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CN115429250B - MRI (magnetic resonance imaging) gating method and system based on multi-channel pressure induction - Google Patents

MRI (magnetic resonance imaging) gating method and system based on multi-channel pressure induction Download PDF

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CN115429250B
CN115429250B CN202211402042.9A CN202211402042A CN115429250B CN 115429250 B CN115429250 B CN 115429250B CN 202211402042 A CN202211402042 A CN 202211402042A CN 115429250 B CN115429250 B CN 115429250B
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杜乙
岳海振
王若曦
耿建昊
朱向高
吴昊
彭亚辉
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Beijing Cancer Hospital
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Abstract

本申请公开了一种基于多通道压力感应的MRI门控方法及系统。其中方法包括,通过多个信号采集通道采集人体下体表与检查床接触面间的压力变化,以获取多个呼吸信号;对所述多个呼吸信号进行信号处理,以获取表征对应通道信号水平的多个推荐指标;所述推荐指标包括稳定度指标、灵敏度指标及信噪比指标;基于所述多个推荐指标从多个信号采集通道中选取符合预设要求的最优通道;基于最优通道采集到的呼吸信号进行MRI门控。本申请公开的方法及系统通过选取最优采集通道的呼吸信号进行MRI门控,可以提升MRI成像质量。

Figure 202211402042

The present application discloses an MRI gating method and system based on multi-channel pressure sensing. The method includes: collecting the pressure change between the lower body surface of the human body and the contact surface of the examination bed through multiple signal acquisition channels to obtain multiple respiratory signals; performing signal processing on the multiple respiratory signals to obtain signals representing the signal levels of the corresponding channels. multiple recommended indicators; the recommended indicators include stability indicators, sensitivity indicators and signal-to-noise ratio indicators; based on the multiple recommended indicators, select the optimal channel that meets the preset requirements from multiple signal acquisition channels; based on the optimal channel The acquired respiratory signal was gated by MRI. The method and system disclosed in the present application can improve the quality of MRI imaging by selecting the respiratory signal of the optimal acquisition channel for MRI gating.

Figure 202211402042

Description

一种基于多通道压力感应的MRI门控方法及系统MRI gating method and system based on multi-channel pressure sensing

技术领域technical field

本发明一般地涉及MRI门控领域。更具体地,本发明涉及一种基于多通道压力感应的MRI门控方法和一种基于多通道压力感应的MRI门控系统。The present invention relates generally to the field of MRI gating. More specifically, the present invention relates to an MRI gating method based on multi-channel pressure sensing and an MRI gating system based on multi-channel pressure sensing.

背景技术Background technique

现代医学中,利用MRI(磁共振成像)技术进行人体内部结构的成像。其利用核磁共振(nuclear magnetic resonance,简称NMR)原理,依据所释放的能量在物质内部不同结构环境中不同的衰减,通过外加梯度磁场检测所发射出的电磁波,即可得知构成这一物体原子核的位置和种类,据此可以绘制成物体内部的结构图像。In modern medicine, MRI (magnetic resonance imaging) technology is used to image the internal structure of the human body. It uses the principle of nuclear magnetic resonance (nuclear magnetic resonance, referred to as NMR), according to the different attenuation of the released energy in different structural environments inside the material, and through the detection of the emitted electromagnetic waves by an external gradient magnetic field, it can be known that the atomic nucleus that constitutes this object The position and type of the object can be drawn as a structural image inside the object.

在利用MRI进行成像过程中,需要利用患者呼吸信息,包括呼吸时相、呼吸周期信息进行MRI门控以成像。而呼吸信息的准确获取,是决定成像或治疗效果的重要因素。During the imaging process using MRI, it is necessary to use patient respiratory information, including respiratory phase and respiratory cycle information, to perform MRI gating for imaging. Accurate acquisition of respiratory information is an important factor in determining the effect of imaging or treatment.

在先申请CN201810399008.8(一种呼吸信息的获取方法及系统)中公开了可以通过采集人体下体表与检查床的压力变化,并通过模数转换后进行滤波来获取呼吸信号。然而,在实际的使用中由于患者体型的差异较大,不同通道间的测量值差异较大,使得呼吸测量的准确度不够。因此,如何提升MRI门控所需的呼吸信号的准确度,以提升MRI成像质量成为急需解决的问题。In the first application CN201810399008.8 (a method and system for obtaining respiratory information), it is disclosed that the respiratory signal can be obtained by collecting the pressure changes of the lower body surface of the human body and the examination bed, and filtering after analog-to-digital conversion. However, in actual use, due to the large difference in the size of the patient, the measurement value difference between different channels is large, so that the accuracy of the respiration measurement is not enough. Therefore, how to improve the accuracy of the respiratory signal required for MRI gating to improve the quality of MRI imaging has become an urgent problem to be solved.

发明内容Contents of the invention

为了至少解决上述背景技术部分所描述的技术问题,本发明提出了一种基于多通道压力感应的MRI门控方法及系统。利用本发明的方案,可以有效提高提升MRI门控所需的呼吸信号的准确度,从而提升MRI成像质量。鉴于此,本发明在如下的多个方面提供解决方案。In order to at least solve the technical problems described in the background technology section above, the present invention proposes an MRI gating method and system based on multi-channel pressure sensing. The solution of the present invention can effectively improve the accuracy of respiratory signals required for MRI gating, thereby improving the quality of MRI imaging. In view of this, the present invention provides solutions in the following aspects.

本发明的第一方面提供了一种基于多通道压力感应的MRI门控方法,包括;通过多个信号采集通道采集人体下体表与检查床接触面间的压力变化,以获取多个呼吸信号;对所述多个呼吸信号进行信号处理,以获取表征对应通道信号水平的多个推荐指标;所述推荐指标包括稳定度指标、灵敏度指标及信噪比指标;基于所述多个推荐指标从多个信号采集通道中选取符合预设要求的最优通道;基于最优通道采集到的呼吸信号进行MRI门控。The first aspect of the present invention provides an MRI gating method based on multi-channel pressure sensing, comprising: collecting pressure changes between the lower body surface of the human body and the contact surface of the examination bed through multiple signal acquisition channels to obtain multiple respiratory signals; Perform signal processing on the plurality of respiratory signals to obtain a plurality of recommended indicators representing the signal level of the corresponding channel; the recommended indicators include stability indicators, sensitivity indicators and signal-to-noise ratio indicators; based on the plurality of recommended indicators from multiple The optimal channel that meets the preset requirements is selected from the signal acquisition channels; the MRI gating is performed based on the respiratory signal collected by the optimal channel.

在一个实施例中,对所述多个呼吸信号进行信号处理,具体包括初级调理步骤和次级调理步骤;所述初级调理步骤用于降低所述多个呼吸信号的采样噪声,得到除噪呼吸信号;所述次级调理步骤用于根据所述除噪呼吸信号中的信号频率的不同得到所述多个推荐指标。In one embodiment, signal processing is performed on the multiple breathing signals, specifically including a primary conditioning step and a secondary conditioning step; the primary conditioning step is used to reduce the sampling noise of the multiple breathing signals to obtain noise-removed breathing signal; the secondary conditioning step is used to obtain the multiple recommended indicators according to the difference in signal frequency in the noise-removed respiratory signal.

在一个实施例中,所述初级调理步骤具体包括;使用高于人体呼吸频率的采样率进行压力值采样,对连续多个采样点进行平滑,以降低初试采样噪声。In one embodiment, the primary conditioning step specifically includes: sampling the pressure value at a sampling rate higher than the breathing frequency of the human body, and smoothing a plurality of consecutive sampling points, so as to reduce the noise of the preliminary sampling.

在一个实施例中,所述次级调理步骤具体包括;提取信号中直流与超低频率部分,定义为静态压力成分Fs;提取信号中超高频率部分,定义为测量信号的噪声成分Fn;提取信号中剩余的中频部分,作为动态压力成分Fd;使用静态压力成分Fs变化水平来表征患者是否有明显移动,作为稳定度推荐指标;使用静态压力成分Fs与动态压力成分Fd之间的比值,即Fd/Fs,来表征信号的测量灵敏度,作为灵敏度推荐指标;使用动态压力Fd与噪声成分Fn之间的计算关系,即10lg(Fd/Fn),来表征采集通道的信噪比,作为信噪比指标;所述超高频率为大于呼吸截止频率,所述超低频率为小于呼吸截止频率。In one embodiment, the secondary conditioning step specifically includes: extracting the direct current and ultra-low frequency part of the signal, defined as the static pressure component Fs; extracting the ultra-high frequency part of the signal, defined as the noise component Fn of the measurement signal; extracting the signal The rest of the intermediate frequency in the middle frequency is used as the dynamic pressure component Fd; the change level of the static pressure component Fs is used to represent whether the patient has obvious movement, which is used as a recommended indicator of stability; the ratio between the static pressure component Fs and the dynamic pressure component Fd is used, that is, Fd /Fs, to characterize the measurement sensitivity of the signal, as a recommended sensitivity index; use the calculation relationship between the dynamic pressure Fd and the noise component Fn, that is, 10lg(Fd/Fn), to characterize the signal-to-noise ratio of the acquisition channel, as the signal-to-noise ratio Index; the ultra-high frequency is greater than the respiratory cut-off frequency, and the ultra-low frequency is less than the respiratory cut-off frequency.

在一个实施例中,所述选取符合预设要求的最优通道,包括选择下列条件中的一个或多个进行门控成像:稳定度值最大;灵敏度值最大;信噪比值最大。In one embodiment, the selection of the optimal channel that meets the preset requirements includes selecting one or more of the following conditions for gated imaging: maximum stability, maximum sensitivity, and maximum signal-to-noise ratio.

本发明的第二方面提供了一种基于多通道压力感应的MRI门控系统,包括;压力采集模块,用于通过多个信号采集通道采集人体下体表与检查床接触面间的压力变化,以获取多个呼吸信号;信号处理模块,对所述多个呼吸信号进行信号处理,以获取表征对应通道信号水平的多个推荐指标;所述推荐指标包括稳定度指标、灵敏度指标及信噪比指标;通道选取模块,基于所述多个推荐指标从多个信号采集通道中选取符合预设要求的最优通道;MRI门控模块,基于最优通道采集到的呼吸信号进行MRI门控。The second aspect of the present invention provides an MRI gating system based on multi-channel pressure sensing, including; a pressure acquisition module, which is used to collect pressure changes between the lower body surface of the human body and the contact surface of the examination bed through multiple signal acquisition channels, to Acquire multiple respiratory signals; the signal processing module performs signal processing on the multiple respiratory signals to obtain multiple recommended indicators representing the signal level of the corresponding channel; the recommended indicators include stability indicators, sensitivity indicators and signal-to-noise ratio indicators The channel selection module selects the optimal channel that meets the preset requirements from multiple signal acquisition channels based on the multiple recommended indicators; the MRI gating module performs MRI gating based on the respiratory signal collected by the optimal channel.

在一个实施例中,对所述多个呼吸信号进行信号处理,具体包括初级调理步骤和次级调理步骤;所述初级调理步骤用于降低所述多个呼吸信号的采样噪声,得到除噪呼吸信号;所述次级调理步骤用于根据所述除噪呼吸信号中的信号频率的不同得到所述多个推荐指标。In one embodiment, signal processing is performed on the multiple breathing signals, specifically including a primary conditioning step and a secondary conditioning step; the primary conditioning step is used to reduce the sampling noise of the multiple breathing signals to obtain noise-removed breathing signal; the secondary conditioning step is used to obtain the multiple recommended indicators according to the difference in signal frequency in the noise-removed respiratory signal.

在一个实施例中,所述初级调理步骤具体包括;使用高于人体呼吸频率的采样率进行压力值采样,对连续多个采样点进行平滑,以降低初试采样噪声。In one embodiment, the primary conditioning step specifically includes: sampling the pressure value at a sampling rate higher than the breathing frequency of the human body, and smoothing a plurality of consecutive sampling points, so as to reduce the noise of the preliminary sampling.

在一个实施例中,所述次级调理步骤具体包括;提取信号中直流与超低频率部分,定义为静态压力成分Fs;提取信号中超高频率部分,定义为测量信号的噪声成分Fn;提取信号中剩余的中频部分,作为动态压力成分Fd;使用静态压力成分Fs变化水平来表征患者是否有明显移动,作为稳定度推荐指标;使用静态压力成分Fs与动态压力成分Fd之间的比值,即Fd/Fs,来表征信号的测量灵敏度,作为灵敏度推荐指标;使用动态压力Fd与噪声成分Fn之间的计算关系,即10lg(Fd/Fn),来表征采集通道的信噪比,作为信噪比指标;所述超高频率为大于呼吸截止频率,所述超低频率为小于呼吸截止频率。In one embodiment, the secondary conditioning step specifically includes: extracting the direct current and ultra-low frequency part of the signal, defined as the static pressure component Fs; extracting the ultra-high frequency part of the signal, defined as the noise component Fn of the measurement signal; extracting the signal The rest of the intermediate frequency in the middle frequency is used as the dynamic pressure component Fd; the change level of the static pressure component Fs is used to represent whether the patient has obvious movement, which is used as a recommended indicator of stability; the ratio between the static pressure component Fs and the dynamic pressure component Fd is used, that is, Fd /Fs, to characterize the measurement sensitivity of the signal, as a recommended sensitivity index; use the calculation relationship between the dynamic pressure Fd and the noise component Fn, that is, 10lg(Fd/Fn), to characterize the signal-to-noise ratio of the acquisition channel, as the signal-to-noise ratio Index; the ultra-high frequency is greater than the respiratory cut-off frequency, and the ultra-low frequency is less than the respiratory cut-off frequency.

在一个实施例中,所述选取符合预设要求的最优通道,包括选择下列条件中的一个或多个进行门控成像:稳定度值最大;灵敏度值最大;信噪比值最大。In one embodiment, the selection of the optimal channel that meets the preset requirements includes selecting one or more of the following conditions for gated imaging: maximum stability, maximum sensitivity, and maximum signal-to-noise ratio.

利用本发明所提供的方案,通过利用稳定度指标、灵敏度指标及信噪比指标来选取最优信号采集通道,并基于最优信号采集通道采集到的呼吸信号进行MRI门控。可以满足不同体型的患者的使用需求,提升了所采集的呼吸信号准确度,进而提升了MRI成像质量。Using the solution provided by the present invention, the optimal signal acquisition channel is selected by using the stability index, sensitivity index and signal-to-noise ratio index, and MRI gating is performed based on the respiratory signal collected by the optimal signal acquisition channel. It can meet the needs of patients of different sizes, improves the accuracy of the collected respiratory signals, and then improves the quality of MRI imaging.

附图说明Description of drawings

通过参考附图阅读下文的详细描述,本发明示例性实施方式的上述以及其他目的、特征和优点将变得易于理解。在附图中,以示例性而非限制性的方式示出了本发明的若干实施方式,并且相同或对应的标号表示相同或对应的部分,其中:The above and other objects, features and advantages of exemplary embodiments of the present invention will become readily understood by reading the following detailed description with reference to the accompanying drawings. In the drawings, several embodiments of the present invention are shown by way of illustration and not limitation, and the same or corresponding reference numerals indicate the same or corresponding parts, wherein:

图1是示出根据本发明实施例的多通道MRI门控方法示意图;FIG. 1 is a schematic diagram showing a multi-channel MRI gating method according to an embodiment of the present invention;

图2是示出根据本发明实施例的信号处理方法示意图;2 is a schematic diagram illustrating a signal processing method according to an embodiment of the present invention;

图3是示出根据本发明实施例的次级调理步骤方法示意图;Fig. 3 is a schematic diagram showing a secondary conditioning step method according to an embodiment of the present invention;

图4是示出根据本发明实施例的多通道MRI门控系统示意图。Fig. 4 is a schematic diagram showing a multi-channel MRI gating system according to an embodiment of the present invention.

具体实施方式Detailed ways

下面将结合本发明实施方式中的附图,对本发明实施方式中的技术方案进行清楚、完整地描述,显然,所描述的实施方式是本发明一部分实施方式,而不是全部的实施方式。基于本发明中的实施方式,本领域技术人员在没有做出创造性劳动前提下所获得的所有其他实施方式,都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by those skilled in the art without creative efforts shall fall within the protection scope of the present invention.

应当理解,本发明的权利要求、说明书及附图中的术语“第一”、“第二”、“第三”和“第四”等是用于区别不同对象,而不是用于描述特定顺序。本发明的说明书和权利要求书中使用的术语“包括”和“包含”指示所描述特征、整体、步骤、操作、元素和/或组件的存在,但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。It should be understood that the terms "first", "second", "third" and "fourth" in the claims, description and drawings of the present invention are used to distinguish different objects, rather than to describe a specific order . The terms "comprising" and "comprising" used in the description and claims of the present invention indicate the presence of described features, integers, steps, operations, elements and/or components, but do not exclude one or more other features, integers , steps, operations, elements, components, and/or the presence or addition of collections thereof.

还应当理解,在此本发明说明书中所使用的术语仅仅是出于描述特定实施方式的目的,而并不意在限定本发明。如在本发明说明书和权利要求书中所使用的那样,除非上下文清楚地指明其它情况,否则单数形式的“一”、“一个”及“该”意在包括复数形式。还应当进一步理解,在本发明说明书和权利要求书中使用的术语“和/或”是指相关联列出的项中的一个或多个的任何组合以及所有可能组合,并且包括这些组合。It should also be understood that the terms used in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention. As used in the specification and claims herein, the singular forms "a", "an" and "the" are intended to include the plural forms unless the context clearly dictates otherwise. It should be further understood that the term "and/or" used in the description and claims of the present invention refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations.

如在本说明书和权利要求书中所使用的那样,术语“如果”可以依据上下文被解释为“当... 时”或“一旦”或“响应于确定”或“响应于检测到”。类似地,短语“如果确定”或“如果检测到[所描述条件或事件]”可以依据上下文被解释为意指“一旦确定”或“响应于确定”或“一旦检测到[所描述条件或事件]”或“响应于检测到[所描述条件或事件]”。As used in this specification and claims, the term "if" may be construed as "when" or "once" or "in response to determining" or "in response to detecting" depending on the context. Similarly, the phrase "if determined" or "if [the described condition or event] is detected" may be construed, depending on the context, to mean "once determined" or "in response to the determination" or "once detected [the described condition or event] ]” or “in response to detection of [described condition or event]”.

下面结合附图来详细描述本发明的具体实施方式。The specific implementation manner of the present invention will be described in detail below in conjunction with the accompanying drawings.

本发明的第一方面,提供了一种基于多通道压力感应的MRI门控方法。图1是示出根据本发明一个实施例的多通道MRI门控方法示意图。本发明一种基于多通道压力感应的MRI门控方法,可以实施为如下描述的步骤S100-S400:The first aspect of the present invention provides an MRI gating method based on multi-channel pressure sensing. Fig. 1 is a schematic diagram illustrating a multi-channel MRI gating method according to an embodiment of the present invention. An MRI gating method based on multi-channel pressure sensing in the present invention can be implemented as steps S100-S400 as described below:

步骤S100,采集人体下体表与检查床接触面间的压力变化,以获取多个呼吸信号。Step S100, collect the pressure change between the lower body surface of the human body and the contact surface of the examination bed, so as to obtain multiple breathing signals.

本发明实施例中,通过多个信号采集通道采集人体下体表与检查床接触面间的压力变化。人体呼吸时,背部会有多个肌肉群协同参与,利用背部肌肉舒张与收缩过程与检查窗面产生的压力变化来表征呼吸状态。In the embodiment of the present invention, the pressure change between the lower body surface of the human body and the contact surface of the examination bed is collected through multiple signal collection channels. When the human body breathes, there will be multiple muscle groups in the back to participate in cooperation, and the breathing state is characterized by the relaxation and contraction process of the back muscles and the pressure changes generated by the inspection window.

在本发明一优选的实施例中,多个信号采集通道中应用压力传感器来感测呼吸时人体背部与检查床接触面的压力变化。其中压力传感器的布置方式可以是一个信号采集通道对应一个压力传感器,也可以是一个信号采集通道对应多个压力传感器或者是多个信号采集通道对应一个压力传感器。本发明中通过压力传感器的多通道网络化布置,以尽可能多的采集呼吸时人体背部与检查床接触面的压力变化数据,提升后续数据处理的准确性。In a preferred embodiment of the present invention, pressure sensors are used in multiple signal acquisition channels to sense pressure changes on the contact surface between the back of the human body and the examination table during breathing. The arrangement of the pressure sensors may be that one signal collection channel corresponds to one pressure sensor, or that one signal collection channel corresponds to multiple pressure sensors, or that multiple signal collection channels correspond to one pressure sensor. In the present invention, through the multi-channel network arrangement of the pressure sensors, as much pressure change data as possible on the contact surface between the back of the human body and the examination bed during breathing is collected to improve the accuracy of subsequent data processing.

在本发明一优选的实施例中,压力传感器可以安装或内嵌于检查床中,以减少患者穿脱仪器的步骤,提升患者就医体验;或者,压力传感器也可采取外置式,在需要时进行佩戴,在此配置情况下,可以方便医生对需要检查的重点部位进行调节,具有更高的灵活性。In a preferred embodiment of the present invention, the pressure sensor can be installed or embedded in the examination bed to reduce the steps for patients to put on and take off the instrument and improve the patient's medical experience; Wearing it, in this configuration, it is convenient for the doctor to adjust the key parts that need to be checked, and it has higher flexibility.

在本发明一优选的实施例中,根据采集得到的压力信号,系统对上述压力信号进行模数转换,比如,采用模数转换器进行模拟数字信号的转换,即将采集到的上述模拟压力信号转换为数字信号,即为初始的呼吸信号。In a preferred embodiment of the present invention, according to the collected pressure signal, the system performs analog-to-digital conversion on the above-mentioned pressure signal. is a digital signal, that is, the initial breathing signal.

步骤S200,对所述多个呼吸信号进行信号处理,以获取表征对应通道信号水平的多个推荐指标。Step S200, performing signal processing on the plurality of respiratory signals to obtain a plurality of recommended indicators representing signal levels of corresponding channels.

本发明实施例中,获取到初始的呼吸信号后需要进行数字信号处理,得到推荐指标。所述推荐指标包括稳定度指标、灵敏度指标及信噪比指标。其中,稳定度指标用于表征患者是否有明显移动,该信号通道是否稳定,可以预料的,若检查过程患者有明显移动会影响到MRI成像的清晰度;灵敏度指标用于表征信号的测量灵敏度,可以预料的,若该采集通道的灵敏度较低会影响到MRI成像的质量;信噪比指标用于表征该信道信噪比,可以预料的,若该采集通道的信噪比较低会影响到MRI成像的速度。In the embodiment of the present invention, digital signal processing needs to be performed after the initial respiratory signal is acquired to obtain the recommended index. The recommended indexes include stability indexes, sensitivity indexes and signal-to-noise ratio indexes. Among them, the stability index is used to represent whether the patient has obvious movement, and whether the signal channel is stable. It is predictable that if the patient has obvious movement during the examination process, it will affect the clarity of the MRI imaging; the sensitivity index is used to represent the measurement sensitivity of the signal. It can be expected that if the sensitivity of the acquisition channel is low, it will affect the quality of MRI imaging; the signal-to-noise ratio index is used to characterize the signal-to-noise ratio of the channel. It can be expected that if the signal-to-noise ratio of the acquisition channel is low, it will affect the quality of MRI imaging. The speed of MRI imaging.

在本发明一优选的实施例中,对所述多个呼吸信号进行信号处理包括初级调理步骤和次级调理步骤。请参见图2,图2是示出根据本发明一个实施例的对呼吸信号进行信号处理方法示意图,可以实施为如下描述的步骤S210-S220:In a preferred embodiment of the present invention, performing signal processing on the plurality of respiratory signals includes a primary conditioning step and a secondary conditioning step. Please refer to FIG. 2. FIG. 2 is a schematic diagram showing a signal processing method for a respiratory signal according to an embodiment of the present invention, which can be implemented as steps S210-S220 as described below:

步骤S210,初级调理步骤,用于降低所述多个呼吸信号的采样噪声,得到除噪呼吸信号;Step S210, a primary conditioning step, for reducing the sampling noise of the plurality of respiratory signals to obtain denoised respiratory signals;

在本发明一优选的实施例中,初级信号调理步骤目的是进行初步信号的平滑。由于人体呼吸周期大约为3-6秒/每次,可以通过使用高采样率,如50Hz进行压力值采样(采样间隔为40ms),对连续多个采样点(如5个采样点)进行平滑(或中值滤波),以降低初试采样噪声。In a preferred embodiment of the invention, the primary signal conditioning step aims at smoothing the primary signal. Since the breathing cycle of the human body is about 3-6 seconds per time, you can use a high sampling rate, such as 50Hz for pressure value sampling (sampling interval is 40ms), to smooth multiple continuous sampling points (such as 5 sampling points) ( or median filter) to reduce the initial sampling noise.

步骤S220,次级调理步骤,用于根据所述除噪呼吸信号中的信号频率的不同得到所述多个推荐指标。Step S220, a secondary conditioning step, used to obtain the multiple recommended indicators according to the difference in signal frequency in the noise-removed respiratory signal.

在本发明一优选的实施例中,次级调理步骤具体参见图3。图3是示出根据本发明一个实施例的次级调理步骤方法示意图,可以实施为如下描述的步骤S221-S226。In a preferred embodiment of the present invention, refer to FIG. 3 for details of the secondary conditioning steps. Fig. 3 is a schematic diagram illustrating a method of secondary conditioning steps according to an embodiment of the present invention, which may be implemented as steps S221-S226 as described below.

步骤S221,提取信号中直流与超低频率部分,定义为静态压力成分Fs;Step S221, extracting the direct current and ultra-low frequency part of the signal, which is defined as the static pressure component Fs;

步骤S222,提取信号中超高频率部分,定义为测量信号的噪声成分Fn;Step S222, extracting the ultrahigh frequency part in the signal, defined as the noise component Fn of the measurement signal;

步骤S223,提取信号中剩余的中频部分,定义为动态压力成分Fd。Step S223, extracting the remaining intermediate frequency part in the signal, which is defined as the dynamic pressure component Fd.

在根据信号频率的不同,提取到需要的信号后,还需要对信号进行处理,以获取表征各采集通道信号水平的多个推荐指标,具体信号处理的过程如下:After the required signal is extracted according to the different signal frequencies, the signal needs to be processed to obtain multiple recommended indicators representing the signal level of each acquisition channel. The specific signal processing process is as follows:

步骤S224,使用静态压力成分Fs变化水平来表征患者是否有明显移动,作为稳定度推荐指标;Step S224, using the change level of the static pressure component Fs to characterize whether the patient has obvious movement, as a recommended indicator of stability;

步骤S225,使用静态压力成分Fs与动态压力成分Fd之间的比值,即Fd/Fs,来表征信号的测量灵敏度,作为灵敏度推荐指标;Step S225, using the ratio between the static pressure component Fs and the dynamic pressure component Fd, that is, Fd/Fs, to characterize the measurement sensitivity of the signal, as a sensitivity recommendation index;

步骤S226,使用动态压力Fd与噪声成分Fn之间的计算关系,即10lg(Fd/Fn),来表征采集通道的信噪比,作为信噪比指标。Step S226, using the calculation relationship between the dynamic pressure Fd and the noise component Fn, ie, 10lg(Fd/Fn), to characterize the signal-to-noise ratio of the acquisition channel as the signal-to-noise ratio index.

需要注意的是,超高频率及超低频率是相对于正常呼吸频率范围来比较的。人体呼吸周期大约为3-6秒/每次。例如,若大于如0.5Hz,(即呼吸周期为2s/每次)可以判断为超高频率。具体超高频率及超低频率的值在本发明中不作具体限定,凡是认为超出正常呼吸频率范围内的频率,在合理范围内,都可被视为超高频率及超低频率。It should be noted that the ultra-high frequency and ultra-low frequency are compared relative to the normal respiratory frequency range. The human breathing cycle is about 3-6 seconds/time. For example, if it is greater than 0.5Hz (that is, the breathing cycle is 2s/each time), it can be judged as an ultra-high frequency. The specific values of ultra-high frequency and ultra-low frequency are not specifically limited in the present invention, and any frequency considered to exceed the range of normal respiratory frequency can be regarded as ultra-high frequency and ultra-low frequency within a reasonable range.

以下继续回到图1。步骤S300,基于所述多个推荐指标从多个信号采集通道中选取符合预设要求的最优通道。Continue to return to Figure 1 below. Step S300, selecting an optimal channel that meets preset requirements from multiple signal acquisition channels based on the multiple recommended indicators.

本发明实施例中,考虑到患者体型差异较大,当利用获取到的呼吸信号进行MRI门控时,会出现在测量结果差异较大。例如,当测量体重过大患者,静态力Fs有可能过大、信号幅度Fd相对较小,从而测量灵敏度Fs/Fd较小;反之,过瘦患者,尽管测量灵敏较高,但有可能测量信噪比较差。因而,需要根据不同的患者体型,选择符合预设要求的采集通道的测量结果,以保证呼吸信号的准确度。In the embodiment of the present invention, considering the large difference in the size of the patients, when the obtained respiratory signal is used for MRI gating, there will be a large difference in the measurement results. For example, when measuring an overweight patient, the static force Fs may be too large and the signal amplitude Fd is relatively small, so the measurement sensitivity Fs/Fd is small; on the contrary, for an overweight patient, although the measurement sensitivity is high, the measurement signal may be The noise ratio is poor. Therefore, according to different patient sizes, it is necessary to select the measurement results of the acquisition channels that meet the preset requirements, so as to ensure the accuracy of the respiratory signal.

在本发明一优选的实施例中,所述选取符合预设要求的最优通道,包括选择下列条件中的一个或多个进行门控成像:稳定度值最大,灵敏度值最大,信噪比值最大。可以理解的,选择最优通道时,需要根据患者的实际体型进行调整,例如检测较胖的患者可以选取信噪比最高和/或灵敏度最高的通道所采集的呼吸信号进行门控;而针对过瘦的患者可以选取稳定性最高和/或信噪比最高的通道所采集的呼吸信号进行门控。本发明通过推荐指标进行最终信号通道的人工选择或自动选择,如根据偏好人工或自动选择最稳定/灵敏/信噪比最优通道,用于后续门控成像,使得适用患者人群(身高、体重、体格)更广。In a preferred embodiment of the present invention, the selection of the optimal channel that meets the preset requirements includes selecting one or more of the following conditions for gated imaging: maximum stability value, maximum sensitivity value, signal-to-noise ratio value maximum. It can be understood that when selecting the optimal channel, it needs to be adjusted according to the actual body size of the patient. For example, to detect a fat patient, the respiratory signal collected by the channel with the highest signal-to-noise ratio and/or the highest sensitivity can be selected for gating; For thin patients, the respiration signal acquired by the channel with the highest stability and/or the highest signal-to-noise ratio can be selected for gating. The present invention performs manual selection or automatic selection of the final signal channel through recommended indicators, such as manual or automatic selection of the most stable/sensitive/optimal signal-to-noise ratio channel according to preferences, for subsequent gated imaging, making it suitable for patient populations (height, weight , physique) wider.

步骤S400,基于最优通道采集到的呼吸信号进行MRI门控。Step S400, performing MRI gating based on the respiratory signal collected by the optimal channel.

本发明实施例中,将最优通道采集到的呼吸信号传输给MRI控制器,使得MRI控制器利用上述最优通道采集到的呼吸信号进行MRI门控。In the embodiment of the present invention, the respiratory signal collected by the optimal channel is transmitted to the MRI controller, so that the MRI controller uses the respiratory signal collected by the optimal channel to perform MRI gating.

基于图1、图2和图3所描述的一种基于多通道压力感应的MRI门控方法,本发明的第二方面还提供了基于多通道压力感应的MRI门控系统;该MRI门控系统可以实施图1、图2和图3所描述的一种基于多通道压力感应的MRI门控方法,从而达到通过多个推荐指标来获取最优采集通道获取的呼吸信号,来进行MRI门控的目的;如图4所示,本发明一种呼吸信息的获取系统包括:Based on the multi-channel pressure sensing-based MRI gating method described in Fig. 1, Fig. 2 and Fig. 3, the second aspect of the present invention also provides an MRI gating system based on multi-channel pressure sensing; the MRI gating system An MRI gating method based on multi-channel pressure sensing described in Figure 1, Figure 2 and Figure 3 can be implemented, so as to obtain the respiratory signal obtained by the optimal acquisition channel through multiple recommended indicators for MRI gating Purpose; As shown in Figure 4, the acquisition system of a kind of breathing information of the present invention comprises:

压力采集模块100,用于通过多个信号采集通道采集人体下体表与检查床接触面间的压力变化,以获取多个呼吸信号;The pressure collection module 100 is used to collect pressure changes between the lower body surface of the human body and the contact surface of the examination bed through multiple signal collection channels, so as to obtain multiple breathing signals;

信号处理模块200,对所述多个呼吸信号进行信号处理,以获取表征对应通道信号水平的多个推荐指标;所述推荐指标包括稳定度指标、灵敏度指标及信噪比指标;The signal processing module 200 performs signal processing on the plurality of respiratory signals to obtain a plurality of recommended indicators representing the signal level of the corresponding channel; the recommended indicators include stability indicators, sensitivity indicators and signal-to-noise ratio indicators;

通道选取模块300,基于所述多个推荐指标从多个信号采集通道中选取符合预设要求的最优通道;The channel selection module 300, based on the multiple recommended indicators, selects the optimal channel that meets the preset requirements from multiple signal acquisition channels;

MRI门控模块400,基于最优通道采集到的呼吸信号进行MRI门控。The MRI gating module 400 performs MRI gating based on the respiratory signal collected by the optimal channel.

在本发明一优选的实施例中,所述对所述多个呼吸信号进行信号处理,具体包括初级调理步骤和次级调理步骤;In a preferred embodiment of the present invention, the signal processing of the plurality of respiratory signals specifically includes a primary conditioning step and a secondary conditioning step;

所述初级调理步骤用于降低所述多个呼吸信号的采样噪声,得到除噪呼吸信号;The primary conditioning step is used to reduce the sampling noise of the plurality of respiratory signals to obtain denoised respiratory signals;

所述次级调理步骤用于根据所述除噪呼吸信号中的信号频率的不同得到所述多个推荐指标。The secondary conditioning step is used to obtain the multiple recommended indexes according to the signal frequency difference in the noise-removed respiratory signal.

在本发明一优选的实施例中,所述初级调理步骤具体包括;In a preferred embodiment of the present invention, the primary conditioning step specifically includes;

使用高于人体呼吸频率的采样率进行压力值采样,对连续多个采样点进行平滑,以降低初试采样噪声。Use a sampling rate higher than the human respiratory frequency to sample the pressure value, and smooth multiple consecutive sampling points to reduce the initial sampling noise.

在本发明一优选的实施例中,所述次级调理步骤具体包括;In a preferred embodiment of the present invention, the secondary conditioning step specifically includes;

提取信号中直流与超低频率部分,定义为静态压力成分Fs;Extract the DC and ultra-low frequency part of the signal, which is defined as the static pressure component Fs;

提取信号中超高频率部分,定义为测量信号的噪声成分Fn;Extract the ultra-high frequency part of the signal, which is defined as the noise component Fn of the measurement signal;

提取信号中剩余的中频部分,定义为动态压力成分Fd;Extract the remaining intermediate frequency part of the signal, which is defined as the dynamic pressure component Fd;

使用静态压力成分Fs变化水平来表征患者是否有明显移动,作为稳定度推荐指标;Use the change level of the static pressure component Fs to characterize whether the patient has significant movement, as a recommended indicator of stability;

使用静态压力成分Fs与动态压力成分Fd之间的比值,即Fd/Fs,来表征信号的测量灵敏度,作为灵敏度推荐指标;Use the ratio between the static pressure component Fs and the dynamic pressure component Fd, that is, Fd/Fs, to characterize the measurement sensitivity of the signal, as a recommended index for sensitivity;

使用动态压力Fd与噪声成分Fn之间的计算关系,即10lg(Fd/Fn),来表征该信道信噪比,作为信噪比指标;Use the calculation relationship between the dynamic pressure Fd and the noise component Fn, that is, 10lg(Fd/Fn), to characterize the signal-to-noise ratio of the channel as the signal-to-noise ratio index;

所述超高频率为大于呼吸截止频率,所述超低频率为小于呼吸截止频率。The ultra-high frequency is greater than the respiratory cut-off frequency, and the ultra-low frequency is less than the respiratory cut-off frequency.

在本发明一优选的实施例中,所述选取符合预设要求的最优通道,包括选择下列条件中的一个或多个进行门控成像:In a preferred embodiment of the present invention, the selection of the optimal channel that meets the preset requirements includes selecting one or more of the following conditions for gated imaging:

稳定度值最大;The maximum value of stability;

灵敏度值最大;The maximum sensitivity value;

信噪比值最大。The signal-to-noise ratio is the largest.

虽然本说明书已经示出和描述了本发明的多个实施方式,但对于本领域技术人员显而易见的是,这样的实施方式是仅以示例的方式提供的。本领域技术人员在不偏离本发明思想和精神的情况下想到许多更改、改变和替代的方式。应当理解在实践本发明的过程中,可以采用本文所描述的本发明实施方式的各种替代方案。所附权利要求书旨在限定本发明的保护范围,并因此覆盖这些权利要求范围内的模块组成、等同或替代方案。While various embodiments of the invention have been illustrated and described, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Many modifications, changes and substitutions will occur to those skilled in the art without departing from the idea and spirit of the present invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the appended claims define the scope of the invention and therefore cover modular compositions, equivalents or alternatives within the scope of these claims.

Claims (2)

1. An MRI gating method based on multi-channel pressure induction is characterized by comprising the following steps of;
acquiring pressure change between the lower body surface of a human body and a contact surface of an examination bed through a plurality of signal acquisition channels to acquire a plurality of respiratory signals;
performing signal processing on the plurality of respiratory signals to obtain a plurality of recommendation indexes representing signal levels of corresponding channels; the recommendation indexes comprise stability indexes, sensitivity indexes and signal-to-noise ratio indexes;
selecting an optimal channel meeting preset requirements from a plurality of signal acquisition channels based on the plurality of recommendation indexes;
performing MRI gating on the basis of respiratory signals acquired by the optimal channel;
performing signal processing on the plurality of respiratory signals, wherein the signal processing specifically comprises a primary conditioning step and a secondary conditioning step;
the primary conditioning step is used for reducing the sampling noise of the plurality of respiratory signals to obtain noise-removed respiratory signals;
the secondary conditioning step is used for obtaining the plurality of recommended indexes according to different signal frequencies in the de-noising breathing signal;
the primary conditioning step specifically comprises;
sampling pressure values by using a sampling rate higher than the respiratory frequency of a human body, and smoothing a plurality of continuous sampling points to reduce initial sampling noise;
the secondary conditioning step specifically comprises;
extracting direct current and ultralow frequency parts in the signal, and defining the parts as static pressure components Fs;
extracting an ultrahigh frequency part in the signal, and defining the ultrahigh frequency part as a noise component Fn of the measurement signal;
extracting the residual intermediate frequency part in the signal, and defining the residual intermediate frequency part as a dynamic pressure component Fd;
using the variation level of the static pressure component Fs to represent whether the patient has obvious movement or not as a stability recommendation index;
using the ratio between the static pressure component Fs and the dynamic pressure component Fd, namely Fd/Fs, to represent the measurement sensitivity of the signal, and using the measurement sensitivity as a sensitivity recommendation index;
using a calculation relation between the dynamic pressure Fd and the noise component Fn, namely 10lg (Fd/Fn), to represent the signal-to-noise ratio of the acquisition channel as a signal-to-noise ratio index;
the ultra-high frequency is greater than the respiratory cut-off frequency, and the ultra-low frequency is less than the respiratory cut-off frequency;
the selecting of the optimal channel meeting the preset requirements comprises selecting one or more of the following conditions for gated imaging:
the stability value is maximum;
the sensitivity value is maximum;
the signal-to-noise ratio is the largest.
2. An MRI gating system based on multi-channel pressure sensing, comprising;
the pressure acquisition module is used for acquiring pressure change between the contact surface of the lower body surface of the human body and the examination bed through a plurality of signal acquisition channels so as to acquire a plurality of respiratory signals;
the signal processing module is used for carrying out signal processing on the plurality of respiratory signals so as to obtain a plurality of recommendation indexes representing corresponding channel signal levels; the recommendation indexes comprise stability indexes, sensitivity indexes and signal-to-noise ratio indexes;
the channel selection module is used for selecting an optimal channel which meets the preset requirement from a plurality of signal acquisition channels based on the recommendation indexes;
the MRI gating module is used for performing MRI gating on the basis of the respiratory signals acquired by the optimal channel;
performing signal processing on the plurality of respiratory signals, wherein the signal processing specifically comprises a primary conditioning step and a secondary conditioning step;
the primary conditioning step is used for reducing the sampling noise of the plurality of respiratory signals to obtain noise-removed respiratory signals;
the secondary conditioning step is used for obtaining the plurality of recommendation indexes according to different signal frequencies in the de-noising breathing signal;
the primary conditioning step specifically comprises;
sampling pressure values by using a sampling rate higher than the respiratory frequency of a human body, and smoothing a plurality of continuous sampling points to reduce initial sampling noise;
the secondary conditioning step specifically comprises;
extracting direct current and ultralow frequency parts in the signal, and defining the parts as static pressure components Fs;
extracting an ultrahigh frequency part in the signal, and defining the ultrahigh frequency part as a noise component Fn of the measurement signal;
extracting the residual intermediate frequency part in the signal, and defining the residual intermediate frequency part as a dynamic pressure component Fd;
using the variation level of the static pressure component Fs to represent whether the patient has obvious movement or not as a stability recommendation index;
using the ratio between the static pressure component Fs and the dynamic pressure component Fd, namely Fd/Fs, to represent the measurement sensitivity of the signal, and using the measurement sensitivity as a sensitivity recommendation index;
the signal-to-noise ratio of an acquisition channel is represented by using a calculation relation between the dynamic pressure Fd and the noise component Fn, namely 10lg (Fd/Fn), and is used as a signal-to-noise ratio index;
the ultra-high frequency is greater than the respiratory cut-off frequency, and the ultra-low frequency is less than the respiratory cut-off frequency;
the selecting of the optimal channel meeting the preset requirements comprises selecting one or more of the following conditions for gated imaging:
the stability value is maximum;
the sensitivity value is maximum;
the signal-to-noise ratio is the largest.
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