CN117902537A - A high-viscosity liquid medicine filling system and filling process - Google Patents

Abstract

The present invention belongs to the field of biopharmaceutical technology, and specifically relates to a high-viscosity liquid medicine filling system and filling process, wherein the system includes a driving component for driving an extrusion component to move back and forth; an extrusion component for extruding an infusion tube so that the liquid medicine is transported in the infusion tube; an infusion tube for transporting the liquid medicine to a filling position; and a tube clamping component, which is arranged at a position of the infusion tube near a liquid outlet and is used to clamp the infusion tube. The present invention realizes the transportation and filling of liquid medicine through the reciprocating motion of two rollers. There is no ceramic plunger pump, no glass pump, no peristaltic pump, no one-way valve in the entire filling system, only a liquid medicine pipeline, which is simple to install, easy to maintain, and has low risk of use. At the same time, the tube clamping component is combined to clamp or loosen the infusion tube to control the outflow or back-absorption of liquid medicine during the filling process, and the filling accuracy is high. The filling accuracy of high-viscosity liquid medicine can reach ±3%, and its direct economic benefit can increase the drug yield by about 1-2 percentage points.

Description

A high-viscosity liquid medicine filling system and filling process

Technical Field

The present invention belongs to the field of biopharmaceutical technology, and specifically relates to a high-viscosity liquid medicine filling system and a filling process, which can be used not only for the filling of common medicines, but also for the large-scale and continuous filling of high-viscosity medicines, such as DNA vaccine preparations.

Background technique

We use a DNA plasmid platform for the development and large-scale production of DNA vaccine products. Due to the high viscosity of DNA plasmids and the problems of small filling volume and high filling precision requirements of this product, in the preparation process, in addition to solving the general process problems of sterile preparations, we also need to overcome the technical difficulties of high viscosity, low filling volume and high-precision liquid filling while ensuring that all indicators such as sterility are qualified.

The traditional systems for liquid filling include filling forms driven by peristaltic pumps and filling forms driven by ceramic plunger pumps. Both filling forms cannot be applied to the filling of high-viscosity, low-volume, and high-precision liquid medicines. The filling form driven by peristaltic pumps, such as a peristaltic pump filling machine disclosed in the prior art CN213356926U, includes a material box, a filling pump and a filling head. The filling liquid in the material box is transported to the filling head through the filling pump; the filling pump is a peristaltic pump, the input interface of the peristaltic pump is connected to the material box, and the output interface of the peristaltic pump is connected to the filling head; the peristaltic pump is provided with a rotor and a pump tube. There are multiple rollers on the rotor. When the rotor rotates, a section of the pump tube between the two rotating rollers forms a "pillow"-shaped fluid, and the fluid is squeezed out of the peristaltic pump. When this filling form is used for high-viscosity liquid filling, the force of the peristaltic pump rotation cannot be transmitted to the liquid outlet in time, resulting in less or more liquid output and a large accuracy deviation.

The filling form driven by a ceramic plunger pump, such as a valveless ceramic plunger pump filling machine disclosed in the prior art CN104890909A, includes a chassis part and a valveless ceramic plunger pump part, which are fixedly combined by a motor fixing bracket, and the quick-install metering and regulating valveless ceramic plunger pump is organically combined with the automatic control technology to form an independent liquid filling device. The plunger reciprocates back and forth in the pump body, which can change the volume of the sealed working chamber, thereby achieving the purpose of suction and discharge, which is the same as the principle of the syringe. During the reciprocating motion of the plunger, it is easy to generate shear force on the DNA liquid, and when filling the high-viscosity DNA liquid, this force is difficult to control the discharge of the high-viscosity DNA liquid, which is easy to cause the pump to get stuck. There is no auxiliary device to coordinate the control of liquid outflow, and the controllable range of liquid outflow is narrow, and the accuracy is relatively low.

In summary, the present invention provides a high-viscosity liquid medicine filling system and filling process.

Summary of the invention

In order to solve the technical problem that the filling accuracy of high-viscosity liquid medicine is difficult to control using the filling system in the prior art, the present invention provides a high-viscosity liquid medicine filling system and a filling process.

To achieve the above object, the technical solution of the present invention is as follows:

A high-viscosity liquid medicine filling system, comprising:

A driving assembly, used for driving the extrusion assembly to move back and forth;

An extrusion assembly is used to squeeze the infusion tube so that the medicine solution is transported in the infusion tube;

Infusion tube, used to transport liquid medicine to the filling position;

The tube clamping assembly is arranged at a position of the infusion tube close to the liquid outlet, and is used to clamp the infusion tube and control the outflow or back suction of the liquid medicine inside the infusion tube.

Furthermore, the extrusion assembly includes two rollers, which are symmetrically arranged on both sides of the infusion tube, and the distance between the two rollers is smaller than the outer diameter of the infusion tube; the driving assembly drives the rollers to reciprocate along the length direction of the infusion tube, and the rollers squeeze the infusion tube to achieve the delivery of the medicine.

Furthermore, the distance between the two rollers is twice the wall thickness of the infusion tube.

Furthermore, the tube clamping assembly includes a motor, a transmission component and a tube clamping component, the motor drives the tube clamping component to move through the transmission component, the tube clamping component includes a fixed block and a movable block, the infusion tube is clamped in the tube clamping component, and the motor drives the movable block to approach the fixed block or move away from the fixed block through the transmission component to achieve clamping or loosening.

Furthermore, the number of the motor and the number of the transmission member are both one, the number of the tube clamping members is plural, and one motor drives all the tube clamping members to move through one transmission member.

Furthermore, the movable block includes a base, two limit columns are arranged on one side of the base, and a gap is provided between the two limit columns for the infusion tube to pass through; a clamping block is arranged in the middle above the base, and an open circular hole is arranged inside the clamping block for the infusion tube to pass through; a stop block is arranged on the other side above the base.

Furthermore, the fixing block is arranged close to the stop block.

Furthermore, the tube clamping assembly also includes a fixed frame, which is a hollow member, and the transmission component is arranged inside the fixed frame; a plurality of openings are arranged on the upper side wall of the fixed frame; the movable block is arranged above the fixed frame, and a connecting block is arranged below the movable block, the connecting block passes through the opening to connect the transmission component, and the fixed block is arranged on the outer side of the side wall of the fixed frame.

Furthermore, the transmission component includes a crankshaft and a reciprocating rod connected to the crankshaft, one end of the crankshaft is connected to the motor, the other end of the crankshaft is connected to the reciprocating rod, and the reciprocating rod is arranged inside the fixing frame and connected to the connecting block.

Furthermore, the number of the motor, the transmission component, and the tube clamping component is one or more, and the number of the motor, the transmission component, and the tube clamping component is the same; one motor drives one tube clamping component through one transmission component.

Furthermore, the fixed block includes a fixed plate, and a plurality of hooks for the infusion tube to pass through are arranged on the side surface of the fixed plate; the movable block is arranged near the middle of the fixed plate.

Furthermore, the tube clamping member further comprises an upper fixing plate and a lower fixing plate, the motor is arranged between the upper fixing plate and the lower fixing plate; the motor is connected to the transmission member, and the transmission member passes through the upper fixing plate to connect to the movable block.

Furthermore, the transmission component includes a crankshaft, one end of the crankshaft is connected to the motor, and the other end of the crankshaft is connected to the movable block.

The present invention also provides a high-viscosity liquid medicine filling process, using the above-mentioned high-viscosity liquid medicine filling system, comprising:

S1. After the preparation of the liquid medicine to be filled is completed, it enters the sterilization filtration process for sterilization filtration;

S2. While the liquid medicine is being sterilized and filtered, the vials, rubber stoppers and aluminum caps required for filling are cleaned and sterilized;

S3, the liquid medicine enters the filling process after sterilization and filtration, and is filled using the above-mentioned high-viscosity liquid medicine filling system;

S4, after the liquid medicine is filled, the cap is rolled to form a rolled cap intermediate product;

S5. Remove defective products from intermediate products through the light inspection process;

S6. Pack qualified products and put them into storage.

Compared with the prior art, the present invention has the following beneficial effects:

The present invention realizes the conveying and filling of liquid medicine through the reciprocating motion of two rollers. The entire filling system has no ceramic plunger pump, no glass pump, no peristaltic pump, no one-way valve, and only liquid medicine pipelines. The installation is simple, the maintenance is convenient, and the use risk is low.

The present invention drives the delivery of liquid medicine by means of roller squeezing the infusion tube to realize filling, and at the same time combines with the tube clamping component to clamp or loosen the infusion tube to control the outflow or back suction of liquid medicine during the filling process, and the tube clamping component design in which a motor drives a tube clamping component through a transmission component can independently adjust a single tube clamping component to perform mechanical back suction control on liquid medicine, and during operation, the liquid discharges of the filling needles of each liquid medicine hose do not affect each other, and the filling accuracy is high. The filling accuracy of high-viscosity liquid medicine can reach ±3%, and its direct economic benefit can increase the drug yield by about 1-2 percentage points.

The entire pipeline of the present invention is completely visible, and the liquid medicine hose is placed between two movable rollers, which is very convenient for installation and removal. It can be operated with one hand wearing isolation gloves, avoiding the shortcomings of ceramic plunger pump installation and removal, and simplifying the operation of ordinary peristaltic pumps that need to open the pump cover to align the pipeline. The production auxiliary time is reduced by more than 30 minutes per day.

In the present invention, a hose is connected from the dispenser or the liquid medicine storage bag to the filling needle, with no valve in the middle and no sanitary dead corner; the liquid does not contact any other medium except the hose and the 316L stainless steel joint, which greatly avoids the risk of cross contamination and reduces the cleaning and disinfection time.

Since the present invention does not use traditional peristaltic pumps and ceramic pumps, it has good precision and stability. Traditional peristaltic pumps generally require fine-tuning once every 30 minutes, while the present invention basically does not require fine-tuning during a stable production process, and only needs to adjust the loading amount at the beginning and end of production.

The hose of the present invention has a long service life, which is more than 10 times that of an ordinary peristaltic pump. Generally, one hose can be squeezed 400,000 times. The symmetrical double roller tube pressing design is adopted, and the tube only needs to be pressed once for each filling, which greatly reduces the wear of the hose; the linear reciprocating motion mode minimizes the number of tube pressing times, releases the recovery time of the hose elasticity, and increases the service life of the hose.

The present invention has high filling accuracy and a wide application range. From 0.03 ml to 30 ml, only one set of pumpless device and corresponding hose are needed, while the ceramic plunger pump needs to be equipped with plunger pumps and hoses of different specifications.

The present invention will not cause the pump to get stuck, and will not cause the pump to get stuck for fluids that are easy to crystallize and have high viscosity, thereby reducing production risks and use costs.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a structural block diagram of the present invention.

FIG. 2 is a schematic diagram of the structure of the extrusion assembly in the first embodiment of the present invention.

FIG. 3 is a schematic structural diagram of a tube clamping assembly in Embodiment 1 of the present invention.

FIG. 4 is a schematic structural diagram of a tube clamping assembly in a second embodiment of the present invention.

FIG5 is a process flow chart of the third embodiment of the present invention.

Description of reference numerals:

1-driving assembly, 2-roller, 3-infusion tube, 4'-tube clamp assembly, 5-medicine storage bag,

401-motor, 402-fixed block, 403-movable block, 4301-base, 4302-limiting column, 4303-clamping block, 4304-stopper, 404-fixed frame, 405-crankshaft, 406-reciprocating rod,

6-upper fixed plate, 7-lower fixed plate, 401'-motor, 402'-fixed block, 4201'-fixed plate, 4202'-hook, 403'-movable block, 8-filling needle, 9-support.

Detailed ways

The technical solution of the present invention will be clearly described below in conjunction with the accompanying drawings. Obviously, the described embodiments are not all embodiments of the present invention, and all other embodiments obtained by ordinary technicians in the field without making creative work are within the protection scope of the present invention.

It should be noted that the directions or positional relationships indicated by terms such as “center”, “up”, “down”, “left”, “right”, “vertical” and “horizontal” are based on the directions or positional relationships shown in the accompanying drawings and are only for the convenience of describing the present invention and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention.

Embodiment 1

The present embodiment provides a high-viscosity liquid medicine filling system, including a driving component 1, which is used to drive the extrusion component to move back and forth; the extrusion component is used to squeeze the infusion tube 3 so that the liquid medicine is transported in the infusion tube 3; the infusion tube 3 is used to transport the liquid medicine to the filling position; and the tube clamping component is arranged at a position of the infusion tube near the liquid outlet, which is used to clamp the infusion tube to control the outflow or back suction of the liquid medicine inside the infusion tube.

As shown in FIG2 , the extrusion assembly includes two rollers 2, which are symmetrically arranged on both sides of the infusion tube 3, and the distance between the two rollers 2 is smaller than the outer diameter of the infusion tube 3; the driving assembly 1 drives the roller to roll back and forth along the length direction of the infusion tube, and the roller squeezes the infusion tube. The delivery of the liquid medicine is realized. Preferably, the distance between the two rollers is twice the wall thickness of the infusion tube. The driving assembly drives the roller 2 to roll back and forth up and down by using the existing technology, for example, the driving assembly includes a cylinder, the protruding shaft of the cylinder is connected to a slider, the slider is restricted to move up and down, the roller is arranged on the slider, the roller is connected to the slider through a rotating shaft, and the roller can rotate along the rotating shaft. During the reciprocating movement of the cylinder up and down, the cylinder can drive the slider to move up and down, and the slider drives the roller to move up and down through the rotating shaft. Since the roller can rotate along the rotating shaft, the roller is affected by the friction force on the surface of the infusion tube, and the roller rolls up and down along the infusion tube to achieve the purpose of squeezing the infusion tube. As the roller moves upward, negative pressure is formed inside the infusion tube below the roller, sucking the liquid medicine in the liquid medicine storage bag into the infusion tube. The liquid medicine inside the infusion tube above the roller is transported to the filling needle and flows out with the squeezing of the roller, thus completing the filling. The amount of liquid medicine discharged can be controlled by controlling the moving distance of the roller.

The tube clamping assembly includes a motor 401, a transmission component and a tube clamping component. The motor 401 drives the tube clamping component to move through the transmission component. The tube clamping component includes a fixed block 402 and a movable block 403. The infusion tube 3 is clamped in the movable block 403. The motor 401 drives the movable block 403 to move closer to or away from the fixed block 402 through the transmission component to achieve clamping or loosening.

In this embodiment, the number of the motor 401 and the number of the transmission components are both one, the number of the tube clamping components is 5, and one motor 401 drives all the tube clamping components to move through one transmission component, wherein the number of the tube clamping components can be increased or decreased as needed.

The movable block 403 includes a base 4301, two limiting columns 4302 are arranged on one side of the base 4301, and there is a gap between the two limiting columns 4302 for the infusion tube 3 to pass through; a clamping block 4303 is arranged in the middle above the base 4301, and an open circular hole is arranged inside the clamping block 4303 for the infusion tube 3 to pass through; a stopper 4304 is arranged on the other side above the base 4301. The fixed block 402 is arranged close to the stopper 4304. The clamping tube assembly also includes a fixed frame 404, which is a hollow member, and the transmission member is arranged inside the fixed frame 404; a plurality of openings are arranged on the upper side wall of the fixed frame 404; the movable block 403 is arranged above the fixed frame 404, and a connecting block (blocked in the figure) is arranged below the movable block 403, and the connecting block passes through the opening to connect the transmission member, and the fixed block 402 is arranged on the outer side of the side wall of the fixed frame 404.

The transmission component includes a crankshaft 405 and a reciprocating rod 406 connected to the crankshaft 405. One end of the crankshaft 405 is connected to the motor 401, and the other end of the crankshaft 405 is connected to the reciprocating rod 406. The reciprocating rod 406 is arranged inside the fixing frame 404 and connected to the connecting block.

A filling needle 8 is provided at the end of the infusion tube 3 for filling. A section of the infusion tube 3 close to the filling needle 8 passes through the gap of the limiting column 4302, the circular hole of the clamping block 4303, and the gap between the stopper 4304 and the fixed block 402 in sequence. The limiting column 4302 and the clamping block 4303 are used to fix the infusion tube 3, and the stopper 4304 and the fixed block 402 are used to clamp or loosen the infusion tube 3. When the filling is completed, the motor 401 starts to rotate, and the motor 401 drives the crankshaft 405 to rotate. The crankshaft 405 drives the reciprocating rod 406 to move in the fixed frame 404. The movement of the reciprocating rod 406 drives the movable block 403 to move toward the direction close to the motor 401, so that the stopper 4304 is close to the fixed block 402, squeezing the infusion tube 3 to prevent the liquid from flowing out or being sucked back. When the filled product is removed and the next round of filling is required, the motor 401 reverses and drives the crankshaft 405 to rotate in the opposite direction. The crankshaft 405 drives the reciprocating rod 406 to move in the fixed frame 404. The movement of the reciprocating rod 406 drives the movable block 403 to move away from the motor 401, so that the stopper 4304 moves away from the fixed block 402, loosens the infusion tube 3, and resumes normal infusion.

In this embodiment, the design of the tube clamping assembly in which one motor drives multiple tube clamping components through a transmission component cannot independently adjust a single tube clamping component to control the mechanical back suction of the medicine solution. During operation, there is an impact on the liquid output of each medicine liquid hose filling needle. When there is no bottle to be filled, the filling accuracy of the unfilled medicine liquid pipeline will fluctuate, and affect the filling accuracy of the filled medicine liquid pipeline.

Embodiment 2

The present embodiment provides a high-viscosity liquid medicine filling system, as shown in FIG1 , comprising a driving assembly 1 for driving an extrusion assembly to reciprocate; an extrusion assembly for extruding an infusion tube 3 so that the liquid medicine is transported in the infusion tube 3; the infusion tube 3 for transporting the liquid medicine to a filling position; and a tube clamping assembly disposed at a position of the infusion tube 3 near the liquid outlet, for clamping the infusion tube 3 to control the outflow or reabsorption of the liquid medicine inside the infusion tube 3.

In this embodiment, the driving assembly 1, the squeezing assembly, and the infusion tube 3 all adopt the same structure as in the first embodiment. The tube clamping assembly includes a motor 401', a transmission member, and a tube clamping member. The motor 401' drives the tube clamping member to move through the transmission member. The tube clamping member includes a fixed block 402' and a movable block 403'. The infusion tube 3 is clamped in the fixed block 402'. The motor 401' drives the movable block 403' to rotate left and right through the transmission member so that the movable block 403' is close to the fixed block 402' or away from the fixed block 402', thereby achieving clamping or loosening.

In this embodiment, the number of the motors 401', the transmission components, and the tube clamping components are all 8, which can also be increased or decreased according to actual needs, but the number of the motors 401', the transmission components, and the tube clamping components are the same; one motor 401' drives one tube clamping component through one transmission component.

The fixed block 402' includes a fixed plate 4201', and a plurality of hooks 4202' are arranged on the side surface of the fixed plate 4201' for the infusion tube to pass through; the movable block 403' is arranged near the middle of the fixed plate 402'. The tube clamping member also includes an upper fixed plate 6 and a lower fixed plate 7, and the upper fixed plate 6 and the lower fixed plate 7 are fixedly connected on both sides by a vertical plate, and the lower fixed plate 7 is fixedly arranged by a support 9; the motor 401' is arranged between the upper fixed plate 6 and the lower fixed plate 7; the motor 401' is connected to the transmission member, and the transmission member passes through the upper fixed plate 6 and is connected to the movable block 403'.

Specifically, the transmission component includes a crankshaft (blocked in the figure), one end of the crankshaft is connected to the motor 401 ′, and the other end of the crankshaft is connected to the movable block 403 ′.

A filling needle 8 is provided at the end of the infusion tube 3 for filling. A section of the infusion tube 3 near the filling needle 8 passes through the hook 4202', the gap between the movable block 403' and the fixed plate 402', and the hook 4202' in sequence. The hook 4202' is used to fix the infusion tube 3, and the movable block 403' and the fixed plate 4201' are used to clamp or loosen the infusion tube 3. When the filling is completed, the motor 401' starts to rotate, the motor 401' drives the crankshaft to rotate, and the crankshaft drives the movable block 403' to move in the direction close to the fixed plate 4201', squeezes the infusion tube, and prevents the liquid from flowing out or sucking back. When the filled product is removed and the next round of filling is required, the 401' motor reverses, drives the crankshaft to rotate in the opposite direction, and the crankshaft drives the movable block 403' to move in the direction away from the fixed plate 4201', so that the movable block 403' is away from the fixed plate 4201', loosens the infusion tube 3, and resumes normal infusion.

The filling system of this embodiment was used to perform a filling test. The filling liquid was 500ML of DNA vaccine liquid with a viscosity of 85CPs. Five filling needles were used to test 47 sets of valid data with a standard filling volume of 0.5g. The test data are shown in Table 1. Through data analysis, the pumpless filling system of this embodiment can meet the production requirements of low filling volume, high precision and good stability. The filling accuracy of high-viscosity liquid medicine can reach ±3%.

Table 1 Test data of Example 2

In this embodiment, a tube clamping assembly design in which a motor drives a tube clamping member through a transmission member can independently adjust a single tube clamping member to perform mechanical back suction control on the drug solution. During operation, the liquid outputs of the filling needles of each drug solution hose do not affect each other, and the filling accuracy is high.

Embodiment 3

This embodiment is a high-viscosity liquid filling process, using the high-viscosity liquid filling system of the above embodiment, including:

S1. After the liquid medicine to be filled is prepared, it enters the sterilization and filtration process for sterilization and filtration;

S2. While the liquid medicine is being sterilized and filtered, the vials, rubber stoppers and aluminum caps required for filling are cleaned and sterilized;

S3, the liquid medicine enters the filling process after sterilization and filtration, and is filled using the above-mentioned high-viscosity liquid medicine filling system;

S4, after the liquid medicine is filled, the cap is rolled to form a rolled cap intermediate product;

S5. Remove defective products from the intermediate products through the light inspection process. Defective products include defective products such as poor capping, abnormal filling, scratches, and cracked bottles;

S6. Pack qualified products and put them into storage.

The above specific implementation methods are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to examples, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced by equivalents without departing from the scope of the technical solutions of the present invention, which should be included in the scope of the claims of the present invention.

Claims (10)

1. A high viscosity medical fluid filling system, comprising:

The driving assembly is used for driving the extrusion assembly to reciprocate;

The extrusion assembly is used for extruding the infusion tube so that the liquid medicine is conveyed in the infusion tube;

The infusion tube is used for conveying the liquid medicine to the filling position;

The clamping pipe assembly is arranged at the position, close to the liquid outlet, of the infusion pipe and is used for clamping the infusion pipe and controlling the outflow or the back suction of the liquid medicine in the infusion pipe.

2. The high viscosity medical fluid filling system according to claim 1, wherein the extrusion assembly comprises two rollers symmetrically arranged on both sides of the infusion tube, and the distance between the two rollers is smaller than the outer diameter of the infusion tube; the driving assembly drives the rollers to roll reciprocally along the length direction of the infusion tube, the rollers squeeze the infusion tube to realize the conveying of liquid medicine, and preferably, the distance between the two rollers is 2 times the wall thickness of the infusion tube.

3. The high-viscosity medical fluid filling system according to claim 1, wherein the tube clamping assembly comprises a motor, a transmission member and a tube clamping member, the motor drives the tube clamping member to act through the transmission member, the tube clamping member comprises a fixed block and a movable block, the infusion tube is clamped in the tube clamping member, and the motor drives the movable block to be close to the fixed block or far from the fixed block through the transmission member so as to realize clamping or loosening;

Preferably, the number of the motors and the transmission members is one, the number of the pipe clamping members is a plurality of the motor, and one motor drives all the pipe clamping members to act through one transmission member;

Or the number of the motors, the transmission members and the pipe clamping members is one or more, and the number of the motors, the transmission members and the pipe clamping members is the same; a motor drives a clamp tube member through a transmission member.

4. The high-viscosity liquid medicine filling system according to claim 3, wherein the movable block comprises a base, two limit posts are arranged on one side of the base, and a gap for a transfusion tube to pass through is arranged between the two limit posts; the middle part above the base is provided with a clamping block, and an opening round hole for the infusion tube to pass through is formed in the clamping block; a stop block is arranged on the other side above the base; the fixed block is arranged close to the stop block.

5. The high viscosity medical fluid filling system according to claim 3, wherein the clip tube assembly further comprises a mount, the mount being a hollow piece, the drive member being disposed within the mount; a plurality of openings are formed in the side wall above the fixing frame; the movable block is arranged above the fixing frame, the connecting block is arranged below the movable block, the connecting block penetrates through the opening to be connected with the transmission member, and the fixing block is arranged on the outer side of the side wall of the fixing frame.

6. The high viscosity medical fluid filling system according to claim 5, wherein the transmission member comprises a crankshaft and a reciprocating rod connected with the crankshaft, one end of the crankshaft is connected with the motor, the other end of the crankshaft is connected with the reciprocating rod, and the reciprocating rod is arranged inside the fixing frame and connected with the connecting block.

7. The high-viscosity medical fluid filling system according to claim 3, wherein the fixing block comprises a fixing plate, and a plurality of hooks for the infusion tube to pass through are arranged on the side surface of the fixing plate; the movable block is arranged close to the middle of the fixed plate.

8. The high viscosity medical fluid filling system according to claim 7, wherein the tube clamping member further comprises an upper fixed plate, a lower fixed plate, the motor being disposed between the upper fixed plate and the lower fixed plate; the motor is connected with the transmission component, and the transmission component penetrates through the upper fixed plate to be connected with the movable block.

9. The high viscosity medical fluid filling system according to claim 8, wherein the transmission member comprises a crankshaft, one end of the crankshaft is connected to a motor, and the other end of the crankshaft is connected to the movable block.

10. A high viscosity medical fluid filling process employing the high viscosity medical fluid filling system of any one of claims 1-9, comprising:

s1, after the medicine liquid to be filled is prepared, entering a sterilization and filtration process for sterilization and filtration;

S2, cleaning and sterilizing the penicillin bottle, the rubber plug and the aluminum cover required by filling while performing the sterilization and filtration procedures of the liquid medicine;

S3, sterilizing and filtering the liquid medicine, and then filling the liquid medicine in a filling process by adopting the high-viscosity liquid medicine filling system;

S4, capping after the filling of the liquid medicine is completed, and forming a capping intermediate product;

s5, removing bad products in the intermediate products through a lamp inspection procedure;

And S6, packaging and warehousing the qualified products.