CN103549992B - The method that targeting cutter mist feeder and control cold export - Google Patents
The method that targeting cutter mist feeder and control cold export Download PDFInfo
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- 101100006584 Mus musculus Clnk gene Proteins 0.000 claims description 34
- 229910052757 nitrogen Inorganic materials 0.000 claims description 26
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 24
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Abstract
The present invention relates to a kind of method of targeting cutter mist feeder and the output of control cold, this device comprises two steel cylinders, two gas flow controllers, mixing chamber, high-pressure controller, high-pressure solenoid valve, low pressure controller, low-voltage solenoid valve, controller, chilldown system and targeting cuttves.For having the gas with various of positive Joule-Thomsan effect (coefficient) in two steel cylinders, gas flows out by steel cylinder, after flow controller adjust flux, enter mixing chamber fully mix, successively through pressure controller and electromagnetic valve, after entering chilldown system pre-cooling, flow to targeting district place's throttling refrigeration.The present invention regulates the different flow of gas in two steel cylinders by controller, realizes the mixing of two kinds of any mixing ratios of gas, makes full use of N
2, Ar throttling refrigeration characteristic, the cold of accurate control inputs cutter head, different refrigeration requirement when adapting to different parts tumor cryoablation, improves the effective rate of utilization of chilldown system cold and saves source of the gas, relieve patient ' s burden while ensureing cryoablation effect.
Description
Technical field
The present invention relates to a kind of mist feeder of tumor cryoablation targeting cutter and control the method that cold exports, after being used for making the targeting district of targeting cutter to be down to fast melting temperature, the cold in control inputs targeting district.
Background technology
2010, malignant tumor became the disease that fatality rate is the highest in the world.If held fire, will there be 2,600 ten thousand new cases in the expectation the year two thousand thirty whole world, and death toll reaches 1,700 ten thousand people.Because only having the tumor patient of about about 20% to accept surgical resection, the tumor micro-wound treatment technologies such as cryoablation, radio-frequency (RF) ablation, microwave, laserthermia are just becoming the forward position of contemporary clinical medical development, and cryoablation wherein a kind ofly has the technology representing meaning.It is mainly through cryosurgery tool, controlledly makes that lesion tissue experience is lowered the temperature, freezed, rewarming process, thus causes the irreversible damage of tumor cell even downright bad.The kill mechanism of cryoablation to tumor cell is: cell dehydration and shrinkage; The mechanical damage that intracellular ice crystal is formed; Cell electrolyte toxicity is concentrated to be changed with pH value; The degeneration of cell membrane protein composition; Blood stagnation and microthrombusis; And immunological effect etc.Cryoablation not only operation wound is little, and has that registration, hemostatic analgesia, post-operative complication are few, safety advantages of higher, the dark favorable comment by numerous doctors and patient.
The large class of the main atmosphere two of Cryoablation system of having come out at present a: class is liquid nitrogen system targeting cutter, needs the principle absorbing a large amount of latent heats of vaporization to make to organize fast cooling when utilizing material to become gas by liquid; Another kind of is gas throttling system targeting cutter, and the change of temperature when utilizing gases at high pressure to flow through aperture adiabatic throttling, what complete cryoablation falls rewarming therapeutic process.Liquid nitrogen system targeting cutter can regard first generation targeting cutter as, has following shortcoming: cutter head cooling rate is comparatively slow, is unfavorable for killing of tumor cell; Targeting cutter diameter is comparatively large, is unfavorable for minimally-invasive treatment; Equipment volume is huger, and liquid nitrogen storage needs special equipment, is not easy to transport.Gas throttling system targeting cutter is the main flow of current clinical practice, and representative products is argon helium knife, can regard second filial generation targeting cutter as.It uses argon throttling cooling, helium heats up, and has the advantages such as device small volume and less weight, cutter head heating and cooling are rapid.But required argon bottle pressure is up to 5000psi, transport and all there is certain potential safety hazard when using, and argon, helium are rare gas, and price is higher and be difficult to buy.
Nitrogen throttling targeting cutter can regard third generation targeting cutter as, and nitrogen operating pressure is 1200psi, and storage pressure is 2100psi, is the standing gas of hospital.But reach treatment temperature to nitrogen throttling targeting cutter, must to nitrogen precooled, the nitrogen after pre-cooling is cooled to treatment temperature in the targeting district throttling of targeting cutter again.According to the Analysis on Thermodynamic Properties of nitrogen, the simple dependency of nitrogen throttling targeting cutter to chilldown system is stronger, the rising of precooling temperature when working with targeting cutter, the targeting district of targeting cutter can not maintain required low temperature, many targeting cutter use in conjunction time, this phenomenon will more early occur, have a strong impact on the scope of application of ablation effect and targeting cutter.According to argon as working medium, above-mentioned situation has comparatively significantly to be improved, but the argon throttling initial stage, cooling rate is slow, and cryoablation is when starting, because tumor tissues blood is for abundant, thermic load is very large, need the hemoperfusion heat of very large cold ability Tumor suppression tissue, and quick freezing tumor tissues.Meanwhile, with the carrying out of ablation procedure, the blood vessel major part in tumor tissues is freezed, and blood is for significantly reducing, and targeting district outer wall is surrounded by ice hockey, and cold very little in cutter can reach thermal balance with in-house thermic load, makes targeting district temperature remain stable.Now, excessive gas flow can not make tool temperature reduce further, can cause a large amount of wastes of chilldown system cold and gas on the contrary.This phenomenon, all gas throttling refrigeration systems for tumor cryoablation all exist.Therefore, that simple is the nitrogen (N after targeting cutter supply pre-cooling
2) or argon (Ar), or there is cold deficiency or there is the initial stage and to lower the temperature the problem such as slow, all effectively can not adapt to clinical practice needs, cause the waste of resource and the financial burden of making patients.
Summary of the invention
The present invention is directed to deficiency and the actual demand of the existence of existing gas throttling refrigeration system, provide a kind of feeder of mist and control the method for cold output, this apparatus structure is simple, facilitates easy-to-use; The method can make full use of the restriction characteristic of each positive Jiao-Tang gas, while guarantee targeting district fast cooling reduces again the dependence to chilldown system, the cold in accurate control inputs targeting district, cutter head is maintained in treatment temperature with less gas flow, improve the effective rate of utilization of chilldown system cold, ensure therapeutic effect during multitool coupling.
In order to solve the problems of the technologies described above, the technical scheme of employing of the present invention is:
A kind of targeting cutter mist feeder, comprise steel cylinder A, steel cylinder B, gas flow controller A, gas flow controller B, mixing chamber, high-pressure controller, low pressure controller, high-pressure solenoid valve, low-voltage solenoid valve, controller, chilldown system and targeting cutter, be characterized in: in steel cylinder A and steel cylinder B, nitrogen and argon are housed respectively, steel cylinder A and steel cylinder B is respectively by flow controller A3, flow controller B4 connects mixing chamber, in mixing chamber, the nitrogen of mixing is divided into two tunnels with the mist escape pipe of argon: a road is connected chilldown system through high-pressure controller with high-pressure solenoid valve, another road is connected chilldown system through low pressure controller with low-voltage solenoid valve, chilldown system connects targeting cutter, flow controller A, flow controller B, high-pressure solenoid valve, low-voltage solenoid valve are connected with controller respectively.
Concentration expressed in percentage by volume range of accommodation in mixing chamber shared by nitrogen is between 0% ~ 100%.High-pressure controller output pressure set point is between 1500psi ~ 1800psi; Low pressure controller output pressure set point is between 800psi ~ 1200psi.Mist enter targeting cutter before through chilldown system (temperature of pre-cooling for≤-80 DEG C.Targeting cutter includes targeting district, and the quantity of described targeting cutter is 1 ~ 8.
Utilize above-mentioned targeting cutter mist feeder to control a method for cold output, comprise three kinds of methods:
First method: select " pressure adjustment " pattern first on the controller, now, high-pressure solenoid valve is opened, low-voltage solenoid valve is closed, the targeting district fast cooling of targeting cutter, and after 3 minutes, low-voltage solenoid valve is opened, high-pressure solenoid valve is closed, make targeting cutter mist feeder export mist with low pressure, reduce targeting district cold, keep targeting district temperature-resistant simultaneously.
Second method: select " power adjustments " pattern setpoint power output to be any number between 0% ~ 100% first on the controller, setting low-voltage solenoid valve is closed, high-pressure solenoid valve is opened or high-pressure solenoid valve is closed, low-voltage solenoid valve is opened, during the work of targeting cutter, the low-voltage solenoid valve of unlatching or high-pressure solenoid valve export mist to targeting district by regulating the mode of dutycycle according to setting power value.
The third method: select " mixing ratio adjustment " pattern first on the controller, setting low-voltage solenoid valve is closed, high-pressure solenoid valve is opened or high-pressure solenoid valve is closed, low-voltage solenoid valve is opened, first 5 minutes of targeting cutter work, concentration expressed in percentage by volume in mixing chamber shared by nitrogen is set as any number between 51% ~ 100% by controller, middle 5 minutes, concentration expressed in percentage by volume in mixing chamber shared by nitrogen is set as 50% by controller, last 5 minutes, the concentration expressed in percentage by volume in mixing chamber shared by nitrogen was set as any number between 0% ~ 49% by controller.
The invention has the beneficial effects as follows:
The main feature of targeting cutter mist feeder of the present invention is: this device comprises the flow controller of steel cylinder and respective amount, the mixing ratio mixing indoor gas can be controlled easily by flow controller, to give full play to gas with various restriction characteristic, adapt to the actual of different parts tumor and melt demand; This device, with high-pressure controller, high-pressure solenoid valve composition gases at high pressure path, forms low-pressure gas path with low pressure controller and low-voltage solenoid valve.By cut-offfing of corresponding electromagnetic valve, gas line pressure or freezing power can be controlled, the fast cooling in targeting cutter targeting district when realizing melting beginning, and gas flow less after targeting district temperature stabilization, thus while saving gas, utilize the cold of gas chilldown system more efficiently.
Another feature of targeting cutter mist feeder of the present invention is: be respectively N in two steel cylinders
2and Ar.By controlling the mixing ratio of two kinds of gases in ablation procedure, can the cold in control inputs targeting district and cooling rate, to adapt to different parts tumor and same region tumors difference melts the different demands of stage to cold.Such as, melt the refrigeration capacity requirement such as liver, lung large and require the tumor of fast cooling, increase N
2ratio, melts the refrigeration capacity requirement such as mammary gland little but require the tumor of the accurate not damaging normal tissue of temperature control, then increases Ar ratio.
Another feature of targeting cutter mist feeder of the present invention is: the high-pressure controller output pressure of this device can be set as 1500psi ~ 1800psi; Low pressure controller output pressure can be set as 800psi ~ 1200psi.Coordinate the mist of different proportion, realize the fast cooling in targeting district with gases at high pressure, then maintain targeting district temperature with the gas of suitable low pressure, improve the effective rate of utilization of chilldown system cold.
The maximum advantage of the present invention is, the targeting cutter mist feeder overall structure provided is simple, can easily with any mixing ratio mixing two gas, give full play to advantage during gas with various throttling cooling, and the size of situation adjustments of gas output pressure, freezing power or gas mixture ratio can be melted according to actual; In conjunction with three kinds of methods that control cold provided by the invention exports, the fast cooling in targeting district can be realized, and the accurate control to input targeting district cold, improve the effective rate of utilization of chilldown system cold and save source of the gas, meeting the needs of multitool coupling clinically.
Accompanying drawing explanation
Fig. 1 is the structural representation of targeting cutter mist feeder of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing 1 and specific embodiment, set forth the present invention further.These embodiments are interpreted as only being not used in for illustration of the present invention limiting the scope of the invention.After the content of having read the present invention's record, those skilled in the art can make various changes or modifications the present invention, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.
As shown in Figure 1, targeting cutter mist feeder of the present invention, comprises steel cylinder A1, steel cylinder B2, gas flow controller A3, gas flow controller B4, mixing chamber 5, high-pressure controller 6, low pressure controller 7, high-pressure solenoid valve 8, low-voltage solenoid valve 9, controller 10, chilldown system 11 and targeting cutter 12.
In steel cylinder A1 and steel cylinder B2, nitrogen and argon are housed respectively, steel cylinder A1 is connected mixing chamber 5 with steel cylinder B2 respectively by flow controller A3, flow controller B4, in mixing chamber 5, the nitrogen of mixing is divided into two tunnels with the mist escape pipe of argon: a road is connected chilldown system 11 through high-pressure controller 6 with high-pressure solenoid valve 8, another road is connected chilldown system 11 through low pressure controller (7) with low-voltage solenoid valve 9, and chilldown system 11 connects targeting cutter 12; Flow controller A3, flow controller B4, high-pressure solenoid valve 8, low-voltage solenoid valve 9 are connected with controller 10 respectively.
Concentration expressed in percentage by volume range of accommodation in mixing chamber 5 shared by nitrogen is between 0% ~ 100%.High-pressure controller 6 output pressure set point is between 1500psi ~ 1800psi; Low pressure controller 7 output pressure set point is between 800psi ~ 1200psi.Mist enter before targeting cutter (12) through the temperature of chilldown system 11 pre-cooling for≤-80 DEG C.Targeting cutter 12 includes targeting district 13, and the quantity of targeting cutter 12 is 1 ~ 8.
There is in steel cylinder A1 and steel cylinder B2 the gas with various of positive Joule-Thomsan effect (coefficient), gas flows out by steel cylinder A1, steel cylinder B2, after flow controller A3, flow controller B4 adjust flux, enter mixing chamber 5 respectively fully to mix, successively through high-pressure controller 6, low pressure controller 7, high electromagnetic valve 8 and low-voltage solenoid valve 9, after entering chilldown system 8 pre-cooling, flow to targeting district 13 place's throttling refrigeration.
What the preferred embodiment of the present invention provided utilizes the method for targeting cutter mist feeder control cold output to have three kinds:
Method one. select " pressure adjustment " pattern on the controller, setting high-pressure controller output pressure is 1500psi, and setting low pressure controller output pressure is 1200psi, setting N
2shared concentration expressed in percentage by volume is 50%.When melting beginning, high-pressure solenoid valve is opened, and low-voltage solenoid valve is closed, targeting district fast cooling, makes the surrounding tissue quick freezing of targeting district form the ice hockey of certain volume.After 3min, low-voltage solenoid valve is opened, and high-pressure solenoid valve is closed, and device exports mist with low pressure, effectively reduces gas flow, and targeting district temperature is still constant.This pattern is applicable to melt the deep tumor that liver, lung etc. need fast cooling and larger refrigerating capacity.
Method two. select " power adjustments " pattern on the controller, setpoint power output is 50%, setting N
2shared concentration expressed in percentage by volume is 40%, and setting high-pressure solenoid valve is closed, and low-voltage solenoid valve is opened, and setting low pressure controller output pressure is 1100psi.Now, low-voltage solenoid valve unlatching in the cycle period of setting, the time of closing respectively account for half, thus make in ablation procedure, and feeder only has the time of half to be targeting cutter air feed, decreases the gas consumption of half.This pattern is applicable to prostate etc. needs cold less, and to wish to lower the temperature comparatively mild tumor for protection closes on vital tissue.
Under " power adjustments " pattern, if three use targeting cutter simultaneously, can setpoint power output be 33%, setting N
2shared concentration expressed in percentage by volume is 60%, and setting high-pressure solenoid valve is opened, and low-voltage solenoid valve is closed, and setting high-pressure controller output pressure is 1600psi.After melting beginning, three targeting cuttves open successively and cut out in the cycle period of setting, be 33% of setting cycle period the interval time of opening, now, although be that three targeting cuttves use simultaneously, but in fact the same time only have a targeting cutter in work, significantly can reduce the effect that gas consumption also ensures to melt.
Method three. select " mixing ratio adjustment " pattern on the controller, setting low-voltage solenoid valve is opened, and high-pressure solenoid valve is closed, and setting low pressure controller output pressure is 1000psi.5 minutes N of beginning are melted in setting
2shared percent by volume is 80%, subsequently 5 minutes, setting N
2shared concentration expressed in percentage by volume is 50%, last 5 minutes that melt, setting N
2shared concentration expressed in percentage by volume is 20%.This pattern is applicable to mammary gland etc. needs that cold is slightly large, cooling is slightly fast, needs again accurate temperature controlling to prevent the superficial tumor of cold injury epidermal tissue.
Claims (8)
1. a targeting cutter mist feeder, comprise steel cylinder A(1), steel cylinder B(2), gas flow controller A(3), gas flow controller B(4), mixing chamber (5), high-pressure controller (6), low pressure controller (7), high-pressure solenoid valve (8), low-voltage solenoid valve (9), controller (10), chilldown system (11) and targeting cutter (12), it is characterized in that: described steel cylinder A(1) and steel cylinder B(2) in nitrogen and argon are housed respectively, steel cylinder A(1) by flow controller A(3), steel cylinder B(2) by flow controller B(4) connect mixing chamber (5) respectively, in mixing chamber (5), the nitrogen of mixing is divided into two tunnels with the mist escape pipe of argon: a road is connected chilldown system (11) through high-pressure controller (6) with high-pressure solenoid valve (8), another road is connected chilldown system (11) through low pressure controller (7) with low-voltage solenoid valve (9), chilldown system (11) connects targeting cutter (12), described flow controller A(3), flow controller B(4), high-pressure solenoid valve (8), low-voltage solenoid valve (9) be connected with controller (10) respectively.
2. targeting cutter mist feeder according to claim 1, is characterized in that: the concentration expressed in percentage by volume range of accommodation shared by described mixing chamber (5) interior nitrogen is between 0% ~ 100%.
3. targeting cutter mist feeder according to claim 1, is characterized in that: described high-pressure controller (6) output pressure set point is between 1500psi ~ 1800psi; Low pressure controller (7) output pressure set point is between 800psi ~ 1200psi.
4. the targeting cutter mist feeder according to claim 1, is characterized in that: described mist enter before targeting cutter (12) through the temperature of chilldown system (11) pre-cooling for≤-80 DEG C.
5. the targeting cutter mist feeder according to claim 1, is characterized in that: described targeting cutter (12) includes targeting district (13), and the quantity of described targeting cutter (12) is 1 ~ 8.
6. the method utilizing the targeting cutter mist feeder of claim 1-5 described in any one to control cold to export, it is characterized in that: first in the upper selection of controller (10) " pressure adjustment " pattern, now, high-pressure solenoid valve (8) is opened, low-voltage solenoid valve (9) is closed, targeting district (13) fast cooling of targeting cutter (12), after 3 minutes, low-voltage solenoid valve (9) is opened, high-pressure solenoid valve (8) is closed, targeting cutter mist feeder is made to export mist with low pressure, reduce targeting district (13) cold, keep targeting district (13) temperature-resistant simultaneously.
7. the method utilizing the targeting cutter mist feeder of claim 1-5 described in any one to control cold to export, it is characterized in that: first select " power adjustments " pattern and setpoint power output is any number between 0% ~ 100% controller (10) is upper, setting low-voltage solenoid valve (9) is closed, high-pressure solenoid valve (8) is opened or high-pressure solenoid valve (8) is closed, low-voltage solenoid valve (9) is opened, during targeting cutter (12) work, the low-voltage solenoid valve (9) opened or high-pressure solenoid valve (8) export mist to targeting district (13) by regulating the mode of dutycycle according to setting power value.
8. the method utilizing the targeting cutter mist feeder of claim 1-5 described in any one to control cold to export, it is characterized in that: first in the upper selection of controller (10) " mixing ratio adjustment " pattern, setting low-voltage solenoid valve (9) is closed, high-pressure solenoid valve (8) is opened or high-pressure solenoid valve (8) is closed, low-voltage solenoid valve (9) is opened, targeting cutter (12) first 5 minutes of working, concentration expressed in percentage by volume shared by mixing chamber (5) interior nitrogen is set as any number between 51% ~ 100% by controller (10), middle 5 minutes, concentration expressed in percentage by volume shared by mixing chamber (5) interior nitrogen is set as 50% by controller (10), last 5 minutes, concentration expressed in percentage by volume shared by mixing chamber (5) interior nitrogen is set as any number between 0% ~ 49% by controller (10).
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| CN105902310B (en) * | 2016-04-11 | 2018-07-06 | 天津美电医疗科技有限公司 | Cryosurgery device for adjusting air pressure to realize freezing and rewarming |
| CN107951558B (en) * | 2017-11-10 | 2021-05-14 | 上海导向医疗系统有限公司 | Multifunctional gas pipeline controlled cryoablation system |
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| CN108721741A (en) * | 2018-06-08 | 2018-11-02 | 天卓睿丰医疗器械（北京）有限公司 | A kind of atomizing control system |
| CN109528292A (en) * | 2019-01-10 | 2019-03-29 | 四川捷祥医疗器械有限公司 | Bronchus therapeutic device and system |
| CN115486928B (en) * | 2022-07-14 | 2025-04-11 | 海杰亚（北京）医疗器械有限公司 | Ice ball size control method and storage medium |
| CN116421295B (en) * | 2023-06-15 | 2023-08-29 | 海杰亚（北京）医疗器械有限公司 | Cryogenic refrigeration system and control method thereof |
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