CN102600019A - Medical hydrogel dressing and preparation method thereof - Google Patents
Medical hydrogel dressing and preparation method thereof Download PDFInfo
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- CN102600019A CN102600019A CN2012100612102A CN201210061210A CN102600019A CN 102600019 A CN102600019 A CN 102600019A CN 2012100612102 A CN2012100612102 A CN 2012100612102A CN 201210061210 A CN201210061210 A CN 201210061210A CN 102600019 A CN102600019 A CN 102600019A
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 61
- 238000002360 preparation method Methods 0.000 title abstract description 14
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 53
- 239000002390 adhesive tape Substances 0.000 claims abstract description 29
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 18
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 15
- 230000001954 sterilising effect Effects 0.000 claims abstract description 10
- 239000004964 aerogel Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 238000010894 electron beam technology Methods 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 28
- 208000027418 Wounds and injury Diseases 0.000 abstract description 28
- 230000029663 wound healing Effects 0.000 abstract description 9
- 239000002994 raw material Substances 0.000 abstract description 7
- 230000001154 acute effect Effects 0.000 abstract description 2
- 230000001684 chronic effect Effects 0.000 abstract description 2
- 238000004132 cross linking Methods 0.000 abstract description 2
- 230000000474 nursing effect Effects 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000005213 imbibition Methods 0.000 description 17
- 230000006870 function Effects 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 210000000416 exudates and transudate Anatomy 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 230000037314 wound repair Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011430 maximum method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
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Abstract
The invention relates to a wound healing hydrogel dressing applicable to nursing various acute and chronic wounds and a preparation method. The hydrogel dressing comprises a hydrogel layer, a fixing non-woven fabric and a medical adhesive tape, the hydrogel layer is fixed on a surface of the non-woven fabric, and the other surface of the non-woven fabric is adhered on the medical adhesive tape. The preparation method includes fixing cross-linking agent on the non-woven fabric; coating solution of a raw material of hydrogel onto one surface of the non-woven fabric, adhering the other surface of the non-woven fabric onto the medial adhesive tape with pressure-sensitive adhesive after crosslinking is finished, arranging the pressure-sensitive adhesive onto one surface of the medical adhesive tape while arranging a separate film backing on the other surface of the medical adhesive tape, and attaching an isolating film on one surface of the hydrogel; and sterilizing after the medical hydrogel dressing is packaged. The medical hydrogel dressing is convenient in use, can rapidly absorb exudation of the wound, prevents the exudation of the wound from excessively steeping the wound, creates a moist wound healing condition, and promotes wound healing. A self-adhesion function of the wound healing hydrogel dressing is greatly convenient for clinic service.
Description
Technical field
The present invention relates to a kind of various acute Wound repair hydrogel dressing of nursing that are applicable to chronic wound; This dressing has unique imbibition and self-adhesion function; Easy to use and can absorb wound exudate, prevent that wound exudate from too much flooding wound surface, and can create little wet wound healing condition; Promote wound healing, the self-adhesion function that it has greatly facilitates clinical use.
Background technology
Repair in trauma is the major issue of face of mankind always, and in order to accelerate wound repair, people hope can find out someway always or medicine promotes or quicken this process.In early days, people are to wound surface, and particularly large-area burn wound adopts dry therapy, mainly are to consider that from the angle of protecting from infection if people find that again wound surface keeps certain moist environment afterwards, wound surface will be healed preferably.Under " wet wound healing " guide of theory, and along with the industrial progress of learning of materialogy, revolutionary variation has taken place in wound dressing; From normal gauze dressing; Through synthetic dressing and biological dressing, arrive the dressing of new medical biosynthesis again, these new pattern compress are applicable to different wounds and different healing periods with plurality of raw materials, multiple dosage form; Wherein, the dressing of hydrogel class is exactly wherein representative a kind of.
The dressing of hydrogel class has unique tridimensional network, can effectively moisture be locked in wherein, when making this type dressing cover on the wound surface, can slowly discharge moisture, keeps little wet environment of wound surface, promotes wound healing.Yet, blemish in an otherwise perfect thing be to adopt the hydrogel of prepared in various methods at present; Though also have certain imbibition ability; But this imbibition ability normally needs 24h even longer time to realize, so slow rate of liquid aspiration can not satisfy clinical needs; Therefore the dressing of hydrogel class can only be used to not have the repairing phase of wound surface sepage mostly, this big limitations the dressing of hydrogel class in the clinical scope of application.In addition,, make it be difficult to combine, during clinical use, need in addition employing medical adhesive tape or other medical apparatus and instruments to fix, make the use of hydrogel class dressing become loaded down with trivial details with other band medical adhesive tape because hydrogel has certain water content.
Receive the restriction of hydrogel class dressing processing technology, the batch process of hydrogel class dressing is restricted, this has directly caused this type dressing in clinical use cost, has increased patient's burden.
Patent CN1273128A discloses a kind of compound hydrogel wound dressing and synthetic method thereof, is made up of the polymeric film of synthetic high-hydroscopicity hydrogel of crosslinking with radiation and air-moisture-permeable.Its radiation synthesis process is that material and the water that hydrogel is used mixes, and solution casting solidifies the electron beam or the gamma-radiation irradiation that afterwards are selected from 15-100KGY with radiation dose in mould, and the one side of hydrogel covers ventilated membrane.The synthetic method of the compound hydrogel wound dressing of mentioning in the patent; Be to make the dressing of hydrogel class at present to use maximum methods; The aerogel dressing of this method preparation has good biological safety; Take other suitable manner to sterilize after but the hydrogel of this method preparation need cover ventilated membrane, this has increased production cost virtually again.And though the hydrogel that adopts the method introduced in the patent to prepare has very high water absorption, the speed that absorbs water is slow, and the water absorbing properties in its 30 minutes is limited, the quick imbibition problem in the time of can not solving clinical use.
Summary of the invention
Technical problem to be solved by this invention provides a kind of aerogel dressing with imbibition and self-adhesion function, makes this needed raw material of aerogel dressing and extracts from marine organism material, has very high biological safety; Preparation technology is simple and easy to the degree of dependence of equipment low; Be easy to produce in batches, do not add any poisonous and harmful substance in the manufacturing process, the aerogel dressing that obtains ability fast Absorption wound exudate; Has good comfort, anti-water resistance bacterium property and autohension.On the other hand, the invention provides a kind of method for preparing, and this method for preparing is convenient to large-scale production with imbibition and self-adhesion function water gel dressing.
The technical scheme that the present invention solves the problems of the technologies described above is following: a kind of aerogel dressing with imbibition and self-adhesion function has 5 layers of structure, is followed successively by from top to bottom: separating film layer, hydrogel layer, nonwoven layer, medical adhesive tape layer (medical adhesive tape of band pressure sensitive adhesive), stripping film backing layer.Separating film layer and stripping film backing layer can be release paper or mould release membrance.
The method for preparing of aerogel dressing with imbibition and self-adhesion function is following: cross-linking agent is fixed on the non-woven fabrics; The hydrogel material solution is applied on the wherein one side of non-woven fabrics; After treating crosslinked completion, the another side of non-woven fabrics is attached on the medical adhesive tape of band pressure sensitive adhesive, medical adhesive tape one is worn pressure sensitive adhesive one and is worn the stripping film backing; For preventing that hydrogel from polluting, and simultaneously encloses isolating membrane at hydrogel.
Cross-linking agent is fixed on the non-woven fabrics, and the cross-linking agent of use comprises inorganic Ca
2+, Zn
2+, Ag+, nano-silver ionic, Fe
2+Or Fe
3+, the above-mentioned ion of every square metre of fixing 0.001～0.1 mol of non-woven fabrics, preferred Ag+ or nano-silver ionic.The non-woven fabrics that uses also can be undressed calcium alginate non-woven fabrics, or other contains above-mentioned ionic non-woven fabrics, and the non-woven fabrics specification is 60g/m
2～200 g/m
2
The hydrogel raw material uses natural hydrophilic high molecular material; Comprise sodium alginate, carboxymethyl cellulose, carboxymethyl chitosan and hyaluronate sodium; Also can use the mixture of above-mentioned raw materials, the concentration of used hydrogel material solution is 0.5%～10% (percentage by weight).
Thickness with hydrogel layer of imbibition and self-adhesion function is 0.1mm～3mm.
Content with water in the aerogel dressing of imbibition and self-adhesion function is 55%～95% (percentage by weight).
The optional gamma-radiation of sterilization method, electron beam or high pressure steam sterilization with aerogel dressing of imbibition and self-adhesion function.
Building-up process with aerogel dressing of imbibition and self-adhesion function: the hydrogel raw material is made into certain density solution, is coated on the good non-woven fabrics of pretreatment, after 5-10 minute; Hydrogel solidifies, and is crosslinked on non-woven fabrics, will transfer on the medical adhesive tape of band pressure sensitive adhesive and stripping film backing layer with the non-woven fabrics of hydrogel layer; For preventing that hydrogel from polluting; Cover release paper or mould release membrance on the hydrogel layer, be sealed in the aerogel dressing of making in the packaging bag after, sterilization.
The invention has the beneficial effects as follows: at the aerogel dressing with imbibition and self-adhesion function that adopts the aforesaid way preparation, hydrogel layer only combines with the upper epidermis of non-woven fabrics, can not infiltrate into the lower floor of non-woven fabrics; Therefore the lower floor of non-woven fabrics still can keep dry weight; After this made and is applied to the aerogel dressing card on the wound surface, wound exudate can be absorbed by non-woven fabrics moment, and absorptive capacity is with the thickness scalable of non-woven fabrics; When the needs absorptive capacity is big; Can use the non-woven fabrics of big grammes per square metre to make aerogel dressing, otherwise, as the same.
Adopt the aerogel dressing with imbibition and self-adhesion function of aforesaid way preparation can active adjustment wound surface humidity, when wound surface has sepage, can absorb rapidly, when wound surface is dry, can moisture be provided, keep the little wet environment of wound surface, the promotion wound healing to wound surface.
Adopt the aerogel dressing with imbibition and self-adhesion function of aforesaid way preparation; Employed is the medical adhesive tape of band pressure sensitive adhesive, therefore, possesses the self-adhesion function; And hydrogel layer is media with the non-woven fabrics; Can stick to well on the medical adhesive tape, through with the synergism of medical adhesive tape, make aerogel dressing have good comfort.
Adopt its hydrogel layer of aerogel dressing with imbibition and self-adhesion function of aforesaid way preparation directly to contact with wound surface, the hydrogel raw material all adopts the natural biological macromolecular material, and its safety is confirmed.And this hydrogel does not add any cross-linking agent or other adjuvant with safety hazards in the preparation process.
Adopt the aerogel dressing preparation technology with imbibition and self-adhesion function of aforesaid way preparation easy, do not need equipment special, costliness to accomplish scale production.
Description of drawings
Fig. 1 is the structural representation of this medical aquogel dressing.
In the accompanying drawing, the list of parts of each label representative is following:
1, hydrogel, 2, non-woven fabrics, 3, band pressure sensitive adhesive medical adhesive tape, 4, release paper or film.
The specific embodiment
Below in conjunction with accompanying drawing principle of the present invention and characteristic are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
As shown in Figure 1, [embodiment 1] is 60 g/m with specification
2 Non-woven fabrics 2 use finite concentration CaCl
2Or ZnCl
2Solution-treated is about to non-woven fabrics 2 and is immersed in the cross-linking agent solution, and fixedly cross-linking agent makes the Ca of having 0.01mol on every square metre of non-woven fabrics
2+Or Zn
2+, dry for standby.Sodium alginate is made into 3% aqueous solution, is coated on the non-woven fabrics of handling well 2, left standstill 5-10 minute, hydrogel 1 crosslinked completion is combined into an integral body with 2 layers of non-woven fabrics.To the medical adhesive tape 3 of band pressure sensitive adhesive, described medical adhesive tape 3 can be the PU film medical adhesive tape of waterproof and breathable with this global transfer.2 layers of the non-woven fabrics and the pressure-sensitive adhesive of bound water gel 1 do not lump together; For preventing that hydrogel 1 from polluting; Cover release paper or film 4 (like release paper or mould release membrance) on the hydrogel 1 on the outer surface with the medical adhesive tape 3 of band pressure sensitive adhesive; After the mode of employing vacuum is sealed in it in packaging bag, the gamma-radiation sterilization.
[embodiment 2] are 200 g/m with specification
2Non-woven fabrics 2 use finite concentration Ag+ or nanometer silver solution to handle, be about to non-woven fabrics 2 and be immersed in the cross-linking agent solution, fixedly cross-linking agent makes Ag+ or the nano-silver ionic of having 0.5mol on every square metre of non-woven fabrics, dry for standby.Sodium alginate and carboxymethyl cellulose are made into 5% aqueous solution, are coated on the non-woven fabrics of handling well 2, left standstill 5-10 minute, hydrogel 1 crosslinked completion is combined into an integral body with 2 layers of non-woven fabrics.With this global transfer to the band pressure sensitive adhesive medical adhesive tape 3 on; 2 layers of the non-woven fabrics and the pressure-sensitive adhesive of bound water gel 1 do not lump together; Cover release paper or film 4 on the hydrogel 1 on the outer surface with the medical adhesive tape 3 of band pressure sensitive adhesive; It is packaged in the packaging bag that is full of nitrogen, sterilizes with gamma-radiation then.
Because silver ion or nano-silver ionic have very obvious sterilization effect, the aerogel dressing that adopts this mode to prepare has antibacterial preferably and bactericidal effect.
[embodiment 3] are 120 g/m with specification
2Non-woven fabrics 2 use finite concentration Fe
2+Or Fe
3+Solution-treated is about to non-woven fabrics 2 and is immersed in the cross-linking agent solution, and fixedly cross-linking agent makes the Fe of having 0.2mol on every square metre of non-woven fabrics 2
2+Or Fe
3+Ion, dry for standby.Sodium alginate and carboxymethyl chitosan are made into 6% aqueous solution, are coated on the non-woven fabrics of handling well 2, left standstill 5-10 minute, hydrogel 1 crosslinked completion is combined into an integral body with 2 layers of non-woven fabrics.With this global transfer to the band pressure sensitive adhesive medical adhesive tape 3 on; The nonwoven layer of bound water gel and pressure-sensitive adhesive do not lump together; Cover release paper or film 4 on the hydrogel on the outer surface with the medical adhesive tape 3 of band pressure sensitive adhesive; After adopting the mode of vacuum or inflated with nitrogen to be sealed in it in packaging bag, high pressure steam sterilization then.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. medical aquogel dressing, it is characterized in that: this dressing comprises hydrogel layer, non-woven fabrics and medical adhesive tape, on a face of said non-woven fabrics, is provided with hydrogel layer, this non-woven fabrics another side is bonded on the medical adhesive tape.
2. dressing according to claim 1 is characterized in that: contain a kind of or any several kinds mixing in sodium alginate, carboxymethyl cellulose, carboxymethyl chitosan, the hyaluronate sodium in the said hydrogel layer.
3. dressing according to claim 1 is characterized in that: the thickness of said hydrogel layer is 0.1mm～3 mm.
4. dressing according to claim 1 is characterized in that: be fixed with cross-linking agent on the said non-woven fabrics.
5. dressing according to claim 4 is characterized in that: said cross-linking agent comprises inorganic Ca
2+, Zn
2+, Fe
2+, Fe
3+, a kind of in Ag+ or the nano-silver ionic, and every square metre of non-woven fabrics is provided with the above-mentioned ion of 0.001～0.1 mol.
6. dressing according to claim 1 is characterized in that: said non-woven fabrics weight per unit area is than being 60g/m
2～200 g/m
2
7. dressing according to claim 1 is characterized in that: described medical adhesive tape is the PU film medical adhesive tape of waterproof and breathable.
8. the method for preparing of a medical aquogel dressing is characterized in that: non-woven fabrics is immersed in the cross-linking agent solution, and oven dry is fixed on the non-woven fabrics cross-linking agent; The hydrogel material solution is applied on the wherein one side of this non-woven fabrics, forms hydrogel layer, treat crosslinked completion after, the one side of the band pressure sensitive adhesive of the another side of this non-woven fabrics and medical adhesive tape is bonding; Enclose isolating membrane in hydrogel layer one side outwardly; After being sealed in aerogel dressing in the packaging bag, sterilization.
9. the method for preparing of dressing according to claim 8, it is characterized in that: the concentration of the hydrogel material solution of use is 0.5%～10% (percentage by weight).
10. the method for preparing of dressing according to claim 8, it is characterized in that: the sterilization method of this aerogel dressing is gamma-radiation, electron beam or high pressure steam sterilization.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210061210.2A CN102600019B (en) | 2012-03-09 | 2012-03-09 | Medical hydrogel dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210061210.2A CN102600019B (en) | 2012-03-09 | 2012-03-09 | Medical hydrogel dressing and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN102600019A true CN102600019A (en) | 2012-07-25 |
| CN102600019B CN102600019B (en) | 2014-04-09 |
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ID=46518053
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Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847196A (en) * | 2012-07-31 | 2013-01-02 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN103495199A (en) * | 2013-10-08 | 2014-01-08 | 山东赛克赛斯药业科技有限公司 | Hydrogel wound dressing for treating laser cauma and burns and scalds as well as preparation method thereof |
| WO2014032780A1 (en) * | 2012-08-28 | 2014-03-06 | University Of Geneva | Hybrid hydrogels |
| CN103623453A (en) * | 2013-12-06 | 2014-03-12 | 长春吉原生物科技有限公司 | Preparation method of silver ion hydrogel dressing |
| CN103768650A (en) * | 2014-01-26 | 2014-05-07 | 深圳市博立生物材料有限公司 | Wound regenerating and repairing bandage and manufacture method thereof |
| CN104069537A (en) * | 2014-07-17 | 2014-10-01 | 厦门大学 | Sodium alginate-sodium carboxymethylcellulose-chitosan wound dressing and preparation method thereof |
| CN104224446A (en) * | 2014-09-03 | 2014-12-24 | 常州好安生物科技有限公司 | Alginate adhesive bandage and manufacturing method of alginate adhesive bandage |
| CN104524619A (en) * | 2014-12-30 | 2015-04-22 | 东莞市鸿元医药科技有限公司 | Chitosan dressing and production process thereof |
| CN105056285A (en) * | 2015-09-23 | 2015-11-18 | 广东泰宝医疗科技股份有限公司 | Growth factor compound dressing capable of adhering tissue fissure and preparation method thereof |
| CN105079861A (en) * | 2015-09-09 | 2015-11-25 | 青岛高新区尚达医药研究所 | Preparation process of modified chitosan composite gel moisture retention adhesive bandage |
| CN105107008A (en) * | 2015-09-16 | 2015-12-02 | 中南民族大学 | Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster |
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| CN105288698A (en) * | 2015-11-19 | 2016-02-03 | 广东泰宝医疗科技股份有限公司 | Calcium alginate composite medical surgical dressing and preparation method thereof |
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| US20160206773A1 (en) * | 2015-01-20 | 2016-07-21 | Shaker A. Mousa | Composition and method for stopping hemorrhage, infection, and accelerating healing in various types of wound or burns |
| CN106110369A (en) * | 2016-06-30 | 2016-11-16 | 江苏开源康达医疗器械有限公司 | A kind of medical composite type hyaluronic acid dressing and preparation method thereof |
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