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CN115666594A - Cart细胞在制备治疗癌症的药物中的应用 - Google Patents

Cart细胞在制备治疗癌症的药物中的应用 Download PDF

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Publication number
CN115666594A
CN115666594A CN202080080390.1A CN202080080390A CN115666594A CN 115666594 A CN115666594 A CN 115666594A CN 202080080390 A CN202080080390 A CN 202080080390A CN 115666594 A CN115666594 A CN 115666594A
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cart cell
cell
cart
car
domain
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王峰
郭徽
刘妍
张捷
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Suzhou Novotech Pharmaceutical Technology Co ltd
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Suzhou Novotech Pharmaceutical Technology Co ltd
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Abstract

本发明提供嵌合抗原受体(CAR)修饰的T(CART)细胞在制备治疗癌症的药物中的应用，所述CART细胞含有人工导入的共刺激信号传导结构域，且所述CART细胞不含有人工导入的第一信号传导结构域。

Description

PCT国内申请，说明书已公开。

Claims (19)

  1. PCT国内申请，权利要求书已公开。
CN202080080390.1A 2019-11-29 2020-11-29 Cart细胞在制备治疗癌症的药物中的应用 Pending CN115666594A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116606884A (zh) * 2023-07-17 2023-08-18 广东赛尔生物科技有限公司 一种制备car-t细胞的方法以及制得的car-t细胞及其应用
WO2025035746A1 (zh) * 2023-08-15 2025-02-20 福建医科大学附属协和医院 一种靶向b7-h3并共表达细胞因子和趋化因子的car-t细胞及其用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
CN111944850B (zh) * 2020-08-28 2023-03-31 澳门大学 表达抗cd22嵌合抗原受体和pd-l1阻断蛋白的细胞的制备方法、表达载体及应用
WO2023047098A2 (en) * 2021-09-21 2023-03-30 Quell Therapeutics Ltd Anti-p75ntr chimeric antigen receptor
US20250000978A1 (en) * 2021-11-04 2025-01-02 The General Hospital Corporation Anti-mesothelin car t cells secreting teams and methods of use thereof
US20240368273A1 (en) * 2023-05-03 2024-11-07 PELL Bio-Med Technology Co., Ltd. Murine anti-cd19 chimeric antigen receptor for treating cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107523547A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抑制性抗体的car‑t细胞及其用途
CN107531805A (zh) * 2015-03-05 2018-01-02 弗雷德哈钦森癌症研究中心 免疫调节融合蛋白及其用途
CN109468278A (zh) * 2017-09-08 2019-03-15 科济生物医药（上海）有限公司 基因工程化的t细胞及应用
EP3483182A1 (en) * 2016-07-08 2019-05-15 Carsgen Therapeutics Co., Ltd. Antibody for anti-claudin 18a2 and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707189B1 (fr) 1993-07-09 1995-10-13 Gradient Ass Procédé de traitement de résidus de combustion et installation de mise en Óoeuvre dudit procédé.
ATE448301T1 (de) 2000-09-08 2009-11-15 Univ Zuerich Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
AU2002213251B2 (en) 2000-10-16 2007-06-14 Bristol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
WO2003029462A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
CA2543360A1 (en) 2003-10-24 2005-05-06 Joost A. Kolkman Ldl receptor class a and egf domain monomers and multimers
DK2049564T3 (en) 2006-08-02 2017-07-24 Uab Res Found METHODS AND COMPOSITIONS RELATED TO SOLUBLE MONOCLONAL VARIABLE Lymphocyte RECEPTORS WITH DEFINED ANTIGEN SPECIFICITY

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531805A (zh) * 2015-03-05 2018-01-02 弗雷德哈钦森癌症研究中心 免疫调节融合蛋白及其用途
CN107523547A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抑制性抗体的car‑t细胞及其用途
EP3483182A1 (en) * 2016-07-08 2019-05-15 Carsgen Therapeutics Co., Ltd. Antibody for anti-claudin 18a2 and use thereof
CN109468278A (zh) * 2017-09-08 2019-03-15 科济生物医药（上海）有限公司 基因工程化的t细胞及应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116606884A (zh) * 2023-07-17 2023-08-18 广东赛尔生物科技有限公司 一种制备car-t细胞的方法以及制得的car-t细胞及其应用
CN116606884B (zh) * 2023-07-17 2023-09-29 广东赛尔生物科技有限公司 一种制备car-t细胞的方法以及制得的car-t细胞及其应用
WO2025035746A1 (zh) * 2023-08-15 2025-02-20 福建医科大学附属协和医院 一种靶向b7-h3并共表达细胞因子和趋化因子的car-t细胞及其用途

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