CN103054987B - Application of traditional Chinese medicine compound pill used for preventing locoweed poisoning of animals - Google Patents

Abstract

The invention relates to a traditional Chinese medicine compound pill used for preventing locoweed poisoning of animals. The traditional Chinese medicine compound pill is characterized by comprising the following raw materials by weight: 9 to 18 parts of dried orange peel, 9 to 18 parts of largetrifoliolious bugbane rhizome, 15 to 30 parts of honey-fried licorice root, 9 to 18 parts of tangshen, 9 to 18 parts of Chinese angelica, 9 to 18 parts of Chinese thorowax root, 30 to 60 parts of processed milkvetch root, 9 to 18 parts of bighead atractylodes rhizome and 5 to 10 parts of a trace element mixture. The traditional Chinese medicine compound pill provided by the invention is targeted at prevention of locoweed poisoning, has good security and enables breeding cost to be saved.

Description

The application of compositions in the poisoning compound traditional Chinese medicine of preparation prevention animal loco weed

Technical field

The present invention relates to the compound preparation that prevents animal loco weed poisoning, particularly a kind of poisoning compound traditional Chinese medicine of animal loco weed that prevents.

Background technology

" loco weed " (Locoweed) be Genus Oxytropis Dc ( oxytropisdC.) and Astragalus ( astragalusl .) in poisonous plants's general designation, be the most serious class poisonous weeds of harm pasture animal husbandry in world wide, that has found at present has a kind more than 2000.China loco weed is mainly distributed in the western pastoral areas such as Qinghai, Tibet, Gansu, Ningxia, the Inner Mongol, Shaanxi and Xinjiang.

The local domestic animal loco weed that generally can initiatively not search for food, only has in the winter-spring season of the barren degeneration in grassland, grass scarcity, situation that domestic animal feels unbearably hungry and just can search for food.After domestic animal searches for food loco weed, there is take chronic dysneuria as main toxonosis, cause fertility performance decline, breeding difficulty even dead, thereby the growth promoter of harm animal and poultry are planted improvement.Loco weed is because distribution is extensive, interspecies competition is with the obvious advantage, seed germination ability is stronger, turn green season early, after blooming, toxic component content is higher, palatability is better, nearly all animal susceptible, and the factor such as feed intake addiction, to livestock culturing, cause serious harm, in addition, also usually cause female animal miscarriage, infertile, fetal anomaly and male animal are sterile, affect kind of the improvement of animal reproduction and poultry, and then the development of herding industry is formed to huge threat, at present because the preventive effect of loco weed poisoning prevention agent is not ideal, and cost is high, cause the large-scale production of on going result and apply the restriction being subject to a certain extent, so development is efficient, cost is low, the detoxicating preparation of applicable extensive use or vaccine are by imperative.

The main means of processing loco weed have at present: the patent No. is the 200510119714.5 ensiling forage grass raw materials that disclose a kind of loco weed antidote and contained this antidote.Its component and mol ratio are: ferrous pharmaceutical salts 0.66-0.79, the pharmaceutical salts 1.06-1.18 of zinc are, the pharmaceutical salts 0.56-0.69 of copper, and the ensiling that contains this antidote forage grass raw material, its component and parts by weight are: antidote 0.8-1.2, loco weed 800-1200, grass 1200-2700, loco weed or edible antidote can be not poisoning in edible loco weed searches for food in certain hour after livestock edible antidote, the forage grass raw material adding after antidote is carried out to ensiling, can remove the toxicity of loco weed.

The subject matter of its existence is:

1. raw material components proportioning poor stability: the disclosed loco weed antidote of this patent, the mol ratio of its ferrous salt, zinc salt, mantoquita has very large toxicity in theory.

2. cost is higher.According to its component can rough and careless calculating its make production cost, increased herdsman's aquaculture cost, be unfavorable for extensive use.

3. the prevention time is shorter.According to the investigation of herdsman's service condition, its preventive effect time only reached about 40 days, and annual administration can not make animal spend the weeds phase, enters the rich phase of safe herbage.

Summary of the invention

The invention provides a kind ofly for preventing poisoning Chinese medicine compound pill of animal loco weed and preparation method thereof, after this Chinese medicine formula pill of livestock edible, eat loco weed by mistake within a certain period of time and can not cause poisoning.

The technical solution used in the present invention is:

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, it is characterized in that: the raw material by following portions by weight forms:

Pericarpium Citri Reticulatae 9-18 part, Rhizoma Cimicifugae 9-18 part, Radix Glycyrrhizae Preparata 15-30 part, Radix Codonopsis 9-18 part, Radix Angelicae Sinensis 9-18 part, Radix Bupleuri 9-18 part, Radix Astragali Preparata 30-60 part, Rhizoma Atractylodis Macrocephalae 9-18 part, trace element intermixture 5-10 part.

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, it is characterized in that: the raw material by following portions by weight forms:

Pericarpium Citri Reticulatae 10-15 part, Rhizoma Cimicifugae 10-15 part, Radix Glycyrrhizae Preparata 18-22 part, Radix Codonopsis 10-15 part, Radix Angelicae Sinensis 10-15 part, Radix Bupleuri 10-15 part, Radix Astragali Preparata 40-50 part, Rhizoma Atractylodis Macrocephalae 10-15 part, trace element intermixture 7-9 part.

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, it is characterized in that: the raw material by following portions by weight forms:

12 parts of Pericarpium Citri Reticulataes, 13 parts of Rhizoma Cimicifugaes, 20 parts of Radix Glycyrrhizae Preparatas, 12 parts of Radix Codonopsis, 13 parts of Radix Angelicae Sinensis, 14 parts of Radix Bupleuri, 45 parts of Radix Astragali Preparatas, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of trace element intermixtures.

Prevent a preparation method for the poisoning compound traditional Chinese medicine of animal loco weed, it is characterized in that comprising being prepared as follows step:

1. get the raw materials ready: Pericarpium Citri Reticulatae 9-18 part, Rhizoma Cimicifugae 9-18 part, Radix Glycyrrhizae Preparata 15-30 part, Radix Codonopsis 9-18 part, Radix Angelicae Sinensis 9-18 part, Radix Bupleuri 9-18 part, Radix Astragali Preparata 30-60 part, Rhizoma Atractylodis Macrocephalae 9-18 part, pulverizes, and crosses 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add hydroxypropyl cellulose binding agent;

4. in the ratio of 5-10 part, add trace element intermixture to mix;

5., after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill.

Prevent a preparation method for the poisoning compound traditional Chinese medicine of animal loco weed, it is characterized in that comprising being prepared as follows step:

1. get the raw materials ready: Pericarpium Citri Reticulatae 10-15 part, Rhizoma Cimicifugae 10-15 part, Radix Glycyrrhizae Preparata 18-22 part, Radix Codonopsis 10-15 part, Radix Angelicae Sinensis 10-15 part, Radix Bupleuri 10-15 part, Radix Astragali Preparata 40-50 part, Rhizoma Atractylodis Macrocephalae 10-15 part, pulverizes, and crosses 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add hydroxypropyl cellulose binding agent;

4. in the ratio of 7-9 part, add trace element intermixture to mix;

5., after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill.

Prevent a preparation method for the poisoning compound traditional Chinese medicine of animal loco weed, it is characterized in that comprising being prepared as follows step:

1. get the raw materials ready: 12 parts of Pericarpium Citri Reticulataes, 13 parts of Rhizoma Cimicifugaes, 20 parts of Radix Glycyrrhizae Preparatas, 12 parts of Radix Codonopsis, 13 parts of Radix Angelicae Sinensis, 14 parts of Radix Bupleuri, 45 parts of Radix Astragali Preparatas, 12 parts of the Rhizoma Atractylodis Macrocephalaes, pulverize, and cross 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add hydroxypropyl cellulose binding agent;

4. in the ratio of 8 parts, add trace element intermixture to mix;

5., after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill.

The present invention has the following advantages:

1, the present invention compares compound preparation for preventing animal loco weed poisoning, its efficacy effect is preventing poisoning, poisoning removing toxic substances, its mechanism of action is the induction anabolic effect promoting the enzymatic synthesis of α-mannoside, improve the content of α-mannosidase in body, increased the activity of lysosome α-mannosidase, fully decompose because the poisoning mannose causing is piled up, guarantee the homergy of the smooth synthetic and body of glycoprotein, in formula, increase in addition trace element intermixture, strengthened the immunity of animal body.

2, to take prevention be object in the present invention, is that animal is taken medicine before not poisoning, generally, according to lamb 1 ball (11 grams, every ball) first, after 3.5 months, adds 1 ball; Adult sheep gavages 2 balls first, adds 1 ball after 3.5 months; Cattle takes 3 balls first, adds 2 balls after 3.5 months, even if animal has been eaten loco weed by mistake, also can not cause poisoningly, even occurs dead.

3, safety of the present invention is good.Prevention animal loco weed poisoning Chinese medicine compound pill definite ingredients, proves through safety toxicological experiment, without teratogenesis, mutagenesis, the toxic and side effects such as carcinogenic, safe and reliable in production.

4, save aquaculture cost.The poisoning Chinese medicine compound pill of prevention animal loco weed of the present invention, its medicinal raw material market is easily purchased, and price is relatively cheap, greatly reduces drug cost, 1 yuan of the about RMB of every ball cost.

5, the present invention has extended the preventing poisoning time.In actual production, by various dose administration, simple to operate for the animal of all ages and classes, extended the preventing poisoning time can reach more than 50 days.

6, the present invention supplements the necessary trace element of domestic animal, has strengthened the alimentation of domestic animal, therefore promotes domestic animal growth promoter.

The specific embodiment

Embodiment 1

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, by the raw material of following portions by weight, formed:

Pericarpium Citri Reticulatae 9-18 part, Rhizoma Cimicifugae 9-18 part, Radix Glycyrrhizae Preparata 15-30 part, Radix Codonopsis 9-18 part, Radix Angelicae Sinensis 9-18 part, Radix Bupleuri 9-18 part, Radix Astragali Preparata 30-60 part, Rhizoma Atractylodis Macrocephalae 9-18 part, trace element intermixture 5-10 part.

Preparation method for preventing the poisoning compound traditional Chinese medicine of animal loco weed, comprises and is prepared as follows step:

1. get the raw materials ready: Pericarpium Citri Reticulatae 9-18 part, Rhizoma Cimicifugae 9-18 part, Radix Glycyrrhizae Preparata 15-30 part, Radix Codonopsis 9-18 part, Radix Angelicae Sinensis 9-18 part, Radix Bupleuri 9-18 part, Radix Astragali Preparata 30-60 part, Rhizoma Atractylodis Macrocephalae 9-18 part, pulverizes, and crosses 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add hydroxypropyl cellulose binding agent;

4. in the ratio of 5-10 part, add trace element intermixture to mix; Described trace element intermixture is by following raw material: ferrous sulfate, copper lysine, zinc methionine, manganese sulfate, sodium selenite, potassium iodate, cobaltous chloride mix, this trace element intermixture is directly bought animal and is added trace element intermixture used on market, comprise ferrum, copper, zinc, manganese, selenium, iodine, cobalt trace element, in prevention antidote of the present invention, help out, be mainly to supplement some essential elements that animal is lacked in growth course, also can add antioxidant;

5. after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill, described pill is every 10-12 gram.

Its usage is: animal is not taken medicine before poisoning, generally, according to lamb 1 ball (11 grams, every ball) first, after 3.5 months, adds 1 ball; Adult sheep gavages 2 balls first, adds 1 ball after 3.5 months; Cattle takes 3 balls first, adds 2 balls after 3.5 months.Domestic animal is after taking this pill, even if animal has been eaten loco weed by mistake, also can not cause poisoningly, even occurs dead.

Its mechanism of action is the induction anabolic effect promoting the enzymatic synthesis of α-mannoside, improve the content of α-mannosidase in body, increased the activity of lysosome α-mannosidase, fully decompose because the poisoning mannose causing is piled up, guarantee the homergy of the smooth synthetic and body of glycoprotein, in formula, increase in addition trace element intermixture, strengthened the immunity of animal body.

Embodiment 2

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, by the raw material of following portions by weight, formed:

Pericarpium Citri Reticulatae 10-15 part, Rhizoma Cimicifugae 10-15 part, Radix Glycyrrhizae Preparata 18-22 part, Radix Codonopsis 10-15 part, Radix Angelicae Sinensis 10-15 part, Radix Bupleuri 10-15 part, Radix Astragali Preparata 40-50 part, Rhizoma Atractylodis Macrocephalae 10-15 part, trace element intermixture 7-9 part;

Preparation method for preventing the poisoning compound traditional Chinese medicine of animal loco weed, comprises and is prepared as follows step:

1. get the raw materials ready: Pericarpium Citri Reticulatae 10-15 part, Rhizoma Cimicifugae 10-15 part, Radix Glycyrrhizae Preparata 18-22 part, Radix Codonopsis 10-15 part, Radix Angelicae Sinensis 10-15 part, Radix Bupleuri 10-15 part, Radix Astragali Preparata 40-50 part, Rhizoma Atractylodis Macrocephalae 10-15 part, pulverizes, and crosses 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add hydroxypropyl cellulose binding agent;

4. in the ratio of 7-9 part, add trace element intermixture to mix;

5. after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill, described pill is every 10-12 gram.

Embodiment 3

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, by the raw material of following portions by weight, formed:

9 grams of Pericarpium Citri Reticulataes, 9 grams of Rhizoma Cimicifugaes, 15 grams of Radix Glycyrrhizae Preparatas, 9 grams of Radix Codonopsis, 9 grams of Radix Angelicae Sinensis, 9 grams of Radix Bupleuri, 30 grams of Radix Astragali Preparatas, 9 grams of the Rhizoma Atractylodis Macrocephalaes, 5 grams of trace element intermixtures;

Preparation method for preventing the poisoning compound traditional Chinese medicine of animal loco weed, comprises and is prepared as follows step:

1. get the raw materials ready: 9 grams of Pericarpium Citri Reticulataes, 9 grams of Rhizoma Cimicifugaes, 15 grams of Radix Glycyrrhizae Preparatas, 9 grams of Radix Codonopsis, 9 grams of Radix Angelicae Sinensis, 9 grams of Radix Bupleuri, 30 grams of Radix Astragali Preparatas, 9 grams of the Rhizoma Atractylodis Macrocephalaes, pulverize, and cross 40 mesh sieves;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add 9.9 grams of hydroxypropyl cellulose binding agents;

4. in the ratio of 5 grams, add trace element intermixture to mix

5. after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill, described pill is 11 grams every.

Embodiment 4

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, by the raw material of following portions by weight, formed:

18 grams of Pericarpium Citri Reticulataes, 18 grams of Rhizoma Cimicifugaes, 30 grams of Radix Glycyrrhizae Preparatas, 18 grams of Radix Codonopsis, 18 grams of Radix Angelicae Sinensis, 18 grams of Radix Bupleuri, 60 grams of Radix Astragali Preparatas, 18 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams of trace element intermixtures;

Preparation method for preventing the poisoning compound traditional Chinese medicine of animal loco weed, comprises and is prepared as follows step:

1. get the raw materials ready: 18 grams of Pericarpium Citri Reticulataes, 18 grams of Rhizoma Cimicifugaes, 30 grams of Radix Glycyrrhizae Preparatas, 18 grams of Radix Codonopsis, 18 grams of Radix Angelicae Sinensis, 18 grams of Radix Bupleuri, 60 grams of Radix Astragali Preparatas, 18 grams of the Rhizoma Atractylodis Macrocephalaes, pulverize, and cross 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add 19.8 grams of hydroxypropyl cellulose binding agents;

4. in the ratio of 10 grams, add trace element intermixture to mix; Described trace element intermixture is comprised of following raw material: ferrous sulfate, copper lysine, zinc methionine, manganese sulfate, sodium selenite, potassium iodate, cobaltous chloride;

5. after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill, described pill is 11 grams every.

Embodiment 5

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, by the raw material of following portions by weight, formed:

30 grams of Radix Codonopsis, 30 grams of Radix Angelicae Sinensis, 30 grams of Rhizoma Cimicifugaes, 30 grams of Radix Bupleuri, 30 grams of Pericarpium Citri Reticulataes, 100 grams of Radix Astragali Preparatas, 50 grams of Radix Glycyrrhizae Preparatas, 30 grams of the Rhizoma Atractylodis Macrocephalaes, 8 grams of trace element intermixtures;

Preparation method for preventing the poisoning compound traditional Chinese medicine of animal loco weed, comprises and is prepared as follows step:

1. get the raw materials ready: 30 grams of Radix Codonopsis, 30 grams of Radix Angelicae Sinensis, 30 grams of Rhizoma Cimicifugaes, 30 grams of Radix Bupleuri, 30 grams of Pericarpium Citri Reticulataes, 100 grams of Radix Astragali Preparatas, 50 grams of Radix Glycyrrhizae Preparatas, 30 grams of the Rhizoma Atractylodis Macrocephalaes, pulverize, and cross 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add 33.3 grams of hydroxypropyl cellulose binding agents;

4. in the ratio of 16 grams, add trace element intermixture to mix;

5. after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill, described pill is 11 grams every.

Embodiment 6

For preventing the poisoning compound traditional Chinese medicine of animal loco weed, by the raw material of following portions by weight, formed:

12 grams of Pericarpium Citri Reticulataes, 13 grams of Rhizoma Cimicifugaes, 20 grams of Radix Glycyrrhizae Preparatas, 12 grams of Radix Codonopsis, 13 grams of Radix Angelicae Sinensis, 14 grams of Radix Bupleuri, 45 grams of Radix Astragali Preparatas, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 8 grams of trace element intermixtures;

Preparation method for preventing the poisoning compound traditional Chinese medicine of animal loco weed, comprises and is prepared as follows step:

1. get the raw materials ready: 12 grams of Pericarpium Citri Reticulataes, 13 grams of Rhizoma Cimicifugaes, 20 grams of Radix Glycyrrhizae Preparatas, 12 grams of Radix Codonopsis, 13 grams of Radix Angelicae Sinensis, 14 grams of Radix Bupleuri, 45 grams of Radix Astragali Preparatas, 12 grams of the Rhizoma Atractylodis Macrocephalaes, cross 40-80 mesh sieve;

2. the Chinese medicinal powder after sieving is mixed;

3. in the ratio of compound preparation 10%, add 33.3 grams of hydroxypropyl cellulose binding agents;

4. in the ratio of 8 grams, add trace element intermixture to mix; Described trace element intermixture is comprised of following raw material:

5. after the mixture of various compositions fully mixes, under the pressure of 25t, be pressed into pill, described pill is 11 grams every.

pharmacology analysis is as follows:

1. the poisoning diagnostic criteria of livestock locoweed

According to the medical history that has the loco weed that searches for food, clinical symptoms, serum alkaline phosphatase, blood urea nitrogen, glutamic oxaloacetic transaminase, GOT, the significant change of alpha-Mannosidase content, in conjunction with Histopathologic characteristics such as each internal organs of domestic animal, neurocyte vacuolations, can make and making a definite diagnosis.

1. there is the medical history of herding the loco weed that searches for food: in neopathy area, also need plant to do the evaluation of planting, as for novel species can carry out thin layer chromatography inspection by herborization sample, see whether contain (.+-.)-Swainsonine.Concrete grammar is to get plant sample, adopts alkaloid extraction method to propose total alkaloids.Total alkaloids is through thin layer chromatography inspection, chloroform: methanol: ammonia: water (70:26:2:2) developing solvent launches, Ehrlic ' s reagent colour development, if occur, aubergine speckle is positive reaction.

2. there is the poisoning distinctive clinical symptoms of loco weed, as lifting ear stress sensitive, posterior paralysis, walking is waved, and head is level and trembles etc.

3. lab testing, alpha-Mannosidase activity decreased, urine oligosaccharide content increases, and the sweet polysaccharide in urine oligosaccharide also obviously raises.

2. prevent the poisoning Chinese medicine compound pill using method of animal loco weed:

Prevention animal loco weed poisoning Chinese medicine compound pill, is that animal is taken medicine before not poisoning, generally, according to lamb 1 ball first, adds 1 ball after 3.5 months; Adult sheep gavages 2 balls first, adds 1 ball after 3.5 months; Cattle takes 3 balls first, adds 2 balls after 3.5 months.

3. the poisoning Chinese medicine compound pill effect criterion of prevention animal loco weed

Effective: after using by the poisoning Chinese medicine compound pill using method of prevention animal loco weed, the poisoning distinctive clinical symptoms of loco weed does not appear in domestic animal within a certain period of time, and it is good that the mental status is recovered, and normally searches for food, without any untoward reaction.

Invalid: after using by the poisoning Chinese medicine compound pill using method of prevention animal loco weed, the poisoning distinctive clinical symptoms of loco weed appears in domestic animal, and the mental status is low, searches for food undesired, has death to wait untoward reaction to occur.

4. the pharmacodynamics test of loco weed poisoning treatment removing toxic substances compound recipe water preparation

By 32 Tibetan, be that goat is divided into 4 groups at random, be respectively test group I, test group II, test group III and matched group (every group of male four mothers of goat four, body weight equates or is more or less the same), test group I (embodiment 3), test group II (embodiment 4), test group III (embodiment 5) is by the method administration of prevention compound recipe pill, then with feed loco weed (Astragalus strictus) hay powder 30 days of amount of 10g/kgBW every day, observe clinical symptoms every day, if occur, loco weed poisoning symptom stops the loco weed hay powder of feeding, not administration of matched group, but also with loco weed, feed.Before test and every 7 days of duration of test blood sampling 1 time, do hemoglobin and serum enzyme, Biochemical Indices In Serum check.Through two places, four repeated trials results show: poisoning symptom does not appear in test group goat, and also without the phenomena of mortality, slight inappetence appears in test group III.There is poisoning symptom in matched group goat, continues for a long time the loco weed of feeding, and there will be the phenomena of mortality.According to the hemoglobin inspection that gathers each test group and matched group, find that test group I content of hemoglobin reduces; Serum analysis ɑ-mannosidase, alkali phosphatase, glutamic oxaloacetic transaminase, GOT and blood urea nitrogen determination of activity result show, test group I, test group II and test group III and matched group comparison, significant difference (P ﹥ 0.05).

the poisoning Chinese medicine compound pill field test results of prevention animal loco weed

Experimental field	Domestic animal classification	Quantity	Successful	DeGrain	Significant effective rate
						Dangxiong County, Lhasa	Goat	32×2	58	6	90.6%
Nimu County, Lhasa	Goat	32×2	57	7	89.0%

Claims (6)

1. an application of a composition in the preparation of a compound Chinese medicine for preventing animal locopoisoning, characterized in that: said composition is made up of the following raw materials in parts by weight: 9-18 parts of tangerine peel, 9-18 parts of cohosh, 15-30 parts of roasted licorice, 9-18 parts of codonopsis, 9-18 parts of angelica, 9-18 parts of Bupleurum, 30-60 parts of roasted astragalus, 9-18 parts of Atractylodes macrocephala parts, 5-10 parts of trace element mixture; The trace element mixture plays an auxiliary role and is formed by mixing ferrous sulfate, copper lysine, zinc methionine, manganese sulfate, sodium selenite, potassium iodate and cobalt chloride. 2. the application of composition according to claim 1 in the preparation of the Chinese medicine compound preparation preventing animal locoweed poisoning, is characterized in that: composition is made up of the raw material of following parts by weight: 10-15 parts of tangerine peel, 10-15 parts of cohosh, 18-22 parts of roasted licorice, 10-15 parts of codonopsis, 10-15 parts of angelica, 10-15 parts of Bupleurum, 40-50 parts of roasted astragalus, 10-15 parts of Atractylodes macrocephala parts, 7-9 parts of trace element mixture. 3. the application of composition according to claim 2 in the preparation of the Chinese medicine compound preparation preventing animal locoweed poisoning, is characterized in that: composition is made up of the raw material of following parts by weight: 12 parts of tangerine peel, 13 parts of Cimicifuga, 20 parts of Zhigancao, 12 parts of Codonopsis, 13 parts of Angelica, 14 parts of Bupleurum, 45 parts of Radix Astragali, 12 parts of Atractylodes macrocephala, and 8 parts of trace element mixture. 4. the application of the composition according to claim 1 in the preparation of the compound Chinese medicine for preventing animal locoweed poisoning, is characterized in that comprising the following preparation steps: ①Material preparation: 9-18 parts of tangerine peel, 9-18 parts of cohosh, 15-30 parts of roasted licorice, 9-18 parts of codonopsis, 9-18 parts of angelica, 9-18 parts of Bupleurum, 30-60 parts of roasted astragalus, Atractylodes macrocephala 9-18 parts, pulverized, passed through a 40-80 mesh sieve; ②Mix the sieved Chinese medicine powder; ③According to the ratio of 10% of compound preparation, add hydroxypropyl cellulose binder; ④ Add trace element mixture in proportion of 5-10 parts and mix well; ⑤ After the mixture of various ingredients is fully mixed, it is pressed into pills under a pressure of 25t. 5. the application of composition according to claim 4 in the preparation of the Chinese medicine compound preparation preventing animal locoweed poisoning, is characterized in that comprising following preparation steps: ①Material preparation: 10-15 parts of tangerine peel, 10-15 parts of cohosh, 18-22 parts of roasted licorice, 10-15 parts of codonopsis, 10-15 parts of angelica, 10-15 parts of Bupleurum, 40-50 parts of roasted astragalus, Atractylodes macrocephala 10-15 parts, pulverized, passed through a 40-80 mesh sieve; ②Mix the sieved Chinese medicine powder; ③According to the ratio of 10% of compound preparation, add hydroxypropyl cellulose binder; ④ Add trace element mixture in proportion of 7-9 parts and mix well; ⑤ After the mixture of various ingredients is fully mixed, it is pressed into pills under a pressure of 25t. 6. the application of the composition according to claim 4 in the preparation of the compound Chinese medicine for preventing animal locoweed poisoning, is characterized in that comprising the following preparation steps: ①Material preparation: 12 parts of tangerine peel, 13 parts of cohosh, 20 parts of roasted licorice, 12 parts of codonopsis, 13 parts of angelica, 14 parts of Bupleurum, 45 parts of roasted astragalus, 12 parts of Atractylodes macrocephala, crushed, and passed through a 40-80 mesh sieve; ②Mix the sieved Chinese medicine powder; ③According to the ratio of 10% of compound preparation, add hydroxypropyl cellulose binder; ④ Add the trace element mixture in the proportion of 8 parts and mix well; ⑤ After the mixture of various ingredients is fully mixed, it is pressed into pills under a pressure of 25t.