CN102911076B - Treatment unit after acetparaminosalol phenol treating and treatment process thereof - Google Patents

Abstract

The invention provides a treatment device and a treatment method for refined acetaminophen. The processing device includes: a feeding tank connected with the outlet of the crystallization tank, receiving and stirring the materials produced from the crystallization tank; a bottom discharge centrifuge connected with the outlet of the feeding tank; The loading equipment below the unloading centrifuge, the lower unloading centrifuge unloads the centrifuged material to the loading equipment; it is connected to the loading equipment to dry the material from the loading equipment a vibrating fluidized bed; and a pulverizer connected with the vibrating fluidized bed to pulverize the materials introduced by the vibration of the vibrating fluidized bed. The processing device and processing method of the present invention realize continuous production, meet the requirements of clean production, avoid cross-contamination, reduce labor intensity of workers, save labor, increase batches of finished products, and reduce laboratory costs.

Description

Treatment device and treatment method for refined acetaminophen

technical field

The invention relates to a device and a method in the production process of acetaminophen, in particular to a treatment device and a treatment method for refined acetaminophen.

Background technique

In the current production and refining process of acetaminophen, since the output of acetaminophen is generally relatively large, there is often not one refining crystallization tank, but multiple. In the traditional way, the refined and crystallized material passes through multiple small After the centrifuge is dried, it is loaded into the feeding truck, and then transported by the workers to the drying equipment for drying by manual loading. The dried materials are then loaded into the feeding truck and transported to the crusher for crushing by manual feeding, and then packaged. . In this process, the labor intensity of the workers is high, and they cannot work continuously, and the dust of the dried materials is very polluting to the environment, which cannot meet the requirements of clean production, and cross-contamination is inevitable.

Furthermore, the batch of finished products from a single refined crystallization tank is relatively small, and the finished products from each refined crystallization tank should be tested separately. Because the quantity of refined crystallization tanks is generally more than one but multiple, this results in a large number of testing times and high costs. High, so the cost is not easy to control.

Contents of the invention

The purpose of the present invention is to overcome the above-mentioned technical problems and provide a treatment device and a treatment method for refined acetaminophen. The present invention realizes continuous production and meets the requirements of clean production by improving the equipment and optimizing the process. , avoiding cross-contamination, reducing the labor intensity of workers, saving labor, increasing the batch size of finished products, and reducing the cost of testing.

The treatment device after the paracetamol refining provided by the present invention comprises:

A feeding tank that is connected with the outlet of the crystallization tank, receives and stirs the material produced from the crystallization tank;

A lower discharge centrifuge connected to the outlet of the feeding tank;

A charging device arranged below the lower discharge centrifuge, the lower discharge centrifuge discharges the centrifuged material to the charging device;

a vibrating fluidized bed connected to said charging device for drying material from the charging device; and

Connected with the vibrating fluidized bed, it is a pulverizer for pulverizing the materials introduced by the vibration of the vibrating fluidized bed.

The material in the crystallization tank can be pumped into the feeding tank.

The charging device and the vibrating fluidized bed may be sealed and connected through a pipeline arranged above the charging device. For example, hoses can be used to seal the connection.

The vibrating fluidized bed and the pulverizer may be connected in a sealed manner, and may be connected through a stainless steel pipe. Sealed connections can reduce cross-contamination and meet the requirements of clean production.

There are at least two crystallization tanks, and the number of crystallization tanks can be determined according to the volume of the feeding tank. For example, when the volume of the feeding tank is 2.4 times the volume of the crystallizing tank, there can be two crystallizing tanks, and the refined materials of the two crystallizing tanks can be introduced into the feeding tank at the same time, thereby increasing the batch size of the product.

The bottom discharge centrifuge is manual or fully automatic, and the present invention is preferably a fully automatic scraper bottom discharge centrifuge.

The present invention can use vacuum to draw the material on the charging device into the vibrating fluidized bed. For example, a vacuuming device is provided between the vibrating fluidized bed and the charging device.

The charging equipment can be selected from commonly used feeding carts and the like.

The treatment method after the paracetamol refining provided by the present invention adopts the above-mentioned treatment device, and comprises the following steps:

The step of pumping the refined and crystallized material in at least one crystallization tank into the feeding tank;

After the material is stirred in the feeding tank, centrifuging through the lower discharge centrifuge and discharging to the charging equipment arranged below the lower discharge centrifuge;

pumping the material in the charging device to a vibrating fluidized bed for drying by vacuum, and then using the vibration of the vibrating fluidized bed to transport the material to a pulverizer;

A step of transporting the material powder pulverized by the pulverizer to a packaging process for packaging.

Beneficial effects of the present invention: the device realizes continuous work, and there is no need for manual loading, loading, and transportation between several processing procedures after the paracetamol is refined, which greatly reduces the labor intensity of workers; in addition, the device Sealed connecting parts are used to connect the drying equipment and the pulverizer to avoid the pollution of the dried material dust to the environment, so that it meets the requirements of clean production and avoids cross-contamination. In addition, the device introduces the equipment of feeding tank, which can make the materials in multiple crystallization tanks be mixed into one batch before centrifugation, thereby increasing the batch size of finished products, which is equivalent to eliminating the corresponding batch mixing machine. At the same time, the number of tests is reduced, and the cost is reduced, thereby reducing the production cost.

Description of drawings

Fig. 1 is a schematic diagram of a treatment device after paracetamol is refined in a preferred embodiment of the present invention.

Fig. 2 is the structural representation of the mixed batch machine that prior art adopts.

Wherein, the reference signs are explained as follows:

1: crystallization tank; 2: feeding tank; 3: automatic scraper discharge centrifuge; 4: feeding truck; 41: hose; 5: vibrating fluidized bed; 51: stainless steel tube; 6: pulverizer.

Detailed ways

The treatment device and treatment method of paracetamol after refining of the present invention will be described below in conjunction with the accompanying drawings.

First, the processing apparatus after the purification of acetaminophen in a preferred embodiment of the present invention will be described.

Fig. 1 is a schematic diagram of a treatment device after paracetamol is refined in a preferred embodiment of the present invention.

As shown in Figure 1, the treatment device after paracetamol refining in this preferred embodiment includes: connected to the outlet of one or more crystallization tanks 1, receiving and stirring the material produced from the crystallization tank 1 Feeding tank 2; the scraper discharge centrifuge 3 connected to the outlet of the feed tank 2; the feed truck 4 arranged below the scraper discharge centrifuge 3, the scraper discharge centrifuge 3. Unload the material in the feeding tank 2 to the feed truck 4; the vibrating fluidized bed 5 is connected to the feed truck 4, and the material in the feed truck 4 is sucked in by vacuum for drying; The pulverizer 6 is connected with the vibrating fluidized bed 5, and the material is introduced into the pulverizer 6 at a uniform speed through the vibration of the vibrating fluidized bed 5, and then the material is pulverized, and finally the pulverized material is packaged, assay.

The way that the material enters the feeding tank 2 from the crystallization tank 1 can be sent into the feeding tank 2 under the action of a pump, or it can be other feasible ways. As a centrifuge with discharge under the scraper, it can be a fully automatic model or a manual model, which is determined according to actual needs.

In addition, the skip 4 and the vibrating fluidized bed 5 are sealed and connected through a pipeline arranged above the skip 4 , preferably through a hose 41 . The reason why the sealed pipeline is adopted is that the material on the skip truck 4 will be sucked into the vibrating fluidized bed 5 by vacuum. For this reason, it is necessary to install a vacuuming device between the skip truck 4 and the vibrating fluidized bed to connect with the above-mentioned pipelines, so as to transport materials between the skip truck 4 and the vibrating fluidized bed 5 by using vacuum.

Of course, if the suction force of the fan is large enough, the fan can also be used to transport the material from the feed truck 4 to the vibrating fluidized bed 5 .

In addition, the connection between the vibrating fluidized bed 5 and the pulverizer 6 is sealed through a stainless steel pipe 51, thereby avoiding the pollution of the dried material dust to the environment, making it meet the requirements of clean production, and also Cross-contamination is avoided.

The crystallization tank 1 is not limited to one, and there may be multiple crystallization tanks. In this embodiment, two crystallization tanks are provided. When there are two or more crystallization tanks, that is to say, when the materials produced by multiple crystallization tanks are stored in the feeding tank 2, the feeding tank is equivalent to a transfer tank, and multiple crystallization tanks can be The materials produced in the tank are mixed in it to form a batch, so that the batch of finished products becomes larger, which saves a batch mixing machine and also saves the cost of testing. If the refined acetaminophen is processed in the traditional way, it will take The finished products of each refining crystallization tank are tested separately, and the processing device of the present invention is adopted, because the materials from a plurality of refining crystallization tanks are first mixed and then centrifuged, dried, and pulverized, which reduces the batches that need to be tested. The output of each batch is increased, so the cost of testing is reduced.

The following is a detailed analysis of the advantages of using a feeding tank for material mixing in the present invention compared to using a batch mixer in the prior art.

In the prior art, the mixed batch machine is used to mix the materials produced in different batches after the centrifugation and drying process (that is, in the vibrating fluidized bed 5). The structural diagram of the mixed batch machine is shown in Figure 2, which is to put The double-conical stainless steel tank is placed on a large bracket, and the dried materials are placed inside, then the lid is closed, and the crankshaft is used to reciprocate, thereby mixing the dry materials put into the tank.

The present invention uses feeding tanks 2 directly behind multiple crystallization tanks 1 to mix different batches of materials together, and then centrifuges, dries and other processes after mixing evenly by stirring.

The existing technology of using a batch mixing machine is to mix the dry materials. Since the materials are evenly mixed by turning the tank upside down, a large amount of dust is produced due to friction between the dry materials (causing Dust increases near the working area of the mixed batch machine, and the dust will also increase during packaging, which will have a negative impact on the working environment of the operators).

However, the feeding tank of the present invention directly receives the material from the crystallization tank, and the material at this time is liquid, and the objects in the tank are mixed by stirring (the tank body is provided with an agitator), so reducing It reduces the generation of dust and improves the working environment of workers.

Moreover, from the point of view of the effect of stirring, the stirring and mixing of liquids from different batches (crystallization tanks) should be better than the mixing of solids from different batches, that is, the mixing should be more uniform.

Moreover, compared with the feeding tank, the mixed batch machine is not only expensive but also needs a larger area of space, so the way of using the feeding tank not only saves the cost but also reduces the requirements for the site. The treatment method of paracetamol after refining is described below by using the treatment device in the preferred embodiment of the present invention.

The refined and crystallized material of the two crystallization tanks 1 is pumped into the feeding tank 2 (its volume is equivalent to 2.4 times the volume of the crystallization tank 1), and the material is stirred in the feeding tank 2, after that, Through the centrifugation of the full-automatic scraper discharge centrifuge 3 (the effect of the centrifuge is to separate the solid from the liquid, because the common three-legged centrifuge needs manual discharge from the upper part, so in order to reduce the labor intensity of workers, The centrifuge used here is fully automatic, does not require manual work, and can automatically discharge the material from the lower part) and automatically discharges to the material truck 4 arranged below it, and then the material in the material truck 4 is vacuumed Pumped into the vibrating fluidized bed 5 for drying (the reason why the material after the centrifuge 3 centrifugation is not directly sent into the fluidized bed 5 through the feed truck 4 is because the material in the feeding tank 2 cannot be used once After shaking, it takes several times to finish shaking. If the material is directly unloaded into the fluidized bed, continuous work cannot be guaranteed), and then the material is transported to the pulverizer 6 at a uniform speed by using the shaking of the vibrating fluidized bed 5, and finally The material powder pulverized by the pulverizer is transported to the packaging section for packaging.

Claims (5)

1. the treatment unit after acetparaminosalol phenol treating, is characterized in that, comprising:

Be connected with the outlet of at least two crystallizers, receive and stir the feed tank of the material from described at least two crystallizer outputs; Agitator is provided with in the tank body of described feed tank;

The lower discharging centrifuge be connected with the outlet of described feed tank;

Be arranged at the loading device below described lower discharging centrifuge, described lower discharging centrifuge by the material discharging after centrifugal to described loading device;

Be connected with described loading device, dry vibrated fluidized bed is carried out to the material from institute's loading device; And

Be connected with described vibrated fluidized bed, the pulverizer that the material introduced the vibration by described vibrated fluidized bed is pulverized,

Described material utilizes pump to squeeze into described feed tank from described at least two crystallizers;

Described loading device and described vibrated fluidized bed are connected by the seal for pipe joints be arranged on above described loading device;

Material on described loading device utilizes vacuum to be pumped on described vibrated fluidized bed.

2. the treatment unit after acetparaminosalol phenol treating as claimed in claim 1, is characterized in that,

Described vibrated fluidized bed and described pulverizer are tightly connected.

3. the treatment unit after acetparaminosalol phenol treating as claimed in claim 1, is characterized in that,

Described lower discharging centrifuge is full-automatic scraper lower discharging centrifuge.

4. the treatment process after acetparaminosalol phenol treating, is characterized in that, comprises following operation steps:

Material after at least two crystallizer refining crystallizations is squeezed into the step of feed tank by pump;

Carry out the stirring of described material in described feed tank after, by lower discharging centrifuge, centrifugal and discharging is to the step of the loading device be arranged on below described lower discharging centrifuge; Agitator is provided with in the tank body of described feed tank;

By vacuum the material in described loading device is extracted on vibrated fluidized bed and carries out drying, utilize the shake of described vibrated fluidized bed by the step of described mass transport to pulverizer afterwards;

Material powders after being pulverized by described pulverizer is transported to the step that packaging process carries out packing.

5. the treatment process after acetparaminosalol phenol treating as claimed in claim 4, is characterized in that,

Described lower discharging centrifuge is full-automatic scraper lower discharging centrifuge.