CN117122734B

CN117122734B - Preparation method of bone repair raw material, bone repair raw material and application thereof

Info

Publication number: CN117122734B
Application number: CN202311096242.0A
Authority: CN
Inventors: 崔嵬; 洪东立; 陈进庆
Original assignee: Changzhou Banglai Medical Technology Co ltd
Current assignee: Changzhou Banglai Medical Technology Co ltd
Priority date: 2023-08-29
Filing date: 2023-08-29
Publication date: 2025-05-16
Anticipated expiration: 2043-08-29
Also published as: CN117122734A

Abstract

The invention discloses a preparation method of a bone repair raw material, the bone repair raw material and application thereof. A preparation method of a bone repair raw material comprises the following steps of (i) preparing a mixed solution of calcium salt and magnesium salt as a first solution, preparing a phosphate solution, adjusting the pH value to 9.5-10.5 by using alkali liquor as a second solution, (ii) heating and mixing the first solution and the second solution, reacting at 60-95 ℃ under the condition of stirring, and (iii) centrifugally separating a suspension obtained after the reaction in the step (ii) to obtain a precipitate, cleaning, and spray-drying the cleaned precipitate to obtain a powdery porous bone repair raw material. The preparation method has mild reaction conditions and reduces the production cost, and the prepared bone repair raw material is a low-density porous powder material and has high combination property with high polymer materials such as collagen.

Description

Preparation method of bone repair raw material, bone repair raw material and application thereof

Technical Field

The invention relates to a preparation method of a bone repair raw material, in particular to a preparation method of a magnesium-containing tricalcium phosphate bone repair powder raw material, which can be used for preparing a bone repair body.

Background

As the aging degree of the population further increases, the incidence of bone injuries caused by various chronic diseases, traffic accidents, industrial injuries and sports injuries increases year by year, and development of novel artificial bone materials for repairing bone defects is urgently needed. The existing bone repair materials mainly comprise hydroxyapatite, and show certain biocompatibility after being implanted into a body, but hardly degrade and metabolize in the body. Studies have shown that hydroxyapatite has no obvious change after being implanted into a bone defect site in vivo for several years, thus preventing the growth of new bone, see literature 1：Dorozhkin S.V.,Epple M.Biological and medical significance of calcium phosphates.Angew.Chem.Int.Ed.2002,41:3130-3146.

The tricalcium phosphate material has better degradation performance compared with hydroxyapatite, and can be chemically combined with bone after being implanted into a body. However, hydroxyapatite is easily crystallized in liquid phase synthesis, and tricalcium phosphate is difficult to form. As such, tricalcium phosphate raw materials are generally prepared by high-temperature calcination or solid-phase reaction at a temperature of more than 1000 ℃, consume a large amount of energy, and have dense micron-sized powder product particles, high density and irregular surface, and are difficult to meet the requirements of 3D printing and application of some novel bone repair composite materials, see literature 2：Yadav M.K.,Pandey V.and et al.A low-cost approach to develop silica doped Tricalcium Phosphate(TCP)scaffold by valorizing animal bone waste and rice husk for tissue engineering applications.Ceram.Int.2022,48:25335-25345.

Patent ZL201610290891.8 discloses a method for preparing beta-phase tricalcium phosphate crystal material under low temperature condition, which comprises mixing Ca (Mg, sr) and P source at normal temperature to prepare amorphous calcium phosphate material, then placing into a hydrothermal reaction kettle, crystallizing at high temperature and high pressure (160-250 ℃ and 1.5 MPa) to form tricalcium phosphate crystal material, and the grain size is 30-100nm. Compared with the traditional process for preparing the tricalcium phosphate material by high-temperature calcination, the method converts amorphous calcium phosphate into tricalcium phosphate crystals by a hydrothermal condition of 160-250 ℃ and 1.5MPa, so that the production cost can be effectively reduced, and the nanoscale tricalcium phosphate powder is obtained. However, the hydrothermal condition of high temperature and high pressure of the method makes the preparation method difficult to be applied on a large scale, and the obtained nano tricalcium phosphate powder often causes powder to fall off to induce inflammatory reaction due to weak binding force when being applied to a novel bone repair composite material.

Therefore, there is a need to develop a tricalcium phosphate bone repair material suitable for preparing bone repair body, which has milder preparation conditions and stronger binding force of composite materials.

Disclosure of Invention

The invention aims to provide a preparation method of a bone repair raw material, which has mild reaction conditions and reduced production cost, wherein the prepared bone repair raw material is a low-density porous powder material and has good binding property with high polymer materials such as collagen. The bone repair raw material is suitable for preparing bone repair bodies, wherein the bone repair raw material has better combination property and dispersibility in high polymer materials such as collagen, and solves the problems of falling and inflammation of nano tricalcium phosphate powder in the application process.

The first aspect of the present invention provides a method for preparing a bone repair material, comprising the steps of:

(i) Preparing a mixed solution of calcium salt and magnesium salt as a first solution, preparing a phosphate solution, and adjusting the pH to 9.5-10.5 by alkali liquor as a second solution;

(ii) Heating and mixing the first solution and the second solution, and reacting under the conditions of 60-95 ℃ and stirring;

(iii) And (3) centrifugally separating the suspension obtained after the reaction in the step (ii) to obtain a precipitate, cleaning, and spray-drying the cleaned precipitate to obtain the powdery porous bone repair raw material.

In a preferred embodiment, the molar concentration ratio of calcium ions to magnesium ions in the first solution is 6-10.

In a more preferred embodiment, the molar concentration of calcium ions in the first solution is 0.01-0.9 mol/L, more preferably 0.1-0.8 mol/L, still more preferably 0.2-0.6 mol/L. For example, the molar concentration of calcium ions is 0.01mol/L, 0.05mol/L, 0.08mol/L, 0.1mol/L, 0.2mol/L, 0.3mol/L, 0.4mol/L, 0.5mol/L, 0.6mol/L, 0.7mol/L or 0.8mol/L.

In a more preferred embodiment, the molar concentration of magnesium ions in the first solution is 0.001 to 0.15mol/L, more preferably 0.01 to 0.15mol/L, still more preferably 0.01 to 0.1mol/L, and especially 0.05 to 0.08mol/L. For example, the molar concentration of magnesium ions is 0.001mol/L、0.005mol/L、0.008mol/L、0.01mol/L、0.02mol/L、0.03mol/L、0.04mol/L、0.05mol/L、0.06mol/L、0.07mol/L、0.08mol/L、0.09mol/L、0.1mol/L、0.12mol/L or 0.15mol/L.

Optionally, the concentration of the calcium salt is 1 to 100g/L, more preferably 30 to 100g/L, still more preferably 50 to 100g/L, still more preferably 60 to 90g/L, in particular 80 to 90g/L, for example 80g/L, 82g/L, 84g/L, 86g/L, 88g/L or 90g/L by weight. Optionally, the concentration of magnesium salt is 0.4 to 40g/L, more preferably 0.4 to 30g/L, still more preferably 5 to 30g/L, still more preferably 15 to 30g/L, in particular 20 to 30g/L, for example 20g/L, 22g/L, 24g/L, 25g/L, 27g/L or 29g/L.

In a preferred embodiment, after the first solution and the second solution are mixed, the molar ratio of calcium ions to phosphate ions is 1.1-1.5.

In a more preferred embodiment, the molar concentration of phosphate in the second solution is 0.008 to 0.8mol/L, more preferably 0.01 to 0.8mol/L, still more preferably 0.05 to 0.8mol/L, and especially 0.1 to 0.5mol/L. For example, the molar concentration of phosphate is 0.008mol/L、0.009mol/L、0.01mol/L、0.02mol/L、0.03mol/L、0.04mol/L、0.05mol/L、0.06mol/L、0.07mol/L、0.08mol/L、0.09mol/L、0.1mol/L、0.2mol/L、0.3mol/L、0.4mol/L、0.5mol/L、0.6mol/L、0.7mol/L or 0.8mol/L.

Optionally, the concentration of phosphate in the second solution is 1-100 g/L, more preferably 30-100 g/L, still more preferably 50-90 g/L, still more preferably 70-90 g/L, especially 80-90 g/L, for example 81g/L, 83g/L, 84g/L, 85g/L, 87g/L or 88g/L by weight.

Further, the first solution and the second solution are mixed in equal volumes.

In a preferred embodiment, the solvent of the first solution is water and the solvent of the second solution is water. Alternatively, the solvent of the first solution is selected from the group consisting of one or more of methanol, ethanol, and water, and the solvent of the second solution is selected from the group consisting of one or more of methanol, ethanol, and water.

In a preferred embodiment, the calcium salt is selected from one or more of anhydrous calcium chloride, calcium chloride dihydrate and calcium nitrate tetrahydrate, the magnesium salt is selected from magnesium chloride hexahydrate and/or magnesium nitrate hexahydrate, and the phosphate salt is selected from a combination of more of one of disodium hydrogen phosphate, diammonium hydrogen phosphate and sodium hydrogen phosphate. In a preferred embodiment, the lye is ammonia or sodium hydroxide.

In a preferred embodiment, in the step (i), ammonia is used to adjust the pH of the second solution to 9.8-10.2. More preferably, the pH of the second solution is 9.8-10.0.

In a preferred embodiment, in step (ii), the first solution and the second solution are heated to 60-95 ℃ and mixed.

In a preferred embodiment, in step (ii), the stirring speed is 100 to 500rpm.

In a preferred embodiment, in step (ii), the reaction is carried out under atmospheric pressure.

In a preferred embodiment, in step (iii), the cleaned precipitate is spray dried using a spray dryer with an inlet air temperature of 240-300 ℃, an outlet air temperature of 120-150 ℃ and a feed rate of 30-200 ml/min.

In a preferred embodiment, in step (iii), the precipitate is added into water for centrifugal washing for a plurality of times, the washed precipitate is added into water with the mass of 5-20 times, and the mixture is stirred uniformly to form slurry, and then spray drying is carried out.

In a specific and preferred embodiment, the preparation method is carried out as follows:

dissolving calcium salt and magnesium salt in water to obtain a first solution, wherein the concentration of the calcium salt is 1-100 g/L, and the concentration of the magnesium salt is 0.4-40 g/L;

dissolving phosphate in water, and regulating the pH to 9.5-10.5 by using ammonia water to obtain a second solution, wherein the concentration of the phosphate is 1-100 g/L;

Heating the first solution and the second solution with equal volumes to 60-95 ℃ and then mixing, and reacting at normal pressure under stirring conditions to generate suspension, wherein the stirring speed is 100-500 rpm;

and centrifugally separating the suspension obtained after the reaction to obtain a precipitate, centrifugally cleaning the precipitate with water for 4-8 times, adding the cleaned precipitate into water with the mass of 5-20 times, uniformly stirring to form slurry, and treating the slurry into micron-sized porous tricalcium phosphate powder by using a spray dryer to obtain the bone repair raw material, wherein the air inlet temperature of the spray dryer is 240-300 ℃, the air outlet temperature is 120-150 ℃, and the feeding rate is 30-200 mL/min.

The second aspect of the present invention provides a bone repair material prepared by the above method, wherein the bone repair material is in a powder form and has a porous structure, and the particle size is 1-20 μm.

In a third aspect, the present invention provides the use of the bone repair material in the preparation of a bone repair body.

Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:

According to the preparation method, the calcium/magnesium mixed solution and the phosphate solution are subjected to direct wet chemical reaction at the normal pressure of 60-95 ℃ to generate the magnesium-containing tricalcium phosphate suspension, the magnesium-containing tricalcium phosphate suspension is shaped through spray drying to obtain the low-density porous magnesium-containing tricalcium phosphate powder with the particle size of 1-20 mu m, the reaction condition is mild, the preparation process is simple, the preparation process is avoided by using a high-temperature calcination process or through a solid phase reaction, the porous structure can provide better binding force and dispersibility in the process of preparing the bone prosthesis, and the obtained powder material can effectively promote the osteogenic differentiation of bone tissue cells and promote the generation of new bones. In the process of preparing the bone prosthesis by the powder material, the special porous structure can lead tricalcium phosphate and high polymer (such as collagen) to form an interlocking structure, thereby remarkably improving the body binding property and solving the problems of falling and inflammation of nanometer tricalcium phosphate powder in the application process.

Drawings

In order to more clearly illustrate the technical solutions of the present invention, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is an XRD pattern of the powder material prepared in example 1 of the present invention.

Fig. 2 is an SEM micro morphology of the powder material prepared in example 1 of the present invention.

FIG. 3 is an interpenetrating microstructure of the powder material prepared in example 1 of the present invention after being compounded with collagen.

Fig. 4 is an XRD pattern of the powder material prepared in example 2 of the present invention.

Fig. 5 is an XRD pattern of the powder material prepared in comparative example 1.

Fig. 6 is an XRD pattern of the powder material prepared in comparative example 2.

Detailed Description

Preferred embodiments of the present invention will be described in detail below with reference to the attached drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art. The description of these embodiments is provided to assist understanding of the present invention, but is not intended to limit the present invention. In addition, technical features of the embodiments of the present invention described below may be combined with each other as long as they do not collide with each other.

Compared with hydroxyapatite, the tricalcium phosphate material has better degradation performance, so that the tricalcium phosphate material has remarkable advantages in application of bone repair materials. However, since the solubility product (10-57.8) of hydroxyapatite is far lower than that of tricalcium phosphate material (10-28.7), hydroxyapatite is easily crystallized in liquid phase synthesis, and tricalcium phosphate is difficult to form. Tricalcium phosphate raw materials are usually prepared by high-temperature calcination or solid-phase reaction at a temperature of 1000 ℃ or higher, consume a large amount of energy, and have micron-sized product particles, high density and irregular surface. At present, although some manufacturers can stably produce tricalcium phosphate powder raw materials, most of the raw materials are calcined through a solid phase reaction method, the powder is crushed through mechanical grinding, the manufacturing cost is high, the sintered crystal grains are large, the shape is in an irregular geometric shape, and the fluidity is poor in the process of preparing the liquid phase composite material. The application provides a novel method for preparing magnesium-containing tricalcium phosphate powder based on wet chemical reaction, which is characterized in that magnesium-containing tricalcium phosphate suspension is generated by direct wet chemical reaction in a 60-95 ℃ normal pressure environment, and the low-density porous magnesium-containing tricalcium phosphate powder with the thickness of 1-20 mu m is obtained by a special forming mode of spray drying, and the porous structure can provide better binding force and dispersibility in the process of preparing a bone repair body.

Firstly, the method solves the problem that tricalcium phosphate cannot be prepared at low temperature, develops a tricalcium phosphate low-temperature chemical synthesis process by regulating and controlling an ion combination path in a liquid phase reaction, has the reaction temperature as low as 60-95 ℃, greatly reduces the production cost by more than 90%, and avoids the severe reaction conditions (160-250 ℃ and 1.5 MPa) of high-temperature calcination (more than 1000 ℃) and hydrothermal synthesis. And secondly, the powder material prepared by the application is doped with active magnesium element, so that osteogenic differentiation of bone tissue cells can be effectively promoted, and new bone formation can be promoted. Aiming at the problems of weak binding force, poor dispersibility and the like of the tricalcium phosphate material in the application process, the active tricalcium phosphate material synthesized by the low-temperature wet chemical method forms micron-sized low-density porous powder through a spray drying process, and the special porous structure can enable the tricalcium phosphate powder to form an interlocking structure with high polymers such as collagen and the like in the preparation process of the bone repair body, so that the tricalcium phosphate material has good dispersibility and bondability, solves the problems of falling and inflammation of the nanometer tricalcium phosphate powder in the application process, and has important practical application value.

The preparation method of the bone repair raw material specifically comprises the following steps:

(1) And dissolving calcium salt and magnesium salt in water to obtain a first solution, wherein the concentration of the calcium salt is 1-100 g/L, and the concentration of the magnesium salt is 0.4-40 g/L. Further, the molar ratio of calcium ion to magnesium ion is 6 to 10, more preferably 7 to 10, still more preferably 7 to 9, for example, 6.0, 7.0, 8.0, 9.0, 10.0.

(2) And dissolving phosphate in water, and adjusting the pH to 9.5-10.5 by using ammonia water to obtain a second solution, wherein the concentration of the phosphate is 1-100 g/L.

(3) Heating the first solution and the second solution with equal volumes to 60-95 ℃ and then mixing, and carrying out wet chemical reaction under normal pressure under stirring conditions, wherein the stirring speed is 100-500 rpm. The molar ratio of calcium ions to phosphate ions is 1.1 to 1.5, preferably 1.1 to 1.4, more preferably 1.2 to 1.4, for example 1.1, 1.2, 1.3, 1.4, 1.5.

(4) Centrifuging the suspension after wet chemical reaction to obtain a precipitate, centrifugally cleaning the precipitate with water for 4-8 times, adding the cleaned precipitate into water with the mass of 5-20 times, uniformly stirring to form slurry, and treating the slurry into micron-sized porous tricalcium phosphate powder by using a spray dryer to obtain the bone repair raw material, wherein the air inlet temperature of the spray dryer is 240-300 ℃, the air outlet temperature is 120-150 ℃, and the feeding rate is 30-200 mL/min.

The micron-sized porous tricalcium phosphate powder has the particle size of 1-20 mu m, is in a porous structure in a microcosmic manner, contains 1-2wt% of magnesium element, preferably 1.3-1.9wt%, shows excellent bioactivity, and effectively promotes new bone formation.

The micron-sized porous tricalcium phosphate powder and the high polymer material (such as collagen) are uniformly mixed to prepare slurry, and the slurry is dried and molded to prepare the molded bone prosthesis.

Example 1

Weighing and dissolving 900g of anhydrous calcium chloride and 270g of magnesium chloride hexahydrate, dissolving in 10L of water to obtain a solution A, weighing 830g of diammonium phosphate, dissolving in 10L of water, and regulating the pH value of the solution to 10.0 by using ammonia water to obtain a solution B.

Heating and mixing, namely heating the solution A and the solution B to 70 ℃ and mixing, and continuously stirring at a rotating speed of 100rpm to form a suspension.

Wet chemical reaction the mixed suspension was heated at 70 ℃ and stirred at 100rpm for 12 hours.

And (3) centrifugal cleaning, namely centrifuging the suspension subjected to wet chemical reaction at 2000rpm for 3 minutes to obtain a precipitate, and adding water for centrifugal cleaning for 5 times.

Spray drying, namely adding the cleaned precipitate into 10L of water, and stirring uniformly to form slurry. Setting the air inlet temperature of a spray dryer to be 250 ℃, setting the air outlet temperature to be 120 ℃, and spray-drying the slurry at the speed of 50mL/min to finally obtain the micron-sized low-density porous tricalcium phosphate powder, wherein the particle size distribution is in the range of 1-20 mu m.

The X-ray diffraction result of the micron-sized low-density porous tricalcium phosphate powder is shown in figure 1, wherein the mass percentage of magnesium element is 1.9%. The micro-morphology of the micron-sized low-density porous tricalcium phosphate powder is shown in fig. 2, the powder is in a porous structure, and the special porous structure can enable the tricalcium phosphate powder to form an interlocking structure with a polymer in the process of preparing the bone prosthesis. Fig. 3 shows a microscopic photograph of a bone prosthesis prepared by mixing the powder material and collagen and adding a crosslinking agent for reaction, and as can be seen from fig. 3, the micron-sized low-density porous tricalcium phosphate powder and collagen form an interpenetrating microstructure, the micron-sized low-density porous tricalcium phosphate powder remarkably improves the binding property with the collagen, and the problems of falling and inflammation of the nano tricalcium phosphate powder in the application process are solved.

Example 2

Weighing and dissolving 1800g of anhydrous calcium chloride and 400g of magnesium chloride hexahydrate, dissolving in 20L of water to obtain a solution A, weighing 1700g of diammonium phosphate, dissolving in 20L of water, and regulating the pH value of the solution to 9.8 by using ammonia water to obtain a solution B.

Heating and mixing, namely heating the solution A and the solution B to 90 ℃ and mixing, and continuously stirring at a rotating speed of 100rpm to form a suspension.

Wet chemical reaction the mixed suspension was heated at 90 ℃ for 4 hours at 100 rpm.

Spray drying, namely adding the cleaned precipitate into 20L of water, and stirring uniformly to form slurry. Setting the air inlet temperature of a spray dryer to be 270 ℃ and the air outlet temperature to be 140 ℃, and spray-drying the slurry at the speed of 100mL/min to finally obtain the micron-sized low-density porous tricalcium phosphate powder, wherein the particle size distribution is in the range of 1-20 mu m.

The X-ray diffraction result of the micron-sized low-density porous tricalcium phosphate powder is shown in figure 4, wherein the mass percentage of magnesium element is 1.3%.

Comparative example 1

Weighing and dissolving 1800g of anhydrous calcium chloride and 300g of magnesium chloride hexahydrate, dissolving in 20L of water to obtain a solution A, weighing 1700g of diammonium phosphate, dissolving in 20L of water, and regulating the pH value of the solution to 9.3 by using ammonia water to obtain a solution B.

Spray drying, namely adding the cleaned precipitate into 20L of water, and stirring uniformly to form slurry. Setting the air inlet temperature of a spray dryer to be 270 ℃ and the air outlet temperature to be 140 ℃, and spray-drying the slurry at the speed of 100mL/min to finally obtain the micron-sized low-density porous tricalcium phosphate powder.

The X-ray diffraction result of tricalcium phosphate powder is shown in figure 5. As shown in fig. 5, the porous tricalcium phosphate powder contains an impurity phase, mainly calcium hydrogen phosphate impurity phase.

Comparative example 2

The procedure of comparative example 2 was different from that of example 2 in that the pH of the solution was adjusted to 10.8 with ammonia water after dissolving diammonium phosphate in water, and the other steps were the same.

XRD detection was performed on the obtained powder material, and the powder material obtained in comparative example 2 contained a large amount of hydroxyapatite based on the X-ray diffraction result shown in FIG. 6.

As used in this specification and in the claims, the terms "comprises" and "comprising" merely indicate that the steps and elements are explicitly identified, and do not constitute an exclusive list, as other steps or elements may be included in a method or apparatus. The term "and/or" as used herein includes any combination of one or more of the associated listed items.

The endpoints and any values of the ranges disclosed herein are not limited to the precise range or value, and are understood to encompass values approaching those ranges or values. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and are to be considered as specifically disclosed herein.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. If a definition used herein contradicts or is inconsistent with a definition set forth in other publications, the definition used herein should prevail.

The above-described embodiments are provided for illustrating the technical concept and features of the present invention, and are intended to be preferred embodiments for those skilled in the art to understand the present invention and implement the same according to the present invention, not to limit the scope of the present invention. All equivalent changes or modifications made according to the principles of the present invention should be construed to be included within the scope of the present invention.

Claims

1. A method for preparing a porous magnesium-containing tricalcium phosphate bone repair raw material, characterized in that it comprises the following steps:

(i) preparing a mixed solution of calcium salt and magnesium salt as a first solution; preparing a phosphate solution and adjusting the pH to 9.8-10.2 with an alkali solution as a second solution;

(ii) heating and mixing the first solution and the second solution, and reacting them at 60-95° C. with stirring; wherein the first solution and the second solution are mixed in equal volumes;

(iii) The suspension obtained after the reaction in step (ii) is centrifuged to separate the precipitate, which is then washed and spray-dried to obtain a powdery porous magnesium-containing tricalcium phosphate porous bone repair material.

2. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair raw material according to claim 1, characterized in that the molar ratio of calcium ions to magnesium ions in the first solution is 6 to 10.

3. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair material according to claim 2, characterized in that the molar concentration of calcium ions in the first solution is 0.01~0.9 mol/L, and the molar concentration of magnesium ions is 0.001~0.15 mol/L.

4. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair material according to any one of claims 1 to 3, characterized in that after the first solution and the second solution are mixed, the molar ratio of calcium ions to phosphate ions is 1.1 to 1.5.

5. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair material according to claim 4, characterized in that the molar concentration of phosphate in the second solution is 0.008-0.8 mol/L.

6. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair raw material according to any one of claims 1 to 3, characterized in that the calcium salt is selected from a combination of one or more of anhydrous calcium chloride, calcium chloride dihydrate and calcium nitrate tetrahydrate, the magnesium salt is selected from magnesium chloride hexahydrate and/or magnesium nitrate hexahydrate, the phosphate is selected from a combination of one or more of disodium hydrogen phosphate, diammonium hydrogen phosphate and sodium hydrogen phosphate, and the alkali solution is ammonia water or sodium hydroxide.

7 . The method for preparing a porous magnesium-containing tricalcium phosphate bone repair material according to claim 1 , wherein in step (i), ammonia water is used to adjust the pH of the second solution to 9.8-10.2.

8 . The method for preparing the porous magnesium-containing tricalcium phosphate bone repair material according to claim 1 , characterized in that in step (ii), the first solution and the second solution are heated to 60-95° C. and then mixed.

9 . The method for preparing the porous magnesium-containing tricalcium phosphate bone repair material according to claim 1 or 8 , characterized in that in step (ii), the stirring rate is 100-500 rpm.

10. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair material according to claim 1, characterized in that in step (iii), a spray dryer is used to spray dry the washed precipitate, the inlet air temperature of the spray dryer is 240-300°C, the outlet air temperature is 120-150°C, and the feed rate is 30-200 mL/min.

11. The method for preparing a porous magnesium-containing tricalcium phosphate bone repair material according to claim 1 or 10, characterized in that in step (iii), the precipitate is added to water and centrifuged and washed multiple times, the washed precipitate is added to 5 to 20 times the mass of water, stirred evenly to form a slurry, and then spray-dried.

12. The method for preparing the porous magnesium-containing tricalcium phosphate bone repair material according to claim 1, characterized in that the preparation method is specifically implemented as follows:

Dissolving a calcium salt and a magnesium salt in water to obtain a first solution, wherein the concentration of the calcium salt is 1-100 g/L, and the concentration of the magnesium salt is 0.4-40 g/L;

Dissolving phosphate in water, and adjusting the pH to 9.8-10.2 with aqueous ammonia to obtain a second solution, wherein the concentration of phosphate is 1-100 g/L;

The first solution and the second solution of equal volume are heated to 60-95°C and then mixed, and reacted under normal pressure with stirring, wherein the stirring rate is 100-500 rpm;

The suspension after the reaction is centrifuged to obtain a precipitate, which is centrifugally washed with water for 4 to 8 times, and the washed precipitate is added to 5 to 20 times the mass of water, stirred evenly to form a slurry, and the slurry is processed into a micron-sized porous magnesium-containing tricalcium phosphate powder using a spray dryer to obtain the porous magnesium-containing tricalcium phosphate bone repair raw material, wherein the inlet temperature of the spray dryer is 240 to 300 ° C, the outlet temperature is 120 to 150 ° C, and the feed rate is 30 to 200 mL/min.