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CN102269768B - Cleaning swab and application thereof to haemal cell analyzer - Google Patents

Cleaning swab and application thereof to haemal cell analyzer Download PDF

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Publication number
CN102269768B
CN102269768B CN 201010619701 CN201010619701A CN102269768B CN 102269768 B CN102269768 B CN 102269768B CN 201010619701 CN201010619701 CN 201010619701 CN 201010619701 A CN201010619701 A CN 201010619701A CN 102269768 B CN102269768 B CN 102269768B
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cleaning
test tube
swab
line segment
axle
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CN102269768A (en
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滕锦
刘治志
祁昌春
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Abstract

The invention discloses a cleaning swab and application thereof to a haemal cell analyzer. The cleaning swab comprises a main body, wherein the main body has a first surface and a second surface; a centering hole is formed from the first surface to the second surface, is enclosed by a peripheral wall surface and a bottom surface, and penetrates the bottom surface and the second surface to form a puncture channel; the puncture channel is provided with a puncture hole and a cleaning cavity, which are communicated with each other; the main body is provided with a liquid inlet interface and a liquid outlet interface which are communicated with the cleaning cavity; the puncture hole has an axis; the peripheral wall surface comprises a guide surface connected with the bottom surface; the guide surface and the bottom surface are respectively intersected with a plane passing through the axis to form a first line segment and a second line segment; and the first line segment has a slope relative to the second line segment, so that a test tube can slide along the guide surface to the bottom surface. The cleaning swab can simultaneously meet puncture requirements of a common test tube and an injection test tube in a common-precision automatic sampling system, the cost is reduced, and the operation is simple.

Description

Clean swab and the application on blood cell analyzer thereof
Technical field
The invention relates to a kind of cleaning swab.
Background technology
Be accompanied by the doctor to saving time of proposing of cellanalyzer, laborsaving, safe demand, from then on the auto injection tally function is born.How to guarantee that auto injection can support common test tube (as shown in Figure 1) and injecting type test tube (as shown in Figure 2) simultaneously, become a new demand of cellanalyzer manufacturer.
The regional a that punctures of common test tube different with the regional b of puncturing of injecting type test tube (the punctured zone of injecting type test tube is littler than common test tube), therefore the cellanalyzer auto injection will satisfy the demand of supporting two kinds of test tubes simultaneously, its key is how to guarantee that puncture needle can puncture to enter the zone of can puncturing, and could guarantee normal sampling.
There are two kinds of methods to guarantee that the cellanalyzer puncture needle can puncture at present and enter the punctured zone of common test tube and injecting type test tube:
1) bearing accuracy and the kinematic accuracy of the automatic sampling of raising and mixing mechanism;
2) be that two kinds of test tubes design different swabs respectively to satisfy normal puncture function.
Method 1) shortcoming is: the cost height, and after having used a period of time, need again mechanism to be demarcated and adjusts, the maintenance cost height.Method 2) shortcoming is: troublesome poeration, and need the user to do it yourself to change swab according to different test tube types, in addition, a cellanalyzer is joined two cover swabs, has also increased certain cost.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, provide a kind of and can reduce cost and cleaning swab simple to operate and the application on blood cell analyzer thereof.
For achieving the above object, the present invention has adopted following technical scheme: a kind of cleaning swab, comprise main body, described main body has first surface and second surface, offer internal point from described first surface to second surface, described internal point is crossed by peripheral wall surfaces and bottom surface, run through described bottom surface and second surface and form puncture channel, described puncture channel has puncturing hole and the cleaning chambers that is connected, described main body also has the feed liquor interface and goes out liquid interface, described feed liquor interface and go out liquid interface and all be communicated with described cleaning chambers, described puncturing hole has first axle, described peripheral wall surfaces comprises the guide surface that is connected with described bottom surface, described guide surface and bottom surface form first line segment and second line segment with Plane intersects by described first axle respectively, described first line segment has the slope of relative second line segment, makes the injecting type test tube with second axis slide to described bottom surface under described guide surface.First axle and second axis can overlap, and first axle also can have side-play amount with second axis, as axis shift side-play amount, axis angle side-play amount.
Further, Wherein, u is the friction factor of described guide surface, d 1Be the length of described second line segment, d 2Be the diameter of the head of described injecting type test tube, h is the height of described internal point on described first axle, and Δ is described first axle and the axis shift side-play amount of second axis on the direction of vertical first axle, θ 3Be the angle of described first axle and second axis, θ 2Angle for described first line segment and second line segment.When guide surface had single slope, first line segment can be straight-line segment.When guide surface has a plurality of slopes or slope when changing continuously, first line segment all satisfy above-mentioned formula requirement with the relation of second line segment everywhere.
Further, described peripheral wall surfaces is about described axis symmetry.For example, the cross section of the axis of the vertical puncturing hole of this peripheral wall surfaces can be positive even numbers polygon, rectangle, rhombus, circle or have the shape of incircle.
Further, described guide surface is the surface of revolution.
Further, described guide surface is the conical surface.
Further, described guide surface is slope continually varying curved surface.
Further, described peripheral wall surfaces is the conical surface, as single conical surface or many conical surfaces; Described peripheral wall surfaces also can be slope continually varying curved surface; Namely this peripheral wall surfaces all can be for guiding the guide surface of injecting type test tube.
Further, described main body also has air bleed slot, and described air bleed slot is communicated with described cleaning chambers and atmosphere.
Further, described air bleed slot is opened in described first surface, and described air bleed slot and described internal point directly connect.
Further, described puncturing hole is included in first puncturing hole and second puncturing hole that lays respectively at described cleaning chambers both sides on the described axis direction, and described first puncturing hole and second puncturing hole are all about described axis symmetry.
Further, described cleaning swab also comprises sprue, and described cleaning chambers has opening, and described sprue seals described opening by interference fit.
Further, described cleaning swab also comprises liquid inlet joint and fluid joint, and described liquid inlet joint is arranged at described feed liquor interface, and described fluid joint is arranged at the described liquid interface that goes out.
A kind of described cleaning swab is in blood cell application analytically.
The invention has the beneficial effects as follows: fall into the internal point to main body before the injecting type test tube punctures earlier after the sample mixing is intact, by the sliding force along peripheral wall surfaces make slide to the bottom surface under the injecting type test tube after, the injecting type test tube axis that is produced by the error of auto injection transmission and motion and the deviation distance of puncture needle axis reduce, thereby can guarantee that puncture needle can be punctured to the punctured zone of injecting type test tube, make this cleaning swab can satisfy the puncture demand of common test tube and injecting type test tube simultaneously at the automatic sample handling system of general precision, reduced cost, simple to operate.
Description of drawings
Fig. 1 is the structural representation of common test tube;
Fig. 2 is the structural representation of injecting type test tube;
Fig. 3 is the three-dimensional exploded view that present embodiment is cleaned swab;
Fig. 4 is the stereographic map that present embodiment is cleaned swab;
Fig. 5 is the cut-open view that present embodiment is cleaned swab;
Fig. 6 is that present embodiment is cleaned swab to the synoptic diagram of injecting type test tube centering;
Fig. 7 is that puncture needle cleans the structural representation that the common test tube on the swab punctures to being supported on present embodiment;
Fig. 8 is that puncture needle cleans the structural representation that the injecting type test tube on the swab punctures to being supported on present embodiment;
Force analysis figure when Fig. 9 is the skew of injecting type test tube axis shift;
Force analysis figure when Figure 10 is the angular deflection of injecting type test tube axis;
Figure 11 is the synoptic diagram that the injecting type test tube falls into internal point;
Figure 12 is the synoptic diagram that cleans second embodiment of swab;
Figure 13 is the synoptic diagram that cleans the 3rd embodiment of swab;
Figure 14 is the synoptic diagram that cleans the 4th embodiment of swab.
Embodiment
By reference to the accompanying drawings the present invention is described in further detail below by embodiment.
Extremely shown in Figure 11 as Fig. 3, present embodiment is cleaned swab 25 and is used for supporting test tube in puncture needle 28 puncture sampling processes, and after sampling finished, the cleaning swab can clean the remaining blood sample on the puncture needle, and sampling needle carried out drying, bring pollutant when avoiding the next time sampling into.Clean swab 25 and comprise main body 5, main body 5 has first surface 19 and second surface 20, have internal point 23 from first surface 19 to second surface 20, this internal point 23 is crossed by peripheral wall surfaces 12 and bottom surface 22, run through this bottom surface 22 and second surface 20 formation puncture channel 24, puncture channel 24 comprises with the puncturing hole 29 of puncture needle 28 couplings and for the cleaning chambers 15 that cleans puncture needle 28, puncture needle 28 has first axle L1, the axis of puncturing hole 29 also is this first axle L1, and the internal diameter of cleaning chambers 15 is greater than the diameter of puncture needle 28.Main body 5 also has feed liquor interface 18 and goes out liquid interface 10, this feed liquor interface 18 and go out liquid interface 10 and all be communicated with cleaning chambers 15.In addition, can also be provided for the fixing screw hole 13 of fixation on this main body 5.
On the first axle direction of puncturing hole 29, the aperture of internal point 23 from top to bottom reduces gradually.The peripheral wall surfaces 12 of internal point can be circular conical surface, this conical surface and puncturing hole 29 coaxial cables, and the bottom surface 22 of internal point 23 is the plane.
Puncturing hole 29 can be included in first puncturing hole 11 and second puncturing hole 16 that lays respectively at cleaning chambers 15 upper and lower both sides on the first axle direction of puncturing hole 29, internal point 23, first puncturing hole 11, cleaning chambers 15 and second puncturing hole 16 connect in turn, and first puncturing hole 11, second puncturing hole 16, internal point 23 and puncture needle 28 can coaxial cables.First puncturing hole 11 and second puncturing hole 16 are used for biopsy needle guide 28 and penetrate test tube, the aperture of this first, second puncturing hole and the diameter of puncture needle coupling.
Clean swab 25 and can also comprise liquid inlet joint 3 and fluid joint 1, this liquid inlet joint 3 is fixedly installed on feed liquor interface 18 and can seals by feed liquor O-ring seal 4, and this fluid joint 1 is fixedly installed on out liquid interface 10 and can seals by fluid O-ring seal 2.
As shown in Figure 7, take a sample by automatic sampler structure and mixing mechanism and mixing after, under cylinder promoted, the head of common test tube 26 withstood on the first surface 19 that cleans the swab main body, puncture needle 28 starts puncture then, penetrates and in vitro inhales sample.The location of automatic sampler structure and mixing mechanism and movement warp can cause the axis L2 of puncture needle axis L1 and common test tube to occur necessarily departing from, because the diameter phi D1 in the punctured zone of common test tube is bigger, so the sampling mechanism of general precision and mixing mechanism can meet the demands.
As shown in Figure 8, injecting type test tube 27 is after finishing sampling and mixing, under cylinder promotes, its head at first drops on the peripheral wall surfaces 12 of internal point, make the injecting type test tube slide to the bottom surface 22 of internal point for 27 times by the sliding force along peripheral wall surfaces 12, puncture needle 28 starts puncture then, penetrates and in vitro inhales sample.
The location of automatic sampler structure and mixing mechanism and movement warp cause the first axle L1 of puncture needle and injecting type test tube the second axis L3 depart from the two kinds of situations that comprise: axis shift is offset (as shown in Figure 9, the shifted by delta vertical with first axle takes place with the second axis L3 of injecting type test tube in the first axle L1 of puncture needle) and axis angular deflection (the second axis L3 of the first axle L1 of puncture needle and injecting type test tube generation angular deflection θ as shown in figure 10, 3).
If the second axis L3 of injecting type test tube 27 and the first axle L1 of puncture needle are subjected to displacement skew, the test tube head drops on earlier on the peripheral wall surfaces 12 of internal point, the test tube force analysis as shown in figure 10, N, F 2Be the suffered component of cylinder clamping power F on both direction of test tube, vertical this peripheral wall surfaces 12 of component N wherein, F 2Parallel this peripheral wall surfaces, f is the friction force of peripheral wall surfaces, f=Nu=Fcos θ 2U (u is the friction factor between test tube and the peripheral wall surfaces).In order to reach the centering effect, namely allow test tube slide into the bottom surface 22 of internal point, sliding force F voluntarily down 2Need satisfy f<F 2=Fsin θ 2, can draw θ 2>arctanu, θ 2Angle for bottom surface 22 and peripheral wall surfaces 12.
The first axle generation angular deflection θ of the second axis L3 of injecting type test tube 27 and puncture needle 3After, the test tube claw has individual reacting force N to test tube 2, the test tube force analysis decomposes toward peripheral wall surfaces 12 directions and vertical direction thereof institute is strong as shown in figure 10, guarantee that test tube can slide to bottom surface 22 for 12 times along peripheral wall surfaces and need to satisfy sliding force along peripheral wall surfaces 12 greater than friction force, that is:
F sin(θ 23)+N 2cos(θ 23)>F cos(θ 23)u-N 2sin(θ 23)u (1)
U is the friction factor between test tube and the internal point peripheral wall surfaces in the formula.
Make x=θ 23, then inequality (1) can turn to:
Again because As long as therefore satisfy tgx>u, i.e. θ 2>θ 3+ arctanu, test tube journal offset puncture needle axis ± θ 3The injecting type test tube can both slide to the bottom surface 22 of internal point down after the angle.
The head that also must guarantee injecting type test tube under cylinder promotes simultaneously can fall into to internal point earlier.As shown in figure 12, cause test tube axis and sampling needle axis runout Δ by automatic sampling and mixing mechanism location and movement warp after, the test tube head will fall in the internal point, needs satisfied
Figure BDA0000042449310000053
Can get:
&theta; 2 < arcctg ( &Delta; h + d 2 2 h - d 1 2 h ) .
Comprehensively above-mentioned, guarantee that the injecting type test tube can slide to the bottom surface of internal point down, guaranteed by the cone angle design of peripheral wall surfaces, namely U is the friction factor of peripheral wall surfaces in the inequality, d 1Be the length of bottom surface, it can be by the diameter d of the head of injecting type test tube 2And the diameter in the punctured zone of injecting type test tube determines that taper peripheral wall surfaces height h determines test tube axis and sampling needle axis runout distance, delta and angular deflection amount θ by lancet puncture stroke and supported smallest sample amount 3Location and movement warp by auto injection sampling and mixing mechanism determine that the cone angle of this peripheral wall surfaces has namely reflected the inclined degree of peripheral wall surfaces 12 with respect to bottom surface 22.
Therefore at the automatic sample handling system of general precision, can realize the puncture sampling of compatible common test tube of while and injecting type test tube by the internal point that has the conical surface in the increase of swab bodies top.
Test tube is finished the suction sample by vacuum in managing, and in vitro still has negative pressure after inhaling sample, and after lancet puncture was advanced test tube, at first should discharging in vitro remaining negative pressure, to guarantee to inhale sample stable.As shown in Figure 4, the first surface of main body has air bleed slot 14, this air bleed slot 14 connects with internal point 23, withstand on the first surface 19 of main body at the test tube head after, one end of air bleed slot 14 communicates with atmosphere, and the other end communicates with feed liquor interface 18 by internal point 23, first puncturing hole 11, cleaning chambers 15.In addition, feed liquor interface 18 communicates with the air bleed slot of puncture needle by pipeline again, and puncture needle in vitro communicates with atmosphere after inserting test tube, thereby realizes the venting function.Because air bleed slot 14 is located at internal point 23 places, directly do not link to each other with cleaning chambers 15, but be communicated with cleaning chambers 15 again by internal point 23, first puncturing hole 11, thus the risk that can reduce air bleed slot 14 leakages, spatter liquid.Certainly, air bleed slot 14 also can be opened other positions in main body, as open at first surface but not and internal point directly connect or open main body on the side 37 between first surface and the second surface.
Puncture needle sampling is finished the back withdraw of the needle to original position, 18 feedings of feed liquor interface, and puncture needle 28 is finished the cleaning of puncture needle in cleaning chambers 15, and waste liquid is by going out liquid interface 10 discharges.Feed liquor interface 18 is given gas, and puncture needle 28 outer walls are dried up, and raffinate is discharged by going out liquid interface 10.Can be arranged in just down going out liquid interface 10, waste liquid discharge opeing under the gravity effect is more thorough.
In addition, clean swab and can also comprise sprue 6, cleaning chambers 15 can have opening, and sprue 6 is by this opening 30 of interference fit seal.The puncture channel 24 of cleaning the swab body can also comprise the aperture greater than the seat hole 17 of second puncturing hole, and bottom O-ring seal 7 is pressed in this hole 17 by backing plate 8, and this backing plate 8 is fixed on the second surface 20 of main body by screw 9.
As shown in figure 12, it is for cleaning second embodiment of swab.The key distinction of this embodiment and first embodiment is: the peripheral wall surfaces 12 of internal point is the many conical surfaces with at least two taperings.These many conical surfaces can comprise first conical surface 31 that is positioned at the top and second conical surface 32 that is positioned at the below, the bottom surface 22 of internal point is positioned at the bottom of second conical surface 32, first conical surface 31, second conical surface 32 and puncture needle coaxial cable, and this first conical surface 31 has different taperings with second conical surface 32.Test tube can slide to the bottom surface 22 of internal point along first conical surface 31, second conical surface for 32 times.These many conical surfaces can be the surfaces of revolution with the puncturing hole coaxial cable.
As shown in figure 13, it is for cleaning the 3rd embodiment of swab.The key distinction of this embodiment and first embodiment is: the peripheral wall surfaces 12 of internal point is arc surface, and the slope of this arc surface changes continuously.This arc surface is the surface of revolution with the puncturing hole coaxial cable.
As shown in figure 14, it is for cleaning the another kind of embodiment of swab, the key distinction of this embodiment and first embodiment is: body 5 can comprise separate two parts, be respectively first main body 33 and second main body 34, the upper surface of this first main body 34 is first surface 19, and the lower surface of this second main body 34 is second surface 20.During assembling, first main body 33 is fixed on the upper surface of second main body 34 by screw.Internal point 23 is crossed by the peripheral wall surfaces 12 of being located at first main body 33 and the upper surface 35 of being located at second main body 34, and puncture channel 24 runs through upper surface 35 and the lower surface of second main body.
For cleaning swab, it has main body, main body has first surface and second surface, have internal point from first surface to second surface, internal point has peripheral wall surfaces and bottom surface, runs through this bottom surface and second surface and is formed with puncture channel, puncture channel comprises puncturing hole and the cleaning chambers that is connected, puncturing hole is used for biopsy needle guide and punctures, puncturing hole and puncture needle coaxial cable, and the aperture of puncturing hole and puncture needle coupling.The peripheral wall surfaces of internal point is around the first axle of this puncturing hole, the part that slides to the bottom surface under the test tube that can guide of this peripheral wall surfaces is defined as guide surface, the bottom surface is the plane, the plane of the first axle by puncturing hole is defined as first reference planes, guide surface and first reference planes intersect and form first line segment, bottom surface and first reference planes intersect formation second line segment, and relative second line segment of this first line segment has slope, and first line segment this first axle relatively also has slope.
For cleaning swab, can be the effect that whole peripheral wall surfaces can both play the guiding test tube, namely can be considered as be guide surface to whole peripheral wall surfaces; Also can be that only the part peripheral wall surfaces can play guiding function, namely this peripheral wall surfaces be by the guide surface that can play guiding function and the surface composition that can not play guiding function.The quantity of guide surface can be one or more.For guide surface, it can be the single conical surface with single tapering, the many conical surfaces with many taperings, the inclined-plane with single slope, the inclined-plane with a plurality of slopes or slope continually varying curved surface, and guide surface also can be other surface that can play the effect of guiding test tube.Peripheral wall surfaces can be about the axis symmetry of puncturing hole, can be the surface of revolution centered by this axis as peripheral wall surfaces.
Cleaning swab can be applied on the blood cell analyzer.
Above content be in conjunction with concrete embodiment to further describing that the present invention does, can not assert that concrete enforcement of the present invention is confined to these explanations.For the general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.

Claims (11)

1. one kind is cleaned swab, it is characterized in that: comprise main body, described main body has first surface and second surface, offer internal point from described first surface to second surface, described internal point is crossed by peripheral wall surfaces and bottom surface, run through described bottom surface and second surface and form puncture channel, described puncture channel has puncturing hole and the cleaning chambers that is connected, described main body also has the feed liquor interface and goes out liquid interface, described feed liquor interface and go out liquid interface and all be communicated with described cleaning chambers, described puncturing hole has first axle, described peripheral wall surfaces comprises the guide surface that is connected with described bottom surface, described guide surface and bottom surface form first line segment and second line segment with Plane intersects by described first axle respectively, described first line segment has the slope of relative second line segment, makes the injecting type test tube with second axis slide to described bottom surface under described guide surface.
2. cleaning swab as claimed in claim 1, it is characterized in that: described guide surface is about described first axle symmetry.
3. cleaning swab as claimed in claim 2, it is characterized in that: described guide surface is the surface of revolution.
4. cleaning swab as claimed in claim 3, it is characterized in that: described guide surface is the conical surface.
5. cleaning swab as claimed in claim 3, it is characterized in that: described guide surface is slope continually varying curved surface.
6. as any described cleaning swab among the claim 1-5, it is characterized in that: described main body also has air bleed slot, and described air bleed slot is communicated with described cleaning chambers and atmosphere.
7. cleaning swab as claimed in claim 6, it is characterized in that: described air bleed slot is opened in described first surface, and described air bleed slot and described internal point directly connect.
8. cleaning swab as claimed in claim 6, it is characterized in that: described puncturing hole is included in first puncturing hole and second puncturing hole that lays respectively at described cleaning chambers both sides on the described axis direction, and described first puncturing hole and second puncturing hole are all about described first axle symmetry.
9. cleaning swab as claimed in claim 8, it is characterized in that: also comprise sprue, described cleaning chambers has opening, and described sprue seals described opening by interference fit.
10. as any described cleaning swab among the claim 1-5, it is characterized in that: &theta; 3 + arctan u < &theta; 2 < arcctg ( &Delta; h + d 2 2 h - d 1 2 h ) , Wherein, u is the friction factor of described guide surface, d 1Be the length of described second line segment, d 2Be the diameter of the head of described injecting type test tube, h is the height of described internal point on described first axle, and Δ is described first axle and the axis shift side-play amount of second axis on the direction of vertical first axle, θ 3Be the angle of described first axle and second axis, θ 2Angle for described first line segment and second line segment.
11. the application of any described cleaning swab on blood cell analyzer among the claim 1-5.
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CN108931415B (en) * 2017-05-23 2021-02-19 北京诚智光辉科技有限公司 Cell film-making dyeing all-in-one with wiper mechanism
CN114460320B (en) * 2022-04-14 2022-06-21 深圳市帝迈生物技术有限公司 Sample analyzer and sample detection process thereof
CN117302743A (en) * 2023-09-28 2023-12-29 中元汇吉生物技术股份有限公司 Reagent bottle, reagent kit, cleaning system and cleaning method

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