CN115546342A - Dual energy CT image generation method, device, electronic equipment and readable storage medium - Google Patents
Dual energy CT image generation method, device, electronic equipment and readable storage medium Download PDFInfo
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Abstract
本发明公开了一种双能CT图像生成方法、装置、电子设备和可读存储介质,属于CT图像处理技术领域。所述双能CT图像生成方法包括:获取第一能量扫描图像和第二能量扫描图像,所述第一能量和所述第二能量不同;根据所述第一能量扫描图像和预测模型获取第二能量预测图像,所述预测模型根据第一能量历史扫描图像和第二能量历史扫描图像预先训练得到;根据所述第二能量预测图像和所述第二能量扫描图像获取第二能量合成图像,将所述第二能量合成图像和所述第一能量扫描图像确定为双能CT图像。
The invention discloses a dual-energy CT image generation method, device, electronic equipment and readable storage medium, belonging to the technical field of CT image processing. The dual-energy CT image generation method includes: acquiring a first energy scan image and a second energy scan image, the first energy and the second energy are different; acquiring the second energy scan image according to the first energy scan image and a prediction model An energy prediction image, the prediction model is pre-trained according to the first energy history scan image and the second energy history scan image; a second energy composite image is obtained according to the second energy prediction image and the second energy scan image, and the The second energy composite image and the first energy scanning image are determined to be dual-energy CT images.
Description
技术领域technical field
本发明涉及CT图像处理技术领域,特别涉及一种双能CT图像生成方法、装置、电子设备和可读存储介质。The present invention relates to the technical field of CT image processing, in particular to a dual-energy CT image generation method, device, electronic equipment and readable storage medium.
背景技术Background technique
计算机X射线断层扫描(computer tomography,CT)是利用X射线照射被测目标,通过计算机处理获得被测目标断层图像的技术。双能CT是通过两次不同能量的扫描来获取被测目标图像的方式。基于不同物质对于不同能量X射线的衰减系数具有特异性,通过双能CT扫描能够准确地推算出不同物体的成分构成,从而生成准确的被测目标图像。Computer tomography (computer tomography, CT) is a technology that uses X-rays to irradiate the target to be measured, and obtains a tomographic image of the target through computer processing. Dual-energy CT is a way to obtain images of the measured target through two scans with different energies. Based on the specificity of the attenuation coefficients of different substances for different energy X-rays, the composition of different objects can be accurately calculated through dual-energy CT scanning, thereby generating accurate images of the measured target.
但是,相关技术中双能CT在两次扫描之间存在无法避免的时间间隔,在该时间间隔内,造影剂随血液流动以及脏器的正常运动都导致两次扫描所获取图像具有差异,进而导致不同能量扫描图像匹配度不佳,影响后续治疗和诊断。However, in the related art, dual-energy CT has an unavoidable time interval between two scans. During this time interval, the contrast agent flows with the blood and the normal movement of organs leads to differences in the images obtained by the two scans, and thus This leads to poor matching of scanning images with different energies, which affects subsequent treatment and diagnosis.
发明内容Contents of the invention
本发明要解决的技术问题是为了克服现有技术中双能CT扫描图像匹配度低的缺陷,提供一种一种双能CT图像生成方法、装置、电子设备和可读存储介质。The technical problem to be solved by the present invention is to provide a dual-energy CT image generation method, device, electronic equipment and readable storage medium in order to overcome the defect of low matching degree of dual-energy CT scanning images in the prior art.
本发明是通过下述技术方案来解决上述技术问题:The present invention solves the above technical problems through the following technical solutions:
第一方面,本发明实施例提供了一种双能CT图像生成方法,所述方法包括:In a first aspect, an embodiment of the present invention provides a method for generating a dual-energy CT image, the method comprising:
获取第一能量扫描图像和第二能量扫描图像,所述第一能量和所述第二能量不同;acquiring a first energy scan image and a second energy scan image, the first energy and the second energy being different;
根据所述第一能量扫描图像和预测模型获取第二能量预测图像,所述预测模型根据第一能量历史扫描图像和第二能量历史扫描图像预先训练得到;Acquiring a second energy prediction image according to the first energy scan image and a prediction model, the prediction model being pre-trained according to the first energy history scan image and the second energy history scan image;
根据所述第二能量预测图像和所述第二能量扫描图像获取第二能量合成图像,将所述第二能量合成图像和所述第一能量扫描图像确定为双能CT图像。Acquiring a second energy composite image according to the second energy prediction image and the second energy scanning image, and determining the second energy composite image and the first energy scanning image as a dual-energy CT image.
在一个实施例中,所述根据所述第二能量预测图像和所述第二能量扫描图像获取第二能量合成图像,包括:In one embodiment, the acquiring a second energy composite image according to the second energy prediction image and the second energy scanning image includes:
对比所述第二能量预测图像和所述第二能量扫描图像获取非一致像素;Comparing the second energy prediction image and the second energy scan image to obtain non-consistent pixels;
基于所述非一致像素获取融合掩膜;Obtaining a fusion mask based on the non-uniform pixels;
根据所述融合掩膜对所述第二能量扫描图像和所述第二能量预测图像进行图像融合,得到所述第二能量合成图像。performing image fusion on the second energy scanning image and the second energy prediction image according to the fusion mask to obtain the second energy synthesis image.
在一个实施例中,所述对比所述第二能量预测图像和所述第二能量扫描图像获取非一致像素,包括:In one embodiment, the comparing the second energy prediction image and the second energy scanning image to obtain non-consistent pixels includes:
将所述第二能量预测图像和所述第二能量扫描图像中CT值之差的绝对值大于或者等于设定阈值的像素作为所述非一致像素。Taking the pixels whose absolute value of the CT value difference between the second energy prediction image and the second energy scanning image is greater than or equal to a set threshold as the inconsistent pixels.
在一个实施例中,所述基于所述非一致像素确定融合掩膜,包括:In one embodiment, the determining the fusion mask based on the non-consistent pixels includes:
根据所述第一能量扫描图像中与所述非一致像素相同位置的像素,将所述非一致像素分为预测误差像素和扫描误差像素;dividing the non-consistent pixels into prediction error pixels and scanning error pixels according to the pixels at the same position as the non-consistent pixels in the first energy scanned image;
根据所述预测误差像素和所述扫描误差像素生成所述掩膜。The mask is generated from the prediction error pixels and the scanning error pixels.
在一个实施例中,所述方法还包括:In one embodiment, the method also includes:
在第一能量历史扫描图像和第二能量历史扫描图像中筛选出训练数据;filtering training data from the first energy history scan image and the second energy history scan image;
根据所述训练数据进行模型训练,得到所述预测模型。Model training is performed according to the training data to obtain the prediction model.
在一个实施例中,所述在第一能量历史扫描图像和第二能量历史扫描图像中筛选出训练数据,包括:In one embodiment, the filtering out the training data from the first energy history scan image and the second energy history scan image includes:
对所述第一能量历史扫描图像和所述第二能量历史扫描图像进行图像匹配;performing image matching on the first energy history scan image and the second energy history scan image;
将匹配达标的所述第一能量历史扫描图像和所述第二能量历史扫描图像作为所述训练数据。The first energy history scan image and the second energy history scan image that match the standard are used as the training data.
在一个实施例中,所述在第一能量历史扫描图像和第二能量历史扫描图像中筛选出训练数据,包括:In one embodiment, the filtering out the training data from the first energy history scan image and the second energy history scan image includes:
对所述第一能量历史扫描图像和所述第二能量历史扫描图像进行图像匹配;performing image matching on the first energy history scan image and the second energy history scan image;
对匹配不达标的所述第一能量历史扫描图像和所述第二能量历史扫描图像进行配准处理,并对配准处理后的图像进行二次图像匹配;Perform registration processing on the first energy history scan image and the second energy history scan image that do not meet the matching requirements, and perform secondary image matching on the registered image;
将二次图像匹配达标的所述第一能量历史图像和所述第二能量历史图像作为所述训练数据。The first energy history image and the second energy history image whose secondary image matching is satisfactory are used as the training data.
第二方面,本发明实施例提供了一种双能CT图像生成装置,所述装置包括:In a second aspect, an embodiment of the present invention provides a dual-energy CT image generation device, the device comprising:
第一获取模块,用于获取第一能量扫描图像和第二能量扫描图像,所述第一能量和所述第二能量不同;A first acquisition module, configured to acquire a first energy scan image and a second energy scan image, where the first energy is different from the second energy;
第二获取模块,用于根据所述第一能量扫描图像和预测模型获取第二能量预测图像,所述预测模型根据第一能量历史扫描图像和第二能量历史扫描图像预先训练得到;The second acquisition module is configured to acquire a second energy prediction image according to the first energy scan image and a prediction model, and the prediction model is pre-trained according to the first energy history scan image and the second energy history scan image;
确定模块,用于根据所述第二能量预测图像和所述第二能量扫描图像获取第二能量合成图像,将所述第二能量合成图像和所述第一能量扫描图像确定为双能CT图像。A determining module, configured to acquire a second energy composite image according to the second energy prediction image and the second energy scan image, and determine the second energy composite image and the first energy scan image as a dual-energy CT image .
第三方面,本发明实施例提供一种电子设备,包括存储器、处理器以及存储在存储器上并可在处理器上运行的计算机程序,所述处理器执行所述计算机程序时实现如上述第一方面所述的双能CT图像生成方法。In a third aspect, an embodiment of the present invention provides an electronic device, including a memory, a processor, and a computer program stored in the memory and operable on the processor. When the processor executes the computer program, the above-mentioned first The dual-energy CT image generation method described in the aspect.
第四方面,本发明实施例提供了一种计算机可读存储介质,其上存储有计算机程序,所述计算机程序被处理器执行时实现第一方面所提供的双能CT图像生成方法。In a fourth aspect, an embodiment of the present invention provides a computer-readable storage medium, on which a computer program is stored, and when the computer program is executed by a processor, the method for generating a dual-energy CT image provided in the first aspect is implemented.
本发明的积极进步效果在于:The positive progress effect of the present invention is:
本发明实施例提供的双能CT图像生成方法,通过第一能量扫描图像预测第二能量预测图像,以避免二次扫描时间差带来的结构差异。通过第二能量扫描图像修正第二能量预测图像,得到第二能量合成图像,以保障第二能量合成图像的准确性。进而,由第一能量扫描图像和第二能量合成图像形成双能图像,为后续治疗提供准确参考。In the dual-energy CT image generation method provided by the embodiment of the present invention, the second energy prediction image is predicted from the first energy scanning image, so as to avoid the structural difference caused by the time difference between the two scans. The second energy prediction image is corrected by using the second energy scanning image to obtain a second energy synthesis image, so as to ensure the accuracy of the second energy synthesis image. Furthermore, a dual-energy image is formed from the first energy scanning image and the second energy composite image, providing accurate reference for subsequent treatment.
附图说明Description of drawings
图1是根据一示例性实施例示出的双能CT图像生成方法的流程图;Fig. 1 is a flowchart of a method for generating a dual-energy CT image according to an exemplary embodiment;
图2是根据一示例性实施例示出的步骤S103的流程图;Fig. 2 is a flowchart of step S103 shown according to an exemplary embodiment;
图3是根据一示例性实施例示出的步骤S1032的流程图;Fig. 3 is a flowchart of step S1032 shown according to an exemplary embodiment;
图4是根据另一示例性实施例示出的双能CT图像生成方法的流程图;Fig. 4 is a flow chart of a method for generating a dual-energy CT image according to another exemplary embodiment;
图5是根据一示例性实施例示出的步骤S104的流程图;Fig. 5 is a flowchart of step S104 shown according to an exemplary embodiment;
图6是根据一示例性实施例示出的双能CT图像生成装置的框图;Fig. 6 is a block diagram of a device for generating a dual-energy CT image according to an exemplary embodiment;
图7是根据一示例性实施例示出的确定模块的框图;Fig. 7 is a block diagram of a determination module shown according to an exemplary embodiment;
图8是根据一示例性实施例示出的获取单元的框图;Fig. 8 is a block diagram of an acquisition unit shown according to an exemplary embodiment;
图9是根据另一示例性实施例示出的双能CT图像生成装置的框图;Fig. 9 is a block diagram of a dual-energy CT image generating device according to another exemplary embodiment;
图10是根据一示例性实施例示出的筛选模块的框图;Fig. 10 is a block diagram of a screening module shown according to an exemplary embodiment;
图11为根据一示例性实施例示出的一种电子设备的结构示意图。Fig. 11 is a schematic structural diagram of an electronic device according to an exemplary embodiment.
具体实施方式detailed description
下面通过实施例的方式进一步说明本发明,但并不因此将本发明限制在所述的实施例范围之中。The present invention is further illustrated below by means of examples, but the present invention is not limited to the scope of the examples.
在本公开使用的术语是仅仅出于描述特定实施例的目的,而非旨在限制本公开。除非另作定义,本公开使用的技术术语或者科学术语应当为本公开所属领域内具有一般技能的人士所理解的通常意义。本公开说明书以及权利要求书中使用的“一个”或者“一”等类似词语也不表示数量限制,而是表示存在至少一个。除非另行指出,“包括”或者“包含”等类似词语意指出现在“包括”或者“包含”前面的元件或者物件涵盖出现在“包括”或者“包含”后面列举的元件或者物件及其等同,并不排除其他元件或者物件。“连接”或者“相连”等类似的词语并非限定于物理的或者机械的连接,而且可以包括电性的连接,不管是直接的还是间接的。The terminology used in the present disclosure is for the purpose of describing particular embodiments only, and is not intended to limit the present disclosure. Unless otherwise defined, the technical terms or scientific terms used in the present disclosure shall have the usual meanings understood by those skilled in the art to which the present disclosure belongs. Words such as "a" or "one" used in the present disclosure and the claims do not indicate a limitation of quantity, but mean that there is at least one. Unless otherwise stated, "comprises" or "comprises" and similar terms mean that the elements or items listed before "comprises" or "comprises" include the elements or items listed after "comprises" or "comprises" and their equivalents, and Other elements or items are not excluded. Words such as "connected" or "connected" are not limited to physical or mechanical connections, and may include electrical connections, whether direct or indirect.
在本公开说明书和所附权利要求书中所使用的单数形式的“一种”、“所述”和“该”也旨在包括多数形式,除非上下文清楚地表示其他含义。还应当理解,本文中使用的术语“和/或”是指并包含一个或多个相关联的列出项目的任何或所有可能组合。As used in this disclosure and the appended claims, the singular forms "a", "the", and "the" are intended to include the plural forms as well, unless the context clearly dictates otherwise. It should also be understood that the term "and/or" as used herein refers to and includes any and all possible combinations of one or more of the associated listed items.
在相关技术中,双源扫描、快速kV切换扫描、双层探测器等方案由于成本过高限制了双能CT成像的临床落地。需要两次扫描的慢速kV切换扫描等方案不仅对病人带来额外剂量,而且两次采集的时间差内不可避免的造影剂流动,脏器运动等因素造成两次扫描图像的匹配度低,大大影响了成像后的临床诊断。In related technologies, dual-source scanning, fast kV switching scanning, double-layer detectors and other solutions have limited the clinical implementation of dual-energy CT imaging due to high cost. Schemes such as slow kV switching scans that require two scans not only bring additional doses to the patient, but also the inevitable contrast agent flow and organ movement within the time difference between the two acquisitions cause the low matching degree of the two scan images, greatly Clinical diagnosis after imaging is affected.
基于上述问题,本发明实施例提供了一种双能CT图像生成方法,以达到兼顾双能扫描CT图像高匹配度和低硬件成本的目的。本发明实施例所提供的技术方案适用于多种CT几何结构,包括但不限于平行束和锥束,本发明实施例所提供的技术方案适用于多种CT扫描模式,包括但不限于断层平扫和螺旋扫描。以下将结合附图对本发明实施例展开详细说明。Based on the above problems, an embodiment of the present invention provides a method for generating a dual-energy CT image, so as to achieve both a high matching degree of a dual-energy CT image and low hardware cost. The technical solutions provided by the embodiments of the present invention are applicable to various CT geometries, including but not limited to parallel beams and cone beams, and the technical solutions provided by the embodiments of the present invention are applicable to various CT scan modes, including but not limited to tomographic Sweep and helical scan. Embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.
实施例1Example 1
图1是根据一示例性实施例示出的双能CT图像生成方法的流程图。如图1所示,该方法包括:Fig. 1 is a flow chart of a method for generating a dual-energy CT image according to an exemplary embodiment. As shown in Figure 1, the method includes:
步骤S101、获取第一能量扫描图像和第二能量扫描图像,第一能量和第二能量不同。Step S101, acquiring a first energy scan image and a second energy scan image, where the first energy and the second energy are different.
第一能量扫描图像和第二能量扫描图像是同一被扫描对象在不同能谱X射线下的扫描图像。通过调控X射线管的管电压实现不同能谱的X射线。由于两次扫描具有时间差,该时间差内造影剂流动以及脏器运动等都造成第一能量扫描图像和第二扫描图像存在不可避免的结构差异。The first energy scanning image and the second energy scanning image are scanning images of the same scanned object under different energy spectrum X-rays. X-rays with different energy spectra are realized by adjusting the tube voltage of the X-ray tube. Due to the time difference between the two scans, the contrast agent flow and organ movement within the time difference cause unavoidable structural differences between the first energy scan image and the second scan image.
可选地,第一能量低于第二能量。在这样的情况下,采用相对低能谱的X射线扫描获取的第一能量扫描图像中目标区域的衰减更大,更易识别出不同的组织或部位,以为后续步骤中图像预测提供准确输入。Optionally, the first energy is lower than the second energy. In such a case, the attenuation of the target area in the first energy scanning image acquired by relatively low-energy X-ray scanning is greater, and it is easier to identify different tissues or parts, so as to provide accurate input for image prediction in subsequent steps.
可选地,采用稀疏采集和低剂量采集的方式获取第二能量扫描图像,以此方式降低被扫描对象所承受的辐射剂量。其中,稀疏采集是指以较大的间隔角度进行投影扫描,提高了采集速率,从而降低被扫描对象所承受的辐射剂量。并且,扫描剂量还与X射线管的管电流相关,通过调控X射线管的管电流得以改变扫描剂量。在步骤S101中通过降低X射线管的管电流实现低剂量采集。Optionally, the second energy scanning image is acquired by means of sparse acquisition and low-dose acquisition, so as to reduce the radiation dose borne by the scanned object. Among them, sparse acquisition refers to performing projection scanning at a larger interval angle, which improves the acquisition rate, thereby reducing the radiation dose borne by the scanned object. Moreover, the scanning dose is also related to the tube current of the X-ray tube, and the scanning dose can be changed by adjusting the tube current of the X-ray tube. In step S101, low dose acquisition is realized by reducing the tube current of the X-ray tube.
步骤S102、根据第一能量扫描图像和预测模型获取第二能量预测图像,所述预测模型根据第一能量历史扫描图像和第二能量历史扫描图像预先训练得到。Step S102. Acquire a second energy prediction image according to the first energy scanning image and a prediction model, the prediction model is pre-trained based on the first energy history scanning image and the second energy history scanning image.
结合步骤S101,第一能量较低的情况下,根据第一能量扫描图像获取的第二能量预测图像的预测准确度更高。可选地,在步骤S102中,通过深度学习的方式根据第一能量历史扫描图像和第二能量历史扫描图像训练得到所述预测模型,该预测模型的具体获取方式将在下文详细阐述。In conjunction with step S101, when the first energy is low, the prediction accuracy of the second energy prediction image acquired according to the first energy scanning image is higher. Optionally, in step S102, the prediction model is obtained through deep learning training according to the first energy history scanning image and the second energy history scanning image, and the specific acquisition method of the prediction model will be described in detail below.
步骤S103、根据第二能量预测图像和第二能量扫描图像获取第二能量合成图像,将第二能量合成图像和第一能量扫描图像确定为双能CT图像。Step S103, acquiring a second energy composite image according to the second energy prediction image and the second energy scan image, and determining the second energy composite image and the first energy scan image as a dual-energy CT image.
由于物理原理限制,第一能量图像和第二能量图像不满足完全映射(perfectmapping)关系,因此仅通过第一能量扫描图像得到的第二能量预测图像存在不确定性和误差风险。在步骤S103中,采用第二能量扫描图像对第二能量预测图像进行辅助校正获取第二能量合成图像,从而优化最终获取的双能CT图像的准确性和有效应。Due to limitations of physical principles, the first energy image and the second energy image do not satisfy a perfect mapping relationship, so the second energy prediction image obtained only through the first energy scan image has uncertainty and error risks. In step S103, the second energy scanning image is used to perform auxiliary correction on the second energy prediction image to obtain a second energy composite image, so as to optimize the accuracy and effectiveness of the finally obtained dual-energy CT image.
综上所述,本发明实施例提供的双能CT图像生成方法,通过第一能量扫描图像预测第二能量预测图像,以避免二次扫描时间差带来的结构差异。通过第二能量扫描图像修正第二能量预测图像,得到第二能量合成图像,以保障第二能量合成图像的准确性。进而,由第一能量扫描图像和第二能量合成图像形成双能图像,为后续治疗提供准确参考。In summary, the dual-energy CT image generation method provided by the embodiment of the present invention predicts the second energy prediction image through the first energy scanning image, so as to avoid the structural difference caused by the time difference between the two scans. The second energy prediction image is corrected by using the second energy scanning image to obtain a second energy synthesis image, so as to ensure the accuracy of the second energy synthesis image. Furthermore, a dual-energy image is formed from the first energy scanning image and the second energy composite image, providing accurate reference for subsequent treatment.
在一个示例中,步骤S103采用以下方式实现。图2是根据一示例性实施例示出的步骤S103的流程图。如图2所示,步骤S103包括:In an example, step S103 is implemented in the following manner. Fig. 2 is a flowchart of step S103 shown according to an exemplary embodiment. As shown in Figure 2, step S103 includes:
步骤S1031、对比第二能量预测图像和第二能量扫描图像获取非一致像素。Step S1031, comparing the second energy prediction image and the second energy scanning image to obtain non-consistent pixels.
可选地,步骤S1031具体将第二能量预测图像和第二能量扫描图像中CT值之差的绝对值大于或者等于设定阈值的像素作为非一致像素。第二能量预测图像和第二能量扫描图像中相同物质的CT值一致或相差不大,因此以CT值作为判断标准确定出二张图像中不同的像素点。Optionally, in step S1031, specifically, the pixels whose absolute value of the CT value difference between the second energy prediction image and the second energy scanning image is greater than or equal to the set threshold are regarded as inconsistent pixels. The CT values of the same substance in the second energy prediction image and the second energy scanning image are consistent or have little difference, so the different pixels in the two images are determined by using the CT value as a criterion.
步骤S1032、基于非一致像素获取融合掩膜。Step S1032, acquiring a fusion mask based on non-consistent pixels.
进一步地,根据步骤S1032中确定出的非一致像素确定融合掩膜。可选地,图3是根据一示例性实施例示出的步骤S1032的流程图。如图3所示,步骤S1032包括:Further, a fusion mask is determined according to the inconsistent pixels determined in step S1032. Optionally, Fig. 3 is a flow chart of step S1032 shown according to an exemplary embodiment. As shown in Figure 3, step S1032 includes:
步骤S301、根据第一能量扫描图像中与非一致像素相同位置的像素,将非一致像素分为预测误差像素和扫描误差像素。Step S301 , according to the pixels at the same position as the non-consistent pixels in the first energy-scanned image, divide the non-consistent pixels into prediction error pixels and scanning error pixels.
其中,预测误差像素是指由于预测误差所导致的非一致像素,扫描误差像素是指由于脏器运动以及造影剂流动等原因导致的非一致像素。其中,扫描误差像素是两次扫描过程中难以避免的像素差异。Wherein, the prediction error pixels refer to non-consistent pixels due to prediction errors, and the scanning error pixels refer to non-consistent pixels due to organ movement, contrast agent flow and other reasons. Among them, the scanning error pixels are unavoidable pixel differences in the two scanning processes.
第一能量扫描图像与第二能量扫描图像是两次实际进行的图像扫描,不可避免地存在扫描误差。第二能量预测图像是基于第一能量扫描图像预测得到的,因此第二能量预测图像和第一能量扫描图像的图像中组织结构相同,但是相同像素点的CT值具有差异。在这样的情况下,步骤S301中根据第一能量扫描图像与第二能量扫描图像能够确定出由结构差异所导致的扫描误差像素,进而将所述非一致像素划分为扫描误差像素和预测误差像素。The first energy scan image and the second energy scan image are two actual image scans, and scanning errors inevitably exist. The second energy prediction image is predicted based on the first energy scan image, so the second energy prediction image and the first energy scan image have the same tissue structure, but the CT values of the same pixel points are different. In this case, in step S301, according to the first energy scanning image and the second energy scanning image, the scanning error pixels caused by structural differences can be determined, and then the inconsistent pixels are divided into scanning error pixels and prediction error pixels .
可选地,在确定扫描误差像素时,以第一能量扫描图像、第二能量扫描图像和第二能量预测图像中的几何结构和解剖结构信息作为参考,通过图像匹配(例如基于灰度梯度进行图像匹配)等方法确定出扫描误差像素。Optionally, when determining the scanning error pixel, the geometric structure and anatomical structure information in the first energy scanning image, the second energy scanning image and the second energy prediction image are used as a reference, and image matching (for example, based on the gray gradient is performed) Image matching) and other methods to determine the scanning error pixels.
步骤S302、根据预测误差像素和扫描误差像素生成掩膜。Step S302, generating a mask according to the prediction error pixels and the scanning error pixels.
掩膜为与第一能量扫描图像和第二能量扫描图像同尺寸的矩阵。关于掩膜的实现方式,示例地,掩膜中的数值为0或1。具体来说,对于一致像素和划分为扫描误差像素的非一致像素,掩膜中对应的值为1。此时,最终第二能量合成图像采用第二能量预测图像的像素值。对于非划分为预测误差的非一致像素,掩膜中对应的值为0。此时,最终第二能量合成图像采用第二能量扫描图像的像素值。示例地,掩膜中的数值大于或者等于0,并且小于或者等于1。以此方式所获取的第二能量合成图像的图像效果更佳,特别是对于非一致像素的区域图像合成效果更真实。The mask is a matrix with the same size as the first energy scan image and the second energy scan image. Regarding the implementation of the mask, for example, the value in the mask is 0 or 1. Specifically, for consistent pixels and non-uniform pixels classified as scanning error pixels, the corresponding value in the mask is 1. At this time, the final second energy composite image adopts the pixel values of the second energy prediction image. For non-consistent pixels that are not classified as prediction errors, the corresponding value in the mask is 0. At this time, the final second energy synthesis image adopts the pixel values of the second energy scanning image. Exemplarily, the values in the mask are greater than or equal to 0 and less than or equal to 1. The image effect of the second energy synthesized image obtained in this way is better, especially the image synthesized effect is more realistic for regions with non-uniform pixels.
继续参照2,在步骤S1032之后执行步骤S1033,具体如下:Continuing to refer to 2, execute step S1033 after step S1032, specifically as follows:
步骤S1033、根据融合掩膜对第二能量扫描图像和第二能量预测图像进行图像融合,得到第二能量合成图像。Step S1033, performing image fusion on the second energy scanning image and the second energy prediction image according to the fusion mask to obtain a second energy composite image.
结合上述对步骤S302的阐述,此处第二能量合成图像采用以下方式获取:Combined with the above description of step S302, here the second energy composite image is acquired in the following manner:
Image_synthetic=Image_predict×mask+Image_scan×(1–mask)Image_synthetic=Image_predict×mask+Image_scan×(1–mask)
其中,Image_synthetic为第二能量合成图像,Image_predict为第二能量预测图像,Image_scan为第二能量扫描图像,mask为掩膜。Wherein, Image_synthetic is the second energy synthetic image, Image_predict is the second energy prediction image, Image_scan is the second energy scanning image, and mask is the mask.
综上所述,通过步骤S101~步骤S103生成了双能CT图像。结合本发明实施例提供的完整的双能CT图像生成方法,再次阐述步骤S101通过降低X射线管管电流以降低辐射剂量的原因。In summary, a dual-energy CT image is generated through steps S101 to S103. Combined with the complete dual-energy CT image generation method provided by the embodiment of the present invention, the reason for reducing the radiation dose by reducing the X-ray tube current in step S101 is explained again.
通常,在CT扫描时通过降低X射线管的管电流以降低辐射剂量。但是,管电流的降低会导致图像噪声增加,影响图像质量。因此,在相关技术提供的双能CT图形生成方法中,为了保障图像质量需要提高双能扫描的管电压,从而导致辐射剂量增加。Usually, the radiation dose is reduced by reducing the tube current of the X-ray tube during CT scanning. However, the reduction of the tube current will lead to the increase of image noise and affect the image quality. Therefore, in the dual-energy CT image generation method provided by the related art, in order to ensure the image quality, it is necessary to increase the tube voltage of the dual-energy scan, which leads to an increase in radiation dose.
在本发明实施例中,通过第一能量扫描图像预测第二能量预测图像,通过第二能量扫描图像优化第二能量预测图像,以提高所生成双能CT图像的准确性。因此,对于步骤S101中获取的第一能量扫描图像和第二能量扫描图像来说,降低了对图像噪声的要求。在这样的情况下,在步骤S101中进行图像扫描时可以采用更低的X射线管的管电流,从而实现降低辐射剂量的目的。In the embodiment of the present invention, the second energy prediction image is predicted by the first energy scan image, and the second energy prediction image is optimized by the second energy scan image, so as to improve the accuracy of the generated dual-energy CT image. Therefore, for the first energy scanning image and the second energy scanning image acquired in step S101, the requirement on image noise is reduced. In such a case, a lower tube current of the X-ray tube may be used when performing image scanning in step S101, so as to achieve the purpose of reducing the radiation dose.
图4是根据另一示例性实施例示出的双能CT图像生成方法的流程图。如图4所示,所述方法还包括:Fig. 4 is a flow chart of a method for generating a dual-energy CT image according to another exemplary embodiment. As shown in Figure 4, the method also includes:
步骤S104、在第一能量历史扫描图像和第二能量历史扫描图像中筛选出训练数据。Step S104, filtering out training data from the first energy history scan image and the second energy history scan image.
通过筛选优化了训练数据,使得基于该训练数据训练得到的预测模型更加准确地根据第一能量扫描图像预测出第二能量扫描图像。The training data is optimized by screening, so that the prediction model trained based on the training data can more accurately predict the second energy scanning image according to the first energy scanning image.
作为一个示例,图5是根据一示例性实施例示出的步骤S104的流程图。如图5所示,步骤S104包括:As an example, Fig. 5 is a flowchart of step S104 shown according to an exemplary embodiment. As shown in Figure 5, step S104 includes:
步骤S1041、对第一能量历史扫描图像和第二能量历史扫描图像进行图像匹配。Step S1041 , performing image matching on the first energy history scan image and the second energy history scan image.
步骤S1042、将匹配达标的第一能量历史扫描图像和第二能量历史扫描图像作为训练数据。Step S1042, using the first energy history scan image and the second energy history scan image that match the standard as training data.
步骤S1043、对匹配不达标的第一能量历史扫描图像和第二能量历史扫描图像进行配准处理,并对配准处理后的图像进行二次图像匹配。Step S1043 , performing registration processing on the first energy history scanning image and the second energy history scanning image whose matching is not up to standard, and performing secondary image matching on the image after the registration processing.
步骤S1044、将二次图像匹配达标的第一能量历史图像和第二能量历史图像作为训练数据。Step S1044 , using the first energy history image and the second energy history image that have met the secondary image matching standard as training data.
在步骤S1041中,第一能量历史扫描图像和第二能量历史扫描图像为临床数据,或者模体数据。其获取方法包括单不限于断层平扫、螺旋扫描。并且,对于图像匹配的具体方法不做限定,例如采用结构相似度、交叉相关系数作为参照进行图像匹配,和/或基于灰度梯度进行图像匹配。In step S1041, the first energy history scan image and the second energy history scan image are clinical data or phantom data. The acquisition methods include but are not limited to plain tomography and helical scanning. Moreover, the specific method of image matching is not limited, for example, image matching is performed using structural similarity and cross-correlation coefficient as a reference, and/or image matching is performed based on gray gradients.
在步骤S1042和步骤S1043中,匹配达标的标准基于所采用的图像匹配的具体方法确定,例如结构相似度大于或者等于设定阈值确定为匹配达标,将结构相似度小于设定阈值确定为匹配不达标。In step S1042 and step S1043, the standard of matching is determined based on the specific method of image matching adopted. For example, if the structural similarity is greater than or equal to the set threshold, it is determined that the matching is satisfactory, and if the structural similarity is less than the set threshold, it is determined that the matching is not Up to standard.
步骤S1042中将匹配达标的第一能量历史扫描图像和第二能量历史扫描图像作为训练数据,优化了训练数据的有效性,使得预测模型准确反映出相匹配的第一能量历史扫描图像和第二能量历史扫描图像之间的关系。In step S1042, the matched first energy history scan image and the second energy history scan image are used as training data to optimize the effectiveness of the training data so that the prediction model accurately reflects the matched first energy history scan image and the second energy history scan image. Relationships between energy history scan images.
步骤S1043和步骤S1044将匹配不达标的第一能量历史扫描图像和第二能量历史扫描图像进行配准处理,以提高第一能量历史扫描图像和第二能量历史扫描图像的匹配度。采用这样的方式,将配准处理后能够匹配达标的第一能量历史扫描图像和第二能量历史扫描图像同样作为训练数据,降低了训练数据集筛选的标准,一方面便于收集足够数量的训练数据,另一方面避免训练出的预测模型过于理想化,更贴近实际应用所获取的数据。Steps S1043 and S1044 perform registration processing on the first energy history scan image and the second energy history scan image that do not meet the matching standard, so as to improve the matching degree of the first energy history scan image and the second energy history scan image. In this way, the first energy history scan image and the second energy history scan image that can match the standard after the registration process are also used as training data, which reduces the standard of training data set screening, and on the one hand, it is convenient to collect a sufficient amount of training data , on the other hand, to avoid the trained prediction model from being too idealistic, and to be closer to the data obtained in practical applications.
继续参照图4,在步骤S104之后执行步骤S105,具体如下。Continuing to refer to FIG. 4 , step S105 is executed after step S104 , specifically as follows.
步骤S105、根据训练数据进行模型训练,得到预测模型。Step S105, perform model training according to the training data to obtain a prediction model.
可选地,采用深度学习模型得到所述预测模型。示例地,将训练数据中的第一能量历史扫描图像作为模型训练的输入数据,将训练数据中的第二能量历史扫描图像作为模型训练的金标准,通过该金标准与模型输出的图像构建损失函数。在模型训练过程中,通过损失函数收敛至预设阈值来确定预测模型。其中,步骤S105所采用的深度学习网络包括但不限于:Transformer,CNN,GAN。此外,在步骤S105中也可以采用其他算法基于训练数据获取预测模型,本发明实施例不做具体限定。Optionally, the prediction model is obtained by using a deep learning model. For example, the first energy history scan image in the training data is used as the input data for model training, the second energy history scan image in the training data is used as the gold standard for model training, and the loss is constructed by using the gold standard and the image output by the model function. In the process of model training, the prediction model is determined by the convergence of the loss function to the preset threshold. Wherein, the deep learning network used in step S105 includes but not limited to: Transformer, CNN, GAN. In addition, in step S105, other algorithms may also be used to obtain the prediction model based on the training data, which is not specifically limited in this embodiment of the present invention.
综上所述,本发明实施例提供的双能CT图像生成方法,通过第一能量扫描图像预测第二能量预测图像,以避免二次扫描时间差带来的结构差异。通过第二能量扫描图像修正第二能量预测图像,得到第二能量合成图像,以保障第二能量合成图像的准确性和可靠性。进而,由第一能量扫描图像和第二能量合成图像形成双能图像,为后续治疗提供准确参考。对于两次扫描均可采用低于相关技术中辐射剂量的方式进行扫描,降低被扫描对象所承受辐射的剂量。并且,本发明实施例提供的双能CT图像生成方法的硬件成本低,便于双能CT扫描的落地与推广。In summary, the dual-energy CT image generation method provided by the embodiment of the present invention predicts the second energy prediction image through the first energy scanning image, so as to avoid the structural difference caused by the time difference between the two scans. The second energy prediction image is corrected by using the second energy scanning image to obtain a second energy synthesis image, so as to ensure the accuracy and reliability of the second energy synthesis image. Furthermore, a dual-energy image is formed from the first energy scanning image and the second energy composite image, providing accurate reference for subsequent treatment. For the two scans, the radiation dose lower than that in the related art can be used to scan, reducing the radiation dose of the scanned object. Moreover, the hardware cost of the dual-energy CT image generation method provided by the embodiment of the present invention is low, which is convenient for implementation and popularization of dual-energy CT scanning.
实施例2Example 2
图6是根据一示例性实施例示出的双能CT图像生成装置的框图。如图6所示,该装置包括:第一获取模块610、第二获取模块620和确定模块630。Fig. 6 is a block diagram of a device for generating a dual-energy CT image according to an exemplary embodiment. As shown in FIG. 6 , the device includes: a first obtaining
第一获取模块610用于获取第一能量扫描图像和第二能量扫描图像,第一能量和第二能量不同。The first acquiring
第二获取模块620用于根据第一能量扫描图像和预测模型获取第二能量预测图像,预测模型根据第一能量历史扫描图像和第二能量历史扫描图像预先训练得到。The second obtaining
确定模块630用于根据第二能量预测图像和第二能量扫描图像获取第二能量合成图像,将第二能量合成图像和第一能量扫描图像确定为双能CT图像。The
在一个实施例中,图7是根据一示例性实施例示出的确定模块的框图。如图7所示,确定模块630包括:对比单元631、获取单元632和融合单元633。In one embodiment, Fig. 7 is a block diagram of a determining module according to an exemplary embodiment. As shown in FIG. 7 , the
对比单元631用于对比第二能量预测图像和第二能量扫描图像获取非一致像素。The comparing
获取单元632用于基于非一致像素获取融合掩膜。The acquiring
融合单元633用于根据融合掩膜对所述第二能量扫描图像和第二能量预测图像进行图像融合,得到第二能量合成图像。The
在一个实施例中,对比单元631具体用于将第二能量预测图像和第二能量扫描图像中CT值之差的绝对值大于或者等于设定阈值的像素作为非一致像素。In one embodiment, the
在一个实施例中,图8是根据一示例性实施例示出的获取单元的框图。如图8所示,获取单元632包括:划分子单元6321和生成子单元6322。In one embodiment, Fig. 8 is a block diagram of an acquisition unit according to an exemplary embodiment. As shown in FIG. 8 , the obtaining
其中,划分子单元6321用于根据第一能量扫描图像中与非一致像素相同位置的像素,将非一致像素分为预测误差像素和扫描误差像素。Wherein, the
生成子单元6322用于根据预测误差像素和扫描误差像素生成掩膜。The
在一个实施例中,图9是根据另一示例性实施例示出的双能CT图像生成装置的框图。如图9所示,该装置还包括:筛选模块640和训练模块650。In one embodiment, Fig. 9 is a block diagram of a device for generating a dual-energy CT image according to another exemplary embodiment. As shown in FIG. 9 , the device further includes: a
筛选模块640用于在第一能量历史扫描图像和第二能量历史扫描图像中筛选出训练数据。The
训练模块650用于根据训练数据进行模型训练,得到预测模型。The
在一个实施例中,图10是根据一示例性实施例示出的筛选模块的框图。如图10所示,筛选模块640包括:图像匹配单元641和第一确定单元642。In one embodiment, Fig. 10 is a block diagram of a screening module according to an exemplary embodiment. As shown in FIG. 10 , the
图像匹配单元641用于对第一能量历史扫描图像和第二能量历史扫描图像进行图像匹配。The
第一确定单元642用于将匹配达标的第一能量历史扫描图像和第二能量历史扫描图像作为训练数据。The first determining
在一个实施例中,筛选模块640还包括:配准处理单元643和第二确定单元644。In one embodiment, the
配准处理单元643用于对匹配不达标的第一能量历史扫描图像和第二能量历史扫描图像进行配准处理,并对配准处理后的图像进行二次图像匹配;The
第二确定单元644用于将二次图像匹配达标的第一能量历史图像和第二能量历史图像作为训练数据。The
综上所述,本发明实施例提供的双能CT图像生成装置,通过第一能量扫描图像预测第二能量预测图像,以避免二次扫描时间差带来的结构差异。通过第二能量扫描图像修正第二能量预测图像,得到第二能量合成图像,以保障第二能量合成图像的准确性和可靠性。进而,由第一能量扫描图像和第二能量合成图像形成双能图像,为后续治疗提供准确参考。对于两次扫描均可采用低于相关技术中辐射剂量的方式进行扫描,降低被扫描对象所承受辐射的剂量。并且,本发明实施例提供的双能CT图像生成方法的硬件成本低,便于双能CT扫描的落地与推广。To sum up, the dual-energy CT image generation device provided by the embodiment of the present invention predicts the second energy prediction image through the first energy scanning image, so as to avoid the structural difference caused by the time difference between the two scans. The second energy prediction image is corrected by using the second energy scanning image to obtain a second energy synthesis image, so as to ensure the accuracy and reliability of the second energy synthesis image. Furthermore, a dual-energy image is formed from the first energy scanning image and the second energy composite image, providing accurate reference for subsequent treatment. For the two scans, the radiation dose lower than that in the related art can be used to scan, reducing the radiation dose of the scanned object. Moreover, the hardware cost of the dual-energy CT image generation method provided by the embodiment of the present invention is low, which is convenient for implementation and popularization of dual-energy CT scanning.
实施例3Example 3
本发明实施例提供了一种电子设备,包括存储器、处理器以及存储在存储器上并可在处理器上运行的计算机程序,处理器执行计算机程序时实现如实施例1中所提供的双能CT图像生成方法。An embodiment of the present invention provides an electronic device, including a memory, a processor, and a computer program stored in the memory and operable on the processor. When the processor executes the computer program, the dual-energy CT as provided in Embodiment 1 is realized. image generation method.
可选地,该电子设备为与CT扫描装置配合的电子设备,用于基于CT扫描装置获取的图像生成双能CT图像。可选地,该电子设备为CT扫描设备。Optionally, the electronic device is an electronic device that cooperates with a CT scanning device, and is configured to generate a dual-energy CT image based on an image acquired by the CT scanning device. Optionally, the electronic device is a CT scanning device.
图11为本实施例提供的一种电子设备的结构示意图。所述电子设备包括至少一个处理器以及与所述至少一个处理器通信连接的存储器。其中,所述存储器存储有可被所述至少一个处理器运行的计算机程序,所述计算机程序被所述至少一个处理器执行,以使所述至少一个处理器能够执行实施例1的双能CT图像生成方法。图11所显示的电子设备3仅仅是一个示例,不应对本发明实施例的功能和使用范围带来任何限制。FIG. 11 is a schematic structural diagram of an electronic device provided in this embodiment. The electronic device includes at least one processor and a memory communicatively coupled to the at least one processor. Wherein, the memory stores a computer program that can be executed by the at least one processor, and the computer program is executed by the at least one processor, so that the at least one processor can execute the dual-energy CT of Embodiment 1 image generation method. The
电子设备3的组件可以包括但不限于:上述至少一个处理器4、上述至少一个存储器5、连接不同系统组件(包括存储器5和处理器4)的总线6。Components of the
总线6包括数据总线、地址总线和控制总线。The
存储器5可以包括易失性存储器,例如随机存取存储器(RAM)51和/或高速缓存存储器52,还可以进一步包括只读存储器(ROM)53。The
存储器5还可以包括具有一组(至少一个)程序模块54的程序/实用工具55,这样的程序模块54包括但不限于:操作系统、一个或者多个应用程序、其它程序模块以及程序数据,这些示例中的每一个或某种组合中可能包括网络环境的实现。
处理器4通过运行存储在存储器5中的计算机程序,从而执行各种功能应用以及数据处理,例如上述双能CT图像生成方法。The
电子设备3也可以与一个或多个外部设备7(例如键盘、指向设备等)通信。这种通信可以通过输入/输出(I/O)接口8进行。并且,电子设备3还可以通过网络适配器9与一个或者多个网络(例如局域网(LAN),广域网(WAN)和/或公共网络,例如因特网)通信。如图11所示,网络适配器9通过总线6与电子设备3的其它模块通信。应当明白,尽管图11中未示出,可以结合电子设备3使用其它硬件和/或软件模块,包括但不限于:微代码、设备驱动器、冗余处理器、外部磁盘驱动阵列、RAID(磁盘阵列)系统、磁带驱动器以及数据备份存储系统等。
应当注意,尽管在上文详细描述中提及了电子设备的若干单元/模块或子单元/模块,但是这种划分仅仅是示例性的并非强制性的。实际上,根据本发明的实施方式,上文描述的两个或更多单元/模块的特征和功能可以在一个单元/模块中具体化。反之,上文描述的一个单元/模块的特征和功能可以进一步划分为由多个单元/模块来具体化。It should be noted that although several units/modules or subunits/modules of an electronic device are mentioned in the above detailed description, such division is only exemplary and not mandatory. Actually, according to the embodiment of the present invention, the features and functions of two or more units/modules described above may be embodied in one unit/module. Conversely, the features and functions of one unit/module described above can be further divided to be embodied by a plurality of units/modules.
实施例4Example 4
本发明实施例提供了一种计算机可读存储介质,其上存储有计算机程序,其特征在于,计算机程序被处理器执行时实现如实施例1中的双能CT图像生成方法。An embodiment of the present invention provides a computer-readable storage medium on which a computer program is stored, and is characterized in that, when the computer program is executed by a processor, the method for generating a dual-energy CT image as in Embodiment 1 is implemented.
其中,可读存储介质可以采用的更具体可以包括但不限于:便携式盘、硬盘、随机存取存储器、只读存储器、可擦拭可编程只读存储器、光存储器件、磁存储器件或上述的任意合适的组合。Wherein, the readable storage medium may more specifically include but not limited to: portable disk, hard disk, random access memory, read-only memory, erasable programmable read-only memory, optical storage device, magnetic storage device or any of the above-mentioned the right combination.
在可能的实施方式中,本发明还可以实现为一种程序产品的形式,其包括程序代码,当程序产品在终端设备上运行时,程序代码用于使终端设备执行实现上述第二方面提供的脉冲消融区域预测方法中的步骤。In a possible implementation manner, the present invention can also be implemented in the form of a program product, which includes program code. When the program product runs on the terminal device, the program code is used to make the terminal device execute the above-mentioned second aspect. Steps in the pulse ablation region prediction method.
其中,可以以一种或多种程序设计语言的任意组合来编写用于执行本发明的程序代码,程序代码可以完全地在用户设备上执行、部分地在用户设备上执行、作为一个独立的软件包执行、部分在用户设备上部分在远程设备上执行或完全在远程设备上执行。Wherein, the program code for executing the present invention may be written in any combination of one or more programming languages, and the program code may be completely executed on the user equipment, partially executed on the user equipment, or used as an independent software Package execution, partly on the user device and partly on the remote device, or entirely on the remote device.
虽然以上描述了本发明的具体实施方式,但是本领域的技术人员应当理解,这仅是举例说明,本发明的保护范围是由所附权利要求书限定的。本领域的技术人员在不背离本发明的原理和实质的前提下,可以对这些实施方式做出多种变更或修改,但这些变更和修改均落入本发明的保护范围。Although the specific implementation of the present invention has been described above, those skilled in the art should understand that this is only an example, and the protection scope of the present invention is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principle and essence of the present invention, but these changes and modifications all fall within the protection scope of the present invention.
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