CN114797174B - Extraction column placement device - Google Patents
Extraction column placement device Download PDFInfo
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- CN114797174B CN114797174B CN202210519095.2A CN202210519095A CN114797174B CN 114797174 B CN114797174 B CN 114797174B CN 202210519095 A CN202210519095 A CN 202210519095A CN 114797174 B CN114797174 B CN 114797174B
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- column
- liquid adding
- pull rod
- liquid
- plug
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Extraction Or Liquid Replacement (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
本发明提供一种萃取柱放置装置，具有移动柱架、位于移动柱架上方的滑柱压板、固定于移动柱架下方的拉杆托板、以及两端分别固定在移动柱架和拉杆托板上的加液柱；所述加液柱的出口端安装有滴液塞，所述滴液塞具有常态下保持密封的线形缝隙，所述滴液塞还设有能够使线形缝隙打开的径向凸缘，所述径向凸缘的下侧与所述拉杆托板对应接触；所述加液柱的入口端通过密封元件与所述滑柱压板的下侧密封连接，所述滑柱压板能够受控地向下施力于所述加液柱的入口端，使加液柱的出口端的滴液塞的径向凸缘与拉杆托板之间产生相对运动趋势。本申请可迅速切换所有加液柱的出口端的密封与流通状态，无交叉污染问题。
The present invention provides an extraction column placement device, which comprises a movable column frame, a sliding column pressure plate located above the movable column frame, a pull rod support plate fixed below the movable column frame, and a liquid adding column whose two ends are respectively fixed on the movable column frame and the pull rod support plate; a dripping plug is installed at the outlet end of the liquid adding column, the dripping plug has a linear gap that is kept sealed under normal conditions, and the dripping plug is also provided with a radial flange that can open the linear gap, and the lower side of the radial flange is in corresponding contact with the pull rod support plate; the inlet end of the liquid adding column is sealed and connected to the lower side of the sliding column pressure plate through a sealing element, and the sliding column pressure plate can controllably apply force downward to the inlet end of the liquid adding column, so that a relative movement trend is generated between the radial flange of the dripping plug at the outlet end of the liquid adding column and the pull rod support plate. The present application can quickly switch the sealing and flow states of the outlet ends of all liquid adding columns without cross contamination problems.
Description
Technical Field
The invention relates to an extraction column placement device capable of limiting reagent outflow, in particular to a simple, quick and convenient sample pretreatment technology in laboratory application.
Background
Extraction is a unit operation that utilizes the difference in partition coefficient of solvents between mutually immiscible two phases to make them purified or concentrated. Since the proper extractant and flow can be selected according to the separation object and requirements. Therefore, the method has the characteristics of high selectivity, good separation effect, strong adaptability and the like. The solvent extraction is usually carried out at normal temperature or low temperature, has low energy consumption, is particularly suitable for separating heat-sensitive substances, and is easy to realize large-scale continuous production. In recent years, extraction is increasingly widely applied in the fields of high and new technologies such as atomic energy, hydrometallurgy, petroleum, chemical industry, medicine, environmental protection and the like, and extraction equipment is continuously developed and updated along with the wide application of extraction in industry.
The solid phase extraction is a sample pretreatment technology developed from the mid-eighties, and is to adsorb target compounds in a liquid sample by using a solid adsorbent, separate the target compounds from a matrix and interfering compounds of the sample, and then use eluent for elution or heating desorption to achieve the purposes of separating and enriching the target compounds. Compared with the traditional liquid-liquid extraction method, the solid-phase extraction method does not need a large amount of solvents which are mutually insoluble, does not generate emulsification phenomenon in the treatment process, can improve the recovery rate of the analyte, can obviously reduce the dosage of the solvents, simplifies the sample treatment process, reduces the required cost, reduces the sample pretreatment process, and is simple to operate, time-saving and labor-saving. Solid phase extraction is used as a sample pretreatment technology, is increasingly widely applied in laboratories, and is widely applied in the fields of medicine, food, environment, business inspection, chemical industry and the like.
As a simple, rapid and convenient sample pretreatment technology, the invention has only been over ten years old, and the unique balance mode and sampling thought have been widely focused by students at home and abroad in recent years, and have been rapidly developed. The solid phase extraction has various small column forms, different applicable occasions and different requirements, the existing 5ml solid small column is easy to drain in the use process, liquid leakage can occur in the moving process, pipelines are disordered, the number of electromagnetic valves is large, the solid adsorbent has different densification degrees, and the problems of cross contamination and the like are easy to cause in the extraction process.
Disclosure of Invention
It is therefore an object of the present invention to provide an extraction column placement apparatus capable of restricting the flow of reagent to solve at least one of the above problems of the prior art.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the extraction column placement device is characterized by comprising a movable column frame, a sliding column pressing plate positioned above the movable column frame, a pull rod supporting plate fixed below the movable column frame, and a liquid adding column with two ends respectively fixed on the movable column frame and the pull rod supporting plate;
the outlet end of the liquid adding column is provided with a liquid dropping plug which is provided with a linear gap kept sealed in a normal state, the liquid dropping plug is also provided with a radial flange which can open the linear gap, and the lower side of the radial flange is correspondingly contacted with the pull rod supporting plate;
The inlet end of the liquid adding column is in sealing connection with the lower side of the sliding column pressing plate through a sealing element, and the sliding column pressing plate can be controlled to downwards apply force to the inlet end of the liquid adding column, so that a relative movement trend is generated between the radial flange of the liquid dropping plug at the outlet end of the liquid adding column and the pull rod supporting plate.
The extraction column placement device comprises a column adapter arranged at the inlet end of the liquid adding column, wherein the column adapter is cylindrical and is matched with the inlet end of the liquid adding column in shape to form sealing connection, and a sliding plunger is connected to the column adapter in a sealing manner and can form sealing connection with a gun head.
The extraction column placement device comprises a liquid drop plug, a liquid adding column and a liquid filling pipe, wherein the liquid drop plug is provided with a pipe body, one end of the pipe body is opened and can be in sealing sleeve connection with the outlet end of the liquid adding column, a sealing piece is integrally formed at the other end of the pipe body, the linear gap is formed on the sealing piece, and the radial flange is integrally formed at the opposite outer side of the pipe body.
The extraction column placing device is characterized in that the drop plug is made of silicone rubber.
The extraction column placement device is characterized in that the drip plug is provided with two radial flanges, and the two radial flanges are rectangular in overlook.
The extraction column placement device is characterized in that a plurality of upper stepped holes are formed in the movable column frame, each upper stepped hole can be used for inserting and fixing the upper end of one liquid adding column, a plurality of lower stepped holes are formed in the pull rod supporting plate, each lower stepped hole can be used for placing a liquid dropping plug sleeved on the outlet end of one liquid adding column, and two radial flanges of the liquid dropping plug are in contact with the stepped surfaces of the lower stepped holes.
The extraction column placing device comprises a sliding column pressing plate, a movable column frame and a sliding column pressing plate.
The extraction column placing device is characterized in that a horn mouth is arranged at the sliding column pressing plate corresponding to the opening end of each liquid adding column, and the opening end of the liquid adding column, the column adapter, the sliding plunger and the lower surface of the horn mouth are in sealing connection in sequence.
The extraction column placing device is characterized in that a plurality of upper counter bores are formed in the movable column frame from top to bottom, a plurality of lower counter bores are formed in the pull rod supporting plate from bottom to top, and upper screws inserted into the upper counter bores and lower screws inserted into the lower counter bores are respectively connected with two ends of a sliding column pull rod through threads, so that the movable column frame is connected with the pull rod supporting plate.
The extraction column placing device is characterized in that two ends of the movable column frame are respectively provided with a sliding column stop block.
The invention has the advantages that:
1. the liquid adding column can solve the problems that small columns are easy to drain in the use process, liquid can leak in the moving process, pipelines are disordered, the number of electromagnetic valves is large, the solid adsorbents are different in densification degree, cross contamination is easy to cause in the extraction process, and the like.
2. In order to facilitate smooth sliding under the action of external force, reduce friction force, make circular arc and slide bar diameter the same as each other as much as possible, ensure smooth sliding process, reduce contact surface of movable column frame and slide bar as much as possible, and reduce contact surface of movable column frame and slide bar, it is characterized by that it uses the guide of installation process to slide into equipment along angle so as to make it easy to install and reduce correspondent friction force, and adopts floating installation mode to make it easy to install in equipment.
3. According to the invention, the plurality of liquid adding columns are assembled together, so that the sample processing efficiency is greatly improved, the operation is simple, the replacement is convenient, the experimental precision is high, and the labor intensity of experimental staff is reduced.
Drawings
Fig. 1 is a perspective view of the present invention.
FIG. 2 is a sectional view of the assembly of the liquid feeding column of the present invention.
FIG. 3 is a diagram of a single 5ml liquid column assembly according to the present invention.
Fig. 4 is an assembled drawing of the tie rod of the present invention.
Fig. 5 and 6 are longitudinal sectional and bottom views, respectively, of the drip plug of the present invention.
The reference numerals illustrate 1-moving column frame, 2-slide column stop, 3-slide column pull rod, 4-pull rod supporting plate, 5-upper screw, 6-lower screw, 7-liquid adding column, 8-column adapter, 9-slide plunger, 10-slide column pressing plate, 11-liquid dropping plug, 12-pressing plate screw, 13-sealing piece, 14-linear gap, 15-radial flange, 16-step surface and 17-horn mouth.
Detailed Description
The invention will be further elucidated with reference to the drawings and the detailed description.
The invention provides an extraction column placement device capable of limiting the outflow of a reagent, which comprises a movable column frame 1, a sliding column pressing plate 10 positioned above the movable column frame 1, a pull rod supporting plate 4 positioned below the movable column frame 1, a liquid adding column 7 with two ends respectively fixed on the movable column frame 1 and the pull rod supporting plate 4, and a sliding column pull rod 3 connected with the movable column frame 1 and the pull rod supporting plate 4, as shown in fig. 1,2 and 4.
As shown in fig. 3, the application is provided with a column adapter 8 at the inlet end of the liquid adding column 7 (represented by a liquid adding column 7 with 5ml specification), wherein the column adapter 8 is cylindrical and is matched with the shape of the inlet end of the liquid adding column 7 to form a sealing connection, a sliding plunger 9 is connected on the column adapter 8 in a sealing way, and the sliding plunger 9 can form a sealing connection with a gun head;
As shown in fig. 5 and 6, the outlet end of the liquid adding column 7 is provided with a liquid dropping plug 11, the liquid dropping plug 11 is provided with a pipe body, one end of the pipe body is opened and can be in sealing connection with the outlet end of the liquid adding column 7, the other end of the pipe body is integrally formed with a sealing piece 13, a linear gap 14 is formed on the sealing piece 13, the linear gap 14 can normally keep the sealing of the outlet end of the liquid adding column 7 under normal pressure, in addition, the opposite outer sides of the pipe body are integrally formed with radial flanges 15 (of course, a circle of radial flanges is included), the whole liquid dropping plug 11 is made of elastic materials, when the two radial flanges 15 are subjected to axial force, the sealing piece 13 is deformed, and the linear gap 14 is deformed accordingly, so that the sealing of the outlet end of the liquid adding column 7 is not kept.
Referring to fig. 1 and 2, the movable column frame 1 is formed with a plurality of upper stepped holes, each of which is used for inserting and fixing the upper end of one of the liquid adding columns 7, the pull rod supporting plate 4 is formed with a plurality of lower stepped holes, each of which is used for placing a liquid dropping plug 11 sleeved on the outlet end of one of the liquid adding columns 7, and the radial flange 15 of the liquid dropping plug 11 is in contact with the stepped surface 16 of the lower stepped hole;
A sliding column pressing plate 10 is further arranged on the movable column frame 1, the sliding column pressing plate 10 is connected with the movable column frame 1 through pressing plate screws 12, a horn mouth 17 is arranged at the sliding column pressing plate 10 corresponding to the opening end of each liquid adding column 7, and sealing connection is formed on the opening end of each liquid adding column 7, the column adapter 8, the sliding plunger 9 and the lower surface of the horn mouth 17 in sequence;
Referring to fig. 1 and 4, the movable column frame 1 is provided with a plurality of upper counter bores from top to bottom, the pull rod supporting plate 4 is provided with a plurality of lower counter bores from bottom to top, the upper screw 5 inserted into the upper counter bores and the lower screw 6 inserted into the lower counter bores are respectively connected with two ends of the slide column pull rod 3 through threads, the movable column frame 1 and the pull rod supporting plate 4 are connected together, the falling depth of the upper screw 5 and the lower screw 6 is adjusted, the distance between the movable column frame 1 and the pull rod supporting plate 4 is consistent with the length of the liquid adding column 7, the radial flange 15 of the liquid dropping plug 11 and the step surface 16 of the lower stepped hole do not generate opposite acting force in a normal state, the linear gap 14 of the sealing piece 13 of the liquid dropping plug 11 is in a sealing state, and liquid in the liquid adding column 7 cannot flow out.
Once the module brings the gun head to apply external force to the plunger 9 at the plunger pressing plate 10, the plunger 9 is sealed with the gun head, and then the column adaptor 8 extrudes the liquid adding column 7 by the external force supplied by the module, the liquid adding column 7 is wholly displaced downwards, the radial flange 15 of the liquid dropping plug 11 is blocked by the step surface 16 of the lower stepped hole, the sealing piece 13 is deformed, the linear gap 14 is deformed, sealing is not maintained, and the liquid in the liquid adding column 7 flows out from the outlet end.
Therefore, by adopting the structure, the sealing and circulating states of the outlet ends of all the liquid adding columns 7 can be rapidly switched, and the outlet ends of the liquid adding columns 7 have no pipelines or valves, so that the problems of cross contamination, too many pipelines for obstructing operation, attractive appearance and the like in the moving process can be avoided.
As shown in figure 1, two ends of the movable column frame 1 are respectively provided with a sliding column stop block 2, so that the whole equipment can be integrally moved while keeping complete, the whole device can not be independently moved in operation and can only be driven by external power to slide to a collecting bottle, an elution tank, a waste liquid tank and the like.
In order to facilitate smooth sliding under the action of external force during design, reduce friction force, make the arc size identical to the diameter of the slide bar as much as possible, ensure smooth sliding process, and in addition, in order to avoid adding additional friction force and convenient installation, under the condition of ensuring smooth sliding process, the contact surface between the movable column support 1 and the slide bar is reduced as much as possible, the lower end of the movable column support 1 is specially processed into a certain shrinkage angle, and the movable column support is guided in the installation process to slide into equipment along the angle so as to facilitate better installation and reduce corresponding friction force, and the material is selected from acid-resistant PP material, so that the whole column support can be quickly moved in the equipment.
The material of the drip plug 11 is preferably a silicone rubber material, which has good elasticity and can realize multiple opening and closing actions, and the two radial flanges 15 are preferably rectangular in plan view so as to ensure left and right rotation prevention.
The above description is illustrative of the invention and is not to be construed as limiting, and it will be understood by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (4)
1. The extraction column placement device is characterized by comprising a movable column frame, a sliding column pressing plate positioned above the movable column frame, a pull rod supporting plate fixed below the movable column frame, and a liquid adding column with two ends respectively fixed on the movable column frame and the pull rod supporting plate;
the inlet end of the liquid adding column is provided with a column adapter which is cylindrical and is matched with the shape of the inlet end of the liquid adding column to form sealing connection;
A liquid drop plug is arranged at the outlet end of the liquid adding column, the liquid drop plug is provided with a linear gap which keeps sealing in a normal state, the liquid drop plug is also provided with a radial flange which can enable the linear gap to be opened, and the lower side of the radial flange is correspondingly contacted with the pull rod supporting plate; the liquid dropping plug is provided with a pipe body, one end of the pipe body is opened to be capable of being in sealing sleeve connection with the outlet end of the liquid adding column, a sealing sheet is integrally formed at the other end of the pipe body, the linear gap is formed on the sealing sheet, two radial flanges are integrally formed at the opposite outer sides of the pipe body, and the two radial flanges are rectangular in overlook view;
The inlet end of the liquid adding column is in sealing connection with the lower side of the sliding column pressing plate through a sealing element, and the sliding column pressing plate can be controlled to downwards apply force to the inlet end of the liquid adding column, so that the radial flange of the liquid dropping plug at the outlet end of the liquid adding column and the pull rod supporting plate generate relative movement trend;
a plurality of upper stepped holes are formed in the movable column frame, each upper stepped hole can be used for inserting and fixing the upper end of one liquid adding column, a plurality of lower stepped holes are formed in the pull rod supporting plate, each lower stepped hole can be used for placing a liquid dropping plug sleeved on the outlet end of one liquid adding column, and two radial flanges of the liquid dropping plug are in contact with the step surfaces of the lower stepped holes;
the sliding column pressing plate is provided with a horn mouth corresponding to the opening end of each liquid adding column, and the opening end of the liquid adding column, the column adapter, the sliding plunger and the lower surface of the horn mouth are sequentially connected in a sealing way;
the movable column frame is provided with a plurality of upper counter bores from top to bottom, the pull rod supporting plate is provided with a plurality of lower counter bores from bottom to top, and an upper screw inserted into the upper counter bores and a lower screw inserted into the lower counter bores are respectively connected with two ends of a sliding column pull rod through threads, so that the movable column frame is connected with the pull rod supporting plate.
2. The extraction column placement apparatus of claim 1, wherein the drip plug is made of silicone rubber.
3. The extraction column placement apparatus of claim 1, wherein the spool platen is coupled to the movable column frame by platen screws.
4. The extraction column placement apparatus of claim 1, wherein a slide block is further provided at each end of the movable column frame.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210519095.2A CN114797174B (en) | 2022-05-12 | 2022-05-12 | Extraction column placement device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210519095.2A CN114797174B (en) | 2022-05-12 | 2022-05-12 | Extraction column placement device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114797174A CN114797174A (en) | 2022-07-29 |
| CN114797174B true CN114797174B (en) | 2025-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210519095.2A Active CN114797174B (en) | 2022-05-12 | 2022-05-12 | Extraction column placement device |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN217430893U (en) * | 2022-05-12 | 2022-09-16 | 北京莱伯泰科仪器股份有限公司 | Extraction column placing device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008107176A (en) * | 2006-10-25 | 2008-05-08 | Hitachi High-Technologies Corp | Separation column and liquid chromatograph using the same |
| CN204891288U (en) * | 2015-09-01 | 2015-12-23 | 大连众信检测技术有限公司 | Portable on -vehicle solid -phase extraction device of detachable |
| CN207980505U (en) * | 2018-02-08 | 2018-10-19 | 武汉净澜检测有限公司 | A kind of solid-phase extraction device |
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2022
- 2022-05-12 CN CN202210519095.2A patent/CN114797174B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN217430893U (en) * | 2022-05-12 | 2022-09-16 | 北京莱伯泰科仪器股份有限公司 | Extraction column placing device |
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| CN114797174A (en) | 2022-07-29 |
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