CN118059338B - Membrane oxygenator with efficient filtration - Google Patents

Abstract

The invention provides a membrane oxygenator with high-efficiency filtration, which comprises a shell and an oxygenation temperature changing module, wherein the upper part of the shell is provided with a blood inlet, an air outlet, a water inlet and a water outlet, and the lower part of the shell is provided with a bleeding port, an air inlet and an air outlet; the oxygenation temperature changing module is vertically arranged in the shell and comprises a second filter screen, an oxygen pressure membrane, a first filter screen and a temperature changing membrane which are sequentially stacked from bottom to top, the temperature changing membrane is communicated with the water inlet and the water outlet, the oxygen pressure membrane is communicated with the air inlet and the air outlet, and the aperture of the second filter screen is smaller than that of the first filter screen; blood enters the shell from the blood inlet nozzle, sequentially passes through the temperature changing film, the first filter screen, the oxygen pressing film and the second filter screen from top to bottom, flows out from the bleeding port, and gas in the shell is discharged from bottom to top through the exhaust port. The invention can achieve better filtering effect on the premise of not increasing excessive pressure drop and blood pre-charge.

Description

High efficiency filtration membrane oxygenator

Technical Field

The invention relates to the technical field of medical devices, in particular to a high-efficiency filtering membrane oxygenator.

Background Art

The extracorporeal circulation device used in clinical surgery is commonly known as an artificial lung, also known as an oxygenator. As a device for extracorporeal blood oxygenation, the oxygenator plays an important role in extracorporeal circulation (CPB) and extracorporeal membrane oxygenation (ECMO). During application, its main function is to convert oxygen-poor venous blood into oxygen-rich arterial blood, replacing the function of the lungs to meet the needs of patients during surgery.

Since there are emboli including bubbles and solid particles in the drawn blood, direct transfusion back into the human body can cause vascular embolism. Therefore, during extracorporeal circulation, in addition to using an oxygenator to perform gas exchange on the blood to maintain the patient's oxygen supply, a filter is also used to intercept emboli in the blood. The filter is a safety barrier for blood transfusion back into the human body. In the prior art, there is a design that integrates the filter and the oxygenator into one. For example, in an oxygenator structure where the blood flows from the inside to the outside, the filter is a filter mesh that wraps the outermost silk membrane of the oxygenator. In an oxygenator structure where the blood flows from the outside to the inside, the filter is a filter mesh that wraps the innermost silk membrane of the oxygenator.

However, for the oxygenator structure where blood flows from outside to inside, in order to meet the filtering requirements, the internal space of the oxygenator is usually enlarged to install a filter with a large enough area. However, this design expands the volume of the oxygenator and increases the blood pre-charge volume, and is not suitable for oxygenators used by infants and young children. For the oxygenator structure where blood flows from inside to outside, although the filter area is increased, the volume of the oxygenator does not need to be deliberately enlarged, but due to the different sizes of bubbles and particles mixed in the blood, in order to meet the filtering requirements, the filter mesh is usually designed to be very small, resulting in poor blood permeability. The pressure loss of blood increases sharply when it flows through the filter. The pressure loss of the oxygenator determines the maximum output capacity of the blood pump and the speed difference under the same flow rate. The greater the pressure loss of the oxygenator itself, the blood pump needs to maintain the flow at a higher speed, thereby aggravating blood damage. At the same time, the increase in blood flow rate shortens the contact time between blood and oxygen pressure membrane wire, reducing oxygenation efficiency. In addition, the increase in blood flow rate will also disperse large bubbles into small bubbles. The increase in small bubbles further weakens the permeability of blood at the filter. In view of the above situation, it is necessary to design an oxygenator with small pre-fill volume, small pressure loss and good filtration effect to meet the functional needs in critical emergency scenarios.

Summary of the invention

In view of the shortcomings of the prior art, the object of the present invention is to provide a high-efficiency filtration membrane oxygenator, which can achieve a better filtration effect without increasing excessive pressure drop, increasing the blood priming volume or directly reducing the blood priming volume.

The present disclosure provides a high-efficiency filtration membrane oxygenator, comprising:

The outer shell has a blood inlet, an air outlet, a water inlet and a water outlet at the upper part, and a blood outlet, an air inlet and an air outlet at the lower part;

an oxygenation temperature-variable module, vertically arranged in the housing, comprising a second filter, an oxygen pressure membrane, a first filter and a temperature-variable membrane stacked in sequence from bottom to top, the temperature-variable membrane communicating with the water inlet and the water outlet, the oxygen pressure membrane communicating with the air inlet and the air outlet, and the aperture of the second filter being smaller than the aperture of the first filter;

Blood enters the shell from the blood inlet, passes through the temperature-variable membrane, the first filter, the oxygen pressure membrane and the second filter in sequence from top to bottom, and then flows out from the bleeding port, and the gas in the shell is discharged from bottom to top through the exhaust port.

Optionally, the pore size of the first filter is 70 μm to 100 μm; and the pore size of the second filter is not greater than 40 μm.

Optionally, a blood dispersion structure is provided on the top of the shell, and the blood inlet is connected to the blood dispersion structure, and the blood dispersion structure is used to disperse the blood entering from the blood inlet to the upper surface of the temperature variable membrane.

Optionally, the blood dispersion structure includes a buffer space and a plurality of spoilers arranged around the buffer space, the buffer space is located in the middle area of the top of the outer shell, the blood inlet is connected to the buffer space, the spoilers extend from the buffer space to the inner wall of the outer shell, and a drainage channel is formed between two adjacent spoilers; after the blood enters the buffer space from the blood inlet, the blood is dispersed along the drainage channel to the upper surface of the temperature variable membrane.

Optionally, the cross-section of the buffer space is circular, the blood inlet nozzle is tangent to the buffer space, and the blood enters the buffer space tangentially to form a spiral vortex in the buffer space.

Optionally, the exhaust port is arranged at the top of the shell, and the exhaust port is connected to the buffer space.

Optionally, the exhaust port is higher than the highest position of the buffer space.

Optionally, the oxygenator further comprises a blocking layer, a transverse isolation layer and a longitudinal isolation layer, the blocking layer is arranged between the inner side wall of the shell and the oxygenation temperature-changing module, a circulation space is provided between the inner side wall of the shell and the blocking layer, the transverse isolation layer and the longitudinal isolation layer are arranged in the circulation space, and the transverse isolation layer divides the circulation space into a water channel space and a gas channel space, and the longitudinal isolation layer divides the water channel space into a first water channel space and a second water channel space, and divides the gas channel space into a first gas channel space and a second gas channel space;

The water inlet is connected to the first water path space, the water outlet is connected to the second water path space, the air inlet is connected to the first air path space, and the air outlet is connected to the second air path space;

The inlet of the temperature variable membrane passes through the blocking layer to communicate with the first water path space, and the outlet passes through the blocking layer to communicate with the second water path space. The inlet of the oxygen pressure membrane passes through the blocking layer to communicate with the first air path space, and the outlet passes through the blocking layer to communicate with the second air path space.

Optionally, the outer shell includes a shell body, an upper cover arranged at an opening on the top of the shell body, and a lower cover arranged at an opening on the bottom of the shell body, the blood inlet nozzle and the blood dispersion structure are arranged on the upper cover, the bleeding port is arranged on the lower cover, the water inlet and the water outlet are arranged on a side of the shell body close to the upper cover, the air inlet and the air outlet are arranged on a side of the shell body close to the lower cover, and the oxygenation temperature variable module is arranged in the shell body.

Optionally, the cross-section of the oxygenation temperature-variable module is rectangular, and the height of the oxygenation temperature-variable module is smaller than the minimum value of the length and width of the oxygenation temperature-variable module.

The implementation of the above scheme has the following beneficial effects:

The oxygenator disclosed in the present invention includes a second filter, an oxygen pressure membrane, a first filter and a variable temperature membrane which are stacked in sequence from bottom to top. The aperture of the second filter is smaller than that of the first filter. Blood enters the oxygenator from the blood inlet, passes through the variable temperature membrane, the first filter, the oxygen pressure membrane and the second filter in sequence from top to bottom, and then flows out from the bleeding outlet. By setting the first filter and the second filter, the filtering area of the oxygenator is increased, and a better filtering effect can be achieved. In addition, since the filtering area is large enough, it is not necessary to make the first filter and the second filter into a pleated shape that occupies a large space, thereby not increasing the internal space occupied by the oxygenator, and also not increasing the blood priming amount.

In this structural design, blood flows from top to bottom with good fluidity. Even if the first filter and the second filter are added on the basis of the variable temperature membrane and the oxygen pressure membrane, the pressure loss will not increase significantly. In addition, the aperture of the first filter is larger than the aperture of the second filter, and the resistance of the first filter is smaller than the resistance of the second filter. The blood first passes through the first filter and then the second filter, and the blood permeability will not be significantly weakened. In addition, the first filter intercepts larger bubbles and impurities on the side of the variable temperature membrane, which can improve the permeability of blood when passing through the oxygen pressure membrane, reduce the filtering pressure of the second filter, and improve the permeability of blood at the second filter.

In summary, the present invention can achieve a better filtering effect without increasing the pressure drop and blood priming volume. The oxygenator disclosed in the present invention has a small blood priming volume and is particularly suitable for infants and young children who are sensitive to the blood priming volume.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic structural diagram of a high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG2 is a top view of a high efficiency filtration membrane oxygenator disclosed in the present invention;

FIG3 is a cross-sectional view of a high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG4 is a schematic structural diagram of the upper cover of the high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG5 is a schematic structural diagram of the upper cover of the high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG6 is a cross-sectional view of a high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG7 is a schematic diagram of the blood circuit structure of the high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG8 is a schematic diagram of the water circuit structure of the high-efficiency filtration membrane oxygenator disclosed in the present invention;

FIG. 9 is a schematic diagram of the gas path structure of the high-efficiency filtration membrane oxygenator disclosed in the present invention.

In the figure:

100 housing, 101 housing, 102 upper cover, 103 lower cover, 104 blood inlet, 105 bleeding outlet, 106 water inlet, 107 water outlet, 108 air inlet, 109 air outlet, 110 air outlet, 111 first water path space, 112 second water path space, 113 first air path space, 114 second air path space,

200 oxygenation temperature-variable module, 201 temperature-variable membrane, 202 first filter, 203 oxygen pressure membrane, 204 second filter, 205 buffer space, 206 spoiler,

300 blocking layer, 301 transverse isolation layer, 302 longitudinal isolation layer.

DETAILED DESCRIPTION

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

In the description of the present invention, it should be noted that the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or are the positions or positional relationships in which the inventive product is usually placed when in use. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "disposed" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

The present embodiment provides a high-efficiency filtration membrane oxygenator, comprising a housing 100 and an oxygenation temperature-variable module 200 disposed in the housing 100. Referring to Figs. 1 to 6, the upper portion of the housing 100 is provided with a blood inlet 104, an exhaust port 110, a water inlet 106 and a water outlet 107, and the lower portion of the housing 100 is provided with a bleeding port 105, an air inlet 108 and an air outlet 109. The oxygenation temperature-variable module 200 is vertically disposed in the housing 100, and comprises a second filter screen 204, an oxygen pressure membrane 203, a first filter screen 202 and a temperature-variable membrane 201 which are sequentially stacked from bottom to top, the temperature-variable membrane 201 connecting the water inlet 106 and the water outlet 107, the oxygen pressure membrane 203 connecting the air inlet 108 and the air outlet 109, and the aperture of the second filter screen 204 is smaller than the aperture of the first filter screen 202. When in use, blood enters the housing 100 from the blood inlet 104, passes through the temperature variable membrane 201, the first filter 202, the oxygen pressure membrane 203 and the second filter 204 from top to bottom, and then flows out from the bleeding port 105, and the gas in the housing 100 is discharged from bottom to top through the exhaust port 110.

Among them, the first filter 202 and the second filter 204 can be a plane filter or a pleated filter. Of course, the plane filter can reduce the space occupied, which is beneficial to reduce the blood pre-filling volume, while the pleated filter can increase the filtration area and improve the filtration effect. When using, you can choose one or use a combination according to your needs.

In one possible implementation, the upper surface of the first filter 202 is in close contact with the lower surface of the temperature variable membrane 201, the lower surface of the first filter 202 is in close contact with the upper surface of the oxygen pressure membrane 203, and the upper surface of the second filter 204 is in close contact with the lower surface of the oxygen pressure membrane 203. This design can reduce the gaps between the layers of the structure, reduce the occupancy of the internal space of the shell 100, and thereby reduce the blood priming volume.

A blood dispersion structure is disposed on the top of the housing 100 , and the blood inlet nozzle 104 is connected to the blood dispersion structure. The blood dispersion structure is used to disperse the blood entering from the blood inlet nozzle 104 to the upper surface of the temperature variable membrane 201 .

In a possible implementation, the blood dispersion structure includes a buffer space 205 and a plurality of spoilers 206 arranged around the buffer space 205, the buffer space 205 is located in the middle area of the top of the shell 100, the blood inlet nozzle 104 is connected to the buffer space 205, the spoilers 206 extend from the buffer space 205 to the inner wall of the shell 100, and a drainage channel is formed between two adjacent spoilers 206; after the blood enters the buffer space 205 from the blood inlet nozzle 104, it is dispersed to the upper surface of the temperature variable membrane 201 along the drainage channel. In the structures shown in Figures 4 and 5, a plurality of spoilers 206 are evenly spaced around the buffer space 205. Of course, in other embodiments, the spacing between the spoilers 206 may also be unequal.

In a possible implementation, the cross section of the buffer space 205 is circular, the blood inlet nozzle 104 is tangent to the buffer space 205, and the blood enters the buffer space 205 tangentially to form a spiral vortex in the buffer space 205. The blood enters the buffer space 205 tangentially, which can slow down the drop in blood flow rate, and is conducive to the blood flowing to the edge of the buffer space 205, and then quickly dispersed to the upper surface of the temperature variable membrane 201 through the drainage channel constructed by the spoiler 206.

In a possible implementation, the blood inlet nozzle 104 is tilted at the top of the shell 100. Specifically, the blood inlet nozzle 104 is tilted from the top of the shell 100 along the height direction of the oxygenator toward the side away from the shell 100. In this way, when the blood flows from the blood inlet nozzle 104 to the buffer space 205, it will naturally dive downward under the action of gravity, which is more conducive to forming a spiral vortex in the buffer space 205, so that the blood is quickly dispersed to the upper surface of the temperature variable membrane 201.

The exhaust port 110 is arranged at the top of the housing 100, and the exhaust port 110 is connected to the buffer space 205. The exhaust port 110 is higher than the highest position of the buffer space 205 to ensure that the blood in the buffer space 205 will not overflow from the exhaust port 110. During the blood injection process, the blood with a larger mass flows from top to bottom, squeezes the air in the housing 100 to the upper part of the housing 100, and then is discharged from the exhaust port 110. The bubbles intercepted by the first filter 202 and the second filter 204 also move from bottom to top, then merge into the buffer space 205, and are discharged from the exhaust port 110. In the oxygenator of this embodiment, the bleeding port 105 is arranged at the bottom of the oxygenator, and the exhaust port 110 is arranged at the top of the oxygenator. The blood flow direction is opposite to the bubble flow direction, which can reduce the blood pressure loss. The lighter bubbles float up, which is conducive to separating the bubbles in the blood, and the bubble removal effect is good.

In the structures shown in Figures 3 and 4, the buffer space 205 is formed by the top of the housing 100 being arched upward, and the exhaust port 110 is connected to the middle area of the buffer space 205. Of course, the exhaust port 110 can also be arranged away from the middle area of the buffer space 205.

Please refer to Figures 3 and 6. The oxygenator further includes a blocking layer 300, a transverse isolation layer 301, and a longitudinal isolation layer 302. The blocking layer 300 is disposed between the inner wall of the housing 100 and the oxygenation temperature-variable module 200. There is a circulation space between the inner wall of the housing 100 and the blocking layer 300. The transverse isolation layer 301 and the longitudinal isolation layer 302 are disposed in the circulation space. In addition, the transverse isolation layer 301 divides the circulation space into a waterway space and an airway space. The longitudinal isolation layer 302 divides the waterway space into a first waterway space 111 and a second waterway space 112, and divides the airway space into a first airway space 113 and a second airway space 114. The water inlet 106 is connected to the first waterway space 111, the water outlet 107 is connected to the second waterway space 112, the air inlet 108 is connected to the first airway space 113, and the air outlet 109 is connected to the second airway space 114. The inlet of the temperature variable membrane 201 passes through the blocking layer 300 to communicate with the first water path space 111, and the outlet passes through the blocking layer 300 to communicate with the second water path space 112; the inlet of the oxygen pressure membrane 203 passes through the blocking layer 300 to communicate with the first air path space 113, and the outlet passes through the blocking layer 300 to communicate with the second air path space 114.

The temperature-variable membrane 201 includes temperature-variable layers stacked from top to bottom, each temperature-variable layer includes a plurality of temperature-variable membrane 201 filaments arranged side by side, and the temperature-variable membrane 201 filaments in two adjacent temperature-variable layers are interlaced to form a first flow hole that passes through the temperature-variable membrane 201 in the longitudinal direction. The oxygen pressure membrane 203 includes oxygen pressure layers stacked from top to bottom, each oxygen pressure layer includes a plurality of oxygen pressure membrane 203 filaments arranged side by side, and the oxygen pressure membrane 203 filaments in two adjacent oxygen pressure layers are interlaced to form a second flow hole that passes through the oxygen pressure membrane 203 in the longitudinal direction. After the blood is injected into the oxygenator, it is first uniformly dispersed on the upper surface of the temperature-variable membrane 201 under the guidance of the blood dispersion structure, and then passes through the temperature-variable membrane 201, the first filter 202, the oxygen pressure membrane 203 and the second filter 204 in sequence, and flows out from the bleeding port 105 at the bottom, as shown in FIG7 .

When the blood passes through the variable temperature membrane 201, it exchanges heat with the wires of the variable temperature membrane 201 to increase the blood temperature. Among them, the flow direction of the blood when passing through the variable temperature membrane 201 includes flowing downward along the first flow channel and flowing horizontally along the wires of the variable temperature membrane 201; when the blood flows longitudinally along the first flow channel, the blood is subject to small resistance, flows fast, and is less damaged; when the blood flows horizontally along the wires of the variable temperature membrane 201, the contact time between the blood and the wires of the variable temperature membrane 201 is long, and the heat exchange effect is good. Similar to when passing through the variable temperature membrane 201, the flow direction of the blood when passing through the oxygen pressure membrane 203 also includes flowing downward along the second flow channel and flowing horizontally along the wires of the oxygen pressure membrane 203. When flowing downward along the second flow channel, the blood flow rate is faster and the blood is less destructive. When flowing horizontally along the wires of the oxygen pressure membrane 203, the blood is in contact with the wires of the oxygen pressure membrane 203 for a long time, and the oxygenation effect is good. It is worth noting that, since the stacked and staggered structural design of the variable temperature membrane 201 and the oxygen pressure membrane 203 can achieve better heat exchange and oxygenation effects, there is no need to increase the thickness of the oxygen pressure membrane 203 and the variable temperature membrane 201 to improve the heat exchange and oxygenation performance, which can reduce the space occupied by the variable temperature membrane 201 and the oxygen pressure membrane 203, thereby reducing blood pre-filling.

In a possible implementation, the aperture of the first filter 202 is 70 μm to 100 μm, and is used to intercept particles and bubbles with larger diameters in the blood. The aperture of the second filter 204 is not greater than 40 μm, for example, it can be 38 μm, and the second filter 204 is used to intercept particles and bubbles with smaller diameters in the blood. In this embodiment, by setting the first filter 202 and the second filter 204, two-stage filtration of blood is achieved. When the blood passes through the variable temperature membrane 201 and the oxygen pressure membrane 203, particles and bubbles with larger diameters are first filtered out, and only blood and particles and bubbles with smaller diameters contained therein are allowed to reach the oxygen pressure membrane 203. The reduction of particles and bubbles makes the contact between blood and the oxygen pressure membrane 203 better, which can improve the oxygenation effect; the reduction of particles and bubbles in the blood also reduces the filtration pressure of the second filter 204, which can improve the filtration effect of the second filter 204.

In a possible implementation, please refer to Figures 1 to 3, the shell 100 includes a shell body 101, an upper cover 102 arranged at the top opening of the shell body 101, and a lower cover 103 arranged at the bottom opening of the shell body 101, the blood inlet nozzle 104 and the blood dispersion structure are arranged on the upper cover 102, the bleeding port 105 is arranged on the lower cover 103, the water inlet 106 and the water outlet 107 are arranged on one side of the shell body 101 close to the upper cover 102, the air inlet 108 and the air outlet 109 are arranged on one side of the shell body 101 close to the lower cover 103, and the oxygenation temperature variable module 200 is arranged in the shell body 101.

In a possible implementation, the cross section of the oxygenation temperature-variable module 200 is rectangular, such as a rectangle or a square. The height of the oxygenation temperature-variable module 200 is less than the minimum value of the length and width of the oxygenation temperature-variable module 200. This structural design can reduce the pressure loss of blood in the oxygenation temperature-variable membrane 201 group while ensuring sufficient oxygenation of the blood.

Please refer to Figures 7 to 9. The temperature-variable membrane 201 connects the first water channel space 111 and the second water channel space 112, the water inlet 106 connects the first water channel space 111, and the water outlet 107 connects the second water channel space 112. The heating medium passes through the water inlet 106, the first water channel space 111, the temperature-variable membrane 201, the second water channel space 112 and the water outlet 107 in sequence. When the blood flows through the temperature-variable membrane 201, the blood exchanges heat with the heating medium in the temperature-variable membrane 201 to increase the temperature of the blood. The oxygen pressure membrane 203 connects the first gas path space 113 and the second gas path space 114, the air inlet 108 connects the first gas path space 113, and the air outlet 109 connects the second gas path space 114. Oxygen passes through the air inlet 108, the first gas path space 113, the oxygen pressure membrane 203, the second gas path space 114 and the air outlet 109 in sequence. When blood flows through the oxygen pressure membrane 203, the carbon dioxide in the blood is exchanged with the oxygen carried by the oxygen pressure membrane 203, thereby turning the oxygen-poor blood into oxygen-rich blood, and the carbon dioxide in the oxygen pressure membrane 203 is discharged from the air outlet 109.

This embodiment can achieve a better filtering effect without increasing the pressure drop and blood priming volume. The specific analysis is as follows:

First, the oxygenator includes a second filter 204, an oxygen pressure membrane 203, a first filter 202, and a temperature-variable membrane 201 which are stacked in sequence from bottom to top. The aperture of the second filter 204 is smaller than that of the first filter 202. Blood enters the oxygenator from the blood inlet 104, passes through the temperature-variable membrane 201, the first filter 202, the oxygen pressure membrane 203, and the second filter 204 in sequence from top to bottom, and then flows out from the bleeding port 105. The arrangement of the first filter 202 and the second filter 204 increases the filtering area of the oxygenator, and can achieve a better filtering effect.

Second, since the first filter 202 and the second filter 204 are provided so that the filtration area of the oxygenator is large enough, there is no need to make the first filter 202 and the second filter 204 into a pleated shape that occupies a large space, thereby not increasing the internal space of the oxygenator and not increasing the blood priming volume.

Third, in this structural design, blood flows from top to bottom, and the blood fluidity is good. Even if the first filter 202 and the second filter 204 are added on the basis of the variable temperature membrane 201 and the oxygen pressure membrane 203, the pressure loss will not increase much. In addition, the aperture of the first filter 202 is larger than the aperture of the second filter 204, and the resistance of the first filter 202 is smaller than the resistance of the second filter 204. The blood first passes through the first filter 202 and then passes through the second filter 204, and the blood permeability will not be significantly weakened. In addition, the first filter 202 intercepts larger bubbles and impurities on the side of the variable temperature membrane 201, which can improve the permeability of blood when passing through the oxygen pressure membrane 203 and reduce the filtering pressure of the second filter 204.

Note that the above are only preferred embodiments of the present invention and the technical principles used. Those skilled in the art will understand that the present invention is not limited to the specific embodiments herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments, and may include more other equivalent embodiments without departing from the concept of the present invention, and the scope of the present invention is determined by the scope of the appended claims.

Claims (10)

1. A high-efficiency filtration membrane oxygenator, characterized in that it comprises: A housing (100), wherein the upper portion of the housing (100) is provided with a blood inlet nozzle (104), an air outlet (110), a water inlet (106) and a water outlet (107), and the lower portion of the housing (100) is provided with a blood outlet (105), an air inlet (108) and an air outlet (109); an oxygenation temperature-variable module (200) vertically arranged in the housing (100), comprising a second filter (204), an oxygen pressure membrane (203), a first filter (202) and a temperature-variable membrane (201) stacked in sequence from bottom to top, the temperature-variable membrane (201) connecting the water inlet (106) and the water outlet (107), the oxygen pressure membrane (203) connecting the air inlet (108) and the air outlet (109), and the aperture of the second filter (204) is smaller than the aperture of the first filter (202); The upper surface of the first filter (202) is in close contact with the lower surface of the temperature-variable membrane (201), the lower surface of the first filter (202) is in close contact with the upper surface of the oxygen pressure membrane (203), and the upper surface of the second filter (204) is in close contact with the lower surface of the oxygen pressure membrane (203); Blood enters the housing (100) from the blood inlet (104), passes through the temperature-variable membrane (201), the first filter (202), the oxygen pressure membrane (203) and the second filter (204) in sequence from top to bottom, and then flows out from the bleeding port (105), and the gas in the housing (100) is discharged from bottom to top through the exhaust port (110). 2. The oxygenator according to claim 1, characterized in that The pore size of the first filter screen (202) is 70 μm to 100 μm; the pore size of the second filter screen (204) is not greater than 40 μm. 3. The oxygenator according to claim 1, characterized in that A blood dispersion structure is provided on the top of the housing (100), and the blood inlet nozzle (104) is connected to the blood dispersion structure. The blood dispersion structure is used to disperse the blood entering from the blood inlet nozzle (104) to the upper surface of the temperature variable membrane (201). 4. The oxygenator according to claim 3, characterized in that The blood dispersion structure comprises a buffer space (205) and a plurality of spoilers (206) arranged around the buffer space (205); the buffer space (205) is located in the middle area of the top of the shell (100); the blood inlet nozzle (104) is connected to the buffer space (205); the spoilers (206) extend from the buffer space (205) to the inner wall of the shell (100); and a drainage channel is formed between two adjacent spoilers (206); after the blood enters the buffer space (205) from the blood inlet nozzle (104), the blood is dispersed along the drainage channel to the upper surface of the temperature variable membrane (201). 5. The oxygenator according to claim 4, characterized in that The cross section of the buffer space (205) is circular, the blood inlet nozzle (104) is tangent to the buffer space (205), and the blood enters the buffer space (205) tangentially to form a spiral vortex in the buffer space (205). 6. The oxygenator according to claim 4, characterized in that The exhaust port (110) is disposed at the top of the housing (100), and the exhaust port (110) is connected to the buffer space (205). 7. The oxygenator according to claim 6, characterized in that The exhaust port (110) is higher than the highest position of the buffer space (205). 8. The oxygenator according to claim 4, characterized in that The oxygenator further comprises a blocking layer (300), a transverse isolation layer (301) and a longitudinal isolation layer (302); the blocking layer (300) is arranged between the inner wall of the housing (100) and the oxygenation temperature-variable module (200); a circulation space is provided between the inner wall of the housing (100) and the blocking layer (300); the transverse isolation layer (301) and the longitudinal isolation layer (302) are arranged in the circulation space; and the transverse isolation layer (301) divides the circulation space into a water channel space and a gas channel space; the longitudinal isolation layer (302) divides the water channel space into a first water channel space (111) and a second water channel space (112), and divides the gas channel space into a first gas channel space (113) and a second gas channel space (114); The water inlet (106) is connected to the first water path space (111), the water outlet (107) is connected to the second water path space (112), the air inlet (108) is connected to the first air path space (113), and the air outlet (109) is connected to the second air path space (114); The inlet of the temperature-variable membrane (201) passes through the sealing layer (300) to communicate with the first water path space (111), and the outlet passes through the sealing layer (300) to communicate with the second water path space (112); the inlet of the oxygen pressure membrane (203) passes through the sealing layer (300) to communicate with the first air path space (113), and the outlet passes through the sealing layer (300) to communicate with the second air path space (114). 9. The oxygenator according to claim 4, characterized in that The housing (100) comprises a housing (101), an upper cover (102) arranged at an open top of the housing (101), and a lower cover (103) arranged at an open bottom of the housing (101); the blood inlet (104) and the blood dispersion structure are arranged on the upper cover (102); the blood outlet (105) is arranged on the lower cover (103); the water inlet (106) and the water outlet (107) are arranged on a side of the housing (101) close to the upper cover (102); the air inlet (108) and the air outlet (109) are arranged on a side of the housing (101) close to the lower cover (103); and the oxygenation temperature variable module (200) is arranged in the housing (101). 10. The oxygenator according to claim 4, characterized in that The cross section of the oxygenation temperature-variable module (200) is rectangular, and the height of the oxygenation temperature-variable module (200) is less than the minimum value of the length and width of the oxygenation temperature-variable module (200).