CN114344545A - Bacteriostatic hemostatic dressing and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of medical devices, and discloses a bacteriostatic and hemostatic dressing and a preparation method thereof. The main technical scheme is as follows: the antibacterial and hemostatic dressing includes two layers, one layer is an antibacterial activated carbon fiber layer, and the other layer is a sea octopus degradable polymer composite activated carbon fiber layer; the antibacterial activated carbon fiber layer contains polyhexamethylene biguanide , silver ions or nano-silver, organosilicon quaternary ammonium salt bacteriostatic components; sea octopus ultrafine powder and degradable polymer are first added into a solvent to make a suspension, sprayed on activated carbon fibers by atomization, and then vacuum-dried to obtain Sea octopus degradable polymer composite activated carbon fiber layer; two layers are assembled by rolling through the adhesion properties of fibers. Compared with the prior art, the dressing has both bacteriostatic and hemostasis functions. The hemostatic component is on the second layer and does not directly contact the skin wound, which can avoid the problem of entering the body and causing thrombosis.

Description

A kind of antibacterial hemostatic dressing and preparation method thereof

technical field

The invention relates to the technical field of medical manufacturing, in particular to a bacteriostatic and hemostatic activated carbon fiber dressing and a preparation method thereof.

Background technique

With the development of social economy, people's way of life has undergone profound changes. In particular, with the aging of the population and the acceleration of urbanization, the prevalence of cardiovascular disease risk factors in China is on the rise, leading to a continuous increase in the number of people with cardiovascular disease. Due to the increase of cardiovascular diseases, more and more people are undergoing stent surgery. However, after stent surgery, the part of the blood vessel where the stent is implanted is very prone to thrombosis without the protection of effective antiplatelet drugs. The consequences are the same as After another myocardial infarction, it is necessary to take anticoagulant drugs for a long time after the operation. Patients who take anticoagulant drugs for a long time lack coagulation substances in their bodies. Once they are injured, they will bleed continuously and need to stop the bleeding quickly. Generally, the hemostatic components are ground into powder and applied directly to the wound surface, which is difficult to remove. Moreover, for people with cardiovascular and cerebrovascular diseases, the hemostatic components cannot directly contact the wound, because once the hemostatic components enter the body, there is a risk of thrombosis.

SUMMARY OF THE INVENTION

The present invention aims to provide a safe antibacterial and hemostatic activated carbon fiber dressing and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology. The activated carbon fiber dressing has the functions of absorbing tissue exudate, bacteriostasis and safe hemostasis.

To achieve the above object, the present invention adopts the following technical solutions:

An antibacterial and hemostatic dressing is composed of a bacteriostatic activated carbon fiber layer and a sea clam degradable polymer composite activated carbon fiber layer, the thickness of the bacteriostatic activated carbon fiber layer is 0.2-1 mm; the thickness of the sea clam degradable polymer composite activated carbon fiber layer 1 to 5mm.

Further, the octopus degradable polymer composite activated carbon fiber layer uses activated carbon fiber as a skeleton material, and the octopus particles and the degradable polymer are filled in the skeleton.

A method for preparing a bacteriostatic hemostatic dressing. After washing and drying activated carbon fibers, it is divided into two layers, one layer is immersed in bacteriostatic components and heat-treated, then taken out and dried to a constant weight, as the bacteriostatic activated carbon fiber layer, and the other layer is used for To prepare the degradable polymer composite activated carbon fiber layer of octopus, the octopus is washed to remove surface impurities, and then crushed and ground; the degradable polymer is dissolved in a solvent, and then the octopus particles are added, and the octopus is stirred evenly to form a suspension. liquid; the suspension was atomized into small droplets and sprayed on the activated carbon fiber by ultrasonic, and vacuum-dried after taking it out to obtain the sea cricket degradable polymer composite activated carbon fiber layer; finally, the antibacterial activated carbon fiber layer and sea cricket can be obtained The degraded polymer composite activated carbon fiber layers are stacked and assembled along the direction of the fibers.

Further, the antibacterial component is any one of polyhexamethylene biguanide, silver ion, nano-silver, and organosilicon quaternary ammonium salt.

Further, the condition of the heat treatment is to heat to a constant temperature of 40-50°C for 1-2 hours. When the antibacterial component is silver ions or nano-silver, after the heat treatment, the surface moisture is taken out to control the dry surface, and the temperature is 300°C in a nitrogen atmosphere. After heat treatment for 1 hour, the silver-loaded activated carbon fiber was prepared as a bacteriostatic activated carbon fiber layer.

Further, the octopus particles are crushed and ground to a particle size of less than 10 μm.

Further, the degradable polymer can be selected from any one or two of the following copolymerization materials: polylactide, polyglycolide, polyε-caprolactone, and polytrimethylene carbonate.

Further, the solvent is one or both of tetrahydrofuran, acetone, ethyl acetate, dichloromethane and chloroform.

Further, the mass ratio of the sea octopus particles, the degradable polymer and the solvent is 1:0.1-2:50-500.

Further, the condition of the vacuum drying is vacuum drying at 40° C. for 6 hours.

Compared with the prior art, the beneficial effects of the present invention are:

The present invention adopts activated carbon fiber as the matrix material of the dressing, utilizes its rich microporous structure to absorb bacteriostatic components, has better bacteriostatic effect and can absorb tissue exudate at the same time. Sea octopus is a commonly used marine traditional Chinese medicine. It contains calcium carbonate, protein peptides, octopus polysaccharides, chitin/chitosan and other active ingredients. In the treatment and repair of wounds, it can also degrade the composite activity of polymers. The dressing has both bacteriostatic and hemostatic effects. The hemostatic component is on the second layer, and the carbon fiber layer fixes the hemostatic octopus on the activated carbon fiber, and does not directly contact the wound, so as to prevent the hemostatic component from entering the blood and cause thrombosis. adhered to the wound.

Description of drawings

Fig. 1 is the structural representation of the present invention;

Figure 2 is a schematic diagram of the structure of the sea octopus degradable polymer composite activated carbon fiber layer.

In the figure: 1, antibacterial activated carbon fiber layer; 2, sea octopus degradable polymer composite activated carbon fiber layer; 21, activated carbon fiber layer; 22, sea octopus particles; 23, degradable polymer.

Detailed ways

The technical solutions of the present invention will be described in further detail below with reference to the embodiments. These descriptions merely illustrate the features and advantages of the present invention, but do not limit the scope of protection of the present invention. Unless otherwise specified, the experimental methods used in the present invention are all conventional methods, and the experimental equipment, materials, reagents, etc. used can be obtained from commercial sources.

Example 1

After washing and drying the activated carbon fiber, it is divided into two layers. One layer was soaked in a 0.5% polyhexamethylene biguanide solution, heated to a constant temperature of 50° C. for 2 hours, taken out and dried to a constant weight, and used as the antibacterial activated carbon fiber layer 1 . The other layer is used to prepare the octopus degradable polymer composite activated carbon fiber layer 2 . Wash the octopus to remove surface impurities, then crush and grind it to a particle size of less than 10 μm; take 0.1 g of polyglycolide and dissolve it in 50 g of dichloroethane, add 0.5 g of octopus microparticles, stir evenly, and make a suspension The suspension was atomized into small droplets and sprayed on the activated carbon fiber by ultrasonic. After taking it out, it was vacuum-dried at 40 °C for 6 hours to obtain the sea cricket degradable polymer composite activated carbon fiber layer 2; The antibacterial activated carbon fiber layer 1 of methylene biguanide and the degradable polymer composite activated carbon fiber layer 2 of octopus are overlapped along the direction of the fibers and rolled together with a small roller to obtain a bacteriostatic hemostatic dressing, which is antibacterial when used. The activated carbon fiber layer 1 is close to the wound.

Example 2

After washing and drying the activated carbon fiber, it is divided into two layers. One layer was immersed in a 0.2mol/L silver nitrate solution and heated to a constant temperature of 50 °C for 2 hours. After removing the surface moisture to control drying, heat treatment at 300 °C for 1 hour in a nitrogen atmosphere to obtain silver-loaded activated carbon fibers, which were used as antibacterial agents. Activated carbon fiber layer 1. The other layer is used to prepare the sea octopus degradable polymer composite activated carbon fiber layer 2. The sea octopus is washed to remove surface impurities, and then crushed and ground to a particle size of less than 10 μm; 0.3 g of polyε-caprolactone is dissolved in 50 g Tetrahydrofuran, then add 0.5 g of sea octopus particles, stir evenly to prepare a suspension; use ultrasonic to atomize the suspension into small droplets and spray them on the activated carbon fiber, take out and vacuum dry at 40 ° C for 6 hours, that is, to prepare seaweed The octopus degradable polymer composite activated carbon fiber layer 2; finally, the silver-loaded antibacterial activated carbon fiber layer 1 and the octopus degradable polymer composite activated carbon fiber layer 2 are overlapped and rolled together along the direction of the fibers, that is, to obtain Antibacterial hemostatic dressing.

Example 3

After washing and drying the activated carbon fiber, it is divided into two layers. One layer is immersed in a 2% organosilicon quaternary ammonium salt solution, heated to a constant temperature of 40° C. for 1 hour, taken out and dried to a constant weight, thereby obtaining an antibacterial activated carbon fiber layer 1. The other layer is used to prepare the sea octopus degradable polymer composite activated carbon fiber layer 2. The sea octopus is washed to remove surface impurities, and then crushed and ground to a particle size of less than 10 μm; 0.5 g of polytrimethylene carbonate is dissolved in 50 g Trichloromethane, then add 0.5g of sea octopus particles, stir evenly, and make a suspension; immerse the activated carbon fiber in the suspension repeatedly for 10 times, take it out and vacuum dry at 40 ° C for 6 hours, that is, the sea octopus can be obtained. Degradable polymer composite activated carbon fiber layer 2; finally, the antibacterial activated carbon fiber layer 1 loaded with organosilicon quaternary ammonium salt and the octopus degradable polymer composite activated carbon fiber layer are overlapped and rolled together along the direction of the fibers, that is, Antibacterial hemostatic dressing.

The embodiments of the present invention are not limited to those described in the above-mentioned embodiments, without departing from the spirit and scope of the present invention, those of ordinary skill in the art can make various changes, modifications, and changes to the present invention in form and detail. Substitutions and modifications are considered to fall within the scope of the present invention.

Claims (10)

1. The bacteriostatic hemostatic dressing is characterized by comprising a bacteriostatic activated carbon fiber layer (1) and a cuttlebone degradable polymer composite activated carbon fiber layer (2), wherein the thickness of the bacteriostatic activated carbon fiber layer (1) is 0.2-1 mm; the thickness of the cuttlebone degradable polymer composite activated carbon fiber layer (2) is 1-5 mm.

2. The bacteriostatic hemostatic dressing according to claim 1, wherein the cuttlebone degradable polymer composite activated carbon fiber layer (2) takes activated carbon fiber as a framework material, and cuttlebone particles (22) and degradable polymer (23) are filled in the framework.

3. A preparation method of a bacteriostatic hemostatic dressing is characterized in that activated carbon fiber is washed and dried and then divided into two layers, one layer is soaked in bacteriostatic components and heated, then taken out and dried to constant weight to be used as a bacteriostatic activated carbon fiber layer (1), the other layer is used for preparing a cuttlebone degradable polymer composite activated carbon fiber layer (2), the cuttlebone is washed to remove surface impurities, and then is crushed and ground; dissolving the degradable polymer (23) in a solvent, adding the cuttlebone particles (22), and uniformly stirring to prepare a suspension; atomizing the suspension into small drops by adopting ultrasound, spraying the small drops on the activated carbon fiber, taking out the activated carbon fiber, and then drying the activated carbon fiber in vacuum to obtain the cuttlebone degradable polymer composite activated carbon fiber layer (2); and finally, overlapping, rolling and assembling the bacteriostatic activated carbon fiber layer (1) and the cuttlebone degradable polymer composite activated carbon fiber layer (2) along the fiber direction.

4. The preparation method of the bacteriostatic hemostatic dressing according to claim 3, wherein the bacteriostatic component is any one of polyhexamethylene biguanide, silver ions, nano silver and organosilicon quaternary ammonium salt.

5. The preparation method of the bacteriostatic hemostatic dressing according to claim 3, characterized in that the heating treatment condition is heating to 40-50 ℃ and keeping the temperature for 1-2 hours, when the bacteriostatic component is silver ion or nano silver, taking out after the heating treatment to control the surface moisture, and performing heat treatment at 300 ℃ in nitrogen atmosphere for 1 hour to obtain the silver-loaded activated carbon fiber as the bacteriostatic activated carbon fiber layer (1).

6. The preparation method of the bacteriostatic hemostatic dressing according to claim 3, characterized in that the cuttlebone particles (22) are crushed and ground to a particle size below 10 μm.

7. A method for preparing a bacteriostatic hemostatic dressing according to claim 3, wherein the degradable polymer (23) is selected from any one or two of the following copolymer materials: polylactide, polyglycolide, poly-epsilon-caprolactone, polytrimethylene carbonate.

8. The method for preparing a bacteriostatic hemostatic dressing according to claim 3, wherein the solvent is one or two of tetrahydrofuran, acetone, ethyl acetate, dichloromethane and chloroform.

9. The preparation method of the bacteriostatic hemostatic dressing according to claim 3, wherein the mass ratio of the cuttlebone particles (22), the degradable polymer (23) and the solvent is 1: 0.1-2: 50 to 500.

10. The preparation method of the bacteriostatic hemostatic dressing according to claim 3, wherein the vacuum drying condition is vacuum drying at 40 ℃ for 6 hours.

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