CN118501426B

CN118501426B - Sample analyzer and sample analysis method

Info

Publication number: CN118501426B
Application number: CN202410965188.7A
Authority: CN
Inventors: 吴家利; 邹云平; 王蕾
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2024-07-18
Filing date: 2024-07-18
Publication date: 2024-09-27
Anticipated expiration: 2044-07-18
Also published as: CN118501426A

Abstract

The application discloses a sample analyzer and a sample analysis method, wherein the sample analyzer comprises a sample injection channel for conveying a sample rack loaded with sample containers in a first direction, at least one incubation device and a grabbing device for transporting the sample containers; the incubation device is provided with at least one incubation cavity for accommodating the sample container, and the moving path of the grabbing device is provided with a first grabbing position; when the gripping device is in the first gripping position and the sample container is received in the incubation cavity, the gripping device is spaced apart from the sample container in Wen Yoqiang. The application can automatically deagglomerate the blood sample judged as the agglutinated sample through the incubation treatment of the incubation device, thereby eliminating the need of a user to independently perform manual deagglomeration operation, simplifying the treatment flow of the agglutinated sample, reducing the treatment cost and improving the detection and analysis efficiency of the sample analyzer.

Description

Sample analyzer and sample analysis method

Technical Field

The invention relates to the technical field of blood analysis, in particular to a sample analyzer and a sample analysis method.

Background

A blood sample analyzer is an instrument for detecting parameters such as the number, volume, and proportion of blood cells (e.g., red blood cells, white blood cells, platelets, hemoglobin, etc.) in blood. Along with the progress of technology and the development of science and technology, the function of the blood analyzer is continuously expanded, the performance is continuously improved, the degree of automation is continuously improved, and the blood analyzer is widely applied to blood analysis.

Among them, in the case of blood cell detection, blood cells are generally uniformly distributed in a blood sample, but when lectin content is increased or sample temperature is too low, blood cells uniformly suspended in the sample are aggregated due to charge imbalance, etc., causing hemagglutination. Direct detection of aggregated blood cells can cause the detected parameters to deviate from the actual values, affecting the accuracy of the measurement results of the hematology analyzer.

In the existing blood analyzer, in the process of processing the hemagglutination sample, a user is required to manually identify and process the hemagglutination sample, the process is complicated, the processing reagent is high, the labor cost is high, and the analysis efficiency of the blood analyzer is not beneficial to improvement.

Disclosure of Invention

The invention aims to provide a sample analyzer and a sample analysis method.

The technical scheme adopted by the embodiment of the application for solving the technical problems is as follows:

a sample analyzer is constructed, comprising:

The sample feeding device comprises a sample feeding channel, a sampling device and a sampling device, wherein the sample feeding channel is used for conveying a sample rack loaded with a sample container in a first direction, the sample feeding channel is provided with a grabbing position and a sampling position, and the sampling position and the grabbing position are arranged at intervals in the first direction;

At least one incubation device forming at least one incubation cavity for receiving the sample container, the grasping locations being spaced apart from the Wen Yoqiang in a second direction, the incubation device for incubating a blood sample in the sample container within the Wen Yoqiang that is judged to be an aggregate sample; and

A gripping device for handling the sample container, the gripping device being identical in position to the gripping position and Wen Yoqiang in the first direction, the gripping device being for gripping the sample container from a side of the sample container in the second direction, the gripping device being movably arranged in the second direction and in a third direction;

The moving path of the grabbing device is provided with a first grabbing and placing position, when the grabbing device is located at the first grabbing and placing position, the grabbing device corresponds to the sample container located at the grabbing position on the sample rack, so that the sample container is grabbed from or placed on the sample rack; when the gripping device is in the first gripping position and the sample container is contained within the incubation cavity, the gripping device is spaced apart from the sample container within the Wen Yoqiang;

The first direction, the second direction and the third direction are perpendicular to each other, the first direction is the length direction of the sample injection channel, the second direction is the width direction of the sample injection channel, and the third direction is the height direction of the sample injection channel.

In some embodiments, the incubation cavity is located on the posterior side of the grasping location.

In some embodiments, the gripping device further comprises a second gripping position on the path of movement of the gripping device, the gripping device corresponding to the Wen Yoqiang when the gripping device is in the second gripping position to grip or place the sample container from the Wen Yoqiang to the incubation cavity; the second gripping position is lower than the first gripping position in the third direction.

In some embodiments, the incubation cavity is movably arranged along the third direction, and the moving path of the incubation cavity comprises a avoidance position and a containing position, wherein the containing position is higher than the avoidance position; the moving path of the grabbing device further comprises a second grabbing and placing position;

When the gripping device is in the second gripping position, the incubation cavity is in the receiving position, the gripping device corresponding to the Wen Yoqiang to grip or place the agglutination sample container from or to the Wen Yoqiang; when the gripping device is positioned at the first gripping position and the sample container is accommodated in the incubation cavity, the incubation cavity is positioned at the avoiding position; the second gripping position is located at a position equal to or lower than the first gripping position in the third direction.

In some embodiments, when the gripping device is in the first gripping position, a distance between the gripping device and the Wen Yoqiang bottom end in the third direction is greater than or equal to a height of the sample container.

In some embodiments, the gripping device comprises a gripping portion, a connecting portion, and a guide rail; the guide rail extends along the third direction and the second direction; the connecting part is movably arranged on the guide rail, the grabbing part is connected with the connecting part, and an avoidance space is defined between the grabbing part and the connecting part;

When the grabbing device is located at the first grabbing position, the avoiding space corresponds to Wen Yoqiang, and the distance from the top end of the avoiding space to the bottom end of Wen Yoqiang in the third direction is greater than or equal to the height of the sample container.

In some embodiments, the connection portion has a toppled L-shape in a projection on a plane defined by the second direction and the third direction, including a vertical portion extending in the third direction and a horizontal portion extending in the second direction; the upper end of the vertical part is connected with the front side end of the horizontal part, one end of the grabbing part is connected with the bottom end of the vertical part, and the grabbing part extends to one side far away from the vertical part along the second direction; the grasping portion, the vertical portion, and the horizontal portion together define the avoidance space.

In some embodiments, the distance of the grasping location from the Wen Yoqiang in the second direction is greater than or equal to the length of the grasping portion in the second direction;

When the grabbing device is located at the first grabbing position, the incubation cavity corresponds to the horizontal portion, and the distance from the bottom end of the horizontal portion to the bottom end Wen Yoqiang in the third direction is greater than or equal to the height of the sample container.

In some embodiments, the sample analyzer further comprises at least one mixing device, wherein at least one mixing cavity for accommodating the sample container is formed on the mixing device, and the mixing device is used for carrying out mixing treatment on the blood sample in the sample container in the mixing cavity;

The mixing cavity is the same as the grabbing position and the Wen Yoqiang are positioned in the first direction; the mixing chamber is located between the grabbing position and the incubation chamber in the second direction, or the mixing chamber is located at a side of the incubation chamber away from the grabbing position in the second direction.

In some embodiments, the moving path of the gripping device further comprises a third gripping position, when the gripping device is located in the third gripping position, the gripping device corresponds to the mixing cavity to grip or place the sample container from or to the mixing cavity; the third gripping position is located at a position equal to or lower than the first gripping position in the third direction.

In some embodiments, the gripping device further comprises a second gripping position on the path of movement of the gripping device, the gripping device corresponding to the Wen Yoqiang when the gripping device is in the second gripping position to grip or place the sample container from the Wen Yoqiang to the incubation cavity;

the mixing chamber is located between the grasping location and the incubation chamber in the second direction; the second grabbing and placing position is lower than the third grabbing and placing position in the third direction;

Or, the mixing chamber is located at one side of the incubation chamber away from the grabbing position in the second direction; the third grabbing and placing position is equal to or lower than the second grabbing and placing position in the third direction, and the second grabbing and placing position is lower than the first grabbing and placing position in the third direction.

In some embodiments, the incubation cavity is movably arranged along the third direction, and the moving path of the incubation cavity comprises a avoidance position and a containing position, wherein the containing position is higher than the avoidance position;

The mixing chamber is located between the grasping location and the incubation chamber in the second direction; the third gripping position is equal to or lower than the first gripping position in the third direction, and the second gripping position is equal to or lower than the third gripping position in the third direction; when the grabbing device is at the third grabbing position and the sample container is contained in the incubation cavity, the incubation cavity is located at the avoiding position;

Or, the mixing chamber is positioned at one side of the incubation chamber away from the grabbing position in the second direction; the second gripping position is equal to or lower than the first gripping position in the third direction, and the third gripping position is equal to or lower than the second gripping position in the third direction; when the gripping device is in the first gripping position and the sample container is accommodated in the incubation cavity, the incubation cavity is located in the avoidance position.

In some embodiments, the homogenization chamber is located on a side of the incubation chamber remote from the grasping location in the second direction; the moving path of the grabbing device further comprises a first transferring position, a second transferring position and a third transferring position, and the positions of the first transferring position, the second transferring position and the third transferring position in the third direction are the same; the first transfer position is positioned above the first grabbing and placing position; the second translocation site is located above the incubation cavity; the third transfer position is positioned above the mixing cavity;

the grabbing device comprises grabbing parts, and the grabbing parts are arranged in a swinging mode along the first direction;

the sample analyzer further comprises a control device which is respectively in control connection with the incubation device, the mixing device and the grabbing device; the control device is configured to control the gripping part to swing and avoid when passing through the second transfer position when the gripping device moves from the first transfer position to the third transfer position or from the third transfer position to the first transfer position.

In some embodiments, the mixing device is a trace blood mixing device, and is used for mixing trace blood samples;

The sample analyzer further comprises a control device, wherein the control device is in control connection with the sample feeding channel, the grabbing device and the mixing device, and the control device is configured to control the sample feeding channel to convey the sample rack and control the grabbing device to grab the sample container to be carried to the mixing cavity when the blood sample contained in the sample container at the grabbing position on the sample rack is the trace blood sample.

In some embodiments, the grasping device is further configured to uniformly mix the constant blood sample.

In some embodiments, the sample analyzer further comprises a manual sample introduction device provided with a sample introduction cavity for placing a sample container, wherein the sample introduction cavity and the sampling position are arranged at intervals in the second direction.

In some embodiments, at least one incubation device is disposed on the manual sample introduction device, and the Wen Yoqiang of the incubation device is spaced apart from the sample introduction chamber and the sampling site in the second direction.

In some embodiments, at least one incubation device is disposed on the manual sample introduction device, and the Wen Yoqiang of the incubation device is the sample introduction chamber on the manual sample introduction device.

In some embodiments, the sample analyzer further comprises a control device in control connection with the sample introduction channel, the incubation device, and the grasping device, respectively; the control device is configured to control the sample introduction channel to convey the sample rack and control the gripping device to grip the agglutination sample container for conveying to the incubation cavity in response to the sample container on the sample rack being the agglutination sample container.

A sample analysis method applied to the sample analyzer of any one of the above, the sample analyzer further comprising a control device in control connection with the sample introduction channel, the incubation device and the gripping device, respectively, the sample analysis method comprising the steps of:

S1, a control device acquires information of a blood sample in a sample container loaded on a sample rack on a sample injection channel, and judges the type of the blood sample according to the information;

step S2, when judging that the blood sample is an agglutination sample, controlling the sample feeding channel to convey the sample rack so that a sample container containing the agglutination sample on the sample rack is positioned at a grabbing position;

and S3, controlling a grabbing device to transport the sample container containing the agglutination sample from the grabbing position to an incubation cavity, and controlling the incubation device to incubate the agglutination sample.

In some embodiments, the gripping device further comprises a second gripping location on the path of movement of the gripping device, the gripping device corresponding to the Wen Yoqiang when the gripping device is in the second gripping location, to grip or place the agglutinating sample container from the Wen Yoqiang to the incubation cavity;

The step S3 includes:

Step S31, controlling the grabbing device to move to the first grabbing position and grabbing the sample container containing the agglutination sample;

step S32, controlling the gripping device to move from the first gripping position to the second gripping position, and controlling the gripping device to place the sample container containing the agglutination sample in the Wen Yoqiang;

step S33, controlling the incubation device to perform incubation treatment on the agglutination sample in the sample container of the incubation cavity.

In some embodiments, the sample analyzer further comprises at least one mixing device having at least one mixing chamber formed thereon for receiving the sample container; the mixing cavity is the same as the grabbing position and the Wen Yoqiang are positioned in the first direction; the control device is in control connection with the mixing device;

The step S33 includes: controlling the incubation device to perform incubation treatment for a preset time on the agglutination sample in the sample container of the incubation cavity;

After the step S33, the step S3 further includes:

and step S34, controlling the grabbing device or the mixing device to mix the sample containers which are judged to be non-agglutinated samples on the sample rack within the preset time.

In some embodiments, the step S34 includes:

Step S341, controlling the sample feeding channel to transmit the sample rack within the preset time, so that the sample container with the non-agglutination sample accommodated on the sample rack is transmitted to the grabbing position;

Step S3421, when judging that the non-agglutination sample is a constant blood sample, controlling the grabbing device to grab the sample container containing the constant blood sample, and uniformly mixing the constant blood sample;

And step S3422, when the non-agglutination sample is judged to be a trace blood sample, controlling the grabbing device to transport the sample container containing the trace blood sample to the mixing cavity, and controlling the mixing device to mix the trace blood sample.

In some embodiments, the incubation cavity is movably arranged along the third direction, and the moving path of the incubation cavity comprises a avoidance position and a containing position, wherein the containing position is higher than the avoidance position; the moving path of the grabbing device further comprises a third grabbing position, and the third grabbing position corresponds to the mixing cavity;

The step S32 includes: controlling the incubation device such that the incubation cavity moves to the receiving location and the gripping device moves from the first gripping location to the second gripping location, the gripping device being controlled to place the sample container containing the agglutination sample within the Wen Yoqiang;

The step S3421 includes: when the non-agglutination sample at the grabbing position is judged to be a constant blood sample, controlling the incubation device to enable the incubation cavity to move to the avoiding position, controlling the grabbing device to move to the first grabbing and placing position, grabbing the sample container containing the constant blood sample, and uniformly mixing the constant blood sample;

the step S3422 includes: when the non-agglutination sample located at the grabbing position is judged to be a trace blood sample, the incubation device is controlled to enable the incubation cavity to move to the avoiding position, the grabbing device is controlled to move to the first grabbing and placing position, the sample container containing the trace blood sample is grabbed, the grabbing device is controlled to move from the first grabbing and placing position to the third grabbing and placing position, the sample container containing the trace blood sample is placed in the mixing cavity, and the mixing device is controlled to uniformly mix the trace blood sample.

In some embodiments, the homogenization chamber is located on a side of the incubation chamber remote from the grasping location in the second direction;

the step S3421 includes: when the non-agglutination sample at the grabbing position is judged to be a constant blood sample, controlling the incubation device to enable the incubation cavity to move to the avoiding position, controlling the grabbing device to move to the first grabbing and placing position, grabbing the sample container containing the constant blood sample, and uniformly mixing the constant blood sample.

In some embodiments, the moving path of the gripping device further includes a first transferring position, a second transferring position, a third transferring position and a third gripping and placing position, where the positions of the first transferring position, the second transferring position and the third transferring position in the third direction are the same; the first transfer position is located above the first grabbing and placing position, the second transfer position is located above the second grabbing and placing position, and the third transfer position is located above the third grabbing and placing position; the third grabbing and placing position corresponds to the mixing cavity; the mixing cavity is positioned at one side of the incubation cavity away from the grabbing position in the second direction; the grabbing device comprises grabbing parts, and the grabbing parts are arranged in a swinging mode along the first direction;

The step S3422 further includes:

When the non-agglutination sample at the grabbing position is judged to be a trace blood sample, controlling the grabbing device to move to the first grabbing position to grab the sample container containing the trace blood sample;

Controlling the grabbing device to move from the first grabbing position to the third grabbing position; placing the sample container containing the trace blood sample in the mixing cavity; and controlling the mixing device to uniformly mix the trace blood sample;

Wherein when the gripping device is between the first transfer position and the second transfer position, the gripping device is controlled so that the gripping part deflects along the first direction, so that the sample container containing the trace blood sample avoids the sample container containing the agglutination sample in the Wen Yoqiang; and when the grabbing device is positioned between the second transferring position and the third transferring position, controlling the grabbing device so that the grabbing part swings back.

The embodiment of the invention has at least the following beneficial effects:

By arranging the incubation device, the sample analyzer constructed by the application not only can detect the blood sample, but also can automatically deagglomerate the blood sample judged to be the agglutinated sample through the incubation treatment of the incubation device, thereby avoiding the need of a user to independently perform manual deagglomeration operation, simplifying the treatment flow of the agglutinated sample, reducing the treatment cost and improving the detection analysis efficiency of the sample analyzer.

Drawings

The application will be further described with reference to the accompanying drawings and examples, in which:

FIG. 1 is a top view showing a part of the structure of a sample analyzer according to a first embodiment of the present application;

FIG. 2 is a block diagram of the sample analyzer shown in FIG. 1;

FIG. 3 is a side view of a portion of the structure of the sample analyzer shown in FIG. 1 in an embodiment in which the mixing chamber is located on a side of the incubation chamber remote from the sampling site;

FIG. 4 is a side view of a portion of the sample analyzer shown in FIG. 1 with the grasping device in a third grasping position and the sample container in the incubation cavity in a particular embodiment of the mixing chamber between the incubation cavity and the sampling position;

FIG. 5 is a side view of a portion of the structure of a sample analyzer of a second embodiment of the present application in which the mixing chamber is located on a side of the incubation chamber remote from the sampling site;

FIG. 6 is a side view of a portion of the structure of the sample analyzer of the second embodiment of the present application with the incubation cavity in the side of the incubation cavity away from the sampling position in a specific embodiment of the incubation cavity;

FIG. 7 is a side view of a portion of the structure of a sample analyzer of a second embodiment of the application in which the mixing chamber is located between the incubation chamber and the sampling position;

FIG. 8 is a side view of a portion of the structure of a sample analyzer of a second embodiment of the application with a mixing chamber between an incubation chamber and a sampling site, the incubation chamber being in a yielding position;

FIG. 9 is a side view of a portion of the structure of a sample analyzer in a third embodiment of the application in which the mixing chamber is located on the side of the incubation chamber remote from the sampling site;

FIG. 10 is a side view of a portion of the structure of a sample analyzer in a third embodiment of the application in which the mixing chamber is located between the incubation chamber and the sampling station;

FIG. 11 is a flow chart of a sample analysis method in an embodiment of the application;

FIG. 12 is a flow chart of S3 of FIG. 11 in one embodiment;

FIG. 13 is a flow chart of S3 of FIG. 11 in another embodiment;

FIG. 14 is a flow chart of S34 of FIG. 13 in one embodiment;

FIG. 15 is a flow chart of S3 in FIG. 11 in yet another embodiment;

Fig. 16 is a flowchart of S3422 in fig. 14 in an embodiment.

Detailed Description

For a clearer understanding of technical features, objects and effects of the present application, a detailed description of embodiments of the present application will be made with reference to the accompanying drawings. In the following description, it should be understood that the directions or positional relationships indicated by "front", "rear", "upper", "lower", "left", "right", "longitudinal", "transverse", "vertical", "horizontal", "top", "bottom", "inner", "outer", "head", "tail", etc. are configured and operated in specific directions based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present application, and do not indicate that the apparatus or element to be referred to must have specific directions, and thus should not be construed as limiting the present application.

It should also be noted that unless explicitly stated or limited otherwise, terms such as "mounted," "connected," "secured," "disposed," and the like are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. When an element is referred to as being "on" or "under" another element, it can be "directly" or "indirectly" on the other element or one or more intervening elements may also be present. The terms "first," "second," "third," and the like are used merely for convenience in describing the present application and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, whereby features defining "first," "second," "third," etc. may explicitly or implicitly include one or more such features. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art according to the specific circumstances.

In the following description, for purposes of explanation and not limitation, specific details are set forth such as the particular system architecture, techniques, etc., in order to provide a thorough understanding of the embodiments of the present application. It will be apparent, however, to one skilled in the art that the present application may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.

Fig. 1 to 4 show a sample analyzer 1 in a first embodiment of the present application, which sample analyzer 1 can perform detection analysis on a blood sample and can also perform incubation treatment on a blood sample determined to be an agglutination sample.

The sample analyzer 1 comprises a sample introduction channel 10, a gripping device 40 and at least one incubation device 20. Wherein the sample introduction channel 10 is arranged extending in a first direction for transporting the sample rack 2 loaded with the sample containers 201 in the first direction. The incubation device 20 can perform an incubation process on the blood sample judged as an agglutinated sample in the sample container 201 to achieve an effect of deagglomeration and improve detection accuracy. The gripping device 40 is used for handling the sample container 201.

It should be understood that the sample rack 2 has a plurality of receiving cavities, and the plurality of sample containers 201 are placed in the plurality of receiving cavities one by one. The sample container 201 is for holding a blood sample. When the blood sample in the sample container 201 on the sample rack 2 needs to be detected, the sample rack 2 is only required to be placed on the sample introduction channel 10, and the collection and detection of the blood sample in each sample container 201 on the sample rack 2 can be realized through the transmission of the sample introduction channel 10 and the cooperation between the rest device modules of the sample analyzer 1.

Specifically, as shown in fig. 1, the sample channel 10 has a grabbing bit 11 and a sampling bit 12, where the grabbing bit 11 and the sampling bit 12 are spaced apart in a first direction. When a certain sample container 201 on the sample rack 2 is transferred to the gripping position 11 of the sample channel 10 along with the movement of the sample rack 2, the gripping device 40 may take the sample container 201 out of the sample rack 2 or replace the sample container 201 after the processing is completed with the sample rack 2. When a certain sample container 201 on the sample rack 2 is transferred to the sampling site 12 of the sample channel 10 along with the movement of the sample rack 2, the sample analyzer 1 can collect a blood sample from the inside of the sample container 201.

The incubation device has at least one incubation cavity 21 formed therein for receiving a sample container 201. The incubation cavity 21 is spaced apart from the grasping location 11 in the second direction.

In this embodiment, the incubation cavity 21 is used for placing a sample container 201 containing an agglutinating sample therein. It is to be understood that the incubation device 20 is not limited to the case where the incubation cavity 21 can only hold the sample container 201 containing the agglutinating sample, i.e. the incubation device 20 can also perform incubation treatment on non-agglutinating samples.

It is to be understood that the relationship between the reference to "blood sample" and "aggregate sample" is: blood samples can be classified into agglutination samples and non-agglutination samples according to whether cells are agglutinated or not. For agglutination samples, including but not limited to, erythrocyte agglutination samples, leukocyte agglutination samples, and PLT (platelet) agglutination samples.

When blood cells are aggregated due to factors such as low temperature, lectin abnormality and the like, the volume change of the blood cells is abnormal, so that when the sample analyzer 1 detects a blood sample, the red blood cell count is artificially changed, and the detection accuracy of the sample analyzer 1 is affected. Therefore, when it is detected that the blood sample is an agglutination sample, it is necessary to perform a deagglomeration operation such as an incubation treatment on the agglutination sample and perform a secondary detection on the deagglomerated sample to ensure the accuracy of the blood sample detection.

The determination of the agglutination sample may be performed by the detection result of the blood sample. For example, when the agglutination sample is a red blood cell agglutination sample, the detection result may include at least one of a red blood cell mean hemoglobin concentration (MCHC), a red blood cell mean volume (MCV), a red blood cell packed volume (HCT), a red blood cell count (RBC), and a mean red blood cell hemoglobin content (MCH). The sample analyzer 1 determines whether or not the blood sample is coagulated based on the parameters of the detection result. For example, when the detection result includes the MCHC parameter, whether the blood sample is agglutinated may be determined by determining whether the MCHC is greater than a preset value, for example, the preset value may be 360g/L or 380g/L, and when the MCHC is greater than 360g/L or 380g/L, the blood sample may be determined to be an agglutinated sample. When the detection result includes the MCV parameter, it is possible to determine whether the blood sample is coagulated by determining whether the MCV is high. When the detection result includes HCT parameters, it is possible to determine whether the blood sample is coagulated by determining whether HCT is low. When the test results include RBC parameters, it can be determined whether the blood sample is agglutinated by determining whether the RBC is low. When the detection result includes the MCH parameter, whether the blood sample is agglutinated may be determined by determining whether the MCH is high, for example, whether the MCH is greater than a predetermined value, the predetermined value may be 33pg, and if the MCH is greater than 33pg, the blood sample may be determined to be an agglutinated sample. When the test result includes HGB and RBC parameters, it is determined whether the condition of the agglutination sample is whether the ratio of HGB to RBC is greater than a preset value, for example, the preset value may be 30. It will be appreciated that any combination of the above methods of determination may be used, for example, whether the blood sample is agglutinated may be determined according to the ratio of HGB to RBC, MCH, MCHC, or whether the blood sample is agglutinated may be determined according to other parameters. The determination method for determining whether the blood sample is coagulated belongs to the prior art, and is not specifically limited and described in detail herein.

Reference to an "incubation treatment" may refer to heating the agglutinated sample for a preset time with a preset incubation. Specifically, the "preset temperature" is preferably a temperature in the range of 35 ℃ to 43 ℃. For example, the preset temperature may be set to 35 ℃, 36 ℃, 37 ℃, 38 ℃, 39 ℃,40 ℃, 41 ℃, 42 ℃, or 43 ℃ to be close to the temperature in the human body, thereby realizing that the aggregated blood cells in the aggregated sample can be deagglomerated at the preset temperature. The "preset time" is preferably 5 minutes to 60 minutes. For example, the preset time may be 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, 60 minutes, etc.

It is to be understood that the longer the preset time, the better the deagglomeration effect, but the lower the efficiency of sample analysis, so the time of incubation treatment can be flexibly controlled according to the extent of agglutination of the agglutinated sample, sample analysis schedule, etc. The present invention is not particularly limited herein.

The gripping means 40 is movably arranged in the second direction and in the third direction, the gripping means 40 grips the sample container from its side in the second direction and is positioned in the same way as the gripping station 11 and the incubation cavity 21 in the first direction, so that the gripping means 40 can transport the sample container 201 between the gripping station 11 and the incubation cavity 21.

Referring to fig. 3, the gripping device 40 has a first gripping position 401 along a moving path. When the gripping means 40 is in the first gripping position 401, it corresponds to the sample container 201 on the sample rack 2 in the gripping position 11. The gripping device 40 can then grip the sample container 201 from the sample rack 2 or replace the sample container 201 after the end of the treatment with the sample rack 2. When the gripping device 40 is located at the first gripping position 401 and the sample container 201 is accommodated in the incubation cavity 21, the positional relationship between the first gripping position 401 and the incubation cavity 21 may be such that the gripping device 40 located at the first gripping position 401 is spaced apart from the sample container 201 in the incubation cavity 21 to avoid.

It is to be understood that "when the gripping means 40 is in the first gripping position 401 it corresponds to the sample container 201 on the sample rack 2 in the gripping position 11" means that the gripping means 40 in the first gripping position 401 can grip the sample container 201 in the first gripping position 401. Taking an example that the sample container 201 located at the gripping position 11 on the sample rack 2 is not taken out, the gripping operation may be performed by the portion of the gripping device 40 for gripping the sample container 201 when the gripping device 40 is located at the first gripping position 401 at this time.

Specifically, the first pick-and-place position 401 may not be limited to a specific point. At the first gripping position 401, the gripping device 40 may perform gripping and placing operations on the sample container 201 by slightly moving horizontally (e.g., sampling the sample container 201 by horizontally moving a fork), or by an action of the gripping device 40 itself (e.g., gripping device 40 with a jaw, which is tightened by opening the jaw), or the like. However, it should be understood that, in the present embodiment, when the gripping device 40 is located at the same position as the gripping position 11 in both the first direction and the second direction, the bottom end position of the moving path of the gripping device 40 in the third direction is the first gripping position 401.

It is understood that the first direction, the second direction, and the third direction are perpendicular to each other. The "first direction" may refer to the length direction (extending direction) of the sample introduction channel 10, and in this embodiment refers to the X-axis direction in fig. 1. The "second direction" may refer to the width direction of the sample injection channel 10, and in this embodiment refers to the Y-axis direction in fig. 1 and 3. The "third direction" may refer to the height direction of the sample introduction channel 10, and in this embodiment refers to the Z-axis direction in fig. 3.

The present application provides the incubation device 20, so that the sample analyzer 1 constructed according to the present application can detect not only blood samples, but also blood samples judged to be agglutinated samples, and the agglutinated samples can be deagglomerated by incubation treatment of the incubation device 2, thereby eliminating the need for a user to perform manual deagglomeration operation alone, simplifying the treatment flow of the agglutinated samples, reducing the treatment cost, and improving the detection analysis efficiency of the sample analyzer 1.

In some embodiments, the incubation device 20 further comprises a heating assembly (not shown) for performing an incubation treatment on the blood sample within the incubation cavity 21.

In this embodiment, the number of incubators 20 and incubators 21 is one, i.e., one incubators 20 has one incubator 21. In other alternative embodiments, the number of incubation devices 20 may be set to two, three, etc. The incubation device 20 may also have one, two, three, etc. incubation chambers 21. When one incubation device 20 is provided with a plurality of incubation cavities 21, the heating assembly of the incubation device 20 may simultaneously or separately perform an incubation treatment for the plurality of incubation cavities 21.

Since the incubation time is long, by providing a plurality of incubation chambers 21, the sample analyzer 1 can simultaneously perform the incubation of a plurality of blood samples judged to be coagulated samples. Avoiding the occurrence of multiple agglutination samples requiring in-line processing.

Specifically, the heating means may be a solid heat generating member such as a heating resistor, and the sample container 201 of the agglutination sample is directly heated by heating the solid in a solid heat conduction manner, thereby performing incubation treatment of the agglutination sample. It can also be incubated by water bath heating, air bath heating, etc. The present invention is not particularly limited herein.

As shown in fig. 2, in some embodiments, the sample analyzer 1 further comprises a detection device 50, and the detection device 50 is configured to collect a blood sample in the sample container 201 and perform analysis and detection on the blood sample. The detection device 50 comprises a sampling needle (not shown) arranged movably in a third direction for taking a blood sample in a sample container 201 located on the sampling site 12.

In some embodiments, the testing device 50 may further include a dilution assembly (not shown) by which a multiple of the blood sample is diluted prior to testing, as well as to provide deagglomeration. It may be used alone to dilute the coagulated sample or may be used in combination with the incubator 20 and/or the mixer 30 to perform multiple deagglomeration treatments on the coagulated sample.

Specifically, the diluting component may be located on a sample-spitting path of the sampling needle, and after the blood sample is collected by the sampling needle, the blood sample is released to the diluting component by the sampling needle to be diluted by a certain multiple, and then enters a detection place of the detection device 50 for detection by the diluting component.

Wherein a "certain multiple" may preferably be in the range of 60 to 1024 times, which may be, for example, 60, 120, 250, 500 or 1000. For another example, the multiple may be 64, 128, 256, 512, 1024, or the like. It is to be understood that the multiple may be flexibly selected according to the extent of agglutination of the agglutination sample, and is not particularly limited herein; in some embodiments, the diluent used to dilute the blood sample may be a heated hot diluent to thermally dilute the blood sample, with the hot dilution providing better deagglomeration of the agglutinated sample.

With continued reference to fig. 2, the sample analyzer 1 further includes a control device 60, where the control device 60 is electrically connected to the sample feeding channel 10, the incubation device 20, the gripping device 40, and the detection device 50, respectively, and is used for controlling the operation of each device, so that the sample analyzer 1 can implement a blood sample collection and detection function, an incubation processing function, and the like.

For the sample analyzer 1 constructed in this embodiment, the control device 60 controls the other devices to cooperate during a specific detection process to sequentially collect and detect the blood sample in each sample container 201 on the sample rack 2. The control device 60 may determine whether the blood sample in the sample container 201 is an aggregated sample based on the generated detection result. When it is determined that the blood sample in one of the sample containers 201 is an agglutination sample, the control device 60 controls the transfer of the sample container 201 containing the agglutination sample to the incubation device 20 for incubation so as to achieve deagglomeration of the agglutination sample. After the deagglomeration is completed, the control device 60 further controls the sample container 201 containing the agglutinated sample to be transferred to the sampling position 11, and the agglutinated sample after the incubation treatment is completed is subjected to secondary sampling detection, and the detection result is generated again to determine until it is determined that the sample is not agglutinated, and the detection result generated at this time can be regarded as the detection result of the blood sample.

Specifically, since a certain period of time is required from the collection of the blood sample to the detection of the result (not limited herein), the period of time may be longer than or shorter than the interval time between sampling by the sampling needle in the adjacent two sample containers 201 during the sequential collection of the blood samples on the sample rack 2. Therefore, when the sample analyzer 1 detects an agglutination sample, the control device 60 can be arranged in a targeted manner according to the selection of no user.

For example, the control device 60 may be configured to: the sample rack 2 sequentially conveys the sample containers 201 to the sampling position 12 through the sample introduction channel 10 for sampling, and each sample container 201 can wait at the sampling position 12 after the sampling of the sample position 12 is finished until the control device 60 obtains the judgment of the detection result of the blood sample in the sample container 201. If the sample is not agglutinated, the sample introduction channel 10 is controlled to continuously convey the sample rack 2, and the next adjacent sample container 201 to be sampled is conveyed to the sampling position 12 for sampling. In the case of an agglutination sample, the sample introduction path 10 is controlled to convey the sample rack 2, and the sample container 201 containing the agglutination sample is conveyed to the gripping position 11, and gripped by the gripping device 40 to the incubation cavity 21 for incubation.

For example, the control device 60 may be further configured to: the sample rack 2 sequentially conveys the sample containers 201 to the sampling position 12 for sampling through the sample channel 10, and after the sample containers 201 are sampled from the sampling position 12, the sample channel 10 is continuously controlled to convey the sample rack 2, so that the sample containers 201 to be sampled adjacent to the sample containers 201 after the sampling is finished are sampled, and so on. In this process, the control device 60 generates detection information one by one for the blood sample sampled one by one. Since the detection process is performed one by one, when it is determined that the blood sample in one of the sample containers 201 is an aggregated sample, the control device 60 may suspend the sampling and detection of the blood sample, and determine the position of the sample container 201 containing the aggregated sample on the sample rack 2 according to the detection order of the aggregated sample, or according to the coding information on the sample container 201, or the like. At this time, the control device 60 may control the sample introduction path 10, transfer the sample rack 2 to transfer the sample container 201 containing the agglutination sample from the sampling site 12 to the grasping site 11, and transfer to the incubation device 20 for incubation treatment by the grasping device 40.

For example, the control device 60 may be further configured to: the sample rack 2 sequentially conveys the sample containers 201 to the sampling position 12 for sampling through the sample channel 10, and after the sample containers 201 are sampled from the sampling position 12, the sample channel 10 is continuously controlled to convey the sample rack 2, so that the sample containers 201 to be sampled adjacent to the sample containers 201 after the sampling is finished are sampled. And so on until all sample containers 201 on the sample rack 2 have been sampled. The post-control device 60 determines the position of the sample container 201 containing the agglutination sample on the sample rack 2 based on the detection order of the agglutination sample based on the determination result generated one by one (assuming that there is one agglutination sample on the sample rack 2), or based on the coding information on the sample container 201, or the like. At this time, the control device 60 may control the sample introduction path 10, transfer the sample rack 2 to transfer the sample container 201 containing the agglutination sample from the sampling site 12 to the grasping site 11, and transfer to the incubation device 20 for incubation treatment by the grasping device 40.

It should be understood that the arrangement of the control device 60 is more selective with respect to the transfer process and the secondary detection process after the blood sample is determined to be an aggregated sample, and the above are merely examples of several possibilities, and are not limited thereto. It should be understood that the arrangement of the control device 60 is sufficient that the blood sample can be automatically returned to the sample analyzer 1 for deagglomeration such as incubation after it is determined that the blood sample is an agglutinated sample, and the detection can be performed again under the control of the control device 60.

It should be understood that, for the "code" on the sample container 201, the status view of the blood sample in the sample container 201 may be a two-dimensional code, a bar code, an identification code, or any expression form that may refer to information of a specific sample container 201, so that the sample container 201 and the blood sample accommodated therein may be in one-to-one correspondence. The present invention is not particularly limited herein. The control device 60 can be used for reading and recording each sample container 201 when the sample container 201 enters the sample analyzer 1 through the sample introduction channel 10 along with the sample rack 2, so that the control device 60 can obtain various original information such as the shape, the size, the source information of the sample, the blood sample amount information and the like of the sample container 201 according to the encoded information, and then perform targeted detection processing on the blood sample in the sample container 201.

In some embodiments, the sample channel 10 may further be provided with an identification device (not shown in the figure) for identifying the code on the sample container 201, so as to achieve one-to-one correspondence between the blood sample in the sample container 201 and the detection result.

It should be understood that the identification device may be a conventional image acquisition processing device, and the like, and is not particularly limited herein, so long as the identification of the sample container 201 can be achieved by the foregoing coding of the sample container 201.

In some embodiments, the sample analyzer 1 further includes a rack (not shown in the drawings), in which the incubation device 20, the grabbing device 40, the detecting device 50, etc. are disposed to perform the function of housing protection, and may further improve the overall aesthetic appearance of the sample analyzer 1.

In some embodiments, the gripping device 40 may be further used to mix the blood sample to be tested to ensure uniformity of blood cell distribution in the blood sample and to increase accuracy of testing the blood sample.

It is to be understood that reference to "homogenization" may refer to, among other things, mixing the blood sample within the sample container 201 evenly by vibration and/or oscillation and/or rotation and/or agitation at a certain frequency.

Specifically, before sampling and detecting a blood sample to be detected, the sample container 201 located on the sample rack 2 may be sequentially grabbed by the grabbing device 40, and by driving the sample container 201 to vibrate/swing/move back and forth/rotate, etc., the mixing process of the blood sample to be detected in the sample container 201 is implemented, and then the blood sample is put back on the sample rack 2, and is waiting to be transmitted to the sampling position 12 for sampling and detecting.

As also shown in fig. 1, in the second direction, the incubation cavity 21 is located at the rear side of the grasping location 11. The gripping means 40 are mounted on the side of the incubation cavity 21 facing away from the gripping location 11 and can be moved back and forth between the incubation cavity 21 and the gripping location 11.

It should be understood that the "rear side" is herein the side of the sample channel 10 that is closer to the inside of the housing, i.e. the side of the sample channel 10 that is directed upwards in the angle shown in fig. 1, i.e. the side of the sample channel 10 that is farther from the user during use of the sample analyzer 1 (if the user is located at the sample channel 10).

In other alternative embodiments, the gripping means 40 and the incubation cavity 21 may also be arranged on opposite sides of the gripping location 11, respectively.

As further shown in fig. 3, in some embodiments, the gripping device 40 further includes a second gripping location 402 along its path of travel (including the portion shown in phantom). When the gripping means 40 is in the second gripping position 402, the gripping means 40 corresponds to the incubation cavity 21. The gripping device 40 may then grip the sample container 201 from the incubation cavity 21 or place the sample container 201 within the incubation cavity 21.

It is to be understood that "when the gripping means 40 is in the second gripping position 402, the gripping means 40 corresponds to the incubation cavity 21", means that the gripping means 40 in the second gripping position 402 can perform a gripping operation on the sample container 201 in the second gripping position 402 to grip the first sample container 201.

Specifically, as with the first catch position 401, the second catch position 402 may not refer to a particular point location. At the second gripping position 402, the gripping device 40 may also perform gripping and placing operations on the sample container 201 by slightly moving horizontally (e.g., sampling the sample container 201 by horizontally moving the fork), or by the gripping device 40 itself (e.g., gripping device 40 with a jaw, which is tightened by opening the jaw), or the like. It is to be understood that in the present embodiment, when the gripping device 40 is at the same position as the incubation cavity 21 in both the first direction and the second direction, the bottom end position of the moving path of the gripping device 40 in the third direction is the second gripping position 402.

Further, with continued reference to fig. 3, the moving path of the gripping device 40 (including the portion shown by the dotted line in the figure) further includes a first transferring position 404 and a second transferring position 405. The first transfer station 404 is located above the first holding station 401 (holding station 11), the second transfer station 405 is located above the second holding station 402 (incubation cavity 21), and the first transfer station 404 and the second transfer station 405 are located at the same position in the third direction.

It should be understood that "the first transfer position 404 is located above the first pick-and-place position 401" means that the first transfer position 404 is located at the same position as the first pick-and-place position 401 in the first direction and the second direction, and the first transfer position 404 is located higher than the first pick-and-place position 401 in the third direction. The second transfer station 405 is identical to the second pick and place station 402.

In a specific process of transferring the sample container 201 by the gripping means 40, transfer of the sample container 201 from the gripping position 11 to the incubation cavity 21 is exemplified. It is first necessary to move the gripping device 40 to the first gripping position 401 so that the gripping device 40 grips the sample container 201 on the sample rack 2. Further, the gripping device 40 is moved in the third direction to the first transfer position 404, then from the first transfer position 404 to the second transfer position 405 in the second direction, and then from the second transfer position 405 to the second gripping position 402 in the third direction. At this time, the sample vessel 201 is located in the incubation cavity 21, and the gripping device 40 completes the handling operation.

The transfer of the sample vessel 201 from the incubation cavity 21 to the gripping position 11 by the gripping device 40 is achieved in the same way as the above-described steps, which are not described in detail here.

It is to be understood that the difference in height between the first pick-and-place position 401 and the first transfer position 404 in the third direction is not particularly limited herein. As long as the gripping device 40 grips the sample container 201 and the sample container 201 is accommodated in the incubation cavity 21, the movement of the gripping device 40 between the first transfer position 404 and the second transfer position 405 does not cause the bottom end of the sample container 201 gripped by the gripping device 40 to collide with the top end of the sample container 201 in the incubation cavity 21.

After the sample vessel 201 after incubation treatment is transported from the incubation cavity 21 back to the sample rack 2 on the grasping position 11, it can be transported through the sample introduction channel 10 to the sampling position 12 again for sampling. The control device 60 may determine the sample based on the subsampled detection result of the detection device 50, and if it is determined that the sample is not an agglutination sample, the detection result is the final test result.

It should be appreciated that, to ensure that the gripping device 40 is able to grip the sample container 201 back and forth between the first transfer position 404 and the second transfer position 405, the distance between the position of the first transfer position 404 in the third direction and the position of the topmost end of the sample rack 2 at the gripping position 11 in the third direction needs to be greater than or equal to the height of the sample container 201. Similarly, the distance between the position of the second transfer site 405 in the third direction and the position of the tip of the incubation device 20 at the incubation cavity 21 in the third direction is required to be equal to or greater than the height of the sample container 201.

As shown in fig. 3 and 4, since the first gripping position 401 is the lowest position of the gripping device 40 moving in the third direction at the gripping position 11, the second gripping position 402 is the lowest position of the gripping device 40 moving in the third direction at the incubation cavity 21. In some embodiments, the incubation device 20 is positioned within the rack such that the second capture position 402 is lower than the first capture position 401 in the third direction.

At this time, when the gripping device 40 is located at the first gripping position 401, the distance between the gripping device 40 and the bottom end of the incubation cavity 21 in the third direction is equal to or greater than the height of the sample container 201.

It should be understood that, because the incubation time of the agglutination sample is longer, in order to improve the detection efficiency of the sample analyzer 1, the sample analyzer 1 can synchronously perform detection and analysis on other blood samples to be detected in the incubation process, so as to ensure the continuity of the sampling and detection operation of the sample analyzer 1 and improve the detection efficiency. However, before the test, the blood sample to be tested in the sample container 201 needs to be uniformly mixed. Therefore, in the incubation process of the agglutination sample, the gripping device 40 needs to be moved to the first gripping position 401 to grip the sample container 201 to be detected, perform the homogenization process, and then, return the sample container 201 after the homogenization process to the sample rack 2.

During the mixing process of the blood sample to be tested, the gripping device 40 may be located at the first transfer site 404, at a position between the first gripping location 401 and the first transfer site 404, or at a position between the first transfer site 404 and the second transfer site 405. However, when the gripping device 40 is located at the first gripping position 401 to grip or place the sample container 201, since the first gripping position 401 is located closer to the second gripping position 402 in the third direction, and since at least part of the structure of the gripping device 40 in the present embodiment horizontally extends in the second direction, there may be a problem in that the gripping device 40 collides with the sample container 201 subjected to the incubation process in the incubation cavity 21.

In this embodiment, by lowering the position of the incubation cavity 21 in the third direction, the second grabbing and placing position 402 is lower than the first grabbing and placing position 401 in the third direction, so as to avoid the sample container 201 in the incubation cavity 21, so as to ensure that the grabbing device 40 can smoothly and continuously mix the blood sample to be detected in the incubation process of the agglutination sample 20 for a preset time, so as to ensure that the sample analyzer 1 can continuously detect the blood sample to be detected in the preset time. At the same time, the occupation of the internal space of the frame can be reduced, and the miniaturization of the sample analyzer 1 can be realized.

In other alternative embodiments, this may be achieved by increasing the distance separating the gripping location 11 from the incubation cavity 21 in the second direction. When the sample vessel 201 is present in the incubation cavity 21 and the gripping means 40 is in the first gripping position 401, the gripping means 40 does not collide with the sample vessel 201 in the incubation cavity 21.

It should be understood that, if the avoidance of the sample container 201 in the incubation cavity 21 is achieved by increasing the distance between the grabbing position 11 and the incubation cavity 21 in the second direction, the position of the incubation device 40 in the rack can be flexibly set (provided that the connection line between the incubation cavity 21 and the grabbing position 11 is still parallel to the Y axis), and the positional relationship between the first grabbing position 401 and the second grabbing position 402 in the third direction may not be limited. That is, in this embodiment, the first capturing position 401 and the second capturing position 402 may be located at the same position in the third direction, or the second capturing position 402 may be located higher than the first capturing position 401 in the third direction. So long as no collision with the sample vessel 201 located within the incubation cavity 21 occurs when the gripping means 40 is in the first gripping position 401.

In other alternative embodiments, the structure of the gripping device 40 may be adjusted, for example, the gripping device 40 extending horizontally along the second direction may be adjusted to extend vertically along the third direction (for example, the structure of a fork-type fork claw extending and arranged along the horizontal direction may be adjusted to a gripping manipulator structure arranged along the vertical direction, etc.), so as to solve the problem that the incubation cavity 21 needs to avoid.

In some embodiments, the incubation device 20 may also be movably disposed in the rack in a first direction, at which time, when the incubation of the agglutinated sample by the incubation device 20 is completed, the incubation device 20 may be moved to a position corresponding to the sampling position 12 by moving in the first direction such that the line connecting the incubation cavity 21 and the sampling position 12 is parallel to the Y-axis. The sampling needle may also be movably arranged in the second direction, and by moving the sampling needle in the second direction such that the sampling needle corresponds to the incubation cavity 21 at that time, the sampling operation of the agglutination sample after incubation can also be performed.

As further shown in fig. 3 and 4, in some embodiments, the sample analyzer 1 further includes at least one mixing device 30, and the mixing device 30 is disposed in the rack and is in control connection with the control device 60. On which at least one mixing chamber 31 is formed for receiving the sample container 201. The mixing device 30 can perform a mixing process on the blood sample in the sample container 201 positioned in the mixing chamber 31.

The control device 60 may be further configured to control the gripping device 40 to grip the sample container 201 into the blending chamber 31 and control the blending device 30 to perform a blending process thereon when the blood sample accommodated in the sample container 201 on the sample rack 2 is a trace amount of blood sample.

It should be understood that the mixing process of the mixing device 30 and the mixing process of the gripping device 40 have the same final purpose, and are all to ensure the uniformity of the distribution of blood cells in the blood sample to be sampled.

Specifically, the mixing device 30 may further include a driving component (not shown in the figure) for driving the sample container 201 in the mixing cavity 31 to vibrate or rotate, so as to implement a mixing process on the blood sample in the sample container 201 through driving with a certain frequency.

In this embodiment, the number of the mixing devices 30 is one, and only one mixing chamber 31 is included for mixing the trace amount of blood sample. The gripping device 40 is used for uniformly mixing the constant blood sample.

It is to be understood that during the process of drawing blood from a patient, the amount of blood sample drawn will vary from patient to patient or from site to site. The blood sample can be divided into a micro blood sample and a macro blood sample according to the volume of the blood sample. Wherein the blood volume of the micro-blood sample is much smaller than that of the macro-blood sample. The micro-blood sample has a small blood volume, so that the micro-blood sample can achieve the target effect by uniformly mixing the micro-blood sample with the grabbing device 40 before sampling and detecting the micro-blood sample, but the micro-blood sample cannot achieve the target effect due to the small blood volume.

The term "target effect" is understood to mean the effect that sampling can be performed and the uniformity of cells in a blood sample can ensure the accuracy of sampling detection.

It should be noted that the microablood sample may be an agglutination sample or a non-agglutination sample. The constant blood sample may be an agglutination sample or a non-agglutination sample.

It should be understood that, in the present embodiment, the mixing device 30 is not used as a limitation of the mixing device 30 to mix only the trace amount of blood. The gripping device 40 is not used as a restriction that the gripping device 40 can only be used to blend a constant blood sample. That is, in other alternative embodiments, the mixing device 30 may also perform a mixing process on a constant blood sample, and the gripping device 40 may also perform a mixing process on a trace blood sample.

In other alternative embodiments, the number of the mixing devices 30 may be set to be plural, or the number of the mixing chambers 31 may be set to be plural. When the mixing device 30 comprises a plurality of mixing chambers 31, the drive assembly may be caused to act on the plurality of mixing chambers 31 simultaneously or separately.

As shown in fig. 1 and 3, in the present embodiment, the mixing chamber 31 and the grasping position 11 and the incubation chamber 21 are positioned at the same position in the first direction, that is, the line connecting the three is parallel to the Y axis. The mixing chamber 31 is located on the side of the incubation chamber 21 remote from the gripping position 11 in the second direction.

Correspondingly, the gripping device 40 further comprises a third gripping position 403 and a third transferring position 406 on its movement path (including the part shown by the broken line in the figure). The third transfer position 406 is located at the same height position as the first transfer position 404 and the second transfer position 405 in the third direction, and the connecting lines of the three positions are parallel to the Y axis. The third transfer location 406 is identical to the third gripping location 403 in the first and second directions, i.e. the third transfer location 406 is located above the third gripping location 403 (mixing chamber 31). When the gripping means 40 is in the third gripping position 403, the gripping means 40 corresponds to the mixing chamber 31.

It should be understood that "when the gripping means 40 is in the third gripping position 403, the gripping means 40 corresponds to the mixing chamber 31" means that the gripping means 40 in the third gripping position 403 may perform a gripping operation on the sample container 201 at the third gripping position 403 to grip the first sample container 201.

Specifically, in the same manner as the first capturing position 401 and the second capturing position 402, the third capturing position 403 may not refer to a specific point, and will not be described herein. However, it should be understood that, in the present embodiment, when the gripping device 40 is located at the same position as the mixing chamber 31 in both the first direction and the second direction, the bottom end position of the moving path of the gripping device 40 in the third direction is the third gripping position 403.

In a specific operation, when the sample vessel 201 is accommodated in the incubation cavity 21, the incubation apparatus 20 performs an incubation process for a predetermined time for the sample vessel 201. In a preset time, when the control device 60 determines that the sample container 201 located at the grabbing position 11 on the sample rack 2 is the sample container 201 containing the trace blood sample, the grabbing device 40 may move to the first grabbing and placing position 401, grab the sample container 201 containing the trace blood sample located at the grabbing position 11, move up to the first transferring position 404 along the third direction, move from the first transferring position 404 to the third transferring position 406 along the second direction through the second transferring position 405, move down to the third grabbing and placing position 403 along the third direction from the third transferring position 406, and place the sample container 201 containing the trace blood sample in the mixing cavity 31. Further, the mixing device 30 performs a mixing process on the trace blood sample.

Further, the gripping device 40 may transfer the sample container 201 after the mixing process back to the sample rack 2 according to the reverse steps of the previous steps, which will not be described herein.

It should be understood that, to ensure that the gripping device 40 can drive the sample container 201 to transfer between the three transfer positions, the distance between the position of the third transfer position 406 in the third direction and the position of the top end of the mixing device 30 at the mixing chamber 31 in the third direction is also greater than or equal to the height of the sample container 201.

It will be appreciated that since the mixing chamber 31 is located on the side of the incubation chamber 21 remote from the gripping position 11 in the second direction, and since the third gripping position 403 is the lowest position of the gripping means 40 moving in the third direction at the position of the mixing chamber 31, and since the second gripping position 402 is the lowest position of the gripping means 40 moving in the third direction at the position of the incubation chamber 21. The mixing device 30 is disposed such that the height of the third grabbing and placing position 403 in the third direction is equal to or lower than the height of the second grabbing and placing position 402 in the third direction. At this time, when the gripping device 40 is placed or grips the sample container 201 toward the incubation cavity 21 at the second grip position 402, it does not collide with the mixing chamber 31 located at one side of the incubation cavity 21 to avoid the problem of collision of both.

In other alternative embodiments, avoidance of the mixing device 30 may also be achieved by controlling the setting positions of the mixing device 30 and the incubation device 20 such that the distance between the mixing chamber 31 and the incubation chamber 21 in the second direction is enlarged. When the grabbing device 40 is located at the second grabbing position 402, the grabbing device 40 will not collide with the incubation device 20.

It should be understood that, if the avoidance of the mixing device 30 is achieved by expanding the interval between the incubation cavity 21 and the mixing cavity 31 in the second direction, the position of the mixing device 30 in the rack may be flexibly set (provided that the connection line between the mixing cavity 31 and the grabbing position 11 is still parallel to the Y axis), and the setting position of the third grabbing position 403 corresponding to the mixing cavity 31 may not be specifically limited, and may be higher than the first grabbing position 401, or may be located between the first grabbing position 401 and the second grabbing position 402 in the third direction, and so on.

In other alternative embodiments, as shown in FIG. 4, the mixing device 30 may be positioned within the housing such that the mixing chamber 31 is positioned between the incubation chamber 21 and the grasping station 11 in the second orientation.

At this time, since the first grabbing position 401 is the lowest position of the grabbing device 40 moving along the third direction at the position where the grabbing position 11 is located, and the third grabbing position 403 is the lowest position of the grabbing device 40 moving along the third direction at the position where the mixing cavity 31 is located, the setting position of the mixing device 30 needs to satisfy that the height of the third grabbing position 403 in the third direction is equal to or lower than the height of the first grabbing position 401 in the third direction. It is avoided that the gripping device 40 collides with the mixing device 30 when the gripping device 40 grips the sample container 201 on the sample rack 2 from the gripping position 11 at the first gripping position 401 or the sample container 201 is put back on the sample rack 2.

Similarly, since the third holding position 403 is the lowest position at which the grasping apparatus 40 moves in the third direction at the position of the mixing chamber 31, and since the second holding position 402 is the lowest position at which the grasping apparatus 40 moves in the third direction at the position of the incubation chamber 21. The position of the incubation device 20 is set so that the height of the second holding position 402 in the third direction is lower than the height of the third holding position 403 in the third direction.

At this time, the difference between the heights of the second holding position 402 and the third holding position 403 in the third direction needs to be satisfied, and when the gripping device 40 is located at the third holding position 403 and the sample container 201 is contained in the incubation cavity 21 at this time, the distance between the gripping device 40 located at the third holding position 403 and the bottom end of the incubation cavity 21 in the third direction is greater than or equal to the height of the sample container 201.

By setting the height difference between the incubation cavity 21 and the mixing cavity 31 in the third direction, when the sample container 201 is accommodated in the incubation cavity 21 and the blood sample in the sample container 201 at the grasping position 11 on the sample rack 2 is a trace blood sample, the grasping device 40 can avoid collision to the sample container 201 positioned in the incubation cavity 21 when the grasping device 40 is positioned at the third grasping position 403 during the process of conveying the sample container 201 accommodating the trace blood sample to the mixing cavity 31 for the mixing process.

In other alternative embodiments, the positional relationship among the incubation cavity 21, the mixing cavity 31 and the gripping position 11 may also be such that the extending direction of the connecting line of the three is not parallel to the Y axis, and by adding a moving path of the gripping device 40 in the first direction, the gripping device 40 may realize the handling of the sample container 201 among the incubation cavity 21, the mixing cavity 31 and the gripping position 11.

In some embodiments, the homogenization device 30 may also perform deagglomeration operations on the agglutinated sample by a homogenization process.

It is to be understood that the deagglomeration treatment is used to perform a deagglomeration operation on the agglutinated blood cells of the agglutinated sample, so that the sample analyzer 1 can detect the blood sample after the deagglomeration treatment to improve the accuracy of the detection. The incubation process of the incubation apparatus 20, the homogenization process of the gripping apparatus 40 and/or the homogenization apparatus 30, and the dilution process of the dilution unit may be regarded as deagglomeration processes of the agglutinated sample. The sample analyzer 1 can flexibly select a deagglomeration treatment mode or select two or more treatment modes to be used in combination according to different conditions of agglutination samples.

For example, when the agglutination sample is a erythrocyte agglutination sample, the deagglomeration treatment is at least one of an incubation treatment, a homogenization treatment, and a dilution treatment, so that the agglutination-occurring erythrocytes are dispersed and then measured. For another example, when the agglutination sample is a PLT agglutination sample, the deagglomeration treatment is a test channel conversion, the test channel is converted into a PLT-F channel for testing, forward scattered light and lateral fluorescence of the PLT are obtained by semiconductor laser flow cytometry, a two-dimensional scatter diagram is formed, and further PLT is counted more accurately.

Thus, in some embodiments, the incubation device 20 and the mixing device 30 may also simultaneously perform an incubation process and a deagglomeration process on the blood sample within the same sample container 201. That is, the incubation cavity 21 and the mixing cavity 31 may be the same cavity in some embodiments. At this time, both the heating means of the incubation apparatus 20 and the driving means of the mixing apparatus 30 act on the chamber, so that the blood sample in the sample container 201 located in the chamber can be simultaneously subjected to the incubation process and the mixing process. In this case, when the blood sample in the chamber is an aggregated sample, the deagglomeration efficiency of the aggregated sample can be increased, the working time can be shortened, and the sampling and detecting efficiency of the sample analyzer 1 can be further improved.

In some embodiments, the sample analyzer 1 further comprises a manual sample introduction device (not shown in the figure) provided with a sample introduction chamber 70 (shown in fig. 1) for placing a sample container 201 containing a blood sample which is required to obtain a detection result. The sample injection cavity is spaced from the sample site 12 in a second direction. The sampling needle of the detection device 50 may be movably arranged in the second direction.

Specifically, the sample injection chamber 70 is disposed at a side of the sample injection channel 10 away from the incubation device 20 and the mixing device 30, so as to facilitate the operation of the user. When a blood sample is urgently needed to obtain a detection result, an operator can manually mix the urgent blood sample, and place the sample container 201 after the manual mixing is completed in a sample injection cavity of the manual sample injection device. At this time, the control device 60 may control the sampling needle to move in the second direction to correspond to the sampling cavity, and control the sampling needle to move downward in the third direction to collect the blood sample in the sample container 201 located in the sampling cavity.

In some embodiments, at least one incubation device 20 may also be provided on the manual feeding device to increase the number of incubation cavities 21 of the sample analyzer 1. At this time, the incubation cavity 21 of the manual sample feeding device needs to be spaced apart from the sample feeding cavity and the sample position 12 in the second direction. Or the incubation cavity 21 can be used as a sample injection cavity of a manual sample injection device, so that the incubation cavity can be used for injecting the emergency sample and also can be used for carrying out incubation treatment on the agglutination sample.

Fig. 5 to 8 show a sample analyzer 1 in a second embodiment of the present application, which is different from the sample analyzer 1 in the first embodiment in that in the present embodiment, an incubation cavity 21 of the sample analyzer 1 is movably provided in a third direction. So as to drive the movement of the sample container 201 in the incubation cavity 21 by the movement of the incubation cavity 21, thereby realizing the avoiding effect.

Specifically, as shown in fig. 5 and 6, the incubation cavity 21 may include a avoidance 211 and a receiving position 212 along the moving path in the third direction. The accommodation position 212 is higher than the avoidance position 211.

When the gripping device 40 is in the second gripping position 402, as shown in fig. 5, the incubation cavity 21 is in the receiving position 212, in which case the gripping device 40 may perform a gripping operation on the sample container 201 positioned in the incubation cavity 21.

As shown in fig. 6, when the gripping device 40 is in the first gripping position 401 and the sample vessel 201 is contained in the incubation cavity 21, the incubation cavity 21 is in the avoidance position 211. At this time, the distance between the gripping device 40 and the bottom end of the incubation cavity 21 in the third direction is greater than or equal to the height of the sample container 201, so that the gripping device 40 can avoid the sample container 201 in the incubation cavity 21.

It should be understood that when the sample container 201 is not contained in the incubation cavity 21, the incubation cavity 21 may be located in the avoidance position 211 or the storage position 212 without limitation in the case that the gripping device 40 is not located in the second gripping position 402. As long as the position thereof is set, the gripping device 40 does not collide with it during normal gripping operation.

That is, since the first grasping position 401 is the lowest position at which the grasping apparatus 40 moves in the third direction at the grasping position 11 and the second grasping position 402 is the lowest position at which the grasping apparatus 40 moves in the third direction at the incubation cavity 21, the setting position of the incubation apparatus 20 needs to be satisfied, and the position of the second grasping position 402 of the grasping apparatus 40 in the third direction is equal to or lower than the first grasping position 401. At this time, when the gripping device 40 is in the first gripping position 401 and the sample container 201 is not accommodated in the incubation cavity 21, no collision with the incubation device 20 occurs during the normal gripping operation of the gripping device 40 regardless of whether the incubation cavity 21 is in the avoidance position 211 or the accommodation position 212.

It is to be understood that the incubation cavity 21 may be movably arranged in the third direction, the entire incubation device 20 may be movably arranged in the third direction, the wall of the incubation device 20 defining the incubation cavity 21 may be movably arranged in the third direction, the incubation device 20 may be provided with an elevating member or a spring or the like operable elastic member within the incubation cavity 21, such that the sample container 201 located within the incubation cavity 21 is movably arranged in the third direction, etc., without being specifically limited thereto.

With continued reference to fig. 5 and 6, in some embodiments, when the sample analyzer 1 may further include a mixing device 30, the mixing chamber 31 of the mixing device 30 is located on a side of the incubation chamber 21 away from the grasping location 11 in the second direction.

At this time, since the lowermost end of the movement of the grasping apparatus 40 in the third direction at the mixing chamber 31 is the third grasping and placing position 403, and since the lowermost end of the movement of the grasping apparatus 40 in the third direction at the incubation chamber 21 is the second grasping and placing position. The setting position of the mixing device 30 needs to be satisfied, and the height position of the third grabbing and placing position 403 of the grabbing device 40 in the third direction is equal to or lower than the height position of the second grabbing and placing position 402 in the third direction.

By defining the positional relationship of the third grip position 403 and the second grip position 402 in the third direction, it is ensured that the gripping means 40 does not collide with the mixing device 30 located on one side of the incubation cavity 21 when the gripping means 40 is located at the second grip position 402 and the sample container 201 is placed or gripped into the incubation cavity 21.

In other alternative embodiments, as shown in FIGS. 7 and 8, the mixing chamber 31 of the mixing device 30 may also be located between the incubation chamber 21 and the grasping station 11 in the second direction.

At this time, since the grasping apparatus 40 is the first grasping position 401 at the bottommost end that moves in the third direction with the grasping position 11, and since the grasping apparatus 40 is the third grasping position 403 at the bottommost end that moves in the third direction with the mixing chamber 31. The setting position of the mixing device 30 needs to be satisfied, and the height position of the third grabbing position 403 of the grabbing device 40 in the third direction is equal to or lower than the height position of the first grabbing position 401 in the third direction.

By defining the positional relationship of the third grip position 403 and the first grip position 401 in the third direction, it is ensured that the gripping device 40 does not collide with the blending device 30 when the sample container 201 is placed or gripped into the sample rack 2 at the first grip position 401.

Similarly, the bottommost end of the movement of the gripping device 40 in the third direction at the incubation cavity 21 is the second gripping position 402, and the bottommost end of the movement of the gripping device 40 in the third direction at the mixing cavity 31 is the third gripping position 403. The position of the incubation device 20 is set so that the height of the second holding position 402 of the gripping device 40 in the third direction is equal to or lower than the height of the third holding position 403 in the third direction.

At this time, when the gripping device 40 is in the third gripping position 403 and the sample container 201 is not accommodated in the incubation cavity 21, no collision is generated between the gripping device 40 and the incubation device 20 during normal gripping operation of the mixing chamber 31, regardless of whether the incubation cavity 21 is in the avoidance position 211 or the accommodation position 212. As shown in fig. 8, when the gripping device 40 is in the third gripping position 403 and the incubation cavity 21 accommodates the sample container 201, the incubation cavity 21 is located at the avoidance position 211, and the distance between the gripping device 40 and the bottom end of the incubation cavity 21 located at the avoidance position 211 in the third direction is greater than or equal to the height of the sample container 201. So that the gripping device 40 can avoid the sample container 201 in the incubation cavity 21 during normal gripping operation at the mixing cavity 31.

It should be understood that, in this embodiment, when the sample container 201 is not contained in the incubation cavity 21 and the gripping device 40 is not located in the third gripping position 403, the incubation cavity 21 may be located in the avoidance position 211 or the storage position 212, which is not limited herein.

Fig. 9 and 10 show a sample analyzer 1 according to a third embodiment of the present application, which is mainly different from the sample analyzer 1 according to the first embodiment in that:

In the present embodiment, the gripping device 40 includes a gripping portion 41, a connecting portion 42, and a guide rail (not shown in the figure). Wherein the guide rail extends along a third direction and a second direction. The connecting portion 42 is movably disposed on the guide rail, and is movably disposed along the guide rail in the second direction and the third direction. The gripping portion 41 is connected to the connecting portion 42, and is movably disposed along a second direction and a third direction under the driving of the connecting portion 42, and the gripping portion 41 is configured to grip and convey the sample container 201 by moving in the second direction and the third direction. An escape space 43 is defined between the grasping portion 41 and the connecting portion 42.

When the gripping device 40 is located at the first gripping position 401, the avoiding space 43 corresponds to the incubation cavity 21, and the distance between the top end of the avoiding space 43 and the bottom end of the incubation cavity 21 in the third direction is greater than or equal to the height of the sample container 201.

It should be understood that "when the grasping apparatus 40 is located at the first grasping position 401, the avoiding space 43 corresponds to the incubation cavity 21", and in this embodiment, it is understood that the position of the incubation cavity 21 in the X-axis and the Y-axis is located within a range defined by the avoiding space 43 in the X-axis and the Y-axis.

By arranging the grabbing device 40 to form the avoidance space 43, the sample container 201 can be contained in the incubation cavity 21, and when the grabbing device 40 is located at the first grabbing position 401, the height of the incubation cavity 21 (or the distance between the incubation cavity 21 and the grabbing position 11) is not required to be reduced, so that the grabbing device 40 and the sample container 201 in the incubation cavity 21 are prevented from blocking collision, occupation of space in a rack is further reduced, miniaturization of equipment is achieved, and meanwhile incubation treatment of an agglutination sample and mixing detection operation of the sample to be detected are synchronously carried out.

Further, in the present embodiment, the connection portion 42 includes a vertical portion 421 and a horizontal portion 422. Wherein the vertical portion 421 is vertically extended in the third direction, the horizontal portion 422 is horizontally extended in the second direction, and an upper end of the vertical portion 421 is connected to a front side end of the horizontal portion 422. The horizontal portion 422 is also movably disposed on the rail. The grasping portion 41 is provided extending horizontally in the second direction in the present embodiment, and its rear side end is connected to the lower end portion of the vertical portion 421 and extends to a side away from the vertical portion 421 in the second direction.

The connecting portion 42 is configured such that a projection thereof on a plane defined by the second direction and the third direction is substantially inclined in an L shape, and a projection thereof on a plane defined by the second direction and the third direction is substantially inverted in a zigzag shape. The grasping device 40 is disposed such that the horizontal portion 422 of the connecting portion 42 is positioned higher than the grasping portion 41 in the third direction, and the vertical portion 421 of the connecting portion 42 defines the escape space 43 as compared with the horizontal portion 422 of the grasping portion 41.

It should be understood that the "front end" herein refers to the side end of the horizontal portion 422 that is close to the sample introduction channel 10 in the second direction, that is, the left side end to which the Y axis is directed in the angle shown in fig. 9. The "rear side end" refers to a side end of the grip portion 41 away from the sample introduction path 10 in the second direction, that is, a right side end directed opposite to the Y axis in the angle shown in fig. 9.

In other alternative embodiments, the connecting portion 42 and the grasping portion 41 may be provided in other shapes such as arc-shaped, irregular structures, and the like. It is to be understood that the configuration of the gripping portion 41 and the connecting portion 42 is sufficient as long as at least a part of the structure of the connecting portion 42 is located at the rear side of the gripping portion 41 in the second direction and at least a part of the structure is higher than the gripping portion 41 in the third direction, so that the sample container 201 in the incubation cavity 21 can be avoided by the height difference (i.e., the avoiding space 43) between the gripping portion 41 and at least a part of the structure of the connecting portion 42 when the gripping device 40 is located at the first gripping position 401.

The connection portion 42 and the grasping portion 41 may be integrally formed, or may be connected by welding, connection by a connector, or the like, and are not particularly limited herein.

Further, in the present embodiment, the distance between the grasping position 11 and the incubation cavity 21 in the second direction is equal to or greater than the length of the grasping portion 41 in the second direction. And when the gripping device 40 is positioned at the first gripping position 401, the incubation cavity 21 corresponds to the horizontal portion 422 of the connection portion 42, and the distance from the bottom end of the horizontal portion 422 to the bottom end of the incubation cavity 21 in the third direction is greater than or equal to the height of the sample container 201.

In some embodiments, when the sample analyzer 1 may further comprise a mixing device 30, and the mixing chamber 31 of the mixing device 30 is located at a side of the incubation chamber 21 remote from the grasping position 11 in the second direction.

The present application also constructs a sample analyzer 1 in the fourth embodiment, which is mainly different from the first embodiment in that in the present embodiment:

The gripping device 40 comprises a gripping portion 41 which is arranged movably in the second direction as well as in the third direction and which can be arranged swingably back and forth in the first direction.

It should be understood that the gripping portion 41 in the present embodiment is a jaw structure extending in the third direction or the second direction, and the gripping of the sample container 201 is achieved by the gripping action of the jaws.

When the gripping portion 41 is arranged to extend vertically in the third direction, it may not be necessary to consider the problem of avoiding the sample container 201 in the incubation cavity 21 when the sample container 201 is accommodated in the incubation cavity 21 and when the gripping device 40 is located in the first gripping position 401. At this time, the distance in the second direction between the grasping place 11, the incubation cavity 21, and the mixing cavity 31 can be further reduced to further reduce the occupation of the internal space of the rack, achieving miniaturization of the apparatus.

In some embodiments, as is the case when the sample analyzer 1 is provided with the mixing device 30, the problem of avoidance of the sample vessel 201 within the incubation cavity 21 may be eliminated, whether the mixing cavity 31 is located between the incubation cavity 21 and the grasping site 11 in the second direction or on the side of the incubation cavity 21 remote from the grasping site 11.

In some embodiments, however, when the sample analyzer 1 is provided with the mixing device 30 and the mixing chamber 31 is located on the side of the incubation chamber 21 remote from the grasping position 11, it is necessary to control the moving distance of the grasping portion 41 in the third direction.

It should be understood that, in this embodiment, when the sample container 201 is accommodated in the incubation cavity 21 and the control device 60 determines that the sample container 201 at the grabbing position 11 is a micro blood sample container, and the micro blood sample is required to be grabbed to the mixing cavity 31 for mixing, the grabbing portion 41 grabs the sample container 201 accommodating the micro blood sample, and moves from the first transferring position 404 to the third transferring position 406, and when the sample container passes through the second transferring position 405, if the moving distance of the grabbing portion 41 in the third direction is not controlled, the bottom end of the sample container 201 accommodating the micro blood sample may collide with the top end of the sample container 201 in the incubation cavity 21.

At this time, by providing the grasping portion 41 so as to deflect in the first direction, the moving distance of the grasping portion 41 in the third direction can be shortened, the space occupation can be reduced, and the occurrence of collision between the bottom end of the sample container 201 containing a trace amount of blood sample and the top end of the sample container 201 in the incubation cavity 21 can be avoided.

Which can be achieved by control of the control means 60. The control device 60 may be configured to: the gripping device 40 is controlled to deflect and avoid when passing the second transfer position 405 when moving from the first transfer position 404 to the third transfer position 406 (or from the third transfer position 406 to the first transfer position 404).

Specifically, when the control device 60 determines that the grabbing portion 41 is about to pass through the second transfer position 405 during the process that the grabbing portion 41 grabs the sample container 201 containing the trace blood sample along the first transfer position 404 to move to the third transfer position 406, the grabbing portion 41 is controlled to deflect along the first direction so as to avoid collision between the two sample containers 201 in the incubation cavity 21. When the control device 60 determines that the gripping portion 41 has passed through the second transferring position 405, the gripping portion 41 is controlled to swing back along the first direction, so that the sample container 201 gripped by the gripping portion 41 returns to the vertically arranged state, so as to ensure that the sample container can be smoothly placed into the mixing chamber 31.

After the mixing device 30 finishes the mixing process of the trace blood sample, the gripping device 40 handles the movement of the sample container 201 containing the trace blood sample from the third transfer position 406 to the first transfer position 404, and no further description is given here.

It should be understood that "when the gripping portion 41 passes the second transferring position 405" may be understood as any position of the gripping portion 41 before reaching the second transferring position 405, as long as the sample container 201 gripped by the gripping portion 41 does not collide with other components when starting to deflect at the position. Similarly, the "when the gripper 41 has passed through the second transfer position 405" may be any position of the gripper 41 after passing through the second transfer position 405, as long as the start of the backswing at that position does not cause the sample container 201 gripped by the gripper 41 to collide with other components. The present invention is not particularly limited herein.

It will be appreciated that the control device 60 controls the gripping part 41 to deflect as the gripping part 41 passes the second transfer position 405, which may be done only when it is detected that the sample container 201 is placed in the incubation cavity 21 and the gripping part 41 grips the sample container 201. The sample vessel 201 may be deflected as long as it passes the second transfer position 405, irrespective of the placement of the sample vessel 201 in the incubation cavity 21 and/or irrespective of the gripping of the sample vessel 201 by the gripping part 41.

In other alternative embodiments, the gripping portion 41 may also be swingably provided in the second direction, or in any direction between the second direction and the first direction, or the like. It is to be understood that the swinging direction of the grasping portion 41 is sufficient to achieve both uniform mixing of a constant blood sample and avoidance of the sample container 201 in the incubation cavity 21.

The present application also constructs a sample analysis method which is suitable for the sample analyzer 1 of any one of the above embodiments. As shown in fig. 11, the sample analysis method includes the steps of:

In step S1, the control device 60 acquires information of the blood sample in the sample container 201 loaded on the sample rack 2 in the sample introduction path 10, and determines the type of the blood sample based on the information.

It should be understood that, in the present embodiment, for the first detected blood sample, the sample analyzer 1 will convey the sample rack 2 through the sample introduction channel 10, so that the blood sample on the sample rack 2 sequentially passes through the sampling sites 12, and the detection device 50 collects and detects the blood sample passing through the sampling sites 12 one by one. The control device 60 can determine whether or not the blood sample is an aggregated sample one by one based on detection information of the blood sample sampled one by one.

It should be understood that, depending on the inspection item, the inspection unit 50 may include a plurality of inspection components, and different inspection components perform different inspection processes, which is not limited herein. The expression form of the sample information is different according to the detection mode of the detection unit 50. The detection information can be blood cell parameter information or histogram information of a blood cell count test; in the case where the detection unit 50 performs sample detection by laser scattering and fluorescent staining methods, the detection information may also be a statistical scatter diagram or the like of various types of cells. And are not limited herein.

In step S2, when the blood sample is determined to be an agglutination sample, the sample feeding channel 10 is controlled to feed the sample rack 2, so that the sample container 201 containing the agglutination sample on the sample rack 2 is located at the grabbing position 11.

Step S3, controlling the gripping device 40 to transfer the sample container 201 containing the agglutination sample from the gripping position 11 to the incubation cavity 21, and controlling the incubation device 20 to perform incubation treatment on the agglutination sample.

It should be understood that, in step S3, the "agglutination sample" herein may be a trace blood sample or a constant blood sample.

In some embodiments, the sample analysis method further comprises:

In step S4, the control device 60 controls the gripping device 40 to transfer the sample container 201 containing the coagulated sample after the incubation treatment from the incubation cavity 21 back to the sample rack 2, and controls the sample introduction path 10 to transfer the sample container 201 from the gripping position 11 to the sampling position, and controls the detection device 50 to perform secondary detection on the coagulated sample after the incubation treatment.

It should be understood that, in step S4, if the detection result is still determined to be an agglutination sample, steps S2 to S4 may be repeated until the control device 60 determines that the detection result is a non-agglutination sample, and the detection result may be the final result of the blood sample.

In some embodiments, prior to step S1, the sample analysis method may further include the steps of:

In step S01, the sample feeding channel 10 is controlled to transport the sample rack 2, so that the sample container 201 to be detected on the sample rack 2 is located at the grabbing position 11, and the grabbing device 40 is controlled to mix the blood sample on the sample container 201 uniformly.

In step S02, the sample feeding channel 10 is controlled to transport the sample rack 2, so that the sample container 201 after the mixing process on the sample rack 2 is transferred to the sampling position 11, and the detecting device 50 is controlled to sample and detect the blood sample in the sample container 201 after the mixing process is finished.

It should be understood that the control device may repeat the steps S01 and S02 before determining that the agglutination sample is present on the sample holder 2 according to the detection result. After step S1, the detection result obtained by the sampling detection in step S02 may be the final result of the blood sample, which is not judged by the control device 60 as the blood sample having the aggregated sample.

In some embodiments, as shown in fig. 12, this step S3 includes:

step S31, the gripping device 40 is controlled to move to the first gripping position 401, and grips the sample container 201 containing the agglutination sample.

Step S32, controlling the gripping device 40 to transfer the sample container 201 from the first gripping position 401 to the second gripping position 402, and controlling the gripping device 40 to place the sample container 201 containing the agglutinating sample in the incubation cavity 21.

Step S33, controlling the incubation device 20 to perform an incubation process on the agglutination sample in the sample container 201 located in the incubation cavity 21.

In some embodiments, when the sample analyzer 1 is provided with the mixing device 30, before step S1, the step S01 further includes:

the sample introduction path 10 is controlled to convey the sample rack 2 such that the sample containers 201 on the sample rack 2 sequentially pass through the grasping positions 11, and the grasping device 40 or the mixing device 30 is controlled to perform a mixing process on the blood samples on the sample containers 201 located on the grasping positions 11.

Specifically, the step S01 includes:

In step S011, when it is determined that the blood sample in the sample container 201 at the grasping position 11 is a trace blood sample, the grasping device 40 is controlled to transfer the sample container 201 containing the trace blood sample to the mixing chamber 31, the mixing device 30 is controlled to mix the trace blood sample in the sample container 201, and then the grasping device 40 is controlled to transfer the sample container 201 after the mixing process is completed back to the sample rack 2.

In step S012, when it is determined that the blood sample in the sample container 201 located at the grasping position 11 is a constant blood sample, the grasping device 40 is controlled to grasp the sample container 201 containing a trace amount of blood sample, and the sample container 201 after completion of the homogenization treatment is returned to the sample holder 2.

The "micro blood sample" herein represents only a micro blood sample that is detected for the first time (i.e., not labeled as an agglutination sample). The "microablood sample" may be an agglutination sample or a non-agglutination sample, and it is necessary to sample and detect the sample and then determine whether or not the sample is an agglutination sample that requires secondary detection.

Similarly, a "constant blood sample" herein represents only a constant blood sample that was first detected (i.e., not labeled as an agglutination sample). The "constant blood sample" may be an agglutination sample or a non-agglutination sample, and it is necessary to sample and detect the sample and then determine whether or not the sample is an agglutination sample that requires secondary detection.

It should be understood that whether the sample contained in the sample container 201 is a micro-blood sample or a macro-blood sample belongs to the encoded raw information content on the sample container 201.

As shown in fig. 13, further, when the sample analyzer 1 is provided with the mixing device 30, the step S33 may further include: the incubation device 20 is controlled to perform incubation treatment for a predetermined time for the coagulated sample in the sample container 201 located in the incubation cavity 21.

At this time, after step S33, the step S3 may further include:

In step S34, the gripping device 40 or the mixing device 30 is controlled to sequentially mix the sample containers 201 on the sample rack 2, which are determined to be non-agglutinated samples, for the preset time.

It should be understood that "non-agglutinating sample" herein represents only the blood sample that was first detected (i.e., not labeled as an agglutinating sample). The blood sample may be a constant blood sample or a non-constant blood sample.

Specifically, as shown in fig. 14, this step S34 includes:

In step S341, the sample feeding channel 10 is controlled to transport the sample rack 2 within the preset time, so that the sample container 201 with the non-agglutination sample accommodated on the sample rack 2 is transported to the grabbing position 11.

In step S3421, when it is determined that the non-agglutination sample at the grasping location 11 is a constant blood sample, the grasping device 40 is controlled to grasp the sample container 201 containing the constant blood sample and perform a mixing process on the constant blood sample.

In step S3422, when the non-agglutination sample at the grasping location 11 is determined to be a trace blood sample, the grasping device 40 is controlled to transfer the sample container 201 containing the trace blood sample to the mixing chamber 31, and the mixing device 30 is controlled to uniformly process the trace blood sample.

In some embodiments, after step S3422, step S34 further includes:

In step S343, the gripping device 40 is controlled to transfer the sample container 201 after the blending process back to the sample rack 2, the sample channel 10 is controlled to transfer the sample container 201 after the blending process to the sampling position 12, and the detecting device 50 is controlled to sample and detect the blood sample after the blending process.

It should be understood that, in the preset time, the step S34 (step S341 to step S343) may be repeated, so that the steps of mixing, sampling and detecting the blood samples on the sample rack 2 that have not been subjected to sampling and detecting are performed one by one in the preset time until the preset time is reached, so as to improve the detection efficiency of the sample analyzer 1.

In some embodiments, for the sample analyzer 1 in which the incubation cavity 21 can move back and forth between the avoidance position 211 and the storage position 212, as shown in fig. 15, the step S32 includes: the incubation means 20 is controlled such that the incubation cavity 21 is moved to the receiving position 212 and the gripping means 40 is controlled to transfer from the first gripping position 401 to the second gripping position 402, and the gripping means 40 is controlled to place the sample container 201 containing the agglutinating sample within the incubation cavity 21.

The step S3421 includes: when it is judged that the non-aggregated sample at the grasping position 11 is a constant blood sample, the incubation device 20 is controlled so that the incubation cavity 21 is moved to the avoidance position 211, and the grasping device 40 is controlled to move to the first grasping and placing position 401, the sample container 201 containing the constant blood sample is grasped, and the constant blood sample is subjected to a mixing process.

The step S3422 includes: when it is determined that the non-aggregated sample at the grasping position 11 is a trace blood sample, the incubation device 20 is controlled so that the incubation cavity 21 is moved to the avoidance position 211, the grasping device 40 is controlled to move to the first grasping and placing position 401, the sample container 201 containing the trace blood sample is grasped, the grasping device 40 is controlled to move from the first grasping and placing position 401 to the third grasping and placing position 403, the sample container 201 containing the trace blood sample is placed in the mixing cavity 31, and the mixing device 30 is controlled to mix the trace blood sample.

Specifically, for the sample analyzer 1 in which the mixing chamber 31 is located on the side of the incubation chamber 21 away from the grasping position 11 in the second direction, this step S3421 includes: when it is judged that the non-aggregated sample at the grasping position 11 is a constant blood sample, the incubation device 20 is controlled so that the incubation cavity 21 is moved to the avoidance position 211, and the grasping device 40 is controlled to move to the first grasping and placing position 401, the sample container 201 containing the constant blood sample is grasped, and the constant blood sample is subjected to a mixing process.

For the sample analyzer 1 in which the mixing chamber 31 is located between the incubation chamber 21 and the grasping position 11 in the second direction, "control the incubation apparatus 20 so that the incubation chamber 21 moves to the avoidance position 211" in this step S3422 may be performed before the grasping apparatus 40 moves to the first grasping position 401.

It should be understood that, for the sample analyzer 1 in such an embodiment, in repeating step S34, after the incubation cavity 21 moves to the avoidance position 211 for the first time, it may be at the avoidance position 211 until the preset time is reached. It may be located at the avoidance 211 only when it is necessary to avoid the sample container 201 in the incubation cavity 21, and may be moved to the storage position 212 at other times. The present invention is not particularly limited herein.

In some embodiments, the sample analyzer 1 may swing back and forth along the first direction for the grasping portion 41, and the mixing chamber 31 is located on the side of the incubation chamber 21 away from the grasping position 11 in the second direction, as shown in fig. 16, at this time, the step S3422 includes:

when it is determined that the non-aggregated sample at the grasping position 11 is a trace blood sample, the grasping apparatus 40 is controlled to move to the first grasping and placing position 401 to grasp the sample container 201 containing the trace blood sample.

Further, the gripping device 40 is controlled to move from the first gripping position 401 to the third gripping position 403, the sample container 201 containing the trace blood sample is placed in the mixing chamber 31, and the mixing device 30 is controlled to mix the trace blood sample.

Wherein, when the grabbing device 40 is located between the first transferring position 404 and the second transferring position 405, the grabbing device 40 is controlled such that the grabbing portion 41 deflects along the first direction, so that the sample container 201 containing a trace amount of blood sample can avoid the sample container 201 containing an aggregated sample located in the incubation cavity 21. When the gripping device 40 is between the second transfer position 405 and the third transfer position 406, the gripping device 40 is controlled such that the gripping portion 41 swings back in the first direction.

It should be understood that, in some embodiments, when the non-agglutinating sample at the grasping location 11 is determined to be a trace blood sample, the step S343 includes: the gripping device 40 is controlled to grip the sample container 201 after the completion of the homogenization treatment at the third grip position 403, and the gripping device 40 is controlled to move from the third grip position 403 to the first grip position 401, and the sample container 201 containing the trace amount of blood sample after the completion of the homogenization treatment is returned to the sample rack 2.

Further, the sample channel 10 is controlled to transfer the sample container 201 after the mixing process to the sampling position 12, and the detecting device 50 is controlled to sample and detect the blood sample after the mixing process.

When the gripping device 40 is located between the third transfer position 406 and the second transfer position 405, the gripping device 40 is controlled such that the gripping portion 41 deflects along the first direction, so that the sample container 201 containing a trace amount of blood sample can avoid the sample container 201 containing an aggregated sample located in the incubation cavity 21. When the gripping device 40 is between the second transfer position 405 and the first transfer position 404, the gripping device 40 is controlled such that the gripping portion 41 swings back in the first direction.

It is to be understood that the above examples represent only some embodiments of the invention, which are described in more detail and are not to be construed as limiting the scope of the invention; it should be noted that, for a person skilled in the art, the above technical features can be freely combined, and several variations and modifications can be made without departing from the scope of the invention; therefore, all changes and modifications that come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims

1. A sample analyzer, comprising:

The first direction, the second direction and the third direction are mutually perpendicular, the first direction is the length direction of the sample injection channel, the second direction is the width direction of the sample injection channel, and the third direction is the height direction of the sample injection channel; the incubation cavity is positioned at the rear side of the grabbing position;

Wherein the movement path of the gripping device further comprises a second gripping position, the gripping device corresponding to the Wen Yoqiang when the gripping device is in the second gripping position, to grip or place the sample container from the Wen Yoqiang to the incubation cavity; the second grabbing and placing position is lower than the first grabbing and placing position in the third direction; when the grabbing device is located at the first grabbing position, the distance between the grabbing device and the bottom end of the incubation cavity in the third direction is larger than or equal to the height of the sample container;

Or, the incubation cavity is movably arranged along the third direction, and the moving path of the incubation cavity comprises a avoidance position and a containing position, wherein the containing position is higher than the avoidance position; the moving path of the grabbing device further comprises a second grabbing and placing position; when the gripping device is in the second gripping position, the incubation cavity is in the receiving position, the gripping device corresponding to the Wen Yoqiang to grip or place the agglutination sample container from or to the Wen Yoqiang; when the gripping device is positioned at the first gripping position and the sample container is accommodated in the incubation cavity, the incubation cavity is positioned at the avoiding position; the position of the second grabbing and placing position in the third direction is equal to or lower than the first grabbing and placing position;

Or the grabbing device comprises a grabbing part, a connecting part and a guide rail; the guide rail extends along the third direction and the second direction; the connecting part is movably arranged on the guide rail, the grabbing part is connected with the connecting part, and an avoidance space is defined between the grabbing part and the connecting part; when the grabbing device is located at the first grabbing position, the avoiding space corresponds to Wen Yoqiang, and the distance from the top end of the avoiding space to the bottom end of Wen Yoqiang in the third direction is greater than or equal to the height of the sample container.

2. The sample analyzer of claim 1, wherein the gripping device comprises a gripping portion, a connecting portion, and a rail; the guide rail extends along the third direction and the second direction; the connecting part is movably arranged on the guide rail, the grabbing part is connected with the connecting part, and an avoidance space is defined between the grabbing part and the connecting part; when the grabbing device is located at the first grabbing position, the avoiding space corresponds to Wen Yoqiang, and the distance from the top end of the avoiding space to the bottom end of Wen Yoqiang in the third direction is greater than or equal to the height of the sample container;

The projection of the connecting part on a plane defined by the second direction and the third direction is in an inclined L shape, and the connecting part comprises a vertical part extending along the third direction and a horizontal part extending along the second direction; the upper end of the vertical part is connected with the front side end of the horizontal part, one end of the grabbing part is connected with the bottom end of the vertical part, and the grabbing part extends to one side far away from the vertical part along the second direction; the grasping portion, the vertical portion, and the horizontal portion together define the avoidance space.

3. The sample analyzer of claim 2, wherein a distance of the grasping location from the Wen Yoqiang in the second direction is greater than or equal to a length of the grasping portion in the second direction;

4. The sample analyzer of claim 1, further comprising at least one mixing device having at least one mixing chamber formed thereon for receiving the sample container, the mixing device being configured to mix the blood sample in the sample container within the mixing chamber;

5. The sample analyzer of claim 4, further comprising a third gripping location along the path of movement of the gripping device, the gripping device corresponding to the mixing chamber when the gripping device is in the third gripping location to grip or place the sample container from or to the mixing chamber; the third gripping position is located at a position equal to or lower than the first gripping position in the third direction.

6. The sample analyzer of claim 5, further comprising a second gripping position in the path of movement of the gripping device, the gripping device corresponding to the Wen Yoqiang when the gripping device is in the second gripping position to grip or place the sample container from the Wen Yoqiang to the incubation cavity;

7. The sample analyzer of claim 5, wherein the incubation cavity is movably disposed along the third direction and includes a clearance position and a receiving position on a movement path thereof, the receiving position being higher than the clearance position;

8. The sample analyzer of claim 4, wherein the homogenization chamber is located on a side of the incubation chamber remote from the grasping location in the second direction; the moving path of the grabbing device further comprises a first transferring position, a second transferring position and a third transferring position, and the positions of the first transferring position, the second transferring position and the third transferring position in the third direction are the same; the first transfer position is positioned above the first grabbing and placing position; the second translocation site is located above the incubation cavity; the third transfer position is positioned above the mixing cavity;

9. The sample analyzer of claim 4, wherein the mixing device is a micro-blood mixing device for mixing micro-blood samples;

10. The sample analyzer of claim 9, wherein the grasping device is further configured to mix a constant blood sample.

11. The sample analyzer of claim 1, further comprising a manual sample introduction device having a sample introduction cavity disposed thereon for placing a sample container, the sample introduction cavity being spaced apart from the sampling site in the second direction.

12. The sample analyzer of claim 11, wherein at least one incubation device is provided on the manual sample introduction device, and wherein the Wen Yoqiang of the incubation device is spaced apart from the sample introduction chamber and the sample site in the second direction.

13. The sample analyzer of claim 11, wherein at least one incubation device is provided on the manual sample introduction device, and wherein the Wen Yoqiang of the incubation device is the sample introduction chamber on the manual sample introduction device.

14. The sample analyzer of claim 1, further comprising a control device in control connection with the sample introduction channel, the incubation device, and the grasping device, respectively; the control device is configured to control the sample introduction channel to convey the sample rack and control the gripping device to grip the agglutination sample container for conveying to the incubation cavity in response to the sample container on the sample rack being the agglutination sample container.

15. A sample analysis method applied to the sample analyzer of any one of claims 1 to 14, further comprising a control device in control connection with the sample introduction channel, the incubation device and the gripping device, respectively, characterized in that the sample analysis method comprises the steps of:

16. The method of claim 15, further comprising a second gripping position on the path of movement of the gripping device, the gripping device corresponding to the Wen Yoqiang when the gripping device is in the second gripping position to grip or place the agglutinated sample container from the Wen Yoqiang to the incubation cavity;

The step S3 includes:

17. The sample analysis method of claim 16, wherein the sample analyzer further comprises at least one mixing device having at least one mixing chamber formed thereon for receiving the sample container; the mixing cavity is the same as the grabbing position and the Wen Yoqiang are positioned in the first direction; the control device is in control connection with the mixing device;

After the step S33, the step S3 further includes:

18. The sample analysis method according to claim 17, wherein the step S34 includes:

19. The method according to claim 18, wherein the incubation cavity is movably arranged in the third direction, and the movement path of the incubation cavity includes a avoidance position and a storage position, and the storage position is higher than the avoidance position; the moving path of the grabbing device further comprises a third grabbing position, and the third grabbing position corresponds to the mixing cavity;

20. The sample analysis method of claim 19, wherein the homogenization chamber is located on a side of the incubation chamber remote from the grasping location in the second direction;

21. The method according to claim 18, wherein the gripper further comprises a first transfer position, a second transfer position, a third transfer position, and a third gripping position along the movement path, and the first transfer position, the second transfer position, and the third transfer position are positioned at the same position in the third direction; the first transfer position is located above the first grabbing and placing position, the second transfer position is located above the second grabbing and placing position, and the third transfer position is located above the third grabbing and placing position; the third grabbing and placing position corresponds to the mixing cavity; the mixing cavity is positioned at one side of the incubation cavity away from the grabbing position in the second direction; the grabbing device comprises grabbing parts, and the grabbing parts are arranged in a swinging mode along the first direction;

The step S3422 further includes: