CN116492513A - A kind of temperature-sensitive wax material for automatic vas deferens of sows and its preparation method - Google Patents

Abstract

The invention belongs to the field of bionic biology technology, and specifically discloses a temperature-sensitive wax material for automatic vas deferens of sows and a preparation method thereof. The temperature-sensitive wax material for the automatic vas deferens of sows is made of the following components in weight percent: 61-69% of beeswax, 8-12% of binder, 12-18% of lubricant, and the balance of filler. The binder is gelatin; the lubricant is a mixture of glyceryl oleate and glyceryl palmitate with a mass ratio of 3-5:1. In the present invention, the beeswax, the binder, the lubricant and the filler are melted and blended in a suitable ratio, so the stability is high and the plasticity is strong; the preparation process is simple, and environmental protection is safe. The present invention can be directly applied to the living body, and the medicine and the temperature-sensitive wax material can be made into a solid preparation with a certain shape for administration in the cavity of the living body; fertilization problem. The invention greatly saves economic and time costs, and is suitable for vigorous industrial promotion.

Description

A kind of temperature-sensitive wax material for automatic vas deferens of sows and its preparation method

technical field

The invention relates to the field of bionic biology technology, and more particularly relates to a temperature-sensitive wax material for automatic vas deferens of sows and a preparation method thereof.

Background technique

In modern intensive breeding, under the background of African swine fever, artificial insemination has the advantages of improving the utilization rate of high-quality boars, reducing the amount of boars raised, reducing regional and time restrictions, and reducing the spread of diseases. Pig farm use.

The Chinese utility model patent with the authorized announcement number CN 217744696 U disclosed an automatic vas deferens device for pigs on November 08, 2022, specifically related to an automatic vas deferens, including a vas deferens body and an injection tube connected to the vas deferens body, One end of the injection pipe is fixedly connected to the safety cap, and there is a frangible part between the safety cap and the injection pipe. The interior of the injection pipe is provided with a liquid injection cavity that runs through both ends, and the cavity near the end of the safety cap is provided with a There is a first blocking layer, and a second blocking layer is provided in the cavity near the end of the vas deferens body of the injection cavity. The first blocking layer is composed of temperature-sensitive materials, and the second blocking layer is composed of water-soluble materials. When the sow needs to be impregnated, the semen is first filled into the body of the vas deferens. Since the second blocking layer is a water-soluble material, it will automatically ablate when it meets water; The injection tubes are broken at the easy-to-break places, because the injection tube is also equipped with a first blocking layer to prevent the semen from flowing out; when the injection tube is put into the sow's birth canal, because the first blocking layer is a temperature-sensitive material, the inside of the birth canal The high temperature melts the first blocking layer, and the semen is pressed into the birth canal from the body of the vas deferens.

The temperature-sensitive material of the first blocking layer in the above scheme uses mixed fatty acid glycerides, which are composed of mono-, di-, and tri-glycerides of mixed fatty acids (C10 to C18), mainly triglycerides, and the melting point of traditional fatty acid glycerides is lower than that of parent The temperature of the pig's organism, which can cause premature ejaculation of the automatic vas deferens, is expensive. Some low-temperature waxes have poor biocompatibility and will produce certain responses or rejection reactions to the host or users. The safety of biological materials must be ensured, at least to make the reactions that occur acceptable to users without harmful effects.

Contents of the invention

The purpose of the present invention is to provide a temperature-sensitive wax material for automatic vas deferens of sows and its preparation method, so as to solve the problem that the low-temperature wax effect in the prior art cannot meet the demand. The invention introduces a new biocompatible system and a stable system, which can be prepared by one-step mixing and hot melting in production. The temperature-sensitive wax material for the automatic vas deferens of sows produced has uniform components and high stability, and can significantly reduce low-temperature wax. The softening temperature is highly compatible with the user's body temperature; the temperature-sensitive wax material for the automatic vas deferens of sows provided by the invention is an oil-soluble material, not a water-soluble material, so at room temperature, bionic biological instruments such as automatic vas deferens will not Dissolved by the semen, it plays a good barrier role. When the automatic vas deferens is put into the sow, the temperature-sensitive wax material used for the automatic vas deferens when the sow becomes pregnant begins to soften when the temperature reaches the body temperature of the sow, and the semen in the automatic vas deferens passes through under a certain pressure The pipeline sprays the wax material into the body of the sow, and within the content range of the preparation specifications, the safety of the user can be effectively guaranteed without harmful effects.

To achieve the above object, the present invention adopts the following technical solutions:

One of the objects of the present invention is to provide a temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in weight percentage: beeswax 61-69% , Binder 8-12%, lubricant 12-18%, filler to 100%. The temperature-sensitive wax material for the automatic vas deferens of sows is mixed with beeswax, binder, lubricant and filler, heated until all components reach a molten state, mixed evenly, and then poured into a mold and cooled to room temperature to obtain . It should be pointed out that the heating temperature is the temperature at which the mixture is melted without oxidative decomposition.

This technical solution is based on beeswax, which is a natural product with strong plasticity and is safe and harmless; by adding a binder, the beeswax, lubricant, and filler can be effectively bonded and dispersed evenly; by adding a lubricant, the wax can be effectively increased. The overall fluidity of the material can be effectively reduced, and the softening temperature of the wax can be effectively reduced; the gap between the beeswax, binder and lubricant can be effectively filled by adding fillers, and the influence of thermal expansion can be effectively reduced. Further, the beeswax described in the above technical solution is bleached or non-bleached beeswax with a melting point of 46-60°C.

Further, the binder described in the above technical solution is gelatin. In this technical solution, gelatin is thermally reversible as a binder. The product added with gelatin will be in a solution state when heated, and will be in a frozen state after cooling. This transformation is rapid and can be repeated many times. At the same time, the basic characteristics of the product do not occur. Any changes, with strong cohesive force, can maintain the integrity of the product.

Further, the lubricant described in the above technical solution is a mixture of glyceryl oleate and glyceryl palmitate, preferably a mixture of glyceryl oleate and glyceryl palmitate with a mass ratio of 3-5:1. Glyceryl oleate and glyceryl palmitate both have a lubricating effect, can effectively melt into beeswax, and reduce the overall melting range and softening temperature.

Further, the filler described in the above technical solution is cocoa butter. The melting point of cocoa butter is close to the average human body temperature, so it can maintain a solid state at room temperature. It is a stable and easy-to-preserve fat. It has good compatibility with beeswax. In this technical solution, cocoa butter will not affect the The melting point of the entire wax is significantly affected.

The second object of the present invention is to provide a method for preparing the temperature-sensitive wax material for automatic vas deferens of sows described in one of the objects of the present invention, comprising the following steps:

S1. Pulverize the beeswax, binder and filler into powders, sieve them, weigh them according to the proportion, and set aside;

S2. Add beeswax, binder and filler to the heat-collecting magnetic stirrer to stir and mix the powder evenly;

S3. adding the lubricant to the heat-collecting magnetic stirrer, stirring while heating, until the beeswax, binder, filler and lubricant are fully melted and mixed uniformly;

S4. Pour the homogeneously melted material into the mold and wait for it to cool down, and take it out to obtain the temperature-sensitive wax material for the automatic vas deferens of sows.

In this technical solution, first mix the beeswax, binder and filler evenly, then add the lubricant, stir while heating, so that all components reach a molten state, and continue to stir to make them fully mixed evenly, and then pour the molten material Put it into the mold and cool to room temperature, and the obtained temperature-sensitive wax material for the automatic vas deferens of sows is highly compatible with the user's body temperature, and will not produce harmful effects.

Further, in the above technical solution S1, the powder is passed through a 100-150 mesh sieve.

Further, in the above technical solution S2, the stirring speed is 30-50r/min, and the mixing time is preferably 8-12min.

Further, in the above technical solution S3, the heating and stirring conditions are as follows: the stirring speed is 60-100 r/min, and the heating temperature is selected to melt the mixture without oxidative decomposition, preferably the heating temperature is 90-120°C , the preferred mixing time is 15-30min.

Further, in the above technical solution S4, the injection molding conditions are as follows: the surface of the mold is smooth, clean and hygienic.

The third object of the present invention is to provide the application of the temperature-sensitive wax material for the automatic vas deferens of sows described in one of the objects of the present invention in making a solid preparation with a certain shape for administration in the cavity of a living body. The medicine and the temperature-sensitive wax material for the automatic vas deferens of sows are made into a solid preparation with a certain shape for intracavity administration of a living body.

The fourth object of the present invention is to provide the temperature-sensitive wax material for the automatic vas deferens of sows described in one of the objects of the present invention in cooperation with bionic biological instruments such as automatic vas deferens, especially in the Chinese utility model whose authorization announcement number is CN 217744696U. The vas deferens, made into some parts to improve its application in the fertilization of organisms.

Compared with prior art, the beneficial effect of the present invention:

1. The softening temperature of beeswax is higher than the body temperature of pigs, so it is not suitable for direct use of automatic vas deferens. The present invention effectively reduces the softening temperature of the beeswax by adding oleic acid glyceride and palmitic acid glyceride to the beeswax, and effectively mixes and melts the beeswax to perfectly match the automatic insemination device. The temperature-sensitive wax material for the automatic vas deferens of sows provided by the present invention is an oil-soluble material, not a water-soluble material, so at room temperature, bionic biological devices such as automatic vas deferens used as parts will not be dissolved by semen, and play a good barrier effect , when the automatic vas deferens is put into the sow's body, the temperature-sensitive wax material used for the automatic vas deferens for the sow's conception begins to soften when the temperature reaches the sow's body temperature, and the semen in the automatic vas deferens sprays the wax material into the sow's body through the pipeline under a certain pressure ;

2. The biocompatibility of the present invention is good, and all components will not produce a certain response or rejection reaction to the host or the user, and the biocompatible wax material is guaranteed to be safe and will not produce harmful effects;

3. In the present invention, beeswax, binder, lubricant and filler are melt-blended in a suitable ratio to reach a stable state, so that it can be stored stably for a long time. The temperature-sensitive wax material for the automatic vas deferens of sows in the invention simplifies the production process, adopts biocompatible materials, effectively simplifies the production process, and reduces economic and time costs.

Description of drawings

Fig. 1 is the apparent state of the temperature-sensitive wax material for the automatic vas deferens of sows prepared in Example 1 of the present invention at different temperatures. The temperature-sensitive wax material in the left picture is in a flowing liquid state at 38°C, and the temperature-sensitive wax material in the right picture is in a solidified state at 25°C.

Figure 2 is a graph showing the rheological results of the temperature-sensitive wax material for the automatic vas deferens of sows prepared in Example 1 of the present invention, specifically the curves of storage modulus (G') and loss modulus (G") with temperature The figure shows the change of viscoelasticity of the temperature-sensitive wax material in the range of 25-55°C. It can be seen that the temperature-sensitive wax material is in a viscous fluid state at 35-45°C, which is in line with the body temperature characteristics of organisms.

Fig. 3 is the DSC curve of the temperature-sensitive wax material for the automatic vas deferens of sows prepared in Example 1 of the present invention. It can be found that there is an obvious melting peak, and it can be seen that the melting range of the temperature-sensitive wax material for the automatic vas deferens of sows prepared in Example 1 is 36-42 ° C, and the melting point is 40 ° C, which is in line with the body temperature characteristics of organisms.

Fig. 4 is a schematic diagram of the situation after the temperature-sensitive wax material for automatic vas deferens of sows prepared in Example 1 of the present invention is dissolved in ethyl acetate for 2 minutes. The temperature-sensitive wax material for the automatic vas deferens of pigs can be dissolved in ethyl acetate at 35°C and 40°C.

Figure 5 is a schematic diagram of the temperature-sensitive wax material for the automatic vas deferens of sows prepared in Example 1 of the present invention after being dissolved in water for 2 minutes. The temperature-sensitive wax material for vas deferens is difficult to dissolve in water at 35°C and 40°C.

Detailed ways

The present invention will be further elaborated below in conjunction with specific embodiments, and unless otherwise specified, all are conventional methods. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of protection claimed by the present invention. In addition, it should be understood that after reading the contents of the present invention, those skilled in the art can make various changes to the present invention, and these equivalent forms all belong to the protection scope of the present invention.

The raw materials used in the following examples and comparative examples, if not specifically limited, are all disclosed in the prior art, for example, can be directly purchased or obtained according to the preparation method disclosed in the prior art.

Raw materials used in the following examples and comparative examples are beeswax (CAS: 8012-89-3, bleached, melting point: 46-60°C), gelatin (CAS: 9000-70-8), xanthan gum, glyceryl oleate, palmitic acid Glycerides, cocoa butter (CAS: 8002-31-1), etc. were purchased from Adamas.

Example 1

A temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in weight percentage: 61% beeswax, 8% binder, 12% lubricant, and 19% filler, wherein, the binder It is gelatin, the lubricant is a mixture of glyceryl oleate and glyceryl palmitate, the mass ratio of glyceryl oleate to glyceryl palmitate is 3:1; the filler is cocoa butter.

Include the following specific steps:

S1. Taking the preparation of 50 g of the temperature-sensitive wax material for the automatic vas deferens of sows as an example, pulverize the beeswax, binder, and filler respectively into powders, pass through a 100-mesh sieve, weigh according to the proportion, and set aside;

S2. Add beeswax, binder, and filler to the heat-collecting magnetic stirrer, stir at a stirring speed of 30r/min for 8min, and stir and mix the powder evenly;

S3. Add the lubricant to the heat-collecting magnetic stirrer, stir while heating, the stirring speed is 60r/min, heat to 90°C and continue stirring for 15min, so that the beeswax, binder, filler, and lubricant are fully melted and mixed Uniform;

S4. Pour the material obtained by melting and mixing uniformly in step S3 into a mold with a smooth and clean surface, wait for it to cool, and take it out to obtain the temperature-sensitive wax material for automatic vas deferens for sow insemination.

Example 2

A temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in weight percent: 63% beeswax, 10% binder, 14% lubricant, and 13% filler, wherein the binder It is gelatin, the lubricant is a mixture of glyceryl oleate and glyceryl palmitate, the mass ratio of glyceryl oleate to glyceryl palmitate is 4:1; the filler is cocoa butter.

Include the following specific steps:

S1. Taking the preparation of 50 g of the temperature-sensitive wax material for the automatic vas deferens of sows as an example, pulverize the beeswax, binder, and filler respectively into powders, pass through a 100-mesh sieve, weigh according to the proportion, and set aside;

S2. Add beeswax, binder, and filler to the heat-collecting magnetic stirrer, and stir at a stirring speed of 40r/min for 10min to make the powder evenly mixed;

S3. Add the lubricant to the heat-collecting magnetic stirrer, stir while heating, the stirring speed is 70r/min, heat to 100°C and continue stirring for 15min, so that the beeswax, binder, filler, and lubricant are fully melted and mixed Uniform;

S4. Pour the material obtained by melting and mixing uniformly in step S3 into a mold with a smooth and clean surface, wait for it to cool, and take it out to obtain the temperature-sensitive wax material for automatic vas deferens for sow insemination.

Example 3

A temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in percentage by weight: 66% beeswax, 10% binder, 16% lubricant, and 8% filler, wherein the binder It is gelatin, the lubricant is a mixture of glyceryl oleate and glyceryl palmitate, the mass ratio of glyceryl oleate to glyceryl palmitate is 4:1; the filler is cocoa butter.

Include the following specific steps:

S1. Taking the preparation of 50 g of the temperature-sensitive wax material for the automatic vas deferens of sows as an example, pulverize the beeswax, binder, and filler respectively into powders, pass through a 150-mesh sieve, weigh according to the proportion, and set aside;

S2. Add beeswax, binder, and filler to the heat-collecting magnetic stirrer, and stir for 12 minutes at a stirring speed of 40r/min, so that the powder is stirred and mixed evenly;

S3. Add the lubricant to the heat-collecting magnetic stirrer, stir while heating, the stirring speed is 90r/min, heat to 110°C and continue stirring for 25min, so that the beeswax, binder, filler, and lubricant are fully melted and mixed Uniform;

S4. Pour the material obtained by melting and mixing uniformly in step S3 into a mold with a smooth and clean surface, wait for it to cool, and take it out to obtain the temperature-sensitive wax material for automatic vas deferens for sow insemination.

Example 4

A temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in weight percentage: 69% beeswax, 10% binder, 18% lubricant, and 3% filler, wherein the binder It is gelatin, the lubricant is a mixture of glyceryl oleate and glyceryl palmitate, the mass ratio of glyceryl oleate to glyceryl palmitate is 5:1, and the filler is cocoa butter.

Include the following specific steps:

S1. Taking the preparation of 50 g of the temperature-sensitive wax material for the automatic vas deferens of sows as an example, pulverize the beeswax, binder, and filler respectively into powders, pass through a 150-mesh sieve, weigh according to the proportion, and set aside;

S2. Add beeswax, binder, and filler to a heat-collecting magnetic stirrer, and stir for 12 minutes at a stirring speed of 50 r/min, so that the powder is stirred and mixed evenly;

S3. Add the lubricant to the heat-collecting magnetic stirrer, stir while heating, the stirring speed is 100r/min, heat to 120°C and continue stirring for 30min, so that the beeswax, binder, filler, and lubricant are fully melted and mixed Uniform;

S4. Pour the material obtained by melting and mixing uniformly in step S3 into a mold with a smooth and clean surface, wait for it to cool, and take it out to obtain the temperature-sensitive wax material for automatic vas deferens for sow insemination.

Comparative example 1

A temperature-sensitive wax material for automatic vas deferens of sows, its components, component percentages and preparation method are basically the same as in Example 4, the only difference is that the binder used is xanthan gum.

Comparative example 2

A temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in percentage by weight: 72% beeswax, 10% binder, 14% lubricant, 4% filler, its components, preparation Method is identical with embodiment 4.

Comparative example 3

A temperature-sensitive wax material for automatic vas deferens of sows, its components, component percentages and preparation method are basically the same as in Example 4, the only difference is that the lubricant used is oleic acid glyceride.

Comparative example 4

A temperature-sensitive wax material for the automatic vas deferens of sows, which is made of the following components in weight percentage: 55% beeswax, 12% binder, 18% lubricant, 15% filler, its components, preparation Method is identical with embodiment 4.

Carry out the test and the record of softening temperature to the temperature-sensitive wax material of automatic vas deferens for sows prepared in embodiment 1-4 and comparative example 1-4, and the automatic vas deferens for sows prepared with temperature-sensitive wax material (hereinafter referred to as "Wax material", no longer repeat) is placed among the automatic vas deferens in the Chinese utility model patent embodiment 1 of authorized announcement number CN 217744696 U as the first blocking layer. Stop timing when the wax begins to soften and ejaculate ejaculate in the sow, measure the softening temperature (melting range) and record the time it takes to melt. In particular, inject the wax prepared in each case into the automatic vas deferens, the content of wax in each vas deferens is 5mg, take 1000 samples from each case for the simulation test of in vivo fertilization in sows, and record the softening temperature range of each sample and softening time range.

Table 1 softening temperature range results (pieces)

group Below 34°C 34-36℃ 36-38℃ 38-40℃ 40-42℃ Above 42°C Example 1 0 58 562 369 11 0 Example 2 0 44 503 394 59 0 Example 3 0 twenty two 475 457 46 0 Example 4 0 8 412 488 92 0 Comparative example 1 0 0 7 19 589 385 Comparative example 2 0 0 12 27 654 307 Comparative example 3 0 65 239 241 295 160 Comparative example 4 426 454 75 45 0 0

Note: The group setting of softening temperature is 34-36°C, 36-38°C, 38-40°C, and 40-42°C. The temperature range does not include the left end point value and includes the right end point value. Taking 38°C as an example, it is included in 36°C -38°C range. The softening temperature is below 34°C and above 42°C, which deviates too much from the birth canal temperature of sows and has no reference value.

As can be seen from the results in Table 1, the softening temperature of the temperature-sensitive wax material for the automatic vas deferens of sows obtained by adopting the formula of the present invention and the preparation method (embodiment 1-4) is concentrated at 36-40 ° C, which meets the temperature of the sow's birth canal. In this temperature range, the wax material can melt, while the binder in Comparative Example 1 uses xanthan gum, which has a higher melting point than gelatin, so the softening temperature is mostly concentrated above 40°C; in Comparative Example 2, the content of beeswax is relatively high, and the softening temperature is mostly Concentrated above 40°C; only glycerol oleate was added to the lubricant in Comparative Example 3, which would cause uneven mixing of various material components, resulting in a high softening temperature of the product, non-concentrated softening temperature distribution, and a low product qualification rate; The beeswax content in comparative example 4 is on the low side, and the softening temperature of the obtained product is on the low side, and the softening temperature is mostly concentrated below 40°C.

Table 2 softening time range results (pieces)

group 0-1min 1-2min 2-3min 3-4min 4-5min more than 5min Example 1 0 525 453 twenty two 0 0 Example 2 0 503 452 45 0 0 Example 3 0 485 459 56 0 0 Example 4 0 469 463 68 0 0 Comparative example 1 0 31 85 365 256 263 Comparative example 2 0 45 96 331 243 285 Comparative example 3 69 56 286 248 256 85 Comparative example 4 846 106 48 0 0 0

Note: The group setting of softening time is 0-1min, 1-2min, 2-3min, 3-4min, and 4-5min. within 2 minutes. The softening time is below 1min and above 5min ℃, which deviates from the normal artificial insemination time of sows and has no reference value.

As can be seen from the results in Table 2, the softening time of the temperature-sensitive wax material for the automatic vas deferens of sows obtained by adopting the formula and preparation method of the present invention (Example 1-4) is concentrated in 1-3min, which meets the time requirement of artificial insemination. In Comparative Example 1, xanthan gum was used as the binder, which has a higher melting point than gelatin, and the final wax softening temperature is relatively high, so the softening time is mostly concentrated above 3 minutes; in Comparative Example 2, the content of beeswax is relatively high, and the final wax softening temperature is relatively high , the softening time is mostly concentrated above 3 minutes; only glycerol oleate is added to the lubricant in Comparative Example 3, which will make the mixing of various material components uneven, the softening temperature of the obtained product is high, the softening time distribution is not concentrated, and the product is qualified The beeswax content in comparative example 4 is on the low side, and the softening temperature of the product obtained is on the low side, and the softening time is mostly concentrated within 1min.

To sum up, the temperature-sensitive wax material for the automatic vas deferens of sows in the present invention has good biocompatibility, conforms to the characteristics of biological signs, high stability, and is easy to use through a reasonable proportion and a simple and scientific mixing method.

Finally, it should be emphasized that the above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. It should be pointed out that for those skilled in the art, they can also Several improvements and modifications are made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims (10)

1. A temperature-sensitive wax material for the automatic vas deferens of sows, characterized in that it is made of the following components in percentage by weight: 61-69% beeswax, 8-12% binder, and 12-18% lubricant %, fillers make up to 100%; The binder is gelatin; the lubricant is a mixture of glyceryl oleate and glyceryl palmitate. 2. A kind of temperature-sensitive wax material for automatic vas deferens of sows according to claim 1, characterized in that, the lubricant is that the mass ratio of glyceryl oleate to glyceryl palmitate is 3-5:1 mixture. 3 . The temperature-sensitive wax material for automatic vas deferens of sows according to claim 1 , wherein the melting point of the beeswax is 46-60° C. 4. The temperature-sensitive wax material for automatic vas deferens of sows according to any one of claims 1-3, characterized in that the filler is cocoa butter. 5. according to the preparation method of a kind of sow fertilization automatic vas deferens described in any one of claim 1-4, is characterized in that, comprises the following specific steps: S1. Pulverize the beeswax, binder and filler into powders, sieve them, weigh them according to the proportion, and set aside; S2. Add beeswax, binder and filler to the heat-collecting magnetic stirrer to stir and mix the powder evenly; S3. adding the lubricant to the heat-collecting magnetic stirrer, stirring while heating, until the beeswax, binder, filler and lubricant are fully melted and mixed uniformly; S4. Pour the homogeneously melted material into the mold and wait for it to cool down, and take it out to obtain the temperature-sensitive wax material for the automatic vas deferens of sows. 6. A method for preparing a temperature-sensitive wax material for automatic vas deferens of sows according to claim 5, characterized in that, in step S1, the powders of the beeswax, binder and filler are over 100-150 mesh screen. 7. The method for preparing a temperature-sensitive wax material for automatic vas deferens of sows according to claim 5, characterized in that, in step S2, the stirring speed is 30-50r/min, and the mixing time is 8-12min. 8. A method for preparing a temperature-sensitive wax material for automatic vas deferens of sows according to claim 5, characterized in that, in step S3, the stirring speed is 60-100r/min, the heating temperature is 90-120°C, The mixing time is 15-30min. 9 . The method for preparing a temperature-sensitive wax material for automatic vas deferens of sows according to claim 5 , characterized in that, in step S4 , the mold used has a smooth surface and is clean and hygienic. 10. The temperature-sensitive wax material for automatic vas deferens for sow pregnancy described in any one of claims 1-4 is made into a solid preparation with a certain shape for administration in the body cavity or in cooperation with bionic biological instruments such as automatic vas deferens, Some parts are made to improve its application in the fertilization of organisms.