CN114681723A - Precise inhalation administration atomizer - Google Patents

Abstract

The invention discloses a precision inhalation and drug delivery atomizer, comprising an atomizing micro-orifice plate, a reinforcing substrate and a fixing device. The liquid at one end exerts pressure and the other end shoots atomized droplets. The reinforcing substrate is used to support the atomized microplate to improve the strength. The fixing device is composed of an atomizing nozzle, a fixing plug and an atomizer jacket. The front end of the atomizing nozzle is provided with a nozzle, the rear end is provided with an insertion hole, and a ring-shaped boss is provided on the outer wall. The atomizing microplate and reinforcing substrate can be disposed of into the atomizing microplate slot from the socket of the atomizing nozzle. The front end of the fixing plug is provided with a cylindrical boss, which can be inserted into the rear end hole of the atomizing nozzle to fix the atomizing micro-orifice plate and the reinforcing substrate in the atomizing micro-orifice plate groove. The outer casing of the atomizer is provided with a through hole, and the front end of the inner wall is provided with a ring-shaped boss, which is fixed by being sleeved on the outside of the atomizing nozzle and the fixing plug.

Description

A precision inhalation drug nebulizer

technical field

The invention relates to a nebulizer, in particular to a precision inhalation drug nebulizer.

Background technique

With the increasingly serious air pollution, the number of patients suffering from respiratory diseases at home and abroad is increasing, and the use of respiratory system drugs has gradually entered the field of vision of pharmaceutical companies, doctors and patients. Asthma and chronic obstructive pulmonary disease (COPD) are the two most serious respiratory diseases affecting patients. In 2013, statistics from the World Health Organization showed that respiratory diseases have jumped to the third leading cause of death. disease, the mortality rate is as high as 14.09%. However, with the great development of new technologies in pulmonary inhalation drug delivery, the majority of patients also prefer to use inhalation drug delivery to treat pulmonary and bronchial diseases. Nebulized inhalation drug delivery devices are mainly divided into the following four types: MDI inhalation aerosol, dry powder drug delivery device, active nebulized solution inhalation device and precision nebulized drug delivery device. Recently, inhaled drugs with passive precision atomization drug delivery device as the main body produced by a German pharmaceutical company have been put into the market in batches, bringing about a technological revolution in inhalation drug delivery.

Passive precision drug delivery devices usually include precision atomizers, drug storage containers, dosing devices, and mechanical pressure devices. The drug solution measured by the quantitative device acts on one side of the precision atomizer through the mechanical pressure device, and then the other side sprays fine mist droplets of the drug solution. Inhalation into the respiratory system completes the targeted delivery of the drug.

In the prior art, the spray duration of traditional MDI inhalation aerosols is short, only 0.2 seconds to 0.3 seconds, and many patients with poor coordination ability cannot fully inhale; while dry powder dispensers require patients to inhale hard, and active atomization is required. The solution inhalation device is inconvenient to operate and not easy to carry; at the same time, the existing precision atomization device in Germany has high cost, complicated assembly and low production yield. The present invention has the advantages of low production cost, high efficiency, convenient installation, and easy portability. Meanwhile, compared with the traditional inhalation administration method, the present invention does not need propellants, and the spray is gentle, and the dynamic particle size of the atomized droplets is 0.5-6 microns. It is easier to penetrate into the lungs within the range of the same dose, and the injection time of the same dose of the drug solution is longer, and it has the characteristics of good therapeutic and synergistic properties.

SUMMARY OF THE INVENTION

The main purpose of the present invention is to provide a precise inhalation drug nebulizer.

In order to achieve the above purpose, the technical scheme adopted in the present invention is as follows: including an atomizing micro-plate, a reinforcing substrate and a fixing device, the atomizing micro-plate is provided with several through holes, and one end of the atomizing micro-plate is provided by feeding one end of the atomizing micro-plate. The liquid exerts pressure, and the other end shoots atomized droplets. The reinforcing substrate is used to support the atomized microplate to improve the strength. The fixing device is composed of an atomizing nozzle, a fixing plug and an atomizer jacket. The front end of the atomizing nozzle is provided with a nozzle, the rear end is provided with an insertion hole, and an annular boss is provided on the outer wall. The atomizing microplate and reinforcing substrate can be disposed of into the atomizing microplate slot from the socket of the atomizing nozzle. The front end of the fixing plug is provided with a cylindrical boss, which can be inserted into the rear end hole of the atomizing nozzle to fix the atomizing micro-orifice plate and the reinforcing substrate in the atomizing micro-orifice plate groove. The outer casing of the atomizer is provided with a through hole, and the front end of the inner wall is provided with a ring-shaped boss, which is fixed by being sleeved on the outside of the atomizing nozzle and the fixing plug.

Preferably, the atomizing microplate is made of silicon, silicon dioxide, silicon compounds or stainless steel.

Preferably, the apertures of the several through-holes of the atomization microplate are in the range of 0.5 microns to 10 microns, the number of small holes is in the range of 50 to 250,000, and the thickness of the atomization microplates is in the range of 100-1000 microns . By applying pressure to the liquid at one end of the atomized microplate, atomized droplets are ejected at the other end, and the dynamic average particle size of the atomized droplets is 0.5-6 microns.

Preferably, the diameter of the through holes of the atomization microplate is 1 micron.

Preferably, the number of penetrations of the atomization microplates is 374.

Preferably, the thickness of the atomizing microplate is 600 microns.

Preferably, the atomizing microplate is provided with a plurality of through holes, the cross section perpendicular to the through holes is polygonal or circular, and the cross-sectional area is in the range of 1-100 square millimeters.

Preferably, the cross-section of the atomizing micro-orifice plate perpendicular to the through holes is square, and the cross-sectional area thereof is 1 square millimeter.

Preferably, the reinforcing substrate is made of stainless steel or metal with strong corrosion resistance, which can be selectively used according to the strength of the atomized micro-orifice plate.

Preferably, the reinforcing base plate is made of stainless steel 316L.

Preferably, the reinforcing substrate is provided with several through holes, the diameter of the small holes on the reinforcing substrate is in the range of 1-500 microns, and the thickness of the reinforcing substrate is 100-500 microns. The cross-sectional shape of the reinforcing substrate and the atomizing microplate is the same as that of the through holes. When the reinforcing substrate and the atomizing microplate are overlapped, each small hole of the reinforcing substrate can accommodate several through holes on the atomizing microplate. small holes.

Preferably, the pore size of the reinforcing substrate is 100 microns.

Preferably, the thickness of the reinforcing substrate is 200 microns.

Preferably, the taper range of the inverted conical nozzle at the front end of the atomizing nozzle of the fixing device is 15-165 degrees.

Preferably, the taper of the inverted conical nozzle at the front end of the atomizing nozzle of the fixing device is 90 degrees.

Preferably, the outer casing of the atomizer of the fixing device is provided with a through hole, and a circular annular boss is provided along the circumferential direction at the front end of the inner wall of the hole. The rear end of the outer wall of the atomizing nozzle is provided with a circular annular boss along the circumferential direction, and the atomizing nozzle can be fixed without falling off by the nesting of the two annular bosses.

Compared with the prior art, the present invention has the following beneficial effects:

Compared with ordinary spray devices, the precision inhalation drug nebulizer has a finer spray, and the dynamic particle size of the atomized droplets is in the range of 0.5-6 microns, which is easier to penetrate into the lungs, and the spray time of the same dose of drug solution is longer. , has the characteristics of good treatment and synergy, and is easier to produce and assemble compared with similar precision atomizers, and the cost is lower.

Description of drawings

Fig. 1 is a front view according to a preferred embodiment of the present invention;

Figure 2 is a cross-sectional view according to a preferred embodiment of the present invention;

3 is a perspective view of an atomizing microplate according to a preferred embodiment of the present invention;

4 is a perspective view of a reinforcing substrate according to a preferred embodiment of the present invention;

5 is an assembly diagram of an atomizing microplate and a reinforcing substrate according to a preferred embodiment of the present invention;

6 is a perspective view of an atomizing nozzle according to a preferred embodiment of the present invention

7 is a cross-sectional view of an atomizing nozzle according to a preferred embodiment of the present invention;

Figure 8 is a perspective view of a fixing plug according to a preferred embodiment of the present invention;

Figure 9 is a perspective view of an atomizer jacket according to a preferred embodiment of the present invention;

Figure 10 is a cross-sectional view of the nebulizer housing according to a preferred embodiment of the present invention;

Detailed ways

The following description serves to disclose the invention to enable those skilled in the art to practice the invention. The preferred embodiments described below are given by way of example only, and other obvious modifications will occur to those skilled in the art.

As shown in Figures 1-10, a precision inhalation drug nebulizer includes an atomizing micro-plate 1, a reinforcing substrate 2 and a fixing device 3, and the atomizing micro-plate 1 is provided with several through holes 4. By applying pressure to the liquid at one end of the atomization microplate 1, the atomized droplets are projected at the other end. The fixing device 3 is composed of three parts: the atomizing nozzle 5 , the fixing plug 6 and the outer casing 7 of the atomizer. The front end of the atomizing nozzle 5 is provided with a nozzle 8, the rear end is provided with an insertion hole 9, and a ring-shaped boss 10 is provided along the outer wall. The atomizing micro-orifice plate 1 and the reinforcing substrate 2 can be disposed into the atomizing micro-orifice plate groove 15 from the insertion hole 9 of the atomizing nozzle 5 . The front end of the fixing plug 6 is provided with a cylindrical boss 11 , which can be inserted into the rear end hole 9 of the atomizing nozzle 5 to fix the atomizing micro-orifice plate 1 and the reinforcing substrate 2 in the atomizing micro-orifice plate groove 15 . The atomizer casing 7 is provided with a through hole 12 , and the front end of the inner wall of the atomizer casing 7 is provided with a ring-shaped boss 13 , which is fixed by being sleeved on the atomizing nozzle 5 and the fixing plug 6 .

The atomization microplate 1 is provided with 374 through holes 4. By applying pressure to the liquid at one end of the atomization microplate 1, atomized droplets can be projected at the other end. The dynamic average particle size of the droplets is 0.5-6 microns.

The reinforcing substrate 2 and the atomizing microplate 1 have the same vertical cross-sectional shape as the through holes 4, and 45 small holes 16 are arranged on the reinforcing substrate. When the reinforcing substrate 2 and the atomizing microplate 1 are overlapped and placed, Each of the small holes 16 of the reinforcing substrate 2 can accommodate several through holes 4 on the atomizing microplate 1 .

The front end of the atomizing nozzle 5 of the fixing device 3 is provided with an inverted conical nozzle 8 whose taper 17 is 90 degrees.

The atomizer jacket 7 of the fixing device 3 is provided with a through hole 12 , and a circular annular boss 13 is provided at the front end of the inner wall of the hole 12 along the circumferential direction. The rear end of the outer wall of the atomizing nozzle 5 is provided with a circular annular boss 10 along the circumferential direction.

The foregoing has shown and described the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited by the above-mentioned embodiments. The above-mentioned embodiments and descriptions describe only the principles of the present invention. Without departing from the spirit and scope of the present invention, there are various Variations and improvements are intended to fall within the scope of the claimed invention. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims (8)

1. The utility model provides a precision is inhaled atomizer of dosing, includes atomizing micropore board, reinforcing base plate and fixing device, be provided with the aperture that the several runs through on the atomizing micropore board, exert pressure through the liquid for atomizing micropore board one end, the other end jets out the atomized liquid drop. The reinforcing substrate is used for supporting the atomizing micropore plate to improve strength. The fixing device consists of an atomizing nozzle, a fixing plug and an atomizer outer sleeve. The front end of the atomizing nozzle is provided with a nozzle, the rear end of the atomizing nozzle is provided with a jack, and the outer wall of the atomizing nozzle is provided with a circle of annular bosses. The atomizing micropore plate and the reinforcing substrate can be arranged into the atomizing micropore plate groove from the jack of the atomizing nozzle. The front end of the fixing plug is provided with a cylindrical boss, and the atomizing microporous plate and the reinforcing substrate can be fixed in the atomizing microporous plate groove by inserting into a rear-end jack of the atomizing nozzle. The atomizer overcoat is provided with the jack that runs through, and the inner wall front end is provided with the cyclic annular boss, accomplishes fixedly through the cover outside atomizer and the fixed stopper.

2. The nebulizer of claim 1, wherein the micro-porous plate is made of silicon, silicon dioxide, silicon compound or stainless steel.

3. The nebulizer of claim 1, wherein the aperture of the plurality of through holes of the nebulizing micro-porous plate ranges from 0.5 micron to 10 microns, the number of the micro-holes ranges from 50 to 25 ten thousand, and the thickness of the nebulizing micro-porous plate ranges from 100 microns to 1000 microns. The liquid at one end of the atomization microporous plate is pressurized, and atomized liquid drops are thrown at the other end of the atomization microporous plate, wherein the dynamic average particle size of the atomized liquid drops is 0.5-6 microns.

4. The precise atomizer for inhalation and drug delivery of claim 1, wherein the atomizing porous plate is provided with a plurality of small holes therethrough, the cross section perpendicular to the small holes is polygonal or circular, and the cross-sectional area ranges from 1 to 100 square millimeters.

5. The nebulizer of claim 1, wherein the reinforcing base plate is made of stainless steel or a metal with high corrosion resistance. Can be selectively used according to the strength of the atomized microplate.

6. The nebulizer of claim 1, wherein the reinforcing substrate has a plurality of holes therethrough, the holes of the reinforcing substrate have a diameter ranging from 1 to 500 μm, and the thickness of the reinforcing substrate is 100-500 μm. Strengthen the base plate and the atomizing micropore board with run through the aperture vertically cross sectional shape unanimously, strengthen the base plate and overlap with the atomizing micropore board and when placing, can hold the aperture that runs through on the several atomizing micropore board in every aperture of reinforcing the base plate.

7. A nebulizer for precise inhalation and drug delivery according to claim 1, wherein the nozzle opening at the front end of the nebulizer head of the fixing device is in the shape of an inverted cone with a taper angle in the range of 15-165 °.

8. The precise inhalation and drug delivery atomizer according to claim 1, wherein the atomizer outer sleeve of the fixing device is provided with a through hole, and a ring-shaped boss is arranged at the front end of the inner wall of the hole along the circumferential direction. The rear end of the outer wall of the atomizing nozzle is provided with a circle of circular ring-shaped bosses along the circumferential direction, and the atomizing nozzle can be fixed and cannot fall off through nesting of the two circular ring-shaped bosses.

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