CN102755157A - Measuring method of finger tip blood flow rate and measuring instrument thereof - Google Patents
Measuring method of finger tip blood flow rate and measuring instrument thereof Download PDFInfo
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Abstract
本发明公开了一种基于加速脉搏波的指端血流速度测量方法及其测量仪器，该仪器包括容积脉搏波采集模块，信号调理模块，运算处理模块，外部大容量存储模块，USB通信模块，波形及结果显示模块。测量时，容积脉搏波传感器检测人体指端脉搏搏动信号，经信号调理模块后，通过运算处理模块转换为数字信号，并存储于外部大容量存储模块中，将容积脉搏波进行两次微分及滤波处理，得到平滑二次微分波形，即系统所需加速脉搏波；从加速脉搏波中，提取出脉搏波传导时间，建立传导时间与人体血压之间的函数关系，确定血流速度。本发明实现了无创，便捷，准确可靠的指端血流速度测量，测量仪器所需输入信号少，输入信号与测量结果间关系稳定。
The invention discloses a method for measuring fingertip blood flow velocity based on accelerated pulse waves and a measuring instrument thereof. The instrument includes a volumetric pulse wave acquisition module, a signal conditioning module, an operation processing module, an external large-capacity storage module, and a USB communication module. Waveform and result display module. During the measurement, the volume pulse wave sensor detects the pulse signal of the fingertips of the human body. After the signal conditioning module, it is converted into a digital signal by the operation processing module and stored in the external large-capacity storage module. The volume pulse wave is differentiated and filtered twice. Processing to obtain a smooth quadratic differential waveform, that is, the accelerated pulse wave required by the system; from the accelerated pulse wave, the pulse wave transit time is extracted, and the functional relationship between the transit time and human blood pressure is established to determine the blood flow velocity. The invention realizes non-invasive, convenient, accurate and reliable fingertip blood flow velocity measurement, requires less input signal for the measuring instrument, and has a stable relationship between the input signal and the measurement result.
Description
Technical field
The invention belongs to medical instruments field, relate in particular to a kind of the utilization and quicken measuring method and the gauge that the pulse wave extracting parameter calculates VPV.
Background technology
A lot of researchs show that blood flow parameter can well reflect body physiological state, have played very positive effect for the prevention and the treatment of a lot of diseases, and VPV then is one very important in each blood flow parameter.
At present the detection method of VPV is generally ultrasonic doppler and laser Doppler method, promptly utilizes ultrasonic or laser means will organize the inner blood image to be presented on the screen, reflects VPV through the variation of measuring blood image in the screen.Present most of hospital all has been equipped with doppler imaging VPV detector, is used for diagnosis and scientific research, and Doppler's method VPV detector has passed through improvement and the clinical practice of decades, is approved by numerous medical workers.
But because Doppler's method VPV detector volume is comparatively huge; Operation inconvenience and operator's know-how had relatively high expectations; Comparatively fixing for the test position, such as finger, as family; Scientific research places etc. need to have used with regard to being inconvenient under the situation of convenient and swift measure blood flow speed.
To sum up, at present the detection of VPV is still existed considerable restraint and deficiency when certain environment and the applications.
Summary of the invention
Technical problem to be solved by this invention provides a kind of noinvasive, and is convenient, accurately and reliably the measuring method of finger tip VPV and gauge thereof; This method required input signal is few; Relation is stable between input signal and measurement result, and it is little, easy and simple to handle that this gauge also has a volume; Relative low price is fit to family's detection and scientific research institution and uses.
In order to solve this technical problem, concrete technical scheme of the present invention is following:
A kind of measuring method of finger tip VPV, it may further comprise the steps:
(1) obtains the original faint light Power Capacity pulse wave signal of this object;
(2) the more level and smooth photoelectricity volume pulse wave signal of acquisition behind signal condition;
(3), after calculation process, obtain to quicken pulse and involve pulse wave translation time through the photoelectricity volume pulse wave signal after the conditioning;
(4) said live subject finger tip VPV and the pulse wave translation time function through setting up obtains the finger tip VPV.
To the pulse wave signal after conditioning that obtains, gather and store through calculation process module and outside high capacity memory module, and behind digital filtering, confirm the original volume pulse wave.
To the original volume pulse wave, carry out two subdifferentials and filtering through the calculation process module, obtain to quicken pulse wave.
To quickening pulse wave, quicken the identification of pulse wave characteristic point and catch through the calculation process module, and obtain conduction time through computing.
To conduction time, carry out match through the calculation process module, calculate, obtain VPV.
With original waveform, quicken pulse waveform and VPV calculating result and be shown in synchronously in the LCD liquid crystal display screen.
A kind of instrument of realizing finger tip blood flow velocity measurement method, it by:
Obtain the photoelectricity volume pulsation wave acquisition module of this live subject;
The photoelectricity volume pulsation wave that obtains is carried out the signal condition module of signal condition;
Conditioning postwave graphic data is carried out the calculation process module of calculation process;
To nursing one's health the outside high capacity memory module that the postwave graphic data is stored;
Conditioning postwave graphic data is carried out the usb communication module with compunication;
The waveform that Wave data and measurement result are shown and as a result display module form,
Volume pulsation wave acquisition module, signal condition module, calculation process module, usb communication sequence of modules connect, and in addition, the calculation process module also is connected with waveform and structure display module with the high capacity memory module.
The outfan of said calculation process module connects outside high capacity memory module respectively, usb communication module, waveform and display module as a result.
Said volume pulsation wave acquisition module comprises infrared light luminous tube and light-receiving tube, is used to obtain the original small-signal of said live subject finger end photoelectricity volume pulsation wave, and its outfan connects the signal condition module.
Said signal condition module comprises the two-stage amplifying circuit; Trap circuit and filter circuit suppress the baseline drift circuit, are used for the faint light Power Capacity pulse wave signal that collects is carried out suitable amplification; Filtering and signal condition, its outfan concatenation operation processing module.
Said calculation process module comprises the pulse wave signal collection, the differential processing module, and conduction time calculates, and is used for gathering nursing one's health the back signal, handles and the algorithm computing.
Said outside high capacity memory module comprises the interim storage of data in the calculation process and the permanent storage of operation result.
Said usb communication module comprises receiving orders and the transmission data, is used for realizing and compunication interactive information after above-mentioned initial data and the calculation process.
Said waveform and as a result display module comprise user interface, pulse wave shows and result of calculation shows.
Compared with prior art, instrument hardware of the present invention and profile are small and exquisite, extremely make things convenient in family and community medicine monitoring to use, and for early stage blood flow disease prevention, the important references physical signs are provided; Simultaneously, this instrumentation is convenient, detects fast, only needs holding finger, and the acquired volume pulse wave can be realized blood flow velocity measurement, the psychological burden when having reduced injury and the diagnostic detection outside patient's slight illness.
Description of drawings
Fig. 1 is an instrument The general frame of the present invention.
Fig. 2 is original pulse wave differential and filter effect figure among the present invention.
Fig. 3 is original pulse wave and acceleration pulse wave characteristic point mark figure among the present invention.
Fig. 4 is systolic pressure Ps and conduction time PWT correlation coefficient figure among the present invention.
Fig. 5 is diastolic pressure Pd and systolic pressure Ps correlation coefficient figure among the present invention.
Fig. 6 is the testing result correlation coefficient figure of system of the present invention.
The specific embodiment
Blood flow velocity measurement method disclosed by the invention can be used for the measurement of VPV, also can be used for the measurement of the blood flow relevant parameter relevant with pulse wave translation time, like blood pressure; SV; Cardiac output, Peripheral resistance, vascular compliance etc.; Below in conjunction with the concrete implementation of this measuring method of accompanying drawing explaination, accompanying drawing 1 is an instrument The general frame of the present invention.
Instrument of the present invention comprises volume pulsation wave acquisition module 2, signal condition module 6, calculation process module 8; Outside high capacity memory module 9, usb communication module 10, waveform and display module 11 as a result; Wherein, volume pulsation wave acquisition module 2, signal condition module 6 and calculation process module 8 are for being linked in sequence; Accomplish the collection of pulse wave signal, calculation process module 8 comprises the pulse wave signal collection that order is carried out, differential processing module; Slip mean filter module, conduction time searching and computing module, VPV calculates module.The outfan of calculation process module 8 connects outside high capacity memory module 9 respectively, usb communication module 10, and waveform and display module 11 are as a result realized the storage of pulse wave and result of calculation respectively, communication and Presentation Function.During detection, carry out as follows:
1, after the infrared light of launching from infraluminescence pipe 3 passes through human finger 1 transmission; Received the infrared light after being absorbed by infrared light receiving tube 4; Because blood can be beaten and the variation of pests occurrence rule property along with heart in the human finger 1 interior blood vessel at every turn; So catch this variation and be converted into the signal of telecommunication, promptly be original faint light Power Capacity pulse wave signal (5) through infrared light receiving tube 4.
2, the photoelectricity volume pulse wave signal 5 that obtains through device 2, atomic weak and with a lot of interfering signals, must carry out suitable amplification to it, interfering signal is removed in filtering.Photoelectricity volume pulse wave signal 5 at first amplifies suitable multiple through the one-level amplifying circuit; Again amplified signal is disturbed through 50Hz notch filter circuit filtering 50Hz power frequency; Then signal process after the filtering is suppressed the baseline drift circuit; To nurse one's health the back signal at last and amplify, obtain level and smooth effectively photoelectricity volume pulse wave signal 7 through secondary.
3, for the volume of the photoelectricity preferably pulse wave signal 7 that obtains; Carry out the digitized conversion of signal through calculation process module 8 inner A/D converters; Data are carried out calculation process; Calculate pulse wave translation time, finally calculate the VPV value, and waveshape signal and result of calculation are stored in the outside high capacity memory module 9.
4, can upload to computer through usb communication module 10 for the data that are stored in the outside high capacity memory module 9, the analysis and the instrument maintenance in later stage that are used for the experimental stage data upgrade.
5, VPV value that calculates through the calculation process module and pulse waveform data can through waveform and as a result display module 11 show.
6, calculation process module 8 is the core processor of whole system; Be responsible for comprising the collection of data, storage, communication and the control that shows; What is more important is carried out the realization of operation processing function to the data that collect, and this calculation process process mainly comprises following step:
A. volume pulsation wave datum after the conditioning that collects 7 is carried out digital filtering, further filtering interfering obtains the preceding original volume pulse wave I of differentiating, like Fig. 2;
B. for the top original volume pulse wave that obtains, carry out the first order differential computing, take digital filtering mode equally, remove the burr that produces behind the differential, make the data smoothing after the first order differential, obtain pulse wave II after the first order differential, like Fig. 2;
C. for pulse wave II after the top first order differential that obtains, carry out the second-order differential computing, adopt digital filtering mode; Remove the burr that produces behind the second differential, make the data smoothing behind the second-order differential, obtain pulse wave behind the second-order differential; Be the acceleration pulse wave III that system needs, like Fig. 2;
D. like Fig. 3; From original volume pulse wave and acceleration pulse wave map; Can see very clearly that quickening pulse wave appears and very clocklike rise and descends, these upstroke and decent can well explain that blood that heartbeat causes bursts out the variation relation with blood backflow and blood vessel, and wherein A-C section interval can reflect more accurately that blood is put out from heart and is passed to the required time of distal finger blood capillary; And research shows at present; This interval and human body artery blood pressure have good linear relationship, therefore, can from quicken pulse wave, obtain pulse wave translation time PWT.
7, the linear relationship that exists between arteriotony and the conduction time can be represented through following linear equation:
Ps=a*PWT+b
Pd=c*Ps+d
Wherein, a, b, c, d are fitting coefficient,
Ps, Pd are respectively systolic pressure (mmHg) and diastolic pressure (mmHg),
PWT is conduction time (ms),
K=wave character amount gets constant,
S=vascular cross-section amasss (mm
2), get constant 500,
Bv=VPV (cm/s),
Obtain VPV Bv functional relationship through deriving:
Bv=m*PWT+n
Wherein, m, n are correction factor.
8, behind 85 volunteer pulse wave data compilations, draw out conduction time and arteriotony correlation coefficient figure to collection, like Fig. 4,5, and the testing result correlation coefficient figure of system of the present invention, like Fig. 6.
Claims (8)
1. the measuring method of a finger tip VPV is characterized in that: comprise the steps:
(1) obtains the original faint light Power Capacity pulse wave signal of this object;
(2) the more level and smooth photoelectricity volume pulse wave signal of acquisition behind signal condition;
(3), after calculation process, obtain to quicken pulse and involve pulse wave translation time through the photoelectricity volume pulse wave signal after the conditioning;
(4) said live subject finger tip VPV and the pulse wave translation time function through setting up obtains the finger tip VPV.
2. the gauge of a finger tip VPV is characterized in that: it by:
Obtain the photoelectricity volume pulsation wave acquisition module (2) of this live subject;
The photoelectricity volume pulsation wave that obtains is carried out the signal condition module (6) of signal condition;
Conditioning postwave graphic data is carried out the calculation process module (8) of calculation process;
To nursing one's health the outside high capacity memory module (9) that the postwave graphic data is stored;
Conditioning postwave graphic data is carried out the usb communication module (10) with compunication;
The waveform that Wave data and measurement result are shown and as a result display module (11) form,
Volume pulsation wave acquisition module (2), signal condition module (6), calculation process module (8), usb communication module (10) are linked in sequence; In addition, calculation process module (8) also is connected with waveform and structure display module (11) with high capacity memory module (9).
3. according to the gauge of claim 2; It is characterized in that: said volume pulsation wave acquisition module (2); It is the volume pulsation pick off; Obtain the original small-signal of said live subject finger end photoelectricity volume pulsation wave, comprise medical blood oxygen probe, outfan connects the amplifying circuit of signal condition module (6).
4. according to the gauge of claim 2, it is characterized in that: said signal condition module (6) is the small-signal modulate circuit; Faint light Power Capacity pulse wave signal to collecting carries out suitable amplification; Filtering and signal condition comprise the two-stage amplifying circuit of unidirectional connection in proper order, trap circuit and filter circuit; Suppress the baseline drift circuit, its outfan concatenation operation processing module (8).
5. according to the gauge of claim 2, it is characterized in that: said calculation process module (8) is an arithmetic processing circuit; Gather nursing one's health the back signal, handle and the algorithm computing, comprise the pulse wave signal collection that order is carried out; The differential processing module; Slip mean filter module, conduction time searching and computing module, VPV calculates module.
6. according to the gauge of claim 2, it is characterized in that: said outside high capacity memory module (9) is outside high capacity memory circuit, to the interim storage of data in the above-mentioned calculation process and the permanent storage of operation result.
7. according to the gauge of claim 2, it is characterized in that: said usb communication module (10) is the usb communication circuit, to realizing and compunication interactive information, instrument updating maintenance after above-mentioned initial data and the calculation process.
8. according to the gauge of claim 2, it is characterized in that: said waveform and display module (11) as a result are the LCD display circuits, with the interface display of the result after waveform that collects and the calculation process in demonstration and user's operating process of lcd screen.
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| CN107714003A (en) * | 2017-09-30 | 2018-02-23 | 天津大学 | A kind of fingertip pulse wave detector based on flexible PIN photodiode |
| CN107863156A (en) * | 2017-12-26 | 2018-03-30 | 桂林电子科技大学 | A kind of hypertension examination and management method and device |
| CN108175387A (en) * | 2017-12-19 | 2018-06-19 | 桂林电子科技大学 | A kind of peripheral vascular resistance detection device and detection method based on electrocardio and pulse wave Morphologic Parameters |
| CN109157224A (en) * | 2018-06-06 | 2019-01-08 | 电子科技大学 | A kind of pulse blood oxygen monitoring system and method increasing reference light source calibration |
| CN109222924A (en) * | 2018-11-05 | 2019-01-18 | 广州丰谱信息技术有限公司 | Cardiovascular property non-invasive quantitative assessment method and device based on acousto-optic combined spectrum |
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| CN109770886A (en) * | 2019-01-03 | 2019-05-21 | 中国科学院半导体研究所 | Flexible and stickable blood flow velocity test system and construction method thereof |
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| CN107714003A (en) * | 2017-09-30 | 2018-02-23 | 天津大学 | A kind of fingertip pulse wave detector based on flexible PIN photodiode |
| CN108175387A (en) * | 2017-12-19 | 2018-06-19 | 桂林电子科技大学 | A kind of peripheral vascular resistance detection device and detection method based on electrocardio and pulse wave Morphologic Parameters |
| CN107863156A (en) * | 2017-12-26 | 2018-03-30 | 桂林电子科技大学 | A kind of hypertension examination and management method and device |
| CN109157224A (en) * | 2018-06-06 | 2019-01-08 | 电子科技大学 | A kind of pulse blood oxygen monitoring system and method increasing reference light source calibration |
| CN109512403A (en) * | 2018-11-05 | 2019-03-26 | 北京招通致晟科技有限公司 | A kind of finger tip photoplethysmographic detection method, equipment and system |
| CN109512403B (en) * | 2018-11-05 | 2021-11-26 | 北京招通致晟科技有限公司 | Finger tip photoelectric volume pulse wave detection method, device and system |
| CN109222924A (en) * | 2018-11-05 | 2019-01-18 | 广州丰谱信息技术有限公司 | Cardiovascular property non-invasive quantitative assessment method and device based on acousto-optic combined spectrum |
| CN109770886B (en) * | 2019-01-03 | 2022-10-11 | 中国科学院半导体研究所 | Flexible attachable blood flow velocity testing system and construction method thereof |
| CN109770886A (en) * | 2019-01-03 | 2019-05-21 | 中国科学院半导体研究所 | Flexible and stickable blood flow velocity test system and construction method thereof |
| CN114081482A (en) * | 2021-11-23 | 2022-02-25 | 电子科技大学 | A method and device for detecting blood glucose concentration based on waveform evidence regression |
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