CN103301260B - External use medicine for treating arthritic and preparation method thereof - Google Patents
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Abstract
本发明公开了一种治疗关节炎的外用药物,其特征在于:它是由下述重量的中药原料配制而成的,鲜地骨皮100克、鲜蒲公英100克、鲜鹅不食草100克、鲜三加皮的叶100克、鲜冬瓜皮100克、鲜薄荷80克、鲜艾叶80克、鲜浮萍80克。本发明的药物的优点:治疗关节炎有效率90%,治愈率80%。The invention discloses a medicine for external use for treating arthritis, which is characterized in that it is prepared from the following traditional Chinese medicine raw materials: 100 grams of fresh Digupi, 100 grams of fresh dandelion, and 100 grams of fresh goose not eating grass 100 grams of fresh Sanjiapi leaves, 100 grams of fresh wax gourd skin, 80 grams of fresh mint, 80 grams of fresh mugwort leaves, and 80 grams of fresh duckweed. The medicine of the present invention has the advantages that the effective rate of treating arthritis is 90%, and the cure rate is 80%.
Description
技术领域 technical field
本发明属于纯中药技术领域,具体地说是一种治疗关节炎的外用药物及其制备方法。 The invention belongs to the technical field of pure traditional Chinese medicines, in particular to an external medicine for treating arthritis and a preparation method thereof. the
背景技术 Background technique
关节炎,临床主要症状为关节红、肿、热、痛、关节变形、肿大、屈伸不利,关节周围组织水肿、麻木疼痛,功能障碍。现代医学认为,关节炎的病因,主要与炎症、自身免疫反应、感染、代谢紊乱、创伤、退行性病变等因素有关。中医认为关节炎属于中医的‘骨痹’的范畴。骨痹是由人体正气不足或肝肾两虚,筋骨失于濡养,受到风、寒、湿等外邪侵入经络,致使经络闭塞,阻滞关节,气滞血凝,日久致使关节变形、肿大、屈伸不利,麻木疼痛。关节炎的治疗,西医主要以止疼药物为主或打封闭针,关节腔穿刺抽液或腔内注射糖皮质激素、甲氨蝶呤及透明质酸。或内服消炎痛,布洛芬等药物,对胃刺激大,副作用大,长期使用患者接受不了,打封闭针主要用盐酸普鲁卡因、强的松龙,治疗虽然有效,但是效果不理想,有的则采取手术,更有甚者造成截瘫,更让患者不能接受。中医主要用药物和推拿按摩,针灸,拔罐等疗法,现有的中药疗效都不太理想,比如,“万通筋骨贴”《通化万通药业股份有限公司》治疗效果不理想。 Arthritis, the main clinical symptoms are joint redness, swelling, heat, pain, joint deformation, swelling, poor flexion and extension, tissue edema around the joint, numbness and pain, and dysfunction. Modern medicine believes that the etiology of arthritis is mainly related to factors such as inflammation, autoimmune reaction, infection, metabolic disorder, trauma, and degenerative disease. Chinese medicine believes that arthritis belongs to the category of "gubi" in traditional Chinese medicine. Gubi is caused by the lack of righteousness of the human body or the deficiency of liver and kidney, the muscles and bones are lost in nourishment, and the external evils such as wind, cold, and damp invade the meridians, resulting in the blockage of the meridians, blockage of joints, stagnation of qi and blood coagulation, and joint deformation over time. Swelling, poor flexion and extension, numbness and pain. For the treatment of arthritis, Western medicine mainly focuses on analgesic drugs or sealing needles, joint cavity puncture to extract fluid or intracavitary injection of glucocorticoids, methotrexate and hyaluronic acid. Orally take indomethacin, ibuprofen and other medicines, which are very irritating to the stomach and have great side effects, which cannot be accepted by patients after long-term use. Procaine hydrochloride and prednisolone are mainly used for sealing injections. Although the treatment is effective, the effect is not ideal. Others take surgery, and some even cause paraplegia, which is unacceptable to patients. Traditional Chinese medicine mainly uses medicine, massage, acupuncture, cupping and other therapies. The curative effect of existing traditional Chinese medicine is not satisfactory. the
发明内容 Contents of the invention
本发明的目的就是提供一种专门治疗关节红、肿、热、痛、关节变形、肿大、屈伸不利,关节周围组织水肿、麻木疼痛,具有疗效确切,使用方 便,无任何副作用,效果显著,治愈率高的治疗关节炎的外用药物及其制备方法。 The purpose of the present invention is to provide a special treatment for joint redness, swelling, heat, pain, joint deformation, swelling, unfavorable flexion and extension, tissue edema around the joint, numbness and pain, with definite curative effect, convenient use, no side effects, and remarkable effect , an externally used medicine for treating arthritis with a high cure rate and a preparation method thereof. the
本发明的技术方案是这样实现的,一种治疗关节炎的外用药物,其特征在于:它是由下述重量的中药原料配制而成的,鲜地骨皮100克、鲜蒲公英100克、鲜鹅不食草100克、鲜三加皮的叶100克、鲜冬瓜皮100克、鲜薄荷80克、鲜艾叶80克、鲜浮萍80克。 The technical solution of the present invention is realized in this way, a kind of external medicine for treating arthritis, it is characterized in that: it is formulated by the following Chinese medicine raw materials of weight, fresh Digupi 100 grams, fresh dandelion 100 grams, fresh Goose does not eat grass 100 grams, 100 grams of fresh sanjia skin leaves, 100 grams of fresh wax gourd skin, 80 grams of fresh mint, 80 grams of fresh mugwort leaves, and 80 grams of fresh duckweed. the
本发明的药物制备方法:将鲜地骨皮100克、鲜蒲公英100克、鲜鹅不食草100克、鲜三加皮的叶100克、鲜冬瓜皮100克、鲜薄荷80克、鲜艾叶80克、鲜浮萍80克一起放进石臼内,用鲜桑木棍锤打,一直锤打到如泥出汁为止。 The preparation method of the medicine of the present invention: 100 grams of fresh ground bone skin, 100 grams of fresh dandelion, 100 grams of fresh goose non-grass, 100 grams of leaves of fresh sanjia skin, 100 grams of fresh wax gourd skin, 80 grams of fresh mint, and fresh mugwort leaves Put 80 grams of fresh duckweed and 80 grams of fresh duckweed into the stone mortar together, and hammer with fresh mulberry sticks until the juice is like mud. the
本发明药物的使用方法:根据关节部位取适量锤打好的药物分别敷在肿大关节部位,然后用无毒塑料布裹好,再用医用胶布粘好,24小时换一次药。 The method of using the medicine of the present invention: take appropriate amount of hammered medicine according to the joint position and apply it on the swollen joint respectively, then wrap it with non-toxic plastic cloth, stick it with medical adhesive tape, and change the medicine every 24 hours. the
治疗疗程:5天为一个疗程,轻者1-2个疗程可治愈,重者3-5个疗程可治愈。 Treatment course: 5 days as a course of treatment, mild cases can be cured in 1-2 courses of treatment, severe cases can be cured in 3-5 courses of treatment. the
主治:因关节炎引起的关节红、肿、热、痛、关节变形、肿大、屈伸不利,关节周围组织水肿、麻木疼痛,筋脉拘挛,关节活动不利。 Indications: Joint redness, swelling, heat, pain, joint deformation, swelling, poor flexion and extension caused by arthritis, edema, numbness and pain in the tissues around the joint, spasm of tendons, and poor joint movement. the
治疗效果:有效率90%,治愈率80%。 Treatment effect: the effective rate is 90%, and the cure rate is 80%. the
本发明药物具有利水消肿,消炎止痛,消痈散结的功效。 The medicine of the present invention has the effects of promoting diuresis for reducing swelling, reducing inflammation and relieving pain, and eliminating carbuncle and dissipating stagnation. the
说明:本发明的药物用干药无效,用单样鲜药无效,用其中的2样或几样鲜药用鲜桑木棍锤打,一直锤打到出汁,敷在肿大关节部位效果不明显。 Explanation: The medicine of the present invention is ineffective with dry medicine, and it is ineffective with single fresh medicine. Two or several fresh medicines are hammered with fresh mulberry sticks until the juice comes out, and the effect is not obvious when applied to swollen joints. . the
本发明的药物机理如下: The drug mechanism of the present invention is as follows:
鲜地骨皮:味甘,微苦,性寒。入肺、肝、肾经。具有清肺止咳,退虚热的功效。参考《中医方药学,广东中医学院编,广东人民出版社1973年6月第一次印刷,见156页》 Fresh Digupi: sweet in taste, slightly bitter, cold in nature. Go into lung, liver, kidney channel. It has the effects of clearing the lung and relieving cough, and reducing asthenic fever. Refer to "Prescription and Pharmacy of Traditional Chinese Medicine, edited by Guangdong College of Traditional Chinese Medicine, first printed by Guangdong People's Publishing House in June 1973, see page 156"
鲜蒲公英:味苦、甘,性寒。入肺、胃经。具有清热解毒,消痈散结的功效。(同上,见166页) Fresh dandelion: bitter, sweet, cold in nature. Enter lung, stomach warp. There is heat-clearing and toxic substances removing, the effect of eliminating carbuncle and dissipating stagnation. (same as above, see page 166)
鲜鹅不食草:味辛,性平。具有祛痰止咳,通鼻窍,退翳膜,截疟,祛风散瘀止痛的功效。(同上,见415-416) Fresh geese do not eat grass: spicy and mild in nature. It has the effects of eliminating phlegm and relieving cough, clearing nasal orifices, withdrawing nebula membrane, cutting off malaria, expelling wind, dissipating blood stasis and relieving pain. (Ibid, see 415-416)
鲜三加皮的叶:味苦,性微寒。具有清热解毒的功效。(同上,见376页) Fresh Sanjiapi leaves: bitter in taste, slightly cold in nature. It has the effect of clearing heat and detoxifying. (same as above, see page 376)
鲜冬瓜皮:味甘,性微寒。具有利水消肿的功效。(同上,见312页) Fresh wax gourd rind: sweet in taste, slightly cold in nature. It has the effect of diuresis and swelling. (same as above, see page 312)
鲜薄荷(全草):味辛,性凉。气清香。入肺、肝经。具有疏散风热,清头目,透疹,疏肝解郁的功效。(同上,见83页) Fresh mint (whole herb): pungent in taste, cool in nature. The air is fragrant. Go into lung, Liver Channel. It has the effects of dispelling wind-heat, clearing the head, clearing rash, soothing the liver and relieving depression. (same as above, see page 83)
鲜艾叶:味苦、辛,性温。入脾、肝、肾经。具有温经止血,调经安胎,散寒除湿的功效。(同上,见527-528页) Fresh Artemisia argyi: bitter, pungent, warm in nature. Go into spleen, liver, kidney channel. It has the effects of warming the meridians for hemostasis, regulating menstruation and preventing miscarriage, expelling cold and dehumidifying. (Ibid, see pages 527-528)
鲜浮萍:味辛,寒。入肺经。具有发汗解表,行水消肿。(同上,见95页) Fresh duckweed: pungent in taste, cold. Go into the lung meridian. It has the function of sweating, relieving the exterior surface, promoting water and reducing swelling. (same as above, see page 95)
方中用鲜地骨皮、鲜蒲公英、鲜鹅不食草、鲜三加皮的叶,鲜冬瓜皮、鲜薄荷、鲜艾叶、鲜浮萍诸药相合,相得益彰,具有利水消肿,消炎止痛,消痈散结的功效,迅速治愈关节炎。 In the prescription, fresh ground bone skin, fresh dandelion, fresh goose does not eat grass, fresh leaves of Sanjia skin, fresh wax gourd skin, fresh mint, fresh mugwort leaves, and fresh duckweed are used together to complement each other. , the effect of eliminating carbuncle and dissipating stagnation, and quickly cure arthritis. the
关节炎的病因,主要与炎症、自身免疫反应、感染、代谢紊乱、创伤、退行性病变等因素有关。中医认为关节炎属于中医的‘骨痹’的范畴。骨 痹是由人体正气不足或肝肾两虚,筋骨失于濡养,受到风、寒、湿等外邪侵入经络,致使经络闭塞,阻滞关节,气滞血凝,日久致使关节变形、肿大、屈伸不利,麻木疼痛。治宜利水消肿,消炎止痛,消痈散结方能迅速治愈关节炎。 The etiology of arthritis is mainly related to factors such as inflammation, autoimmune reaction, infection, metabolic disorder, trauma, and degenerative disease. Chinese medicine believes that arthritis belongs to the category of "gubi" in traditional Chinese medicine. Gubi is caused by the lack of righteousness of the human body or the deficiency of liver and kidney, the muscles and bones are lost in nourishment, and the external evils such as wind, cold, and damp invade the meridians, resulting in the blockage of the meridians, blockage of joints, stagnation of qi and blood coagulation, resulting in joint deformation, Swelling, poor flexion and extension, numbness and pain. It is suitable for diuresis to reduce swelling, anti-inflammatory and pain-relieving, and carbuncle and stagnation can quickly cure arthritis. the
具体实施方式 Detailed ways
实施例:取鲜地骨皮100克、鲜蒲公英100克、鲜鹅不食草100克、鲜三加皮的叶100克、鲜冬瓜皮100克、鲜薄荷80克、鲜艾叶80克、鲜浮萍80克。 Embodiment: get 100 grams of fresh ground bone skin, 100 grams of fresh dandelion, 100 grams of fresh goose not eating grass, 100 grams of leaves of fresh sanjia skin, 100 grams of fresh wax gourd skin, 80 grams of fresh mint, 80 grams of fresh mugwort leaves, fresh 80 grams of duckweed. the
本发明的药物制备方法:将鲜地骨皮100克、鲜蒲公英100克、鲜鹅不食草100克、鲜三加皮的叶100克、鲜冬瓜皮100克、鲜薄荷80克、鲜艾叶80克、鲜浮萍80克一起放进石臼内,用鲜桑木棍锤打,一直锤打到如泥出汁为止。 The preparation method of the medicine of the present invention: 100 grams of fresh ground bone skin, 100 grams of fresh dandelion, 100 grams of fresh goose non-grass, 100 grams of leaves of fresh sanjia skin, 100 grams of fresh wax gourd skin, 80 grams of fresh mint, and fresh mugwort leaves Put 80 grams of fresh duckweed and 80 grams of fresh duckweed into the stone mortar together, and hammer with fresh mulberry sticks until the juice is like mud. the
本发明药物的使用方法:根据关节部位取适量锤打好的药物分别敷在肿大关节部位,然后用无毒塑料布裹好,再用医用胶布粘好,24小时换一次药。 The method of using the medicine of the present invention: take appropriate amount of hammered medicine according to the joint position and apply it on the swollen joint respectively, then wrap it with non-toxic plastic cloth, stick it with medical adhesive tape, and change the medicine every 24 hours. the
治疗疗程:5天为一个疗程,轻者1-2个疗程可治愈,重者3-5个疗程可治愈。 Treatment course: 5 days as a course of treatment, mild cases can be cured in 1-2 courses of treatment, severe cases can be cured in 3-5 courses of treatment. the
主治:因关节炎引起的关节红、肿、热、痛、关节变形、肿大、屈伸不利,关节周围组织水肿、麻木疼痛,筋脉拘挛,关节活动不利。 Indications: Joint redness, swelling, heat, pain, joint deformation, swelling, poor flexion and extension caused by arthritis, edema, numbness and pain in the tissues around the joint, spasm of tendons, and poor joint movement. the
治疗效果:有效率90%,治愈率80%。 Treatment effect: the effective rate is 90%, and the cure rate is 80%. the
本发明药物具有利水消肿,消炎止痛,消痈散结的功效。 The medicine of the present invention has the effects of promoting diuresis for reducing swelling, reducing inflammation and relieving pain, and eliminating carbuncle and dissipating stagnation. the
为表明本发明药物的疗效,纳入病例:取200例患关节炎患者,其中:男100例,患膝关节肿大的50例,手指关节肿大的50例;女100例,患膝关节肿大的50例,手指关节肿大的50例;其临床主要症状:关节麻木疼痛,关节肿大,关节囊水肿,关节变形,屈伸不利,怕冷、怕凉水。将这200例关节炎患者平均分为对照组和实验组,对照组分给100例,其中男50例,患膝关节肿大的25例,手指关节肿大的25例;女50例,其中患膝关节肿大的25例,手指关节肿大的25例;实验组分给100例,其中男50例,患膝关节肿大的25例,手指关节肿大的25例;女50例,其中患膝关节肿大的25例,手指关节肿大的25例;立档留查加以统计对比。对照组用“万通筋骨贴”《通化万通药业股份有限公司》治疗,一日一贴,每个疗程5天,治疗2-6个疗程;实验组用本发明药物按本发明药物治疗方法治疗,治疗2-6个疗程,皆以症状:关节麻木疼痛,关节肿大,关节囊水肿,关节变形,屈伸不利,怕冷、怕凉水减轻为有效;症状:关节麻木疼痛,关节肿大,关节囊水肿,关节变形,屈伸不利,怕冷、怕凉水全部消失为痊愈,统计表明结果如下: For showing the curative effect of medicine of the present invention, include case: get 200 routine patients with arthritis, wherein: male 100 examples, suffer from knee joint swelling 50 examples, finger joint swelling 50 examples; Female 100 examples, suffer from knee joint swelling 50 cases of big ones, 50 cases of swollen finger joints; the main clinical symptoms: joint numbness and pain, joint swelling, joint capsule edema, joint deformation, poor flexion and extension, fear of cold and cold water. The 200 cases of arthritis patients were equally divided into control group and experimental group. The control group was divided into 100 cases, including 50 male cases, 25 cases with knee joint swelling, and 25 finger joint swelling cases; 50 female cases, including Suffer from 25 cases of knee joint swelling, 25 cases of finger joint swelling; 100 cases are given experimental components, including 50 males, 25 cases of knee joint swelling, 25 finger joint swelling; 50 females, Among them, 25 cases suffered from knee joint swelling, and 25 cases had finger joint swelling; they were kept on file for statistical comparison. The control group is treated with "Wantong Muscle and Bone Paste" "Tonghua Wantong Pharmaceutical Co., Ltd.", one patch a day, 5 days for each course of treatment, and 2-6 courses of treatment; the experimental group is treated with the medicine of the present invention according to the medicine of the present invention Method of treatment, 2-6 courses of treatment, all based on symptoms: joint numbness and pain, joint swelling, joint capsule edema, joint deformation, poor flexion and extension, fear of cold, fear of cold water to alleviate the symptoms; symptoms: joint numbness and pain, joint swelling , joint capsule edema, joint deformation, poor flexion and extension, and fear of cold and cold water all disappear as a cure. Statistics show that the results are as follows:
表1:对照疗效情况 Table 1: Comparison of curative effect
表2、实验组疗效情况 Table 2. The curative effect of the experimental group
试验结果表明,本发明的药物治疗关节炎的效果优于“万通筋骨贴”《通化万通药业股份有限公司》治疗关节炎的效果。 The test results show that the effect of the medicine of the present invention in treating arthritis is better than that of "Wantong Muscle and Bone Paste" and "Tonghua Wantong Pharmaceutical Co., Ltd." in treating arthritis. the
典型病例:台前县城关镇刘庙村,刘某某,女,现年56岁,2000年6月24号上午来诊,自述,两个膝关节和两个手关节都肿大,变形已经好几年了,中西药,封闭针、膏药都用过了,就是不好,听说你有一个秘方能治好关节肿大,故来诊。症见:两个膝关节肿大、变形、屈伸活动不利,拒按,疼痛,关节囊水肿,发热,左手食指、中指、无名指中间关节肿大、变形、屈伸活动不利,拒按,疼痛,右手中指、无名指中间关节肿大、变形、屈伸活动不利,拒按,疼痛,临床诊断为“关节炎”,咐其停用其它一切药物,改用本发明药物,随用碘伏棉棒把两个膝关节消毒,而后用酒精棉棒脱碘,按本发明使用方法贴在两个膝关节和两个手肿大的关节处,包好,一天换一次药,2000年6月25号上午又来诊,刘某某述,自贴上你发明的药后,到了昨天夜里感觉的两个膝关节和两个手关节有一种凉气往外出和热感觉,今天感觉两个膝关节和两个手关节疼的轻了,症见:肿轻了,用手按膝关节和两个手关节有弹性了,不热了,咐仍按上法换上新的药,明天再来,三诊,症见:两个膝关节和两个手关节基本上不疼了,肿大已基本消失,两膝关节和两个手关节能活动了,仍按上法换上新的药,明天再来,四诊,症见:两个膝关节和两个手关节不疼了,肿大已消失,两膝关节和两个手关节能伸直活动了,仍按上法换上新的药,明天再来,五诊,两个膝关节和两个手关节不疼了,肿大已全部消失,两膝关节和两个手关节能伸直活动自如了,皮肤已恢复正常弹性,刘某某述,两个膝关节和两个手关节不疼了,两腿也不发胀了,肿也消了,两膝关节和两个手关节活动自如了,症状全部消失了,也能下地干活了,问是否还用药,为防复发,让其再换上新的药,明天后拿掉,随访至今未复发。 Typical case: Liu XX, female, 56 years old, Liumiao Village, Chengguan Town, Taiqian County, came to the clinic on the morning of June 24, 2000. According to her self-report, both knee joints and two hand joints were swollen and deformed several times. It’s been a year, and I’ve used Chinese and Western medicine, sealing needles, and plasters, but it’s not good. I heard that you have a secret recipe that can cure joint swelling, so I came to see you. Symptoms: swelling and deformation of both knee joints, poor flexion and extension activities, refusal to press, pain, joint capsule edema, fever, swelling and deformation of the middle joints of the left index finger, middle finger, and ring finger, poor flexion and extension activities, refusal to press, pain, right hand The joints in the middle finger and ring finger are swollen, deformed, unfavorable in flexion and extension, refusal to press, pain, and the clinical diagnosis is "arthritis". Disinfect the knee joint, then deiodine it with alcohol cotton swab, paste it on the two knee joints and the swollen joints of the two hands according to the method of the present invention, wrap it up, change the medicine once a day, and came again in the morning of June 25, 2000 Doctor Liu stated that after applying the medicine you invented, the two knee joints and two hand joints felt cold and warm last night, and today the two knee joints and two hand joints felt cold. The pain in the joints is less, the symptoms are: the swelling is less, the knee joint and the two hand joints are elastic, and the heat is gone, I still follow the above method and change to a new medicine, come back tomorrow, the third visit, the symptoms are : The two knee joints and two hand joints are basically painless, the swelling has basically disappeared, the two knee joints and the two hand joints can move, and the new medicine is still replaced according to the above method. I will come back tomorrow for the fourth diagnosis. Symptoms: two knee joints and two hand joints are no longer painful, the swelling has disappeared, both knee joints and two hand joints can be straightened and moved, and the new medicine is still replaced according to the above method, come back tomorrow, five consultations , the two knee joints and two hand joints are no longer painful, the swelling has all disappeared, the two knee joints and two hand joints can be straightened and moved freely, and the skin has returned to normal elasticity. Liu Moumou said that the two knee joints The pain in the two hand joints and the two legs are no longer swollen, and the swelling has disappeared. The two knee joints and the two hand joints can move freely. , for preventing recurrence, let it change new medicine again, take off after tomorrow, follow up a case by regular visits to so far and no recurrence. the
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