CN103961335B - Pulullan polysaccharide soft capsule and preparation method thereof - Google Patents
Pulullan polysaccharide soft capsule and preparation method thereof Download PDFInfo
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- CN103961335B CN103961335B CN201410218210.8A CN201410218210A CN103961335B CN 103961335 B CN103961335 B CN 103961335B CN 201410218210 A CN201410218210 A CN 201410218210A CN 103961335 B CN103961335 B CN 103961335B
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- pulullan polysaccharide
- soft capsule
- capsule
- water
- preparation
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- 150000004676 glycans Chemical class 0.000 title claims abstract description 32
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 32
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 32
- 239000007901 soft capsule Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000006184 cosolvent Substances 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 8
- 239000004014 plasticizer Substances 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical group OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 claims description 11
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical group [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 11
- 235000010331 calcium propionate Nutrition 0.000 claims description 11
- 239000004330 calcium propionate Substances 0.000 claims description 11
- 239000000679 carrageenan Substances 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- 239000002775 capsule Substances 0.000 abstract description 20
- 239000003814 drug Substances 0.000 abstract description 13
- 229920000159 gelatin Polymers 0.000 abstract description 9
- 235000019322 gelatine Nutrition 0.000 abstract description 9
- 239000002994 raw material Substances 0.000 abstract description 8
- 238000011049 filling Methods 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 abstract description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 239000001828 Gelatine Substances 0.000 abstract description 2
- 206010023126 Jaundice Diseases 0.000 abstract description 2
- 230000004888 barrier function Effects 0.000 abstract description 2
- 230000007062 hydrolysis Effects 0.000 abstract description 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 2
- 239000003595 mist Substances 0.000 abstract description 2
- 239000003292 glue Substances 0.000 description 19
- 238000003756 stirring Methods 0.000 description 11
- 108010010803 Gelatin Proteins 0.000 description 7
- 239000008273 gelatin Substances 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 239000000499 gel Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 235000019737 Animal fat Nutrition 0.000 description 2
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 2
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of pulullan polysaccharide soft capsule and preparation method thereof.Described pulullan polysaccharide soft capsule is made by comprising following weight percent composition: pulullan polysaccharide 20 ~ 60%, gel 0.15 ~ 2%, plasticizer 15 ~ 30%, emulsifying agent 0.02 ~ 0.8%, cosolvent 0.03 ~ 0.3%, water 22 ~ 63%.Pulullan polysaccharide soft capsule of the present invention has higher oxygen barrier and impact strength, and quality stability is good, not easily friability, and slaking index is stablized, not facile hydrolysis, and long-time placement surface does not send out mist jaundice; Raw material used is pure plant origin, can avoid the pollution that may cause because of animal proteinum completely.This capsule water content, lower than gelatine capsule, is more easily applicable to filling hygroscopic drugs and aldehyde-containing type medicine, has market prospect and practical value widely.
Description
Technical field
The present invention relates to a kind of capsule technique field, particularly relating to a kind of take pulullan polysaccharide as the pulullan polysaccharide soft capsule of primary raw material and the preparation method of this soft capsule.
Background technology
Soft capsule is in recent years at a kind of novel form capsule that the fields such as medicine, food, health product, cosmetics grow up, it is by quantitative for packed article pressure injection and is encapsulated in rubber, form seal capsule, there is the advantages such as content is accurate, uniformity good, good looking appearance.
But as the rubber of soft capsule, be all be used as major ingredient gel with gelatin at present substantially.The hard capsule water content prepared with gelatin has certain limit (12.5% ~ 17.5%), as lower than this scope, then the friability of capsule increases, be unfavorable for the filling of medicine, for easy hygroscopic drugs (some Chinese herbal medicine), the moisture of capsule is easily filled with thing and draws, and the medicine that filling is good easily splits at storage life capsule; In addition, for medicine unstable after moisture absorption, also have impact on expiration date of drug, gelatin can with Cucumber generation crosslinked action, as aldehyde, polyphenol, reducing sugar, multi-charge cation, electrolyte, cation or anionic polymer etc., thus capsule mechanical performance or biological function are changed; Gelatin not only by protease cracking and strong acid hydrolysis, also can cause degeneration because of highly basic.Therefore, during filling liquid medicine, pH should control 4.5 ~ 7.5.
The soft capsule prepared with gelatin and the medicine of capsule will have certain constant-temperature constant-humidity environment to store, and Yin Wendu is too high, the easy softening transform of capsule, and temperature is too low, the easy embrittlement of capsule.Gelatin is animal proteinum colloid, and containing certain Animal fat, in general gelatin, Animal fat content is approximately 2.2%, and easily cause pollution (foot and mouth disease, bovine spongiform encephalopathy etc.), these shortcomings constrain applying of soft capsule products.
Summary of the invention
Technical problem to be solved by this invention is to provide that a kind of disintegration rate is fast, friability is better, appearance is glittering and translucent, oxygen permeability is low, storage time is long, and all raw materials are the biological pulullan polysaccharide soft capsule prepared without any artificial synthetic ingredient, additionally provide the preparation method of this pulullan polysaccharide soft capsule simultaneously.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Pulullan polysaccharide soft capsule, makes by comprising following weight percent composition: pulullan polysaccharide 20 ~ 60%, gel 0.15 ~ 2%, plasticizer 15 ~ 30%, emulsifying agent 0.02 ~ 0.8%, cosolvent 0.03 ~ 0.3%, water 22 ~ 63%.
As preferably, described gel is carrageenan;
As preferably, described plasticizer is glycerol;
As preferably, described emulsifying agent is sophorolipid;
As preferably, described cosolvent is calcium propionate;
Present invention also offers the preparation method of above-mentioned pulullan polysaccharide soft capsule, comprise the following steps:
(1) by the water of percentage by weight 22 ~ 63%, add and can in the heating and stirring tank of evacuation, allow blender operate with the speed of 30 ~ 50 revs/min;
(2) percentage by weight is respectively pulullan polysaccharide 20 ~ 60%, gel 0.15 ~ 2%, plasticizer 15 ~ 30%, emulsifying agent 0.02 ~ 0.8%, cosolvent 0.03 ~ 0.3%, put into respectively in tank, after feeding intake, mixing speed is adjusted to 50 ~ 80 revs/min, each component be stirred to mix homogeneously and dissolve formation glue completely;
(3) temperature in tank is risen to 60 ~ 95 DEG C, stir with the speed of 30 ~ 50 revs/min, keep 0.5 ~ 3 hour;
(4) continue to stir with the speed of 30 ~ 50 revs/min, evacuation eliminates the bubble in glue simultaneously;
(5) glue mould is made strip film; And film is rested on temperature 35 ~ 75 DEG C, in the environment of humidity 20 ~ 70%, leave standstill 2 ~ 36 hours;
(6) described film is sent into soft capsule pellet press pelleting, obtained finished product.
As preferably, described gel is carrageenan; Described plasticizer is glycerol; Described emulsifying agent is sophorolipid; Described cosolvent is calcium propionate.
Owing to have employed technique scheme, pulullan polysaccharide soft capsule, makes by comprising following weight percent composition: pulullan polysaccharide 20 ~ 60%, gel 0.15 ~ 2%, plasticizer 15 ~ 30%, emulsifying agent 0.02 ~ 0.8%, cosolvent 0.03 ~ 0.3%, water 22 ~ 63%; The present invention adopts pulullan polysaccharide as material of main part, because pulullan polysaccharide molecule is regular, the change of molecular weight scope is little, product quality easily controls, and has higher oxygen barrier and impact strength, and quality stability is good, not easily friability, slaking index is stablized, not facile hydrolysis, and long-time placement surface does not send out mist jaundice; Raw material used is pure plant origin, can avoid the pollution (foot and mouth disease, bovine spongiform encephalopathy etc.) that may cause because of animal proteinum completely.This capsule can fill lipophile liquid, semisolid and plaster material, and especially all the components of this capsule is all that biological fermentation process is produced, and meets the requirements for pharmaceuticals of Arab countries.This capsule water content, lower than gelatine capsule, is more easily applicable to filling hygroscopic drugs and aldehyde-containing type medicine, has market prospect and practical value widely.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further:
embodiment 1:
First, prepare following raw material: pulullan polysaccharide 2000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 2g, calcium propionate 3g, water 6500g.
Then, prepare capsule according to the following steps: (1) adds 6300g water can in the heating and stirring tank of evacuation, to allow blender operate with the speed of 50 turns/min; (2) by pulullan polysaccharide 2000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 2g, calcium propionate 3g puts in tank respectively, after feeding intake, mixing speed is adjusted to 80 turns/min, each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 60 DEG C, keep 0.5h; (4) stir with the speed of 30 turns/min, evacuation eliminates the bubble in glue simultaneously; (5) glue mould is made strip film; (6) film is rested on 75 DEG C, in the environment of humidity 20%, leave standstill 36 hours; (7) above-mentioned obtained film is sent into soft capsule pellet press pelleting, namely obtain pulullan polysaccharide soft capsule.
embodiment 2:
First, prepare following raw material: pulullan polysaccharide 6000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 80g, calcium propionate 30g, water 2500g.
Then, prepare capsule according to the following steps: (1) adds 2200g water can in the heating and stirring tank of evacuation, to allow blender operate with the speed of 30 turns/min; (2) by pulullan polysaccharide 6000g, Wei Lan glue 200g, glycerol 1500g, sophorolipid 80g, calcium propionate 30g puts in tank respectively, after feeding intake, mixing speed is adjusted to 50 turns/min, each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 75 DEG C, keep 3h; (4) stir with the speed of 30 turns/min, evacuation eliminates the bubble in glue simultaneously; (5) glue mould is made strip film; (6) film is rested on 35 DEG C, in the environment of humidity 70%, leave standstill 36 hours; (7) above-mentioned obtained film is sent into soft capsule pellet press pelleting, namely obtain pulullan polysaccharide soft capsule.
embodiment 3:
First, prepare following raw material: pulullan polysaccharide 4000g, Wei Lan glue 15g, glycerol 3000g, sophorolipid 60g, calcium propionate 10g, water 3000g.
Then, prepare capsule according to the following steps: (1) adds 3000g water can in the heating and stirring tank of evacuation, to allow blender operate with the speed of 30 turns/min; (2) by pulullan polysaccharide 4000g, Wei Lan glue 15g, glycerol 3000g, sophorolipid 60g, calcium propionate 10g puts in tank respectively, after feeding intake, mixing speed is adjusted to 50 turns/min, each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 95 DEG C, keep 1h; (4) stir with the speed of 30 turns/min, evacuation eliminates the bubble in glue simultaneously; (5) glue mould is made strip film; (6) film is rested on 55 DEG C, in the environment of humidity 20%, leave standstill 30 hours; (7) above-mentioned obtained film is sent into soft capsule pellet press pelleting, namely obtain pulullan polysaccharide soft capsule.
embodiment 4:
First, prepare following raw material: pulullan polysaccharide 3000g, Wei Lan glue 50g, glycerol 3000g, sophorolipid 50g, calcium propionate 10g, water 4000g.
Then, prepare capsule according to the following steps: (1) adds 4000g water can in the heating and stirring tank of evacuation, to allow blender operate with the speed of 50 turns/min; (2) by pulullan polysaccharide 3000g, Wei Lan glue 50g, glycerol 3000g, sophorolipid 50g, calcium propionate 10g puts in tank respectively, after feeding intake, mixing speed is adjusted to 60 turns/min, each component is stirred to mix homogeneously and dissolves completely; (3) open heater switch, temperature in tank is risen to 60 DEG C, keep 1.5h; (4) stir with the speed of 40 turns/min, evacuation eliminates the bubble in glue simultaneously; (5) glue mould is made strip film; (6) film is rested on 65 DEG C, in the environment of humidity 40%, leave standstill 18 hours; (7) above-mentioned obtained film is sent into soft capsule pellet press pelleting, namely obtain pulullan polysaccharide soft capsule.
More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (1)
1. pulullan polysaccharide soft capsule, is characterized in that, makes: pulullan polysaccharide 20 ~ 60%, gel 0.15 ~ 2%, plasticizer 15 ~ 30%, emulsifying agent 0.02 ~ 0.8%, cosolvent 0.03 ~ 0.3%, water 22 ~ 63% by comprising following weight percent composition;
Described gel is carrageenan;
Described plasticizer is glycerol;
Described emulsifying agent is sophorolipid;
Described cosolvent is calcium propionate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410218210.8A CN103961335B (en) | 2014-05-22 | 2014-05-22 | Pulullan polysaccharide soft capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410218210.8A CN103961335B (en) | 2014-05-22 | 2014-05-22 | Pulullan polysaccharide soft capsule and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103961335A CN103961335A (en) | 2014-08-06 |
| CN103961335B true CN103961335B (en) | 2016-01-13 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105363038A (en) * | 2014-09-01 | 2016-03-02 | 天津宏顺科生物科技有限公司 | Preparation method of pulullan soft capsule |
| CN104436204A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide capsule and preparation process thereof |
| CN106723290B (en) * | 2017-03-31 | 2018-09-21 | 江苏中烟工业有限责任公司 | It is a kind of based on tobacco protein, the microcapsule preparation method of tobacco polysaccharide gel and application |
| WO2018189584A1 (en) | 2017-04-14 | 2018-10-18 | Capsugel Belgium Nv | Pullulan capsules |
| EP3610028A1 (en) | 2017-04-14 | 2020-02-19 | Capsugel Belgium NV | Process for making pullulan |
| CN109260171A (en) * | 2018-10-12 | 2019-01-25 | 江苏力凡胶囊有限公司 | A kind of preparation method of the pulullan polysaccharide capsule of stable disintegration |
| CN109568154A (en) * | 2018-12-28 | 2019-04-05 | 北京航洋健康科技有限公司 | A kind of capsule housing and the fragrant soft capsule of lock prepared therefrom and preparation method thereof |
| CN112891316A (en) * | 2021-02-01 | 2021-06-04 | 吉林万通药业有限公司 | Vitamin E soft capsule and preparation method thereof |
| CN114028357A (en) * | 2021-09-28 | 2022-02-11 | 山东弥美生物科技股份有限公司 | Pullulan soft capsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101069678A (en) * | 2007-06-15 | 2007-11-14 | 广东富味制果厂有限公司 | Soft capsule and preparing method thereof |
| CN102670563A (en) * | 2012-06-05 | 2012-09-19 | 江南大学 | Preparation method of soft capsule without gelatin |
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