CN114403333A - Effervescent tablet for preventing heatstroke and resisting fatigue and preparation method thereof - Google Patents

Abstract

The invention discloses an effervescent tablet for preventing heatstroke and fatigue, comprising astragalus extract, Rhodiola rosea extract, honeysuckle extract powder, Schisandra chinensis extract powder, glutamine, arginine, aspartic acid, bovine Sulfonic acid, vitamin B1, vitamin B2, vitamin B6, vitamin C, niacinamide, inositol, sodium chloride, potassium chloride, acidic foaming agent, alkaline foaming agent, filler, binder, lubricant, Flavoring agent; the effervescent tablet also has the functions of preventing heatstroke and fatigue, and selects raw materials that can prevent heatstroke and relieve physical fatigue from a variety of traditional Chinese medicine ingredients, amino acids, vitamins and electrolytes. Fatigue and electrolyte imbalance caused by life, targeted and rapid replenishment of energy and electrolytes, thus effectively preventing heatstroke and relieving fatigue.

Description

Effervescent tablet for preventing heatstroke and fatigue and preparation method thereof

technical field

The invention relates to a health drink, in particular to an effervescent tablet for preventing heatstroke and fatigue and a preparation method thereof.

Background technique

Effervescent tablet is a new type of solid preparation. Effervescent tablet is a tablet containing effervescent disintegrant. The two substances in effervescent disintegrant are not ionized and cannot react, but when the effervescent tablet is put into water. After that, the two substances undergo an acid-base reaction to generate a large number of air bubbles (carbon dioxide), which makes the tablet disintegrate rapidly. The carbon dioxide generated when the tablet disintegrates is partially dissolved in the drinking water, so that the drinking water has a soda-like beauty in the mouth. Effervescent tablets have the advantages of rapid disintegration, convenient administration, rapid onset of action, high bioavailability, and improved clinical efficacy. However, the existing effervescent tablet has a single function and is not strong in function, and especially cannot have both the functions of preventing heat stroke and anti-fatigue at the same time.

SUMMARY OF THE INVENTION

In view of this, the purpose of the present invention is to provide an effervescent tablet for preventing heatstroke and fatigue and a preparation method thereof, and simultaneously having the functions of preventing heatstroke and fatigue.

In the effervescent tablet for preventing heatstroke and fatigue of the present invention, the raw material of the effervescent tablet comprises the following components by weight: 1-5 parts of Astragalus extract, 1-5 parts of Rhodiola rosea extract, 1-5 parts of honeysuckle extract powder 5 parts, Schisandra chinensis extract powder 1-5 parts, glutamine 1-5 parts, arginine 1-5 parts, aspartic acid 1-5 parts, taurine 1-5 parts, vitamin B1 0.01-0.1 part, vitamin B2 0.01-0.1 part, vitamin B6 0.01-0.1 part, vitamin C 0.5-2 part, niacinamide 0.1-2 part, inositol 0.5-2 part, sodium chloride 0.5-10 part, potassium chloride 0.1- 5 parts, 10-30 parts of acidic foaming agent, 10-30 parts of alkaline foaming agent, 20-60 parts of filler, 1-5 parts of binder, 2-10 parts of lubricant, 2-10 parts of flavoring agent share;

Further, the raw material of the effervescent tablet comprises the following components by weight: 3 parts of Astragalus extract, 3 parts of Rhodiola rosea extract, 3 parts of honeysuckle extract powder, 3 parts of Schisandra chinensis extract powder, 3 parts of glutamine, 3 parts of arginine, 3 parts of aspartic acid, 3 parts of taurine, 0.05 parts of vitamin B1, 0.05 parts of vitamin B2, 0.05 parts of vitamin B6, 1.2 parts of vitamin C, 0.6 parts of niacinamide, 1.2 parts of inositol, chlorine 5 parts of sodium chloride, 2.5 parts of potassium chloride, 20 parts of acidic foaming agent, 20 parts of alkaline foaming agent, 40 parts of filler, 3 parts of binder, 6 parts of lubricant, 6 parts of flavoring agent;

Further, the acidic foaming agent is one or more mixtures of citric acid, tartaric acid and malic acid;

Further, the alkaline foaming agent is one or both of sodium carbonate and sodium bicarbonate;

Further, the filler is one or more mixtures of glucose, fructose, sucrose, lactose, acesulfame potassium, and aspartame;

Further, the adhesive is one or both of polyvinylpyrrolidone-K30 and dehydrated alcohol; further, the lubricant is one of magnesium stearate, silicon dioxide, and polyethylene glycol 6000 Or a mixture of two or more, and the flavoring agent is one or more mixtures of artificial flavor, sweet orange flavor, strawberry flavor, peach flavor, and kiwi flavor.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present invention comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity Mix the foaming agent and filler evenly, then add the binder to granulate, sieve and dry at 60-70°C for 1-2 hours, then sieve to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet preparation;

Further, in step b, the honeysuckle extract powder is prepared in the following manner: the dried honeysuckle is pulverized, sieved, and then continuously refluxed and extracted with 95% (V/V) ethanol, and the extract is filtered. Concentrating under reduced pressure to constant weight to obtain honeysuckle extract, then mixing honeysuckle extract with auxiliary materials, and spray-drying to obtain honeysuckle extract powder;

Further, in step b, the Schisandra chinensis extract powder is prepared in the following manner: the Schisandra chinensis is dried and then pulverized and sieved, and then continuously refluxed and extracted with 95% (V/V) ethanol, and the extract is filtered and reduced in size. Press and concentrate to constant weight to obtain Schisandra chinensis extract, then mix Schisandra chinensis extract with auxiliary materials, spray-dry to obtain Schisandra chinensis extract powder.

Beneficial effects of the present invention: the effervescent tablet for preventing heat stroke and anti-fatigue of the present invention and the preparation method thereof, the effervescent tablet has the functions of preventing heat stroke and anti-fatigue at the same time, and is selected from a variety of traditional Chinese medicine ingredients, amino acids, vitamins and electrolytes. The raw materials for preventing heat stroke and relieving physical fatigue are scientifically proportioned, and for the fatigue and electrolyte imbalance caused by work and life in high temperature weather, it can quickly replenish energy and electrolytes in a targeted manner, so as to effectively prevent heat stroke and relieve fatigue. In addition, combined with the technical means of pharmaceutical preparations, the preparation processes of acidic granulation and alkaline granulation are carried out respectively, which have the characteristics of easy storage, good stability, good solubility, and gas production during the dissolution process increases interest.

Astragalus extract contains the active bioactive components of Astragalus, Astragalus polysaccharide and Astragaloside IV. Among them, astragaloside IV is known as "super astragalus polysaccharide", its efficacy is more than 2 times that of conventional astragalus polysaccharide, and its antiviral effect is 30 times that of astragalus polysaccharide. Astragalus extract has a prominent role in enhancing the body's immunity and improving the immune defense function, mainly by promoting the activation of immune cells to release endogenous factors to defend against viruses. Astragalus extract has a significant effect on regulating the metabolic process of nutrients, and at the same time promotes the growth of bifidobacteria and lactic acid bacteria, to a certain extent, reduces and eliminates the impact of thermal environment on the physiological function of the body's gastrointestinal tract, and plays a role in anti-stress and nutritional health care. effect. In addition, astragalus extract has the functions of improving heart and lung function, protecting liver and anti-inflammatory.

Rhodiola rosea extract contains the active ingredient of Rhodiola rosea, salidroside. Its preparation has been used in sports medicine, aerospace medicine and the health protection of workers under various special environmental conditions. Rhodiola has adaptability and bidirectional regulation, which can improve the body's adaptability in hypoxic and thermal environments, protect cardiovascular function, and shorten the recovery time of muscle fatigue.

Honeysuckle extract powder, honeysuckle has been known as a good medicine for clearing away heat and detoxification since ancient times. It is sweet and fragrant in nature, sweet and cold and clears heat without hurting the stomach. It can not only disperse wind-heat, but also be good at clearing and detoxifying blood, and is used for various febrile diseases. Compatible with Astragalus, it can benefit qi, detoxify and activate blood.

Schisandra chinensis extract powder, Schisandra chinensis is acidic, has the effect of promoting body fluid and quenching thirst, and has a therapeutic effect on spontaneous perspiration and night sweat. Sun Simiao, the king of medicine in the Tang Dynasty, wrote in "Qian Jin Fang": "Frequently eat Schisandra chinensis in May to nourish the five internal organs. Decoction of Huangbo decoction makes people feel refreshed, and the strength of the muscles in both legs gushes out.

Glutamine is the most abundant free amino acid in muscle, accounting for about 60% of the total amount of free amino acids in the human body. It provides the body with a necessary nitrogen source and promotes protein synthesis in muscle cells; through cell expansion, it promotes the growth and development of muscle cells. differentiation. During exercise, the body's acid metabolites increase to acidify body fluids. Glutamine has the potential to generate bases, thus reducing the reduction in exercise capacity or fatigue caused by acidic substances to a certain extent. Therefore, under the state of high-intensity exercise and labor, the body's demand for glutamine increases, so that its own synthesis cannot meet the needs. Both animal and human experimental studies have revealed that glutamine supplementation can increase the body's strength and improve endurance. Supplementing glutamine can improve the body's antioxidant capacity by maintaining and increasing the reserve of glutathione in tissue cells, stabilize the cell membrane and protein structure, protect the functions of important organs such as the liver, lungs, intestines and immune cells, maintain Normal function of the kidneys, pancreas, gallbladder and liver.

Aspartic acid can be used as a carrier of K+ and Mg2+ ions to transport electrolytes to the myocardium, thereby improving myocardial contractile function, reducing oxygen consumption and protecting myocardium. It participates in the cycle of ornithine, promotes the production of urea from ammonia and carbon dioxide, reduces the amount of nitrogen and carbon dioxide in the blood, enhances liver function, and relieves fatigue. Aspartic acid is also a good nutritional supplement and can be used as a fatigue recovery agent in combination with a variety of amino acids.

Taurine can reduce the lipid peroxidation caused by exercise, promote the increase of the body's antioxidant enzyme activity after exercise, and protect the function of cells from the decline caused by exercise, thereby delaying the occurrence of exercise-induced fatigue. Taurine is a sulfur-containing amino acid in animals, but it is not a component of protein. It is widely distributed in various organs and tissues of humans and animals in the form of free amino acids, especially free taurine in the heart accounts for the total amount of free amino acids. as much as 50%. Studies have shown that taurine can promote the secretion of pituitary hormones, activate pancreatic function, improve the state of the body's endocrine system and enhance the body's immunity and anti-fatigue effect.

Water-soluble vitamins B1, B2, B6, nicotinamide and vitamin C are widely involved in various physiological processes in the form of coenzymes or prosthetic groups. Animals and some microorganisms cannot synthesize them, so they must be obtained from the outside world. Although the body's demand for vitamins is not high, it is essential. Vitamin B1 is the coenzyme of decarboxylase and dehydrogenase in sugar metabolism, which mainly maintains the normal metabolism of sugar, increases appetite, and maintains normal nerve activity. When the intake of vitamin B1 is insufficient, the mild cases are manifested as muscle weakness, mental indifference and loss of appetite, and the severe cases suffer from beriberi. Vitamin B2 participates in redox reactions and energy generation in the body, and also participates in the body's antioxidant defense system to improve the body's ability to adapt to environmental stress. Deficiency of vitamin B2 can lead to disorder of substance metabolism and affect iron absorption, prone to secondary iron-deficiency anemia, and also affect the metabolism of vitamin B6 and niacin. Vitamin B6 is a coenzyme of many enzyme systems in the body, and is involved in amino acid decarboxylation, transamination, synthesis of tryptophan, metabolism of sulfur-containing amino acids, formation of aminolevulinic acid, and metabolism of unsaturated fatty acids. Nicotinamide is a component of Coenzyme I and Coenzyme II and serves as a coenzyme for many dehydrogenases. Vitamin C, also known as ascorbic acid, is involved in the hydroxylation reaction and can be used as both a hydrogen donor and a hydrogen acceptor, playing an important role in the redox process in the body, and is an important auxiliary drug for the treatment of anemia.

Glucose and fructose are both bulking and energy supplements. Glucose is the energy source and metabolic intermediate product of living cells, and is the main energy supply material. Fructose has a fruity aroma, high sweetness and is not easy to cause dental caries. Studies have shown that if you consume an equal amount of mixed fructose and glucose, the oxidation rate is 21% higher than that of 100 grams of glucose alone. Because fructose and glucose have different oxidation pathways and are less competitive with each other, consuming fructose during exercise is also beneficial.

As electrolytes, sodium chloride and potassium chloride participate in many important functions and metabolic activities in the body, and play a very important role in the maintenance of normal life activities. In a normal human body, sodium ions account for 92% of the total amount of cations in extracellular fluid, and potassium ions account for about 98% of the total amount of cations in intracellular fluid. After a lot of sweating, the imbalance of sodium and potassium ions can cause corresponding obstacles to various organ systems in the body, especially the physiological functions of the cardiovascular system and the nervous system and the body's material metabolism.

Detailed ways

For better understanding of the present invention, the following examples are further descriptions of the present invention, but the content of the present invention is not limited to the following examples.

In the examples, the experimental methods used are conventional methods unless otherwise specified, and the materials, reagents, etc. used can be obtained from commercial sources unless otherwise specified.

Example 1

In the effervescent tablet for preventing heatstroke and fatigue in this embodiment, the raw material for the effervescent tablet includes the following components by weight: 1 part of Astragalus root extract, 1 part of Rhodiola rosea extract, 1 part of honeysuckle extract powder, 1 part of Schisandra chinensis extract 1 part of cream powder, 1 part of glutamine, 1 part of arginine, 1 part of aspartic acid, 1 part of taurine, 0.01 part of vitamin B1, 0.01 part of vitamin B2, 0.01 part of vitamin B6, 0.5 part of vitamin C, 0.1 part of niacinamide, 0.5 part of inositol, 0.5 part of sodium chloride, 0.1 part of potassium chloride, 10 parts of acidic foaming agent, 10 parts of alkaline foaming agent, 20 parts of filler, 1 part of binder, lubricant 2 parts, 2 parts of flavoring agent.

In this embodiment, the acidic foaming agent is citric acid. In this embodiment, citric acid is replaced by one of tartaric acid and malic acid, or a mixture of citric acid and tartaric acid and malic acid according to the same weight portion, All qualified products.

In this embodiment, the alkaline foaming agent is sodium carbonate and sodium bicarbonate.

In this embodiment, the filler is glucose. In this embodiment, glucose is replaced by one of fructose, sucrose, lactose, acesulfame potassium, and aspartame, or glucose and fructose are replaced by equal parts by weight. , sucrose, lactose, acesulfame potassium, aspartame mixture, are qualified products.

In this embodiment, the adhesive is polyvinylpyrrolidone-K30 and absolute ethanol.

In this embodiment, the lubricant is magnesium stearate. In this embodiment, magnesium stearate is replaced by one of silicon dioxide, polyethylene glycol 6000, or stearin according to the same weight portion. The mixture of magnesium acid, silicon dioxide and polyethylene glycol 6000 is qualified product.

In this embodiment, the flavoring agent is an artificial flavor. In this embodiment, the artificial flavor is replaced with one of sweet orange flavor, strawberry flavor, peach flavor, and kiwi flavor according to the same weight, or an artificial flavor. The mixture of flavor and sweet orange flavor, strawberry flavor, peach flavor and kiwi flavor are all qualified products.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present embodiment comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity The foaming agent and the filler are mixed evenly, then the binder is added to granulate, sieved and dried at 60°C for 1 hour, and then sieved to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation.

Embodiment 2

In the effervescent tablet for preventing heat stroke and anti-fatigue in this embodiment, the raw material for the effervescent tablet includes the following components by weight: 5 parts of Astragalus extract, 5 parts of Rhodiola rosea extract, 5 parts of honeysuckle extract powder, 5 parts of Schisandra chinensis extract 5 parts of cream powder, 5 parts of glutamine, 5 parts of arginine, 5 parts of aspartic acid, 5 parts of taurine, 0.1 part of vitamin B1, 0.1 part of vitamin B2, 0.1 part of vitamin B6, 2 parts of vitamin C, 2 parts of niacinamide, 2 parts of inositol, 10 parts of sodium chloride, 5 parts of potassium chloride, 30 parts of acidic foaming agent, 30 parts of alkaline foaming agent, 60 parts of filler, 5 parts of binder, lubricant 10 copies, 10 flavors.

In this embodiment, the acidic foaming agent is tartaric acid. In this embodiment, tartaric acid is replaced by one of citric acid and malic acid, or a mixture of tartaric acid and citric acid and malic acid, according to the same weight. Qualified products.

In this embodiment, the alkaline foaming agent is sodium carbonate.

In this embodiment, the filler is fructose. In this embodiment, fructose is replaced by one of glucose, sucrose, lactose, acesulfame potassium, and aspartame, or fructose and glucose are replaced by equal parts by weight. , sucrose, lactose, acesulfame potassium, aspartame mixture, are qualified products.

In this embodiment, the binder is absolute ethanol.

In this embodiment, the lubricant is magnesium stearate. In this embodiment, magnesium stearate is replaced by one of silicon dioxide, polyethylene glycol 6000, or stearin according to the same weight portion. The mixture of magnesium acid, silicon dioxide and polyethylene glycol 6000 is qualified product.

In this embodiment, the flavoring agent is sweet orange essence. In this embodiment, the sweet orange essence is replaced with one of artificial essence, strawberry essence, peach essence, and kiwi essence according to the same weight, or is replaced with The mixture of sweet orange flavor and artificial flavor, strawberry flavor, peach flavor and kiwi flavor are all qualified products.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present embodiment comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity The foaming agent and the filler are mixed evenly, then the binder is added to granulate, sieved and dried at 70°C for 2 hours, and then sieved to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation.

Embodiment 3

In the effervescent tablet for preventing heatstroke and fatigue in the present embodiment, the raw material for the effervescent tablet includes the following components by weight: 1 part of Astragalus root extract, 5 parts of Rhodiola rosea extract, 1 part of honeysuckle extract powder, Schisandra chinensis extract 5 parts of cream powder, 1 part of glutamine, 5 parts of arginine, 1 part of aspartic acid, 5 parts of taurine, 0.01 part of vitamin B1, 0.1 part of vitamin B2, 0.01 part of vitamin B6, 2 parts of vitamin C, 0.1 part of niacinamide, 2 parts of inositol, 0.5 parts of sodium chloride, 5 parts of potassium chloride, 10 parts of acidic foaming agent, 30 parts of alkaline foaming agent, 20 parts of filler, 5 parts of binder, lubricant 2 copies, 10 flavors.

In this embodiment, the acidic foaming agent is malic acid. In this embodiment, malic acid is replaced by one of tartaric acid and citric acid, or a mixture of malic acid, tartaric acid and citric acid according to the same weight portion, All qualified products.

In this embodiment, the alkaline foaming agent is sodium bicarbonate.

In this embodiment, the filler is sucrose. In this embodiment, sucrose is replaced by one of fructose, glucose, lactose, acesulfame potassium, and aspartame, or sucrose and fructose are replaced by equal parts by weight. , glucose, lactose, acesulfame potassium, aspartame mixture, are qualified products.

In this embodiment, the binder is polyvinylpyrrolidone-K30 and absolute ethanol.

In this example, the lubricant is silicon dioxide. In this example, silicon dioxide is replaced with one of magnesium stearate and polyethylene glycol 6000, or silicon dioxide according to the same weight portion. Mixed with magnesium stearate and polyethylene glycol 6000 to obtain qualified products.

In this embodiment, the flavoring agent is strawberry flavor. In this embodiment, the strawberry flavor is replaced with one of sweet orange flavor, artificial flavor, peach flavor, and kiwi flavor according to the same weight portion, or with strawberry. The mixture of flavor and sweet orange flavor, artificial flavor, peach flavor and kiwi flavor are all qualified products.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present embodiment comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity The foaming agent and the filler are mixed evenly, then the binder is added to make granules, sieved and dried at 65°C for 1.5 hours, and then sieved to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation.

Embodiment 4

In the effervescent tablet for preventing heatstroke and fatigue in this embodiment, the raw materials for the effervescent tablet include the following components by weight: 5 parts of Astragalus root extract, 1 part of Rhodiola rosea extract, 5 parts of honeysuckle extract powder, 5 parts of Schisandra chinensis extract 1 part of cream powder, 5 parts of glutamine, 1 part of arginine, 5 parts of aspartic acid, 1 part of taurine, 0.1 part of vitamin B, 0.01 part of vitamin B2, 0.1 part of vitamin B6, 0.5 part of vitamin C , 2 parts of niacinamide, 0.5 parts of inositol, 10 parts of sodium chloride, 0.1 part of potassium chloride, 30 parts of acidic foaming agent, 10 parts of alkaline foaming agent, 60 parts of filler, 1 part of binder, lubricant 10 parts of the agent and 2 parts of the flavoring agent.

In this embodiment, the acidic foaming agent is citric acid. In this embodiment, citric acid is replaced by one of tartaric acid and malic acid, or a mixture of citric acid and tartaric acid and malic acid according to the same weight portion, All qualified products.

In this embodiment, the alkaline foaming agent is sodium carbonate and sodium bicarbonate.

In this embodiment, the filler is lactose. In this embodiment, lactose is replaced by one of fructose, sucrose, glucose, acesulfame potassium, and aspartame, or replaced by lactose and fructose according to the same weight. , sucrose, glucose, acesulfame potassium, aspartame mixture, are qualified products.

In this embodiment, the binder is polyvinylpyrrolidone-K30 and absolute ethanol.

In this embodiment, the lubricant is magnesium stearate. In this embodiment, magnesium stearate is replaced by one of silicon dioxide, polyethylene glycol 6000, or stearin according to the same weight portion. The mixture of magnesium acid, silicon dioxide and polyethylene glycol 6000 is qualified product.

In this embodiment, the flavoring agent is peach essence. In this embodiment, the peach essence is replaced by one of sweet orange essence, strawberry essence, artificial essence, and kiwi essence according to the same weight portion, or replaced with The mixture of peach essence and sweet orange essence, strawberry essence, artificial essence and kiwi fruit essence shall be qualified products.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present embodiment comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity Foaming agent and filler are mixed evenly, then add binder to granulate, sieve and dry at 664°C for 1 hour, then sieve to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation.

Embodiment 5

In the effervescent tablet for preventing heatstroke and fatigue in this embodiment, the raw materials of the effervescent tablet include the following components by weight: 2 parts of Astragalus root extract, 4 parts of Rhodiola rosea extract, 3 parts of honeysuckle extract powder, Schisandra chinensis extract 1 part of cream powder, 4 parts of glutamine, 1 part of arginine, 5 parts of aspartic acid, 3 parts of taurine, 0.01 part of vitamin B1, 0.07 part of vitamin B2, 0.01 part of vitamin B6, 2 parts of vitamin C, 0.8 parts of niacinamide, 1.5 parts of inositol, 3 parts of sodium chloride, 4 parts of potassium chloride, 15 parts of acidic foaming agent, 20 parts of alkaline foaming agent, 50 parts of filler, 1 part of binder, lubricant 8 parts, 6 parts of flavoring agent.

In this embodiment, the acidic foaming agent is citric acid. In this embodiment, citric acid is replaced by one of tartaric acid and malic acid, or a mixture of citric acid and tartaric acid and malic acid according to the same weight portion, All qualified products.

In this embodiment, the alkaline foaming agent is sodium carbonate.

In this embodiment, the filler is acesulfame-K. In this embodiment, acesulfame-K is replaced with one of fructose, sucrose, lactose, glucose, aspartame according to the same weight portion, or replaced with acesulfame-K The mixture of simi and fructose, sucrose, lactose, glucose and aspartame are qualified products.

In this embodiment, the adhesive is polyvinylpyrrolidone-K30.

In this embodiment, the lubricant is magnesium stearate. In this embodiment, magnesium stearate is replaced by one of silicon dioxide, polyethylene glycol 6000, or stearin according to the same weight portion. The mixture of magnesium acid, silicon dioxide and polyethylene glycol 6000 is qualified product.

In this embodiment, the flavoring agent is kiwifruit essence. In this embodiment, the kiwifruit essence is replaced by one of sweet orange essence, strawberry essence, peach essence, artificial essence, or kiwifruit essence according to the same weight. The mixture of essence and sweet orange essence, strawberry essence, peach essence and artificial essence shall be qualified products.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present embodiment comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity The foaming agent and the filler are mixed evenly, then the binder is added to make granules, sieved and dried at 65°C for 1.5 hours, and then sieved to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation.

Embodiment 6

In the effervescent tablet for preventing heat stroke and anti-fatigue in this embodiment, the raw materials for the effervescent tablet include the following components by weight: 3 parts of Astragalus root extract, 3 parts of Rhodiola rosea extract, 3 parts of honeysuckle extract powder, Schisandra chinensis extract 3 parts of cream powder, 3 parts of glutamine, 3 parts of arginine, 3 parts of aspartic acid, 3 parts of taurine, 0.05 part of vitamin B1, 0.05 part of vitamin B2, 0.05 part of vitamin B6, 1.2 part of vitamin C, 0.6 parts of niacinamide, 1.2 parts of inositol, 5 parts of sodium chloride, 2.5 parts of potassium chloride, 20 parts of acidic foaming agent, 20 parts of alkaline foaming agent, 40 parts of filler, 3 parts of binder, lubricant 6 parts, 6 parts of flavoring agent.

In this embodiment, the acidic foaming agent is citric acid. In this embodiment, citric acid is replaced by one of tartaric acid and malic acid, or a mixture of citric acid and tartaric acid and malic acid according to the same weight portion, All qualified products.

In this embodiment, the alkaline foaming agent is sodium bicarbonate.

In this embodiment, the filler is glucose. In this embodiment, glucose is replaced by one of fructose, sucrose, lactose, acesulfame potassium, and aspartame, or glucose and fructose are replaced by equal parts by weight. , sucrose, lactose, acesulfame potassium, aspartame mixture, are qualified products.

In this embodiment, the adhesive is polyvinylpyrrolidone-K30 and absolute ethanol.

In this embodiment, the lubricant is magnesium stearate. In this embodiment, magnesium stearate is replaced by one of silicon dioxide, polyethylene glycol 6000, or stearin according to the same weight portion. The mixture of magnesium acid, silicon dioxide and polyethylene glycol 6000 is qualified product.

In this embodiment, the flavoring agent is an artificial flavor. In this embodiment, the artificial flavor is replaced with one of sweet orange flavor, strawberry flavor, peach flavor, and kiwi flavor according to the same weight, or an artificial flavor. The mixture of flavor and sweet orange flavor, strawberry flavor, peach flavor and kiwi flavor are all qualified products.

The preparation method of the effervescent tablet for preventing heatstroke and fatigue of the present embodiment comprises the following steps:

a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles;

b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity The foaming agent and the filler are mixed evenly, then the binder is added to make granules, sieved and dried at 65°C for 1.2 hours, and then sieved to obtain acidic granules;

c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation.

The anti-heatstroke and anti-fatigue effervescent tablet of Example 1 was used in animal experiments:

(1) 40 C57BL/6 mice were randomly divided into control group, low-dose group, middle-dose group and high-dose group, with 10 mice in each group. The control group was given distilled water as daily drinking water. In the low-dose group, the middle-dose group and the high-dose group, the daily drinking water of the mice was replaced by the effervescent tablet beverage of the present invention with different concentrations. The diet is the same. Drink continuously for 30 days, and record the weight change. The experimental results were judged as significant differences among the groups with p<0.05.

(2) Determination of weight-bearing swimming time

When the mice were subjected to the weight-bearing swimming exhaustion experiment, an iron wire of 5.5% of their body weight was added to 1 cm at the base of the tail, so that they could freely move to exhaustion in a water tank with a depth of 50 cm and a temperature of (25.5±0.5) °C, and timing.

(3) After the mice were anesthetized by intraperitoneal injection of 50 mg/kg sodium pentobarbital, the orbital blood was collected, centrifuged at 3000 rpm for 30 minutes at 4°C, and the serum was collected, aliquoted, and stored at -80°C for the determination of serum biochemical indicators. detection. Serum lactate content, liver superoxide dismutase activity, liver malondialdehyde and glutathione content were determined by kits; blood glucose, serum urea nitrogen, and serum lactate dehydrogenase were detected by automatic biochemical analyzer.

(4) Twenty-four C57BL/6 mice were taken for heat-resistant experiments. Mice stopped eating and drinking before entering the cabin, and all mice were placed in a specific environment intelligent simulation experimental cabin (China, Tianjin Hope, HOPE-MED8105E), the simulated cabin temperature (41.2±0.5) ℃, humidity (60±0.2) %, the condition for exiting the cabin that meets the heatstroke standard is that the mouse rectal temperature reaches (42.4±0.2) ℃. The rectal temperature of the mice was continuously monitored, and when the rectal temperature reached 42.4±0.2°C, the mice were taken out of the cabin, and the time and weight of the mice were recorded.

Table 1 Influence of the effervescent tablet beverage of the present invention on the body weight of mice

group Dose (g/L) Initial body weight (g) Final weight (g) Weight gain (g) control group 0.0 24.0±1.8 31.4±1.3 7.5±0.8 low dose group 5.0 23.8±1.2 31.5±1.7 7.7±0.6 medium dose group 10.0 23.6±1.5 31.8±1.1 8.1±0.6* high dose group 15.0 23.9±1.3 31.7±1.1 7.8±0.5

Note: * means compared with blank control group, p<0.05; ** means compared with blank control group, p<0.01.

Table 2 The influence of the effervescent tablet beverage of the present invention on the weight-bearing swimming time of mice

group Dose (g/L) swimming time(s) P value control group 0.0 225.80±33.64 — low dose group 5.0 257.07±41.80 0.247 medium dose group 10.0 285.90±27.55** 0.004 high dose group 15.0 284.30±42.46** 0.006

Note: * means compared with blank control group, p<0.05; ** means compared with blank control group, p<0.01.

The influence of table 3 effervescent tablet beverage of the present invention on mouse serum biochemical indexes

Note: * means compared with blank control group, p<0.05; ** means compared with blank control group, p<0.01.

Table 4 Influence of the effervescent tablet beverage of the present invention on the antioxidant capacity of mouse liver

Note: * means compared with blank control group, p<0.05; ** means compared with blank control group, p<0.01

Table 5 Influence of the effervescent tablet beverage of the present invention on the degree of heat resistance of mice

Note: * means compared with blank control group, p<0.05; ** means compared with blank control group, p<0.01

Conclusion: According to the present invention, the average daily intake concentration of effervescent tablet beverage is 10g/L, and three concentration dose groups are respectively set, namely low dose group 5g/L, middle dose group 10g/L, high dose group 15g/L, and at the same time The control group was given distilled water. SPF grade C57BL/6 mice were used, given the same diet, and given different concentrations of the effervescent tablet beverage of the present invention for 30 consecutive days to replace the daily drinking water of the mice. The results show:

(1) There was no significant difference in the body weight of mice between each group and the control group.

(2) Compared with the control group, the middle-dose group and the high-dose group can significantly prolong the weight-bearing swimming time of mice.

(3) The serum biochemical indexes of urea nitrogen and lactate concentration in mice were significantly lower than those in the middle-dose group and high-dose group, while blood glucose and lactate dehydrogenase were significantly higher than those in the middle-dose group and high-dose group. control group.

(4) Both the middle-dose group and the high-dose group increased the concentrations of SOD and glutathione, which were significantly different from those of the control group.

(5) With the increase of the concentration of the effervescent tablet beverage of the present invention, the heat-resistant time of mice under the same thermal environment is significantly prolonged.

Based on the results of various tests, it is determined that the effervescent tablet beverage of the present invention has the functions of preventing heatstroke and fatigue.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be Modifications or equivalent replacements without departing from the spirit and scope of the technical solutions of the present invention should be included in the scope of the claims of the present invention.

Claims (10)

1. an effervescent tablet for preventing heat stroke and anti-fatigue, it is characterized in that: described effervescent tablet raw material comprises the following components by weight: 1-5 parts of Astragalus extract, 1-5 parts of Rhodiola rosea extract, honeysuckle flower 1-5 parts of extract powder, 1-5 parts of Schisandra chinensis extract powder, 1-5 parts of glutamine, 1-5 parts of arginine, 1-5 parts of aspartic acid, 1-5 parts of taurine, Vitamin B1 0.01-0.1 part, vitamin B2 0.01-0.1 part, vitamin B6 0.01-0.1 part, vitamin C 0.5-2 part, niacinamide 0.1-2 part, inositol 0.5-2 part, sodium chloride 0.5-10 part , 0.1-5 parts of potassium chloride, 10-30 parts of acidic foaming agent, 10-30 parts of alkaline foaming agent, 20-60 parts of filler, 1-5 parts of adhesive, 2-10 parts of lubricant, 2-10 flavoring agents. 2. The effervescent tablet for preventing heat stroke and anti-fatigue according to claim 1, is characterized in that: the raw material for the effervescent tablet comprises the following components by weight: 3 parts of Astragalus root extract, 3 parts of Rhodiola rosea extract, 3 parts honeysuckle extract powder, 3 parts Schisandra extract powder, 3 parts glutamine, 3 parts arginine, 3 parts aspartic acid, 3 parts taurine, 0.05 part of vitamin B1, 0.05 part of vitamin B2, vitamin B6 0.05 parts, vitamin C 1.2 parts, niacinamide 0.6 parts, inositol 1.2 parts, sodium chloride 5 parts, potassium chloride 2.5 parts, acid foaming agent 20 parts, alkaline foaming agent 20 parts, filler 40 parts , 3 parts of adhesive, 6 parts of lubricant, 6 parts of flavoring agent. 3. The effervescent tablet for preventing heatstroke and fatigue according to claim 2, wherein the acidic foaming agent is one or more mixtures of citric acid, tartaric acid and malic acid. 4. The effervescent tablet for preventing heatstroke and fatigue according to claim 3, wherein the alkaline foaming agent is one or both of sodium carbonate and sodium bicarbonate. 5. The effervescent tablet for preventing heatstroke and fatigue according to claim 4, wherein the filler is one or both of glucose, fructose, sucrose, lactose, acesulfame potassium and aspartame mixture of the above. 6 . The effervescent tablet for preventing heatstroke and fatigue according to claim 5 , wherein the adhesive is one or both of polyvinylpyrrolidone-K30 and dehydrated alcohol. 7 . 7. The effervescent tablet of preventing heat stroke and anti-fatigue according to claim 6, is characterized in that: described lubricant is one or more mixtures in magnesium stearate, silicon dioxide, polyethylene glycol 6000 The flavoring agent is one or more mixtures of artificial flavor, sweet orange flavor, strawberry flavor, peach flavor, and kiwi flavor. 8. the preparation method of the effervescent tablet of preventing heat stroke and anti-fatigue according to claim 1, is characterized in that: comprise the following steps: a. Heat the lubricant to a molten state, add astragalus extract, Rhodiola rosea extract, alkali foaming agent, nicotinamide, sodium chloride, potassium chloride and filler, stir and mix evenly, crush and sieve after cooling to obtain alkaline particles; b. Honeysuckle extract powder, Schisandra extract powder, glutamine, arginine, aspartic acid, taurine, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin C, inositol, acidity Mix the foaming agent and filler evenly, then add the binder to granulate, sieve and dry at 60-70°C for 1-2 hours, then sieve to obtain acidic granules; c. Mix the acidic granules, the alkaline granules and the flavoring agent in proportion to uniformly, and press the tablet to obtain an effervescent tablet formulation. 9. the preparation method of the effervescent tablet of preventing heat stroke and anti-fatigue according to claim 8, is characterized in that: in step b, described honeysuckle extract powder is prepared in the following manner: the honeysuckle after drying is pulverized, After sieving, use 95% (V/V) ethanol for continuous reflux extraction, filter the extract and concentrate under reduced pressure to constant weight to obtain honeysuckle extract, then mix honeysuckle extract with auxiliary materials, and spray dry to obtain honeysuckle extract pink. 10. The preparation method of the effervescent tablet for preventing heat stroke and anti-fatigue according to claim 9, is characterized in that: in step b, described Schisandra chinensis extract powder is prepared in the following manner: pulverizing, sieving after drying Schisandra chinensis 95% ethanol is used for continuous reflux extraction, the extract is filtered and concentrated under reduced pressure to constant weight to obtain Schisandra chinensis extract, then the Schisandra chinensis extract is mixed with auxiliary materials, and spray-dried to obtain Schisandra chinensis extract powder.