CN114209330A - Baffle and neural interface system - Google Patents
Baffle and neural interface system Download PDFInfo
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- CN114209330A CN114209330A CN202111683331.6A CN202111683331A CN114209330A CN 114209330 A CN114209330 A CN 114209330A CN 202111683331 A CN202111683331 A CN 202111683331A CN 114209330 A CN114209330 A CN 114209330A
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- 108010022355 Fibroins Proteins 0.000 claims description 9
- 239000004020 conductor Substances 0.000 claims description 6
- 229910000679 solder Inorganic materials 0.000 claims description 5
- 125000006850 spacer group Chemical group 0.000 claims description 5
- 229920002749 Bacterial cellulose Polymers 0.000 claims description 4
- 239000005016 bacterial cellulose Substances 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- 229920000704 biodegradable plastic Polymers 0.000 claims description 3
- 229920000229 biodegradable polyester Polymers 0.000 claims description 3
- 239000004622 biodegradable polyester Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
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- 230000000452 restraining effect Effects 0.000 claims description 3
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- 229910052738 indium Inorganic materials 0.000 description 13
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/262—Needle electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention provides a partition plate and a neural interface system, wherein at least one micro-needle hole is formed in a partition plate body, the partition plate body is made of degradable materials, the partition plate has the functions of fixing and positioning, and is degradable, so that the human organs and tissues are not damaged.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a partition board and a neural interface system.
Background
The nerve interface provides a channel for connecting the nerve cell with an external device, and can stimulate the nerve cell to generate action potential through the external device and record the action potential generated by the nerve cell so as to realize the bidirectional communication between the nerve cell and the external device. Therefore, neural interfaces are widely used in research and treatment of various neurological diseases, such as parkinson's disease, epilepsy, depression, essential tremor, and the like.
The neural interface device is mainly divided into a set type neural electrode and a non-set type neural electrode, and compared with the non-set type neural electrode, the set type neural electrode is focused by scholars at home and abroad due to high resolution. However, when the neural interface device among the prior art is specifically used, the degree of difficulty of performing the operation is great when invasive micropin sets up, because the limitation of operation, can't realize the accurate setting of micropin and avoid target area tissue displacement phenomenon accurately.
Thus, there is a need for a better solution to the problems of the prior art.
Disclosure of Invention
In view of the above, the present invention provides a partition board and a neural interface system, which are used to solve the problems in the prior art, wherein the partition board can perform the fixing and positioning functions, and the partition board is degradable and can not cause damage to human organs and tissues.
To solve the foregoing problems, the present invention proposes the following specific embodiments: the partition plate comprises a partition plate body, wherein at least one micro-needle hole is formed in the partition plate body, and the partition plate body is made of degradable materials.
Preferably, the separator is formed by stacking at least two separator bodies.
Preferably, the degradable material comprises fibroin, bacterial cellulose, ultra-pure magnesium, biodegradable plastic or biodegradable polyester.
Preferably, the separator is used with microneedles; the micro-needle comprises at least one body electrode, wherein the body electrode passes through the corresponding micro-needle hole so as to fix and position the micro-needle.
To solve the foregoing problems, the present invention proposes the following specific embodiments: providing a neural interface system comprising a spacer and a microneedle as described herein; the micro-needle comprises at least one micro-needle assembly, the micro-needle assembly comprises a micro-needle body and an integrated circuit chip, and the integrated circuit chip is arranged at the tail part of the micro-needle body.
Preferably, the microneedle comprises: a restraining device for assembling at least two of the microneedle assemblies together.
Preferably, the both ends of little needle body afterbody are provided with the through-hole, the constraint device includes the connecting rod, the connecting rod runs through the through-hole that is located the homonymy.
Preferably, the micro needle body comprises at least one body electrode, and at least one body electrode point is arranged on the body electrode.
Preferably, the tail part of the micro needle body is provided with at least one first welding point, and each body electrode point is connected with the corresponding first welding point through a connecting wire.
Preferably, the first pads are provided with a conductive material, the integrated circuit chip is provided with at least one second pad, each second pad is provided with a conductive material, and the first pads are electrically connected with the second pads.
The invention provides a partition board and a neural interface system, wherein the partition board comprises a partition board body, at least one micro-needle hole is formed in the partition board body, and the partition board body is made of degradable materials. In this application, the baffle plays guiding orientation's effect, realizes the accurate setting of micropin, the baffle still plays fixed effect, can avoid target area tissue to take place the displacement, and the baffle degradable can not cause the damage to human organ and tissue.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings required to be used in the embodiments will be briefly described below, and it should be understood that the following drawings only illustrate some embodiments of the present invention, and therefore should not be considered as limiting the scope of the present invention. Like components are numbered similarly in the various figures.
FIG. 1 shows a schematic diagram of a neural interface system proposed by an embodiment of the present invention;
FIG. 2 is a schematic diagram of a microneedle body according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a silicon-on-chip neural interface micro-needle structure according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of the connection of the bulk electrode pads to the indium columns according to an embodiment of the present invention;
fig. 5 is a schematic diagram of a circuit structure of an indium stud-connected integrated circuit chip according to an embodiment of the present invention.
Wherein: 1. a bulk electrode; 2. a body electrode point; 3. an indium column; 4. an integrated circuit chip; 5. a partition plate; 6. a connecting wire; 7. a silicon substrate; 8. a contact electrode; 9. a poly-gate.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
Hereinafter, the terms "including", "having", and their derivatives, which may be used in various embodiments of the present invention, are only intended to indicate specific features, numbers, steps, operations, elements, components, or combinations of the foregoing, and should not be construed as first excluding the existence of, or adding to, one or more other features, numbers, steps, operations, elements, components, or combinations of the foregoing.
Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which various embodiments of the present invention belong. The terms (such as those defined in commonly used dictionaries) should be interpreted as having a meaning that is consistent with their contextual meaning in the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein in various embodiments of the present invention.
Example 1:
in this embodiment, a partition board 5 is provided, which includes a partition board 5 body, and at least one micro-needle hole is provided on the partition board 5 body, wherein the partition board 5 body is made of degradable material. The degradable material comprises fibroin, bacterial cellulose, ultra-pure magnesium, biodegradable plastic or biodegradable polyester.
In an alternative embodiment, the separator 5 comprises at least two separator 5 bodies, and the separator 5 is formed by stacking at least two separator 5 bodies. In specific use, the number of the separator 5 bodies can be adjusted according to the actual required thickness, for example, a fixing member can be arranged on the separator 5 body, at least two separator 5 bodies can be stacked together through the fixing member, the fixing member can be in a hole-column matching manner, or at least two separator 5 bodies can be stacked together in a bonding manner.
In practical use, the clapboard 5 is matched with the micro-needle for use; the micro-needle comprises at least one body electrode 1, wherein the body electrode 1 penetrates through the corresponding micro-needle hole to fix and position the micro-needle.
In this embodiment, the number of the micro pinholes may be one or multiple, specifically determined by the number of the body electrodes 1 included in the microneedles, and the distribution form of the micro pinholes may be in an array distribution or a staggered distribution, specifically determined by the distribution form of the body electrodes 1 included in the microneedles, which is not specifically limited herein.
Different from the prior art, the invention provides a partition plate 5 and a neural interface system, wherein the partition plate 5 comprises a partition plate 5 body, at least one micro-needle hole is formed in the partition plate 5 body, and the partition plate 5 body is made of degradable materials. In this application, baffle 5 plays guide positioning's effect, realizes the accurate setting of micropin, baffle 5 still plays fixed effect, can avoid target area tissue to take place the displacement, and baffle 5 degradable can not cause the damage to human organ and tissue.
Example 2:
in conjunction with example 1, this embodiment also provides a neural interface system including the spacer 5 and the microneedles according to example 1; the micro-needle comprises at least one micro-needle assembly, the micro-needle assembly comprises a micro-needle body and an integrated circuit chip 4, and the integrated circuit chip 4 is arranged at the tail part of the micro-needle body. The micro-needle body is provided with at least one body electrode 1, one side of the micro-needle body, which is far away from the needle point of the body electrode 1, is a tail part of the micro-needle body, and the tail part of the micro-needle body can be of a strip-shaped platy structure and is specifically determined according to the distribution form of the body electrode 1.
In alternative embodiments, one of the micro-needle bodies may include one body electrode 1, and may also include a plurality of body electrodes 1. When one micro needle body includes a plurality of body electrodes 1, the plurality of body electrodes 1 may be distributed in a row, and the plurality of body electrodes 1 may also be distributed in a plurality of rows.
In a possible embodiment, the microneedle may include one microneedle assembly, or may include at least two microneedle assemblies, which may be determined according to actual situations. When the microneedle may comprise at least two microneedle assemblies, the microneedle further comprises: a restraining device for assembling at least two of the microneedle assemblies together to form microneedles.
In an alternative embodiment, through holes are formed at two ends of the tail of the microneedle body, and the binding device comprises a connecting rod which penetrates through the through holes on the same side.
In another optional embodiment, the binding device includes a fixing member, the fixing member is provided with a plurality of first engaging portions, the tail portion of the microneedle body is provided with a second engaging portion, the first engaging portion and the second engaging portion engage with each other to fix at least two microneedle assemblies on the fixing member, for example, the second engaging portion may be provided in a direction away from the needle tip of the microneedle body.
Further, the micro needle body comprises at least one body electrode 1, and at least one body electrode point 2 is arranged on the body electrode 1. The tail part of the micro needle body is provided with at least one first welding point, and each body electrode point 2 is connected with the corresponding first welding point through a connecting wire 6. The first welding points are provided with conductive materials, the integrated circuit chip 4 is provided with at least one second welding point, each second welding point is provided with the conductive materials, and the first welding points are electrically connected with the second welding points.
Example 3:
as shown in fig. 1, embodiment 1 of the present invention provides a separator, including a separator body 5, where at least one micro-pinhole is disposed on the separator body 5, and the separator body 5 is made of a degradable material.
Wherein, degradable material includes fibroin or bacterial cellulose etc. in other embodiments, also can adopt other materials to make baffle body 5, guarantees baffle body 5 can degrade can.
In a practical application scenario, the separator is used in cooperation with a microneedle, the microneedle comprises at least one body electrode, and the body electrode penetrates through a corresponding micro-pinhole to fix and position the microneedle.
In an alternative embodiment, the thickness of the separator body 5 is 0.5mm to 1.5 mm; the size of the spacer body 5 is larger than that of the microneedles.
The partition body 5 comprises a middle area and an extension area, at least one micro-needle hole is distributed in the middle area of the partition body 5, the extension area is used for abutting against a supporting portion of an intracranial partition frame to arrange the partition body 5 in an skull opening through the intracranial partition frame, the extension area is an area with the width of 2 mm-3 mm extending along a certain direction in the middle area, and the aperture of the micro-needle hole is 100-200 um.
In an optional embodiment, a fibroin plate-shaped structure with a certain thickness is manufactured by adopting mould pouring to form the partition plate body 5, and then at least one micro-pinhole is punched on the partition plate body 5 in a punching mode to form the partition plate. The punching mode comprises mechanical punching, laser punching or other modes. The micro-needle holes are through holes, the micro-needle holes are quadrilateral, for example, the micro-needle holes are square, rhombic and the like, and the micro-needle holes can also be circular.
Specifically, the separator can be produced by the following steps:
(1) determining the size of the separator body 5 and the number and positions of micro-needle holes according to the manufactured micro-needles;
(2) adopting a mould to pour and manufacture a fibroin plate-shaped structure with a certain thickness to form a clapboard body 5;
(3) and marking punching positions on the separator body 5 according to the number and the positions of the micro-pinholes, and then executing punching operation to form the separator.
In other alternative embodiments, a mold with a convex column can be manufactured in advance according to the manufactured invasive nerve interface microneedle, and then a certain thickness of fibroin is poured by using the mold to form the partition plate.
In this embodiment, the baffle plays fixed and positioning action, and the baffle degradable can not cause the damage to human organ and tissue.
Example 4:
as shown in fig. 1 to 3, embodiment 2 of the present invention provides a neural interface system, including the spacer 5 and the microneedles according to the foregoing embodiment 1; the microneedle comprises: the micro-needle assembly comprises a micro-needle body and an integrated circuit chip 4, the tail part of the micro-needle body is bonded with the integrated circuit chip 4 to form the micro-needle assembly, and a plurality of groups of micro-needle assemblies form the micro-needles.
Specifically, the microneedle includes: the connecting rod, the both ends of little needle body afterbody are provided with the through-hole, the connecting rod runs through homonymy through-hole on each little needle body to with the multiunit the micropin subassembly concatenates together, in order to form the micropin.
Specifically, the micro needle body comprises at least one individual electrode 1, the individual electrode 1 is arranged on the tail part of the micro needle body, the axis of the through hole is vertical to the length direction of the individual electrode 1, the through hole is positioned at the outer side of the side-most individual electrode 1 at the corresponding side,
in this embodiment, a plurality of body electrode points 1 are formed on each body electrode 1 of the micro-needle body. The tail part of the micro needle body is provided with a plurality of first welding points, and each body electrode point 1 is connected with the corresponding first welding point through a connecting wire. Be provided with first indium post on the first solder joint, a plurality of second solder joints have on the integrated circuit chip, every be provided with second indium post on the second solder joint, first indium post and corresponding second indium post is connected, so that integrated circuit chip and corresponding little needle body afterbody is through corresponding indium post bonding connection.
Specifically, as shown in fig. 4, a plurality of individual electrode points 2 on the micro-needle body are connected to an indium column 3 (first indium column) through connection lines 6.
Specifically, as shown in fig. 5, the integrated circuit chip 4 is an integrated circuit chip silicon device, and the integrated circuit chip 4 includes a silicon substrate 7, and a contact electrode 8 and a poly-gate 9 are disposed on the silicon substrate 7.
Specifically, the silicon substrate 7 is a P-type silicon substrate.
Specifically, the indium columns 3 disposed on the integrated circuit chip 4 are electrically connected to the silicon substrate 7 through the connection lines 6.
Specifically, the connection line 6 is a metal line.
Example 3
For further explanation, embodiment 3 of the present invention further discloses a method for manufacturing a neural interface system, including the steps of:
s1, manufacturing the micro needle body by adopting a standard MEMS processing technology;
s2, processing a plurality of body electrode points on the micro needle body;
s3, respectively arranging indium columns on the micro needle body and the integrated circuit chip;
s4, bonding the microneedle body provided with the indium columns and the integrated circuit chip to form a microneedle assembly;
and S5, respectively processing two through holes at two ends of the micro needle bodies for penetrating the connecting rods to assemble the micro needles in a matrix structure.
S6, manufacturing a fibroin plate-shaped structure with a certain thickness by adopting mould pouring, and punching at least one micro-pinhole on the fibroin plate-shaped structure in a mechanical punching mode to form the partition plate.
And S7, enabling the body electrodes on the micro-needles to penetrate through the through holes on the partition board in a one-to-one correspondence mode, and thus obtaining the neural interface system.
(1) The micro needle comprises a micro needle body, wherein the micro needle body is provided with at least one body electrode regardless of whether an integrated circuit chip is arranged or not;
(2) the micro needle comprises a micro needle body, wherein the micro needle body is provided with at least three body electrodes, and at least two body electrodes are distributed in one row or multiple rows regardless of whether an integrated circuit chip is arranged or not;
(3) the microneedle comprises a microneedle assembly, the microneedle assembly comprises the microneedle body and the integrated circuit chip, and the integrated circuit chip is bonded with the microneedle body to form the microneedle assembly;
(4) the microneedle comprises at least two microneedle assemblies, the at least two microneedle assemblies are assembled together, and the at least two microneedle assemblies are distributed in one or more rows.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention.
Claims (10)
1. The partition board is characterized by comprising a partition board body, wherein at least one micro-needle hole is formed in the partition board body, and the partition board body is made of degradable materials.
2. The separator of claim 1 wherein said separator is formed from a stack of at least two of said separator bodies.
3. The separator of claim 1, wherein said degradable material comprises fibroin, bacterial cellulose, ultra pure magnesium, a biodegradable plastic, or a biodegradable polyester.
4. The separator of claim 1, wherein the separator is used with microneedles; the micro-needle comprises at least one body electrode, wherein the body electrode passes through the corresponding micro-needle hole so as to fix and position the micro-needle.
5. A neural interface system, comprising the spacer of any one of claims 1 to 4 and a microneedle; the micro-needle comprises at least one micro-needle assembly, the micro-needle assembly comprises a micro-needle body and an integrated circuit chip, and the integrated circuit chip is arranged at the tail part of the micro-needle body.
6. The neural interface system of claim 5, wherein the microneedles comprise: a restraining device for assembling at least two of the microneedle assemblies together.
7. The neural interface system of claim 6, wherein the rear portion of the micro-needle body is provided at both ends thereof with through holes, and the binding means includes a connecting rod penetrating through the through holes at the same side.
8. The neural interface system of claim 5, wherein the microneedle comprises at least one body electrode having at least one body electrode point disposed thereon.
9. The neural interface system of claim 5, wherein the tail of the micro-needle body has at least one first solder joint thereon, and each of the body electrode points is connected to a corresponding first solder joint by a connecting wire.
10. The neural interface system of claim 9, wherein the first pad has an electrically conductive material disposed thereon, the integrated circuit chip having at least one second pad thereon, each of the second pads having an electrically conductive material disposed thereon, the first pad and the second pad being electrically connected.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111683331.6A CN114209330A (en) | 2021-12-31 | 2021-12-31 | Baffle and neural interface system |
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| CN202111683331.6A CN114209330A (en) | 2021-12-31 | 2021-12-31 | Baffle and neural interface system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115500833A (en) * | 2022-08-24 | 2022-12-23 | 武汉衷华脑机融合科技发展有限公司 | A positioning partition and surface array microneedle structure |
| CN116898449A (en) * | 2023-06-21 | 2023-10-20 | 中国科学院上海微系统与信息技术研究所 | Flexible electrode and preparation method thereof |
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