CN114486176B - Confocal distance imaging calibration device and calibration method - Google Patents
Confocal distance imaging calibration device and calibration method Download PDFInfo
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- CN114486176B CN114486176B CN202210081863.0A CN202210081863A CN114486176B CN 114486176 B CN114486176 B CN 114486176B CN 202210081863 A CN202210081863 A CN 202210081863A CN 114486176 B CN114486176 B CN 114486176B
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- 238000003384 imaging method Methods 0.000 title claims abstract description 74
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000005286 illumination Methods 0.000 claims abstract description 14
- 238000010226 confocal imaging Methods 0.000 claims description 8
- 230000005499 meniscus Effects 0.000 claims description 6
- 238000004026 adhesive bonding Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000004458 analytical method Methods 0.000 abstract description 2
- 238000012014 optical coherence tomography Methods 0.000 description 30
- 238000010586 diagram Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
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- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000002577 ophthalmoscopy Methods 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
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Abstract
The invention discloses a confocal distance imaging calibration device and a calibration method, wherein the device comprises the following components: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera; the lighting unit emits light sources of two different wavelengths; a cross center target is arranged in the middle of the target element, and light emitted by the lighting unit is emitted into the collimating lens through the target element; the collimating lens collimates the light emitted by the lighting unit; the reflecting mirror is used for reflecting the light collimated by the collimating lens to the scanning lens unit; the scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope; the spectroscope reflects the projected light to the calibration camera. According to the confocal distance imaging calibration device and the calibration method, the confocal distance adjustment is carried out on the OCT and SLO fundus imaging systems in a light spot quality analysis mode, so that subjective errors caused by an eye observation method are avoided, and the calibration are more reliable. And the debugging time of the production process is saved, and the overall efficiency is improved.
Description
Technical Field
The invention relates to a confocal distance imaging calibration device and a calibration method.
Background
OCT (Optical Coherence Tomography) utilizes weak coherent light to interfere, detects signals of different depth layers of tissues, and obtains a three-dimensional image through scanning. SLO (SCANNING LASER Ophthalmoscopy) uses linear light reflected back into the human eye to obtain detailed images of structures behind the eye, such as the retina, optic nerve, and blood vessels. The laser light passes through the back of the eye and the reflected light is used to form an image which can be used to display changes in the eye in real time or to create a three dimensional image for OCT navigator scanning.
In the system, the problem of inconsistent wavelengths of the OCT optical path and the SLO optical path exists, and the problem is that when OCT imaging is optimal, the SLO cannot meet the optimal imaging requirement, otherwise, when SLO imaging is optimal, the OCT imaging cannot meet the optimal imaging requirement.
The existing debugging process is too subjective and depends on subjective judgment of debugging personnel, and has no certain standard basis, so that errors caused subjectively are unavoidable. In addition, the existing method requires two debugging personnel to cooperate with the debugging party to finish the calibration and calibration process, so that human resources are wasted in the production process.
Disclosure of Invention
The invention provides a confocal distance imaging calibration device and a calibration method for solving the technical problems, which concretely adopts the following technical scheme:
The confocal distance imaging calibration device is used for OCT and SLO fundus imaging systems, wherein the OCT and SLO fundus imaging systems comprise an OCT imaging subsystem and an SLO imaging subsystem, and the confocal distance imaging calibration device comprises: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera;
The illumination unit, the target element, the collimating lens, the reflecting mirror, the scanning lens unit, the spectroscope and the calibration camera are sequentially arranged according to the propagation direction of the light path;
the calibration camera is arranged at the human eye information acquisition position of the OCT and SLO fundus imaging system and used for simulating human eyes;
the spectroscope is arranged in a main light path of the OCT and SLO fundus imaging system;
the lighting unit is switchable to emit light sources with two different wavelengths;
A cross center target is arranged in the middle of the target element, and light emitted by the lighting unit passes through the target element and then enters the collimating lens;
The collimating lens is used for collimating the light emitted by the lighting unit;
the reflecting mirror is used for reflecting the light collimated by the collimating lens to the scanning lens unit;
The scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope;
the spectroscope reflects the projected light to the calibration camera.
Further, the lighting unit includes a mounting plate, a first light source, a second light source, a power source, and a start switch.
The first light source and the second light source are arranged on the same side of the mounting plate;
the power supply is arranged on the mounting plate and is electrically connected to the first light source and the second light source;
The starting switch is arranged on the mounting plate and is electrically connected to the power supply, the first light source and the second light source for switching on or off the lighting unit.
Further, the lighting unit further comprises a switch-on light;
The change-over switch is arranged on the mounting plate and electrically connected to the power supply, the first light source and the second light source for switching the light-emitting states of the first light source and the second light source.
Further, the first light source comprises a plurality of first light emitters;
The second light source comprises a plurality of second light emitters.
The first and second light emitters are LEDs.
Further, the start switch and the change-over switch are the same element.
Further, the first light source is a near infrared light source;
The second light source is a white light source.
Further, the scanning lens unit is a double cemented lens;
The scanning lens unit is formed by gluing a convex lens and a negative meniscus concave lens.
Further, the refractive index of the collimator lens is 1.52;
The focal length of the collimating lens is 75mm;
The refractive index of the convex lens is 1.56;
The refractive index of the negative meniscus concave lens is 1.62;
The focal length of the scanning lens unit is 60mm.
A confocal distance imaging calibration method is used for the confocal distance imaging calibration device and comprises the following steps:
turning on an illumination unit, adjusting the illumination unit to emit a light source with a first wavelength, and projecting a cross wire engraved on a target element to a sensor of a calibration camera;
Adjusting the reflector to enable the cross hair of the target element to coincide with the cross hair of the system target of the OCT and SLO fundus imaging system;
adjusting the lighting unit to emit a light source of a second wavelength;
Closing a light source of the SLO imaging subsystem, opening the light source of the OCT imaging subsystem, and adjusting the focal length position of a first collimating lens of the OCT imaging subsystem to enable the half-peak height width of a received light spot of a sensor of a calibration camera to meet a preset condition;
and then turning on a light source of the SLO imaging subsystem, turning off the light source of the OCT imaging subsystem, and adjusting the focal length position of a second collimating lens of the SLO imaging subsystem to ensure that the half-peak width of a received light spot of a sensor of a calibration camera also meets a preset condition.
Further, the light source of the first wavelength is white light;
The light source of the second wavelength is near infrared light.
The confocal distance imaging calibration device and the confocal distance imaging calibration method have the advantages that the confocal distance adjustment is carried out on the OCT and SLO fundus imaging systems in a light spot quality analysis mode, subjective errors caused by an eye observation method are avoided, and calibration are more reliable. And the debugging time of the production process is saved, and the overall efficiency is improved.
Drawings
FIG. 1 is a schematic diagram of a confocal imaging calibration apparatus of the present invention;
FIG. 2 is a schematic diagram of the confocal imaging calibration apparatus of the present invention applied to OCT and SLO fundus imaging systems;
FIG. 3 is a schematic illustration of a target element of the present invention;
FIG. 4 is a schematic view of an illumination unit of a target element of the present invention;
Fig. 5 is a schematic view of a scanning lens unit of the present invention.
Detailed Description
The invention is described in detail below with reference to the drawings and the specific embodiments.
Fig. 1 shows a confocal distance imaging calibration device of the application, which is used for adjusting OCT and SLO fundus imaging systems. As shown in fig. 2, a schematic diagram of the application of the confocal distance imaging calibration device to an OCT and SLO fundus imaging system, wherein the OCT and SLO fundus imaging system includes an OCT imaging subsystem and an SLO imaging subsystem. The confocal distance imaging calibration device is used for adjusting the OCT imaging subsystem and the SLO imaging subsystem to make the OCT imaging subsystem and the SLO imaging subsystem have a common focal length.
In the present application, the confocal imaging calibration apparatus includes: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera. The illumination unit, the target element, the collimating lens, the reflecting mirror, the scanning lens unit, the spectroscope and the calibration camera are sequentially arranged according to the propagation direction of the light path. The calibration camera is arranged at the human eye information acquisition position of the OCT and SLO fundus imaging system and used for simulating human eyes. The spectroscope is arranged in the main light path of the OCT and SLO fundus imaging systems.
In particular, the lighting unit is switchable to emit light sources of two different wavelengths. The center of the cross is arranged in the middle of the target element, and the light emitted by the lighting unit passes through the target element and then enters the collimating lens, as shown in fig. 3. The collimating lens is used for collimating the light emitted by the lighting unit. The reflecting mirror is used for reflecting the light collimated by the collimating lens to the scanning lens unit. The scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope. The spectroscope reflects the projected light to the calibration camera.
The adjusting method of the confocal distance imaging calibration device comprises the following steps: the illumination unit is turned on, adjusted to emit a light source of a first wavelength, and the projection of the cross hair inscribed on the target element is projected onto a sensor of the calibration camera. The centerline scale of the target pattern provides a calibration location for adjusting the center spot. Specifically, there is also a cross center system target before calibrating the camera. The mirror is adjusted so that the cross hair of the target element coincides with the cross hair of the system target of the OCT and SLO fundus imaging system. The lighting unit is tuned to emit a light source of a second wavelength. And turning off a light source of the SLO imaging subsystem, turning on the light source of the OCT imaging subsystem, and adjusting the focal length position of a first collimating lens of the OCT imaging subsystem to enable the half-peak width of a received light spot of a sensor of a calibration camera to meet a preset condition. And then turning on a light source of the SLO imaging subsystem, turning off the light source of the OCT imaging subsystem, and adjusting the focal length position of a second collimating lens of the SLO imaging subsystem to ensure that the half-peak width of a received light spot of a sensor of a calibration camera also meets a preset condition. At the moment, the imaging positions of the two light paths reach the confocal distance requirement, namely, the confocal distance adjustment of the OCT and SLO fundus imaging systems is completed.
The method for measuring the half-peak width is a general means in industry, so that the half-peak width meets the actual use requirement of the system, and the specific value is measured according to the system requirement and will not be described in detail here.
As shown in fig. 4, the lighting unit includes a mounting plate, a first light source, a second light source, a power source, and a start switch. The first light source and the second light source are arranged on the same side of the mounting plate. The power supply is arranged on the mounting plate and electrically connected to the first light source and the second light source. The starting switch is arranged on the mounting plate and is electrically connected to the power supply, the first light source and the second light source for switching on or off the lighting unit.
Preferably, the lighting unit further comprises a switch-on light. The change-over switch is arranged on the mounting plate and electrically connected to the power supply, the first light source and the second light source for switching the light-emitting states of the first light source and the second light source.
In the present application, the first light source comprises a plurality of first light emitters. The second light source comprises a plurality of second light emitters. The first and second light emitters are LEDs. Wherein the first light source is a near infrared light source. The second light source is a white light source.
Specifically, the first light source and the second light source are arranged in a graphical manner, wherein 1,3, 5, 7 and 9 are near infrared LEDs, and 2, 4, 6 and 8 are white LEDs.
In the present application, the start switch and the change-over switch are the same element. In the initial state, both the near infrared LED and the white LED are turned off. Pressing the switch once turns on the white light LED, pressing the switch twice turns off the white light LED and turns on the near infrared LED, and pressing the switch third time turns off the near infrared LED. In this way, one start switch member can be reduced.
As a preferred embodiment, the scanning lens unit is a doublet lens, as shown in fig. 5. Specifically, the scanning lens unit is formed by gluing a convex lens and a negative meniscus concave lens.
Preferably, in the present application, the refractive index of the collimating lens is 1.52, and the focal length of the collimating lens is 75mm. The refractive index of the convex lens is 1.56, and the refractive index of the negative meniscus concave lens is 1.62. The focal length of the scanning lens unit is 60mm.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be appreciated by persons skilled in the art that the above embodiments are not intended to limit the invention in any way, and that all technical solutions obtained by means of equivalent substitutions or equivalent transformations fall within the scope of the invention.
Claims (8)
1. A confocal distance imaging calibration device for OCT and SLO fundus imaging systems including an OCT imaging subsystem and an SLO imaging subsystem, the confocal distance imaging calibration device comprising: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera;
the illumination unit, the target element, the collimating lens, the reflecting mirror, the scanning lens unit, the spectroscope and the calibration camera are sequentially arranged according to the propagation direction of the light path;
The calibration camera is arranged at a human eye information acquisition position of the OCT and SLO fundus imaging system and used for simulating human eyes;
the spectroscope is arranged in a main light path of the OCT and SLO fundus imaging system;
The lighting unit is switchable to emit light sources with two different wavelengths;
A cross center target is arranged in the middle of the target element, and light emitted by the illumination unit passes through the target element and then enters the collimating lens;
the collimating lens is used for collimating the light emitted by the lighting unit;
the reflecting mirror is used for reflecting the light collimated by the collimating lens to the scanning lens unit;
the scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope;
the spectroscope reflects the projected light to the calibration camera;
The lighting unit comprises a mounting plate, a first light source, a second light source, a power supply and a starting switch;
the first light source and the second light source are arranged on the same side of the mounting plate;
the power supply is arranged on the mounting plate and is electrically connected to the first light source and the second light source;
The starting switch is arranged on the mounting plate and is electrically connected to the power supply, the first light source and the second light source for switching on or off the lighting unit;
The lighting unit further comprises a switch;
the change-over switch is arranged on the mounting plate and is electrically connected to the power supply, the first light source and the second light source for switching the light-emitting states of the first light source and the second light source.
2. The confocal imaging calibration apparatus of claim 1, wherein,
The first light source comprises a plurality of first light emitters;
the second light source comprises a plurality of second light emitters;
The first light emitter and the second light emitter are LEDs.
3. The confocal imaging calibration apparatus of claim 1, wherein,
The start switch and the change-over switch are the same element.
4. The confocal imaging calibration apparatus of claim 1, wherein,
The first light source is a near infrared light source;
The second light source is a white light source.
5. The confocal imaging calibration apparatus of claim 1, wherein,
The scanning lens unit is a double-cemented lens;
the scanning lens unit is formed by gluing a convex lens and a negative meniscus concave lens.
6. The confocal imaging calibration apparatus of claim 5, wherein,
The refractive index of the collimating lens is 1.52;
the focal length of the collimating lens is 75mm;
the refractive index of the convex lens is 1.56;
The refractive index of the negative meniscus concave lens is 1.62;
the focal length of the scanning lens unit is 60mm.
7. A confocal distance imaging calibration method for the confocal distance imaging calibration apparatus of claim 1, comprising the steps of:
Turning on the illumination unit, adjusting the illumination unit to emit a light source with a first wavelength, and projecting the cross hair engraved on the target element to a sensor of the calibration camera;
Adjusting the mirror to coincide the cross hair of the target element with the cross hair of the system target of the OCT and SLO fundus imaging system;
Adjusting the lighting unit to emit a light source of a second wavelength;
Turning off a light source of the SLO imaging subsystem, turning on the light source of the OCT imaging subsystem, and adjusting the focal length position of a first collimating lens of the OCT imaging subsystem to enable the half-peak height width of a received light spot of a sensor of the calibration camera to meet a preset condition;
And turning on a light source of the SLO imaging subsystem, turning off the light source of the OCT imaging subsystem, and adjusting the focal length position of a second collimating lens of the SLO imaging subsystem to enable the half-peak height width of a received light spot of a sensor of the calibration camera to meet a preset condition.
8. The confocal distance imaging calibration method of claim 7, wherein,
The light source of the first wavelength is white light;
The light source of the second wavelength is near infrared light.
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| GB2429522A (en) * | 2005-08-26 | 2007-02-28 | Univ Kent Canterbury | Optical mapping apparatus |
| US20070291277A1 (en) * | 2006-06-20 | 2007-12-20 | Everett Matthew J | Spectral domain optical coherence tomography system |
| JP5685013B2 (en) * | 2010-06-30 | 2015-03-18 | キヤノン株式会社 | Optical tomographic imaging apparatus, control method therefor, and program |
| JP6118986B2 (en) * | 2013-01-30 | 2017-04-26 | サンテック株式会社 | Optical tomographic image display device for ophthalmology |
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| JP2017205261A (en) * | 2016-05-18 | 2017-11-24 | キヤノン株式会社 | Ophthalmic imaging apparatus, control method therefor, and program |
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| JP7395803B2 (en) * | 2017-08-14 | 2023-12-12 | オプトス ピーエルシー | ophthalmology equipment |
| WO2019117036A1 (en) * | 2017-12-14 | 2019-06-20 | キヤノン株式会社 | Image capturing device and control method thereof |
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