CN103355298B - A kind of bactericidal composition containing fenhexamid and antibiotics - Google Patents
A kind of bactericidal composition containing fenhexamid and antibiotics Download PDFInfo
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- CN103355298B CN103355298B CN201210088025.2A CN201210088025A CN103355298B CN 103355298 B CN103355298 B CN 103355298B CN 201210088025 A CN201210088025 A CN 201210088025A CN 103355298 B CN103355298 B CN 103355298B
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- CN
- China
- Prior art keywords
- fenhexamid
- jinggangmeisu
- kasugarnycin
- antibiotics
- bactericidal composition
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- 239000005776 Fenhexamid Substances 0.000 title claims abstract description 141
- VDLGAVXLJYLFDH-UHFFFAOYSA-N fenhexamid Chemical compound C=1C=C(O)C(Cl)=C(Cl)C=1NC(=O)C1(C)CCCCC1 VDLGAVXLJYLFDH-UHFFFAOYSA-N 0.000 title claims abstract description 141
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 24
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 16
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 16
- 201000010099 disease Diseases 0.000 claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 32
- 239000000843 powder Substances 0.000 claims description 38
- 238000009736 wetting Methods 0.000 claims description 36
- 239000000375 suspending agent Substances 0.000 claims description 30
- 235000007164 Oryza sativa Nutrition 0.000 claims description 17
- 235000009566 rice Nutrition 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 13
- 239000003094 microcapsule Substances 0.000 claims description 13
- 239000004562 water dispersible granule Substances 0.000 claims description 11
- 239000004530 micro-emulsion Substances 0.000 claims description 9
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 5
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 241000223218 Fusarium Species 0.000 claims description 5
- 206010027146 Melanoderma Diseases 0.000 claims description 5
- 241000221696 Sclerotinia sclerotiorum Species 0.000 claims description 5
- 208000025865 Ulcer Diseases 0.000 claims description 5
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 16
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 230000000855 fungicidal effect Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
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- 238000012360 testing method Methods 0.000 description 25
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- 229910021641 deionized water Inorganic materials 0.000 description 20
- 238000002156 mixing Methods 0.000 description 19
- 241000209094 Oryza Species 0.000 description 16
- 230000003449 preventive effect Effects 0.000 description 16
- -1 chloro-4-hydroxy phenyl Chemical group 0.000 description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000000575 pesticide Substances 0.000 description 9
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- 230000002528 anti-freeze Effects 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
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- 206010067482 No adverse event Diseases 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
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- 231100000820 toxicity test Toxicity 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 3
- 244000241257 Cucumis melo Species 0.000 description 3
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- 229920001732 Lignosulfonate Polymers 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
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- 230000003115 biocidal effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- 239000003292 glue Substances 0.000 description 3
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- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000006353 oxyethylene group Chemical group 0.000 description 3
- 229910052625 palygorskite Inorganic materials 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
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- 244000215068 Acacia senegal Species 0.000 description 2
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010011732 Cyst Diseases 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
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- 239000013543 active substance Substances 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
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- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
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- VIESAWGOYVNHLV-UHFFFAOYSA-N 1,3-dihydropyrrol-2-one Chemical class O=C1CC=CN1 VIESAWGOYVNHLV-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- PYIXHKGTJKCVBJ-UHFFFAOYSA-N Astraciceran Natural products C1OC2=CC(O)=CC=C2CC1C1=CC(OCO2)=C2C=C1OC PYIXHKGTJKCVBJ-UHFFFAOYSA-N 0.000 description 1
- NDVRQFZUJRMKKP-UHFFFAOYSA-N Betavulgarin Natural products O=C1C=2C(OC)=C3OCOC3=CC=2OC=C1C1=CC=CC=C1O NDVRQFZUJRMKKP-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- IHPVFYLOGNNZLA-UHFFFAOYSA-N Phytoalexin Natural products COC1=CC=CC=C1C1OC(C=C2C(OCO2)=C2OC)=C2C(=O)C1 IHPVFYLOGNNZLA-UHFFFAOYSA-N 0.000 description 1
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- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
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- 239000000470 constituent Substances 0.000 description 1
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- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
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- 239000001923 methylcellulose Substances 0.000 description 1
- SFMJNHNUOVADRW-UHFFFAOYSA-N n-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamide Chemical compound C1=C(NC(=O)C=C)C(C)=CC=C1N1C(=O)C=CC2=C1C1=CC(C=3C=CC(NS(C)(=O)=O)=CC=3)=CC=C1N=C2 SFMJNHNUOVADRW-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
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- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000280 phytoalexin Substances 0.000 description 1
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- 238000003672 processing method Methods 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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- DJOJDHGQRNZXQQ-AWEZNQCLSA-N sakuranetin Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)OC)=CC=C(O)C=C1 DJOJDHGQRNZXQQ-AWEZNQCLSA-N 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing fenhexamid and antibiotics, bactericidal composition containing active components A and active component B, active components A is selected from fenhexamid, active component B is selected from any one compound following: jinggangmeisu, kasugarnycin, and the weight ratio of active components A and active component B is 1: 60 ~ 80: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, expands fungicidal spectrum.And have that dosage is little, resistance of rainwater washing against, the obvious feature of synergy.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition in crop pest containing fenhexamid and antibiotics.
Technical background
Fenhexamid (Fenhexamid) chemical name: N-(the chloro-4-hydroxy phenyl of 2,3-bis-)-1-methyl-cyclohexyl base formamide, molecular formula: C
14h
17cl
2nO
2.A kind of acid amide fungicides, seed treatment, seedling growing box inorganic agent, belongs to interior suction, protective fungicide.Different from existing bactericide, without bactericidal activity, do not suppress the growth of pathogen mycelia.Check melanin biosynthesis and can accelerate the generation of plant antibiotic as momilactoneA and sakuranetin after bacteria infection, this mechanism of action indication ring propionyl bacterium amine also may have activity to other diseases.Crop resistance is improved by increasing with paddy rice epidemic disease infects the phytoalexin of generation.
Jinggangmeisu (Jingangmycin) chemical name: N-[(1S)-(1,4,6/5)-3-methylol-4,5,6-trihydroxy-2-cyclohexenyl group] [O-β-D-glucopyranosyl-(1-3)]-1S-(1,2,4,3,5)-2,3,4-trihydroxy-5-methylol-cyclo-hexylamine, molecular formula: C
20h
35o
13n.Be the agricultural antibiotic that systemic action is very strong, after the mycelia of Rhizoctonia solani Kuhn touches jinggangmeisu, can absorbed by somatic cells very soon and conduct in thalline, interference and suppression somatic cells normal growth be grown, thus play therapeutic action.Jinggangmeisu also can be used for preventing and treating wheat sharp eyespot, false smut etc.
Kasugarnycin (Kasugamycin) chemical name: [5-amino-2-methyl-6-(2,3,4,5,6-carbonyl cyclohexyl oxo) pyrans-3-base amino-a-IMDA], molecular formula: C
14h
25n
3o
9.Be agricultural antibiotic, have stronger interior absorption, this medicine mainly disturbs amino acid whose metabolism esterase system, thus affects the synthesis of protein, suppresses hyphal elongation and causes cell granulations, but on spore germination without impact.
In the real process of agricultural production, the problem that controlling disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of synergy ratio.Study through inventor, find fenhexamid and jinggangmeisu, kasugarnycin mutually composite, have good synergistic effect within the specific limits, and about fenhexamid and jinggangmeisu, kasugarnycin relevant composite, there is not yet relevant report at home and abroad at present.
Summary of the invention
The object of the invention is to propose a kind ofly have that synergistic function, use cost are low, preventive effect is good containing the bactericidal composition of fenhexamid and antibiotics.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition containing fenhexamid and antibiotics, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1: 60 ~ 80: 1, described active components A is selected from fenhexamid, and active component B is selected from the one in jinggangmeisu, kasugarnycin.
The described bactericidal composition containing fenhexamid and antibiotics, is characterized in that: the weight ratio of active components A and active component B is 1: 30 ~ 40: 1.
The described bactericidal composition containing fenhexamid and antibiotics, is characterized in that: the weight ratio of fenhexamid and jinggangmeisu is 1: 10 ~ 20: 1.
The described bactericidal composition containing fenhexamid and antibiotics, is characterized in that: the weight ratio of fenhexamid and kasugarnycin is 1: 5 ~ 25: 1.
The described bactericidal composition containing fenhexamid and antibiotics, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, microemulsion, aqueous emulsion, microcapsule suspending agent, also can make suspension emulsion or microcapsule suspension-suspendinagent agent.
The described bactericidal composition containing fenhexamid and antibiotics is for preventing and treating the disease of crop, and described crop comprises vegetables, fruit tree, cereal crops, ornamental crops.
Described disease comprises rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, simultaneously also relevant with target disease.In usual composition, the weight percentage of active component is 0.1% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 0.1% ~ 60%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 0.1% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 2% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, stabilizing agent known in those skilled in the art, antifreeze etc. can also be contained.
Bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by processing method known in those skilled in the art, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc. by active component with liquid flux or solid carrier.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
Composition comprises following component and content when making wetting powder: active components A 0.1 ~ 80%, active component B0.1 ~ 60%, dispersant 1 ~ 12%, wetting agent 1 ~ 8%, filler surplus.
Composition comprises following component and content when making water dispersible granules: active components A 0.1 ~ 80%, active component B0.1 ~ 60%, dispersant 1 ~ 12%, wetting agent 1 ~ 8%, disintegrant 1 ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following component and content when making suspending agent: active components A 0.1 ~ 60%, active component B0.1 ~ 50%, dispersant 1 ~ 10%, wetting agent 1 ~ 10%, defoamer 0.1 ~ 2%, thickener 0.05 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following component and content when making suspension emulsion: active components A 0.1% ~ 60%, active component B0.1% ~ 50%, emulsifier 1% ~ 10%, dispersant 1% ~ 10%, solvent 0 ~ 20%, defoamer 0.1% ~ 2%, thickener 0.05% ~ 2%, antifreeze 0% ~ 8%, stabilizing agent 0% ~ 3%, deionized water add to 100%.
Composition comprises following component and content when making microemulsion: active components A 0.1% ~ 60%, active component B0.1% ~ 50%, emulsifier 1% ~ 15%, solvent 1% ~ 10%, antifreeze 0% ~ 8%, stabilizing agent 0% ~ 3%, defoamer 0.1% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making aqueous emulsion: active components A 0.1% ~ 60%, active component B0.1% ~ 50%, solvent 1% ~ 20%, emulsifier 1% ~ 12%, antifreeze 0% ~ 8%, defoamer 0.1% ~ 2%, thickener 0.05% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspending agent: active components A 0.1% ~ 60%, active component B0.1% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifier 1% ~ 7%, pH adjusting agent 0.1% ~ 5%, defoamer 0.1% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspension-suspendinagent agent: active components A 0.1% ~ 60%, active component B0.1% ~ 50%, macromolecule cyst material 1% ~ 12%, surfactant 2% ~ 15%, solvent 1% ~ 15%, emulsifier 1% ~ 8%, defoamer 0.1% ~ 2%, thickener 0.05% ~ 2%, pH adjusting agent 0.1% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose.
(2) pesticide usage amount reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution.
(3) fungicidal spectrum is expanded, to multiple diseases as rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold have greater activity.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 155% fenhexamid jinggangmeisu wetting powder
Fenhexamid 50%, jinggangmeisu 5%, octylphenol polyethylene oxyethylene group ether sulfate 3.8%, soapberry powder 4%, precipitated calcium carbonate add to 100%, and mixture carries out air-flow crushing, obtained 55% fenhexamid jinggangmeisu wetting powder.
Example 250% fenhexamid jinggangmeisu wetting powder
Fenhexamid 40%, jinggangmeisu 10%, polycarboxylate 4%, lauryl sodium sulfate 5%, kaolin add to 100%, and mixture carries out air-flow crushing, obtained 50% fenhexamid jinggangmeisu wetting powder.
Example 312% fenhexamid jinggangmeisu wetting powder
Fenhexamid 8%, jinggangmeisu 4%, alkylnaphthalene sulfonate 6.5%, neopelex 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, obtained 12% fenhexamid jinggangmeisu wetting powder.
Example 448% fenhexamid jinggangmeisu wetting powder
Fenhexamid 40%, jinggangmeisu 8%, aryl phenol polyoxyethylene succinate sulfonate 5.5%, sldium lauryl sulfate 6%, bentonite add to 100%, and mixture carries out air-flow crushing, obtained 48% fenhexamid jinggangmeisu wetting powder.
Example 515% fenhexamid jinggangmeisu wetting powder
Fenhexamid 10%, jinggangmeisu 5%, lignosulfonates 4.5%, wetting and penetrating agent F5%, precipitated calcium carbonate add to 100%, the obtained 15% fenhexamid jinggangmeisu wetting powder of mixing.
Example 636% fenhexamid jinggangmeisu wetting powder
Fenhexamid 32%, jinggangmeisu 4%, alkylphenol-polyethenoxy are phonetic 4.5%, silkworm excrement 5%, starch add to 100%, the obtained 36% fenhexamid jinggangmeisu wetting powder of mixing.
Example 76.1% fenhexamid jinggangmeisu water dispersible granules
Fenhexamid 0.1%, jinggangmeisu 6%, aliphatic amine polyoxyethylene are phonetic 4%, soapberry powder 5%, bentonite 2.5%, polyvinyl alcohol 0.06%, kaolin add to 100%, the obtained 6.1% fenhexamid jinggangmeisu water dispersible granules of mixing.
Example 810% fenhexamid jinggangmeisu suspending agent
Fenhexamid 5%, jinggangmeisu 5%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 4%, wetting and penetrating agent F4%, silicone oil 0.4%, gum Arabic 0.13%, diethylene glycol (DEG) 1%, deionized water add to 100%, the obtained 10% fenhexamid jinggangmeisu suspending agent of mixing.
Example 916% fenhexamid jinggangmeisu suspending agent
Fenhexamid 12%, jinggangmeisu 4%, naphthalene sulfonic acid-formaldehyde condensation product 4% spaonin powder 3.6%, organosilicon 0.3%, xanthans 0.11%, triethylene glycol 2%, deionized water add to 100%, the obtained 16% fenhexamid jinggangmeisu suspending agent of mixing.
Example 1021% fenhexamid jinggangmeisu suspending agent
Fenhexamid 20%, jinggangmeisu 1%, alkyl benzene sulfonate calcium salt 5.2%, silkworm excrement 4%, silicone 0.2%, melon glue 0.11%, deionized water add to 100%, the obtained 21% fenhexamid jinggangmeisu suspending agent of mixing.
Example 1120.5% fenhexamid jinggangmeisu microemulsion
Fenhexamid 20%, jinggangmeisu 0.5%, fatty alcohol-polyoxyethylene ether 3%, NOP 6%, propane diols 3%, silicone oil 0.2%, deionized water supply 100%, the obtained 20.5% fenhexamid jinggangmeisu microemulsion of mixing.
Example 1210.25% fenhexamid jinggangmeisu aqueous emulsion
Fenhexamid 0.25%, jinggangmeisu 10%, alkyl benzene calcium sulfonate 3.8%, N-pyrrolidones 5%, glycerine 5%, organosilicon 0.5%, melon glue 0.12%, deionized water supply 100%, obtained 10.25% fenhexamid jinggangmeisu aqueous emulsion.
Example 1310.5% fenhexamid jinggangmeisu microcapsule suspending agent
Fenhexamid 0.5%, jinggangmeisu 10%, sodium alginate 5%, polyoxyethylene carboxylate 5%, vegetable oil 4%, sorbitan fatty acid ester APEO 5%, hydrochloric acid 0.7%, sodium hydroxide 0.6%, silicone 0.4%, deionized water add to 100%, the obtained 10.5% fenhexamid jinggangmeisu microcapsule suspending agent of mixing.
Example 149% fenhexamid jinggangmeisu suspending agent
Fenhexamid 3%, jinggangmeisu 6%, soapberry powder 4%, lignosulfonates 4.4%, polyvinyl alcohol 0.13%, silicone 0.2%, deionized water add to 100%, the obtained 9% fenhexamid jinggangmeisu suspending agent of mixing.
Jinggangmeisu in example 1-14 is changed to kasugarnycin and can obtains novel formulation equally.
Example 1563% fenhexamid kasugarnycin wetting powder
The phonetic formaldehyde condensation products sulphate 4% of fenhexamid 60%, kasugarnycin 3%, alkylphenol-polyethenoxy, wetting and penetrating agent F5%, kaolin add to 100%, and mixture carries out air-flow crushing, obtained 63% fenhexamid kasugarnycin wetting powder.
Example 1624% fenhexamid kasugarnycin wetting powder
Fenhexamid 21%, kasugarnycin 3%, naphthalene sulfonic acid-formaldehyde condensation product 4.3%, neopelex 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, obtained 24% fenhexamid kasugarnycin wetting powder.
Example 1720% fenhexamid kasugarnycin wetting powder
Fenhexamid 16%, kasugarnycin 4%, polyoxyethylene carboxylate 3.3%, lauryl sodium sulfate 5%, diatomite add to 100%, and mixture carries out air-flow crushing, obtained 20% fenhexamid kasugarnycin wetting powder.
The agent of example 1833% fenhexamid kasugarnycin wetting powder
Fenhexamid 30%, kasugarnycin 3%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 4%, lauryl sodium sulfate 5%, attapulgite add to 100%, the obtained 33% fenhexamid kasugarnycin wetting powder of mixing.
Example 195.2% fenhexamid kasugamycin water-dispersion granule
Fenhexamid 0.2%, kasugarnycin 5%, octylphenol polyethylene oxyethylene group ether sulfate 5%, spaonin powder 5%, ammonium sulfate 3%, gelatin 0.05%, white carbon add to 100%, the obtained 5.2% fenhexamid kasugamycin water-dispersion granule of mixing.
Example 2024% fenhexamid kasugarnycin wetting powder
Fenhexamid 20%, kasugarnycin 4%, aryl phenol polyoxyethylene succinate sulfonate 4.5%, Nekal BX 5%, kaolin add to 100%, the obtained 24% fenhexamid kasugarnycin wetting powder of mixing.
Example 2112% fenhexamid kasugarnycin wetting powder
Fenhexamid 9%, kasugarnycin 3%, ester polyoxyethylene are phonetic 4.5%, silkworm excrement 5%, kaolin add to 100%, the obtained 12% fenhexamid kasugarnycin wetting powder of mixing.
Example 2227% fenhexamid kasugarnycin suspending agent
Fenhexamid 24%, kasugarnycin 3%, lignosulfonates 5.6%, tea are withered 3%, silicone 0.1%, gelatin 0.12%, deionized water add to 100%, the obtained 27% fenhexamid kasugarnycin suspending agent of mixing.
Example 2321% fenhexamid kasugarnycin suspending agent
Fenhexamid 18%, kasugarnycin 3%, alkylnaphthalene sulfonate 4.6%, alkylnaphthalene sulfonate 5%, acid amides 0.2%, melon glue 0.13%, deionized water add to 100%, the obtained 21% fenhexamid kasugarnycin suspending agent of mixing.
Example 2411% fenhexamid kasugarnycin suspending agent
Fenhexamid 1%, kasugarnycin 10%, octylphenol polyethylene oxyethylene group ether sulfate 4%, tea are withered 4%, acid amides 0.5%, gum Arabic 0.05%, deionized water add to 100%, the obtained 11% fenhexamid kasugarnycin suspending agent of mixing.
Example 2520.25% fenhexamid kasugarnycin microemulsion
Fenhexamid 20%, kasugarnycin 0.25%, castor oil polyoxyethylene ether 5.3%, polyethylene glycol 4.1%, acetone 4%, capric acid 0.25%, deionized water supply 100%, obtained 20.25% fenhexamid kasugarnycin microemulsion.
Example 2626% fenhexamid kasugarnycin aqueous emulsion
Fenhexamid 25%, kasugarnycin 1%, alkylphenol-formaldehyde resin polyoxyethyl ether 5%, ethylene glycol monomethyl ether 5%, methylcellulose 0.11%, propane diols 3%, silicone oil 0.15%, deionized water supply 100%, obtained 26% fenhexamid kasugarnycin aqueous emulsion.
Example 2730.5% fenhexamid kasugarnycin microcapsule suspending agent
Fenhexamid 30%, kasugarnycin 0.5%, alkylphenol-polyethenoxy are phonetic 4%, polyfunctional group acyl halide polyamines 4.5%, butyl ether 12%, alkylaryl polyoxyethylene poly-oxygen propylene aether 5%, sodium hydroxide 0.5%, citric acid 0.9%, organosilicon 0.4%, deionized water add to 100%, the obtained 30.5% fenhexamid kasugarnycin microcapsule suspending agent of mixing.
Example 2832% fenhexamid kasugarnycin suspending agent
Fenhexamid 30%, kasugarnycin 2%, alkylaryl APEO 6%, tea are withered 5%, CMC 0.1%, organosilicon 0.1%, deionized water add to 100%, the obtained 32% fenhexamid kasugarnycin suspending agent of mixing.
Kasugarnycin in example 15-28 is changed to jinggangmeisu and can obtains novel formulation equally.
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
Test method: determine that after the effective inhibition concentration scope of each medicament, medicament establishes 5 dosage process respectively by active constituent content through prerun, if clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter by right-angled intersection method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate the EC of often kind of medicament thus
50value.Calculate two medicament different ratio synergies ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and the ratio of active component B shared by combination;
A is fenhexamid;
B choosing is to the one in jinggangmeisu, kasugarnycin.
Application Example two:
For examination disease: wheat sharp eyespot.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fenhexamid and the former medicine of jinggangmeisu and the two different ratio mixture.
Toxicity test result
Table 1 fenhexamid and composite jinggangmycin are to the toxicity test analysis of results table of wheat sharp eyespot
As shown in Table 1, fenhexamid and jinggangmeisu proportioning are all greater than 1.5 to wheat sharp eyespot synergy ratio SR 1: 60 ~ 80: 1 time, both explanations mixture in 1: 60 ~ 80: 1 scope all shows synergistic effect, especially when the proportioning of fenhexamid and jinggangmeisu is 1: 10 ~ 20: 1 time, synergistic effect is more obviously given prominence to, test through applicant, the optimum ratio of discovery fenhexamid and jinggangmeisu is 20: 1, 15: 1, 10: 1, 9: 1, 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1: 10, wherein when fenhexamid and jinggangmeisu weight ratio are 2: 1, synergy ratio is maximum, synergistic effect is the most obvious.
Application Example three: for examination disease: rice blast.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fenhexamid and the former medicine of kasugarnycin and the two different ratio mixture.
Toxicity test result
Table 2 fenhexamid and the composite toxicity test analysis of results table to rice blast of kasugarnycin
As shown in Table 2, fenhexamid and kasugarnycin to the proportioning of rice blast 1: 60 ~ 80: 1 time, synergy ratio SR is all greater than 1.5, both explanations mixture in 1: 60 ~ 80: 1 scope all shows synergistic effect, especially when the proportioning of fenhexamid and kasugarnycin is 1: 5 ~ 25: 1 time, synergistic effect is more outstanding, test through applicant, the optimum ratio of discovery fenhexamid and kasugarnycin is 25: 1, 20: 1, 15: 1, 10: 1, 9: 1, 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, wherein when fenhexamid and kasugarnycin weight ratio are 5: 1, synergy ratio is maximum, synergistic effect is the most obvious.
In inventor's experimentation, find that fenhexamid and jinggangmeisu, the composite control to rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold of kasugarnycin have obvious synergistic effect.
Application Example four fenhexamid and jinggangmeisu, kasugarnycin and the composite water prevention rice sheath blight test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation rice sheath blight disease state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 3 fenhexamid and jinggangmeisu, kasugarnycin and the composite water prevention rice sheath blight test of pesticide effectiveness thereof
As can be seen from Table 3, can the effective water prevention rice sheath blight after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example five fenhexamid and jinggangmeisu, kasugarnycin and the composite control Brown patch disease test of pesticide effectiveness thereof
This test arrangement is in suburb, Xian District, Shanxi Province; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation Brown patch disease state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 4 fenhexamid and jinggangmeisu, kasugarnycin and the composite control Brown patch disease test of pesticide effectiveness thereof
As can be seen from Table 4, effectively can prevent and treat Brown patch disease after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example six fenhexamid and jinggangmeisu, kasugarnycin and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation rice blast state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 5 fenhexamid and jinggangmeisu, kasugarnycin and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 5, effectively can prevent and treat rice blast after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven fenhexamid and jinggangmeisu, kasugarnycin and composite control citrus bacterial canker disease thereof are imitated and are tested
This test arrangement is in Xianyang, Shanxi province city; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation citrus bacterial canker disease state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.Within after third time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 6 fenhexamid and jinggangmeisu, kasugarnycin and the composite control citrus bacterial canker disease test of pesticide effectiveness thereof
As can be seen from Table 6, effectively can prevent and treat citrus bacterial canker disease after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, fenhexamid and jinggangmeisu, the composite rear preventive effect to Common Diseases such as the rice blast in various crop, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray molds of kasugarnycin are all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. one kind contains the bactericidal composition of fenhexamid and antibiotics, it is characterized in that: effective active composition is active components A and active component B, active components A and active component B weight ratio are 1 ︰ 60 ~ 80 ︰ 1, and described active components A is fenhexamid, and active component B is jinggangmeisu.
2. the bactericidal composition containing fenhexamid and antibiotics according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 30 ~ 40 ︰ 1.
3. the bactericidal composition containing fenhexamid and antibiotics according to claim 2, is characterized in that: the weight ratio of fenhexamid and jinggangmeisu is 1 ︰ 10 ~ 20 ︰ 1.
4. any one according to claims 1 to 3 contains the bactericidal composition of fenhexamid and antibiotics, it is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, microemulsion, aqueous emulsion, microcapsule suspending agent.
5. the bactericidal composition containing fenhexamid and antibiotics according to claim 4 is for preventing and treating the application of crop pest.
6. application according to claim 5, is characterized in that: described disease is rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold.
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| CN106508937B (en) * | 2016-12-09 | 2018-11-23 | 山东省农业科学院植物保护研究所 | A kind of bactericidal composition and its application containing fenhexamid and Zhongshengmycin |
| CN107711857A (en) * | 2017-09-30 | 2018-02-23 | 京博农化科技股份有限公司 | A kind of bactericidal composition containing gliocladin and fenhexamid |
| CN109845738A (en) * | 2019-01-11 | 2019-06-07 | 山东省农业科学院植物保护研究所 | A kind of bactericidal composition containing cyclamycin and sulfazine and its application |
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| CN1132591A (en) * | 1994-10-17 | 1996-10-09 | 拜尔公司 | Mixture of fungicidally active compounds |
| CN1202798A (en) * | 1995-11-24 | 1998-12-23 | 巴斯福股份公司 | Fungicidal mixture |
| CN102017947A (en) * | 2010-12-15 | 2011-04-20 | 广西安泰化工有限责任公司 | Kasugamycin and validamycin composition and preparation thereof |
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| CN1094221A (en) * | 1993-04-28 | 1994-11-02 | 拜尔公司 | Composition of fungicidally active compounds |
| CN1132591A (en) * | 1994-10-17 | 1996-10-09 | 拜尔公司 | Mixture of fungicidally active compounds |
| CN1202798A (en) * | 1995-11-24 | 1998-12-23 | 巴斯福股份公司 | Fungicidal mixture |
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