CN114814189A - a detection device - Google Patents

Abstract

The invention provides a detection device, which comprises a storage cavity, wherein an additive is arranged in the storage cavity, a sharp part is arranged in the detection device, the storage cavity can move relative to the sharp part, the storage cavity can be punctured by the sharp part in the moving process of the storage cavity, so that the additive in the storage cavity can be released, the detection device also comprises a collection cavity, the released additive can enter the collection cavity, the collection cavity is used for accommodating a sample, the collection cavity is arranged in a first shell, an opening is arranged at the upper side position of the first shell, a test element for detecting an analyzed substance is arranged in the collection cavity, the test element is arranged on a carrier, and the carrier and the collection cavity have a specific matching form. The buffer solution is arranged in an independent cavity in the detection device, and can be obtained at any time when detection is needed, so that the use is very convenient; the carrier has a specific form of fit with the collection chamber in the first housing to allow a defined, unique orientation of the carrier after insertion into the collection chamber.

Description

a detection device

technical field

The invention relates to the technical field of in vitro rapid detection, in particular to a device for collecting and detecting analytes in liquid samples in the field of rapid diagnosis, such as a urine and saliva collection and detection device.

Background technique

The following description of the background art is only the introduction of some background common sense, and will not constitute any limitation to the present invention.

At present, detection devices for detecting whether a sample contains analyte substances are widely used in hospitals or at home. These detection devices for rapid diagnosis include one or more detection reagent strips, such as early pregnancy detection, drug abuse detection, etc. Wait. This kind of rapid diagnosis detection device is very convenient, and the detection result can be obtained on the detection reagent strip in one minute, or at most ten minutes.

Drug detection is widely used, and is often used in anti-drug departments, public security bureaus, drug rehabilitation centers, physical examination centers, national military recruitment physical examination offices and other institutions. Drug testing is varied and frequent. Some need to collect samples, and then need professional testing institutions or testing laboratories for testing. Some need to complete on-site testing in a timely manner. For example, people who drive after taking drugs (referred to as "drug drivers") need to conduct on-site testing, and then obtain the test results in a timely manner. For drug testing, samples can be urine, sweat, hair and saliva samples.

In some tests, in order to obtain more accurate test results, the test personnel will add buffer solution to the sample during the test process, so as to keep the pH value of the solution relatively stable to a certain extent. Since the buffer solution is exposed to the air at room temperature for a long time, bacteria will grow, and the metabolites of the bacteria will change the pH of the buffer solution. Therefore, in order to avoid contact with air, the buffer solution is generally not directly located in the detection device. In most cases, the buffer solution It is stored separately from the detection device, and additionally added during detection, which is very cumbersome to operate.

Therefore, it is necessary to improve the existing traditional detection device to provide a device for collecting samples and performing detection in a simpler manner.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a detection device to solve the above-mentioned problems in the background art.

In order to achieve the above purpose, the technical solution adopted by the present invention is a detection device, which includes a storage cavity, an additive in the storage cavity, a sharp part in the detection device, and the storage cavity can move relative to the sharp part. , the storage chamber is punctured by a sharp point, allowing the contents of the storage chamber to be released.

Further, a collection cavity is also included, and the released additive can enter into the collection cavity.

Further, the collection cavity is used for accommodating the sample, the collection cavity is provided in the first housing, and an opening is provided on the upper side of the first housing. Further, the collection chamber is provided with a test element for detecting the analyte.

Further, the test element is arranged on the carrier, the carrier and the collection cavity have a specific matching form, the carrier can be inserted into the collection cavity from the opening at the upper side of the first housing, and the carrier has a definite and unique shape after being inserted into the collection cavity. direction location.

Further, clips are arranged in the collection cavity, a carrier is fixed by two clips, and the side of the carrier on which the test element is mounted is attached to the inner wall of one side of the collection cavity.

Further, the thickness of the upper end of the clip is smaller, and the thickness of the lower end is larger; correspondingly, the thickness of the bottom position of the carrier is smaller, and the thickness of the top position of the carrier is larger.

Further, the corners of the collecting cavity are provided with rounded corners; correspondingly, the two sides of the side on which the test element is mounted on the carrier are also provided with rounded corners.

Further, it also includes a sample collector for collecting samples, the sample collector includes a capped end, and the capped end can be used to cap the opening of the collection chamber.

Further, the sample collector also includes a sampling end and a rod body, the sampling end is connected to the absorbing element, the rod body is used for connecting the capping end and the sampling end, and the rod body and the capping end are detachably connected.

Further, holes are provided on the sample collector and/or the collection chamber, and the holes allow the collection chamber to communicate with the outside world.

Further, a hollow tube extending in the direction of the collection cavity is provided on the cover end at the position of the hole.

Further, the diameter of the hole is less than 1 mm.

Further, the liquid in the storage chamber is a buffer.

Further, the cover end of the sample collector is provided with a connecting head on the side facing away from the rod body. The interior of the connecting head is hollow, and the storage cavity can enter into its hollow position.

Further, the sharp part is in a protruding shape and is arranged in the hollow position of the connector.

Further, the storage cavity is arranged in the second shell, and a layer of sealing film is arranged on the second shell to seal the liquid in the storage cavity. The storage cavity enters the hollow position of the connecting head, and the sharp part can pierce the first The sealing film on the two shells releases the liquid in the storage cavity.

Further, the sharp part is provided with a through hole penetrating up and down.

Further, the second casing is provided with a second sealing ring, and the second sealing ring can fill the gap between the second casing and the connecting head.

Further, the detection device further includes a cover body, and the cover body is connected with the second casing, and the connection relationship is detachable or non-detachable.

Further, the cover body and the connecting head can cover each other.

Further, the cover body and the connecting head are provided with matching threads.

Further, the upper end of the cover body and the second shell of the second shell is provided with a rotating part, the rotating part is provided with a first protrusion, the cover body is provided with a connecting hole, and the rotating part can be inserted into the connecting hole and pass through the first protrusion. A protrusion is buckled on the connecting hole, so that the second shell can rotate on the connecting hole.

Further, the detection device further includes a protection element for limiting the over-closing of the cover.

Further, the detection device also includes a protection element for limiting the over-covering of the cover body, the protection element includes a support section, the support section is sleeved on the connecting head, the lower end of the support section can abut with the upper surface of the cover end, and the upper end of the support section Can abut with the cover.

Further, the support section is a hollow cylindrical shape, which is sleeved on the connecting head.

Further, the support section of the protection element is provided with a first notch.

Further, the protective element has elasticity.

Further, the protection element further includes a grip portion, the grip portion is provided with stripes, the grip portion is connected to the support section, and the connection position of the grip portion and the support section is just opposite to the first gap.

Further, the protective element is provided with a second protrusion protruding inward at the bottom position of the support section, and the second protrusion is annular. Correspondingly, the connecting head is also provided with an annular structure near the bottom, and the second protrusion It can be snapped into the gap between the annular structure and the upper surface of the closing end.

Further, the annular structure is provided with a second gap, and correspondingly, the inner side of the support section of the protection element is provided with a third protrusion facing the first gap, and the third protrusion can be embedded in the second gap. .

Further, the cover end is rectangular, and the second notch is located on the side close to the long side of the cover end.

Further, the support section of the protection element is provided with a blocking wall, and the blocking wall is arc-shaped.

Further, the inner diameter of the protection element at the position of the blocking wall is larger than the inner diameter of the protection element at the position of the support section.

Further, the inner side of the baffle wall is provided with a buckle, and a ring of flanges is arranged at the bottom of the cover body, and the flange of the cover body can enter into the baffle wall and be buckled under the buckle.

Further, the upper end of the flange is horizontal, and the lower end surface of the buckle is also horizontal; the upper end of the buckle is inclined, and the lower side of the flange of the cover body is provided with a chamfer.

To sum up, the beneficial effects of the present invention are: the buffer solution is arranged in an independent cavity in the detection device, and the buffer solution can be obtained at any time when detection is required, which is very convenient to use; the carrier and the collection cavity in the first shell have specific characteristics The matching form allows the carrier to have a definite and unique directional position after being inserted into the collection chamber; the sample collector is provided with a hole connecting the collection chamber and the outside air, which can eliminate the problem of capping caused by the air pressure during the use of the detection device. There is a hollow tube extending toward the collection cavity on the closed end at the hole position, which can avoid the leakage of the sample; the bottom of the collection cavity is provided with an upwardly open truncated truncated pressing part. When the sample is squeezed in contact with the upper part, in addition to the absorbing element and the bottom of the pressing part, the circular frustum-shaped opening can also squeeze the side part of the absorbing element, which improves the extrusion efficiency and also releases more In addition, it can also play a certain role in collecting samples; the detection device also includes a protective element for limiting the over-closing of the cover, which can prevent the storage cavity from being punctured by sharp parts before detection; the outer surface of the carrier There are multiple grooves on it, which can be used to install different test components and realize the function of multiple detections in a single time.

Description of drawings

Fig. 1 is the overall structure schematic diagram of detection device;

Fig. 2 is a complete exploded view of the detection device;

Fig. 3 is the schematic diagram when the carrier is installed in the first housing;

4 is a front cross-sectional view of the first housing;

Figure 5 is a side sectional view of the first housing;

Fig. 6 is the exploded view when the detection device is used;

Fig. 7 is the partial enlarged schematic diagram of "A" area in Fig. 6;

8 is a top view of the first housing;

Fig. 9 is the structural representation of the cover end;

Figure 10 is a schematic structural diagram of installing a second housing in the cover;

FIG. 11 is a schematic structural diagram of a protection element.

Detailed ways

The structures involved in the present invention or the technical terms used are further described below. If there is no special indication, they should be understood and interpreted according to the general terms commonly used in the art.

detect

Detection means assaying or testing for the presence of a substance or material such as, but not limited to, chemicals, organic compounds, inorganic compounds, metabolites, drugs or drug metabolites, organic tissue or metabolites of organic tissue, nucleic acids, protein or polymer. In addition, detection refers to the quantity of a test substance or material. Further, the assay also means immunoassay, chemical assay, enzymatic assay, and the like.

sample

Detection devices or collected samples of the present invention include biological fluids (eg, patient fluids or clinical samples). Liquid samples or liquid samples, or fluid samples or fluid samples, can be derived from solid or semi-solid samples, including excreta, biological tissue and food samples. A solid or semi-solid sample can be converted to a liquid sample by any suitable method, such as mixing, mashing, macerating, incubating, dissolving or using enzymes in a suitable solution (eg water, phosphate solution or other buffer solution) Digestion of solid samples. "Biological samples" include animal, plant and food samples, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, of human or animal origin, Organs, tumors, tissues and organ cultures, cell cultures and media. Preferably the biological sample is urine, preferably the biological sample is saliva. Food samples include food-processed substances, final products, meat, cheese, wine, milk and reference water. Plant samples include those derived from any plant, plant tissue, plant cell culture and media. "Environmental samples" are derived from the environment (eg, liquid samples from lakes or other bodies of water, sewage samples, soil samples, groundwater, seawater, and waste liquid samples). Environmental samples may also include sewage or other waste water.

Any analyte can be detected using a suitable detection element or test element of the present invention. Preferably, the present invention is used to detect small drug molecules in saliva and urine. Of course, any of the above forms of samples can be collected using the collection device of the present invention, whether initially solid or liquid, as long as these liquids or liquid samples can be absorbed by the absorbing element. The absorbent element here is generally made of water-absorbing material, which is initially dry, and can absorb liquid samples or fluid samples through the capillary or other properties of the material of the absorbent element. The absorbent material can be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, non-woven fabric, cotton, polyester film, yarn, and the like. Of course, the absorbent element does not have to be made of absorbent material, it can be made of non-absorbent material, but there are holes, threads, holes on the absorbent element, and samples can be collected on these structures. These samples are generally solid or semi-solid samples. These samples are Fill between threads, holes, or holes.

downstream and upstream

Downstream or upstream is divided for the direction of liquid flow, generally the liquid flows from the upstream to the downstream area. The downstream region receives liquid from the upstream region, and the liquid can also flow along the upstream region to the downstream region. This is generally divided according to the direction of liquid flow. For example, on some materials that use capillary force to promote liquid flow, the liquid can flow in the opposite direction of gravity. At this time, the upstream and downstream are still divided according to the flow direction of the liquid. .

Gas communication or liquid communication

Gas communication or liquid communication means that liquid or gas can flow from one place to another, and may pass through some physical structures to guide the flow. The so-called physical structure generally refers to the liquid passing through the surface of these physical structures, or the internal space of these structures and passively or actively flowing to another place. Passive is generally the flow caused by external force, such as capillary action. flow. The flow here can also be a liquid or gas due to its own action (gravity or pressure), or it can be a passive flow. The connection here does not necessarily mean the existence of liquid or gas, but only indicates the connection relationship or state between two objects in some cases. If there is liquid, it can flow from one object to another. This refers to the state in which two objects are connected. On the contrary, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, such a state It is a state of non-communication, non-liquid or gas communication.

test element

The so-called "test element" here refers to the element that can detect the sample or whether the sample contains the analyte of interest. It can be called the test element. This detection is based on whatever technical principle, immunology, chemistry, electricity, Optical, molecular, nucleic acid, physics, etc. The test element can be selected as a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention.

Various test elements can be used in combination with the present invention. One form is test strips. Test strips for analysis of analytes (eg, drugs or metabolites indicative of medical conditions) in a sample can be in various formats, such as in the form of immunoassays or chemical assays. The test strips can be analyzed in a non-competitive or competitive mode. The test strip generally includes a water-absorbing material with a sample application area, a reagent area and a test area. Add the sample to the sample application area, and flow to the reagent area by capillary action. In the reagent area, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized in the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte in this zone, or bind to one of the reagents in the reagent zone. The label used to display the detection signal is present in the reagent zone or separate label zone.

In a typical non-competitive assay mode, a signal is generated if the analyte is present in the sample, and no signal is generated if the analyte is not present. In the competition method, a signal is generated if the analyte is not present in the sample, and no signal is generated if the analyte is present.

The test element can be a test paper, and a material that absorbs or does not absorb water can be selected. Test strips can include a variety of materials for liquid sample transfer. One of the test paper materials can be overlaid on another material, such as filter paper overlaid on a nitrocellulose membrane. One area of the test strip can be selected from one or more materials, while the other area can be selected from other different materials or materials. Test strips can be adhered to a support or hard surface to increase the strength of the test strips.

The analyte is detected by a signal generating system, such as using one or more enzymes that specifically react with the analyte, using the method of immobilizing the specific binding substance on the detection test paper as described above, and combining one or more enzymes. The composition of the signal generating system is immobilized on the analyte detection area of the test strip. The signal-generating substance may be in the sample application area, the reagent area, or the detection area, or the entire test strip, and the substance may impregnate one or more materials of the test strip. The signal-containing solution is added to the surface of the test paper or one or more materials of the test paper are immersed in the signal-containing solution. The test paper to which the signal containing solution was added was allowed to dry.

The various areas of the test strip can be arranged in the following ways: sample addition area, reagent area, detection area, control area, determination of whether the sample is adulterated or not, and liquid sample absorption area. The control area is located after the detection area. All zones can be arranged on a strip of test strips using only one material. It is also possible to use different materials for different zones. Each zone can be in direct contact with the liquid sample, or different zones can be arranged according to the direction of the liquid sample flow, and the end of each zone can be connected and overlapped with the front end of another zone. The material used can be a material with better water absorption such as filter paper, glass fiber or nitrocellulose membrane. Test strips can also take other forms.

The commonly used reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. . For example, the following patents describe reagent strips or devices containing reagent strips: US 4,857,453; US 5,073,484; US 5,119,831; US 5,185,127; US 5,275,785; US 5,766,961; US 5,770,460; US 5,916,815; US 5,976,895; US 6,248,598; US 6,140,136; The test strips disclosed in the above patent documents and similar devices with test strips can be applied to the test element or detection device of the present invention to detect the analyte, such as the detection of the analyte in the sample.

The detection reagent strips used in the present invention may be so-called lateral flow test strips. The specific structures and detection principles of these detection reagent strips are well known to those skilled in the art in the prior art. A common detection reagent strip includes a sample collection area or a sample application area, a labeling area, a detection area and a water absorption area. The sample collection area includes a sample receiving pad, and the labeling area includes a labeling pad. Including the necessary chemical substances that can detect whether the analyte is contained, such as immunological reagents or enzymatic chemical reagents. The commonly used detection reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Etc., of course, a detection result control area may also be included downstream of the detection area. Usually, the control area and the detection area appear in the form of horizontal lines, which are detection lines or control lines. Such detection reagent strips are traditional reagent strips, and of course, other types of reagent strips that utilize capillary action for detection can also be used. In addition, the general detection reagent strip has dry chemical reagent components, such as immobilized antibodies or other reagents. When encountering liquid, the liquid flows along the reagent strip with capillary action, and with the flow, the dry reagent components are dissolved in the The liquid, thereby going to the next zone for processing, reacts with the dry reagents in that zone to perform the necessary detection. Liquid flow occurs primarily through capillary action. All of these can be applied to the detection device of the present invention, or are arranged in the detection chamber to contact the liquid sample, or used to detect the presence or quantity of the analyte in the liquid sample entering the detection chamber.

Except that the above-mentioned test strip or the lateral flow test strip itself is used to contact the liquid sample to test whether the liquid sample contains the analyte. In some preferred manners, the test elements can also be arranged on some carriers, as shown in FIG. 3 , for example, some carriers 40 , the carrier has many grooves 43 , and the test elements are located in the grooves 43 . In some implementations, the carrier 40 includes a recessed area in which the test elements are disposed, and a plurality of recesses are disposed in the area, each recess may be disposed with a test strip, and each test strip may detect an analyte. The carrier 40 is in a form matching the collection cavity 22 . For example, the collection cavity 22 is a square cavity here. Correspondingly, a plate-shaped carrier 40 can be placed in the collection cavity 22 . On the outer surface of the carrier 40 , a plurality of Grooves 43, these grooves 43 are also evenly arranged in an array. Test elements are placed in the grooves 43. The test elements can be test strips. The two sides in the groove 43 are provided with sharp corners 41. The sharp corners 41 can The test strip is clamped in the groove 43 and mainly serves to fix the test strip. In some ways, after the test element is arranged in the groove 43 of the carrier 40, a transparent film is covered on the carrier 40, one is to seal the groove area of the carrier 40, and the transparent film is easy to observe the final detection area. Test results above. The transparent film can also be a transparent plastic sheet, which is only transparent in the test area.

Generally, the test strip includes a sample application area, a marking area and a detection area. When placing the test strip, the sample application area is placed close to the bottom of the carrier, and then the groove is slightly exposed, such as 2-3 mm, reserved A portion of the sample application area is used to absorb the fluid sample flowing into the bottom of the collection chamber 22 . Typically, the sample application area is located upstream of the labeling area, which is located upstream of the detection area.

Carrier and collection chamber

The collection cavity is a place for accommodating samples. The first housing 20 is provided with a collection cavity 22. The collection cavity 22 includes an opening on the upper side of the first housing 20. The carrier 40 is inserted into the first housing 20 from the opening on the upper side of the first housing 20. in the collection chamber 22 . In some manners, the carrier 40 is in a specific matching form with the collection chamber 22 . With such a matching form, the carrier has a definite and unique directional position after being inserted into the collection chamber. Specifically, referring to FIG. 5 , the collection cavity 22 is provided with clips 21 , one carrier 40 is preferably fixed with two clips 21 , and the two clips 21 can restrict the carrier 40 to the collection cavity by restricting both sides of the carrier 40 22 and let the side of the carrier 40 with the test strips fit with the inner wall of one side of the collection cavity 22 . Further, referring to FIG. 5, the thickness of the upper end of the clip 21 is smaller, and the thickness of the lower end is larger. Accordingly, the thickness of the bottom position of the carrier 40 is smaller, and the thickness of the top position of the carrier 40 is larger. Such a design allows the carrier 40 to have a larger thickness. It cannot be inserted into the collection chamber 22 upside down. In addition, the corners of the collection cavity 22 are provided with rounded corners. Correspondingly, the sides of the carrier 40 on which the test strips are mounted are also provided with rounded corners, so that the carrier 40 only has rounded corners on the side where the test strips are mounted on the carrier 40 and the inner wall of the collection cavity 22 . It can only slide down when it is attached. When the side of the carrier 40 facing away from the test strip is attached to the inner wall of the collection cavity 22 and slides down, because the two sides of the side facing away from the test strip on the carrier 40 are non-rounded corners (both sides are sharp corners), During the sliding process, the non-rounded corners will be stuck with the rounded corners of the collection cavity 22 , so that the carrier 40 cannot be loaded into the collection cavity 22 , and a specific matching form of the carrier 40 and the collection cavity 22 is achieved.

analyte

Examples of analytes that can be used in the present invention include small molecules, including drugs (eg, drugs of abuse). "Substance of Abuse" (DOA) refers to the use of drugs (usually to paralyze nerves) for non-medical purposes. Abuse of these drugs can lead to physical and mental damage, dependence, addiction and/or death. Examples of drugs of abuse include cocaine; amphetamines AMP (eg, black beauty, white amphetamine tablets, dextroamphetamine, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal , speed); barbiturates BAR (eg, Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (ie, sleep aids); lysergic acid diethylamide (LSD); inhibitors (downers, goofballs, barbs, blue devils, yellow jackets, meprodol); tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline, and doxepin); MDMA; phencyclidine pyridine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e. morphine MOP or, opium, cocaine COC, heroin, oxycodone); anxiolytics Drugs and sedative-hypnotics, anti-anxiety drugs are a class of drugs mainly used to reduce anxiety, tension, fear, stabilize emotions, and have both hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ, fusion Diazepine NB23Cs, benzoazepines, ligands of BZ receptors, ring-opening BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazides Oxine and thiazole derivatives, other heterocycles, imidazole-type sedative/analgesics (such as oxydihydrocodeinone OXY, methadone MTD), propylene glycol derivatives - carbamates, aliphatic compounds, anthracene derivatives, etc. . The detection device of the present invention can also be used for the detection of drug overdose which belongs to medical use but is easy to take, such as tricyclic antidepressants (imipramine or the like) and acetaminophen. These drugs are metabolized into small molecular substances after being absorbed by the human body. These small molecular substances exist in blood, urine, saliva, sweat and other body fluids or in some body fluids.

For example, analytes detected with the present invention include, but are not limited to, creatinine, bilirubin, nitrite, proteins (non-specific), hormones (eg, human villi-stimulating hormone, progesterone hormone, follicle stimulating hormone, etc. ), blood, leukocytes, sugars, heavy metals or toxins, bacterial substances (such as proteins or carbohydrates against specific bacteria, such as e.g. Escherichia coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L. monocytogenes, Vibrio spp., or Cactobacillus spp.) and urine samples for substances related to physiological characteristics, such as pH and specific gravity. Any other clinical urine chemical analysis can be detected in the form of lateral lateral flow detection with the device of the present invention.

flow of liquid

The flow of liquid usually refers to the flow from one place to another. Under normal circumstances, the flow of liquids in nature mostly depends on the action of gravity to flow from high to low. The flow here also depends on external force, that is, external gravity. The flow under circumstances can become the flow of natural gravity. In addition to gravity, the flow of liquids can overcome gravity and move from low to high. For example, the extraction of liquid, or the compression of liquid, or the flow of liquid from the bottom to a high place under pressure, or the flow of the customer's liquid's own gravity due to the concern of pressure. For example, in this embodiment, if there is a liquid sample in the collection chamber 22, the liquid sample will be collected to the bottom of the collection chamber 22 under the action of gravity. When the liquid sample at the bottom of the collection chamber 22 contacts the lower end of the test paper on the carrier 40 When the liquid sample starts to flow from bottom to top by capillary force, the detection is carried out.

Sample collectors and collection chambers

The sample collector is used to collect samples. Specifically, as shown in FIG. 6 , the sample collector 30 includes a cover end 31 , a rod body 32 , and a sampling end 33 . The cover end 31 can be used to cover the opening of the collection cavity 22 to prevent the collection cavity. The sample in 22 leaks out, and the sampling end 33 is used to connect the absorbing element. The absorbing element can be made of a non-toxic sponge with strong water absorption. The absorbing element and the sampling end 33 can be bonded by special glue. When the sample collector 30 is along the collection cavity During the process of inserting the opening of 22 into the collection cavity 22, the absorbing element (not shown) on the sampling end 33 is pressed against the bottom of the collecting cavity 22, and the sample is extruded from the absorbing element. When moving down, the liquid sample in the absorbing element is continuously squeezed out until the capping end 31 completely covers the opening of the collection chamber 22. At this time, the sample collector 30 cannot continue to move downward, and the absorbing element is also in a squeezed state.

Preferably, the upper end of the rod body 32 is connected with the cap end 31 in a detachable manner, for example, by threaded connection, which is convenient for production.

During the process of capping the collection cavity 22 with the capping end 31, due to the airtightness inside the collection cavity 22, as the capping end 31 is closed, the air pressure inside the collection cavity 22 will increase, which will cause the capping end to be closed. 31 cannot be fully closed (the closure is not firm), or the closure end 31 is easy to pop out after the closure. Preferably, in order to eliminate the influence of air pressure, the sample collector 30 and/or the collection chamber 22 should be provided with a hole that allows the collection chamber 22 to communicate with the outside air. For example, in FIG. 7 , a hole 35 is provided on the cover end 31 , and the diameter of the hole 35 is less than 1 mm. Although the setting of the hole 35 can solve the problem of air pressure, the setting of the hole 35 also makes it possible for the capping end 31 to leak liquid samples. In order to avoid the leakage of the liquid sample as much as possible, the capping end 31 is provided with a The hollow tube 36 extends in the direction of the collection cavity 22. The hollow tube 36 can still keep the interior of the collection cavity 22 in communication with the outside world. At the same time, when the detection device is inverted, the liquid sample is collected to the position of the cover end 31 under the action of gravity. The hollow tube 36 raises the height of the hole at the communication position, and the hole cannot be in contact with the liquid sample, that is, the liquid sample cannot leak from the hole 35, and the diameter of the hole 35 is also small. Due to the existence of water tension, the liquid sample is further reduced. possibility of leakage.

Preferably, in order to squeeze out as much liquid sample as possible when the absorbing element on the sampling end 33 is squeezed with the bottom of the collection cavity 22, a squeeze portion 23 is provided at the bottom of the collection cavity 22, and the squeeze portion 23 is provided with The opening 24 that opens upward, the opening 24 is large at the top and small at the bottom, and is in the shape of a truncated cone. When the absorbing element on the sampling end 33 is in contact with the pressing part 23 to squeeze the sample, except that the absorbing element and the bottom of the pressing part 23 are squeezed In addition, the circular frustum-shaped opening 24 can also squeeze the side of the absorbent element, which improves the squeeze efficiency, releases more liquid samples, and also has a certain collection effect on the samples.

Here, the absorbent element is intended to absorb liquid samples, such as saliva, urine, sweat or other samples. The material of the absorbing element can be any water-absorbing material, such as sponge and the like.

Preferably, the collection chamber 22 is provided with sample grooves 25 on both sides of the pressing part 23 , the sample groove 25 is located directly below the carrier 40 , and the central position of the pressing part 23 is provided with a communication groove 26 connecting the two sample grooves 25 , the communication groove 26 keeps the liquid heights in the two sample grooves 25 the same when the detection device is laid flat. Since the carrier 40 is located just above the communication groove 26, when the samples in the sample groove 25 are collected, the two samples The samples in the groove 25 will simultaneously contact the lower ends of the test strips on the two carriers 40 for detection to avoid a situation where one carrier 40 has already started to detect while the other has not. Further, the height of the communication groove 26 is lower than the height of the pressing part 23 , so that the sample released by pressing the absorbing element can flow into the sample groove 25 as much as possible.

Preferably, two drainage ports 27 are provided in the collection chamber 22 on both sides of the sample tank 25 .

Preferably, in order to enable the cover end 31 to better cover the opening of the collection cavity 22 , the cover end 31 is provided with a first sealing ring 34 , and the first sealing ring 34 has elasticity and can well realize the cover end The seal between 31 and the opening of the collection chamber 22 prevents the liquid sample from flowing out. At the same time, the first sealing ring 34 increases the frictional force, so that the cover end 31 is not easily separated from the opening of the collection cavity 22. When the cover end 31 covers the opening of the collection cavity 22, the absorbing element is always in a compressed state and can be continuously released Liquid sample into collection chamber 22 .

Collection and storage chambers

The storage cavity is used to store additives. The additives can be solid, liquid, or gaseous. Common additives are liquid, such as buffer solution. The buffer solution is separately sealed in the storage cavity 90. When the sample collector is in the After the sample is collected, the storage chamber 90 needs to be opened and the buffer in the storage chamber 90 needs to be added to the collection chamber 22 to mix with the sample, and the obtained mixed liquid contacts the test paper on the carrier 40 for detection. By designing the size of the absorbing element to control the sample sampling amount of the absorbing element, or designing the size of the sample groove 25 to control the sample amount required when the sample is in contact with the test strip, the absorbing element on the sample collector can absorb the amount of the sample. After the liquid sample is completely released, the sample in the sample tank 25 cannot contact the test strip. Only after the buffer solution in the storage chamber 90 is added to the collection chamber 22, can the obtained mixed liquid come into contact with the detection test paper, and such a design can make the detection of the detection device more accurate.

Preferably, in the present invention, the storage cavity 90 is a separate cavity, which can be separated from the collection cavity 22 , the storage cavity 90 is arranged in the second casing 91 , and a layer of sealing film 92 is arranged on the second casing 91 , the sealing film 92 can be selected from aluminum foil to seal the buffer in the storage cavity 90 .

Preferably, in order to improve the integrity of the detection device and make it more convenient for the detection personnel to use, a connector 37 is provided on the side of the cover end 31 of the sample collector 30 facing away from the rod body 32 , the connector 37 is hollow inside, and the second housing is 91 can enter into its hollow position, the hollow position of the connector 37 is also provided with a sharp part 38 protruding upward, and the sharp part 38 is provided with a through hole 39 penetrating up and down, when the sealing film 92 on the second housing 91 One side is squeezed with the sharp part 38 , the sealing film 92 is punctured, the liquid in the storage cavity 90 leaks out, and enters the collection cavity 22 through the through hole 39 to mix with the sample. Further, since the second shell 91 can enter the hollow position of the connector 37, there is a gap between the second shell 91 and the connector 37, and the buffer solution in the storage cavity 90 is stored at the moment when the sealing film 92 is punctured. It may leak from the gap position, resulting in leakage of buffer solution. In order to solve this problem, a second sealing ring 93 is installed on the second housing 91. The second sealing ring 93 is preferably elastic. 91 enters the connecting head 37, and the second sealing ring 93 fills the gap between the second casing 91 and the connecting head 37, which solves the problem of buffer leakage.

After the introduction of the second sealing ring 93 , as the storage chamber 90 moves to the hollow position of the connector 37 , the air pressure in the storage chamber 90 may increase, which may hinder the movement of the storage chamber 90 . The hole 35 provided on the closing end 31 can well eliminate the influence of the air pressure in the storage cavity 90, and also solve the potential technical problem here.

cover

Since the second housing 91 can be taken out or installed in the connecting head 37, they are two parts. When the two parts are in use, the inspectors are easy to misunderstand the use of the device without being familiar with the use method of the device. A part is considered useless, resulting in the loss of parts. In order to solve this problem, it is necessary to enhance the integrity of the detection device, so that the detection personnel know how to use the device when they see the device, and know that the two components are used in combination. Preferably, the detection device further includes a cover body 80, the cover body 80 is connected with the second housing 91, and this connection relationship can be detachable or non-detachable, the cover body 80 and the connector 37 They can cover each other. For example, the common cover 80 and the connector 37 are provided with matching threads, so that the cover 80 can be screwed onto the connector 37. During the tightening process of the cover 80, the cover 80 drives the second shell. The body 91 moves toward the sharp part 38 until the sharp part 38 pierces the sealing membrane 92 .

After the detection device includes the cover body 80, the second sealing ring 93 may not be provided, because the cover body 80 can also play a certain anti-leakage effect. As a preferred technical solution, the detection device still retains the second sealing ring 93, because when the sharp part 38 pierces the sealing film 92, the cover body 80 is not completely closed, although the cover body 80 can play a certain anti-leakage effect, However, it cannot be completely avoided. When the second housing 91 is provided with the second sealing ring 93, since the second sealing ring 93 seals the gap between the second housing 91 and the connector 37, if the cover 80 and the first The second housing 91 adopts a non-detachable connection, that is, a common fixed connection. When the cover body 80 is rotated, the second sealing ring 93 will inevitably rub against the inner wall of the connecting head 37, which will greatly affect the cover body. 80 of the capping, so that the capping needs to use a larger force. Therefore, it is preferable that the cover body 80 and the second casing 91 be detachably connected, or called a movable connection. For example, in this embodiment, the upper end of the second casing 91 is provided with a rotating portion 94, and the rotating portion 94 is provided with a first The protrusion 95, the cover body 80 is provided with a connecting hole 81, the rotating part 94 can be inserted into the connecting hole 81 and buckled on the connecting hole 81 through the first protrusion 95, so that the second shell 91 can be connected to the connecting hole 81. In this design, when the cover body 80 covers the connecting head 37, due to the existence of the second sealing ring 93, the second housing 91 will move up and down equivalent to the connecting head 37, and almost no rotation will occur, while The second casing 91 is equivalent to the rotation of the cover body 80 , which can make the cover body 80 easy to cover and close, and at the same time, the second sealing ring 93 can play a better anti-leakage effect.

protection element

The storage cavity 90 can be connected to the connecting head 37 through the cover body 80. For example, in this embodiment, the cover body 80 and the connecting head 37 are connected by threaded fitting, and the cover body 80 can be fixed to the connecting head by gently twisting the cover body 80 several times. 37, but at this time, the cover body 80 is easy to fall off from the connector 37 because the number of turns on the cover body 80 is not large. At this time, it is easy to cause the sharp part 38 to pierce the sealing film 92 . It is very difficult to find a position where the cover 80 will not fall off and the storage cavity 90 inside will not be punctured, and even if this position is found, the inspector will not know how to operate the inspection device. It is also easy to perform misoperation. For example, the cover body 80 is accidentally tightened before the detection, which causes the sealing film 92 to be punctured, and then the buffer is released into the collection chamber 22, which will breed after being exposed to the collection chamber 22 for a long time. Bacteria and their metabolites can change the pH of the buffer, resulting in inaccurate test results.

In order to solve this technical problem, the detection device further includes a protection element 70, which is used to limit the excessive rotation of the cover body 80, that is, to limit the sharp part 38 from piercing the storage cavity 90, the protection element 70 includes a support section 71, and the support section 71 covers On the connector 37 , the lower end of the support section 71 abuts against the upper surface of the cover end 31 , and the upper end of the support section 71 abuts against the cover body 80 , which can prevent the cover body 80 from rotating excessively. The support section 71 can be hollow cylindrical, which can be sleeved on the connecting head 37 in a sleeved manner. Further, when the support section 71 is a hollow cylindrical shape, if the sharp part 38 needs to pierce the storage cavity 90, the cover body 80 should be unscrewed first, then the protective element 70 should be removed, and then the cover body 80 should be screwed tightly. Such an operation is too cumbersome. In this embodiment, the support section 71 of the protective element 70 is provided with a first gap 72, and the protective element 70 is elastic and can be elastically deformed, so that the protective element 70 can be directly removed without the need to unscrew the cover body 80. When the element 70 is removed, it is convenient to directly rotate the cover body 80 to pierce the storage cavity 90 .

Preferably, in order to facilitate the removal of the protective element 70 , the protective element 70 further includes a grip portion 73 , and the grip portion 73 is provided with stripes, which can increase the frictional force between the inspector and the grip portion 73 . Further, the position of the gripping portion 73 is connected to the support section 71 , and the connection position of the gripping portion 73 and the support section 71 is just opposite to the first gap 72 .

Preferably, in order to make the protection element 70 more firmly installed on the connector 37, the protection element 70 is provided with a second protrusion 44 protruding inwardly at the bottom position of the support section 71, and the second protrusion 44 may be annular. Correspondingly, the connecting head 37 is also provided with an annular structure 42 near the bottom, and the second protrusion 44 can be snapped into the gap between the annular structure 42 and the upper surface of the cover end 31, so that the protection element 70 can be securely installed. .

Preferably, in order to make the detection device beautiful, the position of the holding portion 73 on the protective element 70 is correct, rather than randomly oriented. The inner side of the segment 71 is provided with a third protrusion 74 facing the first notch 72. The third protrusion 74 can be inserted into the second notch 45, so that the rotation of the protection element 70 on the connector 37 can be restricted. When the second notch 45 is located close to the long side of the cover end 31 , the holding portion 73 of the protection element 70 is also located near the long side of the cover end 31 , as shown in FIG. 1 .

When the protection element 70 is installed on the connector 37, the support section 71 of the protection element 70 can prevent the cover body 80 from being screwed in excessively, but cannot restrain the cover body 80 from being screwed out. Afterwards, the cover body 80 can still be unscrewed, so the inspector does not know whether to remove the protective element 70 or unscrew the cover body 80 first without knowing how to use the inspection device. Preferably, the support section 71 of the protection element 70 is provided with a blocking wall 75. The blocking wall 75 corresponds to the shape of the supporting section 71 and is also arc-shaped, because during the use of the detection device, the cover body 80 will be pressed against the supporting section. The upper end of 71, so the inner diameter of the position of the baffle wall 75 is slightly larger than the inner diameter of the position of the support section 71, the inner side of the baffle wall 75 is provided with a buckle 76, correspondingly, the bottom position of the cover body 80 is provided with a ring of flanges 82, the cover body 80 The flange 82 can enter into the blocking wall 75 and be buckled under the buckle 76 . Further, the upper end of the flange 82 is horizontal, and the lower end surface of the buckle 76 is also horizontal. After the cover body 80 is installed, the upper end of the flange 82 abuts or nearly abuts with the lower end surface of the buckle 76 . At this time, if the inspector wants to unscrew the cover body 80, the flange 82 of the cover body 80 abuts against the buckle 76, the buckle 76 drives the protection element 70 to move upward, and the second protrusion of the protection element 70 44 is in the state of being buckled between the annular structure 42 and the cover end 31 at this time, so that the protection element 70 cannot complete the upward movement, so the cover body 80 cannot be unscrewed. Such a structural design allows the inspector to pull out the protective element 70 first when using the inspection device. After pulling out the protective element 70, only the cover body 80 remains on the inspection device. At this time, the inspector rotates the cover body 80 to release the The buffer solution is a matter of course/goes with the flow, and the testing personnel do not need to know how to use the testing device in advance. It is obvious to the testing personnel how to use the device for testing.

Preferably, the upper end of the buckle 76 is inclined, and the lower side of the flange 82 of the cover body 80 is provided with a chamfer 83, so that during the production and assembly of the detection device, the assembler first sets the protective element 70 to the connector 37. Then, screw the cover 80 on the connector 37, and the cover 80 (the second shell 91 has been installed inside the cover 80) is downward During the movement, the chamfer 83 of the flange 82 is in contact with the upper end surface (inclined surface) of the buckle 76, the downward movement of the cover body 80 can provide a horizontal force, and this horizontal force can slightly stretch the protective element 70, Until the buckle 76 is snapped onto the flange 82 of the cover body 80 . At this time, when the cover body 80 is reversely rotated, since the upper end of the flange 82 and the lower end surface of the buckle 76 are both horizontal planes, a horizontal force cannot be generated between them, so the protection element 70 cannot be stretched, and the locking is realized. The purpose of the cover body 80 .

The above are only specific embodiments of the invention, but the protection scope of the invention is not limited to this. Any changes or replacements that are not thought of without creative work should be covered within the protection scope of the invention. Therefore, the protection of the invention The scope should be subject to the protection scope defined by the claims.

The invention shown and described herein may be practiced in the absence of any element, limitation, specifically disclosed herein. The terms and expressions employed are to be used as terms of description rather than limitation and it is not intended that the use of these terms and expressions exclude any equivalents of the features shown and described, or parts thereof, and it should be recognized that each Both modifications are possible within the scope of the present invention. It should therefore be understood that while the invention has been specifically disclosed by various embodiments and optional features, modifications and variations of the concepts described herein may be employed by those of ordinary skill in the art and are considered to fall within the scope of It is within the scope of the invention as defined in the appended claims.

The contents of articles, patents, patent applications, and all other documents and electronically available information described or recorded herein are hereby incorporated by reference in their entirety to the same extent as if each individual publication was specifically As if indicated separately for reference. Applicants reserve the right to incorporate into this application any and all materials and information from any such articles, patents, patent applications or other documents.

Claims (36)

1. A detection device comprising a storage chamber, wherein an additive is present in the storage chamber, wherein a pointed portion is present in the detection device, wherein the storage chamber is movable relative to the pointed portion, and wherein during movement of the storage chamber is pierced by the pointed portion, thereby releasing the additive from the storage chamber.

2. The detecting device for detecting the rotation of a motor rotor according to claim 1, further comprising a collecting chamber into which the released additive can enter.

3. The testing device as claimed in claim 2, wherein the collection chamber is used for containing the sample, the collection chamber is disposed in the first housing, and the first housing is provided with an opening at an upper side thereof.

4. A test device according to claim 2, wherein the collection chamber is provided with a test element for detecting the analyte.

5. A testing device according to claim 3, wherein the test element is provided on a carrier, the carrier having a specific mating form with the collection chamber, the carrier being insertable into the collection chamber from an opening at an upper side position of the first housing, the carrier having a defined, unique orientation position when inserted into the collection chamber.

6. The detecting device for detecting the rotation of a motor rotor as claimed in claim 5, wherein the collecting cavity is provided with clamping strips, a carrier is fixed through the two clamping strips, and one side of the carrier, on which the test element is arranged, is attached to the inner wall of one side of the collecting cavity.

7. The detecting device for detecting the rotation of a motor rotor as claimed in claim 6, wherein the thickness of the upper end of the clamping strip is smaller, and the thickness of the lower end of the clamping strip is larger; correspondingly, the thickness of the bottom position of the carrier is smaller, and the thickness of the top position of the carrier is larger.

8. The detecting device for detecting the rotation of a motor rotor as claimed in claim 5, wherein the corner positions of the collecting cavities are provided with round corners; correspondingly, both sides of the surface of the carrier on which the test element is mounted are also provided with round corners.

9. The test device of claim 3, further comprising a sample collector for collecting the sample, the sample collector comprising a capped end, the capped end operable to cap the opening of the collection chamber.

10. The test device of claim 1, wherein the sample collector further comprises a sampling end and a body, the sampling end is connected to the absorbent member, the body is adapted to connect the cap end to the sampling end, and the body is removably connected to the cap end.

11. A test device according to claim 9, wherein the sample collector and/or the collection chamber is provided with an aperture which allows the collection chamber to be in gaseous communication with the environment.

12. A test device according to claim 11 wherein the blind end is provided with a hollow tube extending in the direction of the collection chamber at the location of the aperture.

13. A test device according to claim 11 wherein the diameter of the bore is less than 1 mm.

14. The testing device of claim 1, wherein the additive in the reservoir is a buffer.

15. The test device of claim 9, wherein the sample collector has a connector at a side of the cap opposite the body, the connector being hollow and the storage chamber being accessible at the hollow.

16. A testing device according to claim 15 wherein the sharpened portion is in the form of a projection which is received in a hollow portion of the connector.

17. A testing device according to claim 16 wherein the reservoir is provided in the second housing, the second housing being provided with a sealing membrane for sealing the additive within the reservoir, the reservoir being accessible from the hollow location of the connector, the sharp portion being capable of piercing the sealing membrane of the second housing to release the additive from the reservoir.

18. The detecting device for detecting the rotation of a motor rotor as claimed in claim 16, wherein the pointed portion is provided with a through hole which penetrates up and down.

19. A testing device according to claim 17 wherein the second housing is provided with a second sealing ring which fills a gap between the second housing and the connector.

20. The testing device of claim 17, further comprising a cover, wherein the cover is removably attached to the second housing.

21. The detecting device for detecting the rotation of a motor rotor as claimed in claim 20, wherein the cover body and the connecting head can be mutually covered.

22. The detecting device for detecting the rotation of a motor rotor as claimed in claim 21, wherein the cover body and the connecting head are provided with mating threads.

23. The detecting device for detecting the rotation of a motor rotor as claimed in claim 20, wherein the cover body and the second housing are provided with a rotating portion at the upper end of the second housing, the rotating portion is provided with a first protrusion, the cover body is provided with a connecting hole, and the rotating portion can be inserted into the connecting hole and buckled on the connecting hole through the first protrusion, so that the second housing can rotate on the connecting hole.

24. A testing device according to claim 20 wherein the testing device further comprises a protective element for limiting over-closure of the cover.

25. The detecting device for detecting the rotation of a motor rotor as claimed in claim 24, wherein the protecting element comprises a supporting section, the supporting section is sleeved on the connecting head, the lower end of the supporting section can be abutted against the upper surface of the covering end, and the upper end of the supporting section can be abutted against the cover body.

26. The detecting device for detecting the rotation of a motor rotor as claimed in claim 25, wherein the supporting section has a hollow cylindrical shape and is fitted over the connecting head.

27. A testing device according to claim 25 wherein the support section of the protective member is provided with a first notch.

28. A testing device according to claim 24 wherein the protective member is resilient.

29. The detecting device for detecting the rotation of a motor rotor as claimed in claim 27, wherein the protecting member further comprises a holding portion, the holding portion is provided with stripes, the holding portion is connected with the supporting section, and the connecting position of the holding portion and the supporting section is just opposite to the first notch.

30. A testing device according to claim 25, wherein the protection member is provided with a second protrusion protruding inwardly at a bottom portion of the support section, the second protrusion is ring-shaped, and correspondingly, the connector is provided with a ring-shaped structure at a position near the bottom portion, and the second protrusion can be snapped into a gap between the ring-shaped structure and the upper surface of the cap end.

31. A testing device according to claim 30, wherein the ring-shaped structure is provided with a second notch, and correspondingly, the inner side of the supporting section of the protection member is provided with a third protrusion facing the first notch, and the third protrusion can be inserted into the second notch.

32. The detecting device for detecting the rotation of a motor rotor as claimed in claim 31, wherein the covering end is rectangular and the second notch is located at a side close to the long side of the covering end.

33. The detecting device for detecting the rotation of a motor rotor as claimed in claim 26, wherein the supporting section of the protective member is provided with a blocking wall which is arc-shaped.

34. A testing device according to claim 33 wherein the inner diameter of the protective member at the location of the abutment wall is greater than the inner diameter of the protective member at the location of the support section.

35. The detecting device for detecting the rotation of a motor rotor as claimed in claim 33, wherein the inside of the blocking wall is provided with a buckle, the bottom of the cover body is provided with a circle of flanges, and the flanges of the cover body can enter the blocking wall and be buckled below the buckle.

36. A testing device according to claim 35 wherein the upper end of the flange is horizontal and the lower end surface of the latch is horizontal; the upper end of the buckle is in an inclined plane shape, and a chamfer is arranged at the lower side position of the flange of the cover body.

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