CN115970155B - Metal substrate electrode, tumor electric field treatment electrode and system - Google Patents
Metal substrate electrode, tumor electric field treatment electrode and system Download PDFInfo
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- CN115970155B CN115970155B CN202310284480.8A CN202310284480A CN115970155B CN 115970155 B CN115970155 B CN 115970155B CN 202310284480 A CN202310284480 A CN 202310284480A CN 115970155 B CN115970155 B CN 115970155B
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 239000000919 ceramic Substances 0.000 claims description 6
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Abstract
The invention provides a metal substrate electrode, which comprises a copper-clad circuit layer, a first insulating layer arranged at the lower end of the copper-clad circuit layer, a metal substrate arranged at the lower end of the first insulating layer, wherein the copper-clad circuit layer is provided with a first copper-clad circuit layer, a second copper-clad circuit layer and a third copper-clad circuit layer, the first copper-clad circuit layer is used for connecting an electrode, the second copper-clad circuit layer and the third copper-clad circuit layer are used for connecting a temperature sensor, and a solder mask layer is arranged above the copper-clad circuit layer. Above-mentioned metal substrate electrode, metal substrate self can form the dense oxide layer of one deck in the air, can play fine insulating effect and heat conduction, effectually avoided scalding user's skin, metal substrate and can realize self-repairing function after sharp instrument is damaged, because metal substrate, first insulating layer's thermal resistance is all very little, can directly put temperature sensor in copper circuit layer and need not the sunken skin design of pressing close to, the uniformity is better.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a metal substrate electrode, a tumor electric field treatment electrode and a tumor electric field treatment system.
Background
The english name of tumor electric field therapy is Tumor Treating Fields, and the english abbreviation is TTF. Is initially used for treating malignant glioma. Tumor electric field therapy in 2019 was approved for the treatment of malignant pleural mesothelioma. The trade names are not very the same, but slightly different in length depending on the treatment site.
The existing tumor electric field treatment device can cause micro-current due to the fact that an electric field directly acts on human tissues, the micro-current can cause a thermal effect, and meanwhile discomfort and skin scalding risks are brought to a human body.
Disclosure of Invention
The invention aims to provide a tumor electric field treatment system so as to solve the problem that the existing tumor electric field treatment device has the risk of scalding skin.
The invention provides a metal substrate electrode, which comprises a copper-clad circuit layer, a first insulating layer arranged at the lower end of the copper-clad circuit layer and a metal substrate arranged at the lower end of the first insulating layer, wherein the copper-clad circuit layer is provided with a first copper-clad circuit layer, a second copper-clad circuit layer and a third copper-clad circuit layer, the first copper-clad circuit layer is used for connecting an electrode, the second copper-clad circuit layer and the third copper-clad circuit layer are used for connecting a temperature sensor, and a solder mask layer is arranged above the copper-clad circuit layer.
Above-mentioned metal substrate electrode, metal substrate self can form one deck compact metal oxide layer in the air, can play fine insulating effect and heat conduction, effectually avoided scalding user's skin, metal substrate and can realize self-repairing function after sharp instrument is damaged, because metal substrate, first insulating layer's thermal resistance is all very little, can directly put temperature sensor in copper circuit layer and need not the sunken skin design of pressing close to, the uniformity is better.
Further, the metal substrate electrode further comprises a second insulating layer and a conducting layer, wherein the second insulating layer is located below the metal substrate, and the conducting layer is located below the second insulating layer.
Further, the metal substrate electrode is in contact with the skin through the conductive gel.
Further, the thickness of the conductive gel is 0.1-5mm.
Further, the tail end of the copper-clad circuit layer is provided with a wiring terminal, the electrode wire and the temperature sensor are connected with the copper-clad circuit layer through the wiring terminal,
further, an insulating potting layer is arranged on the periphery of the wiring terminal and the solder mask layer.
Further, the wiring terminal is a bonding pad or a socket.
Further, the surface of the metal substrate electrode is provided with an air-permeable adhesive tape.
Further, the area of the lower surface of the metal substrate electrode is not more than 50cm 2 。
Further, the first insulating layer comprises epoxy glue and ceramic powder, and the mass ratio of the epoxy glue to the ceramic powder is 1:1-10:1.
Further, the metal substrate is one of an aluminum substrate, a copper substrate and an iron substrate.
The invention also provides a tumor electric field treatment electrode, which comprises a first electrode and a second electrode which are respectively formed by at least two metal substrate electrodes, wherein the first electrode and the second electrode form a pair of electrodes, the first electrode is connected with a first electrode wire, and the second electrode is connected with a second electrode wire.
The invention also provides a tumor electric field treatment system, which comprises a human-computer interaction interface, a control unit, a power supply unit, a voltage amplitude adjusting circuit, an inversion frequency modulation circuit and a signal distribution circuit, and further comprises tumor electric field treatment electrodes.
Further, the number of the tumor electric field treatment electrodes is multiple, and the signal distribution circuit distributes the tumor electric field treatment electrodes in a time-sharing way;
the temperature sensor on the tumor electric field treatment electrode is connected with the control unit;
the control unit is used for controlling the power supply unit, the voltage amplitude regulating circuit, the inversion frequency modulation circuit, the signal distribution circuit and the tumor electric field treatment electrode;
the power supply unit is used for supplying power to the tumor electric field treatment system;
the voltage amplitude regulating circuit, the inversion frequency modulation circuit and the signal distribution circuit are sequentially connected in series;
the tumor electric field treatment system sets control parameters through a human-computer interaction interface, and the control unit controls and modulates the output voltage of the power supply unit, the output voltage of the voltage amplitude regulating circuit, the output frequency of the inversion frequency modulation circuit and the scanning period of the signal distribution circuit to enable the control parameters to be reached, so that the temperature of the tumor electric field treatment electrode is monitored, early-warned and protected.
Further, the first electrode and the second electrode respectively comprise a plurality of metal substrate electrodes with the same number, the plurality of metal substrate electrodes are arranged in an array, and two adjacent metal substrate electrodes are connected with each other.
Drawings
FIG. 1-1 is a schematic diagram of a metal substrate electrode according to an embodiment of the invention;
FIGS. 1-2 are schematic diagrams illustrating structures of metal substrate electrodes according to further embodiments of the present invention;
FIG. 2 is a schematic diagram of an embodiment of an electric field tumor therapy electrode according to the present invention;
FIG. 3 is a schematic diagram of a tumor electric field therapy system according to an embodiment of the invention;
FIG. 4 is a schematic diagram showing the connection structure of the control unit, the signal distribution circuit and the metal substrate electrode in the tumor electric field treatment system of FIG. 3;
FIG. 5 is a schematic diagram showing the connection structure of the control unit, the signal distribution circuit and the metal substrate electrode in the tumor electric field treatment system according to an embodiment of the present invention;
fig. 6 is a schematic diagram of a connection structure of a control unit, a signal distribution circuit and a metal substrate electrode in a tumor electric field treatment system according to an embodiment of the invention.
Fig. 7 is an equivalent circuit diagram of a tumor electric field therapy system according to an embodiment of the invention.
Fig. 8 is an equivalent circuit diagram of a tumor electric field therapy system according to still another embodiment of the present invention.
Description of main reference numerals:
| copper-clad circuit layer | 10 | Connecting terminal | 60 | Swelling based on metal substrate electrode Tumor electric field treatment system | 300 |
| Conductive via | 11 | Insulating potting layer | 80 | Control unit | 301 |
| Mounting hole | 12 | Breathable adhesive tape | 90 | Power supply unit | 302 |
| A first insulating layer | 20 | Metal substrate electrode | 100 | Voltage amplitude regulating circuit | 303 |
| Metal substrate | 30 | Based on electrodes of a metal substrate Tumor electric field treatment electrode | 200 | Inversion frequency modulation circuit | 304 |
| Conductive gel | 40 | First pole connecting wire | 201 | Signal distribution circuit | 305 |
| Temperature sensor | 50 | Second pole connecting wire | 202 | Human-computer interaction interface | 306 |
| Second insulating layer | 2 | Conductive layer | 3 |
The invention will be further described in the following detailed description in conjunction with the above-described figures.
Description of the embodiments
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Several embodiments of the invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "mounted" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1-1, a metal substrate electrode 100 according to an embodiment of the present invention includes a copper-clad circuit layer 10, a first insulating layer 20 disposed at a lower end of the copper-clad circuit layer 10, a metal substrate 30 disposed at a lower end of the first insulating layer 20, a conductive gel 40 disposed at a lower end of the metal substrate 30, and a temperature sensor disposed above the copper-clad circuit layer 10.
It will be appreciated that the copper-clad circuit layer 10 has a first, a second and a third copper-clad circuit layers, the first copper-clad circuit layer is used for connecting electrodes, the second and the third copper-clad circuit layers are respectively used for connecting one end and the other end of the temperature sensor, and a solder resist layer is arranged on the surface of the copper-clad circuit layer 10.
Specifically, the terminal ends of the first, second and third copper-clad circuit layers are respectively provided with a wiring terminal 60, and the electrode and the temperature sensor are connected with the corresponding copper-clad circuit layers through the wiring terminals.
Preferably, after the electrode wire and the temperature sensor are connected, an insulating encapsulating layer is arranged at the periphery of the wiring terminal 60 and the solder mask layer, and is used for encapsulating all the connection part of the electrode wire and the first copper-clad circuit layer, the wiring terminal 60, the solder mask layer and the temperature sensor, so as to realize the protection functions of fixation, insulation, water resistance, moisture resistance, dust resistance and the like, and the insulating encapsulating layer can be formed by encapsulating epoxy, silica gel or other materials.
It will be appreciated that the connection terminals are pads or sockets, for example, in one case, the connection terminals 60 at the ends of the first, second and third copper-clad circuit layers are pads, and at this time, one end of the connection wire is welded to the pad at the end of the first copper-clad circuit layer, and two ends of the temperature sensor are respectively welded to the pads at the ends of the second and third copper-clad circuit layers; in another case, the terminal 60 at the end of the first copper-clad circuit layer is a bonding pad, the terminal 60 at the end of the second copper-clad circuit layer and the terminal 60 at the end of the third copper-clad circuit layer are sockets, at this time, one end of the connecting wire is welded at the bonding pad at the end of the first copper-clad circuit layer, and two ends of the temperature sensor are respectively spliced on the sockets at the ends of the second copper-clad circuit layer and the third copper-clad circuit layer; the form of the connection terminals is not specifically mentioned here, as long as the connection terminals can be adapted to the connection lines and the temperature sensor.
It is understood that the metal substrate 30 may be any one of an aluminum substrate, a copper substrate, an iron substrate, or other metal substrate. The aluminum substrate has good heat dissipation performance and relatively low price; the heat dissipation performance of the copper substrate is better than that of the aluminum substrate, but the price is more expensive; the iron substrate has the lowest price and poor heat dissipation performance, but is easier to oxidize to form an oxidation insulating layer.
The metal substrate electrode itself forms a dense metal oxide layer in air (for example, when the metal substrate is an aluminum substrate, the metal oxide layer is Al 2 O 3 ) In use, the metal substrate 30 can play a good role in insulation and heat conduction, effectively avoid scalding the skin of a user, and realize a self-repairing function after the sharp tool is damaged; in addition, the metal substrate 30, the first insulating layer 20 and the conductive gel 40 have very small thermal resistance, so that the temperature sensor can be directly placed on the surface of the electrode of the metal substrate without sinking to be close to the skin, and the consistency is better.
Note that the conductive gel 40 may be omitted; when the conductive gel 40 is not present, the lower surface of the metal substrate 30 is in contact with the skin during the treatment, and when the conductive gel 40 is used, the conductive gel 40 is in direct contact with the skin, and the conductive gel has a modulus similar to that of the skin, so that the skin tolerance can be ensured.
The thickness of the conductive gel 40 may be selected according to practical needs, and in one embodiment, the thickness of the conductive gel is 0.1-5mm.
In one embodiment of the present invention, the metal substrate electrode surface is provided with a gas permeable adhesive tape 90 so as to fix the metal substrate electrode 100 on the surface of the human body, more specifically, the upper surface of the metal substrate electrode 100 is attached to the gas permeable adhesive tape 90 so that the lower surface of the metal substrate electrode 100 is in contact/attached fixation with the surface of the human body.
In one embodiment of the present invention, the maximum area of the lower surface of the single metal substrate electrode 100 is not more than 50cm 2 Because of poor skin flatness, the area of the single metal substrate electrode 100 should not be too large, so that the single metal substrate electrode can be in close contact with the skin; the shape of the metal substrate electrode 100 may be customized according to the tumor location and size of the patient, and may be circular, square, polygonal, or irregular.
In one embodiment of the present invention, the first insulating layer 20 includes epoxy paste and ceramic powder to perform an insulating function. In one embodiment, the mass ratio of the epoxy glue to the ceramic powder is 1:1-10:1.
In one embodiment of the present invention, the dielectric constant of the first insulating layer 20 is relatively high, the insulating property is good, and the thickness can be relatively small, which can be achieved by spraying an insulating paint or attaching an insulating film.
In one embodiment of the invention, the temperature sensor is a thermistor to realize the temperature detection function, but when the temperature is detected to be too high (for example, the temperature is over 40 degrees), discomfort of a human body or damage to skin can be caused, the system gives out an over-temperature alarm and stops for heat dissipation and cooling, and the system is restarted after the temperature is reduced to a certain degree.
Referring to fig. 1-2, a metal substrate electrode 100 according to still another embodiment of the present invention is provided, and compared with the embodiment shown in fig. 1-2, the embodiment further includes a second insulating layer 2 and a conductive layer 3, the second insulating layer 2 and the conductive layer 3 are located between the metal substrate 30 and the conductive gel 40, wherein the second insulating layer 2 is located below the metal substrate 30, and the conductive layer 3 is located below the second insulating layer 2 and above the conductive gel 40; the advantages of this arrangement are: the second insulating layer 2 can better prevent the surface layer of the metal substrate 30 from oxidizing, and in order to realize that the electric field transmits energy in a capacitive manner, one conductive layer 3 is added, so that the metal substrate 30, the second insulating layer 2 and the conductive layer 3 form another capacitive structure (capacitor).
In the embodiment shown in fig. 1-2, wherein the conductive layer 3 may be a metal substrate, the conductive gel 40 may be omitted; when the conductive gel 40 is not used, the lower surface of the conductive layer 3 is in contact with the skin in the treatment process, and when the conductive gel 40 is used, the conductive gel 40 is in direct contact with the skin, and the conductive gel has a modulus similar to that of the skin, so that the conductive gel can be in contact with the surface of the skin more fully, and meanwhile, the tolerance of the skin is ensured.
Preferably, the second insulating layer 2 is a metal oxide insulating layer; preferably, the thickness of the second insulating layer 2 is 0.01-10 μm, and the thickness of the conductive gel can be controlled by passivation or other processes.
It will be appreciated that the second insulating layer 2 may also cover the sides of the metal substrate 30 at the same time to achieve better insulation.
Referring to fig. 2, the embodiment of the present invention further provides a tumor electric field treatment electrode 200, which is formed by at least two metal substrate electrodes 100 respectively, wherein the first electrode (positive electrode) and the second electrode (negative electrode) form a pair of electrodes, the first electrode is connected with a first electrode wire 201, and the second electrode is connected with a second electrode wire 202.
It will be appreciated that, in addition to the first electrode and the second electrode each including one metal substrate electrode, in some embodiments, the first electrode and the second electrode may each include the same number of multiple metal substrate electrodes, where multiple metal substrate electrode arrays belonging to the same electrode are disposed and all connected to the same electrode line, for example, two adjacent metal substrate electrodes are connected to each other and then connected to the first electrode line/the second electrode line; for example, in fig. 5, the first electrode and the second electrode each include 2 metal substrate electrodes, and in fig. 6, one electrode includes 9 metal substrate electrodes; in the arrangement of the number of the metal substrate electrodes in the first electrode and the second electrode, the arrangement may be according to actual needs, for example, when the tumor is large, a larger number of metal substrate electrodes may be used, conversely, when the tumor is small, a smaller number of metal substrate electrodes may be arranged, and so on.
In addition, in the tumor electric field treatment electrode 200, the metal substrate 30 itself can form a compact metal oxide layer in the air, which can play a good role in insulation and heat conduction, effectively avoid scalding the skin of a user, and simultaneously the metal substrate 30 can realize a self-repairing function after the sharp instrument is damaged, and because the thermal resistances of the metal substrate 30 and the first insulation layer 20 are very small, the temperature sensor can be directly placed on the surface of the metal substrate electrode 100 without sinking to be close to the skin, and the consistency is better.
Referring to fig. 3, the embodiment of the present invention further provides a tumor electric field treatment system 300, which includes a control unit 301, a power supply unit 302, a voltage amplitude adjustment circuit 303, an inverse frequency modulation circuit 304, and a signal distribution circuit 305, and further includes at least one tumor electric field treatment electrode 200 as described above, where each signal distribution circuit 304 is connected to one tumor electric field treatment electrode 200 respectively;
the tumor electric field treatment electrode 200 is also connected with the control unit 301;
the control unit 301 is configured to control the power supply unit 302, the voltage amplitude adjustment circuit 303, the inverse frequency modulation circuit 304, the signal distribution circuit 305, and the tumor electric field treatment electrode;
the power supply unit 302 is configured to supply power to the tumor electric field treatment system, for example, an output end of the power supply unit 302 is direct current, and the power supply unit 302 supplies power to the voltage amplitude adjusting circuit 303, the control unit 301, and the human-computer interaction interface 306; the voltage amplitude adjusting circuit 303 adjusts the voltage and/or amplitude of the direct current obtained from the power supply unit 302, outputs the adjusted direct current to the inverse frequency modulation circuit 304, the inverse frequency modulation circuit 304 converts the received direct current into alternating current and modulates the frequency (changes the frequency), the alternating current after inversion and frequency modulation is connected to the tumor electric field treatment electrodes 200 through the signal distribution circuit 305, and each tumor electric field treatment electrode 200 has a pair of electrodes; when there are multiple tumor electric field therapy electrodes, the signal distribution circuit 304 performs time-sharing distribution on the multiple tumor electric field therapy electrodes, that is, the signal distribution circuit 304 performs time-sharing alternating energization on multiple pairs of electrodes, for example, a first pair of electrodes is energized in a first period, a second pair of electrodes is energized in a second period, and so on.
The man-machine interface 306 may be used to set control parameters (such as voltage, frequency, scanning period, and temperature threshold), and the control unit 301 controls and modulates the output voltage of the power supply unit 302, the output voltage of the voltage amplitude adjusting circuit 303, the output frequency of the inverse frequency modulation circuit 304, the scanning period of the signal distribution circuit 305, etc. so as to achieve the control parameters, and monitor, early warn, and protect the temperature of the tumor electric field treatment electrode.
The voltage amplitude adjusting circuit 303, the inverse frequency modulation circuit 304 and the signal distribution circuit 305 are sequentially connected in series.
Specifically, the two ends of the temperature sensor are connected to the control unit 301, and the control unit 301 obtains the temperature of the metal substrate electrode 100 according to the change of the temperature sensor, and performs corresponding control.
The control unit 301 may be a PLC controller, and the PLC controller is provided with a man-machine interaction interface 306, so as to manually control the operation parameters of each component.
According to the tumor electric field treatment system 300, the metal substrate 30 can form a compact oxide layer in the air, so that a good insulating effect and a good heat conduction effect can be achieved, the user skin is effectively prevented from being scalded, meanwhile, the metal substrate 30 can realize a self-repairing function after the sharp instrument is damaged, and as the thermal resistances of the metal substrate 30 and the first insulating layer 20 are very small, the temperature sensor can be directly placed on the upper surface of the electrode 100 of the metal substrate without sinking to be close to the skin, and the consistency is better.
In the embodiment of the present invention, the power supply unit 302 may be a built-in battery or an external adapter (ac/dc adapter) connected to a mains supply.
In the embodiment of the present invention, the signal distribution circuit 305 is consistent with the number of the tumor electric field treatment electrodes 200, so as to realize separate control of each tumor electric field treatment electrode, and further realize different output powers of the tumor electric field treatment electrodes at different positions.
In the embodiment shown in fig. 4, one tumor electric field treatment electrode 200 is provided in the embodiment, and the one tumor electric field treatment electrode 200 includes two metal substrate electrodes 100, where the two metal substrate electrodes 100 respectively form a first electrode (positive electrode) and a second electrode (negative electrode).
Referring to fig. 3 and 5, in another embodiment of the tumor electric field treatment system 300 provided by the present invention, one tumor electric field treatment electrode 200 is provided, and the one tumor electric field treatment electrode 200 includes 4 metal substrate electrodes 100, wherein first electrodes of two metal substrate electrodes 100 are connected together to form a positive electrode of the tumor electric field treatment electrode 200, and second electrode ends of the other two metal substrate electrodes 100 are connected together to form a negative electrode of the tumor electric field treatment electrode 200. The metal substrate 30 in the tumor electric field treatment electrode 200 can form a compact metal oxide layer in the air, so that the metal substrate can play a good role in insulation and heat conduction, the skin of a user is effectively prevented from being scalded, meanwhile, the metal substrate 30 can realize a self-repairing function after a sharp tool is damaged, and as the thermal resistances of the metal substrate 30 and the first insulation 20 layer are very small, a temperature sensor can be directly placed on the upper surface of the metal substrate electrode 100 without sinking to be close to the skin, and the consistency is better.
Referring to fig. 3 and 6, in another embodiment of the tumor electric field treatment system 300 based on metal substrate electrodes provided by the present invention, nine metal substrate electrodes 100 corresponding to the positive electrode and the negative electrode of the one tumor electric field treatment electrode 200 are provided, and only the metal substrate electrode 100 corresponding to the positive electrode (+) is shown in fig. 6, and the metal substrate electrode 100 corresponding to the negative electrode (-) is the same; nine metal substrate electrodes 100 are arranged in an array, and electrode ends of adjacent metal substrate electrodes 100 are connected with each other to form a redundant structure, so that even if one of the metal substrate electrodes 100 is disconnected, electrode ends of other metal substrate electrodes 100 are still connected with each other; it will be appreciated that the connection between the metal substrate electrodes 100 may be other connection means besides fig. 6, for example, the electrode terminal of each metal substrate electrode 100 is connected to the electrode terminal of the other metal substrate adjacent thereto, or the electrode terminal of each metal substrate electrode 100 is directly connected to the electrode wire, etc., as long as the connection between the electrode terminal of each metal substrate electrode 100 and the electrode wire can be achieved finally.
It will be appreciated that in order to increase the effect and avoid poor contact of the individual metal substrate electrodes 100, an array structure may be employed, each array comprises a plurality of metal substrate electrodes 100 (for example, in fig. 6, one array comprises 9 metal substrate electrodes 100; in fig. 5, one array comprises 2 metal substrate electrodes 100), the electrode ends of the metal substrate electrodes 100 in each array are connected together to form a redundant structure, the number and shape of the metal substrate electrodes 100 in each array can be customized according to the tumor position and size of the patient, a certain gap is provided between the metal substrate electrodes in each array for ventilation, and a temperature sensor, that is, a thermistor 50 is placed on the upper surface of the metal substrate electrode 100 for detecting skin temperature and preventing skin damage due to excessive temperature. The redundant array formed by the metal substrate electrodes 100 can avoid the failure of the metal substrate electrodes 100 caused by the wire desoldering or the circuit breaking at a certain place, the array formed by the metal substrate electrodes 100 is fixed at the skin of the body surface of a patient through the external air-permeable adhesive tape 90, and the skin contact allergy can be avoided by periodically replacing and cleaning the surface of the array. Wherein, both ends of each metal substrate electrode 100 connected with the temperature controller are connected to the control unit 301, and the electrode of the positive electrode metal substrate electrode 100 on each positive electrode array is connected to the first electrode wire of the signal distribution circuit 305; the negative electrode metal substrate electrodes 100 on each negative electrode array are connected in series with each other and then connected to the second electrode line of the signal distribution circuit 305.
Referring to fig. 7, fig. 7 is an equivalent circuit diagram of a tumor electric field treatment system according to an embodiment of the invention. Which is suitable for the metal substrate electrode of the embodiment of fig. 1-1. The output of the power supply V corresponds to the part of the dashed line box in fig. 3, namely the output of the signal distribution circuit 305, one end of the output is connected with the first resistor R11 and the first capacitor C11 in series, and the other end of the output is connected with the second resistor R12 and the second capacitor C12 in series; the two ends of the third resistor R0 and the third capacitor C0 are respectively connected with the first capacitor C11 and the second capacitor C12 after being connected in parallel; wherein, the first capacitor C11 or the second capacitor C12 is equivalent to the capacitor formed by the copper-clad circuit layer 10, the first insulating layer 20 and the metal substrate 30 in fig. 1; the first resistor R11 corresponds to the impedance of the first electrode, the first capacitor C11 corresponds to the equivalent capacitance of the first electrode, the second resistor R12 corresponds to the impedance of the second electrode, the second capacitor C12 corresponds to the equivalent capacitance of the second electrode, the third resistor R0 and the third capacitor C0 connected in parallel are equivalent to the human body model, an RC charge-discharge loop is integrally formed, the high-frequency signal generated by the output of the power supply V (i.e., the output of the signal distribution circuit 305) applies an electric field to the human body in a capacitive mode (repeated charge-discharge), and the electric field achieves the effect of inhibiting the proliferation of tumor cells by interfering with the mitosis process of the tumor cells.
Referring to fig. 8, fig. 8 is an equivalent circuit diagram of a tumor electric field treatment system according to an embodiment of the invention. Which is suitable for the metal substrate electrode of the embodiment of fig. 1-2. The output of the power supply V corresponds to the part of the dashed line box in fig. 3, namely the output of the signal distribution circuit 305, one end of the output is connected with the first resistor R11, the first capacitor C11 and the fourth capacitor C21 in series, and the other end of the output is connected with the second resistor R12, the second capacitor C12 and the fifth capacitor C22 in series; wherein, the first capacitor C11 or the second capacitor C12 is equivalent to the capacitor formed by the copper-clad circuit layer 10, the first insulating layer 20 and the metal substrate 30 in fig. 1-1 or fig. 1-2; the fourth capacitance C21 or the fifth capacitance C22 is equivalent to the capacitance constituted by the metal substrate 30, the second insulating layer 2, and the conductive layer 3 in fig. 1-2; the two ends of the third resistor R0 and the third capacitor C0 are respectively connected with the fourth capacitor C21 and the fifth capacitor C22 after being connected in parallel; the first resistor R11 corresponds to the impedance of the first electrode, the first capacitor C11 and the fourth capacitor C21 connected in series correspond to the equivalent capacitance of the first electrode, the second resistor R12 corresponds to the impedance of the second electrode, the second capacitor C12 and the fifth capacitor C22 connected in series correspond to the equivalent capacitance of the second electrode, the third resistor R0 and the third capacitor C0 connected in parallel are equivalent to the human body model, an RC charge-discharge loop is integrally formed, the high-frequency signal generated by the output of the power supply V (i.e., the output of the signal distribution circuit 305) applies an electric field to the human body in a capacitive mode (repeated charge-discharge), and the electric field achieves the effect of inhibiting proliferation of tumor cells by interfering with the mitosis process of the tumor cells.
The foregoing examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the protection scope of the present invention is subject to the claims.
Claims (15)
1. The utility model provides a metal substrate electrode, its characterized in that includes copper-clad circuit layer, locates the first insulating layer of copper-clad circuit layer lower extreme, locates the metal substrate of first insulating layer lower extreme, copper-clad circuit layer has first copper-clad circuit layer, second copper-clad circuit layer, third copper-clad circuit layer, first copper-clad circuit layer is used for connecting the electrode, second copper-clad circuit layer the third copper-clad circuit layer is used for connecting temperature sensor, copper-clad circuit layer top is equipped with and hinders the welding mask layer, still includes second insulating layer and conducting layer, the second insulating layer is located the below of metal substrate, the conducting layer is located the below of second insulating layer.
2. The metal substrate electrode of claim 1, wherein the second insulating layer encapsulates a side of the metal substrate.
3. The metal substrate electrode according to claim 1 or 2, wherein the metal substrate electrode is in contact with the skin through a conductive gel.
4. A metal substrate electrode according to claim 3, wherein the thickness of the conductive gel is 0.1-5mm.
5. The metal substrate electrode according to claim 1, wherein a terminal is provided at an end of the copper-clad circuit layer, and an electrode wire and the temperature sensor are connected to the copper-clad circuit layer through the terminal.
6. The metal substrate electrode according to claim 5, wherein the periphery of the connection terminal and the solder resist layer is provided with an insulating potting layer.
7. The metal substrate electrode according to claim 5, wherein the connection terminal is a pad or a socket.
8. The metal substrate electrode according to claim 1, wherein the metal substrate electrode surface is provided with an air permeable adhesive tape.
9. The metal substrate electrode according to claim 1, wherein the area of the lower surface of the metal substrate electrode is not more than 50cm 2 。
10. The metal substrate electrode according to claim 1, wherein the first insulating layer comprises epoxy glue and ceramic powder, and the mass ratio of the epoxy glue to the ceramic powder is 1:1-10:1.
11. The metal substrate electrode according to claim 1, wherein the metal substrate is one of an aluminum substrate, a copper substrate, and an iron substrate.
12. A tumor electric field treatment electrode, characterized in that a first electrode and a second electrode are respectively formed by at least two metal substrate electrodes according to any one of claims 1-11, the first electrode and the second electrode form a pair of electrodes, the first electrode is connected with a first electrode wire, and the second electrode is connected with a second electrode wire.
13. A tumor electric field treatment system, comprising a human-computer interaction interface, a control unit, a power supply unit, a voltage amplitude adjusting circuit, an inversion frequency modulation circuit and a signal distribution circuit, and further comprising the tumor electric field treatment electrode according to claim 12.
14. The tumor electric field therapy system of claim 13, wherein the tumor electric field therapy electrodes are a plurality of, the signal distribution circuit time-sharing distributes the plurality of tumor electric field therapy electrodes;
the temperature sensor on the tumor electric field treatment electrode is connected with the control unit;
the control unit is used for controlling the power supply unit, the voltage amplitude regulating circuit, the inversion frequency modulation circuit, the signal distribution circuit and the tumor electric field treatment electrode;
the power supply unit is used for supplying power to the tumor electric field treatment system;
the voltage amplitude regulating circuit, the inversion frequency modulation circuit and the signal distribution circuit are sequentially connected in series;
the tumor electric field treatment system sets control parameters through a human-computer interaction interface, and the control unit controls and modulates the output voltage of the power supply unit, the output voltage of the voltage amplitude regulating circuit, the output frequency of the inversion frequency modulation circuit and the scanning period of the signal distribution circuit to enable the control parameters to be reached, so that the temperature of the tumor electric field treatment electrode is monitored, early-warned and protected.
15. The tumor electric field therapy system according to claim 13, wherein the first electrode and the second electrode each comprise a plurality of metal substrate electrodes of the same number, a plurality of the metal substrate electrode arrays are arranged, and two adjacent metal substrate electrodes are connected to each other.
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| CN116943018A (en) * | 2023-08-04 | 2023-10-27 | 深圳奥派森生物电磁科技有限公司 | Electrode and system for tumor electric field therapy |
| CN117180617B (en) * | 2023-10-09 | 2025-01-21 | 深圳奥派森生物电磁科技有限公司 | Electrodes and systems for electric field therapy |
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