims description 14
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- 238000007596 consolidation process Methods 0.000 claims description 3
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- 208000006673 asthma Diseases 0.000 description 2
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- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a vibrating dosing device for a dry power dosing device, which belongs to the field of apparatuses for inputting media into human bodies. The vibrating dosing device comprises a shell, a medicine powder storage container, a dosing measurement component and a runner part. The runner part is connected with an air inlet, the dosing measurement component and a suction nozzle in sequence. The vibrating feeding device is characterized in that the inverted-conical medicine powder storage container is arranged at the upper part of the shell; the dosing measurement component comprising a central rotating shaft and a quantitative dosing plate is arranged below the inverted-conical medicine powder storage container; a convex vibrating tooth is arranged at an outlet of the inverted-conical medicine powder storage container; a circle of convex teeth is arranged on the vertical height position of the central rotating shaft, corresponding with the vibrating tooth; and the vibrating tooth is matched with the convex teeth to form a vibrating component which can lead the outlet of the inverted-conical medicine powder storage container to generate vibration. As a vibrating tooth-convex tooth vibrating way is adopted, the vibrating dosing device is unrelated with an elastic part, and is not influenced by the change of the storage amount of medicine powder, thus guaranteeing the accurate dosing measurement. The vibrating feeding device can be applicable to the field for designing and manufacturing dry powder suction type dosing devices of various specifications.
Description
Technical field
The invention belongs to the instrument field inputted by medium in human body, particularly relating to a kind of inhalation-type drug administration apparatus for the powdered medicine of prescribed dose being sent into patient oral cavity.
Background technology
In modern medical service technology, generally include oral to the route of administration of patient, suck, sublingual administration, external application, rectally, several administering modes such as injection.
Because direct oral cavity or snuffing enter to make medicine directly to enter blood by the mucosa absorption of oral cavity or nose, " head crosses " effect of liver can be walked around, therefore for the treatment/administration of numerous disease (modal is exactly asthma), the administering mode of fast onset first elects the administering mode that direct oral cavity (or nose) sucks.
Existingly be used for the treatment of the respiratory tract diseases such as asthma, device through inhalation mode, mainly contain aerosol drug delivery device and the large class of dry powder inbalation administration device two.
For aerosol drug delivery device, along with the raising of home and abroad environmental consciousness, fluoric ether (CFC, chlorofluorocarbon) class aerosol is eliminated (Chlorofluorocarbons (CFCs) gradually, it is one group of alkyl halide be made up of chlorine, fluorine and carbon, be used by people to do refrigerator refrigerant at first, but because it can play decomposition to ozone layer, from 1 day January in 1996, Chlorofluorocarbons (CFCs) is formally prohibited to produce), during new comparatively ideal aerosol is studied further.
On the other hand, if use aerosol type doser, patient must can coordinate " spraying " and the rhythm of " suction " two actions preferably, just can reach comparatively ideal medicine and suck effect.
And the operation of dry powder inhalant doser, then the complete active consciousness by patient determines, does not have the problem that " injection " and " suction " are coordinated.
For dry powder inhalant doser, divide from the angle of medicament storage, be mainly divided into two large classes at present: barrier packaging formula and reservoir type.
1) barrier packaging formula dry powder inhalant doser:
Device product is received for commercially available " fluticasone propionate " standard, its concrete structure is on May 2nd, 2007 in the day for announcing, Authorization Notice No. is existing in the Chinese invention patent of CN 1313171C description, this publication disclose one " inhaler ", this inhaler has multiple chamber separating into array, and each chamber comprises the medicine of dosing; And moving chamber one by one with the lever aimed at the inlet hole being formed the mouth of pipe, each chamber comprises inward flange and outward flange, and multiple chamber is closed by sealant.This inhaler also have sealant is lifted away from chamber inward flange and outward flange to open the mechanism of the air duct be made up of this chamber and sealant.Therefore, in use, when by this mouth of pipe air-breathing, the airflow entrainment in air flow passage the medicated powder in chamber, is evacuated to outside inhaler by this mouth of pipe by air.
Find in actual use, the volume of this type of dry powder inhalant doser is usually comparatively large, makes the manufacture/acquisition cost of whole suction apparatus also relatively high.
2) reservoir dry powder suction type medicator:
Authorized announcement date is on July 12nd, 2000, Authorization Notice No. is in the Chinese invention patent of CN 1054304C, disclose one " medicament dispensing device ", this device has dust container, the air of a constant volume, the measuring room be communicated with dust container that can load a kind of efflorescence medicament, and this measuring room graded separates efflorescence medicament quantitatively from container.
Authorized announcement date is on March 29th, 2006, Authorization Notice No. is in the Chinese invention patent of CN 1247275C, disclose one " inhalation apparatus ", it comprises: a flow channel, formed by multiple surface, user makes the air draught of the powder carrying described dosage by this passage by air-breathing; A metering units, for the powder of doses is provided to described flow channel, to take powder by air draught.
Visible, this type of reservoir dry powder suction type medicator is all provided with a dust container and corresponding metering element usually, separates efflorescence medicament quantitatively by metering element gradation from dust container.
Dry/problem that micropowder administration one is larger is that powdery granule has larger surface energy, easily forms " reunions " state, thus causes larger difficulty to the metering of the every dose of depot medicine.
On head it off, existing many research worker have done a lot of trials, as in Chinese invention patent ZL91107979.3, the powder of drug-reservoir are applied with to the pressure of a spring, to attempt the problem solving accurate measurement.But the power of spring changes along with length, its structures shape this device " residual powder " is more, and easily leaks powder, cannot avoid the maloperation of overdose administration simultaneously.
Also there is the problem being difficult to accurate-metering when dry powder is less in the medication dosing mode in Chinese invention patent application 200780008580.7.
Publication number is that the international patent application of WO2008/001744 adds one " vibration unit " at the housing of doser, it is by producing vibration during device for opening upper cover, wish to make medicated powder enter into measurement structure better, but to medicated powder, measurement structure is entered to the vibration of doser entirety and has much contributions, also more difficult judge.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of vibrating dosing device of dry powder drug administration device, and it adopts and arranges vibration administration unit in the outlet of powder bank, and achieving can the function of accurate-metering medicated powder dosage, and avoids the danger of super metering administration.
Technical scheme of the present invention is: the vibrating dosing device providing a kind of dry powder drug administration device, comprise and combine by upper main component and lower main component the housing formed, be provided with medicated powder storage capsule and administration gauge assembly in the housing, at the arranged outside suction nozzle of housing, arrange flow path features in the inside of housing, flow path features successively gas circuit connects air inlet, administration gauge assembly and suction nozzle; It is characterized in that: on the top of housing, the described medicated powder storage capsule of inverted cone shape is set; In the upper periphery of housing, a ring-type manual rotation portion is set; In the below of the described medicated powder storage capsule of inverted cone shape, the administration gauge assembly comprising central rotating shaft and dosed administration dish is set; The central rotating shaft of described administration gauge assembly is connected with described ring-type manual rotation portion; In the outlet of the described medicated powder storage capsule of inverted cone shape, the vibration tooth of a projection is set; On central rotating shaft, on the vertical height position corresponding with vibration tooth, a circle raised tooth is set; Described vibration tooth coordinates with raised tooth, forms one and the described medicated powder storage capsule of inverted cone shape can be made to export vibrative vibration component.
When described central rotating shaft rotates under the drive in ring-type manual rotation portion, described vibration component makes the outlet of the described medicated powder storage capsule of inverted cone shape produce vibration; In described central rotating shaft rotary course, the vibration tooth of described vibration component and raised tooth are ceaselessly collided, because the outlet consolidation of the described medicated powder storage capsule vibrating tooth and inverted cone shape is integrated, then the outlet of the described medicated powder storage capsule of inverted cone shape also synchronously produces vibration, reach knock inverted cone shape described medicated powder storage capsule medicine outlet, realize vibration administration, that medicated powder is flowed is smooth, the functional effect of dosage accurate measurement.
Described vibrating dosing device, by arranging the described medicated powder storage capsule of inverted cone shape and arranging vibration administration unit in the outlet of the described medicated powder storage capsule of inverted cone shape, ensure that the accurate measurement of dosage, and adopt the mode of vibration of vibration tooth-raised tooth, have nothing to do with elastomeric element, not by the impact of medicated powder storage capacity change.
Further, in the one side of described dosed administration dish towards the described medicated powder storage capsule outlet of inverted cone shape, arrange three administration grooves, described administration groove is uniformly distributed along the circumference on dosed administration dish.
It, on the top of described housing, arranges dry component, and described dry component becomes 120 degree of angles to arrange with the described medicated powder storage capsule of inverted cone shape relative to longitudinal center's axis of housing.
Concrete, the outlet of the described medicated powder storage capsule of the dry component described in it and inverted cone shape be arranged on concentric, with Radius level circumferentially.
The outlet of the described medicated powder storage capsule of dry component described in it or inverted cone shape, with the circumferential spread concentric at three administration groove places, is arranged with radius ground is corresponding.
A circle raised tooth described in it and the central rotating shaft of administration gauge assembly or dosed administration dish fix as one.
Compared with the prior art, advantage of the present invention is:
1. inverted cone shape medicated powder storage capsule is set and vibration administration unit is set in the outlet of inverted cone shape medicated powder storage capsule, ensure that the accurate measurement of dosage;
2. adopt the mode of vibration of vibration tooth-raised tooth, have nothing to do with elastomeric element, not by the impact of medicated powder storage capacity change;
3., by arranging dry component, before adding medicated powder at every turn, drying being carried out to medicated powder measurement structure/assembly, further ensures the accurate of dosage.
Accompanying drawing explanation
Fig. 1 is the stereo decomposing structural representation of dry powder drug administration device;
Fig. 2 is the medicated powder storage capsule structural representation of dry component and inverted cone shape;
Fig. 3 is the structural representation of vibration administration unit;
Fig. 4 is the structural representation of vibration component.
Rotating shaft centered by 1 in figure, the axis hole of rotating shaft centered by 1-1,8 is upper main component, and 10 is flow path features, 11 is suction nozzle, and 13 is dosed administration dish, and 14 is administration groove, and 16 is lower main component, 17 is drying tube, and 19 is vibration tooth, and 20 is the medicated powder storage capsule of inverted cone shape, and 29 is raised tooth.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention will be further described.
In Fig. 1, this dry powder drug administration device arranges one and combines by upper main component 8 and lower main component 16 housing formed; In the outside of housing, suction nozzle 11 is set, on the top of housing, the medicated powder storage capsule (not shown) of inverted cone shape is set; In the upper periphery of housing, a ring-type manual rotation portion (not shown) is set; In the below of the medicated powder storage capsule of inverted cone shape, the administration gauge assembly comprising central rotating shaft 1 and dosed administration dish 13 is set; The central rotating shaft of described administration gauge assembly is connected with ring-type manual rotation portion; In the inside of housing, flow path features 10 is set; Described flow path features successively gas circuit connects air inlet (not shown), administration gauge assembly and suction nozzle.
Described dosed administration dish arranges administration groove 14, and described administration groove is uniformly distributed along the circumference setting, and the outlet of the medicated powder storage capsule of described administration groove and dry component and inverted cone shape is arranged on the level of same Radius circumferentially accordingly; In other words, the outlet of the medicated powder storage capsule of described dry component or inverted cone shape, correspondingly with the horizontal distribution circumference at three administration groove places is arranged.
The outlet bottom surface of the medicated powder storage capsule of administration groove and inverted cone shape is close to; Medicated powder flows into the administration groove of dosed administration dish from the medicated powder storage capsule of inverted cone shape, fills to be patient and once to suck dosage (in the industry referred to as " dosage ") needed for medicament.
Because administration groove is not through hole, so when center axis of rotation drives dosed administration dish to rotate, implement, in the process of administration, just to avoid the problem of " overdose " administration, reach the object of accurate-metering.
In Fig. 2, on the top of housing, medicated powder storage capsule 20 and the dry component 17 of inverted cone shape is set.
Described dry component becomes 120 degree of angles to arrange with the center (centrage of the axis hole 1-1 with central shaft in figure represents longitudinal center's axis) of the relative housing of medicated powder storage capsule of inverted cone shape.
The outlet of the medicated powder storage capsule of described dry component and inverted cone shape is arranged on the level of same Radius circumferentially.
When administration groove arrives dry component outlet below, because dry component is built with adsorption dessicant, so administration groove will obtain drying.
In Fig. 3, in the outlet of the medicated powder storage capsule 20 of inverted cone shape, the vibration tooth 19 of a projection is set.
On central rotating shaft, on the position corresponding with vibration tooth level height, be provided with a circle raised tooth 29.
In Fig. 4, in the outlet of the medicated powder storage capsule 20 of inverted cone shape, be provided with vibration tooth 19, on the vertical height that central rotating shaft is corresponding, be provided with a circle raised tooth 29 accordingly.
Described vibration tooth coordinates with raised tooth, forms one and the medicated powder storage capsule of inverted cone shape can be made to export vibrative vibration component.
When center axis of rotation, one circle raised tooth is synchronously rotated, the collision between tooth and tooth is produced successively between each raised tooth and vibration tooth, because the outlet consolidation of the medicated powder storage capsule vibrating tooth and inverted cone shape is integrated, then the outlet of the medicated powder storage capsule of inverted cone shape also synchronously produces vibration, thus achieves the purpose of design of vibration administration.
During actual use operation, user, by rotary annular manual rotation portion, makes central rotating shaft rotate, and then drives dosed administration dish to rotate.
A patient inhales the process of medicated powder, and dosed administration dish rotates 120 °, rotates with this regular cycles, the process that each administration groove part experiences successively " drying, powder charge powder, medicated powder are sucked out ".
In central rotating shaft rotary course, the vibration tooth of vibration component and raised tooth are ceaselessly collided, reach knock inverted cone shape medicated powder storage capsule medicine outlet, that medicated powder is flowed is smooth, the functional effect of dosage accurate measurement.
So circulate successively, in constantly using afterwards, three little grooves directional-rotation always of quantitative disk, is ceaselessly in " powder charge, wait to inhale, dry " such cyclic process.
About other parts in this doser, comprise the operating process etc. of component and function thereof, whole dry powder drug administration device, can related content in REFERENCE TO RELATED people and the application " a kind of dry powder drug administration device " applied on the same day, no longer describe at this.
Adopt the medicated powder storage capsule of inverted cone shape due to the technical program and vibration administration unit is set in the outlet of the medicated powder storage capsule of inverted cone shape, ensure that the accurate measurement of dosage.
, due to the mode of vibration that it adopts vibration tooth-raised tooth, have nothing to do with elastomeric element, not by the impact of medicated powder storage capacity change meanwhile.
In addition, the technical program, by arranging dry component, adding medicated powder before at every turn, is carried out drying to medicated powder measurement structure/assembly, is further ensured the accurate of dosage, and avoid the danger of " overdose " administration.
The technical program is applicable to design, the manufacture field of the dry powder inhalant doser of all size.
Claims (6)
1. the vibrating dosing device of a dry powder drug administration device, comprise and combine by upper main component and lower main component the housing formed, be provided with medicated powder storage capsule and administration gauge assembly in the housing, at the arranged outside suction nozzle of housing, arrange flow path features in the inside of housing, flow path features successively gas circuit connects air inlet, administration gauge assembly and suction nozzle; It is characterized in that:
On the top of housing, the described medicated powder storage capsule of inverted cone shape is set;
In the upper periphery of housing, a ring-type manual rotation portion is set;
In the below of the described medicated powder storage capsule of inverted cone shape, the administration gauge assembly comprising central rotating shaft and dosed administration dish is set;
The central rotating shaft of described administration gauge assembly is connected with described ring-type manual rotation portion;
In the outlet of the described medicated powder storage capsule of inverted cone shape, the vibration tooth of a projection is set;
On central rotating shaft, on the vertical height position corresponding with vibration tooth, a circle raised tooth is set;
Described vibration tooth coordinates with raised tooth, forms one and the described medicated powder storage capsule of inverted cone shape can be made to export vibrative vibration component;
When described central rotating shaft rotates under the drive in ring-type manual rotation portion, described vibration component makes the outlet of the described medicated powder storage capsule of inverted cone shape produce vibration;
In described central rotating shaft rotary course, the vibration tooth of described vibration component and raised tooth are ceaselessly collided, because the outlet consolidation of the described medicated powder storage capsule vibrating tooth and inverted cone shape is integrated, then the outlet of the described medicated powder storage capsule of inverted cone shape also synchronously produces vibration, reach knock inverted cone shape described medicated powder storage capsule medicine outlet, realize vibration administration, that medicated powder is flowed is smooth, the functional effect of dosage accurate measurement;
Described vibrating dosing device, by arranging the described medicated powder storage capsule of inverted cone shape and arranging vibration administration unit in the outlet of the described medicated powder storage capsule of inverted cone shape, ensure that the accurate measurement of dosage, and adopt the mode of vibration of vibration tooth-raised tooth, have nothing to do with elastomeric element, not by the impact of medicated powder storage capacity change.
2. according to the vibrating dosing device of dry powder drug administration device according to claim 1, it is characterized in that in the one side of described dosed administration dish towards the described medicated powder storage capsule outlet of inverted cone shape, arrange three administration grooves, described administration groove is uniformly distributed along the circumference on dosed administration dish.
3. according to the vibrating dosing device of dry powder drug administration device according to claim 1, it is characterized in that the top at described housing, arrange dry component, described dry component becomes 120 degree of angles to arrange with the described medicated powder storage capsule of inverted cone shape relative to longitudinal center's axis of housing.
4. according to the vibrating dosing device of dry powder drug administration device according to claim 3, it is characterized in that the outlet of the described medicated powder storage capsule of described dry component and inverted cone shape be arranged on concentric, with Radius level circumferentially.
5. according to the vibrating dosing device of dry powder drug administration device according to claim 3, it is characterized in that the outlet of the described medicated powder storage capsule of described dry component or inverted cone shape, with the circumferential spread concentric at three administration groove places, arrange with radius ground is corresponding.
6., according to the vibrating dosing device of dry powder drug administration device according to claim 1, it is characterized in that the central rotating shaft of a described circle raised tooth and administration gauge assembly or dosed administration dish fix as one.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110156770.1A CN102218182B (en) | 2011-06-13 | 2011-06-13 | Vibrating dosing device for dry power dosing device |
| PCT/CN2012/076647 WO2012171443A1 (en) | 2011-06-13 | 2012-06-08 | Dry powder drug administration device |
| US14/125,936 US9750901B2 (en) | 2011-06-13 | 2012-06-08 | Dry powder drug-dosing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110156770.1A CN102218182B (en) | 2011-06-13 | 2011-06-13 | Vibrating dosing device for dry power dosing device |
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| Publication Number | Publication Date |
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| CN102218182A CN102218182A (en) | 2011-10-19 |
| CN102218182B true CN102218182B (en) | 2015-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110156770.1A Active CN102218182B (en) | 2011-06-13 | 2011-06-13 | Vibrating dosing device for dry power dosing device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012171443A1 (en) * | 2011-06-13 | 2012-12-20 | 上海秀新臣邦医药科技有限公司 | Dry powder drug administration device |
| CN103656811B (en) * | 2012-09-19 | 2015-06-17 | 上海理工大学 | Powder dosing device |
| AT513810B1 (en) * | 2012-12-18 | 2015-02-15 | Harald Ing Rauchenschwandtner | A method and apparatus for deploying aqueous polymer-containing biocides in space by ultrasonic technology |
| TWI555578B (en) * | 2015-01-20 | 2016-11-01 | Kuan-Jung Chung | Extraction of quantitative dosages |
| CN104971411B (en) * | 2015-06-30 | 2023-08-29 | 上海臣邦医药科技股份有限公司 | Powder fog agent dosing device |
| CN104971415B (en) * | 2015-06-30 | 2020-06-26 | 上海臣邦医药科技股份有限公司 | Double-vibration medicine storage unit of powder inhalation administration device |
| CN105031782B (en) * | 2015-06-30 | 2020-06-26 | 上海臣邦医药科技股份有限公司 | Method for improving dosing quantity metering accuracy of powder inhalation dosing device |
| CN104971412B (en) * | 2015-06-30 | 2020-06-26 | 上海臣邦医药科技股份有限公司 | Vibration medicine storage unit of powder inhalation dosing device |
| CN104971413B (en) * | 2015-06-30 | 2023-04-14 | 上海臣邦医药科技股份有限公司 | Anti-misoperation unit and anti-misoperation method of powder aerosol dosing device |
| CN105031781B (en) * | 2015-06-30 | 2020-08-07 | 上海臣邦医药科技股份有限公司 | Method for controlling accuracy of medicine supply quantity of powder aerosol dosing device |
| CN105363103A (en) * | 2015-12-07 | 2016-03-02 | 江苏知原药业有限公司 | Powder quantitative counting medicine bottle |
| CN105413029B (en) * | 2016-01-09 | 2018-07-13 | 陈晓阳 | Quantitative powder drug form suction apparatus |
| CN115970104B (en) * | 2022-12-09 | 2024-09-13 | 中国药科大学 | Novel reservoir type dry powder inhaler |
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| CN102218182A (en) | 2011-10-19 |
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Effective date of registration: 20231225 Address after: No. 1633 Selling New Highway, Xinqiao Town, Songjiang District, Shanghai, 201612 Patentee after: SHANGHAI XINHUANGHE PHARMACEUTICAL CO.,LTD. Address before: Room 213, Building 2, No. 563 Songtao Road, Zhangjiang High tech Park, Pudong New Area, Shanghai, March 2012 Patentee before: SHANGHAI XIUXIN CHENPON PHARMACEUTICAL TECHNOLOGY Co.,Ltd. |