CN115670998A - Acne-removing, oil-controlling and skin-brightening composition and preparation method thereof - Google Patents
Acne-removing, oil-controlling and skin-brightening composition and preparation method thereof Download PDFInfo
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an acne-removing, oil-controlling and skin-brightening composition which comprises the following raw materials in parts by weight: 15-26 parts of sophora flavescens, 20-35 parts of salvia miltiorrhiza, 30-50 parts of salix alba, 15-30 parts of coptis chinensis, 15-20 parts of gentian, 15-20 parts of honeysuckle, 15-20 parts of fructus kochiae, 0.5-4 parts of penetrating agent, 0.3-1 part of PCA zinc, 2-3 parts of potassium azelaidate, 3-5 parts of nicotinamide and 65-75 parts of water. The acne cream can quickly promote the ripening and the acne removal, deeply remove acne thalli, effectively remove the acne and inhibit the breeding of the acne, thereby eradicating the acne, improving acne muscles, controlling oil, improving the water and oil balance of skin, improving the acne printing color deposition, inhibiting the activity of tyrosinase, brightening the skin and recovering the elasticity of the skin.
Description
Technical Field
The invention relates to the technical field of plant compound preparations, in particular to an acne-removing, oil-controlling and skin-brightening composition and a preparation method thereof.
Background
The acne is clinically called as acne, most of the acne is caused by excessive secretion of androgens in the adolescence stage, cutin thickens under the action of androgens, meanwhile, a large amount of sebum is secreted by sebaceous glands to gradually block pores and accumulate continuously, cutin blocking particles are formed and commonly called as comedones, and bacteria continuously nourish in the comedones to form the acne with running sores.
With the development and progress of society, acne breeding is directly or indirectly caused by various reasons such as spicy diet habit, frequent staying up all night, endocrine imbalance, cosmetics allergy disorder, oily skin cleaning inappropriately, pore blocking and the like, and meanwhile, the range of acne muscles is derived from adolescence to adulthood and even middle-age.
Acne can be transmitted if acne and pox can not be effectively inhibited and removed, acne and pox pit can be caused by long-term acne and pox breeding, the face is stiff, and the acne and pox breeding cannot be beautiful and can even cause local skin cancer. Acne removal has been a problem frequently encountered by people because it has seriously affected many people's lives.
At present, a plurality of acne removing products have different degrees of problems, which cause the limited acne removing effect, for example, western medicine hormone acne removing products have stronger tolerance, which causes the acne to be more and more difficult to treat; the acid-brushing acne-removing product is easy to improperly operate, so that the cuticle becomes very thin and even becomes sensitive muscle, acne marks cannot be removed, and more skin problems are caused; the chemical acne removing product has insufficient acne removing strength, can only remove acnes for a short time, cannot eliminate acnes, and is repeated frequently, so that the face is dark and caked, and acne marks and acne pits are generated.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide an acne-removing, oil-controlling and skin-brightening composition and a preparation method thereof. The composition can rapidly promote the maturity of acne, deeply remove acne thallus, effectively remove acne, and inhibit the growth of acne, thereby eradicating acne, improving acne muscle, controlling oil, improving the water and oil balance of skin, improving the color depth of acne, inhibiting tyrosinase activity, brightening skin, and restoring skin elasticity.
In order to achieve the purpose, the invention provides an acne-removing, oil-controlling and skin-brightening composition which comprises the following raw materials in parts by weight: 15-26 parts of radix sophorae flavescentis, 20-35 parts of salvia miltiorrhiza, 30-50 parts of salix alba, 15-30 parts of coptis chinensis, 15-20 parts of gentian, 15-20 parts of honeysuckle, 15-20 parts of fructus kochiae, 0.5-4 parts of penetrating agent, 0.3-1 part of PCA zinc, 2-3 parts of potassium azelaidate, 3-5 parts of nicotinamide and 65-75 parts of water.
Optionally, the penetrating agent is at least one of laurocapram and tetrahydropiperine.
Optionally, the penetrant is 1-2 parts of laurocapram and 0.5-2 parts of tetrahydropiperine.
Optionally, the feed comprises the following raw materials in parts by weight: 20 parts of sophora flavescens, 25 parts of salvia miltiorrhiza, 35 parts of salix alba, 20 parts of coptis chinensis, 18 parts of gentian, 18 parts of honeysuckle, 18 parts of belvedere fruit, 0.5 part of penetrating agent, 0.3 part of PCA zinc, 2 parts of potassium azelaiyl diglycinate, 3 parts of nicotinamide and 74.2 parts of water.
The preparation method of the acne-removing, oil-controlling and skin-brightening composition comprises the following steps:
(1) Weighing the components in parts by weight, mixing and crushing the lightyellow sophora root, the red sage root, the salix alba, the coptis chinensis, the gentian, the honeysuckle and the belvedere fruit to obtain plant composition powder;
(2) Soaking the plant composition powder with propylene glycol, stirring while heating with microwave, and performing constant temperature condensation reflux extraction for 24-48 hr to obtain extract mixture;
(3) Standing the extraction mixture, and filtering the supernatant to obtain an extract as phase A;
(4) Dissolving PCA zinc, potassium azelaioyl diglycine and nicotinamide in water, slowly adding a penetrating agent, stirring and mixing until the materials are completely dissolved to serve as a phase B;
(5) Slowly adding the phase B into the phase A, mixing and stirring, homogenizing, stirring and defoaming to obtain the acne-removing, oil-controlling and skin-brightening composition.
Optionally, the percentage concentration of propylene glycol in step (2) is 100%.
Optionally, the constant temperature in the step (2) is 50-60 ℃.
The pharmacological effects of the raw material components in the composition are as follows:
the sophora flavescens has the effects of balancing grease secretion, dredging and astringing pores, promoting the growth and repair of damaged vascular nerve cells, recovering the activity of subcutaneous capillary cells, enabling skin to be compact and smooth and playing a role in beautifying and protecting skin.
Red sage root: detumescence and pain relieving, blood circulation promoting and menstruation promoting, blood stasis dispelling and pain relieving, blood cooling and carbuncle eliminating.
White willow: the white willow extract is rich in salicin and has good antibacterial and pox removing effects.
Coptis chinensis: clearing heat and drying dampness, purging fire and removing toxicity, externally treating eczema, eczema and running sore, and having certain antifungal, anti-inflammatory and antioxidant effects.
Gentian: gentiana scabra Bunge is one of 5 Tibetan medicines, and has good effects of relieving pain and itching, inhibiting bacteria and diminishing inflammation, and scavenging free radicals
Honeysuckle flower: clearing away heat and toxic materials, treating sore and suppuration, inhibiting bacteria, resisting virus, relieving inflammation, relieving fever, and regulating immunity
Kochiae fructus has effects of clearing heat, promoting diuresis, dispelling pathogenic wind and relieving itching; can be used for treating and improving red swelling of skin and allergic dermatitis.
Zinc PCA: controlling oil, resisting inflammation, and inhibiting excessive sebum secretion.
Potassium nonanedioyl diglycinate: the derivative of azelaic acid effectively inherits the effects of azelaic acid in inhibiting tyrosinase activity and melanin generation, reduces irritation, can effectively inhibit acne mark generation and can fade the generated acne mark.
Nicotinamide: accelerating the metabolism of skin stratum corneum and improving skin resistance. Has good effects of improving the formula roughness, repairing the horny layer and strengthening the self defense capability of the skin.
The application has the following beneficial effects:
(1) The low-irritation plant is selected as the main acne-removing raw material, and the active ingredients of the plant are efficiently extracted by adopting a microwave heating extraction method.
(2) The penetrant with low irritation is matched with the active ingredients, so that the active ingredients can easily permeate the skin cuticle, are easier to absorb and utilize, and are convenient for exerting the effect.
(3) The composition is mild, fine and smooth, has good skin-adhering property, and is easy to be applied and absorbed.
(4) The coptis, the honeysuckle and the belvedere fruit are compounded for clearing heat and cooling blood, purging intense heat and detoxifying, maintaining endocrine balance and providing an environment which is not beneficial to the growth of pox from the source; the salvia miltiorrhiza is used for activating blood and stimulating the menstrual flow, the renewal of cuticle is accelerated, the cutin is prevented from thickening, and meanwhile, the sophora flavescens balances grease secretion, dredges pores and prevents the cutin from blocking particles; the felwort and the salix alba are compounded to relieve pain and itching, resist inflammation and inhibit bacteria, so that the problem of inflammation of skin caused by bacterial infection and grease degradation is prevented; the acne caused by various mechanisms is treated in a targeted manner, the problems of acnes and pockmarks are solved in multiple angles and multiple aspects, and pain of patients is improved.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention as claimed is not limited to the examples.
Example schemes and Processes
The acne-removing, oil-controlling and skin-brightening composition is characterized by comprising the following raw materials in parts by weight: 15-26 parts of radix sophorae flavescentis, 20-35 parts of salvia miltiorrhiza, 30-50 parts of salix alba, 15-30 parts of coptis chinensis, 15-20 parts of gentian, 15-20 parts of honeysuckle, 15-20 parts of fructus kochiae, 0.5-4 parts of penetrating agent, 0.3-1 part of PCA zinc, 2-3 parts of potassium azelaidate, 3-5 parts of nicotinamide and 65-75 parts of water.
The preparation method of the acne-removing, oil-controlling and skin-brightening composition comprises the following steps:
(1) Weighing the components in parts by weight, mixing and crushing the lightyellow sophora root, the red sage root, the white willow, the coptis root, the gentian, the honeysuckle and the belvedere fruit to obtain plant composition powder;
(2) Soaking the plant composition powder with 100% propylene glycol, stirring while heating with microwave, and condensing and reflux-extracting at 55 + -2 deg.C for 24 hr to obtain extract mixture;
(3) Standing the extraction mixture, and filtering the supernatant to obtain an extract as phase A;
(4) Dissolving PCA zinc, potassium azelaioyl diglycine and nicotinamide in water, slowly adding a penetrating agent, stirring and mixing until the materials are completely dissolved to serve as a phase B;
(5) Slowly adding the phase B into the phase A, mixing and stirring, homogenizing, stirring and defoaming to obtain the acne-removing, oil-controlling and skin-brightening composition.
Examples 1 to 6
The ratio of the raw materials in the acne-removing, oil-controlling and skin-brightening composition is as follows:
table 1: raw material table (/ parts) of extract in compositions of different examples
| Components | Extract A | Extract B | Extract C |
| Sophora flavescens ait | 15 | 20 | 26 |
| Root of red-rooted salvia | 20 | 25 | 35 |
| White willow | 30 | 35 | 50 |
| Coptis chinensis | 15 | 20 | 30 |
| Radix Gentianae | 15 | 18 | 20 |
| Honeysuckle | 15 | 18 | 20 |
| Kochia scoparia (L.) Schrad | 15 | 18 | 20 |
| Propylene glycol | 200 | 200 | 200 |
The refractive index, active matter content and medicine residue residual quantity of the extract A, B, C are measured, and the following data are obtained:
table 2: test data for different extracts
| Item | Extract A | Extract B | Extract C |
| Refractive index | 1.411 | 1.394 | 1.382 |
| Weight of extract | 100g | 100g | 100g |
| Solid content of extract | 0.73g | 1.02g | 1.33g |
| Active content | 1.87％ | 2.03％ | 2.63％ |
| Dosage of medicine | 125g | 154g | 201g |
| Extraction rate | 1.50％ | 1.38％ | 1.31％ |
The test methods are as follows:
(1) Refractive index: the deeper the color and luster of the same proportion is, the better the extraction effect is when the refractometer is used for detection.
(2) And (3) calculating the content of active substances: and (3) taking the weight M of the extract, baking the extract at 200 ℃ for 4 hours to obtain the weight M2 of the solid, and calculating the formula M2/M = the content of the active substances.
(3) Extraction rate: adding plant composition total weight M, and baking the residue obtained after extraction at 200 deg.C for 4 hr to obtain residue M1 without water and ethanol residue, (M-M1)/M = extraction rate.
As can be seen from Table 2, the extract liquid obtained in the present invention can efficiently extract the active plant of the plant composition while maintaining the activity of the plant composition.
Table 3: raw material tables of different examples
Extracts A to C were prepared according to the data in Table 1 and the preparation steps (1) to (3) of the examples, respectively; the acne-removing, oil-controlling and skin-brightening compositions of examples 1-6 were prepared according to the data in table 3 and the preparation steps (4) - (5) of example 1, respectively.
As can be seen from Table 3, the Chinese medicinal extract liquid prepared by the method not only can maintain the activity of the Chinese medicament, but also can efficiently extract the active substances of the Chinese medicament. Examples 3 and 6 achieved higher extraction rates, indicating that the higher the alcohol concentration content, the higher the extraction rate; if the later-stage medicine application is the high-concentration Chinese medicine liquid, the method of example 3 is selected, and if the later-stage medicine application is the low-concentration Chinese medicine liquid, the method of example 6 is selected as the optimal extraction mode.
Test items
And (3) irritation test: the anti-acne plant composition prepared in examples 1-6 is subjected to spot application experiments, and equal amount of samples are respectively taken to carry out single and multiple administrations on the back skin of the same person, and the skin irritation changes are observed after 30 minutes, 1 hour, 4 hours, 8 hours, 12 hours and 24 hours.
Absorption speed: the skin was removed, and the skin was divided into 1cm × 1cm, dosed in equal amounts in multiple zones and the time to complete absorption was recorded.
Transdermal force: after the pigskin is completely absorbed by administration, slices are taken for 10 minutes, 30 minutes, 1 hour and 3 hours, and the penetration depth is observed as a transdermal force test.
And (3) acne removal test: samples from examples 1-6 were tested on 90 vaccinia muscle populations. Among them, 30 adolescent subjects aged 15-22 years, men and women, are mostly acne caused by hormone or endocrine disturbance. 30 women aged 35-45 years old who habitually had menstrual-long pox. 30 office workers with the age of 30-40 years old, men and women are half, and because of irregular life and work, the situation of acne growing often appears when the office workers stay working overnight.
Data comparison
Table 4: comparison of data from different examples
| Test items | Irritation property | Absorption rate | Degree of penetration |
| Example 1 | ++ | ++ | ++ |
| Example 2 | ++ | ++ | ++ |
| Example 3 | ++ | ++ | ++ |
| Example 4 | + | ++ | +++ |
| Example 5 | + | ++ | +++ |
| Example 6 | + | ++ | +++ |
Comparing the data in Table 4, the irritation analysis can be used to obtain the preferred recipe of example 4, example 5, and example 6; the absorption speed is analyzed, so that the two penetrants have the same influence on the absorption speed; the preferred formulation for the comparative skin penetration results are example 4, example 5, example 6.
Acne removal test: the 90 subjects were divided into 6 groups of 15 persons each, and facial pox areas were selected corresponding to the compositions of examples 1 to 6, smeared 2 times a day, observed for the immediate acne-removing ability for 1 to 5 days, and the recurrence of pox on day 10 and 20 days.
Table 5: acne removal data for different examples (number of people)
| Test items | Effective for 1 day | Effective for 3 days | Effective for 5 days | Recurrence in 10 days | Recurrence after 20 days |
| Example 1 | 9 | 11 | 12 | 2 | 2 |
| Example 2 | 11 | 13 | 14 | 1 | 1 |
| Example 3 | 12 | 13 | 14 | 1 | 1 |
| Example 4 | 10 | 12 | 13 | 1 | 2 |
| Example 5 | 12 | 14 | 15 | 0 | 1 |
| Example 6 | 12 | 14 | 15 | 0 | 1 |
The evaluation criteria of the curative effect are as follows:
the method has the following advantages: the acne becomes small, the red and swollen are eliminated, and the pain and the itch are obviously relieved.
And (4) invalidation: the signs of symptoms were not significantly changed compared to before treatment.
As can be seen from table 5, the optimal acne removal regimens are example 5 and example 6.
The acne mark remaining condition of each group of examples after the removal of the acne was observed to evaluate the inhibition effect of the composition on the acne mark, and the following data were obtained:
table 6: acne mark data (number of people) of different examples
Table 6 analysis of data: the composition of the invention has good effect of inhibiting the generation of the acne marks.
The improvement of the smoothness of the skin after acne removal of each group of examples is observed to evaluate the repair effect of the composition on the skin, and the following data are obtained:
table 7: data (number of people) for improving skin smoothness in different embodiments
| Test item | Effective improvement in 7 days | Is effective for 14 days | Effective improvement in 28 days |
| Example 1 | 4 | 10 | 14 |
| Example 2 | 3 | 10 | 15 |
| Example 3 | 5 | 10 | 14 |
| Example 4 | 6 | 11 | 15 |
| Example 5 | 7 | 13 | 15 |
| Example 6 | 7 | 13 | 15 |
Table 7 data analysis: the composition of the present invention is effective for improving the smoothness of the skin.
The improvement effect of each group of examples on the existing pox marks and the skin lightening color after pox removal is observed, and the following data are obtained:
table 8: different examples improve data (number of people) for improving acne marks and skin brightness
| Test items | Effective improvement in 7 days | Is effective for 14 days | Effective improvement in 28 days |
| Example 1 | 4 | 11 | 14 |
| Example 2 | 3 | 11 | 12 |
| Example 3 | 5 | 12 | 14 |
| Example 4 | 4 | 13 | 15 |
| Example 5 | 5 | 13 | 15 |
| Example 6 | 3 | 12 | 15 |
Table 8 data analysis: the composition has obvious effects of brightening skin, improving color fastness and removing acne marks.
The data and analysis results in tables 1-8 are integrated, and the optimized acne-removing, oil-controlling and skin-brightening composition and the preparation method thereof are obtained by combining the use of material cost performance, and the composition is shown in example 5.
The above description is only a preferred embodiment of the present invention, and the scope of the present invention is not limited to the above embodiments, and all technical solutions that belong to the idea of the present invention belong to the scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (7)
1. The acne-removing, oil-controlling and skin-brightening composition is characterized by comprising the following raw materials in parts by weight: 15-26 parts of radix sophorae flavescentis, 20-35 parts of salvia miltiorrhiza, 30-50 parts of salix alba, 15-30 parts of coptis chinensis, 15-20 parts of gentian, 15-20 parts of honeysuckle, 15-20 parts of fructus kochiae, 0.5-4 parts of penetrating agent, 0.3-1 part of PCA zinc, 2-3 parts of potassium azelaidate, 3-5 parts of nicotinamide and 65-75 parts of water.
2. The composition for removing acne, controlling oil and brightening skin according to claim 1, wherein the penetrating agent is at least one of laurocapram and tetrahydropiperine.
3. The composition for removing acne, controlling oil and brightening skin according to claim 1, wherein the penetrating agent is 1-2 parts of laurocapram and 0.5-2 parts of tetrahydropiperine.
4. The composition for removing acne, controlling oil and brightening skin according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 20 parts of lightyellow sophora root, 25 parts of salvia miltiorrhiza, 35 parts of white willow, 20 parts of coptis chinensis, 18 parts of gentian, 18 parts of honeysuckle, 18 parts of belvedere fruit, 0.5 part of penetrating agent, 0.3 part of PCA zinc, 2 parts of potassium azelaianoyl diglycinate, 3 parts of nicotinamide and 74.2 parts of water.
5. A method for preparing the composition for removing acne, controlling oil and brightening skin according to any one of claims 1 to 4, which comprises the following steps:
(1) Weighing the components in parts by weight, mixing and crushing the lightyellow sophora root, the red sage root, the salix alba, the coptis chinensis, the gentian, the honeysuckle and the belvedere fruit to obtain plant composition powder;
(2) Soaking the plant composition powder with propylene glycol, stirring while heating with microwave, and performing constant temperature condensation reflux extraction for 24-48 hr to obtain extract mixture;
(3) Standing the extraction mixture, and filtering the supernatant to obtain an extract as phase A;
(4) Dissolving PCA zinc, potassium azelaioyl diglycine and nicotinamide in water, slowly adding a penetrating agent, stirring and mixing until the materials are completely dissolved to serve as a phase B;
(5) Slowly adding the phase B into the phase A, mixing and stirring, homogenizing, stirring and defoaming to obtain the acne-removing, oil-controlling and skin-brightening composition.
6. The preparation method of the composition for removing acne, controlling oil and brightening skin according to claim 5, characterized in that the percentage concentration of propylene glycol in step (2) is 100%.
7. The preparation method of the composition for removing acne, controlling oil and brightening skin according to claim 5, wherein the constant temperature in the step (2) is 50-60 ℃.
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