CN102920859B - Medicine for preventing pollen allergy - Google Patents
Medicine for preventing pollen allergy Download PDFInfo
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- CN102920859B CN102920859B CN201210467729.0A CN201210467729A CN102920859B CN 102920859 B CN102920859 B CN 102920859B CN 201210467729 A CN201210467729 A CN 201210467729A CN 102920859 B CN102920859 B CN 102920859B
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Abstract
The invention discloses a medicine for preventing pouen allergy, and aims to solve the problem of pouen allergy prevention. The medicine is characterized by comprising a plurality of traditional Chinese medicines as raw materials in parts by weight, wherein the raw materials are processed according to the following formula: 6 to 10 parts of didissandra, 8 to 15 parts of pteridium aquilinum, 8 to 15 parts of aralia mandshrica, 6 to 10 parts of retinervus luffae fructus, 6 to 10 parts of lindera erythrocarpa makino, 8 to 15 parts of ficus pumila, 6 to 10 parts of flos lonicerae, 8 to 15 parts of flos eriocauli and 3 to 6 parts of gryllotalpa. The clinical tests prove that the medicine provided by the invention has the characteristics of good efficacy and higher safety, so that the medicine has a clinical application and popularization value.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine that prevents pollen hypersensitivity.
Background technology
Pollen hypersensitivity is again pollinosis, belongs to a kind of anaphylactic disease, and main manifestations is three kinds of forms: pollen hypersensitivity rhinitis, pollen hypersensitivity asthma, pollen hypersensitivity membranous conjunctivitis.And so-called allergy is a kind of allergy of body, be people to a kind of abnormal response of koinomatter (anaphylactogen), only have when anaphylactogen touches the crowd of allergic constitution and just anaphylaxis can occur.At nature, pollen is a kind of main sensitinogen.When during the warmth of spring, all the flowers bloom, the most easily cause the seed tree that mostly is of pollen hypersensitivity, as root of Broussonetiapapyrifera(I)vent, Semen Ricini, Fructus Kochiae, oriental plane tree etc.These plant pollen amounts are large, volume is little, and in air, content is high, and the date of rising at wind more easily propagates, so occur that pollen hypersensitivity person is more during spring.In human body, having two class cells is mastocyte and basophil, and they are distributed widely in around the blood capillary in nasal mucosa, the intestines and stomach mucosa and skin lower floor connective tissue and in the peplos of internal organs.In this two classes cell, contain the Anaphylactic mediators such as histamine, leukotriene, 5-hydroxy tryptamine, kassinin kinin.In the envirment factors such as chemical substance, air pollution, solar irradiation stimulate lower body, can produce a large amount of free radicals, after free-radical oxidation, fail to remove in time, will destroy the cell membrane of mastocyte and basophil, make cell membrane degeneration cause cell unstable.After the oil containing in pollen and polysaccharide material are sucked by people, can be digested by the secretions of nasal cavity, discharge subsequently ten plurality of antigens.When unstable cell runs into after these antigens, antigen and antibody generation specific reaction, cause cell membrane to depart from, and discharges Anaphylactic mediator.Anaphylactic mediator can cause that thereby smooth muscle contraction, telangiectasis, permeability enhancing, mucous secretion and tissue injury cause anaphylactoid generation.In anaphylactoid generating process, Anaphylactic mediator plays direct effect, and anaphylactogen is the exopathogenic factor that irritated disease occurs, and body immunity is low, and the Oxidative demage of a large amount of radical pair mastocytes and basophilic leukocyte is the irritated endogenous cause of ill occurring.
In recent years, crowd's quantity of pollen hypersensitivity increases, except allergic constitution Susceptible population, also there is to pollen hypersensitivity symptom in the not irritated crowd of pollen in the past, its main cause has two aspects: be the raising due to people's living standard on the one hand, taken in high protein, the high caloric diets such as a large amount of eggs, meat products in diet, result causes the ability of generation antibody in body hyperfunction, thereby while running into the antigens such as pollen, just more easily there is allergy.Be because the extensive application of atmospheric pollution, water pollution and food additive causes human body to contact more antigenic substance on the other hand, impel the mankind that allergic disease occurs.
The treating method of pollen hypersensitivity is mainly to avoid contact and symptomatic treatment at present, the former mainly refers to occupy indoor at morbidity season, close the doors and windows to reduce entering of outdoor pollen, or go out by being branded as, mask and wear the medicated clothing of long sleeves, avoid directly contacting with pollen as far as possible, the latter mainly refers to use drug desensitization, as antihistaminics such as chlorphenamines, hismanal, quick gram, clarityne.For preventive usage, a kind of is to take antihistamine drug to use and prevent in advance, antihistamine drug can temporarily solve allergic symptom, but the irritated basis occurring does not change, under anaphylactogen stimulates, Anaphylactic mediator, still in continuous release, is not there is no allergy, but irritated symptom was covered in the very first time, so antihistamine drug need to be taken easily sending out season long irritated, side effect is large; Another kind of mode is to use in advance hormone for severe allergy asthmatic patient, to reduce antigen antibody reaction, mitigation symptoms, but the immunosuppressive action of hormone, have very large side effect, applicable surface is narrow, and the special population such as child, pregnant and lying-in women is used limited.Above two kinds of methods, antihistamine drug and hormone itself just can allow patient's regulatory mechanism burden heavier, seriously disturbed the originally accurate endocrine system of patient, also cause the imbalance of patient's normal intestinal flora, further the normal absorption of the sick HE absorption function of impact, vitamin, various trace element is affected, dissimilar substances easily absorbs in body, makes patient enter a vicious cycle, and the drug withdrawal state of an illness just repeatedly.This allopathic counter productive, has been recognized by increasing patient and clinician now.For a long time, traditional medicine circle does not all find the effective ways of radical cure anaphylactic disease, the effect of relief of symptoms is just played in a large amount of antihistaminics, the utilization of hormone medicine, and side effect is very big, especially the growth of infant, children and adolescents is had to great impact.Irritated patient is relief of symptoms in each outbreak repeatedly year in year out, and the immunocompetence of health is increasingly lowly very painful.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly, and the medicine of the little prevention pollen hypersensitivity of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of medicine that prevents pollen hypersensitivity, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of funnel lettuce tongues, 8 ~ 15 parts of Herba Fimbristylis dichotomae, 8 ~ 15 parts of Aralia mandshuricas, 6 ~ 10 parts of Retinervus Luffae Fructuss, fragrant 6 ~ 10 parts of Zhan's sugar, 8 ~ 15 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 6 ~ 10 parts of Flos Loniceraes, 8 ~ 15 parts of Flos Eriocaulis, 3 ~ 6 parts of Gryllotalpas.
Its optimum weight proportioning is: 8 parts of funnel lettuce tongues, 10 parts of Herba Fimbristylis dichotomae, 10 parts of Aralia mandshuricas, 8 parts of Retinervus Luffae Fructuss, fragrant 8 parts of Zhan's sugar, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 8 parts of Flos Loniceraes, 10 parts of Flos Eriocaulis, 5 parts of Gryllotalpas.
Wherein said: funnel lettuce tongue, for Gesneriaceae funnel lettuce tongue Didissandra sinoophiorrhizoides W. T. Wang, with root, be used as medicine.Nature and flavor are puckery, flat.Merit can be stopped blooding, cough-relieving, dampness removing, analgesia.
Herba Fimbristylis dichotomae, for fern Pteridaceae Herba Fimbristylis dichotomae Pteridium revolutum (Blume) Nakai, is used as medicine with root stock.Nature and flavor are micro-puckery; Sweet; Cool.Merit can heat-clearing and toxic substances removing; Expelling wind and removing dampness; Relieving stranguria by diuresis; Anthelmintic.
Aralia mandshurica, for Wu Jia Ke Cortex araliae chinensis platymiscium Liao Dong Cortex araliae chinensis Aralia elata (Miq.) Seem., is used as medicine with root bark.Nature and flavor are sweet, bitter, flat.Merit can stomach invigorating, diuretic, expelling wind and removing dampness, promoting blood circulation and stopping pain.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, and dispels the wind.
Zhan's sugar is fragrant, is bark or the leaf of canella Cortex Linderae Fragrantis Lindera erythrocarpa Makinl.Nature and flavor are pungent; Tepor.Merit can expelling wind and removing dampness; Removing toxic substances parasite killing.
Caulis fici pumilae (Fructus Fici Pumilae) is stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae) Ficus pumila L..Sour in the mouth, cool in nature.Merit can expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.
Flos Lonicerae is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or the flower that band is just opened.Nature and flavor are sweet, cold.Enter lung, stomach, the heart, spleen channel.Merit can heat-clearing and toxic substances removing, wind-heat dissipating.
Flos Eriocauli is scape or the herb of Eriocaulaceae plant Flos Eriocauli Eriocaulon buergerianum Koern..Nature and flavor are sweet, flat.Enter liver, stomach warp.Merit can dispelling wind and heat pathogens, improving acuity of vision and removing nebula.
Gryllotalpa, the adult of Gryllotalpidae insecticide Gryllotalpa Gryllotalpa africana Palisot et Beaurois or large Gryllotalpa G. unispina Saussure is all.Nature and flavor are salty, cold.Return bladder, large intestine, small intestine meridian.Merit can inducing diuresis to remove edema.
Composition principle: the reason of some patients were pollen hypersensitivity is allergic constitution, and separately there are some patients, are the incoherent emerging allergic symptoms of body constitution, its immanent cause is external antigen variation, cause the new antibody of generation in body, and this antibody and pollen antigen can produce antigen antibody reaction, excite allergy, cause allergic symptom.Current prevention, or take stopgap measures, also adopt antihistamine drug to carry out symptom control; Or with hormone, suppress organism immune response, but this immunosuppressant is non-selectivity, easily causes the health resistivity decline of various infective pathogen bodies to external world, lose more than gain.Prescription of the present invention passes through the adjustment to body self, promoting flow of QI and blood dredging collateral, and when changing this endogenous cause of ill of body constitution, expelling wind and removing dampness, heat-clearing and toxic substances removing, to remove pathogenic exopathogenic factor, play the effect of prevention.
Compared with the prior art, prescription is unique, has following characteristics in the present invention:
1, remove endogenous cause of ill: funnel lettuce tongue, Herba Fimbristylis dichotomae, this three herbal medicine of Aralia mandshurica share, can regulate intracellular balance, the effectively anaphylaxis of prevention pollen hypersensitivity, its collocation is to improve body itself, reduce body sensitivity, and this kind of effect have specificity, may to resist the antigen antibody reaction that pollen brings relevant to selectivity, irrelevant with antihistamine approach, can normally immunity of interference body;
2, remove exopathogenic factor: Zhan's sugar is fragrant, Caulis fici pumilae (Fructus Fici Pumilae) expelling wind and removing dampness, in order to strengthen removing ailment said due to cold or exposure, this two classes paathogenic factor of damp;
3, Retinervus Luffae Fructus, Caulis fici pumilae (Fructus Fici Pumilae) dredging collateral are invigorated blood circulation, and add blood medicine in prescription, assist in removing blood dry, and this two medicine has active effect, and anaphylactic disease belongs to defends surface diseases, adds active medicine, also has the effect of tying-in, and a medicine is multiplex, reduce the interference to body;
4, Flos Lonicerae, Flos Eriocauli dispelling wind and heat pathogens, while Flos Eriocauli can also draw all medicines and go upward to women's head-ornaments, and Flos Eriocauli also has benifit for pollen hypersensitivity membranous conjunctivitis;
5, Gryllotalpa, itself is as foreign protein, and acting as with because of same use in we, specifically, utilizes the stimulation body of suitable foreign protein appropriateness exactly; Chinese medicine Drug Prepared from Insects kind is numerous and diverse, the Gryllotalpa that inventor's clinical experience gained is for many years chosen under dosage of the present invention enters water decoction with decocting processing, in Gryllotalpa body tissue, contain 15 seed amino acids and multiple protein enzyme, with other foreign protein comparisons, its effect is best, and under dosage of the present invention, take with other drug together decocting to use be also safe, can't produce toxic and side effects;
6, the present invention does not adopt lung heat clearing or sensible medicine, and its meaning is: the object of the invention is to prevent the appearance of pollen hypersensitivity, rather than treat the allergic symptom that pollen hypersensitivity is brought, simplify medicine, reduced gastrointestinal is stimulated;
7, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: funnel lettuce tongue 6g, Herba Fimbristylis dichotomae 8g, Aralia mandshurica 8g, Retinervus Luffae Fructus 6g, the fragrant 6g of Zhan's sugar, Caulis fici pumilae (Fructus Fici Pumilae) 8g, Flos Lonicerae 6g, Flos Eriocauli 8g, Gryllotalpa 3g.
Embodiment 2, crude drug weight proportion: funnel lettuce tongue 10g, Herba Fimbristylis dichotomae 15g, Aralia mandshurica 15g, Retinervus Luffae Fructus 10g, the fragrant 10g of Zhan's sugar, Caulis fici pumilae (Fructus Fici Pumilae) 15g, Flos Lonicerae 10g, Flos Eriocauli 15g, Gryllotalpa 6g.
Embodiment 3, crude drug weight proportion: funnel lettuce tongue 8g, Herba Fimbristylis dichotomae 10g, Aralia mandshurica 10g, Retinervus Luffae Fructus 8g, the fragrant 8g of Zhan's sugar, Caulis fici pumilae (Fructus Fici Pumilae) 10g, Flos Lonicerae 8g, Flos Eriocauli 10g, Gryllotalpa 5g.
During use, Chinese medicine funnel lettuce tongue of the present invention, Herba Fimbristylis dichotomae, Aralia mandshurica, Retinervus Luffae Fructus, Zhan's sugar perfume, Caulis fici pumilae (Fructus Fici Pumilae), Flos Lonicerae, Gryllotalpa and Flos Eriocauli are decocted with water to twice, merging filtrate, half amount of getting is taken before sleeping night.If previously anaphylaxis is serious, take night and morning.
Effective combination of said medicine, coordinates mutually, can effectively reach the object of prevention pollen hypersensitivity, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 object.
1.1.1 inclusive criteria: selected 62 examples previously have the patient of pollen hypersensitivity medical history, and it is continuous more than 2 years to fall ill.The equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.Male's 40 examples wherein, women's 22 examples, age span 16 ~ 52 years old, 28.31 ± 15.32 years old mean age.
1.2 method.
1.2.1 research method: be divided into treatment group and matched group by randomly assigne, treatment group 30 examples, matched group 32 examples.Treatment time starts to start from pollen period the last week, matched group is advised and is avoided contacting pollen, is specially and occupy indoor as far as possible, closes the doors and windows to reduce entering of outdoor pollen, go out by being branded as, mask and wear the medicated clothing of long sleeves, avoid directly contacting with pollen as far as possible; Treatment group adds by Chinese medicine embodiment 3 gained Chinese medicine decoction of the present invention on matched group basis prevents, and before sleeping every day, once takes.
1.2.2 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after medication.
1.2.3 statistical analysis: carry out statistical analysis with SPSS 13.0, P< 0.05 indicates significant.
2 results.
There is situation comparison in 2.1 allergic symptoms: in matched group 32 examples, has 90.63%(29 example) there is the symptom of pollen hypersensitivity, 84.38%(27 example) must be by using antihistamine drug treat.In treatment group 30 examples, have 30%(9 example) there is the symptom of pollen hypersensitivity, 26.67%(8 example) must be by using antihistamine drug treat.Between two groups of groups, relatively, difference has extremely significantly statistical significance (P<0.01).
2.2 untoward reaction: treatment group patient's vital sign (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram and routine urinalysis Non Apparent Abnormality during medication.
3. conclusion.
The prompting of this result of study, the present invention prevents pollen hypersensitivity to have good effect and the higher feature of safety, clinic application, popularization.
Claims (2)
1. a medicine that prevents pollen hypersensitivity, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of funnel lettuce tongues, 8 ~ 15 parts of Herba Fimbristylis dichotomae, 8 ~ 15 parts of Aralia mandshuricas, 6 ~ 10 parts of Retinervus Luffae Fructuss, fragrant 6 ~ 10 parts of Zhan's sugar, 8 ~ 15 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 6 ~ 10 parts of Flos Loniceraes, 8 ~ 15 parts of Flos Eriocaulis, 3 ~ 6 parts of Gryllotalpas.
2. a kind of medicine that prevents pollen hypersensitivity according to claim 1, is characterized in that its weight proportion is: 8 parts of funnel lettuce tongues, 10 parts of Herba Fimbristylis dichotomae, 10 parts of Aralia mandshuricas, 8 parts of Retinervus Luffae Fructuss, fragrant 8 parts of Zhan's sugar, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 8 parts of Flos Loniceraes, 10 parts of Flos Eriocaulis, 5 parts of Gryllotalpas.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671404A (en) * | 2002-04-22 | 2005-09-21 | 松浦药业株式会社 | Compositions for preventing or treating pollenosis, allergic nephritis, atopic dermatitits, asthma or urticaria |
| CN1846746A (en) * | 2005-04-04 | 2006-10-18 | 吴修平 | Chinese medicine ginseng-notopterygium powder for treating rhinitis |
| CN101015599A (en) * | 2007-02-16 | 2007-08-15 | 易树林 | Composite Chinese medicine for treating pollen hypersensitivity symptom |
| CN102166282A (en) * | 2011-04-14 | 2011-08-31 | 时源 | Anti-allergic or desensitized pharmaceutical composition |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671404A (en) * | 2002-04-22 | 2005-09-21 | 松浦药业株式会社 | Compositions for preventing or treating pollenosis, allergic nephritis, atopic dermatitits, asthma or urticaria |
| CN1846746A (en) * | 2005-04-04 | 2006-10-18 | 吴修平 | Chinese medicine ginseng-notopterygium powder for treating rhinitis |
| CN101015599A (en) * | 2007-02-16 | 2007-08-15 | 易树林 | Composite Chinese medicine for treating pollen hypersensitivity symptom |
| CN102166282A (en) * | 2011-04-14 | 2011-08-31 | 时源 | Anti-allergic or desensitized pharmaceutical composition |
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| 李浩博，高卫萍.中医药治疗免疫性结膜炎概况.《湖南中医杂志》.2012,第28卷(第4期),179-180. * |
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