CN114947133A - Composition containing bacillus coagulans and used for improving gastrointestinal tract health and application thereof - Google Patents
Composition containing bacillus coagulans and used for improving gastrointestinal tract health and application thereof Download PDFInfo
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- CN114947133A CN114947133A CN202210411468.4A CN202210411468A CN114947133A CN 114947133 A CN114947133 A CN 114947133A CN 202210411468 A CN202210411468 A CN 202210411468A CN 114947133 A CN114947133 A CN 114947133A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention relates to a composition for improving gastrointestinal tract health (IPC code: A23L1/29), in particular to a composition containing bacillus coagulans for improving gastrointestinal tract health and application thereof. The raw materials at least comprise the following components in percentage by weight: 40-60% of L-arabinose, 7-20% of xylo-oligosaccharide, 5-10% of skimmed milk powder, 6-24% of oligosaccharide, 2-8% of chicory extract, 1-5% of tuna peptide powder, 1-3% of bacillus coagulans and 0.1-1% of edible essence. Therefore, the invention uses oligosaccharide as main component, and through adding bacillus coagulans and tuna peptide powder, improves the intestinal micro-ecological environment, promotes gastrointestinal tract peristalsis, loosens the bowel to relieve constipation, effectively regulates defecation time, achieves the purpose of treating constipation, accelerates the excretion of uric acid, can prevent ventilation, meets the requirements of basic physiological functions and metabolism of human body, and can promote human health.
Description
Technical Field
The invention relates to a composition for improving gastrointestinal tract health (IPC code: A23L1/29), in particular to a composition containing bacillus coagulans for improving gastrointestinal tract health and application thereof.
Background
With the continuous development of Chinese economy and the improvement of the living standard of residents, the dietary nutrition condition of residents in urban and rural areas of China is obviously improved, and the prevalence rate of malnutrition and nutrient deficiency is continuously reduced. However, at the same time, China also faces the double challenges of nutrient deficiency and nutrient structure imbalance, and particularly, chronic diseases and sub-health are on an increasing trend. Health problems have become increasingly prominent and a social topic, and the demand for health has risen rapidly from basic disease prevention to better "feel" and "image". Functional foods have come to the end, and their production and consumption have also progressed rapidly.
The bacillus coagulans has the health-care effects of lactic acid bacteria and bifidobacteria, and also has the characteristics of acid resistance, heat resistance, salt resistance, easy culture, easy storage and promotion of growth and propagation of probiotics such as intestinal bifidobacteria and the like, so that the bacillus coagulans can be successfully propagated in the environment with low pH value (stomach) and high bile salt (intestine) to form dominant flora.
Therefore, the invention uses oligosaccharide as main component, and through adding bacillus coagulans and tuna peptide powder, improves intestinal micro-ecological environment, promotes gastrointestinal tract peristalsis, loosens the bowel to relieve constipation, effectively regulates defecation time, thereby achieving the purpose of treating constipation, accelerates the excretion of uric acid, can prevent ventilation, meets the requirements of basic physiological functions and metabolism of human body, can promote human health, can effectively relieve the moisture absorption caking problem of the polypeptide composition, and improves the storage stability of the product.
Disclosure of Invention
In order to solve the above problems, a first aspect of the present invention provides a composition for improving gastrointestinal health comprising bacillus coagulans, which comprises, in weight percent, at least: 40-60% of L-arabinose, 7-20% of xylo-oligosaccharide, 5-10% of skimmed milk powder, 6-24% of oligosaccharide, 2-8% of chicory extract, 1-5% of tuna peptide powder, 1-3% of bacillus coagulans and 0.1-1% of edible essence.
As a preferred embodiment, the composition for improving gastrointestinal health containing bacillus coagulans comprises the following raw materials by weight percent: 45-55% of L-arabinose, 10-15% of xylo-oligosaccharide, 7-8% of skimmed milk powder, 10-20% of oligosaccharide, 4-6% of chicory extract, 2-4% of tuna peptide powder, 1-3% of bacillus coagulans and 0.1-1% of edible essence.
As a preferable scheme, the weight ratio of the L-arabinose to the xylo-oligosaccharide is (3.5-4.5): 1.
as a preferable scheme, the weight ratio of the L-arabinose to the xylo-oligosaccharide is 4: 1.
in a preferred embodiment, the main component of the tuna peptide powder is anserine.
Preferably, the effective component of the anserine is more than or equal to 99%.
Preferably, the molecular weight of the tuna peptide powder is 200-300 Da.
In a preferred embodiment, the molecular weight of the tuna peptide powder is 240 Da.
Tuna peptide powder is prepared from tuna as a raw material, small molecular peptide substances obtained by enzymolysis and small molecular active peptide substances obtained by enzyme grafting. The applicant shows through research that anserine with the molecular weight of 200-300 Da has the effect of enhancing the activity of Lactate Dehydrogenase (LDH), can rapidly decompose lactic acid in vivo, leaves an enough channel for discharging uric acid, avoids the formation of crystals, can obviously improve the activity of hypoxanthine-guanine phosphoribosyl transferase (HGPRT), and can indirectly reduce the uric acid level when the activity of HGPRT is enhanced.
In a preferred embodiment, the oligosaccharide is one or more of isomaltooligosaccharide, galactooligosaccharide and fructooligosaccharide.
In a preferred embodiment, the oligosaccharide is a mixture of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides.
Preferably, the fructooligosaccharide has a pH of 4.5 to 7.0 and is commercially available, for example, fructooligosaccharide 95 powder (FOS95 powder) from bowling Biotin GmbH.
The fructo-oligosaccharide is prepared by taking sucrose as a raw material and performing enzymolysis and purification, the fructosyl is connected by beta (2 → 1) glycosidic bond, and the functional oligosaccharide with the polymerization degree of 2-9 can effectively proliferate beneficial bacteria.
Preferably, the weight ratio of the isomaltooligosaccharide to the galactooligosaccharide to the fructooligosaccharide is (3-6): (4-5): (4-6).
In a preferable scheme, the oligosaccharide is prepared from bacillus coagulans in a weight ratio of (6-8): 1.
as a preferable scheme, the weight ratio of bacillus coagulans to the tuna peptide powder is (2-4): 2.
in a preferred embodiment, the weight ratio of the tuna peptide powder to the bacillus coagulans is 3: 2.
as a preferred embodiment, the chicory extract is long-chain inulin; the polymerization degree of the long-chain inulin is 32-34, and the long-chain inulin can be sold in markets, such as Shanxi Hao Chen Biotechnology GmbH.
The herba Cichorii extract can effectively reduce serum Total Cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), increase high density lipoprotein/low density lipoprotein ratio, and improve blood lipid condition. Many dietary fibers reduce blood lipid levels by absorbing intestinal fat, forming fat-fiber complexes that are carried out with the stool. Furthermore, inulin is itself fermented to short chain fatty acids and lactate, which are regulators of liver metabolism, before it ends up in the intestine. Short chain fatty acids (acetate and propionate) are used as fuel in the blood, and propionate inhibits cholesterol synthesis.
As a preferable scheme, the oligosaccharide and the chicory extract are in a weight ratio of (2-4): 1.
as a preferred embodiment, the weight ratio of oligosaccharide, chicory extract is 3: 1.
in a second aspect, the present invention provides a method for preparing a composition for improving gastrointestinal health comprising bacillus coagulans, comprising the steps of: and uniformly mixing L-arabinose, xylo-oligosaccharide, skim milk powder, oligosaccharide, a chicory extract, tuna peptide powder, bacillus coagulans and edible essence to obtain the composition containing the bacillus coagulans and improving the gastrointestinal health.
Has the advantages that:
1. the invention utilizes the synergistic effect of L-arabinose and xylo-oligosaccharide, and when the weight ratio of the L-arabinose to the xylo-oligosaccharide is (3.5-4.5): 1, the bifidobacterium can be effectively promoted to generate a large amount of short-chain fatty acids, intestinal peristalsis can be stimulated, intestinal peristalsis is increased, concentration difference is formed, water around the intestines is absorbed into the large intestine under the action of osmotic pressure, and the water content of the intestinal tract is increased.
2. According to the invention, through anserine with the molecular weight of 200-300 Da, lactic acid in vivo can be rapidly decomposed, an enough channel is reserved for discharging uric acid, the formation of crystals is avoided, the activity of hypoxanthine-guanine phosphoribosyl transferase (HGPRT) can be obviously improved, and when the activity of HGPRT is enhanced, the uric acid level can be indirectly reduced.
3. According to the invention, through the synergistic effect of isomaltooligosaccharide, galactooligosaccharide, fructooligosaccharide and bacillus coagulans, the bacillus coagulans is used as probiotics, so that the lactobacillus coagulans has the characteristic of producing lactic acid, has rich enzyme system of the bacillus and the characteristics of strong stress resistance, high temperature and high pressure resistance and stable storage, and simultaneously, the isomaltooligosaccharide and the galactooligosaccharide provide nutrient components for the bacillus coagulans, so that the durability of the bacillus coagulans is improved, and meanwhile, the isomaltooligosaccharide, the fructooligosaccharide and the galactooligosaccharide are fermented to produce acid without producing gas.
4. According to the invention, the weight ratio of bacillus coagulans is (2-3): 2, the microecological ecological balance of the human body is effectively maintained, and the health of the human body is effectively conditioned.
5. According to the invention, the chicory extract with the polymerization degree of 32-34 is prepared from oligosaccharide in a weight ratio of (2-4): 1, can meet the basic physiological function and metabolism requirement of human body, can promote human health, and can effectively alleviate the moisture absorption and agglomeration problem of the polypeptide composition, thereby improving the low-temperature storage stability of the product.
Detailed Description
Examples
Example 1
Example 1 of the present invention provides a composition for improving gastrointestinal health comprising bacillus coagulans, which comprises the following raw materials in percentage by weight: 52% of L-arabinose, 12% of xylo-oligosaccharide, 8% of skim milk powder, 16% of oligosaccharide, 6% of chicory extract, 3% of tuna peptide powder, 2% of bacillus coagulans and 1% of edible essence.
In the embodiment, the tuna peptide powder comprises anserine; the molecular weight of the anserine is 240 Da.
In this example, the oligosaccharide is a mixture of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides. The weight ratio of the isomaltooligosaccharide to the galactooligosaccharide to the fructooligosaccharide is 5: 4: 5.
in this example, the chicory extract is long-chain inulin; the polymerization degree of the long-chain inulin is 33.
In this example, the L-arabinose was purchased from Jinan Shengquan Tang and Tang Biotech, Inc.; the xylo-oligosaccharide is purchased from bowling biological shares, Inc.; the skim milk powder was purchased from Biotech limited, Bobei (Guangdong); the isomaltooligosaccharide is purchased from Jiangsu Xiaizhuo food science and technology company Limited; the galactooligosaccharides are purchased from quantum gaku (guangdong) bio ltd; the fructo-oligosaccharide is purchased from fructo-oligosaccharide 95 powder (FOS95 powder) from bowling bio-products limited; the chicory extract is purchased from Shanxi Hao Chen Biotech limited; the tuna peptide powder is purchased from Zhaoqing Xingyi ocean bioengineering, Inc.; the bacillus coagulans was purchased from mitsubishi chemical corporation; the edible essence is purchased from Zhenxin essence and spice limited company in Guangzhou city.
In a second aspect, this embodiment provides a method for preparing a composition comprising bacillus coagulans for improving gastrointestinal health, comprising the steps of: and uniformly mixing L-arabinose, xylo-oligosaccharide, skim milk powder, oligosaccharide, a chicory extract, tuna peptide powder, bacillus coagulans and edible essence to obtain the composition containing the bacillus coagulans and improving the gastrointestinal health.
Example 2
Example 2 of the present invention provides a composition for improving gastrointestinal health comprising bacillus coagulans, which comprises the following raw materials by weight: 52.5 percent of L-arabinose, 15 percent of xylo-oligosaccharide, 8 percent of skim milk powder, 5 percent of isomalto-oligosaccharide, 4 percent of galacto-oligosaccharide, 5 percent of fructo-oligosaccharide, 5 percent of chicory extract, 3 percent of tuna peptide powder, 2 percent of bacillus coagulans and 0.5 percent of edible essence.
In the embodiment, the tuna peptide powder comprises anserine; the molecular weight of the anserine is 240 Da.
In this example, the oligosaccharide is a mixture of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides. The weight ratio of isomaltooligosaccharide to galactooligosaccharide to fructooligosaccharide is 5: 5: 5.
in this example, the chicory extract is long-chain inulin; the polymerization degree of the long-chain inulin is 33.
In this example, the L-arabinose was purchased from Jinan Shengquan Tang and Tang Biotech, Inc.; the xylo-oligosaccharide is purchased from bowling biological shares, Inc.; the skim milk powder was purchased from Biotech, Inc., Boehringer (Guangdong); the isomaltooligosaccharide is purchased from Jiangsu Xiaizhuo food science and technology company Limited; the galactooligosaccharides are purchased from quantum gaku (guangdong) bio ltd; the fructo-oligosaccharide is purchased from fructo-oligosaccharide 95 powder (FOS95 powder) from bowling bio-products limited; the chicory extract is purchased from Shanxi Hao Chen Biotech limited; the tuna peptide powder is purchased from Zhaoqing Xingyi ocean bioengineering, Inc.; the bacillus coagulans was purchased from mitsubishi chemical corporation; the edible essence is purchased from Zhenxin essence and spice limited company in Guangzhou city.
In a second aspect, this embodiment provides a method for preparing a composition comprising bacillus coagulans for improving gastrointestinal health, comprising the steps of: and uniformly mixing L-arabinose, xylo-oligosaccharide, skim milk powder, oligosaccharide, a chicory extract, tuna peptide powder, bacillus coagulans and edible essence to obtain the composition containing the bacillus coagulans and improving the gastrointestinal health.
Example 3
Example 3 of the present invention provides a composition for improving gastrointestinal health comprising bacillus coagulans, which comprises the following raw materials by weight: 52.5 percent of L-arabinose, 15 percent of xylo-oligosaccharide, 8 percent of skim milk powder, 5 percent of isomalto-oligosaccharide, 4 percent of galacto-oligosaccharide, 7 percent of fructo-oligosaccharide, 4 percent of chicory extract, 3 percent of tuna peptide powder, 1 percent of bacillus coagulans and 0.5 percent of edible essence.
In the embodiment, the tuna peptide powder comprises anserine; the molecular weight of the anserine is 240 Da.
In this example, the oligosaccharide is a mixture of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides. The weight ratio of isomaltooligosaccharide to galactooligosaccharide to fructooligosaccharide is 5: 5: 5.
in this example, the chicory extract is long-chain inulin; the polymerization degree of the long-chain inulin is 33.
In this example, the L-arabinose was purchased from Jinan Shengquan Tang and Tang Biotech, Inc.; the xylo-oligosaccharide is purchased from bowling biological shares, Inc.; the skim milk powder was purchased from Biotech limited, Bobei (Guangdong); the isomaltooligosaccharide is purchased from Jiangsu Xiaizhuo food science and technology company Limited; the galactooligosaccharides are purchased from quantum gaku (guangdong) bio ltd; the fructo-oligosaccharide is purchased from fructo-oligosaccharide 95 powder (FOS95 powder) from bowling bio-products limited; the chicory extract is purchased from Shanxi Hao Chen Biotech limited; the tuna peptide powder is purchased from Zhaoqing Xingyi ocean bioengineering, Inc.; the bacillus coagulans was purchased from mitsubishi chemical corporation; the edible essence is purchased from Zhenxin essence and spice limited company in Guangzhou city.
In a second aspect of this embodiment, there is provided a method for preparing a composition for improving gastrointestinal health comprising bacillus coagulans, comprising the steps of: and uniformly mixing L-arabinose, xylo-oligosaccharide, skim milk powder, oligosaccharide, a chicory extract, tuna peptide powder, bacillus coagulans and edible essence to obtain the composition containing the bacillus coagulans and improving the gastrointestinal health.
And (3) performance testing:
(1) low-temperature storage stability: the gastrointestinal health improving composition containing bacillus coagulans in examples 1-3 was stored at-5 ℃ for 12 months and at-5 ℃ for observing whether the product has caking and flocculation, and the low-temperature storage stability was scored as 0-10 points, wherein 0 point represents caking and flocculation, 10 points represents no caking and flocculation, and the higher the score is, the better the low-temperature storage stability is, and the experimental results are shown in table 1.
(2) High-temperature storage stability: the gastrointestinal health improving compositions of examples 1 to 3 containing Bacillus coagulans were stored at 50 ℃ for 12 months, and the products were observed for discoloration and discoloration/higher score/higher score/higher temperature storage stability/higher temperature storage/higher storage stability/higher storage ratio/higher storage period in each storage period of the results of each indicated in Table 1/higher storage period in the results in the storage period of each of the results shown in Table 1, and higher storage period of each of examples in Table 1.
And (3) performance test results:
table 1 shows the results of the performance tests of the compositions for improving gastrointestinal health comprising Bacillus coagulans prepared in examples 1-3.
TABLE 1
| High temperature storage stability | Low temperature storage stability | |
| Example 1 | 10 | 10 |
| Example 2 | 10 | 9 |
| Example 3 | 9 | 10 |
Claims (10)
1. A composition containing bacillus coagulans and used for improving gastrointestinal tract health is characterized in that the raw materials comprise, by weight: 40-60% of L-arabinose, 7-20% of xylo-oligosaccharide, 5-10% of skimmed milk powder, 6-24% of oligosaccharide, 2-8% of chicory extract, 1-5% of tuna peptide powder, 1-3% of bacillus coagulans and 0.1-1% of edible essence.
2. The gastrointestinal health improving composition according to claim 1, wherein the raw materials comprise, in weight percent: 45-55% of L-arabinose, 10-15% of xylo-oligosaccharide, 7-8% of skimmed milk powder, 10-20% of oligosaccharide, 4-6% of chicory extract, 2-4% of tuna peptide powder, 1-3% of bacillus coagulans and 0.1-1% of edible essence.
3. The gastrointestinal health improving composition according to any one of claims 1 to 2, wherein the weight ratio of the L-arabinose to the xylo-oligosaccharide is (3.5-4.5): 1.
4. gastrointestinal health improving composition according to any of claims 1-2, wherein the oligosaccharides are one or more of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides.
5. The gastrointestinal health improving composition according to claim 4, wherein the oligosaccharide is a mixture of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides.
6. The gastrointestinal health improving composition according to claim 5, wherein the weight ratio of isomaltooligosaccharides, galactooligosaccharides and fructooligosaccharides is (3-6): (4-5): (4-6).
7. The gastrointestinal health improving composition according to any one of claims 1 to 2, wherein the weight ratio of the tuna peptide powder to the bacillus coagulans is (2-4): 2.
8. gastrointestinal health improving composition according to any of claims 1-2, wherein the weight ratio of oligosaccharide, chicory extract is (2-4): 1.
9. the gastrointestinal health improving composition of claim 8, wherein the oligosaccharide, chicory extract, is present in a weight ratio of 3: 1.
10. use of a composition according to any one of claims 1 to 9 for improving gastrointestinal health in a human for the preparation of a food product for improving gastrointestinal tract in a human.
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