CN114711432A - Water-soluble calcium and preparation method thereof, calcium agent and application of water-soluble calcium - Google Patents
Water-soluble calcium and preparation method thereof, calcium agent and application of water-soluble calcium Download PDFInfo
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- 239000011575 calcium Substances 0.000 title claims abstract description 259
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 226
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 203
- 238000002360 preparation method Methods 0.000 title claims abstract description 34
- 239000003795 chemical substances by application Substances 0.000 title description 9
- 229960005069 calcium Drugs 0.000 claims abstract description 212
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims abstract description 41
- 235000019691 monocalcium phosphate Nutrition 0.000 claims abstract description 41
- 238000002156 mixing Methods 0.000 claims abstract description 29
- 239000000203 mixture Substances 0.000 claims abstract description 29
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 26
- OWFJMGQSOHDIPP-UHFFFAOYSA-L monocalcium citrate Chemical compound [Ca+2].OC(=O)CC(O)(C(O)=O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC([O-])=O OWFJMGQSOHDIPP-UHFFFAOYSA-L 0.000 claims abstract description 25
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 25
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 23
- 239000002253 acid Substances 0.000 claims abstract description 11
- 230000002378 acidificating effect Effects 0.000 claims abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 6
- 206010006956 Calcium deficiency Diseases 0.000 claims abstract description 5
- 235000013361 beverage Nutrition 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 80
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 229910001868 water Inorganic materials 0.000 claims description 48
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 28
- 239000001506 calcium phosphate Substances 0.000 claims description 19
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 17
- 239000000292 calcium oxide Substances 0.000 claims description 16
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 claims description 16
- 239000001354 calcium citrate Substances 0.000 claims description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 14
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 11
- 239000000920 calcium hydroxide Substances 0.000 claims description 11
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 11
- 235000012663 monocalcium citrate Nutrition 0.000 claims description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 230000032683 aging Effects 0.000 claims description 4
- 235000020510 functional beverage Nutrition 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 229940043430 calcium compound Drugs 0.000 claims description 2
- 150000001674 calcium compounds Chemical class 0.000 claims description 2
- 150000002484 inorganic compounds Chemical class 0.000 claims description 2
- 229910010272 inorganic material Inorganic materials 0.000 claims description 2
- HZRIQKYKFIEQBO-UHFFFAOYSA-J dicalcium hydrogen carbonate 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound C([O-])([O-])=O.[Ca+2].C(CC(O)(C(=O)O)CC(=O)[O-])(=O)[O-].[Ca+2] HZRIQKYKFIEQBO-UHFFFAOYSA-J 0.000 claims 1
- 229940069978 calcium supplement Drugs 0.000 abstract description 16
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract description 12
- 210000004211 gastric acid Anatomy 0.000 abstract description 12
- 239000011574 phosphorus Substances 0.000 abstract description 12
- 239000013589 supplement Substances 0.000 abstract description 9
- 239000002552 dosage form Substances 0.000 abstract description 8
- 208000037157 Azotemia Diseases 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003792 electrolyte Substances 0.000 abstract description 3
- 238000001631 haemodialysis Methods 0.000 abstract description 3
- 230000000322 hemodialysis Effects 0.000 abstract description 3
- 208000009852 uremia Diseases 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 2
- CPGKMLVTFNUAHL-UHFFFAOYSA-N [Ca].[Ca] Chemical compound [Ca].[Ca] CPGKMLVTFNUAHL-UHFFFAOYSA-N 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 62
- 229910000019 calcium carbonate Inorganic materials 0.000 description 31
- 229960003563 calcium carbonate Drugs 0.000 description 31
- 229960004106 citric acid Drugs 0.000 description 16
- 238000010521 absorption reaction Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 239000000463 material Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 11
- 241000700159 Rattus Species 0.000 description 9
- 235000011116 calcium hydroxide Nutrition 0.000 description 9
- 238000001035 drying Methods 0.000 description 9
- 238000012360 testing method Methods 0.000 description 8
- 229960004543 anhydrous citric acid Drugs 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- -1 hydrogen ions Chemical class 0.000 description 7
- 230000001502 supplementing effect Effects 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 239000008267 milk Substances 0.000 description 6
- 210000004080 milk Anatomy 0.000 description 6
- 235000013336 milk Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 5
- 210000002249 digestive system Anatomy 0.000 description 5
- 238000005507 spraying Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 235000013337 tricalcium citrate Nutrition 0.000 description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 229910052573 porcelain Inorganic materials 0.000 description 4
- 210000000689 upper leg Anatomy 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000037182 bone density Effects 0.000 description 3
- 229940095643 calcium hydroxide Drugs 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 230000002124 endocrine Effects 0.000 description 3
- 239000012065 filter cake Substances 0.000 description 3
- 235000012631 food intake Nutrition 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 229960001714 calcium phosphate Drugs 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010015719 Exsanguination Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 235000021068 Western diet Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000021191 food habits Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/38—Other non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention relates to the fields of biological health care and medicine, and discloses water-soluble calcium, a preparation method thereof, a calcium preparation and application of the water-soluble calcium. A method for preparing water-soluble calcium comprising: and fully mixing the combined fixed calcium and the combined acid for reaction to obtain water-soluble calcium, wherein the water-soluble calcium consists of at least one of acidic calcium dihydrogen citrate and acidic calcium dihydrogen phosphate. Preferably, the water-soluble calcium-calcium mixture is characterized in that the mass ratio of calcium to phosphorus is Ca, P is 2: X (0 is less than or equal to X and less than 1). On the basis of keeping the proportion of calcium at 2, the phosphorus is adjusted between 0 and 1 to meet the requirements of people who supplement calcium on phosphorus, such as patients of different ages, patients with stable electrolytes caused by calcium loss due to diseases or sports, patients with uremia and hemodialysis, and the like. The water-soluble mixed calcium does not occupy or occupies little gastric acid for biological calcium supplement, and can be directly absorbed by organisms. The water-soluble calcium provided by the application can be prepared into various dosage forms, and can be applied to beverages and medicines for treating calcium deficiency diseases.
Description
Technical Field
The invention relates to the fields of biological health products and medicines, in particular to water-soluble calcium, a preparation method thereof, a calcium preparation and application of the water-soluble calcium.
Background
It is known that Ca is a natural product which cannot be synthesized. Ca needed by animals and human can only be absorbed and supplemented by food, and Ca element supplement of human body is that Ca contained in food is decomposed into free Ca by gastric acid and absorbed by large intestine and small intestine. The human body gastric acid is a natural function of the organism body for maintaining life, and meets the requirement of the digestion function required by the human body natural food intake, if the amount of the gastric acid required by the food intake exceeds the amount of the human body natural gastric acid without other gastric acid food increasing auxiliary conditions, the digestive system of the human body can generate adverse digestion reaction, inappetence, even constipation and stomachache.
Ca is one of essential elements of human bodies, accounts for 1.5-2.0% of the weight of the human bodies, is the peak period of Ca source absorption of the human bodies from 6 months to 35 years old, and is more required by women than men due to physiological reasons. The Ca source of the human body is mainly obtained from food, but the calcium obtained from the food by the human body due to regional food and dietary habit difference is different, for example, the milk product in western diet is more, the Ca source absorption is better than that of Asian, and the milk calcium in the milk product is water-soluble calcium and is easy to absorb; most Asian foods are grains, the absorption of Ca source is poor, and the requirement of Ca supplement is large. At present, the traditional Ca source supplement in China is mainly calcium carbonate, and calcium lactate, calcium gluconate and the like exist, the calcium belongs to fixed calcium which cannot be dissolved in water and can not be directly absorbed by a human body, the fixed calcium can be absorbed by the human body only by changing into free calcium through decomposition of gastric acid, and the free calcium is water-soluble.
Because water-soluble calcium is easy to be absorbed by human bodies, people advocate to drink milk for supplementing calcium and protein, but the calcium content in milk is not high, and some high-calcium drinks and milk powder are also artificially added with some fixed calcium to improve the calcium content, but the fixed calcium is insoluble in water, and compared with soluble calcium, the absorption effect is not good.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention aims to provide water-soluble calcium, a preparation method thereof, a calcium agent and application of the water-soluble calcium.
In a first aspect, an embodiment of the present application provides a method for preparing water-soluble calcium, including:
fully mixing the combined fixed calcium with combined acid for reaction to obtain water-soluble calcium, wherein the water-soluble calcium consists of at least one of acidic calcium dihydrogen citrate and acidic calcium dihydrogen phosphate; the water-soluble calcium obtained by fully mixing and reacting the combined fixed calcium with the combined acid is as follows:
when the water-soluble calcium is calcium dihydrogen citrate, the preparation method comprises mixing citric acid and calcium fixed citrate at a ratio of not less than 2, adding water, mixing, and aging;
when the water-soluble calcium is calcium dihydrogen phosphate, the preparation method comprises mixing inorganic calcium compound and phosphoric acid at a mass ratio of CaO/P2O5Mixing and curing the components according to the ratio of 0.35-0.56;
when the water soluble calcium is a mixture of calcium dihydrogen citrate and calcium dihydrogen phosphate, the preparation method comprises mixing and aging citric acid, calcium hydroxide and calcium dihydrogen phosphate at a mass ratio of 4:1: 1.5-1.7; or mixing the separately prepared monocalcium citrate and monocalcium phosphate.
In an alternative embodiment, when the water-soluble calcium is acidic monocalcium citrate, the ratio of citric acid to citric acid fixed calcium is 2.1.
In an alternative embodiment, the inorganic compound calcium is present in a mass ratio CaO/P with phosphoric acid2O5The ratio of 0.4-0.5, and mixing and curing.
In an alternative embodiment, CaO/P2O5＝0.48。
In an alternative embodiment, when the water-soluble calcium is a mixture of calcium dihydrogen citrate and calcium dihydrogen phosphate, the water-soluble calcium is prepared by mixing and aging citric acid, calcium hydroxide and calcium dihydrogen phosphate according to a mass ratio of 4:1: 1.58.
In a second aspect, the present application provides a water-soluble calcium prepared by the preparation method provided in any one of the above embodiments.
In a third aspect, the present invention provides a calcium preparation, including the above water-soluble calcium, wherein Ca: P ═ 2: X (X ═ 0 to 1).
In alternative embodiments, the calcium agent is a granule, tablet or oral liquid.
In a fourth aspect, the present application provides a solid beverage, which includes the above water-soluble calcium.
In a fifth aspect, the present application provides a functional beverage, which includes the above water-soluble calcium.
In a sixth aspect, embodiments of the present application provide a medicament for treating calcium deficiency disorders, comprising the above-described water-soluble calcium.
The invention has the following beneficial effects:
the method for preparing water-soluble calcium provided by the application enables excessive acid to react with fixed calcium to generate monocalcium phosphate and/or monocalcium citrate (monocalcium citrate) with appropriate acidity and free hydrogen ions. When free hydrogen ions are contained in the calcium dihydrogen phosphate and the calcium dihydrogen citrate, the hydrophilicity of the calcium dihydrogen phosphate and the calcium dihydrogen citrate is enhanced, so that the prepared water-soluble calcium can be dissolved in water solution and becomes free calcium ions which can be directly absorbed by organisms.
The water-soluble calcium or the water-soluble mixed calcium provided by the application ensures that the proportion of the calcium is 2, and the phosphorus is adjusted between 0 and 1 so as to adapt to the requirements of calcium-supplementing people, such as stable electrolytes generated by calcium loss caused by diseases or sports, uremia and hemodialysis patients and the like. The water-soluble mixed calcium does not occupy or occupies little gastric acid for biological calcium supplement, and can be directly absorbed by organisms. Compared with the absorption performance of calcium carbonate, the calcium carbonate can supplement calcium only by 50 percent of the mass of the calcium carbonate. Has no adverse reaction after calcium carbonate is taken.
The water-soluble mixed calcium is a novel supplement of element calcium, has excellent calcium supplementing performance, enables calcium to be supplemented conveniently and rapidly, and can be prepared into tablets, granules, solid or functional beverages, oral liquid health-care foods and the like. If necessary, the calcium deficiency disease can be treated by the preparation method.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic diagram of a biological test process for verifying the effectiveness of the product of the present technology after biological ingestion.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The water-soluble calcium and the preparation method thereof, the calcium agent and the application of the water-soluble calcium are provided in the following.
The preparation principle and the method of the water-soluble calcium provided by the invention are as follows:
the principle of the technology is that excessive hydrogen ions are added in a compound by using a technical means by some alkali metal organic or inorganic salts which can not be dissolved in water, so that the molecular structure of the compound substance is unstable, a hydrophilic free structure is formed, and the aim of easy absorption in a biological intake digestive system is fulfilled.
The preparation method of the water-soluble calcium can be divided into the following methods:
first, the first:
when the water-soluble calcium is acidic calcium dihydrogen citrate, the preparation method comprises the following steps:
the citric acid and citric acid fixed calcium are mixed and aged according to the ratio of more than or equal to 2.
Specific examples thereof include: taking 100g of conventional food-grade citric acid fixed calcium, mixing according to the ratio of citric acid to citric acid fixed calcium being more than or equal to 2, and adding water, wherein the larger the multiple is, the lower the mass content of Ca in water soluble is, and the higher the mass content is otherwise.
The preferred ratio is 2 or 2.1.
More specifically, the preparation method comprises the following steps:
according to the ratio of citric acid to citric acid fixed calcium being 2.1, 210g of anhydrous citric acid is mixed with 100g of food-grade citric acid fixed calcium, after uniform mixing,adding water accounting for 5-9% of the total weight of the mixture into the mixture, adding water in a mist form, spraying while stirring uniformly, wherein the water addition amount is preferably uniform according to the wetting of the mixture, the curing time of the mixture is enabled to be at least more than 2 hours, drying in an oven at 80-115 ℃, and controlling the water content to be less than 0.5% after drying. The obtained water-soluble calcium citrate has Ca content of 7%, and water solubility of 2g/100ml H2O。
And the second method comprises the following steps:
when the water-soluble calcium is monocalcium phosphate, the preparation method comprises the following steps:
the preparation method of water-soluble calcium phosphate depends on calcium-containing raw material, the raw material can be formed by adding phosphoric acid into any one of calcium phosphate, calcium hydrogen phosphate or calcium dihydrogen phosphate, or calcium carbonate and calcium hydroxide, but the key points are that the mass ratio of calcium oxide to phosphorus pentoxide is controlled, and CaO/P2O50.35-0.56, the higher the ratio, the lower the water-soluble free calcium content. The higher the ratio, the lower the water-soluble free calcium content.
Preferred CaO/P2O5＝0.4～0.5；
More preferably CaO/P2O5＝0.48；
When CaO/P is present2O5When the concentration is 0.48, the water content is about 2g/100ml H2O when CaO/P is2O5When the concentration is 0.35, the water content is about 9g/100ml H2O。
And the third is that:
the water soluble calcium is a mixture of calcium dihydrogen citrate and calcium dihydrogen phosphate.
The preparation method comprises two steps:
(1) food-grade anhydrous citric acid, food-grade calcium hydroxide and food-grade calcium dihydrogen phosphate are mixed and reacted. The mixing ratio is 4:1: 1.5-1.7.
The preferred mixing ratio is 4:1: 1.5-1.7;
more preferably the mixing ratio is 4:1: 1.58.
Taking the ratio of 4:1:1.58, fixing 31.5g of calcium by using 80g of food-grade anhydrous citric acid, 20g of food-grade calcium hydroxide and conventional food-grade monocalcium phosphate, uniformly mixing, and then mixingAnhydrous citric acid is used for fixing 25% of the total weight of calcium, calcium hydroxide and calcium dihydrogen phosphate, water is added, the mixture is uniformly stirred while being sprayed, and after the mixture is aged for hours, the mixture is dried in an oven at the temperature of 80-115 ℃, and the water content after the drying is less than 0.5%. The obtained water-soluble calcium citrate has pH of 3.65, Ca of 11.54%, P of 5.85, and water solubility of 2.2g/100ml H2O。
(2) The acid monocalcium citrate and the acid monocalcium phosphate are prepared separately according to the above-described first method and second method, and then mixed.
The calcium preparation provided by the embodiment of the invention comprises the water-soluble calcium as described in the previous embodiment, which contains calcium dihydrogen phosphate with free hydrogen ions and calcium dihydrogen citrate with free hydrogen ions, and the ratio of the mass of calcium to the mass of phosphorus is 2: P (X is 0-1, X is not equal to 0) in consideration of the requirements of different groups of biological calcium supplement, such as age and sex and the condition of limitation on P.
In the above recommended dosage forms, when X is 0, the dosage form is equivalent to the product of the first preparation method and the product of water-soluble calcium citrate, and the water-soluble calcium citrate is characterized by containing no phosphorus and P is 0, and the product has the advantage of being suitable for calcium supplement crowds who are prohibited from or controlled from phosphorus, uremia, hemodialysis patients and the like.
In the general proportion of the recommended dosage form, when X is more than 0 and less than 1, the calcium supplement is a calcium supplement crowd who solves the problems of electrolyte stability and disturbance caused by calcium loss caused by diseases or sports and needs to control phosphorus in calcium supplement.
According to the ratio of the alkali metal elements Ca and P required by normal adults of organisms, the Ca and P elements are directly formed or matched to form a Ca and P element ratio of 2:1, namely the Ca: P-2: 1 dosage form. The starting point of the preparation is that people who supplement calcium are treated according to the conventional method. The dosage is only 1/2 calcium carbonate dosage, and the experimental result index of the soluble calcium basically achieves the calcium supplement effect of the calcium carbonate. The maximum Ca requirement of human adult is 0.8g per day.
The above methods can prepare water soluble calcium, and the third method can prepare water soluble mixed calcium with water solubility of 2.0g/100ml H2And (O). However, the third method is for preparing the calcium dosage form of Ca: P ═ 2:1The process presented by the method (1) is simple and has high efficiency.
The water-soluble mixed calcium obtained by the third method, wherein the ratio of Ca and P elements is 2:1, is subjected to biological tests to verify the effect of calcium carbonate after biological intake, which is equivalent to that of calcium carbonate currently used in the market. Detailed as example 6.
Further, the calcium agent provided by the application can be tablets, granules or oral liquid.
Further, the water-soluble calcium provided by the application can be applied to various beverages, such as solid beverages or functional beverages, or can be applied to preparation of medicines for treating calcium deficiency diseases.
The water-soluble calcium prepared by the method does not occupy gastric acid or occupies a very small amount of gastric acid, so that the body keeps a normal endocrine digestive system, and the side effect caused by calcium supplement by calcium carbonate is avoided. The water-soluble calcium provided by the application is used for supplementing calcium, and is beneficial to the height of organisms and is increased. Livestock and poultry can increase body size and yield, and human can increase average height. The calcium agent provided by the application is a dosage form which is comprehensively effective in calcium supplement and absorption, and is a novel calcium source for efficiently supplementing calcium. The water-soluble calcium provided by the application is matched with VD for use in practical application, the effect is very obvious, and if xylose pure or water-soluble magnesium, potassium and zinc are added, the effect is better.
The present application will be described below with reference to specific examples.
Example 1
Taking 50g of conventional food-grade citric acid fixed calcium, taking 105g of anhydrous citric acid according to 2.1 times of the weight of the citric acid fixed calcium, uniformly mixing the anhydrous citric acid and the mixture in a porcelain dish, adding 6g of water into the mixture, spraying the water in a mist form by using a hand-held sprayer, uniformly stirring while spraying, covering the porcelain dish with a PE film after the mixture is uniformly wetted, curing the mixture for 2 hours, and drying in an oven at the constant temperature of 100 ℃ for 2 hours to obtain the water-soluble calcium citrate, wherein the water content is 0.35 percent. Ca 7.12%, water solubility 2.12g/100ml h2O。
Example 2
Get usualThe calcium hydroxide with the content of CaO being 95 percent is put into a 500ml beaker, 221g is taken, and the process water is added to prepare 55 percent aqueous solution. Taking CaO/P2O5Slowly adding 700g of 75 percent phosphoric acid while stirring to form a neutralization solution, continuously stirring for 2 hours, pouring the neutralization solution into a 500-mesh 600-mesh filter bag after the complete reaction is finished, placing the filter bag in a centrifuge, drying the filter bag at the rotating speed of the centrifuge to 3000 revolutions, starting the centrifuge, and separating the filter bag in 8-10 minutes to obtain the water-soluble monocalcium phosphate filter cake. Putting the filter cake in a ceramic plate, manually kneading the filter cake to be loose as much as possible, putting the ceramic plate in a drying box with a set constant temperature of 185 ℃, and drying at the constant temperature. If the dried product is burned for 30 minutes at 800 +/-25 ℃, the burning loss is less than or equal to 14 percent, and the obtained product is anhydrous water-soluble calcium dihydrogen phosphate; the ignition decrement is less than or equal to 17 percent, and the obtained product is water-soluble monocalcium phosphate. The water soluble calcium dihydrogen phosphate obtained by the method has the dry basis that Ca is 15.77 percent and P is 17.66 percent, and the dissolution amount in water is 3.75.0g/100ml H2O。
Example 3
100g of conventional anhydrous food-grade monocalcium phosphate is placed in a porcelain dish, wherein the food-grade monocalcium phosphate comprises 15.22 percent of Ca and 53.5 percent of P2O 5. Taking CaO/P2O50.38, 4.5g of 85% phosphoric acid was diluted to 50% acid. Spraying 50% acid on calcium dihydrogen phosphate with a hand-held sprayer in a mist manner, uniformly stirring while spraying, covering a porcelain dish with a PE film after the mixture is uniformly wetted, curing the mixture for 2 hours, and drying in an oven at 100 ℃ for 2 hours at constant temperature to obtain water-soluble calcium dihydrogen phosphate, and testing results: and 0.55 percent of water. 15.22% of Ca, 31.6% of P and 8.9g/100ml of H dissolved in water2O。
This example demonstrates that in preparing water soluble monocalcium phosphate, when CaO/P is present2O5The lower the content of the water-soluble free calcium ion component in the obtained water-soluble calcium substance is, the higher the amount of the free calcium ion component dissolved in water is
Example 4
Taking 2.2 parts of the material in the example 1, and taking 0.8 part of the material in the example 2, wherein each part is 100g, the material in the example 1 is 220g, and the mass content of Ca in 220g of the material in the example 1 is 15.7g instead of 220gx7.12 percent; example 2 material 80g, the mass content of Ca in 80g of example 2 material 15.77x 0.8% ═ 12.6g, the mass content of phosphorus P in 80g of example 2 material was: 17.66 × 0.8% ═ 14.1 g; the total weight of the three materials is 300g after being uniformly mixed, and the mass content of Ca in 300g of the water-soluble calcium mixture is 15.7g +12.6 g-28.3 g; in 300g of mixture water-soluble calcium, the mass content of phosphorus P is 14.1g to 300g of mixture water-soluble calcium, and the ratio of Ca and P elements reaches a mass ratio of about 2:1, namely 28.3: 14.1: 2: 1.
Example 5
80g of food-grade anhydrous citric acid, 20g of food-grade calcium hydroxide and 31.5g of conventional food-grade monocalcium phosphate fixed calcium are used for uniformly mixing, then water is added according to 25 percent of the total weight of the food-grade anhydrous citric acid fixed calcium, the calcium hydroxide and the monocalcium phosphate, the mixture is uniformly stirred while being sprayed, and after the mixture is cured for hours, the mixture is dried in an oven at the temperature of 80-115 ℃, and the water content after the drying is less than 0.5 percent. The obtained mixture water-soluble calcium has pH of 3.65, Ca of 11.54%, P of 5.85, and water solubility of 2.2g/100ml H2The mass content ratio of the elements of O, Ca and P reaches a mass ratio of approximately equal to 2:1, namely, the mass ratio of Ca to P is 11.54:5.85 to 1.97: 1.
Example 6
The absorption effect of the dosage form prepared by the technology and the recommended mass ratio of calcium to phosphorus is 1.8-2.2: 1 in organisms is verified, and the results are as follows:
1. protocol (see figure 1 for details):
1.1 test samples
Disclosed is water-soluble calcium mixture. Calcium phosphorus Ca P2: 1. Wherein, the content of Ca is 25.0 percent, and the content of P is 12.5 percent;
and calcium carbonate. Wherein, the content of Ca is 40.0 percent.
1.2 Experimental animals
1.2.1 animal feeding
60 healthy male SD rats of clean grade (weaning) were born for about 4 weeks, 60-80g, and divided into 5 groups of 10 animals by body weight. The low-calcium feed is prepared according to technical specifications for health food inspection and evaluation (2003 edition). According to the content of calcium in the experimental sample, 5 times of the recommended amount of a human body is taken as one dosage group, two dosage groups are arranged, and a calcium carbonate dosage group with the same level as the high-dosage calcium is established. Rats in each group received low calcium feed (150mg/100g feed) and water was allowed to drink freely (deionized water to avoid calcium pickup from the water). After 4 weeks, the animals were anesthetized with sodium pentobarbital, sacrificed by exsanguination of the abdominal aorta, and each bone to be tested was taken for measurement.
1.2.2 animal groups
The test was divided into five groups:
wherein:
group 1: a low calcium feed group;
group 2: a water-soluble mixed calcium sample low-dose group, and the low-dose sample is administered by gavage on the basis of a low-calcium feed group;
group 3: a middle dose group of the water-soluble mixed calcium sample is used for intragastric administration of the middle dose sample on the basis of a low-calcium feed group;
group 4: a water-soluble mixed calcium sample high-dose group, and a high-dose sample is administered by intragastric gavage on the basis of a low-calcium feed group;
group 5: calcium carbonate high dose group, on the basis of low calcium feed group, calcium carbonate is administered by intragastric administration;
TABLE 1 Experimental groups
| Group of | Animal number (only) | Feed (g/kg. bw) | Water soluble calcium (g/kg. bw) | Calcium carbonate (g/kg. bw) |
| Group 1 | 10 | Low-calcium material | / | / |
| Group 2 | 10 | Low-calcium material | Is low in | / |
| Group 3 | 10 | Low-calcium material | In | / |
| Group 4 | 10 | Low-calcium material | Height of | / |
| Group 5 | 10 | Low-calcium material | / | Height of |
1.2.3 Experimental technical route
The specific technical route is shown in figure 1.
2. Study of free calcium absorption test
The experimental protocol is shown in table 2:
TABLE 2 feeding amount of each group
3. Results of the experiment
3.1 body weight
TABLE 3 weight status of mice in each group
3.2 body length
TABLE 4 body length of mice in each group
| Group of | Body length (cm, initial, n ═ 10) | Body length (cm, eighth week, n ═ 10) |
| Low-calcium feed | 13.27±0.26 | 20.52±0.21 |
| Low dose soluble calcium | 13.11±0.53 | 21.13±0.31 |
| Soluble calcium in medium dosage | 13.15±0.53 | 21.50±0.32 |
| High dose soluble calcium | 13.26±0.34 | 21.83±0.44 |
| Calcium carbonate | 13.20±0.28 | 21.28±0.41 |
3.3 femur Length
TABLE 5 femoral Length in groups of mice
| Group of | Femur length (mm, eighth week, n ═ 5) |
| Low-calcium feed | 32.55±0.78 |
| Low dose soluble calcium | 32.79±0.34 |
| Soluble calcium in medium dosage | 33.20±0.54 |
| High dose soluble calcium | 33.65±0.30 |
| Calcium carbonate | 32.71±0.70 |
3.4 bone Density
TABLE 6 bone Density in groups of mice
3.5 bone calcium content
TABLE 7 bone calcium content in mice of each group
4. Conclusion of experimental results:
from the experimental results it appears that:
in summary, the method for preparing water-soluble calcium provided in the embodiments of the present application allows excess acid to react with the fixed calcium to form monocalcium phosphate (i.e., monocalcium phosphate) and/or monocalcium citrate (monocalcium citrate) with free hydrogen ions. When free hydrogen ions are contained in the calcium dihydrogen phosphate and the calcium dihydrogen citrate, the hydrophilicity of the calcium dihydrogen phosphate and the calcium dihydrogen citrate is enhanced, so that the prepared water-soluble calcium can be dissolved in water, and the conversion from fixed calcium to water-soluble calcium is realized.
Generally, all indexes of the water-soluble calcium in biological tests are excellent calcium carbonate, the dosage of the water-soluble calcium only uses the dosage of 1/2 calcium carbonate, and the experimental result index of the soluble calcium basically reaches the calcium supplement effect of the calcium carbonate, so that the efficiency is very high by using the soluble calcium provided by the application to supplement the calcium, and the calcium-soluble calcium is a novel calcium supplement source.
The body weight of the white rats is mainly determined by the food intake, and as can be seen from table 3, the white rats fed with water-soluble calcium have the same quality as calcium carbonate, and the body weight of the white rats fed with water-soluble calcium is increased by 3.35% compared with the body weight of the white rats fed with calcium carbonate, which indicates that the body does not occupy gastric acid or occupies a very small amount of gastric acid when calcium is supplemented with water-soluble calcium, so that the body maintains a normal endocrine digestive system, no side effect is caused by calcium supplementation with calcium carbonate, and the body weight and the body length are normally grown and improved.
As can be seen from tables 4 and 5, the growth of the same organisms using calcium carbonate was achieved in white rats using a water-soluble calcium, the body length (height) and the increase rate of femur length of the white rats using only 50% of the Ca content of calcium carbonate. The water soluble calcium can supplement calcium, and is helpful for the height of organism and increase. Livestock and poultry can increase body size and yield, and human can increase average height.
As can be seen from tables 6 and 7, the same contents as those of calcium carbonate were obtained by using only 50% of the Ca mass of calcium carbonate, and the bone density and bone calcium content of rats.
The test results show that the absorption effect of the mixed water-soluble calcium produced by the technology as a calcium supplement agent is superior to that of calcium carbonate under the condition of the same using amount, and even the using amount is only 50 percent, the calcium supplement effect of calcium carbonate is achieved. The water soluble calcium is used for supplementing calcium, so that the side effect caused by using calcium carbonate can not be generated, the functions of biological endocrine and digestive system can be effectively improved, and the water soluble calcium has the advantages of especially increasing the body length (height) and the femur length. Meanwhile, the preparation formulation of Ca, P2: 1 is adopted for biological calcium supplement, is a preparation formulation which is comprehensively effective in calcium supplement and absorption, and is a novel calcium source for efficiently supplementing calcium. If the water-soluble calcium and the calcium agent provided by the application are used in the optimal calcium supplementing period of organisms, the calcium source requirement of the body in the growth period can be ensured, the calcium source enrichment can be enhanced, and the calcium loss in the old can be effectively prevented.
In view of the improvement in the absorption rate of calcium, calcium is used in combination with Vd to promote the absorption rate. The experiment only adopts Ca, P is 2:1, the effect is very obvious when the Ca, P and P are matched according to the required ratio of biological calcium to phosphorus, and if Vd is added, the effect of xylose pure or magnesium, potassium and zinc is better.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method for preparing water-soluble calcium is characterized by comprising the following steps:
fully mixing the combined fixed calcium with combined acid for reaction to obtain water-soluble calcium, wherein the water-soluble calcium consists of at least one of acidic calcium dihydrogen citrate and acidic calcium dihydrogen phosphate; the water-soluble calcium obtained by fully mixing and reacting the combined fixed calcium with the combined acid is as follows:
when the water-soluble calcium is monocalcium citrate, the preparation method comprises the steps of mixing citric acid with citric acid fixed calcium according to the ratio of more than or equal to 2, adding water, mixing and curing to obtain the calcium citrate calcium carbonate;
when the water-soluble calcium is calcium dihydrogen phosphate, the preparation method comprises mixing inorganic calcium compound and phosphoric acid at a mass ratio of CaO/P2O5Mixing and curing the components according to the ratio of 0.35-0.56;
when the water-soluble calcium is a mixture of monocalcium citrate and monocalcium phosphate, the preparation method comprises mixing and curing citric acid, calcium hydroxide and monocalcium phosphate according to the mass ratio of 4:1: 1.5-1.7; or mixing the separately prepared monocalcium citrate and monocalcium phosphate.
2. The method for preparing water-soluble calcium according to claim 1, wherein when the water-soluble calcium is calcium dihydrogen citrate, the ratio of citric acid to citric acid fixed calcium is 2.1.
3. The method for preparing water-soluble calcium according to claim 1, wherein the inorganic compound calcium is added to the phosphoric acid in a mass ratio of CaO/P2O5Mixing and curing the components according to the ratio of 0.4-0.5;
preferably, CaO/P2O5＝0.48。
4. The method for preparing water-soluble calcium according to claim 1, wherein when the water-soluble calcium is a mixture of calcium dihydrogen citrate and calcium dihydrogen phosphate, the water-soluble calcium is prepared by mixing and aging citric acid, calcium hydroxide and calcium dihydrogen phosphate in a mass ratio of 4:1: 1.58.
5. A water-soluble calcium, characterized by being prepared by the preparation method of any one of claims 1 to 4.
6. A calcium preparation comprising the water-soluble calcium of claim 5, wherein Ca, P, 2 and X (X, 0 to 1) are contained.
7. The calcium preparation according to claim 6, wherein the calcium preparation is a granule, a tablet or an oral liquid.
8. A solid beverage comprising the water-soluble calcium of claim 5.
9. A functional beverage comprising the water-soluble calcium according to claim 5.
10. A medicament for the treatment of calcium deficiency disorders comprising the water-soluble calcium of claim 5.
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