CN115341002A - Preparation method of zinc gluconate solution - Google Patents

Abstract

The invention provides a method for preparing a zinc gluconate solution, and relates to the technical field of zinc gluconate preparation. It includes the step of preparing the first liquid material, mixing the first mixed raw materials and then performing the first treatment process through the zinc gluconate production equipment to obtain the first liquid material. In the step of preparing the second liquid material, the first liquid material is mixed with the second mixed raw material in the zinc gluconate production equipment, and then the second treatment process is performed to obtain the second liquid material. In the step of obtaining zinc gluconate, after the sample of the second liquid material is taken out in the zinc gluconate production equipment to reach the target glucose content, the zinc gluconate solution is obtained in the zinc gluconate production equipment through the third treatment process and discharged. In the process of preparing zinc gluconate by adopting the method, the material output in the reaction section has high concentration and low water content, and the amount of water to be evaporated in the subsequent evaporation section is reduced. Avoid damage to enzyme activity caused by local high temperature and high-speed stirring and improve enzyme survival.

Description

A kind of preparation method of zinc gluconate solution

technical field

The invention relates to the technical field of zinc gluconate preparation, in particular to a preparation method of zinc gluconate solution.

Background technique

Zinc is an essential trace element for the human body. As a prosthetic group of various enzymes, zinc acts on the structure, regulation and activation of enzymes. Zinc gluconate, as a preferred zinc supplement, has the advantages of easy absorption, high bioavailability, small side effects, and convenient use. It is a commonly used zinc supplement drug or nutritional enhancer. In addition, zinc gluconate can also be added to cosmetic products to treat acne, and added to feed as a nutritional enhancer.

The production methods of zinc gluconate mainly include common chemical method, catalytic oxidation method, electrolytic oxidation method, fermentation method, double enzyme method and so on. The main principle of the enzyme-catalyzed production of zinc gluconate is to use glucose oxidase and catalase to oxidize glucose into gluconic acid, and the reaction of gluconic acid and zinc oxide produces zinc gluconate. Zinc gluconate produced by enzyme catalysis is completed in a stirred reactor with a jacket. The air in the reactor provides the oxygen required for the oxidation process, and the stirring action of the stirring paddle completes the glucose, zinc oxide, water, glucose oxidase, and oxygen Catalase, air and other raw materials are mixed, and steam and cooling water are respectively passed into the jacket of the reaction kettle to complete the heating and cooling of the reaction process.

The technology of zinc gluconate produced by the existing enzyme-catalyzed method has the following problems: 1, the initial reaction material glucose concentration is no more than 34% (W/V), and the amount of water that needs to be evaporated in the follow-up evaporation section is large. 2. The suitable reaction temperature of the enzyme is about 35°C, and the enzyme will be completely killed if it exceeds 80°C. However, the existing technology of enzyme-catalyzed oxidation to produce zinc gluconate adopts the method of steam heating, stirring and mixing heat transfer, because the steam temperature is higher than 100°C , There is a local high-temperature zone in the reactor that leads to the inactivation and failure of some enzymes, and the high-speed stirring of the stirring paddle will damage the activity of the enzyme, resulting in the weakening of the activity of the enzyme in some links of the reaction process and reducing the production efficiency.

For this reason, also need to further solve for above-mentioned technical problem.

Contents of the invention

The purpose of the embodiment of the present invention is to provide a preparation method of zinc gluconate solution, in the process of preparing zinc gluconate, the concentration of the material produced in the reaction section is high and the water content is low, and the amount of water to be evaporated in the subsequent evaporation section is reduced. Avoid damage to enzyme activity caused by local high temperature and high-speed stirring, improve enzyme survival, and reduce enzyme loss.

In order to solve the above technical problems, embodiments of the present invention provide the following technical solutions:

The first aspect of the present invention provides a kind of preparation method of zinc gluconate solution, comprising:

In the step of preparing the first liquid material, the first mixed raw material is mixed and then the first treatment process is carried out through the zinc gluconate production equipment to obtain the first liquid material;

The step of preparing the second liquid material is to carry out the second treatment process after mixing the first liquid material and the second mixed raw material in the zinc gluconate production equipment to obtain the second liquid material;

Obtaining the zinc gluconate step, after taking out the sample of the second liquid material in the zinc gluconate production equipment to reach the target glucose content, the zinc gluconate solution is obtained in the zinc gluconate production equipment through the third treatment process and for discharging;

The zinc gluconate production equipment includes a cylinder, the cylinder is respectively provided with a feed inlet and a discharge port, the cylinder is provided with a guide tube, and the guide tube passes between the guide tube and the cylinder Supported by the first support unit, the cylinder body and the guide cylinder are inserted by a part of the push unit at the same time, the cylinder body and part of the first support unit are connected to the cooling unit at the same time, and part of the cooling unit Located between the cylinder and the guide cylinder, the outside of the cylinder and the inside of the cylinder are provided with an electromagnetic induction heating unit, the cylinder is connected to an aeration unit, and the outside of the cylinder Covered with insulation layer;

Wherein, the heating method in the third treatment process is to heat through the electromagnetic induction heating unit and the aeration unit, and when the heating reaches the target temperature, the aeration unit is turned off, and the electromagnetic induction heating unit is continued to be turned on, The temperature of the liquid in the barrel was maintained at 61°C to 67°C for 60min to 70min.

Further, the composition ratio of the first mixed raw material is: water, glucose dry matter, zinc oxide;

Wherein, the glucose solution is obtained after the glucose dry material and the water are mixed, the concentration of the glucose solution is 35%-50% (W/V), and the addition amount of zinc oxide is 20%-20% of the glucose dry material. 25% (W/W);

The composition ratio of the second mixed raw material is: glucose oxidase, catalase;

Wherein, the addition amount of glucose oxidase is 0.25%-0.5% (W/W) of glucose dry material, and the addition amount of catalase is 0.15%-0.25% (W/W) of glucose dry material.

Further, the first support unit includes:

First support rods, one end of each first support rod is connected to the guide tube, and the other end of each first support rod is connected to the inner wall of the cylinder;

As for the second support rods, one end of each second support rod is connected with the first support rod, and the other end of each second support rod is connected with the cooling unit.

Further, the push unit includes:

A push motor is arranged on the outside of the barrel;

a reducer, arranged outside the barrel and connected to the push motor;

A transmission shaft, one end of the transmission shaft is connected to the reducer, and the other end of the transmission shaft is inserted into the cylinder and the guide cylinder at the same time;

The propeller is connected to the end of the transmission shaft away from the speed reducer, and rotates in the guide tube.

Further, the cooling unit includes:

a plate piece, the end of the plate piece is connected to the second support rod;

The first cooling water pipe is arranged between the adjacent plate parts and distributed circumferentially with the guide tube as the center;

The first water inlet pipe, one end of the first water inlet pipe communicates with the end of the first cooling water pipe away from the ground side, and the other end of the first water inlet pipe passes through the cylinder to connect with the external water pipe ;

The first water outlet pipe, one end of the first water outlet pipe communicates with the end of the first cooling water pipe near the ground side, and the other end of the first water outlet pipe passes through the cylinder to connect with the external water pipe ;

in,

A flow controller is provided on the first water inlet pipe close to the inlet of the first water inlet pipe, and a first valve is arranged on the first water inlet pipe between the insulation layer and the flow controller;

A second valve is arranged on the first water outlet pipe outside the cylinder.

Further, the electromagnetic induction heating unit includes:

The electromagnetic induction coil is arranged on the outer surface of the thermal insulation layer near the guide tube;

The first temperature sensor is arranged on the surface of the cylinder close to the side of the insulation layer;

The second temperature sensor is arranged on any one of the first support rods;

A controller controls the electromagnetic induction coil and receives temperature data obtained by the first temperature sensor and the second temperature sensor respectively.

Further, the aeration unit includes:

A first air intake pipe, one end of the first air intake pipe is arranged in the cylinder, and the other end of the first air intake pipe passes out of the cylinder to communicate with the outside air;

The aeration heads are evenly arranged on the first air inlet pipe in the cylinder, and the outlet of each aeration head faces the side of the guide cylinder;

a gas heating device arranged on the first air intake pipe near the entrance of the first air intake pipe;

The third valve is arranged on the first air intake pipe between the gas heating device and the insulation layer;

Wherein, a plurality of said aeration heads are uniformly distributed in the lower part of the cylinder body and distributed in a circle.

Further, the first processing procedure includes:

In the step of pushing and rotating, after adding the first mixed raw material into the barrel, start the electromagnetic induction heating unit for heating, and start the pushing motor and the reducer at the same time to make the drive shaft drive the propeller to rotate, the The first mixed raw material forms a circulating flow path between the inside of the draft tube and the outside of the draft tube;

In the first aeration step, the temperature of the air flowing out of the gas heating device is set to 27°C to 32°C and the third valve is opened, the ventilation rate is 0.5vvm, and the aeration unit performs aeration;

In the first temperature control step, when the temperature of the first mixed raw material is 30°C to 35°C, the electromagnetic induction heating unit is turned off, the propeller continues to rotate for 30min to 35min and the aeration unit continues to aerate for 30min to 35min. 35min;

Wherein, before the pushing and rotating step, the first water inlet pipe and the first water outlet pipe are in a closed state.

Further, the second processing procedure includes:

In the second aeration step, the second mixed raw material is added into the cylinder, the propeller continues to rotate, the aeration unit and the third valve continue to open, the gas heating device is closed, and air at normal temperature enters Aeration is carried out in the first air intake pipe and through the aeration unit;

In the cooling step, the first valve and the second valve are opened, and the external cooling water enters the first cooling water pipe through the first water inlet pipe and then flows out of the cylinder body through the first water outlet pipe;

In the second temperature control step, the flow controller dynamically adjusts the flow rate of the cooling water according to the temperature value detected by the second temperature sensor, so that the temperature of the liquid in the cylinder is maintained at 34°C to 41°C;

Wherein, in the second aeration step, the pressure of the air at normal temperature is 0.15MPa, and the ventilation volume is 1.0vvm.

Further, the third processing procedure includes:

Stop the heating step, when the glucose content of the sample taken out is below 0.5%, close the first valve and the second valve, the propeller continues to rotate, the aeration unit and the third valve continue to open, ventilate The amount is 0.5vvm, and the electromagnetic induction heating unit and the gas heating device are turned on at the same time. When the temperature of the liquid material in the cylinder reaches 60°C or above, the gas heating device, aeration unit and the third valve are turned off. , adding unqualified zinc gluconate solid material, the propeller continues to rotate, the electromagnetic induction heating unit continues to be turned on, and the temperature of the liquid in the cylinder is maintained at 60°C to 65°C for 60min to 70min;

Stop promoting step, close described promoting motor and described electromagnetic induction heating unit, and obtain zinc gluconate solution after described propeller stops rotating.

Compared with the prior art, in the preparation method of the zinc gluconate solution provided by the first aspect of the present invention, the first mixed raw materials are mixed in the zinc gluconate production equipment and the first liquid material is obtained after the first treatment process. Secondly, in the zinc gluconate production equipment, the first liquid material is mixed with the second mixed raw material and the second treatment process is performed to obtain the second liquid material. Finally, after the sample taken out of the zinc gluconate production equipment reaches the target glucose content, a zinc gluconate solution is obtained after the third treatment process is performed in the zinc gluconate production equipment. During the reaction process, the heating method is to heat the liquid material through the electromagnetic induction heating unit and the aeration unit. The heating temperature is precisely controllable, the heat conduction process is short, and the heating is uniform and rapid, which avoids local high temperature phenomenon and reduces the impact on the second liquid. The effect of enzyme activity in the material. In the third treatment process, close the aeration unit when it is heated to the target temperature, add unqualified zinc gluconate solid material, and maintain the liquid temperature in the cylinder at 60°C to 65°C for 60min to 70min, which can increase the glucose concentration. The quality and uniformity of the acid zinc solution are beneficial to the production and processing of the subsequent filtration section and evaporation section.

In the zinc gluconate production equipment, the first support unit fixes the diversion cylinder, and the push unit makes the first mixed raw material or the mixture of the first liquid material and the second mixed raw material flow inside and outside the diversion cylinder. The circulating flow forms a circulating flow path. The cooling unit cools down the circulating liquid flow, the electromagnetic induction heating unit heats up the circulating liquid flow, and the aeration unit aerates and oxygenates the circulating flow path. Thus, the oxygenation efficiency of the first liquid material and the second liquid material is improved, and the concentration of the glucose dry material can be greater than 34% at the beginning of the reaction. The material produced in the reaction section has a high concentration and low water content, and the amount of water that needs to be evaporated in the subsequent evaporation section reduce. The low-speed rotation of the push unit controls the directional circulation of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material, combined with the aeration unit to make the material mix more evenly, and avoid the damage to the enzyme activity caused by high-speed stirring. The heating temperature of the electromagnetic induction heating unit can be precisely controlled, and there is no high temperature phenomenon that affects the enzyme activity, which improves the survival of the enzyme and reduces the loss of the enzyme.

Description of drawings

The above and other objects, features and advantages of exemplary embodiments of the present invention will become readily understood by reading the following detailed description with reference to the accompanying drawings. In the accompanying drawings, several embodiments of the present invention are shown in an exemplary rather than restrictive manner, and the same or corresponding reference numerals represent the same or corresponding parts, wherein:

Fig. 1 schematically shows the flow chart of the preparation method of zinc gluconate solution;

Fig. 2 schematically shows the schematic diagram of zinc gluconate production equipment;

Fig. 3 schematically shows a schematic view of the first supporting unit;

Fig. 4 schematically shows a schematic diagram of a pushing unit;

Figure 5 schematically shows a schematic diagram of the cooling unit;

Fig. 6 schematically shows a schematic diagram of an electromagnetic induction heating unit;

Figure 7 schematically shows a schematic diagram of an aeration unit;

Fig. 8 schematically shows a schematic diagram of a draft tube;

Fig. 9 schematically shows a schematic view of the flow direction of the liquid material;

Explanation of reference numbers:

1. Cylinder body; 11. Inlet port; 12. Outlet port;

2. Insulation layer;

3. Electromagnetic induction heating unit; 31. Electromagnetic induction coil; 32. Controller; 33. First temperature sensor; 34. Second temperature sensor;

4. Guide tube; 41. First opening; 42. Second opening; 43. Tube wall;

5. Aeration unit; 51. The first air intake pipe; 52. Gas heating device; 53. Aeration head; 54. The third valve;

6. Cooling unit; 61. First water inlet pipe; 62. Flow controller; 63. First valve; 64. First cooling water pipe; 65. Second valve; 66. First water outlet pipe; 67. Plate parts;

7. The first support unit; 71. The first support rod; 72. The second support rod;

8. Propelling unit; 81. Propelling motor; 82. Reducer; 83. Transmission shaft; 84. Propeller.

Detailed ways

Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided for more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art. Unless otherwise specified, the technical means used in the embodiments are conventional means well known to those skilled in the art.

It should be noted that, unless otherwise specified, the technical terms or scientific terms used in the present invention shall have the usual meanings understood by those skilled in the art to which the present invention belongs. In this document, relational terms such as "first" and "second", etc., are only used to distinguish one entity or operation from another, and do not necessarily require or imply that there is a relationship between these entities or operations. There is no such actual relationship or sequence. Terms such as "connection" and "connection" should be understood in a broad sense, for example, it can be fixed connection, detachable connection, or integrated; it can be mechanical connection or electrical connection; it can be direct connection or It can be connected indirectly through an intermediary. The term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or apparatus comprising a set of elements includes not only those elements but also other elements not expressly listed elements, or also elements inherent in such a process, method, article, or apparatus. Without further limitations, an element defined by the statement "comprising..." does not exclude the presence of additional same elements in the process, method, article or device comprising said element.

As shown in Figure 1, the embodiment of the present invention provides a kind of preparation method of zinc gluconate solution, comprising:

In the step of preparing the first liquid material, the first mixed raw material is mixed and then the first treatment process is carried out through the zinc gluconate production equipment to obtain the first liquid material.

In the step of preparing the second liquid material, the first liquid material is mixed with the second mixed raw material in the zinc gluconate production equipment, and then the second treatment process is performed to obtain the second liquid material.

In the step of obtaining zinc gluconate, after the sample of the second liquid material is taken out in the zinc gluconate production equipment to reach the target glucose content, the zinc gluconate solution is obtained in the zinc gluconate production equipment through the third treatment process and discharged.

As shown in Figure 2, the zinc gluconate production equipment comprises cylinder body 1, and cylinder body 1 is provided with feed inlet 11 and discharge port 12 respectively, also comprises guide tube 4, first support unit 7, push unit 8, Cooling unit 6 , electromagnetic induction heating unit 3 , aeration unit 5 and insulation layer 2 . A guide tube 4 is arranged inside the cylinder 1, and the first support unit 7 is used to support the guide tube 4 and the cylinder 1. The cylinder 1 and the guide tube 4 are inserted by a part of the push unit 8 at the same time, and the cylinder 1 And part of the first support unit 7 is connected to the cooling unit 6 at the same time, and part of the cooling unit 6 is located between the cylinder 1 and the guide cylinder 4, and the outside of the cylinder 1 and the inside of the cylinder 1 are provided with an electromagnetic induction heating unit 3 , The cylinder body 1 is connected with an aeration unit 5 , and the outside of the cylinder body 1 is covered with an insulation layer 2 .

Among them, the heating method in the third treatment process is to heat through the electromagnetic induction heating unit and the aeration unit, and turn off the aeration unit when heating to the target temperature, continue to turn on the electromagnetic induction heating unit, and then maintain the temperature of the liquid in the cylinder. At 61°C to 67°C, while maintaining for 60min to 70min.

Specifically, firstly, in the zinc gluconate production equipment, the first mixed raw material is mixed and subjected to the first treatment process to obtain the first liquid material. Secondly, in the zinc gluconate production equipment, the first liquid material is mixed with the second mixed raw material and the second treatment process is performed to obtain the second liquid material. Finally, after the sample taken out of the zinc gluconate production equipment reaches the target glucose content, a zinc gluconate solution is obtained after the third treatment process is performed in the zinc gluconate production equipment. During the reaction process, the heating method is heating through the electromagnetic induction heating unit and the aeration unit, and heating is carried out inside the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material. The heating temperature is precise and controllable, and the heat conduction process Short, uniform and rapid heating, avoiding local high temperature phenomena, and reducing the impact on the activity of enzymes in the second liquid material. Turn off the aeration unit when heating to the target temperature, and then maintain the liquid temperature in the cylinder at 60°C to 65°C for 60min to 70min, which is conducive to stabilizing the activity of zinc gluconate and improving the survival of the enzyme.

In the zinc gluconate production equipment, the first support unit 7 fixes the guide cylinder 4, and the push unit 8 makes the mixed liquid of the first mixed raw material or the first liquid material and the second mixed raw material flow in the guide cylinder 4 and guide Circulating flow is carried out outside the flow tube 4 to form a circulating flow path, as shown in FIG. 9 . The cooling unit 6 cools the circulating liquid flow, the electromagnetic induction heating unit 3 heats up the first mixed raw material flowing along the circulating flow path or the mixed liquid of the first liquid material and the second mixed raw material, and the aeration unit 5 cools the circulating liquid flow. Perform aeration and oxygenation. Thus, the oxygenation efficiency of the first liquid material and the second liquid material is improved, and the concentration of the glucose dry material can be greater than 34% at the beginning of the reaction. The material produced in the reaction section has a high concentration and low water content, and the amount of water that needs to be evaporated in the subsequent evaporation section reduce. The push unit 8 rotates at a low speed to control the directional circulation of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material, combined with the aeration unit 5 to make the material mix more uniformly, and avoid damage to the enzyme activity caused by high-speed stirring. The heating temperature of the electromagnetic induction heating unit 3 can be precisely controlled, and there is no high temperature phenomenon affecting the activity of the enzyme, which improves the survival of the enzyme and reduces the loss of the enzyme.

In order to prevent the heat loss of the liquid material in the cylinder 1 and reduce the heat in the cylinder 1 to the side of the electromagnetic induction heating unit 3 , the cylinder 1 is covered with an insulation layer 2 .

In a specific embodiment, the composition ratio of the first mixed raw material is: water, glucose dry material, and zinc oxide. Wherein, the glucose solution is obtained after the glucose dry material and water are mixed, the concentration of the glucose solution is 35%-50% (W/V), and the addition of zinc oxide is 20%-25% (W/W) of the glucose dry material ). The composition ratio of the second mixed raw material is: glucose oxidase, catalase. Wherein, the addition amount of glucose oxidase is 0.25%-0.5% (W/W) of glucose dry material, and the addition amount of catalase is 0.15%-0.25% (W/W) of glucose dry material.

In some modified implementations of the first aspect of the present invention, with reference to FIG. 2 and FIG. 3 , the first support unit 7 includes a first support rod 71 and a second support rod 72 . First support rods 71 , one end of each first support rod 71 is connected to the guide tube 4 , and the other end of each first support rod 71 is connected to the inner wall of the cylinder body 1 . The second support rods 72 , one end of each second support rod 72 is connected with the first support rod 71 , and the other end of each second support rod 72 is connected with the cooling unit 6 .

Specifically, the first support rod 71 connects the guide tube 4 and the inner wall of the cylinder body 1 to support the guide tube 4 . The second support rod 72 connects the first support frame 71 and the cooling unit 6 at the same time, so as to support the cooling unit 6 .

In the present invention, the first support rod 71 and the second support rod 72 are rod-shaped structures, which reduce the resistance to the flow of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material.

In a specific embodiment, referring to FIG. 2 and FIG. 4 , the pushing unit 8 includes a pushing motor 81 , a reducer 82 , a transmission shaft 83 and a propeller 84 . The push motor 81 is arranged outside the cylinder body 1 . The speed reducer 82 is arranged outside the barrel 1 and connected with the push motor 81 . Transmission shaft 83 , one end of transmission shaft 83 is connected with speed reducer 82 , and the other end of transmission shaft 83 is inserted into cylinder body 1 and guide cylinder 4 at the same time. The propeller 84 is connected to the end of the transmission shaft 83 on the side away from the speed reducer 82 , and rotates inside the inducer 4 .

Specifically, the propeller 84 is driven to rotate by the propulsion motor 81 and the reducer 82 through the transmission shaft 83 . Under the action of the speed reducer 82, the rotation speed of the propeller 84 is reduced.

The rotation of the propeller 84 pushes the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material in the guide tube 4 to flow to the ground side, and the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material After flowing out from the guide tube 4, it flows through the space between the cylinder body 1 and the guide tube 4 toward the side away from the ground, and then flows into the guide tube 4 through the top of the guide tube 4. That is to say, the rotation of the propeller 84 pushes the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material to circulate inside and outside the draft tube 4 , as shown in FIG. 9 .

In a specific embodiment, as shown in FIG. 5 , the cooling unit 6 includes a first cooling water pipe 64 , a plate member 67 , a first water inlet pipe 61 and a first water outlet pipe 66 . The end of the plate member 67 is connected to the second support rod 72 . The first cooling water pipes 64 are arranged between adjacent plate parts 67 and distributed circumferentially with the guide tube 4 as the center of the circle. The first water inlet pipe 61, one end of the first water inlet pipe 61 communicates with the end of the first cooling water pipe 64 away from the ground side, and the other end of the first water inlet pipe 61 passes through the cylinder body 1 to connect with the external water pipe. The first water outlet pipe 66, one end of the first water outlet pipe 66 communicates with the end of the first cooling water pipe 64 near the ground side, and the other end of the first water outlet pipe 66 passes through the cylinder body 1 to connect with the external water pipe. Wherein, a flow controller 62 is provided on the first water inlet pipe 61 close to the entrance of the first water inlet pipe 61 , and a first valve 63 is arranged on the first water inlet pipe 61 between the insulation layer 2 and the flow controller 62 . A second valve 65 is provided on the first water outlet pipe 66 outside the cylinder body 1 .

Specifically, each second support rod 72 is arranged in the middle between the barrel 1 and the flow guide tube 4 , so that the first cooling water pipe 64 is also located in the middle between the barrel 1 and the flow guide tube 4 . The first cooling water pipe 64 communicates with the first water inlet pipe 61 and the first water outlet pipe 66 at the same time.

The wall of the first cooling water pipe 64 can generate heat under the action of the electromagnetic induction coil 31 to heat the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material flowing through the first cooling water pipe 64 .

As another situation, due to the continuous flow of cooling water in the first cooling water pipe 64, the temperature of the pipe wall of the first cooling water pipe 64 can be lowered, so as to realize the cooling of the first mixed raw material or the first liquid flowing through the first cooling water pipe 64. The temperature of the mixed solution of the material and the second mixed raw material is lowered.

As the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material circulates under the impetus of the propeller 84, the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material flows through the barrel 1 and the guide tube 4 , the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material will flow through the outer periphery of the first cooling water pipe 64 . After passing the cooling water into the first cooling water pipe 64 , the temperature of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material flowing through the first cooling water pipe 64 is cooled. At the same time, due to the continuous circulation of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material in the guide tube 4 and outside the guide tube 4, all the first mixed raw materials or the first mixed raw material in the cylinder body 1 Both the liquid material and the mixed liquid of the second mixed raw material are cooled by the first cooling water pipe 64 .

Wherein, the first cooling water pipe 64 may be a spiral coil pipe, a U-shaped pipe, or other types of pipe.

Both the first valve 63 and the second valve 65 are opened or closed under the action of the flow controller 62 .

When the first valve 63 is opened, external cooling water enters the first water inlet pipe 61 and then flows into the first cooling water pipe 64 .

When the second valve 65 is opened, the cooling water in the first cooling water pipe 64 flows out through the first water outlet pipe 66 .

In a specific embodiment, referring to FIG. 2 and FIG. 6 , the electromagnetic induction heating unit 3 includes an electromagnetic induction coil 31 , a first temperature sensor 33 and a controller 32 . The electromagnetic induction coil 31 is arranged on the outer surface of the thermal insulation layer 2 near the guide tube 4 . The first temperature sensor 33 is arranged on the surface of the cylinder body 1 near the insulation layer 2 side. The second temperature sensor 34 is disposed on any one of the first support rods 71 . The controller 32 controls the electromagnetic induction coil 31 and receives temperature data obtained by the first temperature sensor 33 and the second temperature sensor 34 respectively.

Specifically, since the electromagnetic induction coil 31 is close to the outer surface of the thermal insulation layer 2 at the guide tube 4 , the distance between the electromagnetic induction coil 31 and the guide tube 4 is reduced.

After the electromagnetic induction coil 31 is fed with a high-frequency induction current, an alternating magnetic field will be generated in the electromagnetic induction coil 31 . Under the action of the alternating magnetic field, the metal conductor in the electromagnetic induction coil 31 will generate an induced current. Due to the skin effect of electromagnetic heating, the induced current will simultaneously generate heat on the outer surfaces of the cylinder body 1 , the guide cylinder 4 and the first cooling water pipe 64 . The first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material directly contacts the inner wall of the cylinder body 1, the inner wall of the guide tube 4, the outer wall of the guide tube 4, and the outer periphery of the first cooling water pipe 64 and The circulating flow makes all the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material in the barrel 1 be heated up. Wherein, the guide cylinder 4, the cylinder body 1 and the first cooling water pipe 64 are all made of magnetically permeable metal materials in the prior art.

Optionally, a plate piece 67 is provided on the outer surface of the first cooling water pipe 64 and the plate piece 67 is parallel to the flow guiding cylinder 4 . The induced current will simultaneously generate heat on the outer surfaces of the cylinder body 1 , the guide cylinder 4 and the plate member 67 . The plate member 67 reduces the resistance to the first mixed raw material or the mixed liquid of the first mixed raw material or the first liquid material and the second mixed raw material during the circulating flow of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material, and at the same time Since the plate piece 67 is evenly heated, a better heating effect can be achieved, and the plate piece 67 is easier to clean. Wherein, the plate member 67 is made of magnetically permeable metal material in the prior art.

As another implementation manner, when cold water flows into the first cooling water pipe 64 , the cold water in the first cooling water pipe 64 can cool down the plate member 67 .

The first temperature sensor 31 is used to measure the real-time temperature of the barrel 1 , and the second temperature sensor 34 is used to measure the real-time temperature of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material in the barrel 1 . Wherein, according to different usage requirements, the second temperature sensor 34 can also be arranged on any second support rod 72 .

The controller 32 controls the electromagnetic induction coil 31 and the first temperature sensor 33 and the second temperature sensor 34 respectively. Wherein, the control method and the control process are all prior art, so the present invention will not describe it in detail.

In a specific embodiment, referring to FIG. 2 and FIG. 7 , the aeration unit 5 includes a first air inlet pipe 51 , an aeration head 53 , a gas heating device 52 and a third valve 54 . The first air inlet pipe 51, one end of the first air inlet pipe 51 is arranged in the cylinder body 1, and the other end of the first air inlet pipe 51 passes through the cylinder body 1 to communicate with the outside air. The aeration heads 53 are evenly arranged on the first air inlet pipe 51 located in the cylinder body 1 , and the outlet of each aeration head 53 is toward the side of the flow guide cylinder 4 . The gas heating device 52 is arranged on the first air intake pipe 51 near the entrance of the first air intake pipe 51 . The third valve 54 is arranged on the first air inlet pipe 51 between the gas heating device 52 and the insulation layer 2 . Wherein, a plurality of said aeration heads are uniformly distributed in the lower part of the cylinder body and distributed in a circle.

Specifically, both the first air intake pipe 51 and the aeration head 53 are located in the cylinder 1 close to the ground side, and the external air with pressure enters the aeration head 53 from the third valve 54, and the aeration head 53 is provided with a plurality of Air is ejected from the micropores to form a plurality of air bubbles that are sprayed into the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material. Due to the continuous circulation of the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material in the cylinder 1, and superimposed buoyancy at the same time, multiple air bubbles will float up from the cylinder 1 near the ground side to the cylinder 1 The first mixed raw material at the top or the mixed liquid of the first liquid material and the second mixed raw material escapes from the surface. During the floating process, the bubbles fully contact with the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material, and the oxygen in the bubble dissolves into the first mixed raw material or the mixture of the first liquid material and the second mixed raw material liquid.

Before the aeration head 53 is not aerated, the micropores are under the action of liquid pressure and are in a closed state. When the aeration head 53 performs aeration, air is ejected from the micropores. Wherein, the structure and material of the micropores adopt the prior art.

The more micropores on the aeration head 53, the more bubbles are formed, the larger the contact area between the gas and the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material, and the gas will dissolve into the first mixed raw material. The more oxygen there is in the raw material or the mixed liquid of the first liquid material and the second mixed raw material.

Before the external air enters the aeration head 53, it is heated to the target temperature by the gas heating device 52, and the target temperature is determined according to different materials, so the present invention will not describe it in detail.

According to different usage requirements, the gas heating device 52 can be heated by an electromagnetic induction device, or a device or device in the prior art that can heat air.

In a specific embodiment, as shown in FIG. 8 , the guide cylinder 4 includes a cylinder wall 43 , a first opening 41 and a second opening 42 . The first opening 41 is provided at the end of the cylinder wall 43 away from the ground. The second opening 42 is provided at the end of the cylindrical wall 43 near the ground.

Specifically, the liquid material in the guide tube 4 flows out from the second opening 42 , and then enters into the guide tube 4 from the first opening 41 , forming a circulating flow in the cylinder body 1 .

In the present invention, the guide tube 4 is located in the center of the cylinder body 2, on the one hand, it is beneficial for the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material to circulate in the cylinder body 2, and on the other hand Make the first cooling water pipe 64 cool down the first mixed raw material or the mixed liquid of the first liquid material and the second mixed raw material more uniformly.

In a specific embodiment, the first processing procedure includes:

In the step of pushing and rotating, after adding the first mixed raw material in the barrel, start the electromagnetic induction heating unit for heating, and start the push motor and reducer at the same time to make the drive shaft drive the propeller to rotate. The first mixed raw material is inside and outside the guiding tube A circulation flow path is formed between them.

In the first aeration step, set the temperature of the air flowing out of the gas heating device to 27°C to 32°C and open the third valve, the ventilation rate is 0.5vvm, the aeration unit is aerated, and the first mixed raw material is in the draft tube A circulating flow path is formed between the outside of the guide tube and the outside of the guide tube.

In the first temperature control step, when the temperature of the first mixed raw material is 30°C to 35°C, the electromagnetic induction heating unit is turned off, the propeller continues to rotate for 30min to 35min and the aeration unit continues to aerate for 30min to 35min.

Wherein, before the step of pushing and rotating, the first water inlet pipe and the first water outlet pipe are in a closed state.

Specifically, the first mixed raw material circulates along the circulation flow path between the inside and outside of the draft tube and gradually mixes evenly under the action of the propeller rotation and the air flow generated by the aeration head during the aeration process. At the same time, the temperature of the first mixed raw material is raised under the action of the hot air generated during the aeration process by the aeration head after the external air is heated by the gas heating device and the electromagnetic induction coil is energized. Thus, the oxygenation efficiency of the first liquid material is improved, and the amount of water to be evaporated in the subsequent evaporation section is reduced. Since the reducer reduces the rotation speed of the transmission shaft, thereby reducing the rotation speed of the propeller, and the structure of the propeller is conducive to pushing the first mixed raw material to flow along the axial direction of the guide tube, and its action on the first mixed raw material The shearing force is small, the cutting effect on the first mixed raw material is small, and the damage to the enzyme activity caused by high-speed stirring is avoided. The heating temperature generated by the energization of the electromagnetic induction coil can be precisely controlled, and there is no high temperature phenomenon that affects the enzyme activity, which improves the survival of the enzyme and reduces the loss of the enzyme.

After the external air is heated to 30°C to 35°C by the gas heating device, the third valve is opened, and the air at 30°C to 35°C enters the first air intake pipe with a ventilation volume of 0.5vvm, and the aerator head is used for aeration. Therefore, the oxygenation efficiency of the first mixed raw material is improved, and the temperature of the first mixed raw material is assisted.

In a specific embodiment, the second processing procedure includes:

In the second aeration step, add the second mixed raw material into the cylinder, the propeller continues to rotate, the aeration unit and the third valve continue to open, the gas heating device is turned off, and the normal temperature air enters the first air intake pipe and is aerated through the aeration unit gas.

In the cooling step, the first valve and the second valve are opened, and the external cooling water enters the first cooling water pipe through the first water inlet pipe and then flows out of the barrel through the first water outlet pipe.

In the second temperature control step, the flow controller dynamically adjusts the flow of cooling water according to the temperature value detected by the second temperature sensor, so as to maintain the temperature of the liquid in the barrel at 34°C to 41°C.

Wherein, in the second aeration step, the pressure of the normal temperature air is 0.15MPa, and the ventilation rate is 1.0vvm.

Specifically, the mixed liquid of the first liquid material and the second mixed raw material continues to flow along the circular flow between the inside of the guide tube and the outside of the guide tube under the action of the propulsion and rotation of the propeller and the airflow generated by the aeration head during the aeration process. The diameter of the air is circulated and gradually mixed evenly. The pressure of the normal temperature air is 0.15MPa, and the ventilation rate is 1.0vvm, which is beneficial to realize the uniform aeration of the mixed liquid of the first liquid material and the second mixed raw material, and increase the air and the first liquid. The contact area between the material and the mixed liquid of the second mixed raw material improves the oxygenation efficiency of the mixed liquid of the first liquid material and the second mixed raw material, and reduces the amount of water that needs to be evaporated in the subsequent evaporation section. Since the speed reducer reduces the rotation speed of the transmission shaft, thereby reducing the rotation speed of the propeller, and the structure of the propeller is conducive to pushing the mixed liquid of the first liquid material and the second mixed raw material to flow along the axis direction of the guide cylinder, and its The shearing force acting on the mixed solution of the first liquid material and the second mixed raw material is small, and the cutting effect on the liquid material is small, thereby avoiding damage to enzyme activity caused by high-speed stirring. The heating temperature generated by the energization of the electromagnetic induction coil can be precisely controlled, and there is no high temperature phenomenon that affects the enzyme activity, which improves the survival of the enzyme and reduces the loss of the enzyme.

The temperature of the liquid in the barrel is maintained at 34°C to 41°C, which is conducive to maintaining the survival of enzymes in the mixed liquid of the first liquid material and the second mixed raw material.

In a specific embodiment, the third processing procedure includes:

Stop the heating step, when the glucose content of the sample taken out is below 0.5%, close the first valve and the second valve, the propeller continues to rotate, the aeration unit and the third valve continue to open, the ventilation rate is 0.5vvm, and the electric valve is turned on simultaneously. Magnetic induction heating unit and gas heating device, when the temperature of the liquid material in the cylinder reaches above 60°C, close the gas heating device, aeration unit and the third valve, add unqualified zinc gluconate solid material, and the propeller continues to rotate, The electromagnetic induction heating unit continues to be turned on to maintain the temperature of the liquid in the barrel at 60°C to 65°C for 60min to 70min.

Stop promoting step, close described promoting motor and electromagnetic induction heating unit, and obtain zinc gluconate solution after propeller stops rotating.

Specifically, the target glucose content of the sample taken in the zinc gluconate production facility was 0.5% or less.

In the step of stopping heating, turn off the aeration unit when heating to the target temperature, add unqualified zinc gluconate solid material, and then maintain the temperature of the liquid in the cylinder at 60°C to 65°C for 60min to 70min, which can increase the glucose concentration. The quality and uniformity of the acid zinc solution are beneficial to the production and processing of the subsequent filtration section and evaporation section.

The invention improves oxygenation efficiency and performance. When the glucose concentration of the initial reaction material is the same as that of the traditional production method, the reaction time can be shortened, the production efficiency of the reaction section is improved, and the energy consumption and production cost are reduced. When the reaction time is the same as that of the traditional production method, the glucose concentration of the initial reaction material is high, and the reaction output material has a high concentration and low water content. The amount of water to be evaporated in the subsequent evaporation section is reduced, the evaporation time is shortened, and the energy consumption of the evaporation section is reduced. and production costs. And the heating temperature in the reaction process is precisely controlled, there is no high temperature phenomenon that affects the enzyme activity, the survival of the enzyme is improved, and the loss of the enzyme is reduced. Enzyme raw materials are expensive, which can reduce raw material consumption and production costs.

The above is only a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Anyone skilled in the art can easily think of changes or substitutions within the technical scope disclosed in the present invention. Should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.

Claims (10)

1. A method for preparing a zinc gluconate solution, which is characterized by comprising the following steps:

a step of preparing a first liquid material, which is to mix a first mixed raw material and then carry out a first treatment process through zinc gluconate production equipment to obtain the first liquid material;

a step of preparing a second liquid material, in which the first liquid material and a second mixed raw material are mixed in the zinc gluconate production equipment and then subjected to a second treatment process to obtain the second liquid material;

a step of obtaining zinc gluconate, wherein after a sample of the second liquid material is taken out from the zinc gluconate production equipment to reach a target glucose content, a zinc gluconate solution is obtained from the zinc gluconate production equipment through a third treatment process and is discharged;

the zinc gluconate production equipment comprises a cylinder body, wherein a feed inlet and a discharge outlet are respectively arranged on the cylinder body, a guide cylinder is arranged in the cylinder body, the guide cylinder and the cylinder body are supported by a first supporting unit, the cylinder body and the guide cylinder are simultaneously inserted by a part of pushing units, the cylinder body and a part of the first supporting unit are simultaneously connected with a cooling unit, a part of the cooling unit is positioned between the cylinder body and the guide cylinder, electromagnetic induction heating units are arranged outside the cylinder body and inside the cylinder body, the cylinder body is connected with an aeration unit, and a heat insulation layer is coated outside the cylinder body;

wherein the heating mode in the third treatment process is heating through the electromagnetic induction heating unit and the aeration unit, the aeration unit is closed when the temperature is heated to the target temperature, the electromagnetic induction heating unit is continuously started, and the temperature of the liquid in the cylinder is maintained at 61-67 ℃ for 60-70 min.

2. The method for producing a zinc gluconate solution according to claim 1,

the first mixed raw material comprises the following components in percentage by weight: water, dry glucose material and zinc oxide;

wherein, the glucose solution is obtained after the glucose dry material and the water are mixed, the concentration of the glucose solution is 35-50% (W/V), and the adding amount of the zinc oxide is 20-25% (W/W) of the glucose dry material;

the second mixed raw material comprises the following components in percentage by weight: glucose oxidase, catalase;

wherein, the addition amount of the glucose oxidase is 0.25-0.5% (W/W) of the dry glucose material, and the addition amount of the catalase is 0.15-0.25% (W/W) of the dry glucose material.

3. The method for preparing a zinc gluconate solution according to claim 2, wherein said first supporting unit comprises:

one end of each first support rod is connected with the guide cylinder, and the other end of each first support rod is connected with the inner wall of the cylinder;

one end of each second supporting rod is connected with the first supporting rod, and the other end of each second supporting rod is connected with the cooling unit.

4. The method for preparing a zinc gluconate solution according to claim 3, wherein said pushing unit comprises:

the pushing motor is arranged outside the cylinder body;

the speed reducer is arranged outside the cylinder and is connected with the pushing motor;

one end of the transmission shaft is connected with the speed reducer, and the other end of the transmission shaft is inserted into the cylinder body and the guide cylinder simultaneously;

and the propeller is connected with the end part of the transmission shaft far away from the speed reducer side and rotates in the guide cylinder.

5. The method for preparing a zinc gluconate solution according to claim 4, wherein said cooling unit comprises:

a plate member, an end of which is connected with the second support bar;

the first cooling water pipes are arranged between the adjacent plate pieces and are circumferentially distributed by taking the guide cylinder as a circle center;

one end of the first water inlet pipe is communicated with the end part of the first cooling water pipe far away from the ground surface side, and the other end of the first water inlet pipe penetrates out of the barrel to be connected with an external water pipe;

one end of the first water outlet pipe is communicated with the end part of the first cooling water pipe close to the ground side, and the other end of the first water outlet pipe penetrates out of the cylinder body to be connected with an external water pipe;

wherein,

a flow controller is arranged on the first water inlet pipe close to the inlet of the first water inlet pipe, and a first valve is arranged on the first water inlet pipe between the heat-insulating layer and the flow controller;

and a second valve is arranged on the first water outlet pipe positioned outside the cylinder body.

6. The method of preparing a zinc gluconate solution according to claim 5, wherein said electromagnetic induction heating unit comprises:

the electromagnetic induction coil is arranged on the outer surface of the heat insulation layer close to the guide cylinder;

a first temperature sensor disposed on the surface of the cylinder near the heat-insulating layer side;

the second temperature sensor is arranged on any one first supporting rod;

and the controller is used for controlling the electromagnetic induction coil and respectively receiving the temperature data acquired by the first temperature sensor and the second temperature sensor.

7. The method for preparing a zinc gluconate solution according to claim 6, wherein said aeration unit comprises:

one end of the first air inlet pipe is arranged in the cylinder body, and the other end of the first air inlet pipe penetrates out of the cylinder body and is communicated with the outside air;

the aeration heads are uniformly arranged on the first air inlet pipe in the cylinder, and the outlet of each aeration head faces the side of the guide cylinder;

the gas heating device is arranged on the first gas inlet pipe close to the inlet of the first gas inlet pipe;

the third valve is arranged on the first air inlet pipe between the gas heating device and the heat insulation layer;

wherein, a plurality of aeration heads are evenly distributed at the lower part of the cylinder body and are distributed in a circumference way.

8. The method of preparing a zinc gluconate solution according to claim 7, wherein said first treatment process comprises:

a pushing rotation step, namely, after the first mixed raw material is added into the cylinder, an electromagnetic induction heating unit is started to heat, and meanwhile, the pushing motor and the speed reducer are started to enable the transmission shaft to drive the propeller to rotate, so that a circulating flow path is formed between the inside and the outside of the guide cylinder by the first mixed raw material;

a first aeration step of setting the temperature of the air flowing out of the gas heating apparatus to 27 to 32 ℃ and opening the third valve, the aeration amount being 0.5vvm, the aeration unit performing aeration;

a first temperature control step, wherein when the temperature of the first mixed raw material is 30-35 ℃, the electromagnetic induction heating unit is closed, the propeller continuously rotates for 30-35 min, and the aeration unit continuously aerates for 30-35 min;

wherein, before the step of pushing rotation, the first water inlet pipe and the first water outlet pipe are in a closed state.

9. The method of preparing a zinc gluconate solution according to claim 8, wherein said second treatment process comprises:

a second aeration step of adding the second mixed raw material into the barrel, continuing to rotate the propeller, continuing to open the aeration unit and the third valve, closing the gas heating apparatus, and allowing normal-temperature air to enter the first air intake pipe and be aerated by the aeration unit;

a cooling step, namely opening the first valve and the second valve, and allowing external cooling water to enter the first cooling water pipe through the first water inlet pipe and then flow out of the cylinder through the first water outlet pipe;

a second temperature control step, wherein the flow controller dynamically adjusts the flow of the cooling water according to the temperature value detected by the second temperature sensor, so that the temperature of the liquid in the cylinder is maintained at 34-41 ℃;

wherein, in the second aeration step, the pressure of the normal temperature air is 0.15MPa, and the ventilation volume is 1.0vvm.

10. The method of producing a zinc gluconate solution according to claim 9, wherein said third treatment process comprises:

stopping heating, namely closing the first valve and the second valve when the glucose content of a taken sample is below 0.5%, continuing to rotate the propeller, continuing to open the aeration unit and the third valve, keeping the ventilation volume at 0.5vvm, simultaneously opening the electromagnetic induction heating unit and the gas heating device, closing the gas heating device, the aeration unit and the third valve when the temperature of the liquid material in the cylinder reaches above 60 ℃, adding substandard zinc gluconate solid material, continuing to rotate the propeller, continuing to open the electromagnetic induction heating unit, maintaining the temperature of the liquid in the cylinder at 60-65 ℃ and keeping the temperature for 60-70 min;

and a pushing stopping step of turning off the pushing motor and the electromagnetic induction heating unit and obtaining a zinc gluconate solution after the propeller stops rotating.

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