CN115083883A - Ion transmission device and ion transmission method - Google Patents

Abstract

The embodiment of the invention provides an ion transmission device and an ion transmission method, and relates to the technical field of ion optics. The ion transmission device is based on a radio frequency multipole ion guide/linear ion trap, a radio frequency multipole ion guide branch is arranged on a radio frequency multipole ion guide main circuit, the radio frequency multipole ion guide branch is used as an axial branch of the radio frequency multipole ion guide main circuit, the axial directions of the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are all divided into a plurality of sections, different and variable voltages are applied through the sections to form axial potential wells, the ion position is accurately controlled, ions can be introduced through axial ports on the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch, and the ions are extracted through axial ports and radial extraction ports on the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch. The flexible connection of more upstream devices and more downstream devices is realized, and the method has a good application prospect.

Description

Ion transmission device and ion transmission method

technical field

The present invention relates to the technical field of ion optics, and in particular, to an ion transmission device and an ion transmission method.

Background technique

Mass spectrometry instruments are a class of instruments that ionize samples and measure the mass-to-charge ratio and abundance of the generated ions, and are widely used in the analysis of material composition in various fields. Specifically, the sample is introduced into the ion source by the sampling system, and is ionized into ions by the ion source; the ions are transmitted to the mass analyzer through the ion transmission device, and the mass analyzer is separated and the mass is measured. Ion source is the most important part of mass spectrometry instrument, there are many kinds, such as electrospray ionization source, electron ionization source, inductively coupled plasma ionization source, etc., involving different ionization principles, different mechanical structures, different use conditions, and have different performances, Therefore, it has different application areas. Mass analyzers are the core of mass spectrometry instruments, and there are many types, such as time-of-flight mass analyzers, quadrupole mass analyzers, ion trap mass analyzers, etc., involving different mass analysis principles, different working conditions, and different performances. scope of application.

Usually, a single mass spectrometer has only a single ion source and a single mass analyzer, which can only achieve a certain range of applications. With the development of science and technology and the improvement of people's livelihood, the requirements for mass spectrometry instruments have been continuously improved, and a single mass spectrometer instrument integrated with multiple ion sources or multiple mass analyzers has become a kind of development direction: the complex system involves abundant analytical species, A variety of ion sources are required for batch ionization to achieve comprehensive analysis; in addition to the normal ion source, some high-precision mass spectrometry instruments also need to couple additional ion sources to generate reference ions to achieve real-time or periodic calibration.

The integration of multiple ion sources or multiple mass analyzers is specifically realized through an ion transmission device, but the existing ion transmission device cannot flexibly couple the upstream device and the downstream device, and has a single ion control function.

SUMMARY OF THE INVENTION

The object of the present invention is to provide an ion transport device and an ion transport method, which can realize flexible connection of multiple upstream devices and multiple downstream devices through one unit structure.

Embodiments of the present invention can be implemented as follows:

In a first aspect, the present invention provides an ion transmission device, comprising a radio frequency multipole ion guide main circuit and a radio frequency multipole ion guide branch, and the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are both linear radio frequency multipoles. Polar ion guide, RF multipole ion guide main circuit and RF multipole ion guide branch all have two axial ports arranged oppositely, one or two axial ports of RF multipole ion guide branch and RF multipole ion guide main The circuit is connected to serve as an axial branch of the main circuit of the radio frequency multipole ion guide;

The axial direction of the RF multipole ion guide main circuit and the RF multipole ion guide branch is divided into multiple sections, so as to form an axial potential well by applying different and variable voltages to each section;

A radial lead-out port is provided on the radio frequency multipole ion guide main circuit and/or the radio frequency multipole ion guide branch.

In an optional embodiment, there are multiple radio frequency multipole ion guide branches, and the communication points between the multiple radio frequency multipole ion guide branches and the radio frequency multipole ion guide main path are located in the same section or different from the radio frequency multipole ion guide main path The extension directions of the plurality of radio frequency multipole ion guiding branches are the same or different.

In an optional embodiment, the radio frequency multipole ion guide branch is further communicated with a second radio frequency multipole ion guide branch, and the second radio frequency multipole ion guide branch has two axial ports arranged oppositely. One or two axial ports of the ion guide branch communicate with the radio frequency multipole ion guide branch to serve as an axial branch of the radio frequency multipole ion guide branch;

A third-stage RF multipole ion guide branch is also connected to the second-stage RF multipole ion guide branch, so that the third-stage RF multipole ion guide branch is used as the axial branch of the second-stage RF multipole ion guide; the third-stage RF multipole ion guide branch is The ion guide branch is also connected with a four-stage radio frequency multipole ion guide branch, and so on, to form a multi-stage branch structure, and each stage branch serves as an axial branch of the previous stage branch.

In an optional embodiment, both the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are radio frequency multipoles.

In an optional embodiment, the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are both radio frequency quadrupoles, and both the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch include two oppositely arranged second A strip electrode and two oppositely arranged second strip electrodes are used to form a linear radio frequency quadrupole ion guiding structure by using the two first strip electrodes and the two second strip electrodes;

Both of the two first strip electrodes are divided into a plurality of block electrodes, and the plurality of block electrodes on one first strip electrode are arranged opposite to the plurality of block electrodes on the other first strip electrode, The radial outlet is located on the bulk electrode.

In a second aspect, the present invention provides an ion transmission method, which applies the ion transmission device of any one of the foregoing embodiments for ion transmission, and the ion inlet comprises: an axial port;

The ion outlet includes: axial port and radial outlet;

A multipole field is formed radially inside the ion transmission device to realize radial confinement of ions; an axial potential well is formed axially inside the ion transmission device to realize the position control of ions.

In an optional embodiment, the ions are introduced into the ion transport device from the ion inlet by the upstream device, and are extracted by means of axial extraction or radial extraction;

Among them, when the axial extraction method is adopted, the ions are first controlled to stay close to the ion outlet, and by adjusting the electric potential, the ions are extracted from the ion outlet to the downstream device under the guidance of the electric field;

When the radial extraction method is adopted, the ions are first controlled to stay at the position with the radial extraction opening, and the ions are extracted from the radial extraction opening to the downstream device under the guidance of the electric field by adjusting the electric potential;

Preferably, gas is introduced into the ion transmission device, and the kinetic energy is lost due to the collision of ions with the gas, so that the ions are confined in the axial potential well; the ions are gradually focused under continuous collision cooling, and the ions are continuously implanted, confined and cooled to realize the ionization. collect.

In an alternative embodiment, ion movement is achieved by changing the position of the axial potential well;

Preferably, the dispersion of the ions is realized by the following method: the ions are gathered at the first position through the axial potential trap, and the electric potential of the axial confinement near the first position is controlled to be close to the first position, so that the ions are dispersed to the ions due to Coulomb repulsion. near the first position, then the potential at the first position is changed to further separate the dispersed ions.

Preferably, the following method is adopted to realize the mixing of ions: set the position to be gathered as the second position, first disperse the ions and stay near the second position, and then change the potential of the axial confinement near the second position, so that the ions are under the action of the potential Aggregation at the second location enables inter-ionic mixing.

In alternative embodiments, two or more upstream devices and two or more downstream devices, or one upstream device and two or more downstream devices, are coupled simultaneously using an ion transport device, or Two or more upstream devices and one downstream device, and the operation modes of the upstream device and the downstream device include: alternate operation in time intervals, real-time alternate operation, and mixed operation.

The beneficial effects of the embodiments of the present invention are: based on the radio frequency multipole ion guidance, the radio frequency multipole ion guidance branch is set on the radio frequency multipole ion guidance main circuit, so that the radio frequency multipole ion guidance branch is used as the main circuit of the radio frequency multipole ion guidance. Axial branch, the axial direction of the RF multipole ion guide main circuit and the RF multipole ion guide branch are divided into multiple sections to form an axial potential well by applying different and variable voltages to each section to control the ions more precisely Location, ions can be introduced through axial ports on the RF multipole ion guide main circuit and RF multipole ion guide branch, and ions can be introduced through axial ports and radial ports on the RF multipole ion guide main circuit and RF multipole ion guide branch The extraction port extracts the ions. The flexible connection of more upstream devices (such as ion sources) and more downstream devices (such as mass analyzers) is realized, which has very good application prospects.

Description of drawings

In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the following briefly introduces the accompanying drawings used in the embodiments. It should be understood that the following drawings only show some embodiments of the present invention, and therefore do not It should be regarded as a limitation of the scope, and for those of ordinary skill in the art, other related drawings can also be obtained according to these drawings without any creative effort.

1 is a schematic diagram of a first structure of an ion transport device;

Fig. 2 is the second structural schematic diagram of the ion transport device;

3 is a third structural schematic diagram of an ion transport device;

FIG. 4 is a fourth structural schematic diagram of the ion transport device;

5 is a fifth structural schematic diagram of the ion transport device;

6 is a sixth structural schematic diagram of the ion transport device;

7 is a seventh structural schematic diagram of the ion transport device;

FIG. 8 is a schematic diagram of an eighth structure of the ion transport device.

Icon: 001-RF multipole ion guide main circuit; 002-RF multipole ion guide branch; 003-axial port; 004-radial outlet; 005-secondary RF multipole ion guide branch; 101-straight plate electrode plate; 102-L-type electrode plate; 103-L-type electrode plate; 201-block electrode; 202-block electrode; 203-block electrode; 204-block electrode; 205-block electrode; 206-block electrode electrode; 207-block electrode; 208-block electrode; 209-block electrode; 210-block electrode.

Detailed ways

In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments These are some embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the drawings herein may be arranged and designed in a variety of different configurations.

Thus, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

It should be noted that like numerals and letters refer to like items in the following figures, so once an item is defined in one figure, it does not require further definition and explanation in subsequent figures.

In the description of the present invention, it should be noted that, if the terms "upper", "lower", "inner", "outer", etc. appear, the orientation or positional relationship indicated is based on the orientation or positional relationship shown in the drawings, or It is the orientation or positional relationship that the product of the invention is usually placed in use, only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation , so it should not be construed as a limitation of the present invention.

In addition, where the terms "first", "second" and the like appear, they are only used to differentiate the description, and should not be construed as indicating or implying relative importance.

It should be noted that the features in the embodiments of the present invention may be combined with each other without conflict.

1-2, an embodiment of the present invention provides an ion transmission device, including a radio frequency multipole ion guide main circuit 001 and a radio frequency multipole ion guide branch 002, a radio frequency multipole ion guide main circuit 001 and a radio frequency multipole ion guide The guide branches 002 are all linear radio frequency multipole ion guides. Based on the radio frequency multipole ion guide, the radio frequency multipole ion guide branch is added to make the ion introduction and extraction more flexible.

Figures 1 to 8 are linear radio frequency quadrupole ion guide structures, the radio frequency multipole ion guide main circuit 001 and the radio frequency multipole ion guide branch 002 both have two axial ports 003 arranged oppositely, and the radio frequency multipole ion guide branch One or two axial ports 003 of 002 are communicated with the radio frequency multipole ion guide main circuit 001 (the structure in which both axial ports 003 are communicated with the radio frequency multipole ion guide main circuit 001 is shown in Figure 4), as a radio frequency Axial branch of the multipole ion guide main circuit 001 . The RF multipole ion guide main circuit 001 and the RF multipole ion guide branch 002 are divided into multiple sections in the axial direction, so as to form an axial potential well by applying different and variable voltages to each section, and better control the stay position of the ions. The radio frequency multipole ion guide main circuit 001 and/or the radio frequency multipole ion guide branch 002 are provided with radial extraction ports 004 , so that ions can be extracted radially through the radial extraction openings 004 .

In some embodiments, there are multiple radio frequency multipole ion guide branches 002 , and the communication points of the multiple radio frequency multipole ion guide branches 002 and the radio frequency multipole ion guide main circuit 001 are located in the same segment of the radio frequency multipole ion guide main circuit 001 Or in different segments, the extension directions of the plurality of radio frequency multipole ion guiding branches 002 are the same or different. That is, a plurality of radio frequency multipole ion guiding branches 002 are located in different segment positions but in the same direction (as shown in FIG. 7 ), or in different segment locations and in different directions (as shown in FIG. 2 or FIG. 5 ), and in the same segment location but in different directions ( as shown in Figure 8). The specific number of the radio frequency multipole ion guiding branches 002 is not limited, and may be 2, 3 or more, which can be set as required.

In some embodiments, as shown in FIG. 2 , for a two-dimensional radio frequency quadrupole, part of the radio frequency multipole ion guide branch 002 communicates with one side of the radio frequency multipole ion guide main circuit 001, and another part of the radio frequency multipole ion guide branch 002 is communicated with the opposite side of the radio frequency multipole ion guide main circuit 001, and the radio frequency multipole ion guide branches 002 are arranged on both sides of the radio frequency multipole ion guide main circuit 001, so that the lead-out port can be formed in two directions , increasing the flexibility of connecting with upstream and downstream devices. For non-two-dimensional quadrupole radios, as shown in Figure 5, the attachment sites are not limited to one side and the opposite side.

In some embodiments, as shown in FIG. 3 , the radio frequency multipole ion guide branch 002 is further connected with a second radio frequency multipole ion guide branch 005 , and the second radio frequency multipole ion guide branch 005 has two oppositely arranged axial directions Port 003 , one or two axial ports 003 of the secondary RF multipole ion guide branch 005 communicate with the RF multipole ion guide branch 002 as an axial branch of the RF multipole ion guide branch 002 . By introducing secondary branches and increasing the number of ion introduction and extraction ports, the flexibility of connection with upstream and downstream devices can be further increased.

In some embodiments, a third-stage radio-frequency multipole ion-guiding branch is further connected to the second-stage radio-frequency multipole ion-guiding branch, so that the third-stage radio-frequency multipole ion-guiding branch serves as the axial direction of the second-stage radio-frequency multipole ion-guiding branch Branch; the three-stage radio frequency multipole ion guide branch is also connected with a four-stage radio frequency multipole ion guide branch, and so on to form a multi-stage branch structure, such as forming a five-stage radio frequency multipole ion guide branch, a six-stage radio frequency multipole ion guide branch Ion guiding branches, etc., each level branch acts as an axial branch of the previous level branch.

1-6 are all radio frequency quadrupole structures. In fact, the radio frequency multipole ion guide main circuit 001 and the radio frequency multipole ion guide branch 002 may both be radio frequency multipoles. Specifically, the radio frequency multipole ion guide main circuit 001 and the radio frequency multipole ion guide branch 002 can be selected from any one of radio frequency quadrupole, radio frequency hexapole, radio frequency octopole and radio frequency decapole, and the specific structure is not limited . Generally speaking, the structure types of the RF multipole ion guide main circuit 001 and the RF multipole ion guide branch 002 are the same, and they may both be RF quadrupoles, or both RF hexapoles, or both RF octopoles, or both For the radio frequency decapole.

In some embodiments, the radio frequency multipole ion guide main circuit 001 and the radio frequency multipole ion guide branch 002 are both radio frequency quadrupoles, and the radio frequency multipole ion guide main circuit 001 and the radio frequency multipole ion guide branch 002 both include two oppositely arranged two first strip electrodes (that is, the upper and lower strip electrodes of the radio frequency multipole ion guide main circuit 001 in FIG. 1 and the upper and lower strip electrodes of the radio frequency multipole ion guide branch 002 ) and two oppositely arranged second strip electrodes The strip electrodes (that is, the left and right strip electrodes of the radio frequency multipole ion guide main circuit 001 in FIG. 1 and the left and right strip electrodes of the radio frequency multipole ion guide branch 002) are used to utilize the two first strip electrodes and The two second strip electrodes form a linear radio frequency quadrupole ion guiding structure. Both of the two first strip electrodes are divided into a plurality of block electrodes, and the plurality of block electrodes on one first strip electrode are arranged opposite to the plurality of block electrodes on the other first strip electrode, The radial outlet 004 is located on the bulk electrode. As shown in FIG. 1 , the upper and lower strip electrodes of the RF multipole ion guide main circuit 001 and the RF multipole ion guide branch 002 are separated into a plurality of block electrodes, and the number of the upper and lower block electrodes is the same.

Specifically, the block electrodes are two block electrodes 201 disposed oppositely in FIG. 1 , two block electrodes 202 disposed oppositely, two block electrodes 203 disposed oppositely, and two block electrodes 204 disposed oppositely , two block electrodes 205 set oppositely, two block electrodes 206 set oppositely, two block electrodes 207 set oppositely, two block electrodes 208 set oppositely, and two block electrodes 209 set oppositely , Two block electrodes 210 arranged opposite to each other.

Specifically, the connection between the radio frequency multipole ion guide main circuit 001 and the radio frequency multipole ion guide branch 002 is located on a second strip electrode of the radio frequency multipole ion guide main circuit 001, and may be on the second strip electrode The installation port is provided, and the above-mentioned structure can also be formed by using the straight electrode plate 101 , the L-shaped electrode plate 102 and the L-shaped electrode plate 103 . A second strip electrode also serves as a part of the second strip electrode of the radio frequency multipole ion guiding main circuit 001 .

It should be added that the structure of the ion transport device provided by the embodiment of the present invention is not limited to the structure in the drawings. For example, the shape of the electrode is not limited to a rectangle, but can also be a hyperboloid, a circular surface, a plane, etc.; the electrode arrangement is not limited to a straight line, but can also be a cone, a curve, etc.; the branch form is not limited to the above, and can be set more flexibly , the location and shape can be more flexible. The position and number of the ion inlet and ion outlet are not limited to the above, and can be set more flexibly; the segment form is not limited to the above segment, but also all segments, that is, the first strip electrode and the second strip electrode. The electrodes are all segmented, as shown in Figure 6.

The embodiment of the present invention provides an ion transmission method, which uses the above-mentioned ion transmission device for ion transmission, and the ion inlet includes: each axial port, specifically including two axial ports 003 on the radio frequency multipole ion guide main circuit 001 and a radio frequency 1 axial port 003 on the multipole ion guide branch 002 (there may be no axial port on the radio frequency multipole ion guide branch 002); the ion outlet includes: an axial port and a radial outlet, specifically including: radio frequency multipole ion Two axial ports 003 on guide main 001, axial port 003 on RF multipole ion guide branch 002 (may not have axial ports on RF multipole ion guide branch 002), and RF multipole ion guide main 001 and radial outlet 004 on the radio frequency multipole ion guide branch 002. In the working process, a multipole field is radially formed inside the ion transmission device to realize radial confinement of ions; an axial potential well is formed axially inside the ion transmission device to realize the position control of ions.

Specifically, a vacuum system is used to maintain the internal air pressure of the ion transmission device, and the second strip electrodes of the main RF multipole ion guide circuit 001 and the RF multipole ion guide branch 002 (that is, the straight electrode plate 101 in FIG. The same sinusoidal radio frequency voltage is applied to the electrode plate 102 and the L-shaped electrode plate 103) to realize the radial confinement of the ions; pulse or direct current is applied to the opposite two block electrodes 201-210 to An axial potential well is formed inside the device.

The ion transmission device provided by the embodiment of the present invention adopts the following methods to realize the introduction, extraction, collection, movement, dispersion and mixing of ions:

(1) Introduction

Under the action of the electric field, the flow field or the original kinetic energy, the ions are introduced into the ion transport device from the ion inlet by the upstream device, such as from an axial port 003 .

(2) Lead out

The extraction methods of ions include axial extraction and radial extraction.

When the axial extraction method is adopted, the ions are first controlled to stay close to the ion outlet (ie, an axial port 003), and the potential is adjusted to form a potential gradient (the gradient descends or rises depending on the ion species, and the cation has a lower potential The anions move to a higher potential), and the ions are led out from the ion outlet to the downstream device under the guidance of the electric field. For example, when pulling out from the axial port 003 corresponding to the two block electrodes 210 facing up and down, taking cations as an example, the ions are first made to stay between the upper and lower block electrodes 210, and then the upper and lower block electrodes 209, The potential between the electrode 210 and the downstream device becomes a gradient drop, and the ions are led out from the upper and lower bulk electrodes 210 to the downstream device under the guidance of the electric field.

When the radial extraction method is adopted, the ions are first controlled to stay at the position with the radial extraction port 004, the cations move to the lower potential, and the anions move to the higher potential. The outlet 004 is led out to a downstream device. Taking cations as an example, the ions stay at the upper and lower bulk electrodes 209 first, and the potential of one or both of the upper and lower bulk electrodes 209 changes, so that the potential of the upper bulk electrode 209 is lower than that of the lower bulk electrode 209 electric potential; then, under the guidance of the electric field, the ions are extracted from the ion extraction port of the upper bulk electrode 209 to the downstream device.

(3) Collection

The gas is introduced into the ion transmission device, and the kinetic energy is lost by the collision between the ions and the gas, so that the ions are confined in the axial potential well. Cooling to achieve ion collection (ion accumulation at a local location), which can be achieved at different locations of the device.

(4) Mobile

By changing the position of the axial potential well, since the ions will stay at the axial potential well, by changing the voltage of the upper and lower bulk electrodes 201 to 210, the position of the axial potential well is changed to realize the movement of ions. This process This can be done in different locations of the device.

(5) Dispersion

The dispersion of ions is realized by the following method: the ions are gathered at the first position through the axial potential trap, and the electric potential of the axial confinement near the first position is adjusted to be close to the first position, so that the ions are dispersed to the first position due to Coulomb repulsion. nearby, and then changing the potential at the first position (raising or lowering depending on the ion species) to further separate the dispersed ions, which can be achieved at different positions of the device.

As shown in FIG. 1 , taking cations as an example, the ions can first stay at the upper and lower bulk electrodes 204 , and then make the The potentials are the same; then, the ions are dispersed to the upper and lower bulk electrodes 203, 205, and 208 respectively due to Coulomb repulsion; finally, the potential of the upper and lower bulk electrodes 204 is raised to completely separate the dispersed ions.

(6) Mixed

The following method is used to realize the mixing of ions: set the position to be gathered as the second position, first disperse the ions near the second position, and then change the potential of the axial confinement near the second position (the increase or decrease depends on the ion species) ), the ions are gathered at the second position under the action of the electric potential, and the mixing between the ions is realized, and this process can be realized in different positions of the device.

For example, taking cations as an example, ions are dispersed and stayed at the upper and lower bulk electrodes 203, 205, and 208; then, the upper and lower bulk electrodes 203, 205, and 208 are The potential of 208 increases, while the potential of the upper and lower bulk electrodes 204 decreases; finally, under the action of the electric field, the ions gather at the upper and lower bulk electrodes 204 to realize the mixing between the ions.

Further, using the ion transport device to simultaneously couple two or more upstream devices and two or more downstream devices, or one upstream device and two or more downstream devices, or two or more The above upstream device and one downstream device, and the operation modes of the upstream device and the downstream device include: alternate operation in time intervals, real-time alternate operation, and mixed operation.

Specifically, take the coupling of two upstream devices A and B and two downstream devices C and D as an example:

Alternate operation in different time periods means that the operation process is: A.A...B.B..., C.C...D.D..., that is, firstly use the upstream device A to run n times, then use the upstream device B to run n times, and use the downstream device C to run n times first The downstream device D is then run n times.

Real-time alternating operation means that the operation process is: A.B.A.B..., C.D.C.D..., that is, a repeating unit is first inputted by the upstream device A and then inputted once by the upstream device B, and a repeating unit is firstly output by the downstream device C and then use the downstream device. Device D outputs once.

Mixed operation means that the operation process is: AB.AB..., CD.CD..., that is, the upstream device A and the upstream device B input at the same time, and the downstream device C and the downstream device D receive at the same time.

Among them, the "." in the operation process represents a complete ion transmission process; during alternate operation, the utilization of ions can be improved through ion collection, ion confinement, etc.; ionic group.

What needs to be added is that the air pressure is adjustable during the ion drive process, which is not limited; the form of radio frequency can be sine wave radio frequency or square wave radio frequency; the number of radio frequency is not limited to a simple 1 channel, but can also be a conventional 2 channel; Pulse: Not limited to bi-level pulses, but multi-level pulses, even AC for other functions.

To sum up, the embodiments of the present invention provide an ion transmission device and an ion transmission method. Based on the radio frequency multipole ion guidance, the radio frequency multipole ion guide branch is arranged on the main path of the radio frequency multipole ion guidance, so that the radio frequency multipole ion guide can be The guide branch is used as the axial branch of the radio frequency multipole ion guide main circuit. A flexible potential well is formed in the axial direction; ions can be introduced through the axial ports on the RF multipole ion guide main circuit and the RF multipole ion guide branch, and the ions can be introduced through the RF multipole ion guide main circuit and the RF multipole ion guide branch Axial ports and radial extraction ports on the ion are extracted. Has the following advantages:

(1) The flexible connection of more upstream devices (such as ion sources) and more downstream devices (such as mass analyzers) is realized;

(2) For a single upstream device, the functions of the introduction of the extracted ions, centralized and batch collection, centralized and batch confinement, dispersion, cooling focusing, flexible movement, and axial or radial extraction of various positions are realized;

(3) For multiple upstream devices, the functions such as mixing and flexible alternate extraction of the extracted ions are realized;

(4) For a single downstream device, functions such as the extraction of the introduced ions and the axial introduction of various positions are realized.

The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present invention should be Included within the scope of protection of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.

Claims (9)

1. An ion transmission device, characterized in that it comprises a radio frequency multipole ion guide main circuit and a radio frequency multipole ion guide branch, and the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are both linear. The radio frequency multipole ion guide, the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch have two oppositely arranged axial ports, and one or both of the radio frequency multipole ion guide branch The axial port is communicated with the radio frequency multipole ion guide main circuit to serve as an axial branch of the radio frequency multipole ion guide main circuit; The axial direction of the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch is divided into multiple sections, so as to form an axial potential well by applying different and variable voltages to each section; A radial lead-out port is provided on the radio frequency multipole ion guide main circuit and/or the radio frequency multipole ion guide branch. 2 . The ion transmission device according to claim 1 , wherein the radio frequency multipole ion guiding branch is a plurality of, and the plurality of the radio frequency multipole ion guiding branches and the main circuit of the radio frequency multipole ion guiding are connected. 3 . The communication points are located in the same section or in different sections of the radio frequency multipole ion guiding main path, and the extension directions of the plurality of the radio frequency multipole ion guiding branches are the same or different. 3 . The ion transmission device according to claim 1 , wherein the radio frequency multipole ion guide branch is further connected with a secondary radio frequency multipole ion guide branch. The polar ion guide branch has two oppositely arranged axial ports, and one or both of the axial ports of the secondary radio frequency multipole ion guide branch communicate with the radio frequency multipole ion guide branch to serve as the radio frequency Axial branch of the multipole ion guide branch; A tertiary radio frequency multipole ion guiding branch is also connected to the secondary radio frequency multipole ion guiding branch, so that the tertiary radio frequency multipole ion guiding branch serves as the axial branch of the secondary radio frequency multipole ion guiding ; The three-stage radio frequency multipole ion guide branch is also connected with a fourth-stage radio frequency multipole ion guide branch, and so on to form a multi-stage branch structure, each level of branch serving as an axial branch of the previous level branch. 4 . The ion transmission device according to claim 1 , wherein the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are both radio frequency multipoles. 5 . 5 . The ion transmission device according to claim 4 , wherein the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guide branch are both radio frequency quadrupoles, and the radio frequency multipole ion guide main circuit and the radio frequency multipole ion guiding branches each include two first strip electrodes disposed oppositely and two second strip electrodes disposed opposite to each other, so as to utilize the two first strip electrodes and the two second strip electrodes. The two strip electrodes form a linear radio frequency quadrupole ion guiding structure; Both of the two first strip electrodes are divided into a plurality of block electrodes, and a plurality of block electrodes on one of the first strip electrodes and a plurality of block electrodes on the other of the first strip electrodes are formed. The block electrodes are arranged opposite to each other, and the radial outlet is located on the block electrodes. 6. An ion transmission method, characterized in that it uses the ion transmission device according to any one of claims 1-5 to carry out ion transmission, and the ion inlet comprises: an axial port; The ion outlet includes: axial port and radial outlet; A multipole field is radially formed inside the ion transmission device to achieve radial confinement of ions; an axial potential well is formed axially inside the ion transmission device to achieve position control of ions. 7 . The ion transmission method according to claim 6 , wherein ions are introduced into the ion transmission device from the ion inlet by an upstream device, and are extracted by means of axial extraction or radial extraction; 7 . Wherein, when the axial extraction method is adopted, the ions are first controlled to stay at a position close to the ion outlet, and the ions are extracted from the ion outlet to the downstream device under the guidance of the electric field by adjusting the electric potential; When the radial extraction method is adopted, the ions are first controlled to stay at the position with the radial extraction opening, and the ions are extracted from the radial extraction opening to the downstream device under the guidance of the electric field by regulating the electric potential; Preferably, gas is introduced into the ion transmission device, and the kinetic energy is lost due to collision between ions and gas, so that the ions are confined in the axial potential well; the ions are gradually focused under continuous collision cooling, and the ions are continuously implanted, confined and cooled to achieve Collection of ions. 8. The ion transmission method according to claim 6, wherein the ion movement is realized by changing the position of the axial potential well; Preferably, the dispersion of ions is realized by the following method: the ions are gathered at the first position through the axial potential trap, and the electric potential of the axial confinement near the first position is adjusted to be close to the first position, so that the ions are separated due to Coulomb repulsion. Disperse to the vicinity of the first position, and then change the potential of the first position to further separate the dispersed ions; Preferably, the following method is used to realize the mixing of ions: set the position to be gathered as the second position, first disperse the ions near the second position, and then change the potential of the axial confinement near the second position to make the ions Aggregation at the second location under the action of an electrical potential achieves inter-ionic mixing. 9 . The ion transmission method according to claim 6 , wherein the ion transmission device is used to simultaneously couple two or more upstream devices and two or more downstream devices, or one upstream device and Two or more downstream devices, or two or more upstream devices and one downstream device, and the operation modes of the upstream device and the downstream device include: alternate operation in time periods, alternate operation in real time, and Mixed operation.

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