CN102349861B - Phenolic acid modified collagen mask and preparation method thereof - Google Patents
Phenolic acid modified collagen mask and preparation method thereof Download PDFInfo
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- CN102349861B CN102349861B CN 201110309522 CN201110309522A CN102349861B CN 102349861 B CN102349861 B CN 102349861B CN 201110309522 CN201110309522 CN 201110309522 CN 201110309522 A CN201110309522 A CN 201110309522A CN 102349861 B CN102349861 B CN 102349861B
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- acid
- collagen
- phenolic
- phenolic acid
- facial mask
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- 230000009967 tasteless effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
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- Cosmetics (AREA)
Abstract
本发明提供了一种酚酸类改性胶原蛋白面膜及其制备方法。本方法首先将质量分数为(1～30)%的胶原蛋白水溶液和质量分数为(0.1～3)%的酚酸类物质水溶液于pH5~10温度20~60℃共混搅拌20~60分钟，然后添加质量分数为(1～20)%的辅助添加剂水溶液，并于温度20~60℃继续搅拌20~40分钟，之后将混合溶液倒入模具中成型，于温度20~50℃干燥6~24小时，得胶原蛋白面膜。本发明制备的胶原蛋白面膜产品安全有效，无毒副作用；具有良好的热稳定性、韧性、延展性和粘连性，可与肌肤良好贴合；在酚酸类物质的辅助下可以达到抗皱、美白、保湿、清洁滋润肌肤等功效；面膜废弃物可降解，不会造成环境污染。The invention provides a phenolic acid modified collagen facial mask and a preparation method thereof. In this method, the collagen aqueous solution with a mass fraction of (1-30)% and the phenolic acid aqueous solution with a mass fraction of (0.1-3)% are blended and stirred for 20-60 minutes at a pH of 5-10 and a temperature of 20-60°C. Then add an auxiliary additive aqueous solution with a mass fraction of (1-20)%, and continue to stir at a temperature of 20-60°C for 20-40 minutes, then pour the mixed solution into a mold for molding, and dry at a temperature of 20-50°C for 6-24 Hours, get a collagen mask. The collagen mask product prepared by the present invention is safe and effective, has no toxic and side effects; has good thermal stability, toughness, ductility and adhesion, and can fit well with the skin; with the assistance of phenolic acids, it can achieve anti-wrinkle and whitening , Moisturizing, cleansing and nourishing the skin and other effects; the mask waste can be degraded and will not cause environmental pollution.
Description
Technical field
The present invention relates to cosmetics and technology of preparing thereof, in particular to a kind of phenolic acid modified collagen mask and preparation method thereof, belong to the daily cosmetics field.
Background technology
The human facial film that uses is with a long history as cosmetic tool, can trace back to ancient Egypt and Chinese Tang Dynasty.Facial film is to apply in face by the dressing with one deck heterogeneity, reaches the purpose of beauty treatment to intercept skin and contacting of air.When this one deck dressing tightly is attached on the skin, can suppress the secretion of sebum and the evaporation of sweat, so that the skin temperature rises; After the skin temperature rises, again can blood circulation promoting, so that darker wider in the iuntercellular diffusion of the nutrient that infiltrates skin.Simultaneously the skin surface moisture that can't evaporate then can reside in epidermal area, because the moisture of epidermal area is full, so that skin also can seem is smooth tight, it is light that microgroove also can become; In addition, the rising of skin temperature can make cutin softening, the pore expansion; Pore expansion again can be so that being deposited in the sweat mixed with dirt of the inside takes advantage of the occasion to get rid of, so facial film can clean skin comparatively thoroughly.
Collagen protein is that occurring in nature exists the most widely animal proteinum, and it has good repair to ultraviolet damage, and it has good compatibility, stability and antibiotic property in cosmetic formulations.In addition, collagen protein and skin have fabulous adsorptivity and the compatibility, the function that has the blocking-up brown pigment to generate.Simultaneously, contain the hydrophilic groups such as amino, hydroxyl in the collagen hydrolysate polypeptide chain, human body skin is had moisture-keeping function.In addition, collagen protein uses in conjunction with the skin care item late frost and has skin-active reparation and moisturizing lock water, accelerate cellular replication propagation, significantly improves cuticular accretion rate, repairs damaged cell, reduces wrinkle and increase elasticity and efficiently lock the water effect.Experiment shows that hydrolytic collagen solution also has antibacterial antiseptic effect after deliberation.But, collagen protein itself has the shortcoming of mechanical performance and poor heat stability, has limited its application.Normally used collagen-base biomaterial all will pass through modification, to improve the performance of collagen protein materialization aspect.
What collagen-modified method application was more is chemical crosslinking, modifier is mainly glutaraldehyde, but the course of reaction of glutaraldehyde and albumen is reversible, generate the structural instability of schiff alkali, be easy to be hydrolyzed the free micromolecule aldehyde (CN1861801A) that generation has metabolism toxicity, can not satisfy the bio-safety requirement of facial film.The modifier phenolic acid that the present invention uses, it has nontoxic, biodegradable, a large amount of advantages that exist of nature, and the phenolic hydroxyl group that exists in a large number in the molecular structure can form hydrogen bond with collagen protein, and its hydrophobic part is because the hydrophobic group combination in the collagen protein, high with the reactivity of collagen protein, be a kind of desirable collagen-modified dose.
Simultaneously, phenolic acid not only can promote skin epithelial cells mitosis and growth, reduces apoptotic generation, accelerates to a certain extent the cell turnover replacement and promotes growth; And can shielding of ultraviolet, the activation of check melanin cell alleviates the precipitation of pigment, effectively suppresses spot and pigment, thereby skin is played the effect of whitening; Can also reduce the generation of Skin Cell lipid peroxidation, increase the GSH-Px level of lipoid peroxidization resistant, prevent the damage of radical pair cell, promote preferably the growth of Skin Cell, have the effect of protection skin, part delay skin aging.In addition, phenolic acid is because the affinity of itself and protein etc. makes it to skin preferably adhesive ability be arranged under the waterproof condition, from but thick pore shrinks, sweat gland expands, make lax skin contraction, tighten and reduce wrinkle, the skin smooth exquisiteness that seems; Secondly, phenolic acid can reduce the excessive secretion of greasy skin sebum, keeps skin clean.Can increase the stability of phenolic acid with the complex of collagen protein, improve the moisture-keeping nutrient ability of skin, especially effective to coarse skin.
Up to the present, not yet there are pertinent literature or patent of invention that report was carried out in this research.
Summary of the invention
Simple collagen protein face heat stability is low, toughness, ductility and adhesive are poor, can not satisfy preferably the serviceability of facial film, traditional method of modifying may be hydrolyzed and produce the free micromolecule aldehyde that metabolism toxicity is arranged, and the interpolation of phenolic acid not only can the Effective Raise collagen protein face mechanical performance, the effect of whitening, crease-resistant, moisturizing, cleaning Glycerin can also be provided preferably, the invention provides a kind of phenolic acid modified collagen mask and preparation method thereof for this reason.
The present invention is achieved through the following technical solutions, and except specifying, related umber is parts by weight, and percentage ratio is percetage by weight.
The invention provides a kind of phenolic acid modified collagen mask, its preparation method is specific as follows:
(1) preparing respectively collagen aqueous solution and the mass fraction that mass fraction is (1～30) % is the phenolic acid aqueous solution of (0.1～3) %, then two kinds of solution are mixed and regulate pH to 5 ~ 10, and under 20 ~ 60 ℃ of conditions of temperature stirring reaction 20 ~ 60 minutes, prepare complex liquid;
(2) the preparation mass fraction is the auxiliary additive aqueous solution of (1～20) % and adds in the complex liquid, continues to stir 20 ~ 40 minutes in 20 ~ 60 ℃ of temperature afterwards, prepares mixed solution;
(3) pour above-mentioned mixed solution into die for molding, in 20 ~ 50 ℃ of dryings of temperature 6 ~ 24 hours, take off film and namely obtain collagen protein face.
In above-mentioned technology case, described phenolic acid is any one or a few mixture in caffeic acid, P-coumaric acid, ferulic acid, Hesperetic acid, salvianolic acid A, salvianolic acid B, catechuic acid, vanillic acid, syringic acid, salicylic acid, chlorogenic acid, gallic acid, the meson acid.
In above-mentioned technology case, the ratio of collagen protein and phenolic acid is counted (25～2000) by dry weight: 1.
In order to improve the mechanical performance of facial film provided by the invention, also need to add a certain amount of auxiliary additive.The auxiliary additive that the present invention uses is any one or a few mixture in glycerol, propylene glycol, mannitol, sorbitol, xylitol, maltose alcohol, spermol, monoglyceride, xanthan gum, alginate jelly, carrageenan, Radix Acaciae senegalis, guar gum, tragacanth, the tamarind gum.
In above-mentioned technology case, the ratio of collagen protein and auxiliary additive is counted (1～200) by dry weight: 1.
Collagen protein face provided by the invention can be applicable to the daily cosmetics field.
Compared with the prior art the present invention has many-sided good effect and advantage, but concrete inductive generalization is as follows:
(1) the present invention adopts collagen protein as primary raw material, by adding phenolic acid and auxiliary additive, control membrance casting condition, the modified collagen protein facial mask of directly making, compare and traditional polyvinyl alcohol and the easier degraded of polyvinylpyrrolidone--based facial film, better environmental-protecting performance;
(2) the present invention is prepared from by the natural animal-plant extraction of substance fully, and is nontoxic, tasteless, non-stimulated, have no side effect; The aminoacid of collagen protein forms identical with human body skin, thus good with skin-friendliness, affinity is strong, and good moisturizing and the clean skin function of deep layer is arranged, and can also replenish the collagen protein that loses in the skin;
(3) the phenolic acid reactivity of using among the present invention is high, and the phenolic acid of trace can make toughness, ductility, adhesive and the heat stability of collagen protein obtain larger improvement.The good biology performance such as the avirulence that has except itself, biodegradability, itself also has the effect of whitening, crease-resistant, moisturizing, cleaning Glycerin;
(4) the prepared facial film of technique of the present invention has good toughness and ductility, can extend arbitrarily according to the different facial characteristics of user, and self have good viscosity, when peeling off with the oils and fats on the skin, perspiration and dirt along with facial film is removed together;
(5) be a kind of novel facial film with the prepared facial film of technique of the present invention, higher scientific and technological added value is arranged, have wide potential market, significant to the developmental research of daily cosmetics material, have higher economic benefit and social benefit.
The specific embodiment
The below provides three embodiment of the present invention, by embodiment the present invention is specifically described.Be necessary to be pointed out that at this; embodiment only is used for the present invention is further detailed; can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
In following examples, except specifying, related umber is parts by weight, and percentage ratio is percetage by weight.
Embodiment 1
Take by weighing in the water that 100 parts of collagen protein dry products add 900 parts to, swelling after 50 minutes under the room temperature places under 60 ℃ of left and right sides water bath condition constantly stir about to obtain mass fraction in 40 minutes and is about 10% collagen solution.Take by weighing simultaneously in the water that 10 parts of caffeic acids add 990 parts to, continuous stir about 12 hours about 20 ℃ obtains mass fraction and is about 1% caffeic acid solution.Under 50 ℃, in collagen protein and caffeic acid dry weight than being the ratio blend of 1000:1, use sodium carbonate and acetum adjusting pH to 8, and added the continuous stir about of an amount of water 30 minutes, obtain concentration is about caffeic acid-collagen protein of 5% with collagen protein dry product weighing scale complex liquid.Take by weighing in the water that 10 parts of auxiliary additives (in propylene glycol and xylitol dry weight than being the ratio blend of 1:1) add 990 parts to, continuous stir about 1 hour about 20 ℃ obtains mass fraction and is about 1% auxiliary additive solution.Than in the complex liquid of caffeic acid-collagen protein, adding auxiliary additive for the ratio of 5:1, in 50 ℃ of stir abouts 30 minutes, be configured to the mixed liquor of caffeic acid-collagen protein-auxiliary additive in collagen protein and auxiliary additive dry weight.The mixed liquor of caffeic acid-collagen protein-auxiliary additive is injected mould, and lower the maintenance about 20 hours, take off film and namely obtain collagen protein face in about 20 ℃.
Embodiment 2
Take by weighing in the water that 20 parts of collagen protein dry products add 980 parts to, swelling after 20 minutes under the room temperature places under 40 ℃ of left and right sides water bath condition constantly stir about to obtain mass fraction in 20 minutes and is about 2% collagen solution.Take by weighing simultaneously in the water that 5 parts of phenolic acids (in ferulic acid and Hesperetic acid dry weight than being the ratio blend of 2:1) add 995 parts to, continuous stir about 6 hours about 30 ℃ obtains mass fraction and is about 0.5% phenolic acid aqueous solution.Under 50 ℃, in collagen protein and phenolic acid dry weight than being the ratio blend of 1000:1, use sodium carbonate and acetum adjusting pH to 8.5, and added the continuous stir about of an amount of water 40 minutes, obtain concentration is about phenolic acid-collagen protein of 1% with collagen protein dry product weighing scale complex liquid.Take by weighing in the water that 10 parts of xanthan gum add 990 parts to, continuous stir about 4 hours about 40 ℃ obtains mass fraction and is about 1% auxiliary additive solution.Add in the complex liquid of phenolic acid-collagen protein than the ratio for 20:1 in collagen protein and xanthan gum dry weight, in 60 ℃ of stir abouts 30 minutes, be configured to the mixed liquor of phenolic acid-collagen protein-xanthan gum.The mixed liquor of phenolic acid-collagen protein-xanthan gum is injected mould, and lower the maintenance about 24 hours, take off film and namely obtain collagen protein face in about 25 ℃.
Embodiment 3
Take by weighing in the water that 60 parts of collagen protein dry products add 940 parts to, swelling after 30 minutes under the room temperature places under 30 ℃ of left and right sides water bath condition constantly stir about to obtain mass fraction in 40 minutes and is about 6% collagen solution.Take by weighing simultaneously in the water that 4 parts of phenolic acids (2 parts of catechuic acids, 1 part of salicylic acid, 1 part of gallic acid) add 996 parts to, continuous stir about 9 hours about 30 ℃ obtains mass fraction and is about 0.4% phenolic acid aqueous solution.Under 50 ℃, in collagen protein and phenolic acid dry weight than being the ratio blend of 1500:1, use sodium carbonate and acetum adjusting pH to 7, and added the continuous stir about of an amount of water 40 minutes, obtain concentration is about phenolic acid-collagen protein of 3% with collagen protein dry product weighing scale complex liquid.Take by weighing in the water that 10 parts of auxiliary additives (6 parts of glycerol, 1 part of mannitol, 3 parts of alginate jellys) add 990 parts to, continuous stir about 7 hours about 40 ℃ obtains mass fraction and is about 1% auxiliary additive solution.Add in the complex liquid of phenolic acid-collagen protein than the ratio for 50:1 in collagen protein and auxiliary additive dry weight, in 30 ℃ of stir abouts 30 minutes, be configured to the mixed liquor of phenolic acid-collagen protein-auxiliary additive.The mixed liquor of phenolic acid-collagen protein-auxiliary additive is injected mould, put into baking oven, the lower maintenance about 15 hours, take off film and namely obtain collagen protein face in about 30 ℃.
Claims (6)
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