CN114554973B - Sampling device - Google Patents

Abstract

A sampling device comprises a shell, wherein a chamber is arranged in the shell, and the shell opens an opening after entering a sampling site for a sample to enter the chamber. The sampling device provided by the present invention can be swallowed, and after swallowing, the opening is opened in the body to extract digestive tract fluid, thereby avoiding the pain imposed on the user during traditional disease screening and sample collection, and realizing convenient, comfortable and safe digestive tract fluid extraction.

Description

Sampling device

Technical Field

The present invention relates to a sampling device, in particular to an in vivo sampling device.

Background Art

Gastric juice analysis can fully understand the secretion, motility and digestive function of the stomach, and is used to detect the function of the stomach and diagnose related diseases. It has been an important method and approach for clinical diagnosis for many years. In recent years, studies have confirmed that gastric juice analysis is of great significance for the diagnosis of diseases such as gastrinoma, gastric ulcer, various types of gastritis, gastric cancer, gastrointestinal flora, infection, and cancer screening.

Gastric fluid analysis has unique value in studying drug efficacy, such as determining the effect of antacids and other drugs in treating ulcers and gastritis, studying the secretory function of the stomach, and dynamically observing changes in gastric function. Clinically, it can be used to help decide on surgical methods and determine surgical results. Similarly, intestinal fluid analysis also plays a very important role in intestinal function analysis, intestinal disease diagnosis, drug efficacy research, and surgical method effect judgment.

At present, the conventional method for collecting gastric juice is to insert a plastic tube into the forestomach through the esophagus from the mouth, perfuse with physiological saline with a pH of 7.0 and a temperature of about 35° at a flow rate of 12 ml/h, collect the effluent, and analyze it. Therefore, the conventional method of extracting gastric juice has the following disadvantages: a) it is difficult to swallow, insertion is painful, and the user experience is poor; b) it requires professional personnel to operate, and the slightest negligence will injure the esophagus or stomach; and c) the extraction time is long. In summary, it is poor in safety, difficult to operate, and brings pain to users. Intestinal fluid collection is even more difficult, and the pain it brings to users is even greater.

Summary of the invention

In order to solve the above and other potential problems of the prior art, it is necessary to propose a sampling device.

An embodiment of the present invention provides a sampling device, which includes a shell, wherein a chamber is arranged in the shell, and after the shell enters a sampling site, an opening of the shell is opened to allow a sample to enter the chamber.

Furthermore, the shell is provided with the opening; and the sampling device further comprises:

a cover body disposed on the opening; a force-bearing portion disposed on the cover body;

a force-applying portion disposed on the housing, the force-applying portion being used to apply force to the force-receiving portion so that the force-receiving portion actuates the cover to expose the opening for the sample to enter the chamber from the opening;

A control unit is used to control the force-applying unit to apply force or stop applying force to the force-receiving unit.

Furthermore, the sampling device further comprises a resetting portion, and the resetting portion is used to restore the cover body to an initial position to cover the opening after the sampling specimen enters the interior of the shell.

Further, the reset part includes the control part, the force-applying part and the force-receiving part, and the force-applying part applies force to the force-receiving part under the control of the control part, so that the force-receiving part actuates the cover body to move in the opposite direction to cover the opening; or, the reset part includes a rebound member, and the rebound member is used to restore the cover body to its initial position after the force-applying part stops applying force.

Furthermore, the sampling device further comprises a detector, which is used to detect whether the sampled specimen enters the interior of the shell and provide the detection result to the control unit so that the control unit controls the force applying unit according to the detection result.

Furthermore, the sampling device also includes a detector, which is used to detect whether the sampling device reaches the location of the sampling specimen and provide the detection result to the control unit so that the control unit controls the force applying unit according to the detection result.

Furthermore, the detector is a pH detector, and/or the sampling device is a digestive tract fluid sampling device, and/or the sampling device is in the shape of a capsule.

Furthermore, the force-applying part is a chargeable and dischargeable coil, and the force-receiving part is a magnetic part.

Furthermore, the sampling device also includes a wireless communication module, and the wireless communication module is used to communicate with an electronic device.

Furthermore, the sampling device further comprises a positioning module, and the positioning module is used to provide the electronic device with location information of the sampling device through the wireless communication module.

Furthermore, the control unit is also used to control the force applying unit to apply force or stop applying force to the force receiving unit according to a control instruction of the electronic device.

Furthermore, the sampling device also includes a detection material, which is arranged in the chamber and is used to detect specific substances in the sample specimen entering the chamber.

Furthermore, the sampling device also includes a reading device, and the reading device is used to read the changes in the detection material. The wireless communication module is also used to send the output of the reading device to the electronic device.

Furthermore, a liquid absorbing material is arranged in the chamber.

Furthermore, the shell or part of the shell is made of a specific material, and the specific material changes at the sampling site so that the shell presents the opening; or, the shell or part of the shell is made of a gel that is sensitive to pH, and the gel shrinks at the sampling site so that the shell presents the opening.

Further, the opening of the shell is filled or blocked with a specific material, and the specific material changes at the sampling site to make the opening conductive; or, the opening of the shell is filled or blocked with a gel that is sensitive to pH, and the gel shrinks at the sampling site to make the opening conductive.

Furthermore, a detachable collecting device is provided in the chamber for collecting the sample specimens and for carrying the collected sample specimens out of the chamber under the action of external force.

Furthermore, a semipermeable membrane is arranged on the shell.

Furthermore, a first chamber and a second chamber are provided in the shell, the first chamber and the second chamber are sealed and separated from each other, the first chamber is used to hold a sample specimen, and the opening is provided corresponding to the first chamber.

Furthermore, the second chamber is used to place the control unit.

Furthermore, the sampling device is used to sample digestive fluid in the digestive tract.

Furthermore, the width of the sampling device is less than or equal to 3 cm.

Furthermore, a connecting line is provided on the outside of the sampling device.

Furthermore, a mark is provided on the connecting line.

The sampling device provided in the embodiment of the present invention can enter the human body by swallowing, open an opening in the body to extract gastric juice or other digestive tract fluid, and then be discharged from the body with feces or through the mouth or esophagus. The collected gastric juice or other digestive tract fluid is then analyzed in vitro to know the user's health status, avoiding the pain inflicted on the user during traditional disease screening and specimen collection, and realizing convenient, comfortable and safe digestive tract fluid extraction.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments of the present invention will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

FIG. 1 is a schematic diagram of a sampling device in a first embodiment of the present invention.

FIG. 2 is a schematic diagram of the sampling device shown in FIG. 1 with its cover opened.

FIG. 3 is an exemplary circuit control diagram of the sampling device shown in FIG. 1 .

FIG. 4 is a schematic diagram of a fixed connection line of the sampling device shown in FIG. 1 .

FIG. 5 is a schematic diagram of a sampling device in a second embodiment of the present invention.

FIG. 6 is a schematic diagram of a sampling device in a third embodiment of the present invention.

FIG. 7 is a schematic diagram of a sampling device in a fourth embodiment of the present invention.

FIG. 8 is a schematic diagram of a sampling device in a fifth embodiment of the present invention.

FIG. 9 is a schematic diagram of a sampling device in a sixth embodiment of the present invention.

FIG. 10 is a schematic diagram of a sampling device in a seventh embodiment of the present invention.

FIG. 11 is a schematic diagram of a sampling device in an eighth embodiment of the present invention.

12a and 12b are schematic diagrams of a sampling device in a ninth embodiment of the present invention.

The following specific implementation manner will further illustrate the present invention in conjunction with the above-mentioned drawings.

Main component symbols

DETAILED DESCRIPTION

The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

It should be noted that when a component is referred to as being "fixed to" or "mounted on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "set on" another component, it may be directly set on the other component or there may be a central component at the same time. The term "and/or" as used herein includes all and any combinations of one or more of the relevant listed items.

Please refer to FIG. 1 and FIG. 2, which are schematic diagrams of a sampling device in an embodiment of the present invention. The sampling device 1 includes a shell 11, a cover 12, a force-applying portion 13, a force-bearing portion 14, and a control portion 15. The shell 11 is provided with an opening 111. The cover 12 is covered on the opening 111. The force-bearing portion 14 is disposed on the cover 12. The force-applying portion is located inside the shell 11, and is used to apply force to the force-bearing portion 14, so that the force-bearing portion 14 actuates the cover 12 to expose the opening 111 for the sample specimen to enter the shell 11 from the opening 111. The control portion 15 is used to control the force-applying portion 13 to apply force or stop applying force to the force-bearing portion 14. Furthermore, the sampling device 1 also includes a reset portion, which is used to restore the cover 12 to an initial position to cover the opening 111 after the sample specimen enters the shell 11, so as to prevent the sample specimen from flowing out of the opening 111. In this embodiment, the resetting part includes a control part 15 , a force applying part 13 and a force receiving part 14 . The force applying part 13 applies force to the force receiving part 14 under the control of the control part 15 , so that the force receiving part 14 actuates the cover body 12 to move in the opposite direction to cover the opening 111 .

The sampling device 1 may be in the shape of a capsule. Specifically, in this embodiment, the opening 111 is provided at one end of the shell 11, and the cover 12 includes a fixing portion 121 and an opening and closing portion 122, wherein the fixing portion 121 is connected to the shell 11, and the opening and closing portion 122 may move relative to the shell 11, such as rotating around the fixing portion 121, to expose or cover the opening 111. The force-bearing portion 14 is provided on the cover 12, and the situation in which the force-bearing portion 14 is provided on the cover 12 may be at least one of the following situations: a. The force-bearing portion 14 is fixed to a certain place of the cover 12 by pasting or other mechanical fixing methods; b. The force-bearing portion 14 constitutes a certain part of the cover 12, such as the force-bearing portion 14 constitutes one layer of the cover 12: the outermost layer, the innermost layer or a certain middle layer; c. The force-bearing portion 14 constitutes the entire cover 12, in other words, the cover 12 is the force-bearing portion 14. In this embodiment, the force-bearing portion 14 is a magnetic member, fixed to a certain position of the cover 12 by pasting or other mechanical fixing methods. In one example, the force-bearing portion 14 can be set at the position of the cover 12 farthest from the fixing portion 121 to increase the sensitivity of the cover 12 when opening and closing.

The force applying part 13 and the control part 15 are both disposed inside the housing 11. In this embodiment, a circuit board 16 is installed inside the housing 11, and the force applying part 13 and the control part 15 are both disposed on the circuit board 16. The force applying part 13 is a chargeable and dischargeable coil, and the control part 15 controls the charging and discharging of the coil, thereby generating a magnetic field to generate an attractive pulling force or a repulsive thrust on the force receiving part 14.

In this embodiment, the sampling device 1 further includes a detector, which is a position detector 17. The position detector 17 is arranged on the outside of the shell 11 and is used to detect whether the sampling device 1 reaches the location of the sampling specimen. For example, when the sampling specimen is gastric fluid, the position detector 17 is used to detect whether the sampling device 1 reaches the location of the gastric fluid - the stomach, and provides the detection result to the control unit 15 so that the control unit 15 controls the force applying unit 13 according to the detection result.

In this embodiment, the sampling device 1 also includes a detector, which is an in-shell specimen detector 18. The in-shell specimen detector 18 is arranged inside the shell 11, and is used to detect whether the sampling specimen enters the shell 11, and provide the detection result to the control unit 15, so that the control unit 15 controls the force applying part 13 according to the detection result.

When the sample is gastric juice, the position detector 17 and the sample detector 18 in the housing can both be pH detectors, and the pH detector can be composed of a gel sensitive to pH. Of course, the position detector 17 and the sample detector 18 in the housing can also be other suitable detectors, which are not limited here.

Furthermore, the interior of the shell 11 can be divided into at least two chambers: a first chamber 112 and a second chamber 113, the first chamber 112 and the second chamber 113 are sealed and separated from each other, wherein the first chamber 112 is used to store the sample specimen, the opening 111 is arranged corresponding to the first chamber 112, and the sample detector 18 in the shell is arranged inside the first chamber 112. The second chamber 113 is used to place the circuit board 16 and the electronic components arranged thereon. The sealing separation between the second chamber 113 and the first chamber 112 can prevent the sample specimen from contaminating or damaging the force-applying part 13, the control part 15 and other components, and also prevent the force-applying part, the control part 15 and other components from contaminating the sample specimen.

The working principle of the sampling device 1 is described below in conjunction with FIG. 3 .

Please refer to FIG. 3 , which is an exemplary circuit diagram of the sampling device 1. Except for the position detector 17 and the sample detector 18 in the shell, the wiring and other electronic components shown in the circuit diagram can be arranged on the circuit board 16. The control unit 15 includes a first control subunit 151 and a second control subunit 152, wherein the first control subunit 151 is used to control the force-applying part 13 to apply force to the force-receiving part 14 to expose the opening 111. Specifically, one end of the first control subunit 151 is connected to the position detector 17, and the other end is connected to the force-applying part 13 and a power supply unit 19, so as to control the power supply of the force-applying part 13 according to the detection result provided by the position detector 17. The first control subunit 151 includes a first comparison unit 1511, a first switch unit 1512 controlled by the first comparison unit 1511, and a first reference providing unit 1513 that provides a comparison reference to the first comparison unit 1511. The first switch unit 1512 is placed between the force-applying part 13 and the power supply unit 19 to control the power supply of the force-applying part 13. In this embodiment, the first comparison unit 1511 is a comparator 1511a, wherein one input end of the comparator 1511a is connected to the position detector 17, the other input end is connected to the first reference providing unit 1513, and one output end is connected to the first switch unit 1512. The comparator 1511a compares the detection result provided by the position detector 17 with the comparison reference provided by the first reference providing unit 1513, and controls the on-off of the first switch unit 1512 according to the comparison result. Taking gastric juice as an example, the pH value of gastric juice is between 0.9 and 1.8, the position detector 17 detects the pH value of the surrounding environment, and the first reference providing unit 1513 provides a comparison reference of, for example, a pH value of 2.0. When the position detector 17 detects that the surrounding pH value is lower than 2.0, it means that the sampling device 1 has reached the stomach, and the comparator 1511a outputs a first level to control the first switch unit 1512 to close, thereby connecting the power supply unit 19 and the force applying part 13, and supplying power to the force applying part 13. In this embodiment, the first switch unit 1512 is a normally open switch, which is closed only when the comparator 1511a outputs the first level.

The second control subunit 152 is used to control the force-applying part 13 to apply a reverse force to the force-receiving part 14 to cover the opening 111, so as to prevent the sample specimen entering the first chamber 112 from flowing out of the opening 111. Specifically, one end of the second control subunit 152 is connected to the specimen detector 18 in the shell, and the other end is connected to the force-applying part 13 and the power supply unit 19, and the force-applying part 13 is controlled according to the detection result provided by the specimen detector 18 in the shell. The second control subunit 152 includes a second comparison unit 1521, a second switch unit 1522 controlled by the second comparison unit 1521, and a second reference providing unit 1523 that provides a comparison reference to the second comparison unit 1521. The second switch unit 1522 is placed between the force-applying part 13 and the power supply unit 19 to control the power supply of the force-applying part 13. Specifically, in this embodiment, the second switch unit 1522 and the first switch unit 1512 are connected in series between the force-applying part 13 and the power supply unit 19. The second switch unit 1522 is a normally closed switch, which will be disconnected only when the second comparison unit 1521 outputs the second level. Still taking the above-mentioned gastric juice sampling as an example, the second reference providing unit 1523 provides a comparison reference of, for example, a pH value of 2.0. When the sample detector 18 in the housing detects that the pH value of the surrounding environment is lower than 2.0, it means that the sample has entered the housing 11. The second comparison unit 1521 outputs the second level to control the second switch unit 1522 to disconnect, thereby disconnecting the connection between the power supply unit 19 and the force applying part 13.

When the sampling device 1 reaches the stomach and the position detector 17 detects that the pH value of the surrounding environment is lower than 2.0, the first switch unit 1512 is controlled to be closed. At this time, the first switch unit 1512 and the second switch unit 1522 are both in a closed state, and the power supply unit 19 supplies power to the force-applying part 13. The current in the force-applying part 13 gradually increases, and the gradually increasing current generates a first magnetic field. The first magnetic field generates a thrust on the force-bearing part 14, thereby actuating the cover body 12 to expose the opening 111. The sampled gastric fluid flows into the housing 11 from the opening 111. When the sample detector 18 in the housing detects that the pH value of the surrounding environment is lower than 2.0, the second switch unit 1522 is controlled to be disconnected, the connection between the force-applying part 13 and the power supply unit 19 is disconnected, the current in the force-applying part 13 becomes smaller, and a second magnetic field opposite to the first magnetic field is generated. The second magnetic field generates a pulling force on the force-bearing part 14, and the force-bearing part 14 actuates the cover body 12 to cover the opening 111.

It is understood that the cover 12 and the housing 11 can also be fixed by means of a mechanism engagement or friction force, so as to prevent the cover 12 from being easily opened when the force-applying portion 13 no longer applies force to the force-receiving portion 14. For example, when the second switch unit 1522 is disconnected and the current in the force-applying portion 13 is reduced to 0, the second magnetic field disappears, and the cover 12 is no longer subjected to the pulling force. At this time, the cover 12 needs to rely on a mechanism engagement or other methods to prevent it from being easily opened.

Further, please refer to FIG. 4 , a connecting line L may be fixed on the sampling device 1. Typically, the connecting line L may be a thin line, one end of which is fixed to the sampling device 1, and the other end may extend outside the body. A mark, such as a mark X marked with a color, is also provided at a specific position on the connecting line L. After the sampling device 1 is swallowed by the user, it can be determined whether the sampling device 1 has reached the preset position based on the length of the connecting line L remaining outside the body, or based on whether the mark X on the connecting line L is still outside the body. In addition, unlike the solution in which the connecting line L is not fixed and the sampling device 1 needs to be discharged from the body with feces for recovery, when the connecting line L is fixed on the sampling device 1, the sampling device 1 can be recovered through the mouth or esophagus.

Please refer to FIG. 5 , which is a sampling device in a second embodiment. The sampling device 2 is substantially the same as the sampling device 1, and the difference lies mainly in the reset portion. The reset portion of the sampling device 2 includes a resilient member 20. One end of the resilient member 20 is fixedly connected to the housing 21, and the other end is fixedly connected to the opening and closing portion 222 of the cover body 12. Under the control of the control unit 25, the force-applying member 23 applies force to the force-bearing member 24, so that when the force-bearing member 24 actuates the cover body 22 to move away from the opening 211, the resilient member 20 deforms and accumulates rebound energy. After the force-applying member 23 stops applying force to the force-bearing member 24, the resilient member 20 recovers its shape and resets the cover body 22. At the same time, the resilient member 20 can also keep the cover body 22 in the initial device until the sampling device 2 is recovered, and the cover body 22 can be moved to expose the opening 211 by overcoming the resistance of the resilient member 20 through external force.

It can be understood that although the above embodiment only exemplifies the sampling of gastric juice, the sampling idea provided by the embodiment of the present invention can also be used for sampling other digestive tract fluids, such as intestinal fluid. Please refer to FIG6, which is a sampling device in the third embodiment. The sampling device 3 includes a positioning system 30, and the positioning system 30 may include a wireless communication module 31 and a positioning module 32. The wireless communication module 31 is used to communicate with an external electronic device W, and the positioning module 32 is used to provide the electronic device W with the location information of the sampling device 3 through the wireless communication module 31. In addition, the control unit 35 of the sampling device 3 may also be different from the control units 15 and 25 of the sampling devices 1 and 2. For example, the control unit 35 of the sampling device 3 can be a microcontroller chip. The control unit 35 receives the control command of the electronic device W according to the wireless communication module 31, and controls the force-applying part 33 to apply force or stop applying force to the force-receiving part 34 according to the control command of the electronic device W. For example, after determining the position of the sampling device 3 according to the position information provided by the positioning module 32 , the electronic device W sends a control instruction to the control unit 35 , and the control unit 35 controls the force applying unit 33 to apply force or stop applying force to the force receiving unit 34 according to the control instruction.

It can be understood that the above embodiments all describe the exposure or shielding of the opening by moving the opening and closing portion of the cover away from or close to the shell. However, in other embodiments, such as shown in FIG. 7 , the cover 42 of the sampling device 4 is sleeved on one end of the shell 41, and the opening 411 on the shell 41 is arranged at a position where the shell 41 and the cover 42 overlap. The cover 42 also has a notch or opening 422 arranged at a position where the cover 42 and the shell 41 overlap. When the force-applying portion 43 applies force to the force-receiving portion 44, the force-receiving portion 44 drives the cover 42 to rotate around the central axis, so that the notch or opening 422 on the cover 42 overlaps or partially overlaps with the opening 411 on the shell 41, so as to expose the opening 411 and allow the sample specimen to enter the shell 41. After the force-applying portion 43 stops applying force, the reset portion forces the cover back to the initial position, so that the notch or opening 422 on the cover 42 deviates from the opening 411 on the shell 41, and the cover 42 shields the opening 411 to prevent the sample specimen from flowing out of the shell 41.

It can be understood that in another embodiment, please refer to Figure 8, the chamber 511 in the shell 51 of the sampling device 5 for storing the sampled specimen can also be filled/placed with a liquid-absorbing material 53 with a certain pore size, such as cotton, polyethersulfone resin and other engineering plastics, etc., to fully absorb the sampled specimen. In addition, food residues can be prevented from entering the chamber 511.

It is understood that in another embodiment, as shown in FIG. 9 , a detachable collection device 63, such as a semipermeable membrane, can be provided on the inner wall of the chamber 611 of the housing 61 of the sampling device 6 for storing the sampled specimens. The detachable collection device 63 can be separated from the housing. After the sampling device 6 is collected in vitro, the detachable collection device 63 and the sampled specimens are separated from the housing 61 manually or with the aid of tools, machines, etc., so as to facilitate the installation of the sampled specimens as a whole on the detection instrument and the reuse of the sampled specimens. It is understood that in another embodiment, the semipermeable membrane can also be provided on the outside of the housing 61 to prevent food residues from entering the sampling device 6.

It can be understood that in another embodiment, please refer to Figure 10, a detection material 73, such as a occult blood test paper, a biomarker test paper or other detection materials, can be placed in the chamber 711 of the shell 71 of the sampling device 7 for storing the sampled specimen to detect whether the sampled specimen contains a specific substance.

It can be understood that in another embodiment, please refer to Figure 11, in addition to the detection material 83, a reading device 85 and a wireless communication module 86 can also be set in the chamber 811 formed by the shell 81 of the sampling device 8, and the reading device 85 is used to read the changes in the detection material 83, and transmit the changes to an electronic device outside the user's body (not shown) through the wireless communication module 86, so that the user can obtain relevant test results.

It can be understood that the reading device 85 and the wireless communication module 86 can be located in the same chamber as the detection material 83. In order to avoid the environment during sampling affecting the reading device 85 and the wireless communication module 86, the reading device 85 and the wireless communication module 86 can be treated with waterproof and anti-corrosion. In addition, the reading device 85 and the wireless communication module 86 can also be located in different chambers from the detection material 83, and the chambers are sealed and separated. The electrodes and part of the wires connected to the reading device 85 and the detection material 83 are located in the chamber where the detection material 83 is located, and can be treated with waterproof and anti-corrosion. The reading device 85 detects the change in conductivity of the detection material 83 through the electrodes connected to the detection material 83, and sends the change in conductivity to the electronic device outside the body through the wireless communication module 86. Alternatively, the reading device 85 can also process the change in conductivity to form an intermediate result or a final result of whether the reaction sample contains a specific substance and/or the content of a specific substance.

In another embodiment, the detection material 83 generates a light signal through a chemical reaction with a specific substance, and the reading device 85 obtains the change of the detection material 83 by reading the light signal, and directly sends the change to an electronic device outside the body through the wireless communication module 86, or processes the change to form an intermediate result or final result of whether the reaction sampling specimen contains a specific substance and/or the content of the specific substance, and sends the intermediate result or final result to an electronic device outside the body through the wireless communication module 86.

It can be understood that in another embodiment, as shown in FIG. 12a and FIG. 12b, the sampling device 9 does not have a separate cover body, and the opening 911 on the shell 91 of the sampling device 9 is filled/blocked with a specific material 93, and the specific material changes in a specific environment to make the opening 911 conductive. For example, the opening 911 on the shell 91 is filled/blocked with a gel that is sensitive to pH value. After the sampling device 9 reaches the sampling site, the stomach, the gel shrinks to make the opening 911 conductive, and the sampled specimen can enter the chamber in the shell through the opening 911. After the sampling device 9 leaves the sampling site, the specific material such as the gel recovers and refills/blocks the opening 911. In one way, the specific material is only located at the opening 911 or blocks the opening 911 from the outside of the shell 91. In another way, the specific material is located in the chamber of the sampling device 9, filling or partially filling the chamber of the sampling device 9.

In another embodiment, the housing or part of the housing of the sampling device is made of the specific material, and the specific material changes in a specific environment so that an opening appears on the housing.

It can be understood that, in the sampling device provided in the above embodiments, the features of one embodiment can be transplanted to other embodiments without contradiction, and the features omitted from drawing and description in any embodiment can refer to the same or similar settings in other embodiments. For example, FIG8-FIG12 and their associated embodiments do not involve the introduction of the circuit board, the control part, the cover, the force-applying part, the force-receiving part, the detector, etc., which means that, as needed, these embodiments can refer to the above embodiments to set these components, and any or all of these components can be omitted.

To sum up, the sampling device provided in the embodiment of the present invention can present a smooth surface and a small volume as a whole, like a capsule. The widest part of the capsule can be less than or equal to 3 cm. The materials that the sampling device contacts with the user can be made of safe materials, such as alloys and polyethylene plastic stools, so that the sampling device can enter the human body by swallowing, extract gastric juice or other digestive tract fluids, and excrete them from the body with feces or through the mouth or esophagus. The collected gastric juice or other digestive tract fluids are analyzed in vitro to know the user's health status. For example, the collected gastric juice can be analyzed, and the bleeding situation can be understood by performing occult blood tests on the gastric juice; the gastric juice secretion situation can be understood by analyzing the pH of the gastric juice; the surgical method of gastric ulcer can be determined by gastric juice analysis, and gastric cancer can be detected by analyzing gastric juice using fluorescence diagnostic technology. After the patient's surgery, regular testing of gastric juice can achieve regular postoperative monitoring. The swallowable sampling device provided in the embodiment of the present invention opens an opening in the body to extract digestive tract fluid, avoiding the pain inflicted on the user during traditional disease screening and specimen collection, and achieving convenient, comfortable and safe digestive tract fluid extraction.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the present invention.

Claims (22)

1. A sampling device is characterized by comprising a shell, wherein a cavity is arranged in the shell, an opening is opened after the shell enters a sampling position for a sampling specimen to enter the cavity,

The shell is provided with the opening; the sampling device further comprises:

A cover body covering the opening;

a force receiving part arranged on the cover body;

The force application part is used for applying force to the force receiving part, so that the force receiving part actuates the cover body to expose the opening for the sampling specimen to enter the cavity from the opening;

a control unit for controlling the urging unit to urge or stop urging the force receiving unit;

the position detector is arranged outside the shell and is used for detecting whether the sampling device reaches the position of a sampling specimen or not and providing a detection result to the control part so that the control part controls the force application part according to the detection result; and

The in-shell sample detector is arranged in the shell, and is used for detecting whether a sampling sample enters the shell or not and providing a detection result to the control part so that the control part controls the force application part according to the detection result;

The control part comprises a first control sub part and a second control sub part, one end of the first control sub part is connected with the position detector, the other end of the first control sub part is connected with the force application part and a power supply unit, the first control sub part is used for controlling the power supply of the force application part according to the detection result provided by the position detector so as to enable the force application part to generate a first magnetic field, and the first magnetic field is used for generating thrust so as to enable the force receiving part to open the opening; one end of the second control sub-part is connected with the in-shell specimen detector, the other end of the second control sub-part is connected with the force application part and the power supply unit, the second control sub-part is used for controlling the power supply of the force application part according to the detection result provided by the in-shell specimen detector so as to enable the force application part to generate a second magnetic field with the opposite direction to the first magnetic field, and the second magnetic field is used for generating pulling force to enable the force application part to seal the opening.

2. The sampling device of claim 1, further comprising a reset portion comprising a resilient member for returning the cover to an initial position after the force application portion ceases to apply the force.

3. The sampling device of claim 1, wherein the detector is a ph detector and/or the sampling device is an in vivo sampling device.

4. The sampling device of claim 1, wherein the sampling device is in the shape of a capsule.

5. The sampling device of claim 1, wherein the force application portion is a chargeable and dischargeable coil and the force receiving portion is a magnetic member.

6. The sampling device of claim 1, further comprising a wireless communication module for communicating with an electronic device.

7. The sampling device of claim 6, further comprising a positioning module for providing location information of the sampling device to the electronic device via the wireless communication module.

8. The sampling device of claim 6, further comprising a detection material disposed within the chamber for detecting a particular substance in a sampled specimen entering the chamber.

9. The sampling device of claim 8, further comprising a reading device for reading the change in the detection material, the wireless communication module further for transmitting an output of the reading device to the electronic device.

10. The sampling device of claim 1, wherein a wicking material is disposed within the chamber.

11. A sampling device according to claim 1, wherein the housing or part of the housing is made of a particular material which changes at the sampling site so that the housing presents the opening.

12. The sampling device of claim 1, wherein the housing or a portion of the housing is made of a pH sensitive gel that contracts at the sampling site to cause the housing to present the opening.

13. The sampling device of claim 1, wherein the opening of the housing is filled or plugged with a particular material that changes at the sampling site to render the opening conductive.

14. The sampling device of claim 1, wherein said opening of said housing is filled or plugged with a pH sensitive gel that contracts at the sampling site to allow said opening to conduct.

15. The sampling device of claim 1, wherein a separable collection device is disposed within the chamber for collecting a sample specimen and for carrying the collected sample specimen away from the chamber under the influence of an external force.

16. A sampling device according to claim 1 or 15, wherein a semipermeable membrane is provided on the housing.

17. The sampling device of claim 1, wherein a first chamber and a second chamber are disposed within the housing, the first chamber and the second chamber being sealed from one another, the first chamber being configured to hold a sampled specimen, the opening being disposed in correspondence with the first chamber.

18. The sampling device of claim 17, wherein the second chamber is configured to house the control portion.

19. The sampling device of claim 1, wherein the sampling device is for sampling digestive fluids in the digestive tract.

20. The sampling device of claim 19, wherein the sampling device has a width of less than or equal to 3cm.

21. The sampling device of claim 19, wherein a connecting wire is provided outside the sampling device.

22. A sampling device according to claim 21, wherein the connection lines are provided with markings.