CN114451428A - Disinfection and sterilization effervescent tablet and preparation method thereof - Google Patents
Disinfection and sterilization effervescent tablet and preparation method thereof Download PDFInfo
- Publication number
- CN114451428A CN114451428A CN202210111718.2A CN202210111718A CN114451428A CN 114451428 A CN114451428 A CN 114451428A CN 202210111718 A CN202210111718 A CN 202210111718A CN 114451428 A CN114451428 A CN 114451428A
- Authority
- CN
- China
- Prior art keywords
- effervescent tablet
- effervescent
- acer truncatum
- disinfection
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 83
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 50
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 241000219226 Acer truncatum Species 0.000 claims abstract description 40
- 241000366182 Melaleuca alternifolia Species 0.000 claims abstract description 36
- 239000000341 volatile oil Substances 0.000 claims abstract description 31
- 239000000284 extract Substances 0.000 claims abstract description 27
- 239000003094 microcapsule Substances 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 150000007524 organic acids Chemical class 0.000 claims abstract description 8
- 239000000645 desinfectant Substances 0.000 claims abstract description 7
- 150000007529 inorganic bases Chemical class 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000008187 granular material Substances 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 16
- 238000002386 leaching Methods 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 229920002472 Starch Polymers 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000008107 starch Substances 0.000 claims description 14
- 235000019698 starch Nutrition 0.000 claims description 14
- 238000005550 wet granulation Methods 0.000 claims description 14
- 235000015165 citric acid Nutrition 0.000 claims description 13
- 239000004793 Polystyrene Substances 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 229920002223 polystyrene Polymers 0.000 claims description 12
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 9
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- 239000003826 tablet Substances 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 239000000741 silica gel Substances 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 230000000249 desinfective effect Effects 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims description 4
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims description 4
- 229920000858 Cyclodextrin Polymers 0.000 claims description 4
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- 229920000881 Modified starch Polymers 0.000 claims description 4
- 239000004368 Modified starch Substances 0.000 claims description 4
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims description 4
- 229940074393 chlorogenic acid Drugs 0.000 claims description 4
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims description 4
- 235000001368 chlorogenic acid Nutrition 0.000 claims description 4
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 235000019426 modified starch Nutrition 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000011162 core material Substances 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 235000015424 sodium Nutrition 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 238000004042 decolorization Methods 0.000 claims 1
- 229930003935 flavonoid Natural products 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- 235000017173 flavonoids Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 150000002212 flavone derivatives Chemical class 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 2
- 229910021487 silica fume Inorganic materials 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229930006978 terpinene Natural products 0.000 description 2
- 150000003507 terpinene derivatives Chemical class 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 241001143500 Aceraceae Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000378467 Melaleuca Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 229910001504 inorganic chloride Inorganic materials 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Botany (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of effervescent tablet manufacturing, and discloses a disinfection and sterilization effervescent tablet and a preparation method thereof, in particular to a disinfection and sterilization effervescent tablet taking acer truncatum leaf extract and melaleuca alternifolia essential oil microcapsules as active components and a preparation method thereof; the disinfection and sterilization effervescent tablet comprises the following components in percentage by weight: 20-40% of acer truncatum leaf extract, 10-25% of melaleuca alternifolia essential oil microcapsule, 10-35% of organic acid, 5-25% of inorganic base and the balance of effervescent tablet auxiliary materials to 100%. The effervescent tablet has good disinfection and sterilization effects, the disinfection and sterilization rate is higher than that of common disinfectants in the market, the effervescent tablet is non-toxic and non-irritant, and meanwhile, the effervescent tablet is convenient to carry and store, can be quickly disintegrated in water, is convenient to use, takes effect quickly, and has unique preparation method, simple process flow and low cost.
Description
Technical Field
The invention relates to the field of daily chemical disinfection and sterilization agent effervescent tablets, in particular to a disinfection and sterilization effervescent tablet and a preparation method thereof, and especially relates to a disinfection and sterilization effervescent tablet taking acer truncatum leaf extract and melaleuca alternifolia essential oil microcapsules as active components and a preparation method thereof.
Background
Along with the improvement of living standard of people, more and more families have higher and higher requirements on living environment sanitation, so that the development of disinfection and sterilization products which are convenient to use, efficient and environment-friendly is urgently needed.
Most of the disinfection and sterilization agents used in the current market are inorganic chloride salts, such as bleaching powder, disinfection and sterilization tablets, disinfection and sterilization powder, 84 disinfection and sterilization liquid and the like, and formaldehyde, chlorine dioxide, potassium permanganate, potassium persulfate, emulsified plant essential oil and the like, and the defects of poor stability, short disinfection and sterilization duration, slag after dissolution, poor oxidation performance, large liquid amount of part of product packages, extremely high transportation and storage cost and short quality guarantee period generally exist. The effervescent tablet uses organic acid and carbonate (hydrogen) salt to react to be an effervescent disintegrant, and can immediately carry out an effervescent reaction when being put into water, so as to release substances in the effervescent tablet and generate a disinfectant solution at any time. Can not meet different requirements of various industries in society.
Acer Truncatum Bunge (Acer Truncatum Bunge), also known as Acer Truncatum Bunge, is a fallen leaf tree of Aceraceae, and is named because its wing fruit is shaped like an ancient "gold ingot". Belongs to a special tree species in China. The compound fertilizer is rich in various secondary metabolites and bioactive substances, has various benefits of medicine, oil, tannin, chemical industry, greening, appreciation, water and soil conservation and the like, and has high development and utilization values. The acer truncatum leaf extract contains abundant flavone and chlorogenic acid, has obvious degerming effect, can resist alkaline environment, has stronger inoxidizability, and has better inhibitory activity on escherichia coli, staphylococcus aureus, salmonella, hemolytic streptococcus, bacillus subtilis and pseudomonas aeruginosa. Low cost, easy obtaining and high safety.
Melaleuca alternifolia (Melaleuca alternifolia Cheel) is also called Australia tea tree, belongs to Myrtaceae Melaleuca, is native to Australia southern latitude 23.5 ° coastal areas and northern areas of northern territory, and is known as Australia national treasure. In the 90 s of the 20 th century, melaleuca alternifolia seeds were successfully introduced in Guangdong, Guangxi, Hainan, Fujian, Yunnan and the like in China, and a certain planting scale was formed, and in recent years, a large amount of melaleuca alternifolia seeds were planted in the south of China. According to the discovery and the proof of modern science and technology and medical clinical tests, the melaleuca alternifolia (Australia tea tree) essential oil contains various chemical components such as terpineol, terpinene, eucalyptol, p-cymene, limonene, terpinene and the like, is a powerful broad-spectrum disinfection and sterilization substance, has stronger inhibitory activity capability and the effects of resisting bacteria, disinfecting and sterilizing, inhibiting bacteria, activating immune cells and the like on 57 clinical 58 bacteria, fungi, molds and viruses in the nature, has the disinfection and sterilization effect 11-13 times that of carbolic acid, and is listed in the purchase record of the Food and Drug Administration (FDA); the European pharmacopoeia was also included in 2001.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to develop a novel antibacterial cleaning effervescent tablet which has strong stability, broad spectrum and high efficiency, can be quickly disintegrated in water in a short time when in use, is non-toxic and has no stimulation and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a disinfection and sterilization effervescent tablet and a preparation method thereof are disclosed, which mainly comprises the following raw materials by weight: 20-40% of acer truncatum leaf extract, 10-25% of melaleuca alternifolia essential oil microcapsule, 10-35% of organic acid, 5-25% of inorganic base and effervescent tablet auxiliary materials, wherein the balance is 100%.
Further, the organic acid is any one of malic acid, citric acid and tartaric acid; the inorganic base is any one of sodium carbonate, sodium bicarbonate, potassium carbonate and potassium bicarbonate.
Further, the raw materials comprise the following components in parts by weight: 31% of acer truncatum leaf extract, 18% of melaleuca alternifolia essential oil microcapsule, 25% of citric acid, 20% of sodium bicarbonate and effervescent tablet auxiliary materials, and the balance is up to 100%.
Furthermore, the effervescent tablet auxiliary materials comprise an adhesive, a release agent and a disintegrating agent. Wherein the adhesive is polystyrene pyrrolidone; the release agent is any one of carboxymethyl cellulose, superfine silica gel powder, magnesium stearate and talcum powder; the disintegrating agent is any one of dry starch, croscarmellose sodium and sodium carboxymethyl starch.
Further, the acer truncatum leaf extract is prepared by taking acer truncatum leaves as a raw material, cleaning and drying the acer truncatum leaves, crushing the acer truncatum leaves, leaching the acer truncatum leaves for 1 to 2 hours at the temperature of 60 to 80 ℃ by using 7 to 10 times of ethanol with the weight percentage concentration of 50 to 70% under the assistance of ultrasonic waves, filtering the obtained product to obtain a leaching solution A, leaching the residues for 1 to 2 hours at the temperature of 60 to 80 ℃ by using 4 to 5 times of ethanol with the weight percentage concentration of 50 to 70% under the assistance of ultrasonic waves, filtering the obtained product to obtain a leaching solution B, and combining the leaching solutions A, B; concentrating under reduced pressure to recover ethanol, adsorbing by NKA-9 macroporous resin, washing with water for decoloration, eluting by 60-70% of ethanol, concentrating the eluent by a double-effect membrane, and performing spray drying to obtain the acer truncatum leaf extract with the total flavone content of 26-28% and the chlorogenic acid content of 17-20%.
Further, the melaleuca alternifolia essential oil microcapsule is melaleuca alternifolia essential oil microcapsule powder with a coating rate of 58-60% obtained by coating with a saturated aqueous solution, carrying out high-pressure homogenization and spray drying by using modified starch, beta-cyclodextrin and Arabic gum as wall materials and melaleuca alternifolia essential oil as a core material.
A preparation method of a disinfection and sterilization effervescent tablet comprises the following steps:
s1, uniformly mixing 20-40% of acer truncatum leaf extract, 10-25% of melaleuca alternifolia essential oil microcapsule, 10-35% of organic acid and an adhesive, and performing wet granulation and drying to obtain a first granule;
s2, uniformly mixing 5-25% of inorganic base and a disintegrating agent, and performing wet granulation and drying to obtain a second granule;
s3, uniformly mixing the first granules, the second granules and the release agent, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
The invention has the beneficial effects that:
the disinfection and sterilization effervescent tablet has high disintegration speed in water; the disinfectant has the characteristics of no toxicity, no stimulation, good disinfection and sterilization effects, stable performance and the like, has low manufacturing cost, is very suitable for disinfection and sterilization in public places such as households, schools, hospitals, aviation and the like and industrial use, and is also very suitable for disinfection and sterilization in the laundry process and daily disinfection and sterilization of pets and the like. Meanwhile, the effervescent tablet has high safety of raw materials, easily obtained raw materials, simple preparation method and easy realization of industrial production.
Detailed Description
The present invention is described in further detail by the following description of specific embodiments, it is to be understood that these embodiments are merely illustrative of the present invention and are not intended to limit the scope of the invention, which is defined by the appended claims, and that modifications of various equivalent forms of the present invention by those skilled in the art after reading the present invention are within the scope of the appended claims.
All the raw materials and reagents of the invention are conventional market raw materials and reagents unless otherwise specified.
The present invention will be further illustrated with reference to the following specific embodiments.
The acer truncatum leaf extract is extracted by the following method:
cleaning and airing acer truncatum leaves, crushing, leaching for 1-2 hours at 60-80 ℃ by using 7-10 times of ethanol with the weight percentage concentration of 50-70% under the assistance of ultrasonic waves, filtering to obtain a leaching solution A, leaching residues for 1-2 hours at 60-80 ℃ by using 4-5 times of ethanol with the weight percentage concentration of 50-70% under the assistance of ultrasonic waves, filtering to obtain a leaching solution B, and combining the leaching solution A, B; concentrating under reduced pressure to recover ethanol, adsorbing by NKA-9 macroporous resin, washing with water for decoloration, eluting by 60-70% of ethanol, concentrating the eluent by a double-effect membrane, and performing spray drying to obtain the acer truncatum leaf extract with the total flavone content of 26-28% and the chlorogenic acid content of 17-20%.
The melaleuca alternifolia essential oil microcapsule is prepared by the following steps:
dissolving modified starch or beta-cyclodextrin and Arabic gum in hot water to prepare a saturated solution, dissolving melaleuca alternifolia essential oil in ethanol, adding the melaleuca alternifolia essential oil ethanol solution into an aqueous solution of the modified starch or beta-cyclodextrin and Arabic gum under stirring, stirring for 1-2 hours, homogenizing for 2 times under 25-35 MPa and spray drying to obtain melaleuca alternifolia essential oil microcapsule powder with an encapsulation rate of 58-60%.
In a specific embodiment, the acer truncatum leaf extract and melaleuca alternifolia essential oil microcapsule powder obtained in the above manner is adopted.
Example 1:
the invention provides a disinfection and sterilization effervescent tablet which comprises the following components in percentage by weight:
31% of acer truncatum leaf extract, 18% of melaleuca alternifolia essential oil microcapsule, 25% of citric acid and 20% of sodium bicarbonate. (ii) a 0.5 percent of polystyrene pyrrolidone, 1.5 percent of magnesium stearate and 4.0 percent of sodium carboxymethyl starch.
The preparation method of the disinfection bactericide effervescent tablet comprises the following steps:
uniformly mixing the acer truncatum leaf extract, melaleuca alternifolia essential oil microcapsules, citric acid and polystyrene pyrrolidone, and performing wet granulation and drying to obtain first granules;
uniformly mixing sodium bicarbonate and sodium carboxymethyl starch, and performing wet granulation and drying to obtain a second granule;
and uniformly mixing the first granule, the second granule and magnesium stearate, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
Example 2:
the invention provides a disinfection and sterilization effervescent tablet which comprises the following components in percentage by weight:
35% of acer truncatum leaf extract, 15% of melaleuca alternifolia essential oil microcapsule, 24% of citric acid and 22% of sodium carbonate. (ii) a 0.5 percent of polystyrene pyrrolidone, 1.0 percent of micro silica gel powder and 2.5 percent of sodium carboxymethyl starch.
The preparation method of the disinfection bactericide effervescent tablet comprises the following steps:
uniformly mixing the acer truncatum leaf extract, melaleuca alternifolia essential oil microcapsules, citric acid and polystyrene pyrrolidone, and performing wet granulation and drying to obtain first granules;
mixing sodium carbonate and sodium carboxymethyl starch uniformly, and performing wet granulation and drying to obtain a second granule;
and uniformly mixing the first granules, the second granules and the superfine silica gel powder, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
Example 3:
the invention provides a disinfection and sterilization effervescent tablet which comprises the following components in percentage by weight:
25% of acer truncatum leaf extract, 25% of melaleuca alternifolia essential oil microcapsule, 28% of malic acid and 22% of sodium bicarbonate. (ii) a 0.5 percent of polystyrene pyrrolidone, 1.0 percent of micro silica gel powder and 2.5 percent of sodium carboxymethyl starch.
The preparation method of the disinfection bactericide effervescent tablet comprises the following steps:
uniformly mixing the acer truncatum leaf extract, melaleuca alternifolia essential oil microcapsules, citric acid and polystyrene pyrrolidone, and performing wet granulation and drying to obtain first granules;
mixing sodium carbonate and sodium carboxymethyl starch uniformly, and performing wet granulation and drying to obtain a second granule;
and uniformly mixing the first granules, the second granules and the superfine silica gel powder, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
Comparative example 1:
the invention provides a disinfection and sterilization effervescent tablet which comprises the following components in percentage by weight:
55% of acer truncatum leaf extract, 21% of citric acid and 19% of sodium bicarbonate. (ii) a 0.5 percent of polystyrene pyrrolidone, 1.5 percent of magnesium stearate and 3.0 percent of sodium carboxymethyl starch.
The preparation method of the disinfection bactericide effervescent tablet comprises the following steps:
uniformly mixing the acer truncatum leaf extract, citric acid and polystyrene pyrrolidone, and performing wet granulation and drying to obtain a first granule;
uniformly mixing sodium bicarbonate and sodium carboxymethyl starch, and performing wet granulation and drying to obtain a second granule;
and uniformly mixing the first granules, the second granules and magnesium stearate, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
Comparative example 2:
the invention provides a disinfection and sterilization effervescent tablet which comprises the following components in percentage by weight:
50% of melaleuca alternifolia essential oil microcapsule, 24% of citric acid, 22% of sodium carbonate, 0.5% of polystyrene pyrrolidone, 1.0% of micropowder silica gel and 2.5% of sodium carboxymethyl starch.
The preparation method of the disinfection bactericide effervescent tablet comprises the following steps:
uniformly mixing melaleuca alternifolia essential oil microcapsules, citric acid and polystyrene pyrrolidone, and performing wet granulation and drying to obtain first granules;
uniformly mixing sodium bicarbonate and sodium carboxymethyl starch, and performing wet granulation and drying to obtain a second granule;
and uniformly mixing the first granule, the second granule and magnesium stearate, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
The compositions of examples 1 to 3 and comparative examples 1 to 2 are shown in Table 1.
TABLE 1 compositions of examples and comparative examples (% by weight)
Next, the sterilizing effervescent tablets of the present invention were tested for bacteriostatic properties.
And (3) detecting the antibacterial performance: the experimental method is implemented according to GB/T15979-2012 hygienic Standard for Disposable hygienic articles, and the microbial strains are as follows: coli (ATCC8739), Candida albicans (ATCC10231), and Staphylococcus aureus (ATCC 6538), examples 1-3 and comparative examples 1-2 were tested under 1:100 dilution according to appendix C4.
TABLE 2 bacteriostasis rates (%)
| Test example | Escherichia coli | Candida albicans | Staphylococcus aureus |
| Example 1 | 99.99 | 99.99 | 99.99 |
| Example 2 | 99.52 | 99.66 | 99.55 |
| Example 3 | 99.23 | 99.75 | 99.68 |
| Comparative example 1 | 68.63 | 71.82 | 66.75 |
| Comparative example 2 | 73.47 | 74.12 | 78.44 |
。
As can be seen from table 2, the bacteriostatic rate of the aqueous solution obtained from the effervescent tablets provided in examples 1 to 3 on staphylococcus aureus, escherichia coli and candida albicans exceeds 99.5%, which indicates that the effervescent tablets provided by the invention have unexpectedly excellent disinfection and sterilization effects.
As can be seen from comparison between examples 1-3 and comparative examples 1-2, the effervescent tablet provided by the invention has better inhibitory effects on staphylococcus aureus, escherichia coli and candida albicans through the synergistic effect of the acer truncatum leaf extract and the melaleuca alternifolia essential oil microcapsules.
In general, the lack of any one or the improper ratio of the parts can cause the bacteriostatic (disinfecting) effect to be greatly weakened.
The above examples are only intended to illustrate the detailed process of the present invention, and the present invention is not limited to the above detailed process, i.e., it is not intended that the present invention necessarily depends on the above detailed process for its implementation. It is understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. The disinfection and sterilization effervescent tablet is characterized by comprising the following components in percentage by weight: 20-40% of acer truncatum leaf extract, 10-25% of melaleuca alternifolia essential oil microcapsule, 10-35% of organic acid, 5-25% of inorganic base and the balance of effervescent tablet auxiliary materials to 100%.
2. The effervescent disinfectant tablet as set forth in claim 1, wherein the components thereof comprise, in weight percent: 31% of acer truncatum leaf extract, 18% of melaleuca alternifolia essential oil microcapsule, 25% of citric acid, 20% of sodium bicarbonate and effervescent tablet auxiliary materials, and the balance is up to 100%.
3. The effervescent tablet of claim 1, wherein the acer truncatum leaf extract contains 26-28% of total flavonoids and 17-20% of chlorogenic acid.
4. The effervescent disinfecting and sterilizing tablet as claimed in any one of claims 1 to 3, wherein: the organic acid is any one of malic acid, citric acid and tartaric acid.
5. The effervescent disinfecting and sterilizing tablet as claimed in any one of claims 1 to 3, wherein: the inorganic base is any one of sodium carbonate, sodium bicarbonate, potassium carbonate and potassium bicarbonate.
6. The effervescent disinfecting and sterilizing tablet as claimed in any one of claims 1 to 3, wherein: the effervescent tablet auxiliary materials comprise an adhesive, a release agent and a disintegrating agent.
7. The effervescent disinfectant tablet of claim 6 wherein: the adhesive is polystyrene pyrrolidone.
8. The effervescent disinfectant tablet of claim 6 wherein: the release agent is any one of carboxymethyl cellulose, superfine silica gel powder, magnesium stearate and talcum powder.
9. The effervescent disinfectant tablet of claim 6 wherein: the disintegrating agent is any one of dry starch, croscarmellose sodium and sodium carboxymethyl starch.
10. A method for preparing a disinfecting and sterilizing effervescent tablet as claimed in any one of claims 1 to 9, which comprises the following steps:
s1, preparing the acer truncatum leaf extract, including: taking acer truncatum leaves as a raw material, cleaning and airing the acer truncatum leaves, crushing the acer truncatum leaves, leaching the acer truncatum leaves for 1 to 2 hours at the temperature of 60 to 80 ℃ by using 7 to 10 times of ethanol with the weight percentage concentration of 50 to 70 percent under the assistance of ultrasonic waves, filtering the crushed acer truncatum leaves to obtain a leaching solution A, leaching residues by using 4 to 5 times of ethanol with the weight percentage concentration of 50 to 70 percent under the assistance of ultrasonic waves for 1 to 2 hours at the temperature of 60 to 80 ℃, filtering the leaching solution to obtain a leaching solution B, and combining the leaching solutions A, B; concentrating under reduced pressure to recover ethanol, adsorbing by NKA-9 macroporous resin, washing with water for decolorization, eluting by 60-70% ethanol, concentrating the eluate by a double-effect membrane, and spray drying to obtain the acer truncatum leaf extract;
s2, preparing the melaleuca alternifolia essential oil microcapsule, including: modified starch, beta-cyclodextrin and Arabic gum are used as wall materials, melaleuca alternifolia essential oil is used as a core material, and melaleuca alternifolia essential oil microcapsule powder with the wrapping rate of 58-60% is obtained by wrapping with a saturated aqueous solution, high-pressure homogenizing and spray drying;
s3, uniformly mixing 20-40% of acer truncatum leaf extract, 10-25% of melaleuca alternifolia essential oil microcapsule, 10-35% of organic acid and an adhesive, and performing wet granulation and drying to obtain a first granule;
s4, uniformly mixing 5-25% of inorganic base and a disintegrating agent, and performing wet granulation and drying to obtain a second granule;
s5, uniformly mixing the first granules, the second granules and the release agent, and quantitatively tabletting to obtain the disinfection and sterilization effervescent tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210111718.2A CN114451428B (en) | 2022-01-26 | 2022-01-26 | Disinfection and sterilization effervescent tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210111718.2A CN114451428B (en) | 2022-01-26 | 2022-01-26 | Disinfection and sterilization effervescent tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114451428A true CN114451428A (en) | 2022-05-10 |
| CN114451428B CN114451428B (en) | 2023-04-11 |
Family
ID=81410949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210111718.2A Active CN114451428B (en) | 2022-01-26 | 2022-01-26 | Disinfection and sterilization effervescent tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114451428B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130337095A1 (en) * | 2012-06-18 | 2013-12-19 | Waikatolink Limited | Antimicrobial composition and its method of use |
| CN103611155A (en) * | 2013-12-11 | 2014-03-05 | 西南林业大学 | Australia tea tree effervescent tablet and preparation method thereof |
| CN106691895A (en) * | 2016-12-28 | 2017-05-24 | 安徽紫檀科技有限公司 | Antiperspirant dew for preventing and treating bromhidrosis and preparation method thereof |
| CN110896969A (en) * | 2018-09-17 | 2020-03-24 | 中国医学科学院药用植物研究所 | Green sustained-release disinfection effervescent tablet and preparation method thereof |
| CN111603425A (en) * | 2020-06-02 | 2020-09-01 | 意润健康产业（广州）有限公司 | Multifunctional effervescent tablet of skin disinfection cleaning solution and preparation method thereof |
-
2022
- 2022-01-26 CN CN202210111718.2A patent/CN114451428B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130337095A1 (en) * | 2012-06-18 | 2013-12-19 | Waikatolink Limited | Antimicrobial composition and its method of use |
| CN103611155A (en) * | 2013-12-11 | 2014-03-05 | 西南林业大学 | Australia tea tree effervescent tablet and preparation method thereof |
| CN106691895A (en) * | 2016-12-28 | 2017-05-24 | 安徽紫檀科技有限公司 | Antiperspirant dew for preventing and treating bromhidrosis and preparation method thereof |
| CN110896969A (en) * | 2018-09-17 | 2020-03-24 | 中国医学科学院药用植物研究所 | Green sustained-release disinfection effervescent tablet and preparation method thereof |
| CN111603425A (en) * | 2020-06-02 | 2020-09-01 | 意润健康产业（广州）有限公司 | Multifunctional effervescent tablet of skin disinfection cleaning solution and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 任红剑，丰震，王超: "元宝枫花的挥发成分研究", 《天津农业科学》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114451428B (en) | 2023-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101841137B1 (en) | Feminine cleanser composition and preparing method thereof | |
| CN103864512B (en) | A kind of nano biological environment protection multifunctional organic bamboo vinegar medicine is fertile | |
| CN101305738A (en) | Agricultural mixed formulation constituted by chitosan oligosaccharide or the like | |
| CN102423291A (en) | Traditional Chinese medicine antibacterial skin-care hand sanitizer and preparation method thereof | |
| CN101669643A (en) | Chrysanthemum tea effervescent tablets and preparation method thereof | |
| CN102090700A (en) | Tartary buckwheat-flavone compounded natural bacteriostatic agent | |
| CN101999356A (en) | Sterilization composition containing fluopicolide and metalaxyl and application thereof | |
| CN101427676A (en) | Phenolactone aqueous emulsion and preparation method thereof | |
| CN117136967A (en) | Biostimulant capable of preventing and treating plant fungal diseases and preparation method thereof | |
| CN113402626A (en) | Nymphaea hybrid polysaccharide extract and preparation method and application thereof | |
| CN117751951A (en) | Mixed preparation for preventing and treating plant diseases and application thereof | |
| CN103263476A (en) | Composite bacteriostatic agent for reducing irritation | |
| CN114451428B (en) | Disinfection and sterilization effervescent tablet and preparation method thereof | |
| CN105733853A (en) | Sun block and repair sea buckthorn fruit cold-processed handmade soap and preparing method thereof | |
| CN102251438A (en) | A kind of antibacterial disinfection fragrance toilet paper and its manufacturing method | |
| CN107551274A (en) | A kind of animal antifungal preparation and preparation method thereof | |
| CN101554161A (en) | Dimethomorph-mancozeb water dispersible granule and preparation method thereof | |
| CN110012904A (en) | A kind of trichloroisocyanuric acid effervescent disinfection tablet and preparation method thereof | |
| CN101524068B (en) | Dibromo hydantoin fast dissolving tablet | |
| CN101647439B (en) | Mixed sterilization combination containing boscalid | |
| CN106833995A (en) | The antibacterial laundry soap of infant plant and its production method | |
| CN111345326A (en) | Natural plant disinfection effervescent tablet and preparation method thereof | |
| CN107198080A (en) | A kind of medicinal and edible plant extract effervescent tablet and preparation method thereof | |
| CN103563898A (en) | Chitosan wettable powder | |
| CN107517956A (en) | A kind of fresh-keeping fresh-keeping composition and preparation method thereof of environmentally friendly landscape flower |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |