CN115444542A - Left atrial appendage blockage ablation device - Google Patents

Abstract

The invention relates to a left atrial appendage occlusion ablation device. Left atrial appendage shutoff ablation device includes: the anchoring disc is of a radial telescopic support structure; the sealing disc is of a radial telescopic support structure and is arranged at the near end of the anchoring disc; the sealing disc is made of a conductive material, and the whole sealing disc is used as a first conductive part for transmitting ablation energy or collecting tissue physiological signals. The anchoring disc is released in the left auricle, the anchoring disc can anchor the inner wall of the tissue of the left auricle, and the sealing disc is released at the entrance of the left auricle, so that the sealing disc blocks the entrance of the left auricle, blocks thrombus in the left auricle and effectively prevents the thrombus from entering the left atrium. Simultaneously the whole electrically conductive and transmission of sealed dish melts the energy, melts left auricle portion, more is favorable to melting the area at the complete ring-shaped of oral area formation, and then is convenient for thoroughly keep apart left auricle and left atrium electricity at left auricle portion, greatly improves and melts the effect.

Description

Left atrial appendage blockage ablation device

technical field

The invention relates to the technical field of interventional medical devices, in particular to a left atrial appendage blockage ablation device.

Background technique

Atrial fibrillation (abbreviated as atrial fibrillation) is the most common sustained arrhythmia, and with age, the incidence of atrial fibrillation continues to increase, reaching 10% in people over 75 years old. The prevalence of atrial fibrillation is also closely related to diseases such as coronary heart disease, hypertension and heart failure. Due to its special shape and structure, the left atrial appendage is not only the most important site for atrial fibrillation thrombosis, but also one of the key areas for its occurrence and maintenance. Some patients with atrial fibrillation can benefit from active left atrial appendage electrical isolation.

Many cases of atrial fibrillation have been successfully treated using the one-stop treatment method of combined catheter radiofrequency ablation and left atrial appendage occlusion. At present, many cases of atrial fibrillation have been successfully treated by using a one-stop treatment method combining catheter radiofrequency ablation and left atrial appendage closure. In the one-stop treatment method, through the closure of the left atrial appendage, patients can still obtain good stroke prevention effects without taking anticoagulant drugs for life; combined with catheter radiofrequency ablation to restore and maintain sinus rhythm and improve patients with atrial fibrillation Symptoms can enable patients to obtain stable long-term therapeutic effects. However, in order to perform ablation and closure of the left atrial appendage during the above-mentioned one-stop treatment, it is necessary to introduce an ablation catheter and a closure and ablation device for the left atrial appendage in an interventional manner. The key is to position the two devices successively on the left At the mouth of the atrial appendage, ablation and occlusion are performed separately. Since the ablation catheter and the occlusion of the left atrial appendage are difficult to locate at the mouth of the left atrial appendage, the surgical procedure is complicated and time-consuming, which is not conducive to improving the "ablation + left atrial appendage occlusion" "The convenience of one-stop treatment and surgery.

Contents of the invention

The purpose of the present invention is to provide a left atrial appendage occlusion ablation device, which can effectively improve the technical problem of "ablation + left atrial appendage occlusion" one-stop treatment operation procedure is complicated and difficult in the prior art.

In order to solve the problems of the technologies described above, the present invention adopts the following technical solutions:

An embodiment of the present invention provides a left atrial appendage blockage ablation device, the left atrial appendage blockage ablation device includes: an anchoring disc, which is a radially expandable stent structure; and a sealing disc, which is radially expandable The stent structure is arranged at the proximal end of the anchoring disk; the sealing disk is made of conductive material, and the sealing disk as a whole serves as a first conductive part for transmitting ablation energy or collecting tissue physiological signals.

According to some embodiments of the present application, the left atrial appendage blockage ablation device further includes a second conductive part, and the second conductive part is respectively used to transmit ablation energy or collect tissue physiological signals; the second conductive part is arranged on the on the anchor disk; the sealing disk is electrically isolated from the second conductive part.

It can be seen from the above technical solutions that the embodiments of the present invention have at least the following advantages and positive effects:

The left atrial appendage occlusion ablation device provided by the embodiment of the present invention includes an anchoring disc and a sealing disc; The disc can be anchored to the tissue inner wall of the left atrial appendage, released at the entrance of the left atrial appendage by using the sealing disc, and the sealing disc can be used to block the entrance of the left atrial appendage, block the thrombus inside the left atrial appendage, and effectively prevent the thrombus from entering the left atrium. At the same time, the sealing disk conducts electricity as a whole and acts as the first conductive part to transmit ablation energy. For the ablation of the mouth of the left atrial appendage, it is more conducive to forming a complete ring-shaped ablation zone at the mouth of the left atrial appendage. The electrical isolation of the atrium greatly improves the ablation effect. The sealing disc, as the first conductive part, can also be used to collect tissue physiological signals for mapping. In addition, the left atrial appendage occlusion ablation device combines ablation and occlusion, which simplifies the procedure of "ablation + left atrial appendage occlusion" one-stop treatment and helps reduce the difficulty of surgery.

Description of drawings

FIG. 1 is a schematic structural view of the left atrial appendage occlusion ablation device provided by Embodiment 1 of the present invention.

Fig. 2 is a schematic cross-sectional structure diagram of the left atrial appendage occlusion ablation device provided by Embodiment 1 of the present invention.

Fig. 3 is an enlarged schematic diagram of the local structure at III in Fig. 2 .

Fig. 4 is a schematic structural diagram of the conveyor provided by Embodiment 1 of the present invention.

FIG. 5 is a schematic structural diagram of the first skeleton in FIG. 2 .

FIG. 6 is a schematic structural view of the insulating connector in the left atrial appendage blockage ablation device provided by Embodiment 2 of the present invention.

Fig. 7 is a schematic structural view of the insulating connector in the left atrial appendage blockage ablation device provided by Embodiment 3 of the present invention.

Fig. 8 is a schematic structural view of the insulating connector in the left atrial appendage blockage ablation device provided by Embodiment 4 of the present invention.

Fig. 9 is a schematic structural view of the insulating connector in the left atrial appendage blockage ablation device provided by Embodiment 5 of the present invention.

FIG. 10 is a schematic structural view of the insulated connector of the left atrial appendage occlusion ablation device in FIG. 9 when stretched and twisted.

Fig. 11 is a schematic structural diagram of the left atrial appendage occlusion ablation device provided by Embodiment 6 of the present invention.

FIG. 12 is a schematic cross-sectional structure diagram of the left atrial appendage occlusion ablation device in FIG. 11 after the film is removed.

Fig. 13 is a schematic structural view of the left atrial appendage occlusion ablation device provided by Embodiment 7 of the present invention.

Fig. 14 is a schematic structural view of the left atrial appendage occlusion ablation device provided by Embodiment 8 of the present invention.

Fig. 15 is a schematic structural diagram of the left atrial appendage blockage ablation device provided by Embodiment 9 of the present invention.

FIG. 16 is a schematic structural view of the left atrial appendage occlusion ablation device in FIG. 15 after the film is removed.

Fig. 17 is a schematic structural diagram of the left atrial appendage blockage ablation device provided by Embodiment 10 of the present invention.

FIG. 18 is a schematic structural view of the left atrial appendage occlusion ablation device in FIG. 17 after the film is removed.

Fig. 19 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 11 of the present invention.

FIG. 20 is a schematic structural view of the left atrial appendage occlusion ablation device in FIG. 19 after the film is removed.

Fig. 21 is a schematic structural view of the left atrial appendage occlusion ablation device provided by Embodiment 12 of the present invention after removing the covering film.

Fig. 22 is a schematic structural view of the first frame in the left atrial appendage blockage ablation device shown in Fig. 21 .

Fig. 23 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 13 of the present invention.

Fig. 24 is a schematic structural diagram of the left atrial appendage blockage ablation device provided by Embodiment 14 of the present invention.

FIG. 25 is a schematic structural view of the left atrial appendage occlusion ablation device in FIG. 24 after the film is removed.

Fig. 26 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 15 of the present invention.

Fig. 27 is a schematic structural diagram of the movable part in Fig. 26 .

Fig. 28 is a schematic diagram of the second structure of the movable part in Fig. 26 .

Fig. 29 is a schematic diagram of the third structure of the movable part in Fig. 26 .

Fig. 30 is a schematic diagram of the fourth structure of the movable part in Fig. 26 .

Fig. 31 is a schematic diagram of the fifth structure of the movable part in Fig. 26 .

Fig. 32 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 16 of the present invention.

Fig. 33 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 17 of the present invention.

Fig. 34 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 18 of the present invention.

Description of drawings: 100, ablation bracket; 110, anchoring plate; 111, first frame; 112, support part; 1121, support rod; 1122, first branch; 1123, second branch; 1124, first connection point; 113. Anchoring part; 1131. Connecting rod; 1132. Third branch; 1133. Fourth branch; 1134. Second connection point; 114. Second conductive part; 116. First electrode part; 117. Barb; 118 , connection ring; 119, distal connector; 120, sealing disc; 121, second skeleton; 122, first conductive part; 123, second electrode part; 124, second conductive connection part; 125, insulating film; 126 , choke film; 127, disk surface; 128, disk bottom; 129, waist; 130, insulating connector; 131, first connector; 1311, first installation space; 132, second connector; 1321, inner sleeve 1322, outer sleeve; 1323, second installation space; 133, third connector; 1331, large pipe section; 1332, small pipe section; 134, first conductive connection part; 135, fourth connector; 140, conveyor ; 141, the second catheter; 142, the first catheter; 143, the outer tube; 144, the handle; 150, the movable part; ; 1521, the first pole; 1522, the second pole; 1523, the first connecting rod; 1524, the second connecting rod; 1525, the third connecting point; 153, the pipe body; 1533, ring segment; 154, tube electrode; 161, first plate; 162, second plate; 163, third plate.

detailed description

Typical embodiments that embody the features and advantages of the present invention will be described in detail in the following description. It should be understood that the present invention is capable of various changes in different embodiments without departing from the scope of the present invention, and that the description and illustrations therein are illustrative in nature and not limiting. this invention.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation indicated by rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc. The positional relationship is based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the application and simplifying the description, and does not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as limiting the application.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of said features. In the description of the present application, "plurality" means two or more, unless otherwise specifically defined.

In the description of this application, it should be noted that unless otherwise specified and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. Connected, or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in this application in specific situations.

It should be noted that, in the case of no conflict, the features in the embodiments of the present invention may be combined with each other.

Definition Interpretation:

Left atrial appendage entrance: The location where the left atrial appendage enters from the left atrium.

Proximal end and distal end: After a component is implanted, the end relatively close to the outside of the body is the proximal end of the component; after a certain component is implanted, the end relatively close to the body is the distal end of the component. In other words, after the LAA occlusion ablation device is implanted in the left atrial appendage, the proximal end of a certain component in the LAA occlusion ablation device is the end of the component close to the left atrium, and the distal end of a certain component is the end of the component close to the left atrial appendage .

Insulation treatment: Forming an insulating layer on the surface of a component to insulate that part of the component. Specifically, the insulation treatment methods include: coating insulation coating materials at the position where insulation treatment is required, coating materials include but not limited to parylene coating, PTFE coating, PI coating; or, where insulation treatment is required The treated position is covered with an insulating film, and the film material includes but not limited to FEP, PU, ETFE, PFA, PTFE, PEEK, silica gel; or, an insulating sleeve is worn at the position that needs to be insulated, and the material of the insulating sleeve includes but not Limited to FEP, PU, ETFE, PFA, PTFE, PEEK, Silicone.

The left atrial appendage occlusion ablation device provided by the embodiment of the present invention is used to be implanted in the ostium of the left atrial appendage, and can perform pulse ablation or radiofrequency ablation on the left atrial appendage tissue. Pulse ablation uses a high-intensity pulsed electric field to cause irreversible electrical breakdown of the cell membrane, which is called irreversible electroporation (IRE) in the medical field, and causes cell apoptosis to achieve non-thermal ablation of cells, so it is not affected by the heat sink effect. The high-voltage pulse sequence produces less heat and does not need saline irrigation for cooling, which can effectively reduce the occurrence of gas explosion, eschar and thrombus. The pulse ablation treatment time is short, the treatment time of applying a set of pulse sequences is less than 1 minute, and the whole ablation time is generally no more than 5 minutes. Moreover, since different tissues have different response thresholds to pulsed electric fields, it is possible to ablate the myocardium without disturbing other adjacent tissues, thereby avoiding accidentally injuring tissues adjacent to the left atrial appendage. In addition, compared with other energies, pulse ablation does not require heat conduction to ablate deep tissues, and all cardiomyocytes distributed above a certain electric field strength will undergo electroporation, which reduces the pressure requirements for catheter abutment during ablation. Therefore, even if the ablation instrument does not completely adhere to the inner wall of the left atrial appendage after entering the left atrial appendage, the ablation effect of the IRE will not be affected. Electrodes that release pulse energy can also collect intracardiac electrical signals. Before ablation, the collected intracardiac electrical signals are transmitted to the ECG synchronization instrument, so that the pulse output is synchronized in the absolute refractory period of myocardial contraction, so as not to interfere with the heart rate and reduce bursts. Cardiac arrhythmias; complete electrical isolation of tissue can also be judged by intracardiac signals after ablation procedures.

Example 1

Fig. 1 is a schematic structural view of the left atrial appendage occlusion ablation device provided in this embodiment, and Fig. 2 is a schematic cross-sectional structure diagram of the left atrial appendage occlusion ablation device provided in this embodiment, and Fig. 2 removes the flow blocking film 126 compared with Fig. 1 , and part of the first skeleton 111 of the anchoring disc 110 in FIG.

Please refer to FIG. 1 and FIG. 2 . The left atrial appendage occlusion ablation device provided in this embodiment includes an ablation stent 100 , and the ablation stent 100 includes an anchoring disc 110 , a sealing disc 120 and an insulating connector 130 .

Both the first frame 111 of the anchoring disc 110 and the second frame 121 of the sealing disc 120 are radially stretchable support structures. For example, the stent structure may be a grid-like or mesh-like stent. Under the pressure of external force, the stent structure can be shrunk at the axial center in the radial direction, so as to facilitate the preservation or delivery of the ablation stent 100 as a whole. When the compressive force disappears, it can expand naturally in the radial direction to restore the grid-like or mesh-like stent structure, so that the ablation stent 100 can be fixed on the left atrial appendage as a whole. It can be understood that the stent structure may also be a radially expandable stent structure of other shapes.

Generally, both the first skeleton 111 and the second skeleton 121 are made of metal materials with shape memory and superelasticity, such as nickel-titanium alloy. Specifically, it can be made by weaving metal wires or cutting metal pipes.

In this embodiment, the sealing disc 120 as a whole is used as a conductive part for transmitting ablation energy for circular ablation, or for collecting tissue physiological signals for mapping. When the anchoring disc 110 is anchored in the left atrial appendage, the sealing disc 120 can completely block the entrance of the left atrial appendage, block the thrombus inside the left atrial appendage, and effectively prevent the thrombus from entering the left atrium. At the same time, the sealing disc 120 can also well ablate the inner wall tissue of the inlet of the left atrial appendage, and has a good ablation effect. Specifically, the tissue at the mouth of the left atrial appendage is more regular than the internal tissue of the left atrial appendage, and the surface is smooth. Ablation of the mouth of the left atrial appendage is more conducive to the formation of a complete ablation zone at the mouth of the left atrial appendage. Electrically isolated from the left atrium.

In some embodiments, the anchoring disc 110 is provided with a second conductive part 114, and the sealing disc 120 as a whole serves as a first conductive part 122, and the second conductive part 114 and the first conductive part 122 are used to respectively transmit ablation energy to the tissue, or for mapping. The second conductive part 114 and the first conductive part 122 can be used to transmit electrical ablation energy with different polarities. The second conductive part 114 and the first conductive part 122 can form an ablation electric field to improve the ablation effect.

In some embodiments, for example, in the embodiment where the second conductive part 114 and the first conductive part 122 are used to transmit radiofrequency energy, the second conductive part 114 and the first conductive part 122 can be used to transmit ablation energy with the same polarity, Or deliver the same ablation energy.

In some implementations, the second conductive part 114 and the first conductive part 122 can also be used for mapping, that is, for collecting electrophysiological signals of the target tissue. Or in some embodiments, it has both the functions of ablation and mapping, for example, part of the second conductive part 114 and/or the first conductive part 122 is used for mapping, and part of it is used for ablation, or the second conductive part 114 And/or the first conductive part 122 is used for mapping and ablation in time.

It should be noted that, in some other embodiments, the first frame 111 can also serve as the second conductive part 114 as a whole; or, the second conductive part 114 can also be an electrode part arranged on the peripheral wall of the first frame 111, and The second conductive part 114 can be fixedly connected to the inner wall or the outer peripheral wall of the first frame 111 , and can also be detachably or movably connected to the first frame 111 .

Still referring to FIG. 1 and FIG. 2, both ends of the insulating connector 130 are respectively connected to the anchoring disc 110 and the sealing disc 120, specifically, the distal end of the insulating connector 130 is connected to the anchoring disc 110, and the proximal end is connected to the sealing disc 120. , the second conductive part 114 on the first frame 111 is electrically isolated from the first conductive part 122 on the second frame 121 through the insulating connector 130 .

It should be noted that, in some other embodiments, the insulating connector 130 can also be omitted, and the part of the first frame 111 itself except the second conductive part 114 can be used for insulation, so that the second conductive part 114 and the first The conductive portion 122 is electrically isolated.

During use, different electrical ablation energies are transmitted to the second conductive part 114 and the first conductive part 122 respectively, for example, the second conductive part 114 is electrically connected to the positive output terminal of the external signal source, and the first conductive part 122 is connected to the external signal source. The negative electrode of the output terminal of the signal source is electrically connected, and the ablation is realized through the electric field formed between the second conductive part 114 and the first conductive part 122 , and the ablation effect is good.

In addition, the insulation performance between the second conductive part 114 and the first conductive part 122 is improved by the insulating connector 130, the possibility of realizing an electrical connection between the second conductive part 114 and the first conductive part 122 is reduced, and the Ablation success rate and device reliability.

It can be understood that, in some other embodiments, electrical signals with all the same parameters can also be transmitted to the second conductive part 114 and the first conductive part 122 according to requirements.

The left atrial appendage occlusion ablation device provided in this embodiment is further described below:

FIG. 3 is an enlarged schematic diagram of a local structure at III in FIG. 2 , and FIG. 4 is a schematic structural diagram of the conveyor 140 provided in this embodiment.

Please refer to FIG. 1 to FIG. 4 , the left atrial appendage occlusion ablation device provided in this embodiment further includes a transporter 140, the ablation support 100 is used to be loaded on the distal end of the transporter 140, and the transporter 140 is used to deliver and release the ablation The stent 100 is moved to the target position, namely the entrance of the left atrial appendage. It can be understood that, in some embodiments, the left atrial appendage occluder ablation device provided in the present application can also be applied to treat other tissue defects.

The conveyor 140 includes an outer tube 143 , a first conduit 142 , a second conduit 141 , and a handle 144 sheathed in each other.

The outer tube 143 is tubular, and the distal end of the outer tube 143 can accommodate the anchoring disc 110 and the sealing disc 120 in a radially contracted state.

The first conduit 142 is tubular, and is movably passed through the outer tube 143 . The first conduit 142 can move axially relative to the outer tube 143 . The distal end of the first conduit 142 is detachably connected to the sealing disk 120 and electrically connected to the sealing disk 120 . The proximal end of the first conduit 142 is electrically connected to an external signal source, so that the external signal source can transmit ablation energy to the sealing disc 120 through the first conduit 142 . Moreover, the first catheter 142 can drive the sealing disc 120 and the anchoring disc 110 to move axially in the outer tube 143, so that the entire ablation stent 100 is released from the distal end of the outer tube 143, or retracted and accommodated in the outer tube 143 .

The second conduit 141 is tubular and is movably passed through the first conduit 142 . The second conduit 141 can move axially relative to the first conduit 142 . The distal end of the second catheter 141 can be detachably connected to the anchoring disc 110 and electrically connected to the second conductive part 114 , so as to transmit electric ablation energy to the second conductive part 114 through the second catheter 141 . It can be understood that, the second conduit 141 may not be connected with the anchor plate 110 , but directly detachably electrically connected with the second conductive part 114 .

Specifically, the first conduit 142 and the second conduit 141 are used to connect different output terminals of the external signal source, for example, one of the first conduit 142 and the second conduit 141 is used to connect the positive pole of the output terminal of the external signal source, and the other is used for Connect to the negative terminal of the output terminal of the external signal source.

It should be noted that the first conduit 142 and the second conduit 141 can also be used to transmit the collected tissue physiological signals for mapping.

A handle 144 is provided at the proximal end of the outer tube 143 . When the ablation stent 100 is implanted, the first catheter 142 controls the ablation stent 100 to be accommodated at the distal end of the outer tube 143 . When the distal end of the outer tube 143 is inserted into the left atrial appendage, and the distal end of the outer tube 143 stays at the left atrial appendage, the handle 144 is used to manipulate the outer tube 143 to retreat, so that the ablation stent 100 can be released.

Moreover, the second catheter 141 is arranged as a tubular structure, so that the inner hole of the second catheter 141 can be used for guiding the traction wire to pass through, thereby facilitating the integration of the outer tube 143, the first catheter 142, the second catheter 141 and the ablation stent 100 Move along the pulling wire and deliver to the target position.

Referring to FIG. 3 , the insulating connector 130 is provided with a first conductive connecting portion 134 . The first conductive connection part 134 is used to detachably connect with the second conduit 141 in the conveyor 140, and the second conduit 141 is electrically connected to the second conductive part 114 through the first conductive connection part 134, thereby passing through the second conduit 141 The ablation energy is delivered to the second conductive part 114 , and after the ablation is completed, the second catheter 141 can be released from the first conductive connection part 134 .

In some embodiments, the insulating connector 130 is cylindrical, and the first conductive connecting portion 134 is disposed on an inner surface of the insulating connector 130 . Optionally, the first conductive connection part 134 is threadedly connected to the second conduit 141 to realize a detachable connection between the first conductive connection part 134 and the second conduit 141 . It can be understood that, in some other embodiments, the detachable connection between the first conductive connection part 134 and the second conduit 141 can be implemented in other ways according to requirements, such as magnetic connection or clamping.

The insulating connector 130 extends axially, its proximal end is connected to the sealing disc 120 , and its distal end is connected to the anchoring disc 110 . An insulating axial section is provided in the insulating connector 130 , that is, to realize the insulating connection between the sealing disc 120 and the anchoring disc 110 , thereby improving the insulation performance between the two discs. "Axial section" refers to a section that extends along the axial direction of the component and circles around the axial direction. The component extends along its axial direction. The surface of the connector 130. In this embodiment, the ablation stent 100 is symmetrical along the axis, and the axis of the insulating connector 130 is the axis of the ablation stent 100 .

The insulating connecting piece 130 includes a first connecting piece 131 and a second connecting piece 132 connected in sequence, that is, the first connecting piece 131 and the second connecting piece 132 are connected in sequence along the axial direction. The first connecting piece 131 is connected to the anchoring plate 110 , that is, the anchoring plate 110 is constricted and connected to the first connecting piece 131 . The second connecting piece 132 is connected to the sealing disk 120 , and the sealing disk 120 is convergingly connected to the second connecting piece 132 .

Further, as shown in FIG. 3, in this embodiment, the insulating connector 130 further includes a third connector 133, and the third connector 133 is arranged between the first connector 131 and the second connector 132, so that The first connection part 131 is indirectly connected to the second connection part 132 . A distal end of the third connecting member 133 is connected to a proximal end of the first connecting member 131 , and a proximal end of the third connecting member 133 is connected to a distal end of the second connecting member 132 .

The third connecting piece 133 can also be provided in multiples, and they are connected successively in the axial direction, wherein the third connecting piece 133 at the farthest end is connected with the first connecting piece 131, and the third connecting piece 133 at the most end is connected with the second connecting piece 131. 132 connected. That is, in the ablation stent 100 shown in this embodiment, the first connecting piece 131 is connected to the second connecting piece 132 through one or more third connecting pieces 133, thereby extending the length of the insulating connecting piece 130, realizing the anchoring plate 110 and the second connecting piece 132. Indirect connection of sealing disk 120 .

In this embodiment, the anchor plate 110 is connected to the first connecting part 131, the first connecting part 131 includes a first conductive connecting part 134, and the first conductive connecting part 134 is insulated from the second connecting part 132, so as to realize the second connecting part 134. Electrical isolation between the second conductive portion 114 and the first conductive portion 122 . The distal end of the sealing disc 120 is connected with the second connecting member 132 . At the same time, the second connecting piece 132 is cylindrical and forms a channel through which the second conduit 141 passes, so that the second conduit 141 passes through the channel of the second connecting piece 132 and is connected to the first conductive connecting portion 134 . In some embodiments, the second connecting member 132 is used to be fixedly connected to the distal end of the sealing disk 120 to bundle the multiple nickel-titanium alloy wires in the sealing disk 120 .

Specifically, at least part of the axial section of the first connecting member 131 can be insulated, so as to realize the insulating connection between the first conductive connecting portion 134 and the first conductive portion 122 . In some embodiments, the proximal end of the at least part of the axial section extends beyond the proximal end of the first conductive connection part 134, that is, the proximal end of the first conductive connection part 134, compared to the proximal end of the at least part of the axial section The proximal end is further from the sealing disc 120 .

For example, the first connector 131 is set to at least the proximal end is insulated, and the first conductive connection portion 134 is set to the thread of the inner wall of the first connector 131 far end, in this case, the second connector 132 and the third connector The conductive and insulating properties of 133 are not limited. The proximal end of the insulating axial section is closer to the proximal end of the first connecting member 131 than to the proximal end of the first conductive connecting portion 134 . The insulating axial section may be provided on the insulating surface of the first connecting member 131, or the material of the first connecting member 131 in the axial section is insulated, and the insulating axial section The remote location is not limited.

In some embodiments, in the axial direction, the distal end of the insulating axial section is closer to the sealing disk 120 than the proximal end of the first conductive connection part 134 , or, the distal end of the insulating axial section The proximal end relative to the first conductive connection part 134 is closer to the anchoring disc 110 , or the insulated axial section extends over the first connection part 131 .

In some embodiments, the second connecting member 132 can also be set to insulate at least part of the surface of the axial section, so as to realize the insulating connection between the first conductive connecting part 134 and the first conductive part 122, for example, the second connecting member 132 It is set that one end is made of insulating material and the other end is made of conductive material. At this time, the conductive performance of the part of the first connecting member 131 except the first conductive connecting part 134 is not limited, and the whole can be made of conductive material. The anchoring part 113 is bundled in the first connecting part 131; or in the first connecting part 131, at least part of the axial section surface at the proximal end of the first conductive connecting part 134 is insulated, and the second connecting part 132 is set to at least Part of the axial section is surface insulated.

It can be understood that, in some other embodiments, any one of the third connecting parts 133 may also be configured to insulate at least part of the surface of the axial section, so as to realize the connection between the first connecting part 131 and the second connecting part 132. The insulating connection between the first conductive connection part 134 and the first conductive part 122 is further realized.

Specifically, the first connecting member 131 can be configured such that at least part of the axial section of the first connecting member 131 at the proximal end of the first conductive connecting part 134 is insulated from the surface, so as to realize the insulation of the first conductive connecting part 134 and the third connecting member 133 Correspondingly, the second connecting member 132 can also be set to insulate at least part of the surface of the axial section, or at least part of the surface of the axial section of at least one third connecting member 133; even the two of the above methods, The simultaneous arrangement of the three can realize the insulation between the first conductive connection part 134 and the sealing disk 120 , and further realize the electrical isolation between the first conductive connection part 134 and the first conductive part 122 .

According to requirements, the structure of the insulating connector 130 can be set as a structure in which the first connecting member 131, the second connecting member 132 and the third connecting member 133 are integrated in FIG. structure, the distal end of the sealing disk 120 is bundled at the proximal end of the cylindrical structure, the anchoring disk 110 is bundled at the distal end of the cylindrical structure, and the first conductive connection part 134 is a conductive material disposed on its inner surface made internal thread. In this embodiment, the first connector 131 is made of conductive material to realize the electrical connection between the second conduit 141 and the second conductive part 114, and the second conduit 141 is connected to the first skeleton of the anchoring plate 110 through the first conductive connection part 134. 111 is electrically connected. The third connecting piece 133 is made of insulating material, so as to realize the insulating connection between the second connecting piece 132 and the first connecting piece 131 and the first conductive connecting portion 134, so that the second connecting piece 132 can be set as an overall insulation or Conductive overall.

In this embodiment, a lumen for the second conduit 141 to pass through is formed on the insulating connector 130, and the lumen extends to the first conductive connection portion 134, so that the second conduit 141 penetrated in the lumen can be connected to the first conductive connection portion 134. A conductive connecting portion 134 is electrically connected. Specifically, the insulating connector 130 in this embodiment includes a first connector 131, a third connector 133 and a second connector 132, and the first connector 131, the third connector 133 and the second connector 132 are all in the form of Cylindrical, and the first connecting piece 131, the second connecting piece 132 and the third connecting piece 133 communicate in sequence to form the cavity (the position of the arrow in Figure 3 is the cavity, and the direction of the arrow indicates that the second conduit 141 The direction of penetration in the lumen).

The two parts connected to each other in the insulating connector 130 are detachably connected, that is, in this embodiment, the first connector 131 is detachably connected to the third connector 133, and the second connector 132 is connected to the third connector. The member 133 is detachably connected. Optionally, the first connecting piece 131 is screwed to the third connecting piece 133 , and the second connecting piece 132 is screwed to the third connecting piece 133 . Specifically, the first connecting piece 131 is provided with a first threaded portion, and the distal end of the third connecting piece 133 is provided with a second threaded portion, and the first threaded portion and the second threaded portion are screwed together, thereby realizing the first connecting piece 131 and the second threaded portion. The detachable connection of the third connecting piece 133 . The second connecting piece 132 is screwed to the third connecting piece 133 . Specifically, the proximal end of the third connecting part 133 is provided with a third threaded part, the second connecting part 132 is provided with a fourth threaded part, and the third threaded part is threadedly engaged with the fourth threaded part.

Specifically, the third connecting piece 133 includes a large pipe section 1331 and a small pipe section 1332 arranged in the axial direction, and the outer diameter of the large pipe section 1331 is larger than the outer diameter of the small pipe section 1332 . The first threaded part is an internal thread provided on the inner wall of the proximal end of the first connecting member 131 , and the second threaded part is an external thread provided on the outer wall of the small tube section 1332 . The third threaded part is an internal thread provided on the inner wall of the large pipe section 1331 , and the fourth threaded part is an external thread provided on the outer wall of the second connecting piece 132 . It can be understood that, in some other embodiments, the third connecting member 133 may also be configured as a single-section tubular shape with both ends equal in diameter.

Further, a first installation space 1311 is provided on the first connecting member 131 , and one end of the anchor plate 110 protrudes into the first installation space 1311 , so as to be contained in the first installation space 1311 . Specifically, the first connecting member 131 is provided with two ring-shaped projections nested in each other, and a receiving groove is formed between the two ring-shaped projections, and the space in the receiving groove is used as the first installation space 1311. And the first installation space 1311 is ring-shaped. The accommodating groove has an opening towards the distal end, and one end of the anchoring plate 110 protrudes into the first installation space 1311 through the opening. It can be understood that, in some other embodiments, the first connecting member 131 can also be configured to include inner and outer sleeves nested in each other, and the annular area formed between the inner and outer sleeves can be used as the first installation Space 1311, at this time, one of the inner sleeve and the outer sleeve can be connected with the second connecting piece 132 .

Further, a second installation space 1323 is formed on the second connecting member 132 , and the distal end of the sealing disc 120 is converged in the second installation space 1323 . Specifically, the second connecting member 132 includes an inner sleeve 1321 and an outer sleeve 1322 nested with each other, and a second installation space 1323 is formed between the inner sleeve 1321 and the outer sleeve 1322, and the second installation space 1323 is annular. One of the inner sleeve 1321 and the outer sleeve 1322 is connected to the third connecting member 133 . In this embodiment, the fourth threaded portion is disposed on the outer peripheral wall of the outer sleeve 1322 , that is, the outer sleeve 1322 in the second connecting member 132 is connected to the third connecting member 133 . It can be understood that, in some other embodiments, the second connecting member 132 can also be provided as an integral structure, and a receiving groove is opened on it, and the space in the receiving groove is the second installation space 1323 .

Please refer to FIG. 1 and FIG. 2 , in this embodiment, the sealing disk 120 includes the proximal portion of the ablation stent 100 , the anchoring disk 110 includes the distal portion of the ablation stent 100 , and the second conductive part 114 is part of the anchoring disk 110 , the first conductive portion 122 is all the sealing disc 120 . That is, the second conductive part 114 is at least a part of the anchoring disk 110 , and the first conductive part 122 is the whole of the sealing disk 120 . It can be understood that the second conductive portion 114 may also be the entirety of the anchor plate 110 .

Further, in the ablation stent 100 , the area corresponding to the second conductive portion 114 and the first conductive portion 122 is used as an active area, and the area of the ablation stent 100 other than the active area is an insulating area. It can be understood that, in some embodiments, at least part of the ablation stent 100 in the insulating region can also be made of an insulating material, for example, at least part of the ablation stent in the insulating region is made of an insulating degradable material 100.

Specifically, in this embodiment, the first skeleton 111 and the second skeleton 121 are connected through an insulating connecting piece 130. In this embodiment, the first connecting piece 131 is used to constrict the first skeleton in the anchoring plate 110. 111 , the second connecting piece 132 is used to constrict the distal end of the second skeleton 121 in the sealing disc 120 .

In this embodiment, the first frame 111 is made of metal as a whole, and part of its surface is used as the second conductive part 114, that is, the part of the first frame 111 used as the second conductive part 114 is not insulated, and the surface of the rest is insulated. treatment, so as to insulate the surface of this part, and avoid the problem that the conductive area of the second conductive part 114 is too large, which affects the ablation effect. Since the first frame 111 is made of metal, the first connecting member 131 conducts electricity as a whole, and the second conductive portion 114 and the first conductive connection portion 134 can directly realize electrical conduction through the first frame 111 .

It can be understood that, in some other embodiments, only a part of the first frame 111 can be made of metal material, and the rest can be made of insulating material, so as to insulate the surface of this part. A conductive connecting portion 134 is electrically connected to the second conductive portion 114 .

Furthermore, the part of the first skeleton 111 that is used to abut against the inner wall tissue of the left atrial appendage is used as the second conductive part 114, and the second conductive part 114 is in the shape of a ring, so that the corresponding ablation zone formed by the second conductive part 114 is in the shape of a ring. Help to improve the effect of left atrial appendage ablation. The outer periphery of the second conductive part 114 is covered with a flow-blocking film 126, and the flow-blocking film 126 has pores, so that the flow-blocking film 126 can at least filter the thrombus, that is, prevent the thrombus in the left atrial appendage from entering the left atrium, and also ensure that the second conductive part 114 Capable of delivering ablative energy to tissue.

It should be noted that, in this embodiment, part of the first skeleton 111 is used as the second conductive part 114, and the rest of the surface is insulated. It can be understood that in some other embodiments, the entire first skeleton 111 can also At the same time, it serves as the second conductive part 114 for releasing ablation energy to the tissue.

Please refer to FIG. 1 and FIG. 2 , for the sealing disk 120 , the second frame 121 is made of metal as a whole, and the second frame 121 as a whole serves as the first conductive portion 122 . Since the second frame 121 is made of metal, the first conductive part 122 can directly realize electrical conduction through the second frame 121 without additional wires.

It should be noted that, in this embodiment, the part of the second skeleton 121 that needs surface insulation is realized through insulation treatment. In this embodiment, the sealing disc 120 is set to further include an insulating film 125, and the insulating film 125 is coated on the outer peripheral wall of the distal end of the second framework 121, and the insulating film 125 can block the connection between the distal end of the second framework 121 and the first Between the proximal ends of the skeletons 111 , the insulating film 125 is used to isolate the first skeleton 111 and the second skeleton 121 , preventing the expanded first skeleton 111 and the second skeleton 121 from directly contacting each other.

In this embodiment, the second skeleton 121 is a double-layer mesh disk made of wire weaving, which includes a proximal skeleton and a distal skeleton, the proximal skeleton is located on one side of the proximal end of the distal skeleton, and the proximal The frame is peripherally connected to the distal frame. Optionally, the axial projection of the outer shape of the sealing disk 120 is trapezoidal, so as to match the anatomical structure of the inlet of the left atrial appendage, and the inlet of the left atrial appendage is sealed by the sealing disk 120 .

It should be noted that, in this embodiment, the second frame 121 is braided with metal wires. It can be understood that in some other embodiments, the second frame 121 can also be made in other ways according to requirements, for example Manufactured by pipe cutting.

Please refer to FIGS. 1 to 4 in combination. In this embodiment, the sealing disc 120 further includes a second conductive connection portion 124, and the proximal end of the second skeleton 121 is connected to the second conductive connection portion 124. Specifically, the second skeleton 121 The proximal end converges at the second conductive connection part 124 . The second conductive connecting portion 124 is used for detachably connecting with the first conduit 142 , and the external signal source is electrically connected to the first conductive portion 122 sequentially through the first conduit 142 and the second conductive connecting portion 124 . The second conductive connection part 124 can also be used to transmit tissue physiological signals collected by the sealing disc 120 .

Specifically, the second conductive connecting portion 124 is an annular cylindrical structure, in which a through hole extending along the axial direction is formed, and the through hole can allow the second conduit 141 to pass through. The first catheter 142 is detachably connected to the second conductive connection part 124, so that when the ablation stent 100 is released at the left atrial appendage under the action of the conveyor 140, the implantation of the ablation stent 100 is completed, and the ablation can be performed. A catheter 142 is released from the second conductive connection part 124, so that the ablation stent 100 is left at the left atrial appendage, and the first catheter 142 and the second catheter 141 are withdrawn from the body.

Optionally, the second conductive connection part 124 is screwed to the first conduit 142 . Specifically, the inner wall of the second conductive connecting portion 124 is provided with a sixth threaded portion, so that the detachable connection between the second conductive connecting portion 124 and the first conduit 142 is realized through the screw connection of the sixth threaded portion and the first conduit 142 . It can be understood that, in some other embodiments, the detachable connection between the second conductive connection part 124 and the first conduit 142 can also be realized by magnetic connection or clamping according to requirements.

Please refer to FIG. 1 , in this embodiment, the sealing disc 120 further includes a flow blocking film 126 disposed in the second frame 121 . Specifically, in this embodiment, the flow blocking film 126 is arranged radially inside the second framework 121 . In other embodiments, the flow blocking film 126 can also cover the outside of the second framework 121 . The blocking membrane 126 can at least be used to block the outflow of the thrombus in the left atrial appendage, and at the same time, according to the difference in the porosity of the blocking membrane 126, it can even block the blood flow in the left atrial appendage from flowing into the left ventricle. Specifically, since the second skeleton 121 of the sealing disk 120 is a mesh structure, a plurality of mesh holes are formed on it, and the mesh holes are closed by setting the flow blocking film 126, thereby preventing the thrombus at the distal end of the flow blocking film 126 from moving to the proximal end. Move to avoid thrombus, etc. in the left atrial appendage entering the left ventricle. It should be noted that when the mesh holes on the second skeleton 121 are small enough and dense enough, the flow blocking film 126 may not be provided.

The distal end of the anchoring disc 110 is provided with a blocking film 126 with a blocking effect, and the blocking film 126 is arranged at the distal end of the first skeleton 111, thereby helping to block the thrombus at the distal end of the anchoring disc 110 from moving toward the sealing disc 120. direction to move. Further, the blocking film 126 on the anchoring disk 110 is configured as a structure with holes, so that the second conductive part 114 can release ablation energy to the inner wall tissue. It should be noted that, in some embodiments, the material of the blocking film 126 and the material used for the insulation treatment can be set to be the same.

FIG. 5 is a schematic structural diagram of the first framework 111 in FIG. 2 .

Please refer to FIG. 1 and FIG. 5 in combination. In this embodiment, the first frame 111 includes a plurality of support portions 112 and a plurality of anchor portions 113 , and the plurality of anchor portions 113 are disposed around the outer circumference of the plurality of support portions 112 .

Each support portion 112 includes a support rod 1121 and a first branch 1122 and a second branch 1123 arranged at one end of the support rod 1121. The first branch 1122 and the second branch 1123 are rod-shaped, and the shape of the support portion 112 thus formed is Roughly Y-shaped.

Specifically, the support rods 1121 include opposite first ends and second ends, the first ends of the plurality of support rods 1121 are connected to the insulating connector 130, and the second ends of the plurality of support rods 1121 spread radially outward, gradually Away from the axis of the anchoring disc 110 , a horn-like shape is formed, and the first branch 1122 and the second branch 1123 are connected at the second ends of the corresponding support rods 1121 . In this embodiment, the first end is the proximal end of the support rod 1121 , and the second end is the distal end of the support rod 1121 . It can be understood that, in the modified embodiment, the first end is not limited to the proximal end of the support rod 1121 , and the second end is not limited to the distal end of the support rod 1121 .

An end of each first branch 1122 away from the support rod 1121 is connected to an end of a second branch 1123 of an adjacent support portion 112 away from the support rod 1121 , and the connection forms a first connection point 1124 . Each anchoring portion 113 is connected to the corresponding first connection point 1124 and extends toward the proximal end. The first frame 111 formed in this way has a double-layer structure, a plurality of support rods 1121 surround the inner layer of the first frame 111 , and a plurality of anchoring portions 113 surround the outer layer of the first frame 111 . In the first frame 111, the part of the anchoring portion 113 that is used to abut against the inner wall tissue of the left atrial appendage is used as the second conductive portion 114, and the second conductive portion 114 is ring-shaped, thereby forming a ring around the first frame 111 through the second conductive portion 114. Extended circular ablation zone.

Optionally, the first frame 111 further includes a connecting ring 118, and the proximal ends of the plurality of support rods 1121 are all connected to the connection ring 118, thus connecting the proximal ends of the plurality of support rods 1121 together. When the anchor plate 110 is connected to the insulating connector 130 , the connecting ring 118 is accommodated in the first installation space 1311 , so that the proximal end of the inner layer of the first frame 111 is contained in the first installation space 1311 . It can be understood that, in some other embodiments, the connecting ring 118 may not be provided, but the proximal end of the support rod 1121 is directly restrained in the first installation space 1311, so as to realize the insulation between the anchor plate 110 and the first installation space 1311. Connection of connector 130 . Optionally, the connecting ring 118, the plurality of support portions 112 and the plurality of anchor portions 113 are integrally made by cutting a pipe.

Further, the plurality of anchoring parts 113 are divided into multiple groups, each group of anchoring parts 113 includes two adjacent anchoring parts 113, and the proximal ends of the two anchoring parts 113 in each group of anchoring parts 113 are connected , forming a grid structure. Further, in each group of anchoring parts 113, the junction of the two anchoring parts 113 is bent and extended toward the axis of the first skeleton 111, that is, bent inward to form a hook shape, thereby reducing the tension of the ends of the anchoring parts 113. Irritation and damage to tissue.

Further, the anchoring plate 110 also includes a barb 117 arranged radially outside the first frame 111, the distal end of the barb 117 is connected to the anchoring part 113, and the proximal end of the barb 117 is located in the radial direction of the first frame 111. outside. Specifically, the barb 117 is connected to the anchoring part 113, and when the LAA occlusion ablation device is implanted in the LAA, the barb 117 penetrates into the LAA tissue, preventing the anchoring disc 110 from detaching from the inner wall tissue of the LAA.

According to the left atrial appendage blockage ablation device provided in this embodiment, the working principle of the left atrial appendage blockage ablation device is:

The first conductive connection part 134 of the left atrial appendage occlusion ablation device is electrically connected to the second catheter 141 , and the second conductive connection part 124 is electrically connected to the first catheter 142 . Before use, the ablation stent 100 is stored in the conveyor 140 in a compressed state. During use, the ablation stent 100 is transported and released to the mouth of the left atrial appendage in the body through the conveyor 140. At this time, the anchoring plate 110 of the ablation stent 100 is expanded. The state is anchored in the left atrial appendage, and the barb 117 of the anchoring disc 110 penetrates into the inner wall tissue of the left atrial appendage; the sealing disc 120 of the ablation stent 100 is in an expanded state and is located at the entrance of the left atrial appendage, so as to seal the entrance of the left atrial appendage through the sealing disc 120 .

After the implantation is completed, the external energy source sequentially transmits electrical ablation energy to the first conductive part 122 through the first catheter 142 and the second conductive connection part 124, and at the same time, the second catheter 141 sends electrical ablation energy to the second conductive part 114 through the first conductive connection part 134. The electrical ablation energy is transmitted, and the electrical ablation energy of the second conductive part 114 and the first conductive part 122 are different. The negative electrode of the delivery end is electrically connected; if the second conductive part 114 is electrically connected to the negative electrode, then the first conductive part 122 is electrically connected to the positive electrode. In this way, an electric field is formed between the second conductive part 114 and the first conductive part 122 to realize ablation, and the ablation effect is good. After the ablation is completed, the first conductive connection part 134 is released from the second catheter 141, and the second conductive connection part 124 is released from the first catheter 142, so that the second catheter 141 and the first catheter 142 are withdrawn from the body, and the left atrial appendage The occlusion ablation device is left in the patient.

A left atrial appendage occlusion ablation device provided in this embodiment has at least the following advantages:

The left atrial appendage occlusion ablation device provided in this embodiment is released in the left atrial appendage by using the anchoring disc 110. The anchoring disc 110 can anchor the tissue inner wall of the left atrial appendage, and is released at the entrance of the left atrial appendage by using the sealing disc 120. The disc 120 blocks the entrance of the left atrial appendage, and then fixes the entire left atrial appendage blockage ablation device at the left atrial appendage. At the same time, the sealing disc 120 conducts electricity as a whole and is used to transmit ablation energy, and ablate the tissue at the entrance of the left atrial appendage and inside the left atrial appendage, which can greatly improve the ablation effect. The sealing disc, as the first conductive part, can also be used to collect tissue physiological signals for mapping. In addition, the left atrial appendage occlusion ablation device combines ablation and occlusion, which simplifies the procedure of "ablation + left atrial appendage occlusion" one-stop treatment and helps reduce the difficulty of surgery.

Example 2

FIG. 6 is a schematic structural diagram of the insulating connector 130 in the left atrial appendage occlusion ablation device provided in this embodiment.

Please refer to FIG. 6 and in combination with FIG. 3 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the insulating connector 130 is different .

In this embodiment, the interconnected parts of the insulating connector 130 are interference-fitted, so that the interconnected parts of the insulating connector 130 are detachably connected. That is, there is an interference fit between the first connecting piece 131 and the third connecting piece 133 , and an interference fit between the third connecting piece 133 and the second connecting piece 132 . It can be understood that, in some other embodiments, the connection mode between the first connection part 131 and the third connection part 133 can also be set to be different from the connection mode between the third connection part 133 and the second connection part 132 .

Specifically, the inner peripheral wall of the proximal end of the first connecting piece 131 is in interference fit with the outer peripheral wall of the small tube section 1332 of the third connecting piece 133 . The inner peripheral wall of the large pipe section 1331 of the third connecting piece 133 is in interference fit with the outer peripheral wall of the outer sleeve 1322 of the second connecting piece 132 .

Example 3

FIG. 7 is a schematic structural diagram of the insulating connector 130 in the left atrial appendage occlusion ablation device provided in this embodiment.

Please refer to FIG. 7 and in combination with FIG. 3 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the insulating connector 130 is different .

In this embodiment, the parts connected to each other in the insulating connector 130 are clamped, so that the parts connected to each other in the insulating connector 130 are detachably connected. That is, the first connecting part 131 is engaged with the third connecting part 133 , and the third connecting part 133 is engaged with the second connecting part 132 .

Specifically, the first connecting piece 131 is provided with a locking groove, and the third connecting piece 133 is provided with a locking wedge on the outer side of the distal end. The clamping with the third connecting piece 133 makes the first connecting piece 131 and the third connecting piece 133 stop in the axial direction. The inner side of the proximal end of the third connecting piece 133 is provided with a locking groove, and the outer side of the second connecting piece 132 is provided with a locking wedge, through which the locking groove of the third connecting piece 133 and the locking wedge of the second connecting piece 132 The engagement of the third connecting piece 133 and the second connecting piece 132 is realized, so that the second connecting piece 132 and the third connecting piece 133 stop in the axial direction.

It should be noted that the specific structure of the snap connection is not limited here, and it can be understood that in some other embodiments, other structures can also be used to realize the snap connection between the interconnected parts in the insulating connector 130. Then cooperate.

Example 4

FIG. 8 is a schematic structural diagram of the insulating connector 130 in the left atrial appendage occlusion ablation device provided in this embodiment.

Please refer to FIG. 8 and in combination with FIG. 3 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the insulating connector 130 is different .

In this embodiment, the interconnected parts in the insulating connector 130 are pivotally connected, that is, the first connector 131 is pivotally connected to the third connector 133, and the third connector 133 is pivotally connected to the second connector 132, so The first connecting part 131 can rotate axially relative to the third connecting part 133 , and the second connecting part 132 can rotate axially relative to the third connecting part 133 .

Specifically, the proximal end and the distal end of the third connecting member 133 are respectively provided with pivoting slots. The proximal end of the first connecting member 131 is provided with a first pivot joint, and the pivot connection between the first connecting member 131 and the third connecting member 133 is realized through the pivot connection between the first pivot joint and the pivot groove at the far end of the third connecting member 133 . The distal end of the second connecting member 132 is provided with a second pivot joint, and the pivot connection between the third connecting member 133 and the second connecting member 132 is realized through the pivot connection between the second pivot joint and the near-end pivot groove of the third connecting member 133. catch.

It should be noted that a through hole is still provided at the axial center of the insulating connector 130 , and the through hole can allow the second conduit 141 to pass through.

Example 5

FIG. 9 is a schematic structural diagram of the insulating connector 130 in the left atrial appendage occlusion ablation device provided in this embodiment. FIG. 10 is a schematic structural view of the insulating connector 130 of the left atrial appendage occlusion ablation device in FIG. 9 when stretched and twisted.

Please refer to FIG. 9 and FIG. 10 , and in combination with FIG. 3 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the insulating connector 130 structure is different.

In this embodiment, the interconnected parts in the insulating connector 130 are flexibly connected, so that the first connector 131 and the third connector 133 are flexibly connected, and the third connector 133 and the second connector 132 are flexibly connected. connect.

Specifically, the third connector 133 is a flexible rubber structure as a whole, the proximal end of the first connector 131 is provided with a first connector, the distal end of the second connector 132 is provided with a second connector, and the third connector 133 is vulcanized. It is molded between the first connector and the second connector, and the far end of the third connector 133 covers the first connector, and the proximal end of the third connector 133 covers the second connector, so that it is connected to the first connector. The anchor disc 110 of the connecting member 131 and the sealing disc 120 connected to the second connecting member 132 can be relatively stretched and torsionally movable (as shown in FIG. 10 ).

It should be noted that a through hole is still provided at the axial center of the insulating connector 130 , and the through hole can allow the second conduit 141 to pass through.

It should also be noted that, in this embodiment, the third connecting piece 133 is directly molded on the first connecting head and the second connecting head through vulcanization, and the third connecting piece 133 is connected with the first connecting piece 131 and the second connecting piece 132 The connection is not detachable, it can be understood that in some other embodiments, other ways can also be used to realize the flexible and detachable connection between the parts according to requirements.

Example 6

FIG. 11 is a schematic structural view of the left atrial appendage blockage ablation device provided in this embodiment, and FIG. 12 is a schematic cross-sectional structure view of the left atrial appendage blockage ablation device in FIG.

Please refer to FIG. 11 and FIG. 12 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the second conductive part 114 is formed in a manner different.

In this embodiment, the second conductive portion 114 is an electrode component disposed on the first frame 111 . Specifically, the anchoring plate 110 further includes a first electrode member 116 disposed on the first skeleton 111 , so that the first electrode member 116 is used as the second conductive portion 114 . The anchoring plate 110 can be set so that only the surface of the part of the first frame 111 that is not in contact with the first electrode member 116 is insulated, or it can be set so that the entire surface of the first frame 111 is insulated, or it can be set as the whole of the first frame 111 conduct electricity.

In this embodiment, the anchor plate 110 is provided with a flow blocking film 126 , and the first electrode member 116 is located outside the flow blocking film 126 , that is, the flow blocking film 126 is disposed between the first electrode member 116 and the first frame 111 . The portion of the first frame 111 that is in contact with the first electrode member 116 can be regarded as the projected portion of the first electrode member 116 on the anchoring portion 113 . As shown in FIG. 12 , in the case where the anchoring plate 110 omits the flow blocking film 126, the part where the first skeleton 111 intersects with the first electrode member 116 is the part where the first skeleton 111 contacts the first electrode member 116, correspondingly Specifically, the portion of the first skeleton 111 that does not intersect with the first electrode member 116 is the portion of the first skeleton 111 that is not in contact with the first electrode member 116 .

The second conductive part 114 bends and extends along the circumferential direction of the left atrial appendage ablation device. In this embodiment, the first pole piece 116 is bent and extended along the circumferential direction of the first frame 111, so that the first pole piece 116 arranged on the outer periphery of the first frame 111 extends in a certain range in the axial direction of the first frame 111, and then The ablation area formed by the first electrode member 116 extends along the axial direction of the first frame 111 to form a strip shape.

Specifically, the first electrode member 116 is a zigzag structure formed by bending a conductive wire. It can be understood that, in some other embodiments, the first electrode member 116 may also be configured in other shapes that are bent and extended, such as a wave shape.

Optionally, the first electrode member 116 is an electrode wire, or a strip-shaped electrode sheet. It can be understood that the type of the first electrode member 116 can also be selected according to requirements, for example, it is set as a rod-shaped electrode, an array ring electrode or Loop ablation catheter, etc. Optionally, the first electrode piece 116 extends to the first conductive connection portion 134 and is connected to the first conductive connection portion 134 by welding to realize the electrical connection between the first electrode piece 116 and the first conductive connection portion 134 .

In this embodiment, the first electrode member 116 is electrically connected to the first skeleton 111 in the active area, and pores can be provided in the flow blocking film 126 between the two to ensure electrical conduction between the two. In one embodiment, the surface of the first connecting member 131 is insulated, and/or when the surface of the first skeleton 111 is insulated, the first electrode member 116 extends to the first conductive connection part 134, or is connected to the first conductive connection part 134 through a wire. The connection part 134 is used to transmit ablation energy.

It should be noted that the insulating connector 130 in the left atrial appendage occlusion ablation device provided in this embodiment is the structure of the insulating connector 130 provided in Embodiment 1. It can be understood that it can also adopt Embodiment 2-Embodiment 6 The structure of the insulating connector 130 is provided.

Example 7

Fig. 13 is a schematic structural diagram of the left atrial appendage occlusion ablation device provided in this embodiment.

Please refer to FIG. 13 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the insulating connector 130 is different.

In this embodiment, the first conductive connecting portion 134 is detachably disposed on the first connecting member 131 . The first conductive connecting portion 134 is cylindrical and has a through hole extending axially therein. The first conductive connection part 134 is made of conductive material as a whole, and the first conductive connection part 134 is used for conductive connection with the second conductive part 114 on the first frame 111 .

In some embodiments, the first connecting part 131 and the third connecting part 133 are made of insulating material, and the second connecting part 132 may not be limited, so as to achieve electrical isolation between the first conductive connecting part 134 and the sealing disk 120 . Since the first connecting part 131 and the third connecting part 133 are integrally insulated, the insulation distance between the first conductive connecting part 134 and the sealing disc 120 can be increased, thereby improving the connection between the second conductive part 114 on the anchoring disc 110 and the sealing disc 120. The insulation distance and insulation performance between the sealing disks 120.

It should be noted that, the second conduit 141 can be connected to the first conductive connection part 134 and electrically connected, and then electrically connected to the second conductive part 114 , or electrically connected to the first electrode member 116 through the first conductive connection part 134 .

In some other embodiments, the first connecting member 131 and the second connecting member 132 are made of conductive material as a whole, and the third connecting member 133 is insulated at least on the surface, so as to realize the insulated connection between the first connecting member 131 and the second connecting member 132, and further Electrical isolation of the first conductive connection portion 134 from the sealing disc 120 is achieved. In this embodiment, the third connecting member 133 is made of insulating material as a whole. It can be understood that the insulating connection between the second connecting member 132 and the first conductive connecting portion 134 can also be realized in other ways.

Example 8

Fig. 14 shows a schematic structural diagram of the left atrial appendage occlusion ablation device provided in this embodiment. For the sake of clarity, the membrane structures such as the flow blocking membrane 126 and the insulating membrane 125 of the left atrial appendage occlusion ablation device are omitted in FIG. 14 .

Please refer to FIG. 14 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the insulating connector 130 is different. The insulating connector 130 provided in this embodiment is applicable to an embodiment in which the first electrode member 116 is used as the second conductive portion 114 , or an embodiment in which the first electrode member 116 is used as a third conductive portion independent of the second conductive portion 114 .

In this embodiment, the insulating connection part 130 further includes a fourth connection part 135 disposed between the first connection part 131 and the first conductive connection part 134 . The fourth connecting member 135 is detachably disposed on the first connecting member 131 . The first conductive connecting portion 134 is detachably disposed on the fourth connecting member 135 . That is, the fourth connecting piece 135 is sandwiched between the first connecting piece 131 and the first conductive connecting portion 134 .

Wherein, the first connecting piece 131 is used for constricting the first skeleton 111, and the second connecting piece 132 is used for constricting the second skeleton 121. The first connecting piece 131 and the second connecting piece 132 are made of conductive metal materials, which can The converging skeleton is relatively strong, which is beneficial to improving the mechanical properties of the sealing disc 120 and the anchoring disc 110 .

The third connecting piece 133 is integrally insulated and used for electrically isolating the sealing disc 120 from the anchoring disc 110 .

The first conductive connection part 134 conducts electricity as a whole, and is used to realize electrical connection with the first electrode part 116 provided on the periphery of the anchor plate 110. The first electrode part 116 directly extends to the first conductive connection part 134, or is connected by an additional wire. to the first conductive connection portion 134 .

The fourth connecting piece 135 is integrally insulated, and is used to electrically isolate the first connecting piece 131 at both ends from the first conductive connecting portion 134, so that the first skeleton 111 in the anchoring plate 110 is connected to the first conductive connecting portion 134 and the first electrode Element 116 is electrically isolated.

Please refer to FIG. 14 in conjunction with FIG. 4 , in some embodiments, only the first electrode member 116 is conductive, and the first frame 111 can be insulated. At this time, the first electrode member 116 serves as the second conductive portion 114 for ablation. The second conduit 141 may be directly connected to the first conductive connection part 134 and electrically connected, and then electrically connected to the first electrode member 116 through the first conductive connection part 134 . Since the first electrode member 116 is arranged on the outer periphery or the distal end of the first skeleton 111, the distance between the second conductive part 114 and the sealing disk 120 can be increased, that is, the distance between the conductive part on the anchoring disk 110 and the sealing disk 120 can be increased. The distance between the first conductive part 122 and the second conductive part 114 is further improved.

Still referring to FIG. 14 , in conjunction with FIG. 4 , in some other embodiments, when both the first electrode member 116 and the first skeleton 111 are conductive, the whole or part of the first skeleton 111 serves as the second conductive part 114 , The first electrode member 116 serves as the third conductive part and can be electrically isolated from the second conductive part 114 .

At this time, the first connecting part 131 , the second connecting part 132 and the first conductive connecting part 134 are integrally conductive, and the third connecting part 133 and the fourth connecting part 135 are integrally insulated. The third connection part 133 electrically isolates the first connection part 131 from the second connection part 132 , and the fourth connection part 135 electrically isolates the first connection part 131 from the first conductive connection part 134 . Meanwhile, the conveyor 140 also includes a third conduit passing through the second conduit 141 . The third conduit is movably passed through the second conduit 141 and can move relative to the second conduit 141 along the axial direction. The first catheter 142 is connected to the second conductive connection part 124 and electrically connected, so as to provide ablation energy for the first conductive part 122 . The second catheter 141 is connected to the first connecting member 131 and electrically connected, so as to provide ablation energy for the second conductive part 114 . The third conduit is connected to the first conductive connection part 134 and is conductively connected to provide ablation energy for the first electrode member 116 (ie, the third conductive part).

The second conductive part 114 , the first conductive part 122 and the third conductive part can be electrically isolated from each other, so as to realize ablation at the same time, and the ablation effect is good. In some embodiments, in the direction from the proximal end to the distal end, the first conductive part 122, the second conductive part 114 and the third conductive part can be alternately connected to the positive and negative signal source output ends in turn, and then the first conductive part Two electric fields are formed between 122 and the second conductive part 114 and between the second conductive part 114 and the third conductive part to realize ablation, thereby improving the ablation effect.

In some other embodiments, the second conductive part 114 , the first conductive part 122 and the third conductive part may also transmit electrical ablation signals with the same polarity.

Example 9

FIG. 15 is a schematic structural view of the left atrial appendage blockage ablation device provided in this embodiment, and FIG. 16 is a structural schematic view of the left atrial appendage blockage ablation device in FIG.

Please refer to FIG. 15 and FIG. 16 , this embodiment also provides a left atrial appendage occlusion ablation device, which is mainly different from the left atrial appendage occlusion ablation device provided in Embodiment 1 in the structure of the anchoring disc 110 .

In this embodiment, the first frame 111 of the anchoring plate 110 is made of braided metal wires, and the distal ends of the first frame 111 are radially inwardly constricted and connected together, so that the first frame 111 is in a cage shape. . Specifically, the anchoring disc 110 also includes a distal connecting piece 119, the distal connecting member 119 is arranged at the distal end of the anchoring disc 110, and the distal end of the wire braided to form the first skeleton 111 is converged radially inward at the distal end. The end connecting piece 119 is located, and the distal connecting piece 119 is located inside the cage surrounded by the metal wire.

Meanwhile, in the left atrial appendage blockage ablation device shown in this embodiment, the first electrode member 116 is provided on the anchor plate 110 , and the first electrode member 116 is used as the second conductive part 114 to transmit ablation energy. In some other embodiments, part or all of the first skeleton 111 may also be used as the second conductive portion 114 , and the first electrode member 116 may be used as a third conductive portion electrically isolated from the second conductive portion 114 .

Example 10

FIG. 17 is a schematic structural view of the left atrial appendage blockage ablation device provided in this embodiment, and FIG. 18 is a structural schematic view of the left atrial appendage blockage ablation device in FIG.

Please refer to FIG. 17 and FIG. 18 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the anchor disc 110 and the sealing disc 120 The structure is different.

In this embodiment, the first skeleton 111 of the anchoring plate 110 is made of braided metal wire, and the braided first skeleton 111 is double-layered inside and outside. Specifically, the metal wire diffuses and extends from the proximal end to the distal end of the anchoring disc 110 to form the inner layer of the first skeleton 111 , and then turns back from the distal end to the proximal end to weave to form the outer layer of the first skeleton 111 .

In this embodiment, the second skeleton 121 of the sealing disc 120 is a wire braided structure, and the sealing disc 120 includes a disc surface 127 facing away from the anchoring disc 110, a disc bottom 128 facing the anchoring disc 110, and a disc surface 128 connected to the disc surface. Waist 129 between 127 and dish bottom 128. Wherein, the diameter of the disk surface 127 is larger than the diameter of the disk bottom 128, and the diameter of the disk surface 127 is slightly larger than the inner diameter of the left atrial appendage. The diameter is approximately the same as the inner diameter of the left atrial appendage.

At the same time, in the left atrial appendage occlusion ablation device shown in this embodiment, the second conductive part 114 on the anchor plate 110 is part of the first frame 111. It can be understood that a specific frame or an additional setting can also be used according to requirements. way of electrodes. The whole second frame 121 of the sealing disc 120 serves as the first conductive part 122 .

Example 11

FIG. 19 is a schematic structural view of the left atrial appendage occlusion ablation device provided in this embodiment, and FIG. 20 is a structural schematic view of the left atrial appendage occlusion ablation device in FIG.

Please refer to FIG. 19 and FIG. 20 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the anchoring disc 110 is different.

In this embodiment, the first skeleton 111 of the anchoring disc 110 is made of braided metal wire, while in the first embodiment the first skeleton 111 of the anchoring disc 110 is cut from a pipe. The first skeleton 111 and the second skeleton 121 in this application do not limit the manufacturing process, the first skeleton 111 can be woven or cut, and the second skeleton 121 can also be woven or cut.

As shown in FIGS. 19-20 , the distal end of the first frame 111 is open, that is, the distal end of the first frame 111 has an opening, so that the shape of the first frame 111 is cup-shaped.

At the same time, in the left atrial appendage blockage ablation device shown in this embodiment, the anchor plate 110 can use part or all of the first skeleton 111 as the second conductive part 114 according to requirements, or can also use the external first electrode part 116 as the second conductive portion 114 .

Example 12

FIG. 21 is a schematic diagram of the structure of the left atrial appendage ablation device provided in this embodiment after removing the film, and FIG. 22 is a schematic diagram of the structure of the first frame 111 in the left atrial appendage ablation device in FIG. 21 .

Please refer to FIG. 21 and FIG. 22 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the anchoring disc 110 is different.

In this embodiment, the anchoring plate 110 is made by cutting a pipe. The difference from the first frame 111 in this embodiment is that the two adjacent anchoring parts 113 of the first frame 111 in this embodiment are independently provided, that is, their Any anchor portion 113 is not directly connected to other anchor portions 113 . The anchoring portion 113 is rod-shaped and extends proximally, and an end of the anchoring portion 113 away from the first connection point 1124 is bent inward.

Similarly, the second conductive part 114 in the left atrial appendage occlusion ablation device provided in this embodiment can also adopt a skeleton or additionally provide electrode parts according to requirements.

Example 13

Fig. 23 is a schematic structural diagram of the left atrial appendage occlusion ablation device provided in this embodiment.

Please refer to FIG. 23 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Example 1 in that the structure of the anchor disc 110 is different, specifically, the anchor The structure of the fixed portion 113 is different from that of the first embodiment.

In this embodiment, the anchoring plate 110 is made by cutting a pipe, and each anchoring portion 113 includes a third branch 1132 and a fourth branch 1133 whose distal ends are connected to each other. The third branch 1132 and the fourth branch 1133 The connection forms a second connection point 1134 connected to the first connection point 1124 . Meanwhile, the proximal end of each third branch 1132 is connected to the proximal end of the fourth branch 1133 of an adjacent anchoring portion 113 , thus forming a grid structure between two adjacent anchoring portions 113 .

Further, the anchoring part 113 also includes a connecting rod 1131, and the two ends of the connecting rod 1131 are respectively connected to the first connecting point 1124 and the second connecting point 1134, so that the grid formed between two adjacent anchoring parts 113 It is hexagonal. The barb 117 is disposed on the connecting rod 1131 .

The electrode wires on the first branch 1122 and the second branch 1123 serve as the first electrode member 116 . Specifically, a part of the electrode wire is helically wound along the circumferential direction of the first branch 1122 , so as to be wound around the first branch 1122 . The other part of the electrode wire is spirally wound along the circumferential direction of the second branch 1123 , so as to be wound around the second branch 1123 . The first electrode member 116 can serve as the second conductive portion 114 . It can be understood that, in some other embodiments, other forms of the second conductive portion 114 may also be used, such as the structure of the second conductive portion 114 provided in Embodiment 1 or Embodiment 7.

Example 14

FIG. 24 is a schematic structural view of the left atrial appendage occlusion ablation device provided in this embodiment, and FIG. 25 is a structural schematic view of the left atrial appendage occlusion ablation device in FIG. 24 after removing the membrane.

Please refer to FIG. 24 and FIG. 25 , this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the structure of the ablation bracket 100 is different.

In this embodiment, the ablation stent 100 has a three-disk structure, and the second conductive part 114 and the first conductive part 122 are respectively arranged on any two of the three discs. At the same time, the second conductive part 114 can choose a skeleton or an additional electrode part according to requirements.

Similarly, the left atrial appendage occlusion ablation device provided in this embodiment may also adopt related structures in other embodiments. Specifically, the three discs of the ablation stent 100 are respectively a first disc 161 , a second disc 162 and a third disc 163 arranged in sequence from the distal end to the proximal end.

In some embodiments, the first plate 161 and the second plate 162 are connected and electrically isolated by an insulating connector 130 , and the insulating connector 130 may also be replaced by an insulating frame. At this time, whether the second disk 162 and the third disk 163 are electrically isolated is not limited.

In some embodiments, the second disk 162 and the third disk 163 are connected and electrically isolated by another insulating connector 130 , and the insulating connector 130 may also be replaced by an insulating frame. At this time, whether the first disk 161 and the second disk 162 are electrically isolated is not limited.

In some embodiments, the first disk 161 and the second disk 162 are connected and electrically isolated through an insulating connector 130, while the second disk 162 and the third disk 163 are connected and electrically isolated through another insulating connector 130. , The insulating connector 130 may also be replaced by an insulating frame. In some embodiments, the third disc 163 can serve as the sealing disc 120 , and both the second disc 162 and the first disc 161 can serve as the anchoring disc 110 . The third plate 163 conducts electricity as a whole and serves as the first conductive portion 122 . The second conductive part 114 may be disposed on any one of the second plate 162 or the first plate 161 .

As shown in FIG. 24 and FIG. 25 , in this embodiment, the first electrode member 116 is disposed on the first plate 161 as the second conductive portion 114 , and the second electrode member 123 is disposed on the second plate 162 as the third conductive portion. superior. It can be understood that only the first pole piece 116 may be provided without the second pole piece 123 .

When the first pole member 116 is provided on the first plate 161 as the second conductive part 114, it can only be insulated and connected between the first plate 161 and the second plate 162, and between the second plate 162 and the third plate 163 Whether it is electrically isolated or not is not limited. Alternatively, only the insulating connection between the second pad 162 and the third pad 163 may be made, and whether the first pad 161 and the second pad 162 are electrically isolated is not limited. Alternatively, the second disk 162 is made of an insulating material, and there is no limitation on whether the first disk 161 is electrically isolated from the second disk 162 , and whether the second disk 162 is electrically isolated from the third disk 163 is also not limited.

In this embodiment, the first disk 161 is used for anchoring inside the left atrial appendage, the third disk 163 is used as the sealing disk 120 to block the opening of the left atrial appendage, and the second disk 162 is located near the opening of the left atrial appendage.

Example 15

Fig. 26 is a schematic structural view of the left atrial appendage occlusion ablation device provided by Embodiment 15 of the present invention;

FIG. 27 is a schematic structural diagram of the movable member 150 in FIG. 26 , and FIG. 27 is a schematic structural diagram of the first type of movable member 150 .

Please refer to Fig. 26 and Fig. 27, this embodiment also provides a left atrial appendage blockage ablation device, the main difference between it and the left atrial appendage blockage ablation device provided in embodiment 1 is that a movable part 150 is added, the movable part 150 is used to transmit ablation energy or collect tissue physiological signals, and the movable part 150 can be relatively movably arranged on the sealing disc 120 and the anchoring disc 110 . And after the tissue ablation is completed, the movable part 150 can be separated from the sealing disc 120 and the anchoring disc 110 and withdrawn from the body, leaving only the sealing disc 120 and the anchoring disc 110 in the body.

In this embodiment, the left atrial appendage blockage ablation device includes a sealing disc 120 , an anchoring disc 110 and a movable member 150 movably arranged on the anchoring disc 110 .

In some embodiments, the sealing disc 120 is connected to the anchoring disc 110 through an insulating connector 130 . The proximal end of the movable part 150 moves through the cavity in the insulating connecting part 130 . The distal end of the movable member 150 is movably arranged on the distal end or the outer peripheral side of the anchoring disc 110 . It can be understood that the insulating connector 130 can also be replaced by an insulating frame.

In some embodiments, the movable part 150 and the anchoring plate 110 are insulated, so whether the sealing plate 120 and the anchoring plate 110 are insulated or not is not limited.

All or part of the movable part 150 is made of conductive material. In some embodiments, the movable element 150 can be movably disposed on the distal end or the outer peripheral side of the anchoring disc 110 as the second conductive part 114 . At this time, the second catheter 141 may be connected to the movable part 150 and electrically connected to provide ablation energy for the movable part 150 .

In some other embodiments, the movable element 150 may also be movably disposed on the distal end or the outer peripheral side of the anchoring disc 110 as a third conductive portion independent of the second conductive portion 114 . The second conductive portion 114 may be part or all of the first frame 111 of the anchoring plate 110 , and may also be the first electrode member 116 independent of the first frame 111 . At this time, the second catheter 141 can be electrically connected to the second conductive part 114 to provide ablation energy for the second conductive part 114; the third catheter is passed through the second catheter 141 and electrically connected to the movable part 150 to serve as 150 (ie the third conductive part) provides ablation energy.

Please refer to FIG. 27 , the movable part 150 of this embodiment is a network disk structure, and its distal end is stretchable in the radial direction. When the movable part 150 is released at the distal end of the anchoring disk 110, the movable part 150 expands radially.

The movable part 150 may be an ablation disc made of braided metal wire, or an ablation disc made of cut metal tubing. A converging portion 1501 is formed at the proximal end of the ablation disk. The ablation disk has a double-layer network disk structure, that is, both the proximal end and the distal end of the ablation disk are provided with a grid-shaped network disk structure, and the network disk structure extends radially.

FIG. 28 is a second structural schematic diagram of the movable member 150 in FIG. 26 .

Please refer to FIG. 28 , the structure of the movable member 150 in this embodiment is different from that of the movable member 150 in FIG. 27 . In this embodiment, the movable element 150 includes a first portion 1511 , a second portion 1512 and a third portion 1513 sequentially connected in a radial direction. The first part 1511 is used for connecting wires, so as to be electrically connected with an external ablation signal source. The second portion 1512 extends radially outward from the first portion 1511 . The third portion 1513 is bent from the outer end of the second portion 1512 and extends radially inward.

It can be understood that the third part 1513 can be bent upwards or downwards from the outer end of the second part 1512 .

FIG. 29 is a schematic diagram of a third structure of the movable member 150 in FIG. 26 .

Please refer to FIG. 29 , the structure of the movable member 150 in this embodiment is different from that of the movable member 150 in FIG. 27 . In this embodiment, the movable part 150 is in the shape of an umbrella rib as a whole, and can expand and contract in the radial direction. The movable part 150 can be made by cutting a metal pipe.

Specifically, the movable member 150 includes a plurality of first struts 1521 and a plurality of second struts 1522 . The plurality of first struts 1521 extend radially outward, and the distance between adjacent first struts 1521 gradually increases in the radially outward direction. The plurality of first struts 1521 form a stent structure that gradually expands radially from the proximal end to the distal end. The plurality of second struts 1522 are disposed around the outer circumference of the plurality of first struts 1521 , and are gradually bent and extended from the distal end to the proximal end. The distal end of the second rod 1522 is connected with the outer end of the first rod 1521 . A plurality of second struts 1522 may also be used to anchor the inner wall tissue of the left atrial appendage.

In the embodiment shown in FIG. 29 , the movable member 150 further includes a plurality of first connecting rods 1523 and second connecting rods 1524 connected between the first rod 1521 and the second rod 1522 . The end of each first rod 1521 away from the axis of the movable member 150 is connected with a first connecting rod 1523 and a second connecting rod 1524 to form a Y-shaped structure. The end of the first connecting rod 1523 away from the first pole 1521 is connected to the end of another adjacent second connecting rod 1524 away from the first pole 1521 to form a third connection point 1525 . The distal end of the second rod 1522 is connected to the third connection point 1525 . The proximal end of the second strut 1522 is bent radially inward, and is gradually hooked back toward the distal end, so as to prevent the second strut 1522 from penetrating into the inner wall tissue of the left atrial appendage and reduce damage to the tissue.

The movable part 150 is in the shape of an umbrella rib as a whole, which is convenient for release and recovery. At the end of the ablation, the movable member 150 can be pulled by the second catheter 141 in the conveyor 140 to move proximally and retracted into the first catheter 142 . Or the movable part 150 is pulled to move proximally by the third catheter, and is retracted into the second catheter 141 .

FIG. 30 is a schematic diagram of a fourth structure of the movable member 150 in FIG. 26 .

Please refer to FIG. 30 , the structure of the movable member 150 in this embodiment is different from that of the movable member 150 in FIG. 27 . In this embodiment, the movable element 150 is in a tubular structure as a whole. Specifically, the movable part 150 includes a tube body 153 and a plurality of tube electrodes 154 disposed on the tube body 153 at intervals.

Wherein, the tube body 153 includes an axial section 1531 , an extension section 1532 and a ring section 1533 which are sequentially connected from the proximal end to the distal end.

The shaft section 1531 is used to connect with an ablation signal source. When the movable member 150 is used as the second conductive part 114 , the shaft section 1531 is detachably connected or integrally connected with the second conduit 141 . When the movable member 150 is used as a third conductive part independent of the second conductive part 114 , the shaft section 1531 is detachably connected or integrally connected with the third conduit, and is movably passed through the second conduit 141 .

The extension section 1532 extends radially outward from the distal end of the shaft section 1531 .

The ring segment 1533 extends in a ring shape around the circumference of the shaft segment 1531 from the end of the extension segment 1532 away from the shaft segment 1531 . A plurality of tube electrodes 154 are arranged at intervals on the extension section 1532 and the ring section 1533 .

In some embodiments, among the plurality of tube electrodes 154, adjacent tube electrodes 154 may be connected to the same ablation electrical signal; or may be connected to different ablation electrical signals, such as alternately connecting positive and negative ablation signal sources sequentially.

In some other embodiments, the movable part 150 can also be used to collect electrophysiological signals inside the left atrial appendage, and correspondingly, the tube electrodes 154 can be used for mapping.

FIG. 31 is a schematic diagram of a fifth structure of the movable member 150 in FIG. 26 .

Please refer to FIG. 31 , the structure of the movable member 150 in this embodiment is substantially the same as that of the movable member 150 in FIG. 30 , the main difference is that the structure of the annular segment 1533 is different. In this embodiment, the annular segment 1533 surrounds the axial segment 1531 in a spiral shape as a whole, and it can surround the axial segment 1531 in a plane spiral structure, or it can gradually spiral in the axial direction of the axial segment 1531 to form a columnar shape. or cone.

Example 16

Fig. 32 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 16 of the present invention.

Please refer to Fig. 32, and in combination with Fig. 19 and Fig. 20, this embodiment also provides a left atrial appendage blockage ablation device, which is mainly different from the left atrial appendage blockage ablation device provided in Embodiment 1 in that the movable part 150 is added .

In some embodiments, the sealing disc 120 is connected to the anchoring disc 110 through an insulating connector 130 . The proximal end of the movable part 150 moves through the cavity in the insulating connecting part 130 . The distal end of the movable member 150 is movably arranged on the distal end or the outer peripheral side of the anchoring disc 110 . It can be understood that the insulating connector 130 can also be replaced by an insulating frame.

In some embodiments, the movable part 150 and the anchoring plate 110 are insulated, so whether the sealing plate 120 and the anchoring plate 110 are insulated or not is not limited.

In this embodiment, the distal end of the movable member 150 is movably arranged inside or at the distal end of the anchoring disc 110 .

The distal end of the first skeleton 111 of the anchoring disc 110 is open. The movable part 150 can move back and forth between the inside of the first frame 111 and the outside of the distal end through the opening.

In some embodiments, all or part of the movable part 150 is made of conductive material. The movable part 150 can be movably disposed inside or at the distal end of the anchoring plate 110 as the second conductive part 114 . At this time, the second conductive part 114 and the first conductive part 122 (ie, the sealing disc 120 ) are jointly ablated.

In some other embodiments, the second conductive part 114 may be part or all of the first frame 111, and the movable part 150 is a third conductive part independent of the second conductive part 114, and is connected with the second conductive part 114. Galvanic isolation. At this time, the second conductive part 114 , the first conductive part 122 and the third conductive part are ablated together.

It can be understood that, the movable member 150 of this embodiment can adopt any one of the movable member 150 structures in FIG. 27 to FIG. 31 .

Example 17

Fig. 33 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 17 of the present invention.

Please refer to Fig. 33, and in combination with Fig. 32, this embodiment also provides a left atrial appendage blockage ablation device, which has roughly the same structure as the left atrial appendage blockage ablation device provided in Embodiment 16, the main difference is that the first electrode piece 116 .

In this embodiment, the first electrode member 116 is electrically isolated from the movable member 150 , that is, an insulation treatment is performed between the first electrode member 116 and the movable member 150 , and details may refer to the aforementioned insulation treatment method. The first electrode member 116 and the movable member 150 can serve as the second conductive part 114 and the third conductive part respectively, and cooperate with the first conductive part 122 to perform ablation.

Example 18

Fig. 34 is a schematic structural view of the left atrial appendage blockage ablation device provided by Embodiment 18 of the present invention.

Please refer to Fig. 34, combined with Fig. 26, this embodiment also provides a left atrial appendage blockage ablation device, which has roughly the same structure as the left atrial appendage blockage ablation device provided in Example 15, the main difference is that the electrode wire is added As the first electrode member 116 .

In this embodiment, the electrode wire is wound on the first frame 111 to form the first electrode member 116 . The first electrode member 116 formed by winding the electrode wire can be used as the second conductive part 114 .

All or part of the movable part 150 is made of conductive material. The movable part 150 can serve as the third conductive part, and ablate together with the second conductive part 114 .

It should be noted that the specific technical solutions in the above implementation manners of the present application may be applicable to each other.

While this invention has been described with reference to several exemplary embodiments, it is understood that the terms which have been used are words of description and illustration, rather than of limitation. Since the present invention can be embodied in many forms without departing from the spirit or essence of the invention, it should be understood that the above-described embodiments are not limited to any of the foregoing details, but should be construed broadly within the spirit and scope of the appended claims. , all changes and modifications falling within the scope of the claims or their equivalents shall be covered by the appended claims.

Claims (24)

1. A left atrial appendage occlusion ablation device, comprising:

the anchoring disc is of a radial telescopic support structure; and

the sealing disc is of a radial telescopic support structure and is arranged at the near end of the anchoring disc; the sealing disc is made of a conductive material, and the whole sealing disc is used as a first conductive part for transmitting ablation energy or collecting tissue physiological signals.

2. The left atrial appendage occlusion ablation device of claim 1, further comprising a second conductive portion for transmitting ablation energy or collecting tissue physiological signals, respectively; the second conductive part is arranged on the anchoring disc; the sealing disk is electrically isolated from the second electrically conductive portion.

3. The left atrial appendage occlusion ablation device of claim 2, further comprising an insulating connector disposed between the anchor disk and the sealing disk;

the insulating connecting piece extends along the axial direction, the far end of the insulating connecting piece is connected with the anchoring disc, and the near end of the insulating connecting piece is connected with the sealing disc; the insulating connector is configured to electrically isolate the second conductive portion from the seal land.

4. The left atrial appendage occlusion ablation device of claim 3, wherein a distal end of the insulating connector is provided with a first conductive connection that is electrically connected to the second conductive portion;

there is at least partial axial section insulation on the insulating connector between the first conductive connection and the sealing disk to electrically isolate the first conductive connection from the sealing disk.

5. The left atrial appendage occlusion ablation device of claim 4, wherein the insulating connector comprises a first connector and a second connector connected in series along an axial direction; the second connector is located at the proximal end of the first connector;

the anchoring disc is connected to the first connecting piece; the sealing disc is connected with the second connecting piece; the first conductive connecting part is arranged on the first connecting piece;

the insulated axial section is formed on the first connector, or on the second connector, or between the first connector and the second connector.

6. The left atrial appendage occlusion ablation device of claim 5, wherein the insulating connector further comprises a third connector disposed between the first connector and the second connector; the insulated axial section is formed on the third connector.

7. The left atrial appendage occlusion ablation device of claim 5, wherein a plurality of the third connectors are provided, and the plurality of third connectors are axially connected in sequence; wherein the third connector at the most distal end is connected to the first connector, the third connector at the most proximal end is connected to the second connector, and the insulated axial section is formed at least on one of the third connectors.

8. The left atrial appendage occlusion ablation device of claim 5, wherein a first installation space is formed in the first connector, and one end of the anchoring disk is connected in a constrained manner in the first installation space;

and/or a second mounting space is formed on the second connecting piece, and the far end of the sealing disc is converged in the second mounting space.

9. A left atrial appendage occlusion ablation device as in claim 6, wherein the first conductive connection is removably connected to the first connector.

10. The left atrial appendage occlusion ablation device of claim 9, wherein the insulating connector further comprises a fourth connector disposed between the first connector and the first conductive connection;

the fourth connector has the insulated axial section formed thereon to electrically isolate the first conductive connection from the first connector;

the third connector has the insulated axial section formed thereon to electrically isolate the first connector from the third connector.

11. A left atrial appendage occlusion ablation device as in claim 3, wherein the anchoring disk comprises a first backbone; the first framework is a radially telescopic support structure; the first framework is made of metal wires in a weaving mode or metal pipes in a cutting mode;

the far end of the insulating connecting piece is connected with the first framework;

the second conductive part is part or all of the first framework, or the second conductive part is an electrode element arranged on the peripheral wall of the first framework.

12. The left atrial appendage occlusion ablation device of claim 1, wherein the anchor disk comprises a support portion and an anchor portion;

the supporting parts are arranged in plurality and surround the axis of the anchoring disc; one end of the supporting part is connected with the sealing disc, and the other end of the supporting part is bent and extended outwards gradually along the radial direction;

the anchoring parts are arranged in a plurality and surround the periphery of the supporting part; the anchoring part is bent and extended towards the proximal end from the end part of the supporting part far away from the axis of the anchoring disc.

13. A left atrial appendage occlusion ablation device as in claim 12, wherein each support portion comprises a support rod, a first branch and a second branch;

one end of the supporting rod is connected to the sealing disc, and the other end of the supporting rod is bent and extended outwards gradually along the radial direction;

one end of each of the first branch and the second branch is connected to one end, far away from the axis of the anchoring disc, of the corresponding supporting rod; one end of the first branch, which is far away from the supporting rod, is connected with one end of the second branch, which is far away from the supporting rod, of the adjacent supporting part, and a connecting point is formed; the anchoring portion extends from the connection point toward the proximal end.

14. A left atrial appendage closure ablation device as in claim 13, wherein the end of the anchoring portion distal from the connection point is bent toward the axis of the anchoring disk.

15. A left atrial appendage occlusion ablation device as in claim 14, wherein an end of the anchor portion distal from the connection point is crimped to an end of another adjacent anchor portion distal from the connection point.

16. The left atrial appendage occlusion ablation device of claim 4, wherein the insulating connector has an axially extending channel formed therein, the channel extending from a proximal end of the insulating connector to the first conductive connection.

17. The left atrial appendage occlusion ablation device of claim 2, further comprising a movable member that movably passes through the anchor disk and the sealing disk; the movable part is used for transmitting ablation energy or collecting tissue physiological signals, and the movable part serves as the second conductive part or a third conductive part electrically isolated from the second conductive part.

18. The left atrial appendage occlusion ablation device of claim 17, wherein a distal end of the anchor disk is provided with an opening;

the distal end of the moveable member is capable of moving through the opening from the interior of the anchor plate to the distal side of the anchor plate or from the distal side of the anchor plate to the interior of the anchor plate.

19. The left atrial appendage closure ablation device of claim 17, wherein the distal end of the moveable member is a radially retractable structure, the distal end of the moveable member being releasable and in a radially expanded state.

20. The left atrial appendage occlusion ablation device of claim 2, wherein a second conductive connection is formed at a proximal end of the sealing disk and is configured to receive ablation energy or transmit tissue physiological signals; the second conductive connecting portion is cylindrical, and a through hole extending in the axial direction is formed in the second conductive connecting portion.

21. A left atrial appendage occlusion ablation device as in claim 20, wherein the sealing disk comprises a second skeleton, the second skeleton is a radially retractable support structure, and the second skeleton is woven from metal wires or cut from metal tubing; and the near end of the second framework is connected to the second conductive connecting part in a converging manner.

22. A left atrial appendage closure ablation device as in claim 21, wherein the outer peripheral wall of the distal end of the second backbone is provided with an insulating membrane that is blocked between the distal end of the second backbone and the proximal end of the anchor disk.

23. A left atrial appendage occlusion ablation device of any one of claims 2-22; the left atrial appendage occlusion ablation device is characterized by further comprising an outer tube, a first catheter and a second catheter;

the outer pipe is tubular, and the distal end of the outer pipe can accommodate the anchoring disc and the sealing disc in a radial contraction state;

the first guide pipe is movably arranged in the outer pipe in a penetrating way and can move relative to the outer pipe along the axial direction; the distal end of the first conduit is in electrically conductive connection with the sealing disk;

the second guide pipe is movably arranged in the first guide pipe in a penetrating way and can move relative to the first guide pipe along the axial direction; the distal end of the second conduit is movably disposed through the sealing disk and is in electrically conductive communication with the second electrically conductive portion.

24. A left atrial appendage occlusion ablation device of any one of claims 17-19; when the movable piece is used as a third conductive part electrically isolated from the second conductive part, the left atrial appendage occlusion ablation device further comprises an outer tube, a first catheter, a second catheter and a third catheter;

the outer tube is tubular, and the distal end of the outer tube can accommodate the anchoring disc and the sealing disc in a radial contraction state;

the first guide pipe is movably arranged in the outer pipe in a penetrating way and can move relative to the outer pipe along the axial direction; the distal end of the first conduit is in conductive communication with the sealing disk to transmit ablation energy to the sealing disk;

the second guide pipe is movably arranged in the first guide pipe in a penetrating way and can move relative to the first guide pipe along the axial direction; the distal end of the second conduit movably passes through the sealing disc and is electrically connected with the second conductive part;

the third guide pipe is movably arranged in the second guide pipe in a penetrating way and can move relative to the second guide pipe along the axial direction; the distal end of the third catheter is electrically connected to the third conductive portion.

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