CN103519828B - Analyte detection system and sensing label thereof - Google Patents

Abstract

The invention discloses an analyte detection system and its sensing label, comprising: a sensing label (101) embedded under the skin, the sensing label (101) has a magnetic elastic material coated with a biological enzyme (112) material (111), the biological enzyme (112) is used to react with the subcutaneous analyte to decompose the corresponding derivative substance, and the vibration frequency of the magnetic elastic material (111) changes with the concentration of the derivative substance; the magnetic A mass detector (102), configured to apply magnetic induction to the magnetoelastic material (111), and detect the vibration frequency of the magnetoelastic material (111), according to the correspondence between the prestored vibration frequency value and the concentration level of the analyte relationship to determine the corresponding analyte concentration level. With the invention, it can be worn conveniently, and the impact on the wearer's actions can be reduced.

Description

Analyte detection system and its sensing label

technical field

The invention relates to the field of medical testing, in particular to an analyte detection system and a sensing label thereof.

Background technique

At present, in the field of medical testing, testing for analytes has become very common. The analyte, such as the concentration of glucose in blood and body fluid, can be tested by using a dedicated tester with sensors. For example, a blood glucose meter can test the blood sugar concentration in human blood.

There are also analyte detection systems that can be implanted under the skin. For example, there is a continuous blood glucose monitoring system, which consists of a blood glucose recorder, an information extractor, an induction probe, cables, and blood glucose analysis software. The sensing probe is embedded under the skin of the patient, and there is a sensor on the sensing probe for sensing the blood sugar concentration value, which can detect the blood sugar concentration in the blood sugar and generate an electrical signal; the blood glucose recorder is connected to the probe through a cable, and every Receive an electrical signal every 10 seconds, store an average value every 5 minutes, and automatically record 288 blood sugar values every day. The continuous blood glucose monitoring system can automatically record the blood glucose level of the patient, and download the complete single-day blood glucose diagram, multi-day blood glucose diagram, pre-meal blood glucose diagram, specific time period blood glucose diagram and statistical data table report through the computer, from which you can understand the comprehensive blood glucose Information, discover many rules of hyperglycemia, hypoglycemia and blood sugar fluctuations that are not easy to find at ordinary times, provide valuable clinical basis for formulating and evaluating rationalized and individualized hypoglycemic treatment programs, and effectively help diabetic patients to educate and improve patients' awareness of diabetes awareness and compliance.

However, in the existing subcutaneously implanted analyte detection systems, corresponding sensors for detecting analyte levels are installed on the probes implanted under the skin. The sensors need to be driven by electricity, so the probes must be connected to The external information recorder is connected, and the power supply of the external information recorder and other equipment can work for a long time. Since the probe buried under the skin and the external equipment such as the information recorder need to be connected with a cable, it is very inconvenient for the wearer to move. There may even be accidents where the probe falls off due to unintentional dragging of the cable.

Contents of the invention

In view of this, the main purpose of the present invention is to provide an analyte detection system and its sensor label, which are easy to wear and reduce the impact on the wearer's actions.

In order to realize the above-mentioned purpose of the invention, the main technical solutions of the present invention are:

An analyte detection system comprising:

The sensing label (101), embedded under the skin, has a magnetic elastic material (111) coated with a biological enzyme (112) in the sensing label (101), and the biological enzyme (112) is used for analysis with the subcutaneous Decompose the corresponding derivative substances through the reaction of the substance, and the vibration frequency of the magnetoelastic material (111) changes with the concentration of the derivative substances;

A magnetic detector (102), configured to apply magnetic induction to the magnetoelastic material (111), and detect the vibration frequency of the magnetoelastic material (111), according to the prestored vibration frequency value and the concentration level of the analyte Corresponding relationship, determine the corresponding analyte concentration level.

In a preferred embodiment, the magnetic detector (102) specifically includes:

Timing module (121), used for triggering magnetic induction generation module (122) according to predetermined time interval;

A magnetic induction generating module (122), configured to apply magnetic induction to the magnetic elastic material (111) according to the trigger instruction of the timing module (121);

The detection module (123) is configured to detect the vibration frequency of the magnetoelastic material (111), and determine the corresponding analyte concentration level according to the pre-stored correspondence between the vibration frequency value and the analyte concentration level.

In a preferred embodiment, the system further includes: a signal recording device (103), communicating with the magnetic detector (102), for obtaining the analysis detected by the magnetic detector (102) analyte concentration level and save the analyte concentration level.

In a preferred embodiment, said system further comprises: a display for displaying said detected concentration level of said analyte.

In a preferred embodiment, the inner side of the magnetic detector (102) has an adhesive material (301) for sticking to the skin.

In a preferred embodiment, the analyte is glucose; the biological enzyme is glucose oxidase, and the glucose oxidase reacts with subcutaneous glucose to decompose acidic substances.

In a preferred embodiment, the system further includes a wireless communication interface communicating with a wireless network, for uploading the concentration level of the analyte to the cloud of the Internet.

A sensing tag, the sensing tag has a magnetic elastic material (111) coated with a biological enzyme (112), the magnetic elastic material (111) is used for embedding under the skin, and the biological enzyme (112) is used The vibration frequency of the magnetoelastic material (111) changes with the concentration of the derivative substance in order to decompose the corresponding derivative substance by reacting with the subcutaneous analyte.

In a preferred embodiment, the analyte is glucose; the biological enzyme is glucose oxidase, and the glucose oxidase reacts with subcutaneous glucose to decompose acidic substances.

Compared with the prior art, in the present invention, the biological enzyme can react with the subcutaneous analyte to decompose the corresponding derivative substance, and the derivative substance can cause the mass and/or volume of the magnetic elastic material to expand or shrink. , thereby changing the vibration frequency of the magnetoelastic material, so that the vibration frequency of the magnetoelastic material changes with the concentration of the derivative substance. The magnetic detector may itself have a magnetic field. If it is necessary to detect the concentration level of the analyte in the human body, the magnetic detector is placed close to the skin embedded with the sensor label, and the magnetic detector will Applying its own magnetic field to the sensing label causes the sensing label to vibrate, and then detects the vibration frequency of the magnetoelastic material, and finally determines the corresponding analyte concentration level. Therefore, the sensor tag of the present invention can work without power drive, and does not need cables to power the sensor tag, which is very convenient to wear. The patient only needs to embed the sensor tag under the skin, and the magnetic detector is placed in the pocket of the clothes When it is necessary to detect the corresponding concentration level of the analyte in the body, it is only necessary to place the magnetic detector close to the skin where the sensing label is embedded. Therefore, the wearer can move freely after wearing the sensing tag, without worrying that the cables hinder the movement.

Description of drawings

1 is a schematic diagram of the composition of an embodiment of the analyte detection system of the present invention;

Fig. 2 is a schematic composition diagram of another embodiment of the analyte detection system of the present invention;

Fig. 3 is a schematic composition diagram of another embodiment of the analyte detection system of the present invention;

Fig. 4 is a schematic composition diagram of another embodiment of the analyte detection system of the present invention.

Detailed ways

The present invention will be further described in detail below through specific embodiments and accompanying drawings.

Fig. 1 is a schematic composition diagram of an embodiment of the analyte detection system of the present invention. Referring to Figure 1, the analyte detection system specifically includes:

The sensing tag 101 is embedded under the skin. The subcutaneous refers to under the wearer's skin. As shown in FIG. 1 , the sensing tag 101 is embedded under the skin 100 . The sensor tag 101 has a magnetic elastic material 111 coated with a biological enzyme 112. The biological enzyme 112 is used to react with the subcutaneous analyte to decompose the corresponding derivative substance. The vibration frequency of the magnetic elastic material 111 varies with a change in the concentration of said derivative substance;

The magnetic detector 102 is configured to apply magnetic induction to the magnetoelastic material 111, detect the vibration frequency of the magnetoelastic material 111, and determine the corresponding Analyte concentration levels.

In the present invention, the biological enzyme can react with the subcutaneous analyte to decompose the corresponding derivative substance, and the derivative substance can cause the mass and/or volume of the magnetoelastic material to expand or shrink, thereby changing the magnetoelastic material The vibration frequency of the magnetoelastic material changes with the concentration of the derivative substance. The magnetic detector may itself have a magnetic field. If it is necessary to detect the concentration level of the analyte in the human body, the magnetic detector is placed close to the skin embedded with the sensor label, and the magnetic detector will Applying its own magnetic field to the sensing label causes the sensing label to vibrate, and then detects the vibration frequency of the magnetoelastic material, and finally determines the corresponding analyte concentration level. Therefore, the sensor tag of the present invention can work without power drive, and does not need cables to power the sensor tag, which is very convenient to wear. The patient only needs to embed the sensor tag under the skin, and the magnetic detector is placed in the pocket of the clothes When it is necessary to detect the corresponding concentration level of the analyte in the body, it is only necessary to place the magnetic detector close to the skin where the sensing label is embedded. Therefore, the wearer can move freely after wearing the sensing tag, without worrying that the cables hinder the movement.

The analyte may be any subcutaneous analyte, such as glucose level, ketone body level, acid or base level and the like.

In a typical application embodiment, the analyte detection system may be a blood glucose detection system, and in this embodiment, the analyte is glucose; the biological enzyme may be glucose oxidase, and the glucose Oxidase reacts with subcutaneous glucose to break down acidic substances. The acidic substance can expand the magnetoelastic material, causing its vibration frequency to change. Generally speaking, the higher the glucose concentration in the body, the more acidic substances are decomposed, the greater the expansion of the magnetoelastic material, and the greater the corresponding change in its vibration frequency. Then the vibration frequency has a corresponding relationship with the glucose concentration value in the body, and the subcutaneous glucose concentration value has a direct corresponding relationship with the blood sugar value, so this corresponding relationship is stored in the magnetic detector 102 in advance, and the magnetic substance The detector 102 can detect the vibration frequency of the sensor tag 101 without being connected with the sensor tag 101, and then can obtain the corresponding glucose concentration value and blood sugar value according to the detected vibration frequency, thus realizing the detection of the blood sugar value of the human body. detection.

Fig. 2 is a schematic composition diagram of an embodiment of the analyte detection system of the present invention. Referring to FIG. 2, in this embodiment, the magnetic detector 102 specifically includes:

A timing module 121, configured to trigger the magnetic induction generating module 122 according to a predetermined time interval;

A magnetic induction generating module 122, configured to apply magnetic induction to the magnetic elastic material 111 according to the trigger instruction of the timing module 121;

The detection module 123 is configured to detect the vibration frequency of the magnetoelastic material 111, and determine the corresponding analyte concentration level according to the pre-stored correspondence between the vibration frequency value and the analyte concentration level.

This embodiment enables dynamic monitoring of analyte concentration levels in vivo. For example, the magnetic detector can be fixed on the skin with the sensor tag embedded with a material other than the present invention, such as adhesive plaster, and then the timing module will set the time interval according to a predetermined time interval (such as every 30 seconds) ) triggers the magnetic induction generating module, and the magnetic induction generating module applies magnetic induction to the magnetic elastic material under the skin, and the detection module detects the subcutaneous analyte concentration level according to the vibration frequency of the magnetic elastic material, so that it can be detected every 30 seconds to obtain a The subcutaneous analyte concentration level value forms a dynamic monitoring of the subcutaneous analyte concentration level.

For example, if the analyte is glucose and the concentration level of the analyte is the blood sugar level, then the present invention can realize the dynamic monitoring of the patient's blood sugar level, that is, the patient's current real-time blood sugar will be monitored every 30 seconds, which is beneficial to diabetes. Blood sugar control is extremely important, and patients or doctors can adjust the treatment plan in time according to these real-time blood sugar values, so as to keep the blood sugar levels of patients within the normal range and improve the health level of patients.

Fig. 3 is a schematic composition diagram of another embodiment of the analyte detection system of the present invention. Referring to FIG. 3 , in this embodiment, in order to further facilitate the patient to wear the magnetic detector 102 , the inner side of the magnetic detector 102 has an adhesive material 301 for adhering to the skin. In this way, it is not necessary to use external adhesive tape to paste the magnetic detector 102 .

Fig. 4 is a schematic composition diagram of another embodiment of the analyte detection system of the present invention. Referring to FIG. 4, in this embodiment, the system further includes: a signal recording device 103, which can realize wired or wireless communication with the magnetic detector 102, and is used to obtain the signal detected by the magnetic detector 102. The concentration level of the analyte is stored, and the concentration level of the analyte is saved, so that the user can view the historical concentration level of the analyte at a later stage.

On the basis of the above embodiment in FIG. 2 or FIG. 3 , the system may further include a display for displaying the detected concentration level of the analyte.

On the basis of any one of the above embodiments, the system may further include a wireless communication interface communicating with a wireless network, for uploading the concentration level of the analyte to the cloud of the Internet. The wireless communication interface can be directly connected to the magnetic detector 102. After the magnetic detector 102 detects the concentration level of the analyte, the wireless communication interface uploads the concentration level of the analyte to the cloud of the Internet in real time. Alternatively, the wireless communication interface can also be connected to the information recording device 102, and the analyte concentration level recorded by the information recording device can be uploaded to the cloud of the Internet in real time or periodically. After uploading to the cloud, telemedicine can be realized, and doctors can log in to the cloud to download the data of the concentration level of the analyte, and accordingly propose a reasonable treatment plan for the patient.

The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person familiar with the technology can easily think of changes or replacements within the technical scope disclosed in the present invention. , should be covered within the protection scope of the present invention.

Claims (8)

1. An analyte detection system, characterized in that the system comprises: The sensing label (101), embedded under the skin, has a magnetic elastic material (111) coated with a biological enzyme (112) in the sensing label (101), and the biological enzyme (112) is used for analysis with the subcutaneous Decompose the corresponding derivative substances through the reaction of the substance, and the vibration frequency of the magnetoelastic material (111) changes with the concentration of the derivative substances; A magnetic detector (102), configured to apply magnetic induction to the magnetoelastic material (111), and detect the vibration frequency of the magnetoelastic material (111), according to the prestored vibration frequency value and the concentration level of the analyte Corresponding relationship, determine the corresponding analyte concentration level; The analyte is glucose. 2. The system according to claim 1, characterized in that, the magnetic detector (102) specifically comprises: Timing module (121), used for triggering magnetic induction generation module (122) according to predetermined time interval; A magnetic induction generating module (122), configured to apply magnetic induction to the magnetic elastic material (111) according to the trigger instruction of the timing module (121); The detection module (123) is configured to detect the vibration frequency of the magnetoelastic material (111), and determine the corresponding analyte concentration level according to the pre-stored correspondence between the vibration frequency value and the analyte concentration level. 3. The system according to claim 2, characterized in that, the system further comprises: a signal recording device (103), communicating with the magnetic detector (102), for acquiring the magnetic detector ( 102) The detected analyte concentration level, and save the analyte concentration level. 4. The system according to claim 2, wherein the system further comprises: a display for displaying said detected concentration level of said analyte. 5. The system according to claim 1, characterized in that, the inner side of the magnetic detector (102) has an adhesive material (301) for adhering to skin. 6. The system according to any one of claims 1 to 5, characterized in that, The biological enzyme is glucose oxidase, and the glucose oxidase reacts with subcutaneous glucose to decompose acidic substances. 7. The system according to any one of claims 1 to 5, characterized in that the system further comprises a wireless communication interface communicating with a wireless network, for uploading the concentration level of the analyte to the cloud of the Internet. 8. A sensor tag, characterized in that the sensor tag has a magnetic elastic material (111) coated with a biological enzyme (112), and the magnetic elastic material (111) is used for embedding under the skin, the The biological enzyme (112) is used to react with the subcutaneous analyte to decompose the corresponding acidic substance, and the vibration frequency of the magnetic elastic material (111) changes with the concentration of the acidic substance.